160 results about "Chemosynthesis" patented technology

The invention discloses a hydroxylated tung oil and an ester group-aminated preparation method, belonging to the technical field of organic chemosynthesis. In the method, under a certain condition, ester groups in the tung oil and diethanol amine are subjected to aminolysis reaction on the premise of reserving conjugated double bonds, thus the tung oil is hydroxylated to mainly produce a compound containing terminated hydroxyl and three conjugated double bonds. The structural formula of the compound is shown in the specification. The aminolysis reaction product plays an important role in developing and producing processes of leading the tung oil into waterborne polyurethane, not only can combine the advantages of the tung oil and the polyurethane, but also can improve the utilization ratio of tung oil resources as special local products in China and decrease the dependence on petroleum products; and simultaneously, the method has the advantages of simplicity, practicability, high conversion rate and convenience in industrialized production.

The invention discloses a method for synthesizing nanometer ZSM-5 molecular sieve, which belongs to the technical field of inorganic chemosynthesis. The method comprises steps as follows: sodium metaaluminate or aluminium sulphate, silica sol or water glass, sodium hydroxide and isopropylamine are prepared into reaction mixer; the reaction mixer is subjected to hydrothermal crystallization; and the reaction mixer after the hydrothermal crystallization is filtered, washed, dried and baked conventionally to obtain nanometer ZSM-5 molecular sieve. The synthesized ZSM-5 molecular sieve has the advantages of higher specific surface, short production flow and low cost, and the section of the synthesized ZSM-5 molecular sieve crystal grain has an average diameter not larger than 100 nm, thereby facilitating industrialization production and application.

The invention discloses a preparing method of east Asia Tityus antibiotic peptide gene and appliance, which comprises the following steps: restructuring bacillus coli Escherichia coli DH5a/BmKAMP1, CCTCC NO: M207036; constructing east Asia Tityus ioterium cell cDNA library; choosing PCR method; sieving positive colony of scorpion antibiotic peptide gene from ioterium cDNA library; sequence-analyzing coding trait of antibiotic peptide gene; assuring amino acid sequence of the antibiotic peptide gene; adopting chemosynthesis antibiotic peptide; possessing inhibition of diverse density for Gram's bacterium. This antibiotic peptide possesses specificity and high active, which can be used as antibacterial drugs.

The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon dioxide and/or other forms of inorganic carbon into organic chemicals including biofuels or other useful industrial, chemical, pharmaceutical, or biomass products. One or more process steps utilizes chemoautotrophic microorganisms to fix inorganic carbon into organic compounds through chemosynthesis. An additional feature described are process steps whereby electron donors used for the chemosynthetic fixation of carbon are generated by chemical or electrochemical means, or are produced from inorganic or waste sources. An additional feature described are process steps for the recovery of useful chemicals produced by the carbon dioxide capture and conversion process, both from chemosynthetic reaction steps, as well as from non-biological reaction steps.

The invention discloses a method for preparing an attapulgite/ionic liquid composite material. The method utilizes ionic liquid molecules with a designable molecular structure to modify attapulgite and provides a novel approach for increasing the compatibility between the attapulgite and diverse organic solvents. The method bonds a functionalized ionic liquid containing a carboxyl functional group on the surface of the attapulgite through a covalent bond, and utilizes anion exchange to change hydrophilic and hydrophobic properties of the attapulgite. The preparation process and the preparation method are simple. The attapulgite composite material with controllable solubility and is modified by the ionic liquid is expected to be applied in the field of catalysis, sensors, novel nanometer materials, chemosynthesis, water treatment, food processing, mining, drug synthesis and so on.

This invention relates to a method for preparing 4A zeolite with kaoline as the raw material aiming at providing a preparation method for composite 4A zeolite with kaoline as the raw material against the shortcomings of the present chemosynthesis method, acidified bentonite method and a kaoline high temperature calcining method including the following steps: mixing uniformly kaolin and NaOH in a certain proportion and heating them for 1-3h, adding a certain volume of active Al2O3, active SiO2 and water in the activated product to be thermal-crystalized for 0.5-4h under 80-95deg.C then to filter the product and dry it to get the 4A zeolite product.

The invention relates to a bursal pentapeptide, and the structural sequence of amino acid of the bursal pentapeptide is Cys-Lys-Asp-Val-Tyr. The bursal pentapeptide (Bp5) has simple structure, small molecular weight, no chemical toxicity and no immunogenicity, is easy to be prepared, and can not only be extracted from the bursa of fabricius of chicken or other poultry, but also be prepared by chemosynthesis with quite low cost in large-scale. The bursal pentapeptide (Bp5) can promote the multiplication of T lymphocyte and B lymphocyte, improve the humoral immunity level and cellular immunity level of an organism as well as the capability of anti-peroxidation stress of the organism, is a medicament or preparation with wide application prospect and the functions of immunoregulation, immunotherapy and anti-peroxidation, and can be applied to the fields such as fundamental research, clinical treatment, nutrition and health care, cosmetics, and the like.

A method for using straw raw materials to ferment and produce succinic acid belongs to the technical field of biological engineering. The invention takes straws as raw materials and obtains hydrolysis straw syrup of hexose and pentose through hydrolysis treatment, and then succinic acid actinobacillus CGMCC 1593 is used to ferment and produce the succinic acid in culture medium of the hydrolysis straw syrup which contains reducing sugar. The microorganism CGMCC 1593 of the invention which is obtained through screening from paunches is fed-batched and anaerobically fermentted for 48 hours in a 5L-25L fermenter under the anaerobical circumstance whose pH is kept within 5.5-7.5. The concentration of total reducing sugar which is invested is 68.6-70.9g/L, the concentration of the succinic acid which is produced is 49.5-52.1g/L, the yield of the succinic acid to consumption suger is 80.0%-81.2%( the availability ratio of the sugar is 87.3-93.6%), and the production intensity is 1.03-1.09g/(L h). The invention has the prominent advantages that the raw materials of agricultural wastes straws are utilized to ferment and produce the succinic acid, the method is a producing method which uses renewable raw materials and is environmental friendly, and the problem of petrifaction resources tension of chemosynthesis succinic acid can be alleviated.

The invention relates to a water-soluble polymer adsorption material of a coupling cyclodextrin in the field of biomedical materials and an application thereof. The adsorption material comprises a coupling ligand which takes natural polysaccharide with amino or hydroxyl and derivatives thereof or chemosynthesis polymer as carriers and is characterized in that the molecule of the polymer adsorption material has the structure of formula (I). In the formula, R is chosen from natural polysaccharide with amino or hydroxyl and derivatives thereof or chemosynthesis polymer with the viscosity average molecular weight between 6KD and 500KD; X is chosen from C0-C6 alkane chain with O atom, N atom or OH group; CD is chosen from Beta-cyclodextrin or substitutional Beta-cyclodextrin. The adsorption material dissolved into a medical dialyzate can be applied to blood purification treatment for grave hepatitis patients. The adsorption material of the invention has the advantages of removing small molecular protein bound toxin and water soluble toxin molecular at the same time, low treatment cost which is only about one tenth of that of a molecular adsorption recycling system and low non-specificity adsorption of plasma protein.

The invention relates to a novel method of synthetizing levo-praziquantel. High solid, locus and regioselectivity of enzyme are utilized to catalyze chemosynthesis racemic modification or a certain enantiomer of a derivative to conduct dynamic kinetic splitting and producing an optical homochiral levo-praziquantel midbody, and further the levo-praziquantel is obtained through various mature and high-yield conventional organic chemical reactions. The method is mature in process and low in cost, can be used for producing levo-praziquantel in mass, improves quality standard, establishes foundations for creating quality raw material medicine and preparation, and solves the industrial difficulty of purifying praziquantel which is suspended and unsolved for nearly 30 years. Raw materials can be easily obtained, and product purity can be higher than 98%.

The invention relates to a new method of stereo selectivity synthesis drospirenone and main intermediate in the synthesizing method; 15 Beta, 16 Beta-methylene dehydroepiandrosterone (3 Beta-hydroxy-15Beta, 16Beta-methylene -androstane -5-ene-17-ketone, 2) are adopted as starting raw material for the methods and the drospirenone is synthesized via fourteen steps. The invention has the advantages of higher yield and good stereo selectivity.

The invention relates to the field of chemosynthesis, a trihydrate 3-aminopropyl amine ethyl thiophosphoric acid(amifostine)stable crystal and a preparation method thereof. The method comprises the following steps: step one, according to the molar ratio of between 1.01 to 1.0 and 1.2 to 1.0, N-(2-bromethyl)-1,3-propane diamine bi-hydrobromide and sodium thiophosphate are dissolved in water, are added with a polar aprotic solvent as an accelerant and react at a temperature of between 10 and 40 DEG C; after reaction, the mixture is directly cooled to precipitate a coarse product of trihydrate amifostine; step two, the coarse product of the trihydrate amifostine obtained in the step one is subjected to primary recrystallization and purification, is dissolved in the water and is precipitated out through methanol to obtain anhydrous amifostine; and step three, the anhydrous amifostine obtained in the step two is subjected to secondary recrystallization and purification, is dissolved in the water and is decolored through active carbon; and the trihydrate amifostine crystal is precipitated out through ethanol. The purity of the crystal is more than or equal to 99.5 percent; the content of mercaptan is less than or equal to 0.1 percent; the content of other relevant substances is less than or equal to 0.1 percent; and a product is stable and is suitable for scale production.

The invention discloses a preparing method of HaiNan speckle equal scorpion antibiotic peptide gene and appliance, which comprises the following steps: restructuring bacillus coli Escherichia coli DH5a/ImAMP1, CCTCC NO: M207034; constructing HaiNan speckle equal scorpion ioterium cell cDNA library; designing primer; choosing PCR method; sieving positive colony of scorpion antibiotic peptide gene from ioterium cDNA library; sequence-analyzing coding trait of antibiotic peptide gene; assuring amino acid sequence of the antibiotic peptide gene; adopting chemosynthesis antibiotic peptide; possessing inhibition of diverse density for Gram's bacterium. This peptide can be used to medicine to prevent and cure Gram's bacterium.

The invention discloses a preparation method of a solid-acid catalyst, belonging to the technical field of chemosynthesis. The method comprises the following steps: selecting a polythiol compound to react with a polyisocyanates compound to obtain polythiocarbamide resin with free sulfhydryl; oxidizing the polythiocarbamide resin by hydrogen peroxide; and converting the sulfhydryl into a sulfo group so as to obtain sulfo group functionalized polythiourea resin, i.e. the novel solid-acid catalyst. The solid-acid catalyst has the advantages that the thermostability is high, and the thermal decomposition temperature is above 150 DEG C; the acid value is high, wherein the acid value is more than 1-6mmol/g; the synthetic cost is low; the catalytic effect is good; the solid-acid catalyst has high catalytic activity in common acid catalyzed reactions such as esterification, condensation, alkylate, etherification, ester exchange and the like; and the solid-acid catalyst can be reused for many times.

The present invention provides practical GOTCAB saponin synthesis process. The synthesis process includes the following steps: connecting site-28 glucose chain; connecting site-3 glycosyl; connecting rest site-3 glycosyl after protecting radical operation; making site-6' hydroxy group empty via protecting radical operation; selectively oxidizing site-6' primer hydroxy group into carboxylic acid; and finally eliminating all the protecting radicals under alkali condition.

The invention discloses preparation methods and applications of a benzylpenicilloic acid artificial antigen and a benzylpenicilloic acid artificial antibody, and relates to a method for simply, quickly and effectively detecting penicillin G and a degradation product of penicillin G, namely benzylpenicilloic acid. The specific antibody to penicillin G and the degradation product of penicillin G, namely benzylpenicilloic acid, is prepared by designing and synthesizing a hapten and the artificial antigen of a penicillin veterinary drug penicillin G with a 6-aminocaproic acid molecular structure and a beta-lactam ring molecular structure, and the degradation product of penicillin G, namely benzylpenicilloic acid; a molecular specific antigenic determinant of the veterinary drug is highlighted; the chemosynthesis difficulty is overcome; and an immune animal induces to generate the specific antibody with very high affinity.

The invention relates to the method for producing long-acting thymus peptide 1 derivant and its salt for medical use, and the usage of them. The long-acting thymus peptide derivant is consisting of thymus peptide derivant and carbowax with covalent links, of which the structure is showed as the instruction defined. The prosoma thymus peptide 1 derivant modifying carbowax can be produced by the means of chemosynthesis and restructuring DNA.

The invention belongs to the field of articles for daily use and in particular relates to a manufacturing method of honey lip balm; barbados aloe is firstly cut into pieces, and then is boiled out when being added with water properly, clarifying filtration is carried out, and the filtrate is concentrated to obtain barbados aloe extract; vitamin B2 is dissolved with proper water, vitamin E is ultramicro-crushed; Vaseline with a certain quantity is weighted and is melted, and then the honey, the barbados aloe extract, the vitamin B2 and the vitamin E are added according to the proportion, the mixture is stirred and is mixed uniformly; the mixture is cooled and condensed, and then is packaged to obtain the product. The raw materials adopted by the invention are pure natural plant extracts and no harmful chemosynthesis substance is contained, therefore, the product can not harm to human health, and the application range is wide.

The invention discloses a Thomsen-Friedenreich (TF) antigen and a TF antigen analogue and their chemoenzymatic synthesis method and use. The chemoenzymatic synthesis method comprises the following steps of 1, carrying out chemosynthesis of fluorogalactose and a fluoro-galactosamine analogue, 2, carrying out enzymatic synthesis of a fluoro-TF antigen, and 3, carrying out enzymatic synthesis of a sialyl TF antigen. The preparation method has flexibility of a chemosynthesis method, and high regioselectivity and high efficiency of an enzymatic synthesis method, creatively realizes enzymatic synthesis of the fluoro-TF antigen, and solves the problem that the existing fluoro-TF antigen chemosynthesis method has low substrate reactivity, complex synthesis steps and a low yield. A tumor-associated fluoro-carbohydrate antigen is superior to a natural carbohydrate antigen in pharmacokinetic properties and thus the preparation method has wide application prospects in development of a novel anti-tumor vaccine.

This invention has offered a chemosynthesis method to AE-activity ester, using ATMAA, dibenzthiazole sulfide, triphenylphosphine as raw materials, in existing of catalyst, after sufficient response of the organic solvent, filter the reaction solution, filter cake is washed and dried to get stated AE-activity ester, join di(trichloromethyl)carbonic acid ester in filtrate, the reaction gets dibenzthiazole and triphenylphosphine, stated benzthiazole sulfide and triphenylphosphine can be recycled after being retrieved. This invention has advanced craft route, rational process conditions, cheap and easy getting raw materials, simple and safe operation.

The invention discloses an Exendin-4 derivant with Exendin-4 activity and preparation and application thereof, belonging to the technical field of biological engineering. The molecular structural formula of the derivant is any one of the following structures: Exendin-4(1-39)-Xaa40(Seq ID No.2), Exendin-4(1-39)-Xaa40-Xaa41(Seq ID No.3), Exendin-4 (1-39)-Xaa40-Xaa41-Xaa42(Seq ID No.4), Exendin-4(1-30)-Xaa31(Seq ID No.6), Exendin-4(1-30)-Xaa31-Xaa32(Seq ID No.7) and/or Exendin-4 (1-30)-Xaa31-Xaa32-Xaa33(Seq ID No.8); wherein, Xaa40, Xaa41, Xaa42, Xaa31, Xaa32 and Xaa33 are respectively any amino acid of Cys, Ala, Gly, His, Ser and Thr. The Exendin-4 derivant has the advantage that the derivant has longer in-vivo drug effect time than Exendin-4. Solid phase chemosynthesis is adopted to prepare the Exendin-4 derivant, so that production steps are few and production cost is low. The Exendin-4 derivant is particularly suitable for preparing the active ingredient of drugs for curing diabetes.