1665 results about "Coumarin" patented technology

Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.

This invention relates to compositions and electroluminescent (EL) devices that have enhanced performance as a result of a novel class of anthracene derivatives used as host materials for a full range of color dopands. When using coumarin derivatives as color dopands in the anthracene derivatives in an EL device, the device performs a desirable light emitting efficiency and durability. The performance of the EL device can be further improved by using benazole derivatives as the electron transporting layer. The organic EL device of the present invention is useful in preparing display devices.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or/and 22, or/and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle:

Where each or both R₁ and/or R₂ represents hydrogen; linear or branched C₁-C₁₈ alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups;

• • Each or both R₃ and/or R₄, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen; linear or branched C₁-C₁₈ alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; and
  • Each or both R₅ and/or R₆ represents a hydrogen atom, OH, C₁-C₄ acyl group, C₁-C₄ alkyl group, O—CO—R₇, O—COO—R₈ group, mesyl group or tosyl group, where each or both R₇ and/or R₈ represents hydrogen; linear or branched C₁-C₁₈ alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups.

Cosmetic compositions and methods, particularly for skin lightening, using 7-hydroxy-2-phenyl coumarin and derivatives of general formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle:

Where R₁ and/or R₂ may be positioned at the 1-, 2-, 3-, 5-, and/or 6-positions on the phenyl ring. Each or both R₁ and/or R₂ represents a hydrogen atom, OH, C₁–C₄ acyl group, or C₁–C₄ alkyl group; and

R represents a hydrogen atom, C₁–C₄ acyl group, or C₁–C₄ alkyl group.

Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with proteins in a non-covalent, non-specific manner at low pH, where the associated form displays a significantly higher fluorescence emission than the unassociated form. This makes the dyes useful as selective labels for proteins at the low pH and eliminates the need for the removal of extraneous components from the medium in which the proteins reside prior to detection.

The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

The invention provides a phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe for iron ion detection and synthesis and use methods thereof, relates to fluorescent molecular probes and synthesis and application thereof and aims to solve the problem that an existing Fe<3+> fluorescent probe is prone to being interfered by pH, concentration and other metal ions. The fluorescent molecular probe is 4-methyl-7-hydroxide radical-8-[2-(1- phenyl group-1H-phenanthrene and [9, 10-d] imidazole-2-)benzene ammonia methylene]-2H-pyran-2-ketone. The phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe is formed by conducting condensation on 1-N-phenyl group-2-(2-aminophenyl)-1H-phenanthrene and [9, 10-d] imidazole and 4-methyl-7-hydroxide radical-8- formyl group coumarin, and the yield is 75-85%. The fluorescent molecular probe is dissolved in mixed liquid of N, N- dimethylformamide and an HEPES buffering solution, existence of iron ions is judged through the absorbance value or fluorescence intensity change before and after adding of test samples, and the fluorescent molecular probe can be used for detection of Fe<3+> pollution in water.

Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating glaucomatous retinopathy or optic neuropathy. The structurally diverse agents that act on the Nrf2/ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.

An OLED device comprises a cathode, an anode, and has therebetween a light emitting layer comprising a phosphorescent emitter represented by Formula (I):

L_nM   (I)

wherein each L is a cyclometallated ligand with at least one containing a coumarin group, M is Ir or Pt, and n is 3 when M is Ir and 2 when M is Pt. The invention also comprised the compound of formula (I).

Disclosed are polymer-based dielectric compositions (e.g., formulations) and materials (e.g. films) and associated devices. The polymers generally include photocrosslinkable pendant groups; for example, the polymers can include one or more coumarin-containing pendant groups.

The invention discloses coumarin-oxacalix[3]arene fluorescent reagents as well as a preparation method and application thereof, and belongs to the fields of organic synthesis and analytical chemistry. The invention respectively synthesizes two coumarin-oxacalix[3]arene fluorescent reagents: chemical name a: 7,15,23-tertiary butyl-25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene; b: 7,15,23-triethoxycarbonyl -25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene. Meanwhile, the invention discloses a synthesis method and process conditions. According to the invention, the two coumarin-oxacalix[3]arene fluorescent reagents, in detecting ferric ions, have characteristics of high selectivity and high sensitivity; the fluorescent reagents are applicable to qualitative and quantitative analysis.

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.

The invention discloses a four-color fluorescence labeling reversible terminal and a use thereof in DNA (Deoxyribonucleic Acid) sequencing. The structural formula of the reversible terminal is as shown in a formula (I) in the specification, wherein R1 is triphosphate; R2 is H or OH; the basic group is U, C, A, G or derivatives thereof; the connecting unit is a bifunctional compound which is breakable under a mild condition; the fluorescence group is one selected from a combination of BODIPY, fluorescein, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, squarene dye and an energy transferring dye, and derivatives thereof. The reversible terminal provided by the invention can be used for DNA single-molecule sequencing; simultaneously, raw materials required by the synthesis of the reversible terminal provided by the invention are simple and easy to get and the synthesis process of the reversible terminal is completely involved with conventional chemical reactions, so that the four-color fluorescence labeling reversible terminal can be popularized and utilized to a large scale; biological evaluation results indicate that the reversible terminal is capable of completely meeting the biochemical reaction requirements of high-flux sequencing and has a good practical prospect.

The invention relates to a fluorescent probe for selectively detecting zinc ions in cells, a synthesizing method thereof and application thereof. The fluorescent probe has good selectivity for the zinc ions in vitro, and can be used for quick imaging of the zinc ions in the cells. The synthesizing method comprises the following steps: dissolving a coumarin-3-carbonyl compound with R1, R2, R3, R4 and R5 substituted groups into a drying organic solvent, slowing dropping 2-hydrazopyridine with R6 substituted group into the solution under refluxing and stirring, filtering the mixture after refluxing and stirring reaction, and removing the organic solvent to obtain the fluorescent probe (1) for selectively detecting the zinc ions in the cells. The fluorescent probe can be used for analysis detection and fluorescent imaging detection for the zinc ions in biological living cells and living tissues and detection for the zinc ions in pathological tissues in clinical medicine.

The present invention relates to an organic electroluminescent device comprising an anthracene derivative represented by Formula (1) shown below as a host and at least one selected from a perylene derivative, a borane derivative, a coumarin derivative, a pyran derivative, an iridium complex and a platinum complex as a dopant. The organic electroluminescent device of the present invention has a high efficiency, a long life, a low driving voltage and a high durability in storing and driving.

wherein R¹ to R⁴ and R¹² are independently hydrogen or alkyl having 1 to 12 carbon atoms; R⁵ to R¹¹ are independently hydrogen, alkyl having 1 to 12 carbon atoms, cycloalkyl having 3 to 12 carbon atoms or aryl having 6 to 12 carbon atoms; and Ar is non-condensed aryl represented by Formula (3); and m is an integer of 1 to 3;

wherein n is an integer of 0 to 5; R¹³ to R²¹ are independently hydrogen, alkyl having 1 to 12 carbon atoms or aryl having 6 to 12 carbon atoms.

The invention relates to the technical field of novel material organic chemicals, relates to a coumarin-carbazole type oxime ester compound as well as a preparation method and application thereof, and in particular relates to a novel compound of a structure of formula (I) or (II) as shown in the specification, a chemical preparation process technique of the novel compound, application of the novel compound as a radiation curing light-sensitive initiator, a radiation curing formula product of the novel compound, and particularly application of the novel compound in multiple places such as UV-Vis-LED excited light cured coatings or ink.

This invention provides encapsulated type fluorescent retroreflective sheeting which is excellent in appearance and weatherability, and which comprises a surface-protective layer disposed on the side on which light is to strike, a binder layer connected to the surface-protective layer through network bonding parts, an air layer which is sealed-up by the network bonding parts between the surface-protective layer and the binder layer, and a retroreflective element layer disposed between the surface-protective layer and the air layer, or between the binder layer and the air layer, wherein at least one layer located on the light-incident side of sealed-up air layer contains at least one fluorescent dye selected from the group consisting of benzimidazole coumarin type-fluorescent dyes of formula (1) as follows: and benzopyran type-fluorescent dyes of formula (2) as follows:

The invention discloses a medicine for treating pruritus caused by dermatitis, eczema and insect bite, and applications thereof. The medicine is a preparation prepared by the following components according to weight percentage: 0.1 percent to 90 percent of glycyrrhizic acid or physically acceptable salt of glycyrrhizic acid or glycyrrhetic acid or physically acceptable salt of glycyrrhetic acid, 0 percent to 90 percent of total matrines or physically acceptable salt of total matrines or oxymatrine or physically acceptable salt of oxymatrine or matrine or physically acceptable salt of matrine, 0 percent to 90 percent of hibiscus syriacus acid or physically acceptable salt of hibiscus syriacus acid or pseudolaric acid B or physically acceptable salt of pseudolaric acid B or osthole or total coumarins of fructus cnidii, and 1 percent to 5 percent of menthol or borneol. The medicine has the effect of anti-inflammatory, bacteriostasis and relieving itching, has unique therapeutic effect on pruritus caused by dermatitis, eczema and insect bite. The raw materials used by the medicine are nontoxic and cheap with low cost.

The present invention relates to an environmentally friendly shell powder functional coating, a preparation method therefor and uses thereof. The coating comprises: bisphenol A-epon, modified shell powder, vegetable extract, propyl silicone emulsion, a nano additive, a modified organic micro powder agent, a surfactant, dioctylphthalate, 3, 3'-(4-trifluoromethyl methyl)-bi-4-hydroxy coumarin, 2,2,4-amino trimethyl-1,3-isoprene glycol mono iso-butyl methacrylate, butyl acetate, ethanol, trimethylol propane triacrylate, N-ammonia amino ethyl piperazine, polydimethylsiloxane and deionized water. In the present invention, by modification of a variety of components and materials, selection and collocation of specific components and a specific preparation method, the variety of components exert a synergistic effect, so as to make the prepared coating have significant antimicrobial, environmental-cleaning and wear-resisting properties. The coating has a huge application potential and extensive value in industrial production.

This invention relates to novel coumarin derivative, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.

The invention provides coumarin derivatives as well as a preparation method and application thereof. The coumarin derivatives have the molecular formula: Cl3H6N2O4. The preparation method comprises the steps: firstly, preparing 4-chloromethyl-7-hydroxycoumarin, 4-hydroxymethyl-7-hydroxycoumarin and 7-hydroxycoumarin-4-formaldehyde; and then, adding the 7-hydroxycoumarin-4-formaldehyde into water, next, adding malononitrile and 1-methylimidazole, stirring at the room temperature, and filtering to obtain 2, 2-dicyano-3-(7-hydroxyl-4-coumarinyl)oxacyclopropane. The 2, 2-dicyano-3-(7-hydroxyl-4-coumarinyl)oxacyclopropane prepared by the preparation method can be used as a fluorescent probe for selectively detecting cysteine in an organism and can also be used for fluorescently marking cysteine in a cell so as to provide help for the diagnosis of related diseases in clinical medicals.

The invention discloses a method for synthesizing coumarin and derivatives thereof under catalysis of choline ionic liquids. According to the technical scheme, the method is characterized in that the coumarin and the derivatives thereof are prepared from a phenolic compound and beta-ketonic acid or keto ester under the catalytic action of choline ionic liquids and the choline ionic liquids include an ionic liquid of melted binary acid and choline chloride, a functionalized acidic choline ionic liquid and a protonized choline ionic liquid. According to the method disclosed by the invention, the synthesized choline ionic liquid is used for Pechmann condensation reaction; the negative and positive ions of the ionic liquids are adjusted according to the catalytic effect based on different acid-base properties of the ionic liquids, so that better catalytic effect can be achieved; the choline ionic liquids take the place of dangerous concentrated sulfuric acid when the choline ionic liquids are used for catalyzing the Pechmann reaction; the reaction conditions are simple, the product is easy to separate and no by-product is generated; more importantly, the catalyst can be reused.