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Water-soluble polymer adsorption material coupling cyclodextrin and uses thereof

An adsorption material, cyclodextrin technology, applied in the field of biomedical materials, can solve the problems of high treatment cost, reduced pathogenic factor removal ability, high cost, avoid non-specific adsorption, improve blood compatibility, and fast adsorption speed Effect

Active Publication Date: 2008-12-17
康元大工生物技术(大连)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the equipment of this system is relatively complicated, and the cost of modified powdered activated carbon and cationic resin is relatively high, resulting in high treatment costs.
[0007] In summary, the current blood purification methods for severe hepatitis mainly have the following two deficiencies: 1) The solid adsorbent for hemoperfusion binds to the pathogenic factor through electrostatic or hydrophobic interactions. When in contact with blood, some essential components of the human body such as plasma proteins can also be adsorbed to the surface of the solid adsorbent through the above two effects. 2) The treatment equipment is complicated and the treatment cost is expensive
Hemoperfusion systems generally require two sets of plasma separators and adsorption columns, while MARS and Biologic-DT systems are more complicated, resulting in higher treatment costs

Method used

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  • Water-soluble polymer adsorption material coupling cyclodextrin and uses thereof
  • Water-soluble polymer adsorption material coupling cyclodextrin and uses thereof
  • Water-soluble polymer adsorption material coupling cyclodextrin and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. Synthesis of water-soluble starch coupled with β-cyclodextrin and its application in blood purification

[0029] The first step is to prepare the adsorbent material

[0030] Weigh 10 grams of starch with a viscosity average molecular weight ranging from 400 to 500KD and put it into a flask, add 100ml of 1mol / L sodium hydroxide, 5ml of dimethyl sulfoxide, and 3ml of epichlorohydrin to it, and then react at 30°C After 5 hours, epoxy-activated starch was obtained. Add 3 grams of β-cyclodextrin to the reaction system, react

[0031]

[0032] night. After filtering, washing and drying, the product is obtained. The reaction formula is as follows:

[0033] n=2469~3087 (corresponding to the starch molecular weight range of 400~500KD).

[0034] The second step, the preparation of dialysis adsorption solution

[0035] 1 gram of water-soluble starch coupled with β-cyclodextrin was dissolved in 1000 ml of lactate dialysate to prepare an adsorption dialysate with...

Embodiment 2～6

[0039] Examples 2-6. Other polysaccharide derivatives containing hydroxyl groups and synthetic polymers react with substituted β-cyclodextrins to prepare adsorption materials and their applications

[0040] Using the same reaction method, the reaction in Example 1 is also applicable to coupling substituted β-cyclodextrin on hydroxymethyl starch, hydroxyethyl starch, hydroxypropyl starch, dextran and polyvinyl alcohol. Their consumption and reaction conditions are identical with embodiment 1. The corresponding reactants and product structures are shown in the table below. Since their common feature is that there are cyclodextrin groups on the polymer backbone, they have the same function.

[0041]

[0042] The water-soluble polymer coupled with cyclodextrin synthesized by the above method was prepared into an adsorption dialysate by the same preparation method as in Example 1, and applied to simulated adsorption dialysis experiments in vitro. Similar effects were obtained ...

Embodiment 7

[0043] Example 7. Synthesis and application of water-soluble chitosan coupled with sulfobutyl-β-cyclodextrin

[0044] The first step is to prepare the adsorbent material

[0045] Weigh 10 grams of chitosan with a viscosity average molecular weight ranging from 90 to 100KD and put it into a flask, add 100ml of 1mol / L sodium hydroxide, 5ml of dimethyl sulfoxide, and 3ml of epichlorohydrin to the flask, and then heat it at 30°C Under reaction for 5 hours, epoxy-activated chitosan was obtained. Add 3 g of sulfobutyl-β-cyclodextrin to the reaction system and react overnight. After filtering, washing and drying, the product is obtained. The reaction formula is as follows:

[0046]

[0047] n=559-622 (corresponding to chitosan molecular weight range of 90-100KD).

[0048] The second step, the preparation of dialysis adsorption solution

[0049] 1 gram of water-soluble chitosan coupled with sulfobutyl-β-cyclodextrin was dissolved in 100 ml of acetate dialysate to prepare an ad...

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Abstract

The invention relates to a water-soluble polymer adsorption material of a coupling cyclodextrin in the field of biomedical materials and an application thereof. The adsorption material comprises a coupling ligand which takes natural polysaccharide with amino or hydroxyl and derivatives thereof or chemosynthesis polymer as carriers and is characterized in that the molecule of the polymer adsorption material has the structure of formula (I). In the formula, R is chosen from natural polysaccharide with amino or hydroxyl and derivatives thereof or chemosynthesis polymer with the viscosity average molecular weight between 6KD and 500KD; X is chosen from C0-C6 alkane chain with O atom, N atom or OH group; CD is chosen from Beta-cyclodextrin or substitutional Beta-cyclodextrin. The adsorption material dissolved into a medical dialyzate can be applied to blood purification treatment for grave hepatitis patients. The adsorption material of the invention has the advantages of removing small molecular protein bound toxin and water soluble toxin molecular at the same time, low treatment cost which is only about one tenth of that of a molecular adsorption recycling system and low non-specificity adsorption of plasma protein.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a water-soluble polymer adsorption material coupled with cyclodextrin for removing various small and medium molecular toxins in blood, and the application of the adsorption material to blood. method of dialysis. Background technique [0002] Severe hepatitis, liver insufficiency and liver failure caused by various reasons are very common in our country. Liver failure, whether caused by acute onset or acute exacerbation of chronic liver disease, is always a clinical syndrome that seriously threatens the lives of patients. Its main manifestation is the accumulation of a large number of metabolic toxins in the body, including blood ammonia, bilirubin, bile acids, etc., which can cause various serious complications. [0003] At present, blood purification therapy is used to remove metabolic toxins in the blood of patients with liver diseases, especially protein-bound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26A61M1/36
Inventor 贾凌云王智谢健
Owner 康元大工生物技术(大连)有限公司
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