458 results about "Antimicrobial drug" patented technology

The invention discloses a full D-type antibacterial peptide with high enzymolysis stability and broad-spectrum antibacterial activity and application thereof. The antibacterial peptide is obtained by sequentially and repeatedly arranging D-type tryptophan, D-type arginine and D-type lysine for four times and carrying out C-terminal amidation; the amino acid sequence of the gene is (D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-NH2, and is marked as DWRK-12. The antibacterial peptide shows broad-spectrum antibacterial activity and excellent stability, can effectively resist clinically separated multidrug resistant strains, and keeps high cell selectivity at the same time. Due to the characteristics, the antibacterial peptide has important application value in the aspect of developing novel antibacterial drugs, especially in the field of treatment of infection of multiple drug-resistant bacteria.

The invention relates to a preparation method of antibacterial gamma-polyglutamic acid superabsorbent hydrogel. The preparation method comprises the following steps: (1) preparing a gamma-polyglutamic acid solution; (2) dissolving an antibacterial agent in the gamma-polyglutamic acid solution, and fully stirring and uniformly mixing to obtain a mixed solution 1; adjusting the pH value of the mixed solution 1, heating the mixed solution 1 to 60 DEG C, and continuously reacting for 1-2 hours to obtain a mixed solution 2; cooling the mixed solution 2 to room temperature, adding a cross-linking agent, and uniformly mixing to obtain a mixed solution 3; standing the mixed solution 3 at room temperature for 1-3 hours and then carrying out gradient heating reaction to obtain an antibacterial gelatinous product; and (3) dehydrating the antibacterial gelatinous product, and carrying out vacuum negative pressure drying to obtain a dried hydrogel product, namely the antibacterial gamma-polyglutamic acid super absorbent hydrogel. The antibacterial gamma-polyglutamic acid superabsorbent hydrogel prepared by the invention has good biocompatibility, is safe and non-toxic, also has excellent water absorption performance and antibacterial performance, and has a good application prospect.

The invention provides a plant lactobacillus YH001 with bacteriostatic activity as well as a screening method and application of the plant lactobacillus YH001. The phytobacterium plantarum YH001 has the taxonomic name of Lactiplantibacillus plantarum, is preserved in the Guangdong Microbial Culture Collection Center, and has the preservation number of GDMCC No: 65693, the preservation number of Lactiplantibacillus plantarum YH001 is CGMCC NO: 65693, and the preservation number is CGMCC NO: 65693. The preservation date is December 30, 2024. The strain has excellent biological characteristics of no hemolysis, acid resistance, cholate resistance and the like, and has wide application potential in the fields of food, medicine and the like. The fermentation supernatant still keeps high bacteriostatic activity after being treated at a high temperature of 121 DEG C, and shows excellent thermal stability. Therefore, the strain has a wide application prospect in research and development of antibacterial agents, food leavening agents and preservative products.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The invention discloses a preparation method of ocimum gratissimum carbon dots and application of the ocimum gratissimum carbon dots in antibacterial drugs and food preservation. The preparation method of the ocimum gratissimum carbon dots comprises the following steps: performing steam distillation on ocimum gratissimum leaves to remove essential oil, drying in the shade, and crushing; adding an alcohol solvent into the powder, extracting, filtering, concentrating and drying to obtain an alcohol extract; dispersing the alcohol extract in distilled water, and stirring and pyrolyzing on a heating table; and diluting the pyrolysis product with distilled water, centrifuging, taking supernate, filtering with a filter membrane, dialyzing, and freeze-drying to obtain the carbon dots. The obtained carbon dots have a carbon dot-vesicle coexisting structure, and the average particle size is 5.732 + / -0.5 nm. The prepared ocimum gratissimum carbon dots can be applied to preparation of antibacterial drugs, especially drugs for inhibiting the activity of bacillus cereus and listeria, and the field of food preservation, and have the advantages of being wide in raw material source, simple in preparation method, low in cost, environmentally friendly and the like.

The invention relates to plant lactobacillus and application thereof. Wherein the gene of the molecular marker for the plant lactobacillus has a nucleotide sequence selected from one of the following sequences: (1) a nucleotide sequence as shown in SEQ ID NO: 24; (2) a nucleotide sequence having at least 97%, 98%, 99% or higher homology with the nucleotide sequence as shown in SEQ ID NO: 24; and (3) a nucleotide sequence with one or more nucleotide sequences, such as 1, 2, 3, 4, 5 or more nucleotide substitutions, deletion or insertion, in the nucleotide sequence as shown in SEQ ID NO: 24. The plant lactobacillus provided by the invention is non-toxic, has good biological characteristics, has a good curative effect on prevention and / or treatment of vaginal infection and related diseases, and avoids the problems of increased drug resistance, high recurrence rate and the like caused by use of antibiotic and other antibacterial drugs during treatment of vaginal infection and related diseases.

The invention belongs to the field of polypeptides, and particularly relates to an antibacterial peptide derived from marine microorganisms, an antibacterial composition and application. Based on a deep learning algorithm, five potential antibacterial peptides are mined from a global marine microbiome database, and the five antibacterial peptides are expressed in yarrowia lipolytica. Experimental tests show that the five antibacterial peptides have differentiated antibacterial effects on different bacteria, and the antibacterial peptide shown in SEQ ID NO: 3 can have an obvious inhibition effect on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus, has low hemolysis and has a positive application prospect. The antibacterial peptide disclosed by the invention has the potential of further developing novel antibacterial drugs or antibacterial additives.

The invention discloses an antibacterial peptide as well as a preparation method and application thereof. The antibacterial peptide has an amino acid sequence as shown in any one of SEQ ID NO: 1-11. The antibacterial peptide prepared by the scheme provided by the invention has very strong bacteriostasis and sterilization capabilities on methicillin-resistant staphylococcus aureus and multidrug-resistant escherichia coli, has application potential of becoming an antibacterial agent, a preservative or a disinfectant, and is not easy to generate drug resistance.

The invention provides a marine biological alkali compound. The chemical formula of the marine biological alkali compound is as follows: # imgabs0. The marine biological alkali compound or pharmaceutically acceptable salt thereof can be used for preparing antibacterial drugs or anti-infective drugs. The invention also provides a separation and extraction preparation method or a chemical synthesis preparation method of the marine alkaloid compound or the pharmaceutically acceptable salt thereof, and the preparation method is simple and easy to industrialize. The invention also provides application of the marine biological alkali compound or the pharmaceutically acceptable salt thereof in preparation of antibacterial drugs or anti-infection drugs for human or fish.

The invention discloses a klebsiella pneumoniae bacteriophage vBKpnPGZMUVR2301 and application thereof, and relates to the technical field of biology. The klebsiella pneumoniae bacteriophage vBKpnPGZMUVR2301 is preserved in Guangdong Microbial Culture Collection Center on October 14, 2024, the preservation address is the 5th floor of the building 59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, and the preservation number is GDMCC No: 65268-B1. The bacteriophage keeps stable titer in a wide pH range (4-10) and a temperature interval (4-50 DEG C), and the highest titer can reach more than 109 pfu / mL. The bacteriophage can efficiently split klebsiella pneumoniae. The invention provides powerful technical support for developing novel antibacterial drugs and treatment schemes for klebsiella pneumoniae, and shows wide application prospect and potential clinical value.

The invention belongs to the field of antibacterial peptides, and particularly relates to a marine antibacterial peptide based on machine learning mining and application thereof. The invention discloses a method for mining marine antibacterial peptides based on machine learning, and 10 marine antibacterial peptides are screened, and the amino acid sequence of the marine antibacterial peptides is shown as any one of SEQ ID NO: 1-10. Wherein the Peptide 5 and the Peptide 8 have a broad-spectrum antibacterial characteristic, and the drug-resistant bacteria MIC (Minimum Inhibitory Concentration) of the Peptide 5 and the Peptide 8 is as low as 2-8 mu g / mL and is superior to that of The Peptide 2 and the Peptide 7 belong to strain specific antibacterial peptides, and are highly specific to bacillus subtilis. The antibacterial peptide has a wide application prospect in the field of preparation of antibacterial dressings and antibacterial drugs.

The invention discloses acinetobacter baumannii and application of the acinetobacter baumannii in construction of a mastitis animal model. The acinetobacter baumannii strain is acinetobacter baumannii AbST3475NMG202308, and the preservation number of the acinetobacter baumannii strain is CGMCC (China General Microbiological Culture Collection Center) No.34450 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms). Experiments prove that the acinetobacter baumannii has high pathogenicity and can be used for establishing a typical animal model caused by acinetobacter baumannii infection, the animal model can be specifically a mastitis animal model, and a certain technical support is provided for subsequent research and development of drugs or vaccines; the acinetobacter baumannii can also be used for screening antibacterial drugs and developing diagnostic reagents and vaccines. The method has an important application value.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The invention provides a method for preparing a degradable bone-guided regeneration membrane with an asymmetric membrane layer, which comprises the following steps of: cutting a magnesium metal sheet into a magnesium net or a magnesium bracket with small holes by laser, carrying out heat treatment on the magnesium net or the magnesium bracket by using HF (Hydrogen Fluoride) to obtain a layer of MgF4 coating on the surface, and immersing the magnesium net or the magnesium bracket into a macromolecular solution until a solvent of the macromolecular coating is completely volatilized; then preparing an electrostatic spinning membrane on the surface of the sample: preparing a dense polymer membrane layer containing an antibacterial drug on the surface of the sample close to one side of the fiber tissue by adopting a hot pressing method, or preparing a dense electrostatic spinning ordered fiber membrane which contains an antibacterial nano-drug and is arranged in parallel by adopting an electrostatic spinning method; the designed structure and the used materials can realize an antibacterial function and shield fiber tissues from growing in. The nanofiber membrane which contains osteogenesis promoting substances such as nano-hydroxyapatite or nano-strontium and is conveyed disorderly is prepared on the side close to the bone tissue by adopting an electrostatic spinning technology, and the designed structure and the contained substances can promote osteogenesis.

The invention relates to lactobacillus mucilaginosus and application thereof. Wherein the gene of the molecular marker for fermenting lactobacillus mucus has one of the following nucleotide sequences: (1) a nucleotide sequence as shown in SEQ ID NO: 24; (2) a nucleotide sequence having at least 97%, 98%, 99% or higher homology with the nucleotide sequence as shown in SEQ ID NO: 24; and (3) a nucleotide sequence with one or more nucleotide sequences, such as 1, 2, 3, 4, 5 or more nucleotide substitutions, deletion or insertion, in the nucleotide sequence as shown in SEQ ID NO: 24. The fermented lactobacillus mucus provided by the invention is non-toxic, has good biological characteristics, has good curative effects on prevention and / or treatment of vaginal infection and related diseases, and avoids the problems of increased drug resistance, high recurrence rate and the like caused by use of antibiotic and other antibacterial drugs during treatment of vaginal infection and related diseases.

The application belongs to the field of medicine, and particularly relates to a cell penetrating peptide Phage-Dec and application thereof in antibiosis. The cell penetrating peptide Phage-Dec has excellent cell penetration ability and antibacterial activity, can effectively penetrate the cell membrane, target and inhibit bacterial growth, and thus achieves the purpose of antibiosis. Research shows that Phage-Dec has a significant inhibitory effect on various pathogenic bacteria, and can effectively reduce the reproduction speed of bacteria. The use of the cell penetrating peptide provides a new idea for antibacterial treatment, has a good clinical application prospect, and lays a solid foundation for developing a new antibacterial drug based on a bacteriophage source.

The present invention belongs to the field of biotechnology and pharmaceutical engineering technology, and discloses a functionalized drug-loaded exosome based on milk exosomes, a preparation method thereof, and an application thereof. The functionalized drug-loaded exosomes include a carrier and a water-insoluble drug, and the water-insoluble drug is loaded inside the carrier; wherein the surface of the carrier is loaded with milk exosomes with functionalized molecules, and the functionalized molecule is any one of phosphatidylserine, a molecule capable of macrophage targeting, and a molecule or polymer that enhances the targeting and stability of milk exosomes; the water-insoluble drug is any one of an antibacterial drug, an antitumor drug, and a gene drug. The functionalized drug-loaded exosomes in the present invention can improve the gastrointestinal stability of oral administration and enhance the efficacy against bacterial pathogens; expand the application scope of milk exosomes in the fields of anti-intestinal bacterial infection and food preservation, and the exosome content in milk is very rich, which is convenient for large-scale preparation and has important application value.

Provided are an antimicrobial peptide or a pharmaceutical composition thereof, and the use thereof. The antimicrobial peptide is a new efficient antimicrobial peptide, has the characteristics of small molecular weight, broad antibacterial spectrum, high efficiency, no cytotoxicity, no hemolytic property, high stability, low susceptibility to developing drug resistance, etc., and can kill microorganisms including clinically common drug-resistant strains, bacteria, and fungi. Moreover, the antimicrobial peptide has the advantages of simple structure, easy large-scale synthesis and low cost, and the antimicrobial peptide is expected to replace antibiotics to become a safe, green and efficient ideal antimicrobial agent, and has very wide application prospects in the fields of the preparation of antimicrobial drugs, antimicrobial preparations, antimicrobial products, etc.

The invention discloses a pneumonia-targeted bionic nano system as well as a preparation method and application thereof. The bionic nano system for targeting pneumonia comprises nano particles entrapped with antibacterial drugs and an NK cell membrane coated on the surfaces of the nano particles. According to the invention, a bionic nano system is targeted to a colonization site of bacteria based on the NK cell membrane for the first time, phagocytosis of macrophages is avoided, a mucous layer formed by penetrating bacteria is penetrated, a delivery system for a pneumonia antibacterial drug is developed, and a new thought and a new method are provided for delivery of the antibacterial drug.

The invention belongs to the technical field of microorganisms, and particularly relates to application of marine phycobacterium LZ-14T in production of indole-3-acetic acid. According to the present invention, the interphycobacterium LZ-14T is named as Maricatenella alexandrii gen. Nov., sp. Nov. The present invention discovers that the interphycobacterium LZ-14T can achieve the effect of significantly inhibiting the synthesis of the PSP toxin by releasing the IAA signal molecule under the condition of promoting the growth of the host algae. The new discovery can provide a new theoretical basis for analyzing the generation mechanism of paralytic shellfish poison of alexandrium chainchain and exploring scientific prevention and control of red tide. The invention also finds that the IAA produced by the phycobacterium LZ-14T can inhibit the growth of escherichia coli, and the result lays a foundation for the preparation of new antibacterial drugs.

The invention relates to the technical field of probiotic development and utilization, in particular to a goose source Weissella cibaria F11 and application thereof. The Weissella cibarius F11 is preserved in the China General Microbiological Culture Collection Center on July 11, 2025, and the preservation number is CGMCC NO.35211. The Weissella cibarius F11 has the characteristics of good acid resistance and cholate resistance, and can be used for preparing the acid-resistant and cholate-resistant strain. And the bacillus subtilis has a good inhibition effect on pathogenic bacteria such as escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and salmonella typhimurium, and also has stable acid production capacity and good safety. The Weissella sinus F11 provided by the invention meets the probiotic characteristic standard, the antibiotic resistance spectrum of the Weissella sinus F11 meets the feed probiotic safety standard, the growth of goslings can be remarkably promoted, the death rate and diarrhea occurrence rate of the goslings can be remarkably reduced, and the weissella sinus F11 can be used for preparing feed probiotics. The development potential in the fields of preparation of bacteriostatic and antibacterial drugs, probiotics for poultry feed, feed additives, poultry feed and the like is huge.

The invention belongs to the technical field of biological medicine and nanotechnology, and particularly relates to nanoparticles loaded with curcumin and antibacterial peptide as well as a preparation method and application of the nanoparticles. The nanoparticles loaded with the curcumin and the antibacterial peptide are prepared by the following steps: taking PEI-PLGA and the curcumin as raw materials, and preparing PEI-PLGA-Cur nanoparticles; pEI-PLGA-Cur nanoparticles and the antibacterial peptide are used as raw materials, and the nanoparticles loaded with the curcumin and the antibacterial peptide are prepared. The nanoparticles loaded with the curcumin and the antibacterial peptide provided by the invention have a photodynamic therapy effect, the drug loading capacity of the curcumin in the nanoparticles is relatively high, the loading rate of the antibacterial peptide is relatively large, auxiliary materials are safe, the preparation process is simple, the particle size of the nanoparticles is relatively small and uniform, the blood compatibility is good, the nanoparticles can be used for treating infection of drug-resistant bacteria, and the application prospect is wide. The potential of becoming a novel nano antibacterial drug and the clinical application prospect are realized.

The application discloses a method for transforming any polypeptide sequence into an antibacterial peptide, and belongs to the technical field of bioinformatics. The application develops a hypergraph neural network predictor for predicting the antibacterial activity score of a polypeptide, performs fine-tuning training on a pre-trained protein language model to capture antibacterial peptide sequence features, and trains a strategy network for selecting a to-be-mutated amino acid site in a polypeptide sequence. For any starting polypeptide sequence, the strategy network is first used to select a to-be-mutated amino acid site, then the fine-tuned protein language model is used to give the amino acid type after mutation of the site, and then the hypergraph neural network predictor is used to predict the antibacterial activity score of the sequence after mutation. The process is iteratively executed until an ideal antibacterial peptide sequence output is obtained. The method has the ability to transform any polypeptide sequence into an antibacterial peptide, and the antibacterial activity score of the transformed polypeptide is greatly improved, and can be applied to the actual development of antibacterial drugs, thereby laying a foundation for solving drug-resistant bacterial infections.

The invention belongs to the technical field of medicines, and particularly relates to application of 10-undecylenic acid and polymyxin in preparation of an antibacterial drug, and the antibacterial drug aims at one or more of escherichia coli, salmonella and klebsiella pneumoniae. The antibacterial agent aims at bacteria which are resistant to polymyxin. The bacteria directed by the antibacterial agent are multi-drug-resistant gram-negative bacteria. Through a chessboard method minimum inhibitory concentration test, an in-vitro bacterial growth curve proves that 10-undecylenic acid synergistically enhances the antibacterial activity of polymyxin, and meanwhile, a mouse drug-resistant bacterial infection model test proves that 10-undecylenic acid can effectively enhance the in-vivo effectiveness of polymyxin at the animal level. The invention provides a new application of 10-undecylenic acid in enhancing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of low clinical drug resistance and therapeutic index of polymyxin and the like.

The application discloses a microbial drug sensitivity detection method. The application comprises: loading a microbial database, establishing a corresponding relationship between secondary microbial names and primary categories; loading a drug breakpoint database based on the "antimicrobial drug sensitivity experiment execution standard"; placing a standard culture dish in an image acquisition device to acquire an image, and calibrating an image analysis system with a vernier caliper; inputting sample information to be detected, acquiring and uploading the image; an image analysis system extracts the position of a drug sensitivity paper sheet, identifies the edge of a bacterial inhibition zone and calculates the diameter; the system extracts corresponding drug breakpoint thresholds based on the microbial category, compares the measured diameter and determines the sensitivity classification (S / I / R); and finally, the result is uploaded to a LIS system. The method can realize the automation, standardization and high efficiency of drug sensitivity detection.

Provided are a non-ribosomal antifungal peptide MaAFP1, a preparation method therefor and a use thereof. The molecular formula of the antifungal peptide MaAFP1 is C41H74N18O12, wherein an amino acid sequence from the N-terminus to the C-terminus is (D)Arg-(L)Arg(OH)-(D)Orn-(L)Thr-(D)Orn-(L)Arg(OH)-(D)Tyr. Fermentation is performed by using Metarhizium anisopliae CQMa421, a fermentation broth is collected, and separation and purification are performed by means of ion exchange chromatography and high performance liquid chromatography so as to obtain the antifungal peptide MaAFP1. The structure of MaAFP1 is analyzed by comprehensively using an Edman degradation method, mass spectrometry, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and circular dichroism spectroscopy. By performing an in vitro bacteriostatic test, it is found that MaAFP1 has a good inhibitory effect on a variety of animal and plant pathogenic fungi, and has the value of the development of a novel antibacterial drug.

The invention provides an antibacterial peptide, application of the antibacterial peptide and an antibacterial drug and a preservative prepared from the antibacterial peptide, and belongs to the technical field of biology. The antibacterial peptide is an amino acid sequence as shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3 or an amino acid sequence which has more than 95% of homology with the amino acid sequence as shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The three antibacterial peptides have broad-spectrum antibacterial effects, have obvious inhibition effects on gram-positive bacteria, gram-negative bacteria and fungi, and can be prepared into antibacterial drugs for use. And simultaneously. The antibacterial film agent prepared from the antibacterial peptide can be used as an antibacterial preservative, and can delay proliferation of putrefying bacteria in food or medicines, so that the shelf life of the food or medicines is prolonged, for example, the antibacterial peptide can be used for preventing and treating soft rot of kiwi fruits. The antibacterial peptide has a good application prospect in the fields of food, medicine and the like.

The invention relates to the technical field of antibacterial preparations, and discloses an application of etoposide in an antibacterial preparation and the antibacterial preparation, the antibacterial preparation is a biofilm inhibitor, and etoposide inhibits formation of a biofilm or destroys the formed biofilm by down-regulating gene expression of the bacterial biofilm, so that the antibacterial effect of etoposide is improved. The biofilm is a biofilm of streptococcus mutans ATCC700610, and the biofilm is a biofilm of streptococcus mutans The antibacterial preparation comprises an antibacterial drug, an oral care product, a medical coating and an anti-caries preparation. MIC and MBC determination tests, growth curve tests, crystal violet staining tests, bacterium living / death staining tests and qRT-PCR tests prove that etoposide can effectively down-regulate biofilm related gene expression (such as gtfB, gtfC, gtfD and the like), inhibit formation of a bacterial biofilm or destroy a formed biofilm, and achieve an antibacterial effect.

The invention belongs to the technical field of medicines, and particularly relates to an aryl dicarboxylic acid compound, a preparation method and application of the aryl dicarboxylic acid compound as an antibacterial agent. The compound is shown as a formula (1), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from hydrogen and halogen. Two ends of the molecule are connected through an N-phenylpropanamide connecting arm, the molecule is a compound with a novel structure, and the series of compounds have a relatively strong inhibition effect on acinetobacter baumannii and are worthy of further research and development.