166 results about "Hemoperfusion" patented technology

Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.

An endotoxin adsorbent used for blood perfusion is prepared from agat through adding the aqueous solution to the liquid mixture of toluene and CCl4 to obtain spherical agar, activating by epoxy chloropropane under alkaline condition, reacting on diamine and then on glutaraldehyde to obtain high-strength agar beads used as the carrier of adsorbent, reacting on the amino contained ligand (polymyxin B), and reducing by NaBH4. Its advantages are high compatibility to blood and high effect on absorbing endotoxin from blood.

The invention discloses an adsorbent for removing heavy metals through extracorporeal blood perfusion and a preparation method of the absorbent. Activating agents are used activating resin microsphere carriers with good biocompatibility, then sulihydryl reagents are fixed through bonding or coupling to form the heavy metal adsorbent, the surface of the heavy metal adsorbent is provided with a great quantity of sulihydryl functional groups and an adsorption effect through complexing or chelation between adsorption target liquid compositions and heavy metals and ions thereof is facilitated; the biocompatibility and the adsorption capacity are good; and the adsorbent has the characteristics of low preparation cost, simple synthesis process, strong adsorption capacity, rapid adsorption speed and the like, and can be used for extracorporeal whole-blood perfusion to remove in-vivo heavy metals and treat heavy metal poisoning.

The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.

The invention discloses a blood heavy metal ion adsorbent. With magnetic nano materials being carriers, the surfaces of the carriers are wrapped with ligand active groups in a modification mode, wherein the ligand active groups are capable of being combined with heavy metal ions and coordination compounds. The magnetic nano materials are magnetic iron-based compounds MFe2O4, wherein M is Fe2+ or Co2+ or Ni2+ or Zn2+ or Mg2+. The ligand active groups are one or more of -NH2, -SH2, -COOH and -OH. The invention further provides a preparation method of the blood heavy metal ion adsorbent and a blood perfusion device made from the blood heavy metal ion adsorbent. The surfaces of the magnetic nano-particles are modified, so that the blood heavy metal ion adsorbent is obtained and used for performing efficient selective or specific adsorption on one kind of heavy metal, it is avoided that because non-specific adsorption is performed on microelements in blood, the protein denatures and becomes inactive, and influences on the blood by the adsorbent and the risk of organism systematic complications are greatly reduced.

The invention relates to medical healthcare equipment, in particular to a wearable multi-field radiation whole-body hyperthermia device. Heat is introduced into a radiating target (i.e., a great vessel) by means of probe beams, and the energy of ultrasound, infrared, laser, microwave, radio frequency and electromagnetic probes at each frequency range is introduced into a vascular circulation system through the radiation probe network composed of probe beams distributed on an attachment in the form of optimum biological heat absorption, and then heat is transferred throughout the body through a hemoperfusion method, so that the vivo tissue is rapidly heated through conduction of biological heat in the tissue. The device has the characteristics of high thermal utilization ratio, high blood flow rate and high specific heat, and thermal convection is rapidly conducted between the radiant heat and the tissue to realize whole-body hyperthermia, therefore, the device not only can realize the purposes of uniformity of the machine body and rapid temperature rise, but also avoid the phenomenon of local overheating, simultaneously, has the accessibility of a wearable device and is a high-efficiency hyperthermia equipment without ache.

The invention provides a styrene system ion exchange resin as well as a preparation method and application thereof. The styrene system ion exchange resin is prepared by taking styrene and toluylene as monomers and is a milk-white nontransparent spherical particle; the diameter is 0.05-1.20 mm; the density is as follows: the true wet density is 1.06-1.10 g / ml, and the apparent wet density is 0.65-0.75 g / ml; the strength (attrited sphericity) is more than or equal to 95%; the surface active group is -N+(CH3)2; the aperture is 80-100 nanometers; the porosity is 45%-22%; the pore volume is 0.75-0.84 ml / g; the specific area is 850-1000 m<2> / g; the full exchange capacity of dry resin is 3.7 mmol / g, and the full exchange capacity of wet resin is 1.1 mmol / g. The styrene system ion exchange resin provided by the invention is an effective cell factor adsorbing material, achieves outstanding adsorption effect on endotoxins and inflammatory factors which are contained in blood and can be applied to the aspect of resin hemoperfusion apparatus.

The invention relates to an adsorbent used for clearing middle and macro molecule toxin in body of uremia patients and a preparation method thereof. According to the molecule size of middle and macromolecules such as beta2-MG, PTH, AGEs, Hcy and IL-6 and performance characteristics thereof, a functional adsorbent which can efficiently clear main middle and macro molecule toxins such as beta2-MG,PTH, AGEs, Hcy and IL-6 in the blood of the uremia patients is prepared by taking a mesoporous polystyrene hydrophobic resin as a carrier, which undergoes chloromethylation activation, and then performing chemical crosslinking grafting of vinylamine; and the adsorbent has large adsorption capacity, good mechanical strength, good biocompatibility and high adsorption selectivity. The adsorbent is used for treating uremia by blood perfusion, can take the advantages of blood filtering mainly for clearing micromolecular toxin, and provides a new method for treating uremia by combination of hematodialysis and blood perfusion.

The invention discloses a cytokine adsorbent for hemoperfusion and a preparation method thereof. The cytokine adsorbent for the hemoperfusion comprises a hydrophilic carrier used as an adsorbent substrate and a hydrophobic ligand fixed on the surface of the carrier by using chemical crosslinking, wherein the hydrophobic ligand is long chain pair alkylaniline with 4-18 carbon atoms and a derivant thereof. The cytokine adsorbent for the hemoperfusion has the advantages of good cytokine adsorption effect, high safety, low cost and the like.

The invention relates to an adsorbent used for adsorbing cholerythrin in extra corporeal blood perfusion and a preparation method thereof. The method takes polyvinyl alcohol microspheres with good biological compatibility as a carrier, adopts epoxy chloropropane for activation and fixes an amination agent as a functional group to form the cholerythrin adsorbent. The surface of the adsorbent is provided with a plurality of positive charges, which is beneficial to action with with the cholerythrin provided with negative charges on the surface to generate absorption effect. The adsorbent prepared by the invention has good biological compatibility and good adsorbing capacity, and is characterized by low manufacturing cost, simple synthesis process, large adsorbing volume, and high adsorbing speed, etc., and can be used in extra corporeal blood perfusion for curing hyperbilirubinemia.

The invention relates to a porous cellulose microsphere adsorbent used for blood perfusion and a preparation method thereof. According to the porous cellulose microsphere adsorbent, the grain sizes of prepared porous cellulose microspheres are 0.1-2mm, the inner hole sizes of the porous cellulose microspheres are mainly distributed in a range of 5nm-40nm, the specific surface area is 400-1,000m<2> / g, and the operating pressure capable of being resisted is 7-15bar. The preparation method is characterized by comprising the following steps of: obtaining the porous cellulose microspheres by utilizing an inverse suspension system, and then obtaining the porous cellulose microspheres capable of resisting the operating pressure of 7-15bar through cross linking, wherein the porous cellulose microspheres can be used as a carrier of a biomedical material or used as an adsorbent material for the blood perfusion.

The invention discloses a blood perfusion device having the anti-coagulation function and the controlled-release function and a manufacturing method of the blood perfusion device. The blood perfusion device comprises a perfusion device body provided with an adsorption chamber. The adsorption chamber contains an adsorbent and anti-coagulation and controlled-release gel having the thermosensitive characteristic. The anti-coagulation and controlled-release gel contains anti-coagulation matter. The anti-coagulation and controlled-release gel can be formed by dissolving the anti-coagulation matter, a compound with the two ends containing double bonds and a N-alkyl acrylamide type monomer having the thermosensitive characteristic in water through polymerization. By the adoption of the blood perfusion device having the anti-coagulation function and the controlled-release function, the anti-coagulation function is integrated with the blood purification function, the convenience of clinical blood perfusion is improved, and the risk of introducing pyrogen additionally is avoided; the thermosensitive characteristic and the mechanical property of the anti-coagulation and controlled-release gel can be adjusted by changing reactant components, the crosslinking density, the ion strength and the water content; when coagulation happens, coagulated blood clots can squeeze the anti-coagulation and controlled-release gel, so that release of the anti-coagulation matter can be instantly accelerated by the anti-coagulation and controlled-release gel, and the effect of effectively preventing the coagulation range from expanding is achieved.

A blood perfusion device for the external circulation of blood is composed of blood perfusion unit and controller consisting of detecting circuit, data processing unit, man-machine interactive unit, executing unit and pump driver unit. An artery pressure detector is arranged on the artery circulation loop of blood perfusion unit. Its functions include measuring the pressures of artery and vein and the temp of blood, sound-light alarm, data display, automatic heating, etc.

Provided herein is an innovative hemoperfusion system and method including a thermal-fused broad-spectrum biocidal iodinated interactive polymer for the treatment of biological contaminants in body fluids. In one exemplary embodiment, the system and method utilizes a Triosyn® thermal fused broad-spectrum iodinated interactive polymer, included in a hemoperfusion column, for devitalizing high levels of cell-free microorganisms in whole blood and biological fluids in relation with the characterization of blood cells viability and function post-treatment

The invention discloses an inflammatory factor adsorbing agent for blood perfusion and a preparation method. A framework of the inflammatory factor adsorbing agent is a carrier; and the surface of the carrier is in coupling with acetylated cysteine through an amidogen connecting arm. The carrier and the aglucon of the adsorbing agent can adsorb and remove inflammatory factors. Compared with a common adsorbing agent adsorbing the inflammatory factors by a carrier only, the inflammatory factor adsorbing agent has high removing ability. By the adsorbing agent, the inflammatory factors can be adsorbed from blood selectively, and the removing rate of the inflammatory factor adsorbing agent on IL-6 and TNF-alpha is much greater than that of a common poly (styrene-co-divinyl benzene) adsorbing agent. The adsorbing agent has high blood compatibility and can be used for whole blood perfusion.

The present invention relates to imprinted polymer nanoparticles. In particular, the present invention provides imprinted polymer nanopaticles polymerized in the presence of a target molecule (e.g., peptide), wherein the imprinted polymer nanoparticles comprise vinyl, acryl, and / or methacryl monomers, wherein the monomers have affinity for the target molecule. The present invention also relates to methods of using imprinted polymer nanoparticles in biomoacromolecular purification methods (e.g., to purify monoclonal antibodies or hormones), in toxin elimination methods (e.g., hemoperfusion), in diagnostics, in research, as well as in therapeutic methods (e.g., therapeutic methods where antisera or monoclonal antibodies are normally employed).

The invention provides a serum phosphate adsorbing agent; a hydrophilic carrier is immobilized by ligands capable of capturing phosphate ions to obtain the serum phosphate adsorbing agent; the hydrophilic carrier is selected from one or more out of cellulose, agarose and polyvinyl alcohol microsphere, and the ligands capable of capturing phosphate ions refer to amino polymers. The invention also provides a preparation method of the serum phosphate adsorbing agent and an adsorption column for blood perfusion, prepared by the serum phosphate adsorbing agent. Compared with medicines which are orally taken to act on the human body, the serum phosphate adsorbing agent can directly remove the phosphate ions in blood through blood circulation, so as to immediately alleviate the illness state of a patient; and the serum phosphate adsorbing agent can be combined with hemodialysis, oral taking pain of the patient each day can be reduced, and the result caused by a situation that the patient forgets to take the medicine can be avoided.

The invention provides a three-dimensional hemoperfusion image generation method and device based on electric impedance imaging. The method (100) comprises the following steps: performing electric impedance testing on human body areas to be tested by using electrode arrays distributed in a three-dimensional space so as to obtain electric impedance testing signals (110); and on the basis of hemoperfusion signals in the electric impedance testing signals, reconstructing a three-dimensional hemoperfusion image (120) by using an image reconstruction algorithm. Therefore, three-dimensional images of electric impedance variation caused by hemoperfusion can be generated, compared with two-dimensional images of the prior art, the three-dimensional images are capable of visibly reflecting hemoperfusion situations of one volume area in a three-dimensional space of a human body area, and image analysis and comparison and disease detection and diagnosis can be facilitated.

The invention relates to an adsorbent for removing endotoxin by blood perfusion and a preparation method thereof. The adsorbent uses a porous spherical synthesized high molecular material polyvinyl alcohol-triallyl isocyanurate copolymer as a carrier which has a rigid structure, great aperture and hydrophilic surfaces. The ligand is aliphatic diamine, and the carrier activated is coupled with the ligand by way of covalent bonds. The adsorbent is simple to prepare, good in stability, high in content of ligands and good in blood compatibility. The adsorbent is used by way of plasma or whole blood perfusion in blood purification to remove endotoxin in excessive content in blood of patients.

The invention provides a preparation method of a modified bilirubin adsorbent. According to the preparation method, a poly(HEMA-co-GMA)-PEI film-coated modified bilirubin adsorbent is obtained. The preparation method comprises the steps of with the bilirubin adsorbent for blood perfusion as a raw material, carrying out physical film coating treatment on the bilirubin adsorbent by virtue of a hydroxyethyl methylacrylate and glycidyl methacrylate copolymer (poly(HEMA-co-GMA)), processing film-coated bilirubin adsorbed resin by virtue of a polyethyleneimine (PEI) solution to graft amino to the poly(HEMA-co-GMA) film, so as to obtain the modified bilirubin adsorbent. According to the modified bilirubin adsorbent, the problem that micro-particles of an adsorbent fall during the blood perfusionis solved, the blood compatibility is improved, and the adsorption capacity of bilirubin is improved.

The invention discloses a hemoperfusion cartridge, which comprises a middle cylinder (1), glands (2), small blood nozzle cap (3) and filter screens. The two ends of the middle cylinder (1) are respectively sealed by one gland (2). A blood nozzle (2a) is arranged in the center of each gland (2) and is sealed by one small blood nozzle cap (3) in a pressing way. One filter screen is respectively installed in the middle cylinder (1) at a position close to the respective gland (2). An annular groove is arranged on the end surface of the opening end of each gland (2). The inner wall of the outer circumference of the annular groove is step-shaped. The end structure of the middle cylinder (1) is adaptive to the annular groove structure. The end (1d) of the middle cylinder is inserted into the annular groove for butt-connection, and the end (1d) of the middle cylinder and the annular groove are ultrasonically welded into a whole body. The invention has the advantages that the structure is simple, the design is unique, the glands and the middle cylinder structure are adaptive to ultrasonic welding, the sealing effect of the welded and formed hemoperfusion cartridge is good and the pollution is not apt to be caused; the small blood nozzle cap and the blood nozzle of the gland have unique three-dimensional sealing effect and the sealing is tight; and the number of components is reduced, the dies are reduced and the production cost and the manufacturing cost are greatly decreased.

The invention relates to macroporous adsorption resin for blood perfusion. A preparation method provided by the invention sequentially comprises the steps of free radical polymerization, surface grafting and post-crosslinking reaction. The macroporous adsorption resin provided by the invention is used as an adsorbent for hemoperfusion for uremia treatment, the macroporous adsorption resin for hemoperfusion comprises white balls formed by styrene monomers, polyvinyl monomers and third monomers, polyvinylpyrrolidone is grafted on the surfaces of the white balls, and the ultra-high cross-linkingmacroporous adsorption resin is formed through a post-cross-linking reaction. The preparation method is environmentally friendly, and the prepared macroporous adsorption resin for blood perfusion is low in solvent residual quantity and melt viscosity. The adsorption performance on macromolecular toxins such as parathyroid hormone and beta2-microglobulin is excellent, and the mechanical strength and biocompatibility are good.

The invention relates to a preparation method of a western blot polymeric adsorbent and an adsorption device. The preparation method comprises the following steps: step 1, siloxane monomers are mixedand uniformly dispersed under the conditions of nitrogen atmosphere and temperature lower than normal temperature; step 2, polymeric microspheres are subjected to amination and aldehyde treatment, anda pore forming agent is loaded; step 3, a protein aqueous solution and a mixture obtained in step 2 are uniformly dispersed in the mixture obtained in step 1, acid is added, and a condensation reaction is performed; step 4, the mixture obtained in step 3 is filtered, a product is washed to be neutral and dried, and the western blot polymeric adsorbent is prepared. The preparation method is simpleto operate, and the obtained western blot polymeric adsorbent is high in toxin adsorption rate and is particularly suitable for hemoperfusion of uremia.

Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.

The invention discloses a preparation method of an adsorption material for blood perfusion. The preparation method comprises the following steps: preparing an oil phase and a water phase, by a suspension polymerization process, preparing a macroporous adsorption resin precursor with the particle size distribution being 0.315-0.8 mm from the the prepared oil phase and water phase, carrying out chloromethylation on the prepared macroporous adsorption resin precursor to prepare a chloromethylated macroporous adsorption resin precursor, carrying out post-crosslinking on the prepared chloromethylated macroporous adsorption resin precursor to prepare macroporous adsorption resin of which the residual chlorine content is less than or equal to 2%, and carrying out post-treatment on the prepared macroporous adsorption resin to prepare the surface functionalized macroporous adsorption resin with adsorption capacity for blood perfusion. According to the invention, recycling of residual chloromethyl ether after the chloromethylation reaction in the synthesis process of the macroporous adsorption resin for blood perfusion is realized, and remarkable economic benefits and environmental protection benefits are brought.

A hemoperfusion bio-artificial liver system comprises a blood circulation portion, a bioreactor circulation portion and a cell renewing system portion; the three portions are communicated through a pipeline. The bioreactor circulation portion comprises a bio-artificial liver reactor unit composed of one or a plurality of bio-artificial liver reactors; outer space of the bio-artificial liver reactors is filled with L-02 cells to allow better therapeutic effect and safety. The cell renewing system portion is used for renewing the L-02 cells. The hemoperfusion bio-artificial liver system has the advantages that the therapeutic cells in the reactors can be renewed timely in the therapy process, continuous and stable therapeutic effect is guaranteed, interrupting the therapy to replace the reactors is not required, the therapeutic time is shortened, the whole system can be manually operated or full-automatically controlled via a PLC (programmable logic controller), the frequent sampling and detection is omitted for medical staff, real-time monitoring is achieved, and the system is efficient, safe, well practical and applicable to industrial production.

The invention belongs to the technical field of blood purification, and discloses a five-layer blood perfusion device and a blood perfusion method. The blood perfusion device comprises a perfusion device body, and a gel microsphere anticoagulant layer, a beta-2 microglobulin adsorption layer, a urea decomposition layer, an ammonia adsorption layer and an activated carbon adsorption layer are arranged in the perfusion device body in the direction of blood flow. The blood perfusion method comprises the steps of allowing blood to successively pass through the gel microsphere anticoagulant layer,the beta-2 microglobulin adsorption layer, the urea decomposition layer, the ammonia adsorption layer and the activated carbon adsorption layer. The five-layer blood perfusion device and the blood perfusion method have the advantages of comprehensive blood purification and good purification effect.

The invention relates to adsorption resin for blood perfusion and a preparation method thereof, and a perfusion device. The adsorption resin for blood perfusion is mainly formed by performing covalentlinkage on crosslinked polystyrene microspheres and polyamine compounds as well as grafting a multi-carboxyl chelating agent by the polyamine compounds. The preparation method comprises the steps ofaminating micrococcus chlorines, activating ligand and grafting. The perfusion device comprises the adsorption resin for blood perfusion. The adsorption resin for blood perfusion, which is provided orprepared by the invention, has high selective adsorption property on heavy metal and radionuclide, has high blood compatibility and is suitable for blood perfusion of human bodies or animal bodies.

The present invention is aimed at providing a blood cleaning equipment for curing haroinism and its application. Said equipment includes the following several portions: arterial blood path tube, blood pump on the blood dialyzer, blood dialyzer main machine, anticoagulative heparin pump for continuously injecting heparin, blood perfusion device, blood dialyzer, dialysate input pipeline, dialysate output pipeline, venous pressure monitor, venous air bubble-removing device, air monitor, venous clamp and venous blood path tube.