864 results about "Antimicrobial drug" patented technology

An intravaginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device.

An antibacterial 3,5-substituted oxazolidione derivative and its salt with strong activity to resist gram-position bacteria, their preparing process, their application in preparing antibacterial agents and the antibacterial medicine containing them as active components are disclosed.

The invention relates to a method of industrial and artificial breeding of Epinephelus, which is applicable to the breeding of Epinephelus malabaricus and E.coioides. The method comprises the following steps: (1) treating a nursery pond and water; (2) preparing before breeding; (3) putting larval fishes of Epinephelus or germ cells; (4) controlling the quality of the breeding water body; and (5) feeding baits. The method is applied to conduct the industrial and artificial breeding, so that the water quality of the breeding is stable, the output for the unit water body breeding is high, the bred sizes of advanced fries are uniform, no antibacterial drugs are used, no special breeding is conducted to unicellular alga, no bottom-attaching happens in the process of breeding, and the operation is simple.

New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.

The invention provides a new compound and a preparation method and application thereof. The structure of the compound provided by the invention is shown as a formula (1). Four-potential hydroxyl of glycosyl on benzyl hydroxyl of peptide framework six-potential amino acid of the compound serves as an axial bond and the compound is obtained by fermentation and has the collection number of China General Microbiological Culture Collection Center (CGMCC) No.3053. The compound provided by the invention has high antibiotic activity, so that the compound plays a very important role in developing a new antibacterial medicament.

The invention belongs to the technical field of determination of antibacterial drug residues in water environment, and in particular relates to a method for simultaneous determination of 92 antibacterial drug residues in the water environment. The method includes an improved solid phase extraction-liquid chromatography-tandem mass spectrometry determination method, and in particular includes (1) water sample pretreatment; (2) use of solid phase extraction for enrichment of various antibacterial drugs in a water sample; and (3) liquid chromatography-tandem mass spectrometry determination method establishment. The sample is fed by one time, can simultaneously determine 92 antibacterial drugs, reduces the detection cost, and improves detection efficiency, and is suitable for the detection of antibacterial drug residues in high flux water environment.

The invention provides a new chitosan derivate-chitosan biguanide muriate, its preparation and usage, in which, the repeat unit is 2-biguanide glucose muriate, the substitution degree of guanidine is 15-50%, and the molecular weight is 0.5-25 ten thousand. This invention uses the reaction of chitosan and dicyandiamide to prepare chitosan biguanide muriate, and has advantages of mild reaction conditions and fewer side effects. The product has good antibacterial activity and water solubility, and can be widely used in medicine, textile industry, agriculture and other fields.

The invention discloses a preparing method of east Asia Tityus antibiotic peptide gene and appliance, which comprises the following steps: restructuring bacillus coli Escherichia coli DH5a/BmKAMP1, CCTCC NO: M207036; constructing east Asia Tityus ioterium cell cDNA library; choosing PCR method; sieving positive colony of scorpion antibiotic peptide gene from ioterium cDNA library; sequence-analyzing coding trait of antibiotic peptide gene; assuring amino acid sequence of the antibiotic peptide gene; adopting chemosynthesis antibiotic peptide; possessing inhibition of diverse density for Gram's bacterium. This antibiotic peptide possesses specificity and high active, which can be used as antibacterial drugs.

The invention discloses an externally used nanometer silver antibiotic jel line products, which is characterized by the following: constituting with acceptable shaped agent, diluent, slow releasing agent, disperser on nanometer silver and medicinal; setting the grain size of the nanometer silver at 1-25nm; comprising push injecting agent, foam spray, aquagel cleaning solvent, spray and so on of nanometer silver antibiotic jel line products. This invention also relates to the preparing method of nanometer silver colloid and nanometer silver antibiotic jel line products. This product can be used to cure vaginitis, cervicitis, mixing infection type gynaecologic inflammation, prostatitis, prostate proliferation, prostatauxe, male urethritis, balanitis, posthitis and so on.

This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.

The present invention relates to compositions and methods for treating pathological infections. An embodiment of the present invention is directed to a topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment which includes a pharmaceutically effective amount of an anti-yeast, anti-fungal or antibacterial pharmaceutically active agent; and a pharmaceutically acceptable carrier.

Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mammalian cells. The biologically active compound or prodrug is linked to a microparticle with a linker that is non-specifically or specifically cleaved inside a phagocytic mammalian cell. Alternatively, the biologically active compound or prodrug is impregnated into a porous microparticle or coated on a nonporous microparticle, and then coated with a coating material that is non-specifically or specifically degraded inside a phagocytic mammalian cell. The prodrug contains the biologically active compound linked to a polar lipid such as ceramide with a specific linker such as a peptide that is specifically cleaved to activate the prodrug in a phagocytic mammalian cell infected with a microorganism. A microparticle linked antimicrobial drug or prodrug may be used for killing a microorganism infecting a phagocytic mammalian cell in vivo or in vitro.

The invention provides a super-hydrophilic coating with a long-acting antibacterial property and a preparation method thereof. The preparation method comprises the following steps that the surface ofa substrate material is pretreated; the pretreated substrate material is put into a slight acidic buffer solution, then a polyphenolic substance, a multi-amine compound, an antibacterial agent and anoxidizing agent are added to react; a reaction product is immersed in deionized water, ultrasonic cleaning is carried out, then drying is carried out under a nitrogen condition to prepare the coating.The super-hydrophilic coating with the long-acting antibacterial property and the preparation method thereof have the advantages that the operation is simple, the reaction condition is mild; the prepared coating material contains the polyphenolic substance, and a large number of carboxyl, phenolic hydroxyl group, quinonyl, amidogen and other functional groups and metal ions or agents which has the antibacterial property, so that the metal ions and the antibacterial agents achieve the long-term existence of the antibacterial agent through the mutual effect with the phenolic hydroxyl group function group or the accumulation of a pi-pi system. The coating can be applied to the preparation of wound dressing materials in the field of medical materials.

The invention relates to a bursin extracting method and its application to curing disease and immunity, having important value in application in the aspects of heightening organismal immunity and acting as immunoenhancer, heightening effect of vaccine, etc., and able to heighten body fluid and cell immune functions of mammal at the same time. It can be used to prevent and cure infectious diseases and young animal diseases singly or together with other drugs such as antivirus and antibacterial drugs or immunomodulators, also be applied to animal vaccine as adjuvant or immunoenhancer to strengthen the disease-resistant ability and immunoresponse ability to peculiar antigens, thus heightening the immune effect.

The invention relates to a hernia patch solid-supported with antibiotics and a preparation method. The antibiotic hernia patch solid-supported with drug-loaded microspheres comprises drug-loaded microspheres, a patch, and a supporting agent. The sandwich-type antibiotic hernia patch comprises a patch layer, a drug layer, and a film layer. The antibiotic hernia patch solid-supported with drug-loaded microspheres is prepared by solid-supporting the drug-loaded microspheres onto the surface of the patch material by the supporting agent. The drug-loaded microspheres are loaded with water-soluble drugs by a solvent evaporation method. The sandwich-type antibiotic hernia patch is prepared by sandwiching the drug layer between the patch layer and the film layer through a layer-by-layer superposition principle. The antibiotic hernia patch of the invention has a simple and practical preparation method, is suitable for different clinical medication requirements, has obvious slow release performance, has significant antibiotic effect in rats, solves the problem of acute and delayed infection after herniorrhaphy, has good market prospects, and is worthy of popularization and utilization.

A preparation method of sulfadoxine belongs to the field of sulfanilamide antimicrobial drug preparation. Cyclization reaction comprises the following steps of: firstly pouring a sodium methoxide solution into a reactive pan, then successively adding methanamide and methyl ethyl methoxymalonate, keeping warm, recovering methanol, cooling for crystallization, drying by centrifugation, discharging,and drying to obtain 5-methoxy-4,6-disodium dihydroxypyrimidine; Chlorination reaction comprises the following steps of: firstly putting phosphorus oxychloride into a reaction vessel for heating, adding 5-methoxy-4,6-disodium dihydroxypyrimidine into the reaction vessel to react, decompressing and recovering phosphorus oxychloride until the material is dry, cooling, adding trichloro ethylene withuniformly stirring, putting into a hydrolysis pan for hydrolyzation, collecting a trichloro ethylene layer after standing and delaminating, followed by a neutralization reaction, controlling pH value, washing, removing a water layer, recovering trichloro ethylene, and releasing crystals to obtain 5-methoxy-4,6-dichloropyrimidine. The preparation method provided by the invention can be used to guarantee the product purity, prolong the service life of equipment, avoid the damage to the environment and human body, reduce emission, and save energy, and accords with foreign pharmacopoeia standard requirements.

The present invention relates to synthesis process and medicinal use of o-dihydroxyflavone-selenium complex. The o-dihydroxyflavone-selenium complex in the structure as shown may be applied in preparing health product, pesticide, plant growth regulator, feed additive, immunomodulator, antitumor medicine, antibacterial medicine, etc.

The present invention discloses the new use of available antimalarial arteannuin and its derivatives dihydro arteannuin, antiannuic methyl ether, antiannuic ethyl ether and antiannuic amber. Arteannuin and its derivatives are used through combination with antibiotic medicine to inhibit bacterial growth and enhance the antibiotic effect of available antibiotic medicine. Especially, antiannuic amber is applied in preventing and treating bacterial infection diseases except being used as antimalarial.

The present invention relates to methods and compositions for improved efficacy and delivery of time-dependent antimicrobial drug compositions to a patient. Transdermal dosage forms and methods for steady-state delivery of drug to produce and maintain a serum concentration of drug above the minimum inhibitory concentration or minimum microbicidal concentration are provided.

The invention relates to a preparation method of effective fractions of shining wintersweet leaf, a preparation method and a use of a preparation thereof, in particular to an application of the effective fractions of the shining wintersweet leaf and the preparation thereof in drugs used for preventing and treating respiratory system diseases as well as in anti-cold drugs, antimicrobial drugs, anti-inflammation drugs, antiviral drugs, antifungal drugs, etc. In the invention, the volatile effective fractions and non-volatile effective fractions are added to the crude drug of the shining wintersweet medicinal material with a weight ratio of the actual extraction amount of the shining wintersweet to the effective fractions being 1.0-2.6:0.5-3.5, thus the effective fractions of the shining wintersweet leaf are obtained. A preparation of the effective fractions of the shining wintersweet can be made into granules, soft capsules, capsules, drop pills, tablets, compound capsules, dispersible tablets, etc. In the invention, the preparation of the shining wintersweet is deeply developed, which ensures that the preparation is rich in active ingredients, has definite effective ingredients, obvious pharmacological action and significant improvement of drug action. Besides, the preparation has stable performance and controllable quality, is safe and reliable, has less dosage, and is favorable for transportation and storage of the medicine as well as for patients to take.

The invention relates to dihydroisoquinoline compounds and an application of the dihydroisoquinoline compounds for preparing antibacterial agents for plants. The dihydroisoquinoline compounds have remarkable bacteriostatic activity on various phytopathogens. The dihydroisoquinoline compounds disclosed by the invention have the molecular structure characteristics shown as follows, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are same or different groups, such as hydrogen, alkyl, cycloalkyl, alkenyl, alkinyl, unsaturated monocycloalkyl, alkoxyl, halogen, hydroxyl, nitryl, cyano, trifluoromethyl, heterocyclic substituent, carboxyl, ester group, acylamino, acyl or aldehyde group; and X<-> is sulfate radical, halogen anion, carbonate radical, bicarbonate radical, phosphate radical, hydrophosphate radical, acid radical of fatty acid, sulfonate radical or tetraphenylborate radical.

The invention relates to a purely Chinese traditional medical film for curing oral ulcer, which is characterized in that according to weight percentage, the purely Chinese traditional medical film consists of 0.03-0.05g of allicin, 2-4g of catechu, 1-2g of borneol, 0.5-1.5g of borax, 0.5-1.5g of corn mint, 1-3g of gum tragacanth, 30-40ml of sodium alginate, 4-5ml of sodium carboxymethylcellulose, ethanol and 100ml of distilled water. The purely Chinese traditional medical film is completely purely Chinese traditional medical formula, is the best formulation for curing ulcer of oral mucosa, avoids side effects caused by using antibiotics and glucocorticoid, and has the advantages of obvious curative effect, convenient use, small side effect and curing cause and symptom.

The invention provides a synthetic method of a berberine 13-bit derivant and a berberrubine 13-bit derivant. The synthetic method is used to prepare derivants as follows: 13-benzyl berberine, 13-(2',4'-binitro) benzyl berberine, 13-benzyl berberrubine and 13-(2', 4'-binitro) benzyl berberrubine, which show excellent inhibiting effect on gram-positive bacterium, wherein the value of minimal inhibitory concentration (MIC) of the berberine is 64mug/ml, the value of MIC of the berberrubine is larger then 128mug/ml, the values of MIC of the 13-benzyl berberine, the 13-(2',4'-binitro) benzyl berberine, the 13-benzyl berberrubine and the 13-(2',4'-binitro) benzyl berberrubine are respectively 32mug/ml, 16mug/ml, 32mug/ml and 8mug/ml. The synthetized derivants, the antimicrobial activity of whichis better than matrixes, can be used as raw materials of antimicrobial drugs.