38 results about "Hemoperfusion" patented technology

The invention discloses an automatic flushing device for a hemoperfusion device, and relates to the technical field of medical instruments. Comprising a base and a flushing structure, a vertical frame is arranged at the top of the base, and a flushing fluid box is arranged on one side of the vertical frame; the vertical frame is further provided with a lifting structure and a lifting table, and the lifting table is installed on the lifting structure. A back plate is arranged at the top of the lifting table; the flushing structure is mounted on the side surface of the back plate; a pump machine is arranged in the flushing fluid tank, a fixing pipe is arranged at the output end of the pump machine, penetrates through the top of the flushing fluid tank and is provided with a connecting port, the connecting port is provided with a flushing fluid feeding pipe, and the other end of the flushing fluid feeding pipe is connected with the flushing structure; the top of the base is further provided with a waste water barrel, and the flushing structure is further provided with a waste liquid collecting pipe. The device is compact and reasonable in overall structure and easy to operate and understand, the workload of medical staff can be remarkably relieved, the medical resource utilization efficiency is improved, and the device has important clinical application value and popularization prospects.

The invention discloses a blood perfusion adsorbent for adsorbing endotoxin by double acting forces as well as a preparation method and application of the blood perfusion adsorbent. The adsorbent (PS-DVB (at) p (CD-His)) is subjected to raft polymerization through 4-cyano-4-(thiobenzoic acid) valeric acid grafted on the surface of PS-DVB to generate a glycidyl methacrylate brush polymer, and is combined with an L-histidine modified cyclodextrin functional molecule; the positive charges of histidine groups and the hydrophobic cavities of the cyclodextrin are used for realizing electrostatic and hydrophobic interaction to synergistically and efficiently adsorb endotoxin. The materials of the blood perfusion adsorbent are easy to obtain, the cost is low, the blood perfusion adsorbent has good blood compatibility and endotoxin adsorption performance, the development of the adsorbent is beneficial to in-vitro blood perfusion treatment of septicopyemia patients, and the clinical treatment cost is reduced.

1. The name of the design product: blood perfusion device. 2. The use of the design product: for blood purification treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model discloses a medical-grade purification treatment device for a blood perfusion adsorbent, and belongs to the technical field of blood purification. A closed mesh enclosure for containing an adsorbent is arranged in an inner cavity of the extraction column; an upper joint and a lower joint which are communicated to the inner cavity as well as a feeding pipe and a discharging pipe which are communicated to the mesh enclosure are mounted on the extraction column; the liquid storage tank is used for containing a purification solvent; the liquid storage tank is connected with the circulating pump, the circulating pump is connected with the filter, the filter is connected with the evaporator, the upper connector and the lower connector, the evaporator is connected with the condenser, and the condenser is connected with the liquid storage tank and the upper connector; and the upper joint and the lower joint are respectively connected to a liquid storage tank. According to the utility model, the mesh enclosure can intercept blood perfusion resin and allows small particles such as scraps, powder and the like to pass through, and impurities and pollutants in a blood perfusion adsorbent can be comprehensively and effectively cleaned in cooperation with reverse ultrasonic extraction and forward ultrasonic extraction; through the combination of the evaporator and the condenser, the recycling and recovery of the cleaning solvent are realized.

The utility model discloses a hemodialysis filter with a blood perfusion adsorption function. The hemodialysis filter comprises a filter, two dialysate connectors, a plurality of hollow fiber filaments, two blood connectors and a plurality of adsorption particles. The two dialysate connectors are fixedly connected with the outer wall of the filter, the inner ends of the two dialysate connectors penetrate through the inner wall of the filter, and the dialysate connectors are used for conveying dialysate; the plurality of hollow fibers are mounted on the inner wall of the filter and are made of polyether sulfone membranes; the two blood interfaces are respectively connected in series with the two ends of the filter; the plurality of adsorption particles are mounted in the hollow fiber filaments which are far away from the blood connector and the dialysate connector and are 1 / 3-1 / 2 of the number of the hollow fiber filaments, and the adsorption particles are resin carbon soaked by heparin. According to the hemodialysis and perfusion combined device, the hemodialysis and perfusion functions can be simultaneously completed by a single device through the combination of the characteristics of the hemodialysis filter and the hemoperfusion device, so that the occurrence of infection of patients is reduced.

This invention provides a pre-flushing method, equipment, and storage medium for a blood purification device. The pre-flushing method includes: closing the connection between the hemoperfusion unit and the dialyzer, opening the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit for pre-flushing; determining a first pre-flushing flow rate of the pre-flushing fluid; if the first pre-flushing flow rate is higher than a first threshold, activating a vacuum pump to extract gas from the waste liquid tank until the pre-flushing of the hemoperfusion unit is confirmed to be complete; opening the connection between the hemoperfusion unit and the dialyzer, closing the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit to pre-flushing the dialyzer until the pre-flushing of the dialyzer is confirmed to be complete. This invention solves the problems of poor pre-flushing effect and low efficiency in existing blood purification devices.

The invention discloses an auxiliary exhaust device for a hemoperfusion device, and relates to the field of auxiliary instruments for blood purification treatment, and the auxiliary exhaust device for the hemoperfusion device is configured on a wall surface bracket or a movable roller bracket. The auxiliary exhaust device of the hemoperfusion device comprises an outer cover plate, a vibration inclination angle mechanism, a hemoperfusion device fixing clamp and an inclination angle flapping mechanism, a plurality of positioning notches are formed in the front side of the outer cover plate, an opening is formed in the middle of the outer cover plate, and guide rails A are arranged on the two sides of the upper end face of the opening; the perfusion device fixing clamp is of an elastic clamping structure, and the perfusion device fixing clamp is installed on the dip angle adjusting assembly in a clamped mode. The dip angle flapping mechanism is arranged in a positioning notch in the front side of the outer cover plate, and the dip angle flapping mechanism and the perfusion device are fixedly clamped on the same vertical center line; according to the auxiliary exhaust device of the hemoperfusion device, through cooperative arrangement of the oscillation dip angle mechanism and the dip angle flapping mechanism, the bubble exhaust efficiency and the operation safety can be comprehensively improved.

This invention discloses a renal hemoperfusion device for use before renal ischemia, relating to the field of perfusion devices. It includes a housing with a pair of fasteners on its side for securing a syringe to each; a movable plate, mounted within the housing via a moving mechanism that drives the movable plate to move within the housing; and a pair of pushers, both mounted on the movable plate, for pushing the piston handle in the syringe. Each pusher includes a sliding sleeve, a moving sleeve, and an elastic member. The sliding sleeve is located on the side of the movable plate, and the moving sleeve is slidably inserted into the sliding sleeve. The advantages of this invention are: strict separation of the two stages avoids human timing errors during operation, ensuring perfusion only after blood vessel closure; the mechanical interlocking mechanism between the baffle and the travel strip forces perfusion to begin only after the fluid-filled bladder has fully expanded, eliminating the risk of misoperation at the hardware level; seamless switching between the injection expansion and perfusion stages ensures high efficiency; and the mechanically pushed perfusion speed during perfusion is more uniform, resulting in better efficacy.

This invention discloses a hemoperfusion support device and a dialysis machine for combined hemoperfusion and hemodialysis, including a mounting base, a right telescopic cylinder I, an L-shaped bracket, a hemoperfusion bracket rotation motor, a dialyzer bracket rotation motor, a hemoperfusion bracket, and a dialyzer bracket. The L-shaped bracket is fixedly connected to the right telescopic cylinder I. The dialyzer bracket rotation motor is fixedly mounted on the top of the L-shaped bracket. The dialyzer bracket is mounted on the power output shaft of the dialyzer bracket rotation motor. The hemoperfusion bracket rotation motor is fixedly mounted on the bottom right end of the L-shaped bracket. This hemoperfusion support device and dialysis machine achieve automatic rotation, tilting, and vibration, thereby achieving automatic air venting and impurity removal from the hemoperfusion device and dialyzer without manual operation. The hemoperfusion device and dialyzer can be pre-flushed, vented, and impurity removed simultaneously, saving time, reducing reliance on medical personnel, and reducing the risk of infection from manual operation when connecting arterial and venous puncture needles.

This invention relates to the field of medical device testing technology, specifically to the application of LC-MS / MS in determining the content of indophenol sulfate and p-cresol sulfate in a hemoperfusion device. The method includes: mixing plasma and acetonitrile, vortexing and centrifuging, collecting the supernatant, eluting the supernatant through a C18 solid-phase extraction column, collecting the eluent, mixing the eluent with water and filtering to obtain the test solution; performing liquid chromatography and mass spectrometry on the test solution, wherein the mobile phase A of the liquid chromatography is a 3-8 mmol / L gradient concentration ammonium acetate solution containing 0.05% ammonium formate by volume, and the mobile phase B is methanol; S3: calculating the concentrations of indophenol sulfate and p-cresol sulfate in the test solution based on the labeled curve. This invention, through dual purification pretreatment and multi-ion-pair threshold matching technology, can effectively remove more than 95% of interfering protein-binding toxoids. The interference peak response value in blank plasma is less than 5% of the target analyte response value, solving the detection error problem caused by interference in traditional methods.

The invention discloses a method for evaluating the adsorption performance of a blood perfusion device to bilirubin. The method comprises the following steps: obtaining a hyperbilirubinemia rabbit model; and performing blood perfusion on the obtained hyperbilirubinemia rabbit model by using a blood perfusion device, calculating the adsorption rate of the blood perfusion device on bilirubin, and evaluating the adsorption performance of the adsorbent. According to the hyperbilirubinemia animal model, a rabbit is selected as a modeling object, the rabbit is subjected to intragastric administration with an induction reagent twice, and the hyperbilirubinemia rabbit model is obtained; the induction reagent is alpha-naphthyl isocyanate; the administration dosage of the induction reagent during the second time of intragastric administration is greater than that of the induction reagent during the first time of intragastric administration. According to the method, the animal model meeting the requirement for evaluating the adsorption performance of the bilirubin of the adsorbent in a perfusion mode can be rapidly established, the modeling method is simple and rapid, the modeling cost is low, the model operability is high, the adsorption performance of the adsorbent evaluated in the perfusion mode is closer to the clinical practical application condition, and the more accurate and objective evaluation effect is achieved.

The invention belongs to the technical field of blood purification, and discloses a protein binding toxoid adsorbent, a preparation method and application. The adsorbent is porous resin with a quaternary ammonium salt structure, and the porous resin is obtained by carrying out suspension polymerization reaction on a styrene monomer and a co-crosslinking agent; the co-crosslinking agent comprises divinyl benzene and methacrylamide ethylene glycol methyl ether. The adsorbent has excellent adsorption performance and blood compatibility, and effectively solves the problem of accumulation of protein binding toxoid in the body of a chronic kidney disease patient. During preparation, firstly, raw materials such as styrene monomers, divinyl benzene, methacrylamide ethylene glycol methyl ether and the like are subjected to suspension polymerization to prepare microspheres, and then tetramethyl diamine is grafted to the surfaces of the microspheres through quaternization reaction. The preparation method is simple in process, mild in reaction condition and high in safety. The adsorbent disclosed by the invention can be applied to the fields of preparation of blood perfusion devices and clinical removal of protein binding toxoid, and has a wide clinical application prospect.

The utility model discloses a pre-filling flow path structure of a blood perfusion dialysis combined system, which comprises a public flow path, a perfusion flow path and a dialysis flow path, a perfusion device is arranged in the perfusion flow path, a dialyzer is arranged in the dialysis flow path, the perfusion flow path is connected with the dialysis flow path in parallel, and the dialyzer is connected with the public flow path in parallel. The perfusion flow path and the dialysis flow path are connected through a series flow path; a first switch valve and a second switch valve are arranged at the two ends of the perfusion device respectively, a third switch valve is arranged on the series connection flow path, and a fourth switch valve is arranged on the preceding stage flow path of the dialyzer. The parallel connection mode is adopted, the perfusion flow path and the dialysis flow path are connected, meanwhile, the series connection flow path is connected between the perfusion flow path and the dialysis flow path, and the connection state of the perfusion pipeline and the dialysis pipeline is adjusted through opening and closing of the first switch valve, the second switch valve, the third switch valve and the fourth switch valve; therefore, switching between series pre-charging and independent pre-charging is achieved, and bubbles are fully eliminated.

The utility model discloses an extracorporeal circulation blood path for hemodialysis and blood perfusion, which belongs to the technical field of medical instruments and comprises an arterial blood path and a venous blood path, and the arterial blood path comprises an aorta tube, a pump tube, an arterial pot inlet tube, an arterial pot outlet tube and an arterial pressure monitoring tube which are arranged along the flowing direction of arterial blood; the venous blood path comprises a venous pot inlet pipe, a venous pot outlet pipe, a hemodialyzer pipe and a venous pressure monitor which are arranged in the flowing direction of venous blood. The hemoperfusion device blood path comprises an artery connecting pipe, a vein connecting pipe, a waste liquid drainage pipe, an arteriovenous circulation pipe and a waste liquid bag connecting pipe. By means of the mode, connection needed by blood perfusion and connection needed by other blood purification modes (such as hemodialysis) are integrated together, medical staff do not need to splice various complex independent pipelines during operation, the operation process is simplified, and the hemodialysis efficiency is improved.

The utility model provides a blood perfusion adsorber, and belongs to the technical field of perfusion devices. The hemoperfusion device solves the problem that an existing hemoperfusion device is poor in sealing reliability due to the fact that end face sealing is adopted. The blood perfusion adsorber comprises a cylindrical shell, a filter screen rack, an end cover and a locking nut are arranged at the two ends of the shell respectively, the filter screen rack is located in the shell and abuts against an inner annular step of the shell, the end cover is located in the shell and pressed on the filter screen rack, the locking nut is pressed on the end cover, and the filter screen rack is located in the shell and abuts against the inner annular step of the shell. A sealing ring is arranged between the outer ring face of the end cover and the inner ring face of the shell, an internal thread is arranged on the locking nut, an external thread is arranged on the shell, and the cross section of the external thread and the cross section of the internal thread are in a right trapezoid shape. The sealing mode is radial sealing, and the extrusion degree of the sealing ring is irrelevant to the pre-tightening force of the threads; the end cover and the locking nut are designed in a split manner, and the required pretightening force is small, so that the sealing reliability is improved; the cross sections of the external threads and the internal threads are right-angled trapezoids, so that the creep resistance of the threads can be improved.

The application belongs to the technical field of biological medicine, and relates to a hemoperfusion adsorbent, a preparation method and application thereof. The hemoperfusion adsorbent is a microsphere structure, the carrier of the microsphere is a chitosan microsphere, the ligand is type I collagen, and the particle size of the microsphere is 250-1000 mu m. The hemoperfusion adsorbent provided in the application has the characteristics of large adsorption amount of bilirubin, high selective adsorption, small adsorption of albumin and the like based on the synergistic effect of collagen and chitosan, has excellent specific adsorption effect of bilirubin, is low in cost, and has good clinical application prospect.

The utility model discloses a multifunctional hemoperfusion device flushing machine, and belongs to the technical field of blood purification. Comprising a clamping tool used for clamping a perfusion device; the upper butt joints and the lower butt joints are used for being in butt joint with the upper end and the lower end of a perfusion device and are communicated with the perfusion device. The upper main pipeline is communicated with the upper butt joint; the upper main pipeline is respectively connected with an upper vacuum valve, an upper air valve, an upper water inlet valve and an upper water outlet valve; the lower main pipeline is communicated with the lower butt joint; and the lower main pipeline is respectively connected with a lower vacuum valve, a lower air valve, a lower water inlet valve and a lower water outlet valve. The upper butt joint and the lower butt joint are connected to the upper main pipeline, pressure maintaining stop valves are installed in pipelines of the lower main pipeline respectively, and the upper butt joint is connected with a pressure sensor. According to the utility model, the clamping cylinder is matched with each control valve, so that the flushing machine integrates the functions of clamping, flushing, leak detection and the like, the operation efficiency and accuracy are greatly improved, and the risk and cost caused by quality problems are reduced.

The invention belongs to the technical field of blood purification, and particularly relates to a strongly acidic cation exchange resin adsorbent, a preparation method and a hemoperfusion device. In the preparation process of the strongly acidic cation exchange resin adsorbent provided by the invention, the technical means such as acetyl protection of hydroxyl, activation treatment of acidic organic solvents such as acetic acid, sulfonation reaction in a stepped temperature increasing mode and the like are adopted; the problem that the original pore structure and adsorption performance of the resin adsorbent are damaged is avoided, the resin adsorbent can modify hydroxyl and sulfonic acid modification groups at the same time, and the adsorption performance and blood compatibility of the resin adsorbent are improved; the dosages of an acetylation reagent, an acidic organic solvent, a sulfonation reagent and an alkaline reagent are limited according to the content of hydroxyl on the surface hydroxylated polystyrene-divinyl benzene resin ball, so that the performance of the resin adsorbent is further improved; therefore, the technical problem that an existing synthetic resin adsorbent is low in adsorption performance and blood compatibility is solved.

The application discloses a kind of main control architecture system and its control method for unified blood processing platform, which includes top-down decision layer, execution layer and perception layer;Through the three-layer decoupling architecture of "decision layer-execution layer-perception layer", it is first realized in the field of blood processing Unified platform control across device types, across physical principles;Second, cross-device unified interface, realize plug and play extension;Third, based on the scheduling mechanism of capability unit, realize device-independent control;In addition, the application supports dynamic updating of strategy, enables intelligent evolution, and the state-strategy mapping library can be realized using a rule engine or a machine learning model, and supports dynamic updating;Finally, through the capability mapping mechanism of device adapter, the same main control system can uniformly manage multiple treatment scenarios such as plasma separation, hemodialysis, hemoperfusion, etc.

This invention relates to the field of medical device technology, specifically to a pre-filling and venting device for a hemoperfusion apparatus. The device includes a mounting base with a horizontally arranged annular slide rail mounted on its upper end; a clamping mechanism mounted above the annular slide rail for clamping and fixing the perfusion apparatus at the center of the annular slide rail; and a venting mechanism including a slide block, a driving assembly, and a striking assembly. The slide block is slidably mounted on the annular slide rail, and both the driving assembly and the striking assembly are mounted on the slide block. The driving assembly drives the slide block to slide along the annular slide rail and simultaneously drives the striking assembly to strike the bottom of the perfusion apparatus to vent air. The driving assembly drives the slide block to move in a circular motion along the annular slide rail, while simultaneously driving the striking assembly to continuously strike the bottom of the perfusion apparatus, causing air bubbles at the bottom to move to the top and be expelled. Furthermore, the striking head can strike the sidewall of the perfusion apparatus, loosening air bubbles in the gaps between the adsorbents through sidewall vibration, further accelerating air bubble expulsion, saving manpower, and improving work efficiency.

This specification provides a structure for in vitro blood perfusion that can effectively remove reactive oxygen species (ROS) that cause inflammation in the blood, an in vitro blood perfusion tube including the structure and an in vitro blood purification device, a method for preparing the structure, and an in vitro blood purification method using the in vitro blood purification device, wherein the structure for in vitro blood perfusion includes cerium dioxide nanoparticles and a carrier loaded with cerium dioxide nanoparticles.

The invention discloses an MOFs-based blood perfusion adsorption material and a preparation method thereof, and relates to the technical field of blood perfusion, the adsorption material takes a melt-blown non-woven fabric as a matrix, in-situ growth of an adsorbent MOFs and heparin connected with an MOFs organic ligand in a covalent bond mode is carried out on the surface of the melt-blown non-woven fabric, the gram weight of the melt-blown non-woven fabric is 30-200g / m < 2 >, and the fiber diameter is 0.3-7.5 [mu] m. The hemolysis rate of the MOFs-based blood perfusion adsorption material is kept within 10%, the MOFs-based blood perfusion adsorption material has good biocompatibility, the selected melt-blown cloth base body has good biocompatibility and high porosity, part of protein binding elements with large particle sizes can be preliminarily screened out, the MOFs-based blood perfusion adsorption material shows excellent adsorption performance for various toxins in blood, and the MOFs-based blood perfusion adsorption material is suitable for being applied to various toxins in blood. The excellent anticoagulation effect is realized.

1. Name of the product in this design: Blood purification equipment. 2. Application of this design: for patients undergoing continuous blood purification therapy, plasma exchange therapy, plasma adsorption therapy, albumin adsorption therapy, hemoperfusion therapy, and extracorporeal carbon dioxide removal therapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other situations requiring explanation: Part A is made of transparent material.

The utility model relates to the technical field of medical instruments, in particular to a hemoperfusion device resin quantitative filling device which comprises a base, the higher top of the base is fixedly connected with a quantitative feeding box, the bottom end of the quantitative feeding box is provided with a pre-storage cavity, the outer wall of one side of the base is fixedly connected with two supporting plates, and the supporting plates are fixedly connected with the base. One end of each supporting plate is fixedly connected with a [-shaped frame, and a vibration assembly is arranged in each [-shaped frame. Through the arranged vibration assembly, the stably-installed hemoperfusion device can be impacted at high frequency, the upper half part and the lower half part of the outer wall of the hemoperfusion device can be knocked, so that the position of filled resin is changed, uniform distribution of the resin is promoted, formation of gaps is reduced, the adsorption effect is improved, quantitative and enough resin particles can fall down every time a partition plate is pulled away, and the adsorption effect is improved. And then the resin falls into the hemoperfusion device, quantitative filling of the resin is completed, that is, formation of gaps can be reduced while quantitative filling is completed, two purposes are achieved at a time, and efficiency is improved.

The utility model discloses an integrated sealing cap and a hemoperfusion device, which comprise a cap cover with an opening on the bottom side; the connecting screw sleeve is connected to the inner top side of the cap; the sealing nozzle is connected to the inner top side of the cap and located in the connecting threaded sleeve, the cap, the connecting threaded sleeve and the sealing nozzle are of an integrally-formed structure, sealing connection can be rapidly and stably achieved, the cap, the connecting threaded sleeve and the sealing nozzle are integrally formed, production is convenient, the production cost can be reduced, and the overall practicability is improved.

This utility model relates to a stabilizing clamping device for dialysis, used to simultaneously clamp a hemodialysis machine and a hemoperfusion device. It includes a first clamping unit, an extension unit, a mounting unit, a first length adjustment unit, a second clamping unit, a second length adjustment unit, and a third clamping unit. Its advantages are: the first clamping unit clamps the device, allowing for flexible selection of the fixing position and improving applicability; the second clamping unit stably clamps the hemodialysis machine, and the third clamping unit stably clamps the hemoperfusion device, with adjustable dimensions according to the specifications of the hemodialysis machine and hemoperfusion device, and also allowing for tubing management; the first length adjustment unit adjusts the position of the second clamping unit, and the second length adjustment unit adjusts the position of the third clamping unit, maintaining the balance of the hemodialysis machine and hemoperfusion device while meeting space requirements.

The application discloses a kind of sulfonated polyether sulfone adsorption microspheres for blood perfusion and preparation method thereof, belong to the technical field of biomedical materials.The microspheres are prepared from polyether sulfone, sulfonated polysulfone, n-hexane, PVP and N,N-dimethylacetamide, and are formed into a structure dominated by 2-50 nm mesopores by using n-hexane and PVP to synergistically form pores, and are modified by grafting polyethylene glycol.The application provides a preparation method, including the steps of blending dissolution, drop ball molding, mild washing and surface grafting modification.The obtained microspheres have a particle size of 1-1.5 mm, and a mechanical breakage rate of less than or equal to 0.5%.The microspheres have extremely high adsorption selectivity and capacity for beta2-microglobulin and interleukin-6, with an adsorption capacity of greater than or equal to 600 μg / g and greater than or equal to 4500 pg / g, respectively, can effectively remove inflammatory factors and medium and large molecular toxins from blood, and the preparation process is stable and suitable for large-scale production.

The utility model discloses a hemoperfusion device, relates to the technical field of blood purification, it includes the cylinder, be provided the inlet end cover and the outlet end cover of cylinder both ends respectively, and heating device, the heating device is used for raising the temperature in the cylinder and maintains at the specified temperature, the utility model provides a hemoperfusion device. When treatment is carried out, the heating device is turned on to heat the interior of the cylinder body and maintain the temperature at the specified temperature, so that the conditions of viscosity increase and fluidity reduction caused by temperature reduction of blood are avoided, the risk of blood coagulation is reduced, meanwhile, the conditions of hypothermia are reduced, and the problems that the viscosity increase of the blood is caused by temperature reduction and the fluidity of the blood is reduced are solved. The problem that the treatment effect is affected due to reduction of the adsorption surface area of resin microspheres caused by mutual adhesion of the resin microspheres after the resin microspheres in the perfusion device are in contact with the blood is solved.

The invention discloses an exhaust device and a blood perfusion device, and relates to the technical field of medical auxiliary instruments.The exhaust device comprises a limiting mechanism and a plurality of hammering mechanisms, a containing cavity is formed in the limiting mechanism and used for containing and fixing a blood perfusion device, and the hammering mechanisms are arranged in the circumferential direction of the limiting mechanism and used for hammering the blood perfusion device. The plurality of hammering mechanisms can extend into the accommodating cavity and knock the peripheral side of the hemoperfusion device at the same time; the blood perfusion device comprises a blood perfusion device and the exhaust device, and the blood perfusion device is placed in the limiting mechanism. According to the mechanical hammering mechanism, manual continuous operation is not needed, the time and physical strength of medical staff are saved, the situation of hand tension is relieved, after the hammering mechanism stretches out of the limiting mechanism, peripheral synchronous knocking can be automatically completed, meanwhile, multiple parts of the hemoperfusion device are knocked, all-directional vibration is formed, and the bubble discharging speed is increased.