141 results about "Hemoperfusion" patented technology

The invention provides a metal organic framework composite adsorbent, a preparation method thereof and a hemoperfusion device, and belongs to the technical field of blood purification adsorption materials. The metal organic framework composite adsorbent provided by the invention is a metal organic framework material-polysulfone material composite sphere, the metal organic framework material has excellent adsorbability to various toxins, and the polysulfone material has good biocompatibility, mechanical strength, processing adaptability and sterilization capability; therefore, the metal organic framework composite adsorbent has good blood compatibility and toxin adsorbability, is less in adsorbent particle falling, and is suitable for the field of whole blood perfusion. The result of the embodiment shows that the metal organic framework composite adsorbent provided by the invention has excellent adsorption performance on p-cresol sulfate, indoleacetic acid, bilirubin, bile acid and endotoxin, and shows excellent blood compatibility.

The invention provides a quadruple plasma blood purification device and purification method. The quadruple plasma blood purification device comprises a primary plasma separator, a secondary plasma separator, a perfusion device and a dialyzer, the inlet of the primary plasma separator is connected with the artery of a patient; an inlet of the secondary plasma separator is connected with the primary plasma separator; an inlet of the perfusion device is connected with the secondary plasma separator; and the dialyzer is respectively connected with the perfusion device and the primary plasma separator. According to the technology, only one-time operation is needed for treatment for 6-12 hours, multiple operations are not needed, meanwhile, the core pathogenesis of hypertriglyceridemia, cytokine storm sepsis, internal environment disorder and renal insufficiency which cause pancreatitis is solved, the treatment time is saved to a great extent, the risk that the illness state develops to death is reduced, and the treatment cost is reduced. The clinical effective treatment rate is improved; in addition, only one set of equipment is needed, and the device has the advantages of low cost, simplicity and convenience in operation, low time, manpower and financial resource consumption, high treatment efficiency and the like.

The invention relates to the field of blood purification, and particularly discloses adsorption resin for blood perfusion and a preparation method of the adsorption resin. The adsorption resin for blood perfusion is prepared from polystyrene, divinylbenzene, dimethylaminoethyl methacrylate, acrylamide, chitosan and a pore-foaming agent. The preparation method comprises the following steps: uniformly stirring polystyrene, divinylbenzene, dimethylaminoethyl methacrylate and acrylamide at normal temperature to form a mixture; adding an initiator and a pore-foaming agent into the mixture, and stirring, wherein the use amount of the initiator is 0.5-1.5% of the total mass of the mixture; heating the mixture to 60-80 DEG C in a nitrogen environment, and reacting for 12-16 hours to obtain adsorption resin; placing adsorption resin in the chitosan solution, heating to 50 DEG C, and reacting for 3 hours; and after the reaction is finished, washing and drying a product to obtain the adsorbent resin for blood perfusion. The adsorbent resin for blood perfusion has the advantages that organic phosphorus is efficiently adsorbed, and blood cell adsorption damage is reduced.

The invention provides an adsorbent with a heparin slow release function, a preparation method of the adsorbent and a hemoperfusion device, and belongs to the technical field of adsorbent resin. The preparation method comprises the following steps: firstly preparing epoxy group-containing cross-linked porous resin, then reacting with an amino acid compound, and carrying out amino acid grafting modification on the surface of the epoxy group-containing cross-linked porous resin by utilizing the reaction between an epoxy group and an amino group, so that the blood compatibility is improved, and the interaction between the adsorbent and blood components is changed; furthermore, the amino acid modified adsorption resin is cross-linked by using an amido-containing micromolecule cross-linking agent, so that on one hand, the cross-linking degree, the pore structure and the surface property of the adsorbent are changed, and the interaction between the adsorbent and heparin is adjusted, and on the other hand, the specific interaction with heparin is increased by introducing an amine group; the adsorbent has the performance of adsorbing heparin and slowly releasing the heparin, the clinical use amount and use frequency of the heparin are reduced, and the clinical treatment safety is improved.

The invention provides an exhaust device of a hemoperfusion device. The exhaust device comprises a mounting plate, an angle conversion mechanism and a vibration mechanism, the angle conversion mechanism comprises a cantilever fixed on the mounting plate, a rotating shaft which is rotatably connected in the cantilever and one end of which extends out of the front end of the cantilever, and a motor which is mounted on the mounting plate and is used for driving the rotating shaft to rotate; the vibration mechanism comprises a batten, a lower base plate, an upper base plate, a lower tray and an upper tray, wherein the middle of the batten is fixedly connected with the front end of the rotating shaft, the lower base plate is fixedly connected to the lower end of the batten, the upper base plate is slidably mounted at the upper end of the batten, the lower tray is mounted above the lower base plate, and the upper tray is mounted below the upper base plate. A plurality of vibrators are mounted between the lower base plate and the lower tray and between the upper base plate and the upper tray, and slotted holes extending to the center are formed in the edges of the same positions of the lower base plate, the lower tray, the upper base plate and the upper tray. According to the device, vibration exhaust can be carried out on the perfusion device at different angles, manpower is saved, and the working efficiency is improved.

The invention discloses an automatic flushing device for a hemoperfusion device, and relates to the technical field of medical instruments. Comprising a base and a flushing structure, a vertical frame is arranged at the top of the base, and a flushing fluid box is arranged on one side of the vertical frame; the vertical frame is further provided with a lifting structure and a lifting table, and the lifting table is installed on the lifting structure. A back plate is arranged at the top of the lifting table; the flushing structure is mounted on the side surface of the back plate; a pump machine is arranged in the flushing fluid tank, a fixing pipe is arranged at the output end of the pump machine, penetrates through the top of the flushing fluid tank and is provided with a connecting port, the connecting port is provided with a flushing fluid feeding pipe, and the other end of the flushing fluid feeding pipe is connected with the flushing structure; the top of the base is further provided with a waste water barrel, and the flushing structure is further provided with a waste liquid collecting pipe. The device is compact and reasonable in overall structure and easy to operate and understand, the workload of medical staff can be remarkably relieved, the medical resource utilization efficiency is improved, and the device has important clinical application value and popularization prospects.

The present application discloses a hemoperfusion device, which includes a cylinder body. A filter element assembly is arranged inside the cylinder body. A flexible blood bag is arranged at the top of the cylinder body. A flexible liquid bag is arranged inside the cylinder body and is internally connected to the filter element assembly. The volume of the flexible liquid bag can change under the action of an external force. A filter membrane assembly internally connected to the filter element assembly is arranged inside the flexible blood bag. An inlet and an outlet are arranged on the flexible blood bag. Two one-way valves arranged in the same direction are respectively arranged on both sides of the filter membrane assembly. A partition is arranged inside the blood bag. A reflux channel is formed between the partition and the filter membrane assembly, and the interior of the blood bag is divided into a first inner cavity and a second inner cavity. After the blood enters the first inner cavity through the inlet, it flows into the cylinder body from one one-way valve. After the blood is filtered by the filter membrane assembly and the filter element assembly, it flows to the second inner cavity from the other one-way valve. Part of the blood flows out through the outlet, and part of the blood can flow back to the first inner cavity through the reflux channel.

The invention relates to an adsorbing material for blood perfusion and a preparation method thereof. The preparation method comprises the following steps: providing a hydrophobic porous carrier which comprises styrene-divinyl benzene copolymer microspheres, and introducing a coordination group on the surface of the hydrophobic porous carrier through chemical modification. The average pore size of the hydrophobic porous carrier is 2-50 nm, and the specific surface area of the hydrophobic porous carrier is greater than or equal to 500 m < 2 > / g; the coordination group is selected from at least one of iminodiacetic acid (IDA), ethylenediaminetetraacetic acid (EDTA) and N, N, N-tricarboxymethyl ethylenediamine (TED). The prepared adsorption material is high in A beta removal capacity, has certain removal capacity on heavy metal ions, is good in blood compatibility and excellent in anticoagulation performance, and is an ideal material for preparing a blood perfusion device.

The present invention relates to a mucin-containing blood perfusion composition, a blood perfusion device and applications thereof. The blood perfusion composition comprises a mucin component, poloxamer and a resin. The blood perfusion device adopts the above-mentioned perfusion composition, which can effectively reduce free radicals in the patient's body, so that the free radical level is controlled at a low level, and effectively improves the blood condition of stroke patients.

The invention discloses a blood perfusion adsorbent for adsorbing endotoxin by double acting forces as well as a preparation method and application of the blood perfusion adsorbent. The adsorbent (PS-DVB (at) p (CD-His)) is subjected to raft polymerization through 4-cyano-4-(thiobenzoic acid) valeric acid grafted on the surface of PS-DVB to generate a glycidyl methacrylate brush polymer, and is combined with an L-histidine modified cyclodextrin functional molecule; the positive charges of histidine groups and the hydrophobic cavities of the cyclodextrin are used for realizing electrostatic and hydrophobic interaction to synergistically and efficiently adsorb endotoxin. The materials of the blood perfusion adsorbent are easy to obtain, the cost is low, the blood perfusion adsorbent has good blood compatibility and endotoxin adsorption performance, the development of the adsorbent is beneficial to in-vitro blood perfusion treatment of septicopyemia patients, and the clinical treatment cost is reduced.

The present invention discloses a method for preparing a filler for a blood perfusion device by double biomineralization, the method comprising: (1) primary biomineralization: preparing a mixed solution A containing sodium alginate, water-soluble phosphate, purification factor and magnetic particles, and a solution B containing chitosan and calcium chloride, then dripping the mixed solution A into the solution B to obtain biomineralized magnetic capsule particles; (2) secondary biomineralization: preparing a silica precursor solution and an acidic buffer solution containing glycerol, then mixing the biomineralized magnetic capsule particles, the silica precursor solution and the acidic buffer solution, then adding polyallylamine, and reacting to obtain the filler for the blood perfusion device. Compared with the existing macroporous resin and activated carbon for blood perfusion devices, the present invention utilizes biomineralization to physically embed the purification factor in the filler, and during embedding, the corresponding purification factor can be flexibly selected according to different pathogenic factors, and the prepared filler has good biocompatibility.

The invention relates to the field of medical instruments, and particularly discloses a magnetic composite adsorbent for blood perfusion as well as a preparation method and application of the magnetic composite adsorbent. According to the magnetic composite adsorbent, magnetic nanoparticles serve as an inner core and are connected with endotoxin affinity peptide through a cross-linking agent, and the composite adsorbent is formed; the amino acid sequence of the endotoxin affinity peptide is as follows: Lys-His-Arg-Asp-Cys-Lys-Trp-Leu-Lys-Arg-Cys-Trp, and the amino acid sequence of the endotoxin affinity peptide is as follows: Lys-His-Arg-Asp- The magnetic composite adsorbent has specific affinity to endotoxin, and the endotoxin affinity peptide is fixed on the surface of the magnetic nanoparticle through a chemical bond, so that the adsorbent is easy to recover through magnetic separation in the blood perfusion process, and the endotoxin affinity peptide is not easy to fall off and remain in blood; therefore, the method is safer and more efficient.

The invention discloses a protein / polysaccharide composite dialysis membrane based on in-situ loaded lanthanum carbonate and application of the protein / polysaccharide composite dialysis membrane, a lanthanum carbonate loaded protein / polysaccharide composite aggregate is used for modifying a porous filter membrane, and the dialysis membrane with a lanthanum carbonate loaded protein / polysaccharide self-assembled membrane as a compact skin layer and the porous filter membrane as a supporting layer is formed. By integrating a membrane separation mechanism of hemodialysis and an adsorption principle of blood perfusion, the skin layer of the dialysis membrane has molecular sieve separation and chemical adsorption functions, efficient removal of molecular uremic toxins (phosphorus, creatine liver, bilirubin, p-cresol sulfate and indol sulfate) with different sizes is synergistically realized, macromolecular proteins in blood are effectively intercepted by pore size screening, and the dialysis membrane has the advantages of simple structure, low cost and high efficiency. According to the present invention, by using the adsorption effect of the functional group on the surface of the membrane, the high removal rate on the protein-bound urotoxin is achieved, the high removal effect on phosphorus is particularly achieved, the blood compatibility is considered, the large-scale preparation is easily achieved, and the new idea is provided for the development of the high-performance blood purification material.

The utility model relates to the technical field of medical instruments, and discloses hemoperfusion device flushing equipment which comprises a plurality of sets of main body assemblies. Each group of main body assembly comprises a grab handle of which the two ends are fixedly connected with mounting plates; the drainage pipe penetrates through the lower mounting plate; the water inlet pipe penetrates through the upper mounting plate; the hemoperfusion device flushing equipment has the advantage of being high in flushing efficiency, the hemoperfusion device is clamped between the two connecting sleeves through the mounting mechanism, then water is introduced into the hemoperfusion device from the water inlet pipe, the motor is started to drive the rotating disc to rotate, the rotating disc rotates to drive the connecting column to rotate at the same time, and the hemoperfusion device is flushed through the connecting column. The connecting column drives the connecting rod to move and rotate, the connecting rod moves to drive the sliding rod to move back and forth in a reciprocating mode, then the sliding rod drives the baffle to swing, the baffle swings to guide water flow to flush the inner wall of the hemoperfusion device, a large amount of water is flushed to the inner wall of the hemoperfusion device, and the problem that flushing efficiency is low is solved.

The present invention discloses a batch pre-flushing device for a hemoperfusion cartridge and a method for using the same. The device includes: a plurality of hemoperfusion cartridges, and the input end and the output end of each hemoperfusion cartridge can be respectively inserted into a shunt plate and a confluence plate through connecting tubes. The shunt plate is connected to a liquid end through a first pre-flushing liquid tube, and the confluence plate is connected to a waste liquid collector through a second pre-flushing liquid tube. The batch pre-flushing device for a hemoperfusion cartridge provided by the present invention can complete the pre-flushing function for one or more hemoperfusion cartridges as needed, reducing the use of nursing manpower and medical resources.

The invention relates to the technical field of medical instrument inspection, in particular to a method for determining leached substances in a disposable hemoperfusion device, which establishes gas chromatography-mass spectrometry exclusive detection conditions for the leached substances such as styrene, divinylbenzene and naphthalene to realize precise determination of the leached substances. The leached substances in the determination method comprise styrene, divinylbenzene and naphthalene, according to the determination method provided by the invention, the leached substances such as styrene, divinylbenzene and naphthalene can be precisely determined through one-time detection by determining exclusive detection conditions, the detection limit can reach 1.02-2.38 ng / mL, and the detection precision is effectively improved while the detection efficiency is improved.

The invention relates to a preparation method of an MOFs / copolymer composite material. The preparation method comprises the following steps: (1) mixing styrene, divinylbenzene, acrylic acid, a pore-forming agent and an initiator to obtain an oil phase; a dispersant and water are mixed as a water phase; (2) injecting the oil phase into the water phase to carry out copolymerization reaction, and after the reaction is finished, cleaning to remove the pore-foaming agent to obtain a PS-DVB-AA precursor; (3) adding the PS-DVB-AA precursor into a zinc-containing aqueous solution for a chelating reaction, adding a 2-methylimidazole aqueous solution after the reaction is finished, and filtering to obtain compound particles; and (4) after the reaction is completed, washing and drying the obtained compound microparticles for multiple times to obtain the MOFs / copolymer composite material. When the composite material is applied to a blood perfusion adsorbent, not only is the toxin adsorption capacity of the adsorbent material improved, but also the stability of the adsorbent material is improved.

1. The name of the design product: blood perfusion device. 2. The use of the design product: for blood purification treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to a portable automatic blood purification system, and belongs to the technical field of blood purification medical equipment. The system comprises an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube and a blood outlet tube. The artificial kidney unit comprises a first peristaltic pump, a second peristaltic pump, a first dialyzer, a fourth peristaltic pump, an anticoagulant container and an injection pump; the artificial liver unit comprises a second dialyzer, a hemoperfusion device, an albumin storage container and a third peristaltic pump; the device is characterized by further comprising an artificial lung unit composed of an oxygen container, and the oxygen container is connected between the second outlet of the second compartment of the first dialyzer and the inlet of the second peristaltic pump in parallel through two switches. The device is provided with an emergency life maintenance function device combining the artificial kidney, the artificial liver and the artificial lung, the artificial lung unit is additionally arranged, and when a patient is in a coma condition, timely treatment is achieved by conveying oxygen. The invention is suitable for war, serious injury, burn, poisonous snake and insect bites, pesticide poisoning and other occasions.

The invention relates to the technical field of blood purification, and particularly discloses an adsorbent for removing myoglobin in blood and a preparation method of the adsorbent. The adsorbent for removing the myoglobin in the blood is prepared by grafting double bonds, imprinting and crosslinking, eluting template molecules, imprinting and then modifying, the prepared adsorbent can specifically adsorb the myoglobin and can be repeatedly used for more than 5 times through desorption, the adsorption rate of the myoglobin can still reach more than 80%, and the adsorbent can be used for removing the myoglobin in the blood. Repeated recycling of the material is achieved, and the material can be used for treating hypermyohemoglobin through blood perfusion or plasma adsorption.

The utility model discloses a medical-grade purification treatment device for a blood perfusion adsorbent, and belongs to the technical field of blood purification. A closed mesh enclosure for containing an adsorbent is arranged in an inner cavity of the extraction column; an upper joint and a lower joint which are communicated to the inner cavity as well as a feeding pipe and a discharging pipe which are communicated to the mesh enclosure are mounted on the extraction column; the liquid storage tank is used for containing a purification solvent; the liquid storage tank is connected with the circulating pump, the circulating pump is connected with the filter, the filter is connected with the evaporator, the upper connector and the lower connector, the evaporator is connected with the condenser, and the condenser is connected with the liquid storage tank and the upper connector; and the upper joint and the lower joint are respectively connected to a liquid storage tank. According to the utility model, the mesh enclosure can intercept blood perfusion resin and allows small particles such as scraps, powder and the like to pass through, and impurities and pollutants in a blood perfusion adsorbent can be comprehensively and effectively cleaned in cooperation with reverse ultrasonic extraction and forward ultrasonic extraction; through the combination of the evaporator and the condenser, the recycling and recovery of the cleaning solvent are realized.

The invention relates to the technical field of nuclear medicine, in particular to application of an ammonium phosphomolybdate polyacrylic resin material, ammonium phosphomolybdate polyacrylic resin is obtained by cross-linking ammonium phosphomolybdate, polyacrylic acid microspheres and N, N-methylene bisacrylamide, blood is led out of a body for adsorption through a blood perfusion technology, and the adsorption capacity of the ammonium phosphomolybdate polyacrylic resin material is improved. According to the present invention, the in-vivo radionuclide decontamination effect is achieved, the material has good biocompatibility, the discharge promoting agent is prevented from entering the body and the adverse reaction caused by the discharge promoting agent is avoided so as to improve the treatment success rate of the nuclear exposure wounded, and the problem that the Cs in the dialysate needs to be secondarily removed is solved compared with the common hemodialysis; in this way, the technical problems that in the prior art, a used discharge promoting agent has renal toxicity in the using process, adverse reactions such as lack of trace elements in the human body are caused, the discharge promoting effect is limited, and waste liquid treatment is conducted after pure hemodialysis are solved.

The invention provides a multifunctional hemoperfusion device flushing machine, and belongs to the technical field of flushing machines, the multifunctional hemoperfusion device flushing machine comprises a rack, a cleaning table, a clamping assembly, a base and a hemoperfusion device, the rack is provided with a plurality of first telescopic cylinders and a plurality of second telescopic cylinders, and the first telescopic cylinders and the second telescopic cylinders are in one-to-one correspondence; the first telescopic air cylinders are connected with upper flow guide assemblies, piston rods of the second telescopic air cylinders are connected with lower flow guide rods, lower flow guide caps are installed on the lower flow guide rods, first flow guide grooves and second flow guide grooves are formed in the lower flow guide caps, and pressing blocks are installed on the lower flow guide caps in a sleeving mode through elastic pieces. By changing the flushing direction of water flow, cleaning of dead corners of the inner wall of the port of the perfusion device can be completed, and the cleaning quality is improved.

The utility model relates to a disposable cellulose gel microsphere hemoperfusion device which comprises a middle cylinder, two ends of the middle cylinder are completely opened and are fixed by ultrasonic welding, a gland for completely sealing two ends of the middle cylinder is arranged, a shaft hole is formed in the center of the gland, tightening threads are arranged in the shaft hole, and a double-wing cap is screwed in the shaft hole. A sealing ring is arranged at the end, facing the middle cylinder, of the double-wing cap, a frame type net is fixedly installed on the side, close to the middle cylinder, of the gland, the frame type net, the gland and the middle cylinder are welded and fixed, a connector integrally formed with the middle cylinder is arranged in the middle of the outer side of the middle cylinder, the connector is communicated with the interior of the middle cylinder, a sealing plug is inserted into the connector, and a protrusion is arranged on the outer side of the connector. A sealing plug protection cover is arranged on the connector in a clamped mode, the sealing plug protection cover is used for pressing the sealing plug into the connector, the connector which is formed in the middle of the outer side of the middle cylinder and integrally formed with the middle cylinder can enable materials to be better filled into the middle cylinder, and efficient filling is achieved.

The invention belongs to the field of medical treatment, and particularly relates to a preparation method of a blood perfusion diagnosis and treatment device based on guanosine supramolecular gel, which comprises the following steps: preparing guanosine-boric acid supramolecular hydrogel combined with TMPyP, the guanosine-boric acid supramolecular hydrogel being GB hydrogel; the GB hydrogel combined with the TMPyP probe is attached to the surface of the U-shaped optical fiber; the optical fiber attached with the GB hydrogel is immersed in a lead ion solution for adsorption, meanwhile, the adsorption amount is monitored through electrical and optical bimodal signals, after adsorption is completed, adsorbed lead ions can be replaced for regeneration, and cyclic adsorption is achieved. The adsorption material for blood perfusion, which has high selectivity, excellent blood compatibility, reproducibility and fluid shearing resistance, is integrated with an optical fiber detection device, so that the integration of treatment and monitoring is realized; the GB hydrogel realizes selective adsorption and real-time monitoring of heavy metal ions through a G4 tetramer structure unit.

The present invention provides an airtightness detection device for a blood perfusion device, belonging to the technical field of airtightness detection for blood perfusion devices. The airtightness detection device for a blood perfusion device comprises an inflation assembly, comprising a fixing base and an inflation plug. A side of the fixing base near the detection assembly defines an inflation jack with an axis extending in a front-to-rear direction thereof. A inflation passage extending through the fixing base is defined at the top center of the inflation jack. The inflation plug is sleeved within the inflation jack and is coaxial with the inflation jack. A communicating hole coaxial with the inflation plug and extending through the inflation plug is defined at one end. A circular magnet is fixedly mounted on the end of the inflation plug away from the detection assembly. A connecting hole communicating with the inflation passage is defined at the top center of the communicating hole. A sealing plug is slidably sleeved on the side of the communicating hole near the circular magnet. The end of the sealing plug near the circular magnet is a permanent magnet, and the two sides near each other have the same magnetic properties. This device can operate stably and for a long time in a high-pressure environment.

The present application relates to the field of biomass energy industry equipment, and in particular to a coating device for blood perfusion adsorbent, which includes a shell, a coating mechanism and a drying mechanism arranged in the shell, wherein a coating cavity is formed in the shell, and a coating nozzle for driving adsorbent particles to at least suspend is arranged at the bottom of the coating cavity; the coating mechanism includes a coating tube, a plurality of humidifying nozzles arranged circumferentially on the inner wall of the coating tube, and a conveying assembly for conveying adsorbent particles into the coating tube, wherein the coating tube is vertically fixedly connected to the bottom of the coating cavity, the humidifying nozzle is used to convey atomized coating liquid toward the center of the coating tube, and the conveying assembly is arranged on the lower side of the humidifying nozzle and drives the adsorbent particles from the coating tube into the coating cavity; the drying mechanism is arranged in the shell and used to dry the adsorbent particles output from the coating cavity. The present application can reduce the occurrence of adhesion while forming a uniform and dense coating on the surface of the adsorbent particles.

This invention discloses a method for preparing filler particles for targeted adsorption of low-density lipoprotein (LDL) in patients with atherosclerosis. The steps include: 1) washing D101 macroporous resin with ultrapure water and physiological saline; 2) adding fibrin and PBS solution for soaking; adding thrombin factor II; adding zinc gluconate during the reaction; 3) repeating step 2) at least three times and drying the D101 macroporous resin; 4) adding physiological saline and D101 macroporous resin to lyophilized protein ApoB100 and mixing thoroughly; 5) lyophilizing the resin obtained in step 4) while controlling the humidity at 65±5% to obtain the finished product. This application utilizes this adhesion effect to target the adsorption of foam cells in atherosclerosis, adsorbing foam cells through hemoperfusion, removing redundant blood lipid components in the body, reducing macrophage infiltration of organs and blood vessels, and reducing pathological changes in organs and blood vessels.

The utility model discloses a hemoperfusion device end cover with good anti-slip performance, which relates to the technical field of hemoperfusion devices and comprises an end cover main body shell, one side of the end cover main body shell is fixedly connected with a connecting block, one side of the connecting block is fixedly connected with a connecting plate, and one side of the connecting plate is fixedly connected with a connecting hinge. According to the blood perfusion device, through the arrangement of the lantern ring and the arrangement of the rubber sealing ring, after a user sleeves the lantern ring on the blood perfusion device, the user can install the end cover, and through the arrangement of the upper cover plate and the grip, the user can conveniently use and operate the end cover; through the arranged upper cover plate and the clamping blocks fixedly connected to the side surface of the upper cover plate, after a user rotates the upper cover plate, the user can rotate the clamping blocks to the clamping openings, then the user can take down the upper cover plate through the arranged grip, and therefore the user can conveniently use and disassemble the end cover.

The present specification discloses an extracorporeal blood purification device and an extracorporeal blood purification method using the same. In one aspect, active oxygen (ROS) in blood can be effectively removed in vitro through the porous microbeads loaded with cerium dioxide nanoparticles, and the active oxygen is a substance causing inflammation. Specifically, in order to be able to load the porous microbeads in a blood perfusion cartridge for perfusion to the blood of a patient, an extracorporeal blood purification device is prepared, which is able to widely and quickly remove active oxygen under aqueous solution and blood conditions. Therefore, the method can be applied to an in-vitro blood perfusion treatment system based on the microbeads.