163 results about "Hemoperfusion" patented technology

Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β₂-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.

The invention relates to medical healthcare equipment, in particular to a wearable multi-field radiation whole-body hyperthermia device. Heat is introduced into a radiating target (i.e., a great vessel) by means of probe beams, and the energy of ultrasound, infrared, laser, microwave, radio frequency and electromagnetic probes at each frequency range is introduced into a vascular circulation system through the radiation probe network composed of probe beams distributed on an attachment in the form of optimum biological heat absorption, and then heat is transferred throughout the body through a hemoperfusion method, so that the vivo tissue is rapidly heated through conduction of biological heat in the tissue. The device has the characteristics of high thermal utilization ratio, high blood flow rate and high specific heat, and thermal convection is rapidly conducted between the radiant heat and the tissue to realize whole-body hyperthermia, therefore, the device not only can realize the purposes of uniformity of the machine body and rapid temperature rise, but also avoid the phenomenon of local overheating, simultaneously, has the accessibility of a wearable device and is a high-efficiency hyperthermia equipment without ache.

The invention relates to an adsorbent used for clearing middle and macro molecule toxin in body of uremia patients and a preparation method thereof. According to the molecule size of middle and macromolecules such as beta2-MG, PTH, AGEs, Hcy and IL-6 and performance characteristics thereof, a functional adsorbent which can efficiently clear main middle and macro molecule toxins such as beta2-MG,PTH, AGEs, Hcy and IL-6 in the blood of the uremia patients is prepared by taking a mesoporous polystyrene hydrophobic resin as a carrier, which undergoes chloromethylation activation, and then performing chemical crosslinking grafting of vinylamine; and the adsorbent has large adsorption capacity, good mechanical strength, good biocompatibility and high adsorption selectivity. The adsorbent is used for treating uremia by blood perfusion, can take the advantages of blood filtering mainly for clearing micromolecular toxin, and provides a new method for treating uremia by combination of hematodialysis and blood perfusion.

The invention discloses a cytokine adsorbent for hemoperfusion and a preparation method thereof. The cytokine adsorbent for the hemoperfusion comprises a hydrophilic carrier used as an adsorbent substrate and a hydrophobic ligand fixed on the surface of the carrier by using chemical crosslinking, wherein the hydrophobic ligand is long chain pair alkylaniline with 4-18 carbon atoms and a derivant thereof. The cytokine adsorbent for the hemoperfusion has the advantages of good cytokine adsorption effect, high safety, low cost and the like.

The invention relates to an adsorbent used for adsorbing cholerythrin in extra corporeal blood perfusion and a preparation method thereof. The method takes polyvinyl alcohol microspheres with good biological compatibility as a carrier, adopts epoxy chloropropane for activation and fixes an amination agent as a functional group to form the cholerythrin adsorbent. The surface of the adsorbent is provided with a plurality of positive charges, which is beneficial to action with with the cholerythrin provided with negative charges on the surface to generate absorption effect. The adsorbent prepared by the invention has good biological compatibility and good adsorbing capacity, and is characterized by low manufacturing cost, simple synthesis process, large adsorbing volume, and high adsorbing speed, etc., and can be used in extra corporeal blood perfusion for curing hyperbilirubinemia.

The invention discloses a blood perfusion device having the anti-coagulation function and the controlled-release function and a manufacturing method of the blood perfusion device. The blood perfusion device comprises a perfusion device body provided with an adsorption chamber. The adsorption chamber contains an adsorbent and anti-coagulation and controlled-release gel having the thermosensitive characteristic. The anti-coagulation and controlled-release gel contains anti-coagulation matter. The anti-coagulation and controlled-release gel can be formed by dissolving the anti-coagulation matter, a compound with the two ends containing double bonds and a N-alkyl acrylamide type monomer having the thermosensitive characteristic in water through polymerization. By the adoption of the blood perfusion device having the anti-coagulation function and the controlled-release function, the anti-coagulation function is integrated with the blood purification function, the convenience of clinical blood perfusion is improved, and the risk of introducing pyrogen additionally is avoided; the thermosensitive characteristic and the mechanical property of the anti-coagulation and controlled-release gel can be adjusted by changing reactant components, the crosslinking density, the ion strength and the water content; when coagulation happens, coagulated blood clots can squeeze the anti-coagulation and controlled-release gel, so that release of the anti-coagulation matter can be instantly accelerated by the anti-coagulation and controlled-release gel, and the effect of effectively preventing the coagulation range from expanding is achieved.

A blood perfusion device for the external circulation of blood is composed of blood perfusion unit and controller consisting of detecting circuit, data processing unit, man-machine interactive unit, executing unit and pump driver unit. An artery pressure detector is arranged on the artery circulation loop of blood perfusion unit. Its functions include measuring the pressures of artery and vein and the temp of blood, sound-light alarm, data display, automatic heating, etc.

The invention discloses an inflammatory factor adsorbing agent for blood perfusion and a preparation method. A framework of the inflammatory factor adsorbing agent is a carrier; and the surface of the carrier is in coupling with acetylated cysteine through an amidogen connecting arm. The carrier and the aglucon of the adsorbing agent can adsorb and remove inflammatory factors. Compared with a common adsorbing agent adsorbing the inflammatory factors by a carrier only, the inflammatory factor adsorbing agent has high removing ability. By the adsorbing agent, the inflammatory factors can be adsorbed from blood selectively, and the removing rate of the inflammatory factor adsorbing agent on IL-6 and TNF-alpha is much greater than that of a common poly (styrene-co-divinyl benzene) adsorbing agent. The adsorbing agent has high blood compatibility and can be used for whole blood perfusion.

The invention provides a serum phosphate adsorbing agent; a hydrophilic carrier is immobilized by ligands capable of capturing phosphate ions to obtain the serum phosphate adsorbing agent; the hydrophilic carrier is selected from one or more out of cellulose, agarose and polyvinyl alcohol microsphere, and the ligands capable of capturing phosphate ions refer to amino polymers. The invention also provides a preparation method of the serum phosphate adsorbing agent and an adsorption column for blood perfusion, prepared by the serum phosphate adsorbing agent. Compared with medicines which are orally taken to act on the human body, the serum phosphate adsorbing agent can directly remove the phosphate ions in blood through blood circulation, so as to immediately alleviate the illness state of a patient; and the serum phosphate adsorbing agent can be combined with hemodialysis, oral taking pain of the patient each day can be reduced, and the result caused by a situation that the patient forgets to take the medicine can be avoided.

The invention provides a three-dimensional hemoperfusion image generation method and device based on electric impedance imaging. The method (100) comprises the following steps: performing electric impedance testing on human body areas to be tested by using electrode arrays distributed in a three-dimensional space so as to obtain electric impedance testing signals (110); and on the basis of hemoperfusion signals in the electric impedance testing signals, reconstructing a three-dimensional hemoperfusion image (120) by using an image reconstruction algorithm. Therefore, three-dimensional images of electric impedance variation caused by hemoperfusion can be generated, compared with two-dimensional images of the prior art, the three-dimensional images are capable of visibly reflecting hemoperfusion situations of one volume area in a three-dimensional space of a human body area, and image analysis and comparison and disease detection and diagnosis can be facilitated.

The invention relates to an adsorbent for removing endotoxin by blood perfusion and a preparation method thereof. The adsorbent uses a porous spherical synthesized high molecular material polyvinyl alcohol-triallyl isocyanurate copolymer as a carrier which has a rigid structure, great aperture and hydrophilic surfaces. The ligand is aliphatic diamine, and the carrier activated is coupled with the ligand by way of covalent bonds. The adsorbent is simple to prepare, good in stability, high in content of ligands and good in blood compatibility. The adsorbent is used by way of plasma or whole blood perfusion in blood purification to remove endotoxin in excessive content in blood of patients.

The invention discloses a hemoperfusion cartridge, which comprises a middle cylinder (1), glands (2), small blood nozzle cap (3) and filter screens. The two ends of the middle cylinder (1) are respectively sealed by one gland (2). A blood nozzle (2a) is arranged in the center of each gland (2) and is sealed by one small blood nozzle cap (3) in a pressing way. One filter screen is respectively installed in the middle cylinder (1) at a position close to the respective gland (2). An annular groove is arranged on the end surface of the opening end of each gland (2). The inner wall of the outer circumference of the annular groove is step-shaped. The end structure of the middle cylinder (1) is adaptive to the annular groove structure. The end (1d) of the middle cylinder is inserted into the annular groove for butt-connection, and the end (1d) of the middle cylinder and the annular groove are ultrasonically welded into a whole body. The invention has the advantages that the structure is simple, the design is unique, the glands and the middle cylinder structure are adaptive to ultrasonic welding, the sealing effect of the welded and formed hemoperfusion cartridge is good and the pollution is not apt to be caused; the small blood nozzle cap and the blood nozzle of the gland have unique three-dimensional sealing effect and the sealing is tight; and the number of components is reduced, the dies are reduced and the production cost and the manufacturing cost are greatly decreased.

The invention relates to a preparation method of a western blot polymeric adsorbent and an adsorption device. The preparation method comprises the following steps: step 1, siloxane monomers are mixedand uniformly dispersed under the conditions of nitrogen atmosphere and temperature lower than normal temperature; step 2, polymeric microspheres are subjected to amination and aldehyde treatment, anda pore forming agent is loaded; step 3, a protein aqueous solution and a mixture obtained in step 2 are uniformly dispersed in the mixture obtained in step 1, acid is added, and a condensation reaction is performed; step 4, the mixture obtained in step 3 is filtered, a product is washed to be neutral and dried, and the western blot polymeric adsorbent is prepared. The preparation method is simpleto operate, and the obtained western blot polymeric adsorbent is high in toxin adsorption rate and is particularly suitable for hemoperfusion of uremia.

A hemoperfusion bio-artificial liver system comprises a blood circulation portion, a bioreactor circulation portion and a cell renewing system portion; the three portions are communicated through a pipeline. The bioreactor circulation portion comprises a bio-artificial liver reactor unit composed of one or a plurality of bio-artificial liver reactors; outer space of the bio-artificial liver reactors is filled with L-02 cells to allow better therapeutic effect and safety. The cell renewing system portion is used for renewing the L-02 cells. The hemoperfusion bio-artificial liver system has the advantages that the therapeutic cells in the reactors can be renewed timely in the therapy process, continuous and stable therapeutic effect is guaranteed, interrupting the therapy to replace the reactors is not required, the therapeutic time is shortened, the whole system can be manually operated or full-automatically controlled via a PLC (programmable logic controller), the frequent sampling and detection is omitted for medical staff, real-time monitoring is achieved, and the system is efficient, safe, well practical and applicable to industrial production.

The invention belongs to the technical field of blood purification, and discloses a five-layer blood perfusion device and a blood perfusion method. The blood perfusion device comprises a perfusion device body, and a gel microsphere anticoagulant layer, a beta-2 microglobulin adsorption layer, a urea decomposition layer, an ammonia adsorption layer and an activated carbon adsorption layer are arranged in the perfusion device body in the direction of blood flow. The blood perfusion method comprises the steps of allowing blood to successively pass through the gel microsphere anticoagulant layer,the beta-2 microglobulin adsorption layer, the urea decomposition layer, the ammonia adsorption layer and the activated carbon adsorption layer. The five-layer blood perfusion device and the blood perfusion method have the advantages of comprehensive blood purification and good purification effect.

The present invention is aimed at providing a blood cleaning equipment for curing haroinism and its application. Said equipment includes the following several portions: arterial blood path tube, blood pump on the blood dialyzer, blood dialyzer main machine, anticoagulative heparin pump for continuously injecting heparin, blood perfusion device, blood dialyzer, dialysate input pipeline, dialysate output pipeline, venous pressure monitor, venous air bubble-removing device, air monitor, venous clamp and venous blood path tube.

The invention discloses a blood purification adsorbing agent for restraining grown and transfer of tumor and application of the blood purification adsorbing agent. The adsorbing agent takes natural macromolecule or synthetic macromolecule as a carrier, a biological cross-linking agent or a chemical crosslinking agent as an arm, natural small molecules or large molecules with polyhydric group and acidity or basic group with an affine adsorptive action with cell factors (such VEGF, bFGF, MMP-9,TGF,IL and the like) in the tumor microenvironment, or artificially synthesized small molecules or macromolecule substances as a genin; the carrier, the arm and the genin are combined through a biological or chemical synthesizing method, and the adsorbing agent for selectively removing cell factors promoting tumor grown or transfer in patient blood is prepared. The blood purification adsorbing agent provided by the invention selectively removes cell factors promoting tumor grown or transfer in blood by adopting a blood perfusion method, so that the suitable microenvironment for tumor growth is eliminated, the cell factors are effectively antagonized so as not to promote tumor tumorigenesis and progression, meanwhile, an immune system is also protected, and cancer growth or cancer metastasis is prevented.