63 results about "Hemoperfusion" patented technology

The invention discloses an automatic flushing device for a hemoperfusion device, and relates to the technical field of medical instruments. Comprising a base and a flushing structure, a vertical frame is arranged at the top of the base, and a flushing fluid box is arranged on one side of the vertical frame; the vertical frame is further provided with a lifting structure and a lifting table, and the lifting table is installed on the lifting structure. A back plate is arranged at the top of the lifting table; the flushing structure is mounted on the side surface of the back plate; a pump machine is arranged in the flushing fluid tank, a fixing pipe is arranged at the output end of the pump machine, penetrates through the top of the flushing fluid tank and is provided with a connecting port, the connecting port is provided with a flushing fluid feeding pipe, and the other end of the flushing fluid feeding pipe is connected with the flushing structure; the top of the base is further provided with a waste water barrel, and the flushing structure is further provided with a waste liquid collecting pipe. The device is compact and reasonable in overall structure and easy to operate and understand, the workload of medical staff can be remarkably relieved, the medical resource utilization efficiency is improved, and the device has important clinical application value and popularization prospects.

The invention discloses a blood perfusion adsorbent for adsorbing endotoxin by double acting forces as well as a preparation method and application of the blood perfusion adsorbent. The adsorbent (PS-DVB (at) p (CD-His)) is subjected to raft polymerization through 4-cyano-4-(thiobenzoic acid) valeric acid grafted on the surface of PS-DVB to generate a glycidyl methacrylate brush polymer, and is combined with an L-histidine modified cyclodextrin functional molecule; the positive charges of histidine groups and the hydrophobic cavities of the cyclodextrin are used for realizing electrostatic and hydrophobic interaction to synergistically and efficiently adsorb endotoxin. The materials of the blood perfusion adsorbent are easy to obtain, the cost is low, the blood perfusion adsorbent has good blood compatibility and endotoxin adsorption performance, the development of the adsorbent is beneficial to in-vitro blood perfusion treatment of septicopyemia patients, and the clinical treatment cost is reduced.

1. The name of the design product: blood perfusion device. 2. The use of the design product: for blood purification treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model discloses a medical-grade purification treatment device for a blood perfusion adsorbent, and belongs to the technical field of blood purification. A closed mesh enclosure for containing an adsorbent is arranged in an inner cavity of the extraction column; an upper joint and a lower joint which are communicated to the inner cavity as well as a feeding pipe and a discharging pipe which are communicated to the mesh enclosure are mounted on the extraction column; the liquid storage tank is used for containing a purification solvent; the liquid storage tank is connected with the circulating pump, the circulating pump is connected with the filter, the filter is connected with the evaporator, the upper connector and the lower connector, the evaporator is connected with the condenser, and the condenser is connected with the liquid storage tank and the upper connector; and the upper joint and the lower joint are respectively connected to a liquid storage tank. According to the utility model, the mesh enclosure can intercept blood perfusion resin and allows small particles such as scraps, powder and the like to pass through, and impurities and pollutants in a blood perfusion adsorbent can be comprehensively and effectively cleaned in cooperation with reverse ultrasonic extraction and forward ultrasonic extraction; through the combination of the evaporator and the condenser, the recycling and recovery of the cleaning solvent are realized.

The utility model relates to a disposable cellulose gel microsphere hemoperfusion device which comprises a middle cylinder, two ends of the middle cylinder are completely opened and are fixed by ultrasonic welding, a gland for completely sealing two ends of the middle cylinder is arranged, a shaft hole is formed in the center of the gland, tightening threads are arranged in the shaft hole, and a double-wing cap is screwed in the shaft hole. A sealing ring is arranged at the end, facing the middle cylinder, of the double-wing cap, a frame type net is fixedly installed on the side, close to the middle cylinder, of the gland, the frame type net, the gland and the middle cylinder are welded and fixed, a connector integrally formed with the middle cylinder is arranged in the middle of the outer side of the middle cylinder, the connector is communicated with the interior of the middle cylinder, a sealing plug is inserted into the connector, and a protrusion is arranged on the outer side of the connector. A sealing plug protection cover is arranged on the connector in a clamped mode, the sealing plug protection cover is used for pressing the sealing plug into the connector, the connector which is formed in the middle of the outer side of the middle cylinder and integrally formed with the middle cylinder can enable materials to be better filled into the middle cylinder, and efficient filling is achieved.

This invention discloses a method for preparing filler particles for targeted adsorption of low-density lipoprotein (LDL) in patients with atherosclerosis. The steps include: 1) washing D101 macroporous resin with ultrapure water and physiological saline; 2) adding fibrin and PBS solution for soaking; adding thrombin factor II; adding zinc gluconate during the reaction; 3) repeating step 2) at least three times and drying the D101 macroporous resin; 4) adding physiological saline and D101 macroporous resin to lyophilized protein ApoB100 and mixing thoroughly; 5) lyophilizing the resin obtained in step 4) while controlling the humidity at 65±5% to obtain the finished product. This application utilizes this adhesion effect to target the adsorption of foam cells in atherosclerosis, adsorbing foam cells through hemoperfusion, removing redundant blood lipid components in the body, reducing macrophage infiltration of organs and blood vessels, and reducing pathological changes in organs and blood vessels.

The utility model discloses a hemoperfusion device end cover with good anti-slip performance, which relates to the technical field of hemoperfusion devices and comprises an end cover main body shell, one side of the end cover main body shell is fixedly connected with a connecting block, one side of the connecting block is fixedly connected with a connecting plate, and one side of the connecting plate is fixedly connected with a connecting hinge. According to the blood perfusion device, through the arrangement of the lantern ring and the arrangement of the rubber sealing ring, after a user sleeves the lantern ring on the blood perfusion device, the user can install the end cover, and through the arrangement of the upper cover plate and the grip, the user can conveniently use and operate the end cover; through the arranged upper cover plate and the clamping blocks fixedly connected to the side surface of the upper cover plate, after a user rotates the upper cover plate, the user can rotate the clamping blocks to the clamping openings, then the user can take down the upper cover plate through the arranged grip, and therefore the user can conveniently use and disassemble the end cover.

The invention relates to a hemoperfusion device and a controller for measuring a blood coagulation state, the hemoperfusion device is connected between an artery side blood loop and a vein side blood loop, and the hemoperfusion device comprises an adsorption column, the adsorption column is provided with at least two adsorption areas which are oppositely arranged and allow to-be-purified blood to be in contact with the adsorbent, and an observation area which is formed between the at least two adsorption areas and allows the to-be-purified blood to independently flow; wherein the at least two adsorption areas are arranged at intervals through a fiber membrane or a baffle structure with filter holes, so that an observation area which is not filled or not completely filled with adsorbent particles is formed between the at least two adsorption areas. The current blood coagulation state progress degree of the hemoperfusion device can be determined according to the blood flowing information of the to-be-purified blood in the observation area, and the working states of the blood pumping device, the anticoagulant pumping device and / or the heating device in the blood purification loop can be selectively adjusted according to the current blood coagulation state.

The utility model discloses a hemodialysis filter with a blood perfusion adsorption function. The hemodialysis filter comprises a filter, two dialysate connectors, a plurality of hollow fiber filaments, two blood connectors and a plurality of adsorption particles. The two dialysate connectors are fixedly connected with the outer wall of the filter, the inner ends of the two dialysate connectors penetrate through the inner wall of the filter, and the dialysate connectors are used for conveying dialysate; the plurality of hollow fibers are mounted on the inner wall of the filter and are made of polyether sulfone membranes; the two blood interfaces are respectively connected in series with the two ends of the filter; the plurality of adsorption particles are mounted in the hollow fiber filaments which are far away from the blood connector and the dialysate connector and are 1 / 3-1 / 2 of the number of the hollow fiber filaments, and the adsorption particles are resin carbon soaked by heparin. According to the hemodialysis and perfusion combined device, the hemodialysis and perfusion functions can be simultaneously completed by a single device through the combination of the characteristics of the hemodialysis filter and the hemoperfusion device, so that the occurrence of infection of patients is reduced.

This invention provides a pre-flushing method, equipment, and storage medium for a blood purification device. The pre-flushing method includes: closing the connection between the hemoperfusion unit and the dialyzer, opening the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit for pre-flushing; determining a first pre-flushing flow rate of the pre-flushing fluid; if the first pre-flushing flow rate is higher than a first threshold, activating a vacuum pump to extract gas from the waste liquid tank until the pre-flushing of the hemoperfusion unit is confirmed to be complete; opening the connection between the hemoperfusion unit and the dialyzer, closing the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit to pre-flushing the dialyzer until the pre-flushing of the dialyzer is confirmed to be complete. This invention solves the problems of poor pre-flushing effect and low efficiency in existing blood purification devices.

The invention relates to the technical field of blood perfusion adsorbents, in particular to an MOF-based adsorbent, a preparation method thereof and application of the MOF-based adsorbent in blood perfusion. The preparation method comprises the following steps: adding MIL-101 (Fe)-NHH spherical particles into a polar solvent to prepare an MIL-101 (Fe)-NHH suspension; the preparation method comprises the following steps: respectively weighing carboxyl terminal short-chain polyethylene glycol, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide, and adding into N, N-dimethylformamide to prepare a PEG-NHS (Polyethylene Glycol-N-Hydroxysuccinimide) active ester solution; the preparation method comprises the following steps: dropwise adding a PEG-NHS active ester solution into an MIL-101 (Fe)-NHS suspension under a stirring condition, reacting the obtained mixed solution at 60-120 DEG C for 6-24 hours under the protection of inert gas, cooling the obtained reaction solution to room temperature, centrifuging to obtain a precipitate, and sequentially washing, carrying out ultrasonic treatment and drying to obtain the MOF-based adsorbent. The MOF-based adsorbent prepared by the invention is an efficient bilirubin adsorbent with high specific surface area, adjustable aperture environment, good blood compatibility and green and safe preparation process.

The invention discloses an auxiliary exhaust device for a hemoperfusion device, and relates to the field of auxiliary instruments for blood purification treatment, and the auxiliary exhaust device for the hemoperfusion device is configured on a wall surface bracket or a movable roller bracket. The auxiliary exhaust device of the hemoperfusion device comprises an outer cover plate, a vibration inclination angle mechanism, a hemoperfusion device fixing clamp and an inclination angle flapping mechanism, a plurality of positioning notches are formed in the front side of the outer cover plate, an opening is formed in the middle of the outer cover plate, and guide rails A are arranged on the two sides of the upper end face of the opening; the perfusion device fixing clamp is of an elastic clamping structure, and the perfusion device fixing clamp is installed on the dip angle adjusting assembly in a clamped mode. The dip angle flapping mechanism is arranged in a positioning notch in the front side of the outer cover plate, and the dip angle flapping mechanism and the perfusion device are fixedly clamped on the same vertical center line; according to the auxiliary exhaust device of the hemoperfusion device, through cooperative arrangement of the oscillation dip angle mechanism and the dip angle flapping mechanism, the bubble exhaust efficiency and the operation safety can be comprehensively improved.

This invention discloses a renal hemoperfusion device for use before renal ischemia, relating to the field of perfusion devices. It includes a housing with a pair of fasteners on its side for securing a syringe to each; a movable plate, mounted within the housing via a moving mechanism that drives the movable plate to move within the housing; and a pair of pushers, both mounted on the movable plate, for pushing the piston handle in the syringe. Each pusher includes a sliding sleeve, a moving sleeve, and an elastic member. The sliding sleeve is located on the side of the movable plate, and the moving sleeve is slidably inserted into the sliding sleeve. The advantages of this invention are: strict separation of the two stages avoids human timing errors during operation, ensuring perfusion only after blood vessel closure; the mechanical interlocking mechanism between the baffle and the travel strip forces perfusion to begin only after the fluid-filled bladder has fully expanded, eliminating the risk of misoperation at the hardware level; seamless switching between the injection expansion and perfusion stages ensures high efficiency; and the mechanically pushed perfusion speed during perfusion is more uniform, resulting in better efficacy.

The invention provides a blood purification loop system which comprises a membrane separator and a hemoperfusion device, the input end of the membrane separator is connected with an artery end, the first output end of the membrane separator is detachably connected with a vein end through a first multi-way pipe, and the second output end of the membrane separator is detachably connected with a waste liquid bag through a second multi-way pipe; the input end of the hemoperfusion device is in disconnectable connection with the first output ends of the first multi-way tube, the third multi-way tube and the fourth multi-way tube or the second end of the second multi-way tube; the output end of the hemoperfusion device is in disconnectable connection with the vein end or the second end of the second multi-way tube; the input end of the fourth multi-way pipe is in disconnectable connection with the output end of the first liquid supplementing source, and the second output end of the fourth multi-way pipe is in parallel connection with the second liquid supplementing source and is in disconnectable connection with the input end of the third multi-way pipe; and the second output end of the third multi-way tube is in disconnectable connection with the vein end. The blood purification efficiency is improved, and potential safety risks in the blood purification process are reduced.

The utility model relates to the technical field of hemoperfusion devices, and discloses a hemoperfusion device gland with a good sealing effect, which comprises a gland body, the outer wall of the gland body is fixedly connected with an anti-skidding raised line, the bottom of the gland body is fixedly connected with a fastening belt, the outer wall of the fastening belt is fixedly connected with a tensioning belt, and the outer wall of the tensioning belt is fixedly connected with an anti-skidding raised line. A fixing piece is fixedly connected to one end of the tensioning belt, a fixing groove is formed in the front face of the fixing piece, a fixing hook is fixedly connected to the front face of the tensioning belt, a clamping groove is formed in the inner top wall of the cover body, a sealing gasket is fixedly connected to the inner wall of the clamping groove, and a blood nozzle is arranged at the top of the cover body. According to the hemoperfusion device gland with the good sealing effect, the joint of the gland body and a hemoperfusion device can be sealed, the outer wall of the fastening belt can be fixed through the use of the tensioning belt, the fastening belt can be tightly hooped on the hemoperfusion device through the connecting use of the fixing piece and the fixing hook, and the sealing effect is improved.

The application provides a blood perfusion adsorbent with low protein adsorption, a preparation method thereof and a blood perfusion device, and belongs to the technical field of blood purification adsorbents. The application introduces vinyl silicone oil into the adsorbent, the vinyl silicone oil has low surface energy, excellent anti-protein adsorption performance and tissue and blood compatibility, and the surface of the cross-linked silicone oil modified adsorption resin prepared through suspension polymerization has a pore structure, so that the adsorbent has good blood compatibility, medium and large molecule toxin adsorption performance and anti-protein adsorption performance. The cross-linked silicone oil modified adsorption resin is further subjected to cross-linking reaction to obtain an ultra-high cross-linked silicone oil modified adsorption resin, and the ultra-high cross-linked silicone oil modified adsorption resin still has anti-protein adsorption performance.

This invention discloses a hemoperfusion support device and a dialysis machine for combined hemoperfusion and hemodialysis, including a mounting base, a right telescopic cylinder I, an L-shaped bracket, a hemoperfusion bracket rotation motor, a dialyzer bracket rotation motor, a hemoperfusion bracket, and a dialyzer bracket. The L-shaped bracket is fixedly connected to the right telescopic cylinder I. The dialyzer bracket rotation motor is fixedly mounted on the top of the L-shaped bracket. The dialyzer bracket is mounted on the power output shaft of the dialyzer bracket rotation motor. The hemoperfusion bracket rotation motor is fixedly mounted on the bottom right end of the L-shaped bracket. This hemoperfusion support device and dialysis machine achieve automatic rotation, tilting, and vibration, thereby achieving automatic air venting and impurity removal from the hemoperfusion device and dialyzer without manual operation. The hemoperfusion device and dialyzer can be pre-flushed, vented, and impurity removed simultaneously, saving time, reducing reliance on medical personnel, and reducing the risk of infection from manual operation when connecting arterial and venous puncture needles.

1. Name of the design product: packing box (star point type of blood perfusion device). 2. Use of the design product: used for containing disposable blood perfusion device. 3. Design points of the design product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The invention relates to the technical field of ascites concentration and reinfusion, in particular to an ascites concentration and reinfusion system which is characterized in that a soft pigtail drainage catheter is reserved after left and right abdominal cavity puncture to create an abdominal cavity drainage channel, an abdominal cavity outer port is sealed by a heparin cap after ascites concentration and reinfusion is finished, and when subsequent ascites concentration and reinfusion needs to be carried out on the next day, the heparin cap is used for sealing the abdominal cavity outer port. The closed ascites concentration and feedback pipeline can be formed again only by twisting down the heparin cap with the closed port and connecting the extracorporeal circulation blood path of the blood purification device, the hollow fiber dialyzer and the blood perfusion machine, and the second time, the third time or more times of ascites concentration and feedback are carried out. Therefore, repeated abdominal cavity puncture for multiple times of ascites concentration and reinfusion can be avoided, the pain of a patient and the risk of abdominal cavity infection caused in the puncture process are avoided, and the operation time and cost are saved.

This invention relates to the field of medical device testing technology, specifically to the application of LC-MS / MS in determining the content of indophenol sulfate and p-cresol sulfate in a hemoperfusion device. The method includes: mixing plasma and acetonitrile, vortexing and centrifuging, collecting the supernatant, eluting the supernatant through a C18 solid-phase extraction column, collecting the eluent, mixing the eluent with water and filtering to obtain the test solution; performing liquid chromatography and mass spectrometry on the test solution, wherein the mobile phase A of the liquid chromatography is a 3-8 mmol / L gradient concentration ammonium acetate solution containing 0.05% ammonium formate by volume, and the mobile phase B is methanol; S3: calculating the concentrations of indophenol sulfate and p-cresol sulfate in the test solution based on the labeled curve. This invention, through dual purification pretreatment and multi-ion-pair threshold matching technology, can effectively remove more than 95% of interfering protein-binding toxoids. The interference peak response value in blank plasma is less than 5% of the target analyte response value, solving the detection error problem caused by interference in traditional methods.

The invention discloses a method for evaluating the adsorption performance of a blood perfusion device to bilirubin. The method comprises the following steps: obtaining a hyperbilirubinemia rabbit model; and performing blood perfusion on the obtained hyperbilirubinemia rabbit model by using a blood perfusion device, calculating the adsorption rate of the blood perfusion device on bilirubin, and evaluating the adsorption performance of the adsorbent. According to the hyperbilirubinemia animal model, a rabbit is selected as a modeling object, the rabbit is subjected to intragastric administration with an induction reagent twice, and the hyperbilirubinemia rabbit model is obtained; the induction reagent is alpha-naphthyl isocyanate; the administration dosage of the induction reagent during the second time of intragastric administration is greater than that of the induction reagent during the first time of intragastric administration. According to the method, the animal model meeting the requirement for evaluating the adsorption performance of the bilirubin of the adsorbent in a perfusion mode can be rapidly established, the modeling method is simple and rapid, the modeling cost is low, the model operability is high, the adsorption performance of the adsorbent evaluated in the perfusion mode is closer to the clinical practical application condition, and the more accurate and objective evaluation effect is achieved.

The invention belongs to the technical field of blood purification, and discloses a protein binding toxoid adsorbent, a preparation method and application. The adsorbent is porous resin with a quaternary ammonium salt structure, and the porous resin is obtained by carrying out suspension polymerization reaction on a styrene monomer and a co-crosslinking agent; the co-crosslinking agent comprises divinyl benzene and methacrylamide ethylene glycol methyl ether. The adsorbent has excellent adsorption performance and blood compatibility, and effectively solves the problem of accumulation of protein binding toxoid in the body of a chronic kidney disease patient. During preparation, firstly, raw materials such as styrene monomers, divinyl benzene, methacrylamide ethylene glycol methyl ether and the like are subjected to suspension polymerization to prepare microspheres, and then tetramethyl diamine is grafted to the surfaces of the microspheres through quaternization reaction. The preparation method is simple in process, mild in reaction condition and high in safety. The adsorbent disclosed by the invention can be applied to the fields of preparation of blood perfusion devices and clinical removal of protein binding toxoid, and has a wide clinical application prospect.

The utility model provides a blood perfusion grade resin particle dispersion cleaning device which comprises a cleaning barrel used for providing a cleaning space for blood perfusion grade resin particle dispersion cleaning. The water inlet assembly is connected to the bottom of the cleaning barrel, and the water inlet assembly is used for pumping cleaning water into the cleaning barrel; the drain pipe is arranged on the side face of the cleaning barrel, and the drain pipe is used for discharging substances in the cleaning barrel. According to the multi-hole-site water inlet resin cleaning device, the amount of water required by all suspension of the multi-hole-site water inlet resin is extremely small, the cleaning cost is low, the cleaning efficiency is high, the resin cleaning effect is good, the use safety of the resin during blood perfusion is improved, meanwhile, the operation difficulty is low, and one operator can operate multiple devices at the same time for cleaning.

The utility model discloses a pre-filling flow path structure of a blood perfusion dialysis combined system, which comprises a public flow path, a perfusion flow path and a dialysis flow path, a perfusion device is arranged in the perfusion flow path, a dialyzer is arranged in the dialysis flow path, the perfusion flow path is connected with the dialysis flow path in parallel, and the dialyzer is connected with the public flow path in parallel. The perfusion flow path and the dialysis flow path are connected through a series flow path; a first switch valve and a second switch valve are arranged at the two ends of the perfusion device respectively, a third switch valve is arranged on the series connection flow path, and a fourth switch valve is arranged on the preceding stage flow path of the dialyzer. The parallel connection mode is adopted, the perfusion flow path and the dialysis flow path are connected, meanwhile, the series connection flow path is connected between the perfusion flow path and the dialysis flow path, and the connection state of the perfusion pipeline and the dialysis pipeline is adjusted through opening and closing of the first switch valve, the second switch valve, the third switch valve and the fourth switch valve; therefore, switching between series pre-charging and independent pre-charging is achieved, and bubbles are fully eliminated.

The utility model discloses an extracorporeal circulation blood path for hemodialysis and blood perfusion, which belongs to the technical field of medical instruments and comprises an arterial blood path and a venous blood path, and the arterial blood path comprises an aorta tube, a pump tube, an arterial pot inlet tube, an arterial pot outlet tube and an arterial pressure monitoring tube which are arranged along the flowing direction of arterial blood; the venous blood path comprises a venous pot inlet pipe, a venous pot outlet pipe, a hemodialyzer pipe and a venous pressure monitor which are arranged in the flowing direction of venous blood. The hemoperfusion device blood path comprises an artery connecting pipe, a vein connecting pipe, a waste liquid drainage pipe, an arteriovenous circulation pipe and a waste liquid bag connecting pipe. By means of the mode, connection needed by blood perfusion and connection needed by other blood purification modes (such as hemodialysis) are integrated together, medical staff do not need to splice various complex independent pipelines during operation, the operation process is simplified, and the hemodialysis efficiency is improved.

The utility model provides a blood perfusion adsorber, and belongs to the technical field of perfusion devices. The hemoperfusion device solves the problem that an existing hemoperfusion device is poor in sealing reliability due to the fact that end face sealing is adopted. The blood perfusion adsorber comprises a cylindrical shell, a filter screen rack, an end cover and a locking nut are arranged at the two ends of the shell respectively, the filter screen rack is located in the shell and abuts against an inner annular step of the shell, the end cover is located in the shell and pressed on the filter screen rack, the locking nut is pressed on the end cover, and the filter screen rack is located in the shell and abuts against the inner annular step of the shell. A sealing ring is arranged between the outer ring face of the end cover and the inner ring face of the shell, an internal thread is arranged on the locking nut, an external thread is arranged on the shell, and the cross section of the external thread and the cross section of the internal thread are in a right trapezoid shape. The sealing mode is radial sealing, and the extrusion degree of the sealing ring is irrelevant to the pre-tightening force of the threads; the end cover and the locking nut are designed in a split manner, and the required pretightening force is small, so that the sealing reliability is improved; the cross sections of the external threads and the internal threads are right-angled trapezoids, so that the creep resistance of the threads can be improved.

The application belongs to the technical field of biological medicine, and relates to a hemoperfusion adsorbent, a preparation method and application thereof. The hemoperfusion adsorbent is a microsphere structure, the carrier of the microsphere is a chitosan microsphere, the ligand is type I collagen, and the particle size of the microsphere is 250-1000 mu m. The hemoperfusion adsorbent provided in the application has the characteristics of large adsorption amount of bilirubin, high selective adsorption, small adsorption of albumin and the like based on the synergistic effect of collagen and chitosan, has excellent specific adsorption effect of bilirubin, is low in cost, and has good clinical application prospect.

The hemoperfusion device comprises a body, a first support is arranged on the outer surface of the body, a sliding platform is installed on the outer surface of an anti-collision plate in a sliding mode, and a rotating pushing mechanism is arranged between the anti-collision plate and the sliding platform. The body can be stably knocked by rotating the pushing mechanism, the labor intensity of medical staff is relieved, the damage probability of the body is reduced, and the treatment effect is improved. According to the hemoperfusion device with the knocking and trembling mechanism, when the hemoperfusion device is used, only the position of a sliding platform needs to be adjusted, then a motor can be started to drive a cam to rotate, the cam can push an impact spring rod, the impact spring rod can impact an anti-collision plate, and the body is protected through the anti-collision plate; bubbles and fine particles in the body can be knocked and vibrated by stable force, the probability that the body slips, is damaged and broken due to the fact that the knocking force is too large is reduced, and the labor force of medical workers can be liberated.

The utility model discloses a multifunctional hemoperfusion device flushing machine, and belongs to the technical field of blood purification. Comprising a clamping tool used for clamping a perfusion device; the upper butt joints and the lower butt joints are used for being in butt joint with the upper end and the lower end of a perfusion device and are communicated with the perfusion device. The upper main pipeline is communicated with the upper butt joint; the upper main pipeline is respectively connected with an upper vacuum valve, an upper air valve, an upper water inlet valve and an upper water outlet valve; the lower main pipeline is communicated with the lower butt joint; and the lower main pipeline is respectively connected with a lower vacuum valve, a lower air valve, a lower water inlet valve and a lower water outlet valve. The upper butt joint and the lower butt joint are connected to the upper main pipeline, pressure maintaining stop valves are installed in pipelines of the lower main pipeline respectively, and the upper butt joint is connected with a pressure sensor. According to the utility model, the clamping cylinder is matched with each control valve, so that the flushing machine integrates the functions of clamping, flushing, leak detection and the like, the operation efficiency and accuracy are greatly improved, and the risk and cost caused by quality problems are reduced.