151 results about "Anticoagulant" patented technology

The invention relates to the technical field of intelligent materials, in particular to low-temperature-resistant magnetorheological fluid and a preparation method thereof.The low-temperature-resistant magnetorheological fluid is prepared from, by weight, 60-75 parts of magnetic particles; 3 to 15 parts of modified magnetic particles; 10-25 parts of low-temperature-based carrier liquid, which comprises 40-60% of silicone oil and / or mineral oil, 20-30% of synthetic ester and 10-20% of poly-alpha-olefin; 0.1 to 1.0 part of a dispersant; 0.5 to 2.0 parts of an anticoagulant; wherein the modified magnetic particles are prepared by coating magnetic particles with SiO2 aerogel and grafting the coated magnetic particles with fluorine-containing silane; the preparation method comprises the steps that magnetic particles are sequentially subjected to silane coupling agent treatment, aerogel deposition and fluorine-containing silane gas-phase grafting, and modified magnetic particles are prepared; carrying out ultrasonic mixing on the base carrier liquid and an anticoagulant at 40-60 DEG C for 30 minutes; adding magnetic particles, modified magnetic particles and a dispersing agent, dispersing by adopting a micro-jet homogenizer, and then carrying out gradient cooling treatment. The low-temperature-resistant magnetorheological fluid has the effect of improving the low-temperature-resistant performance of the magnetorheological fluid.

The invention belongs to the technical field of blood detection, and particularly relates to an experimental animal blood detection device which comprises a detector body and a sample injection needle, and further comprises a sample mixing part, and the sample mixing part comprises a disc rotationally installed on the detector body; the fixing bases are installed on the disc, and clamping assemblies are rotationally installed on the fixing bases; the driving assembly is installed on the fixing base and comprises a main shaft rotationally installed on the fixing base and an auxiliary shaft used for driving the clamping jaw to rotate, a plurality of sets of auxiliary gears and main gears are installed on the auxiliary shaft and the main shaft respectively, the tooth ratios of the auxiliary gears and the main gears in each set are different, and the auxiliary shaft is of a telescopic structure; by arranging the driving assembly, different shaking speeds are adopted for blood collection tubes of different specifications, it is ensured that blood and an anticoagulant are evenly mixed, the situation of hemolysis or uneven mixing is avoided, and the detection accuracy and efficiency are improved.

The invention relates to the field of preparation of amino acid water-soluble fertilizers, and discloses a method for preparing an amino acid-containing water-soluble fertilizer by using slaughtering blood of bred livestock and poultry, which comprises the following steps: collecting the blood of the bred livestock and poultry in a slaughter house through a blood collection container, and adding an anticoagulant to obtain an anticoagulant raw material; the preparation method comprises the following steps: heating and disinfecting an anticoagulant raw material, and then adding bacillus subtilis and monopotassium phosphate to carry out enzymolysis treatment, so as to obtain a feed liquid after enzymolysis; then filtering, complexing treatment, ultraviolet sterilization treatment and sterilization are carried out in sequence; carrying out amino acid detection on the sterilized material liquid subjected to enzymolysis, and adding other nutrients to form an organic liquid fertilizer containing amino acid; and finally, carrying out preservative treatment, packaging and warehousing, and storing in a shade place to complete the preparation process of the amino acid water-soluble fertilizer. The invention solves the problems that the existing amino acid water-soluble fertilizer preparation raw materials are less, the amino acid water-soluble fertilizer preparation process is longer, and the environment is polluted due to the discharge of livestock and poultry slaughtering blood waste.

The invention discloses a preparation method and application of a response type NO release anticoagulant hydrogel material. The preparation method comprises the following steps: providing methylacryloylated recombinant collagen; providing methacrylated hyaluronic acid; providing caffeic acid arginine amide modified hyaluronic acid; the response type NO release anticoagulant hydrogel material is obtained by taking methylacryloylated recombinant collagen, methylacryloylated hyaluronic acid and caffeic acid arginine amide modified hyaluronic acid as raw materials. The prepared hydrogel material has the advantages of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like, arginine can serve as an endogenous NO donor in blood to release NO molecules, and therefore the effect of promoting vascular endothelial repair is achieved, and the hydrogel material has the advantages of being capable of resisting bacteria, promoting proliferation of endothelial cells, inhibiting proliferation of smooth muscle cells, resisting inflammation, promoting angiogenesis, inhibiting thrombosis and the like. The introduced NO molecules enable the hydrogel material to have good anticoagulant performance, and the hydrogel material is expected to be used for preparing an artificial blood vessel anticoagulant coating.

The invention discloses cattle whole blood collection equipment, relates to the technical field of cattle whole blood collection, and aims to solve the technical problems that the proportion of an anticoagulant and blood is difficult to control, the collection efficiency and quality are low, and the blood is easy to coagulate, and the sample loss risk is increased in the current collection equipment. After the blood drip cup is connected to the bovine blood collection equipment, the collected bovine blood is conveyed to one end of the mixing assembly through the peristaltic pump, the anticoagulant is conveyed to the other end of the mixing assembly through the anticoagulant tube according to the preset proportion and flow through the other peristaltic pump, the blood and the anticoagulant are fully converged and fused in the mixing assembly, and the blood collection efficiency is improved. The bovine whole blood can be rapidly and uniformly mixed together, the blood coagulation tendency is inhibited, and it is ensured that the collected bovine whole blood keeps good fluidity and activity in the follow-up treatment and storage process. The cattle whole blood collection efficiency and quality are improved, and the sample loss and experimental error risks caused by blood coagulation are reduced.

The invention discloses an extraction method of leech anticoagulant protein, and belongs to the technical field of biological extraction.According to the extraction method, after components of induction liquid are optimized, mucous membranes are activated, and the living tissue environment naturally sucked by leeches is simulated, so that the leeches can be induced to better suck, the sucking amount of the leeches is guaranteed, and the anti-coagulation protein content of the leeches is improved; the leeches can be effectively stimulated to secrete more anticoagulant proteins with higher activity; meanwhile, under the coordination effect of the tranquilizer, the leech is kept in a warm state, so that the silent and relaxed physiological state of the leech can still be ensured in a dizziness stimulation or air pressure difference stimulation state, the loss of the living leech can be reduced, conditions for repeated extraction are provided for the leech, the gland secretion activity of the leech tends to be stable and vigorous, and the survival rate of the leech is increased. The extraction rate is further improved.

The invention discloses a specimen sampling device based on medical detection, and relates to the technical field of blood sampling, the specimen sampling device comprises a vacuum blood collection tube, a blood collection needle and a fixator, the vacuum blood collection tube comprises a bottle tube and a bottle cap, the fixator comprises a positioning frame, a sliding block, a puncture needle, a first spring, a second spring and a buckle, and a mounting groove is formed in the upper end face of the positioning frame; the vacuum blood collection tube is detachably installed in the installation groove, the sliding block is installed in the installation groove and is in elastic sliding connection with the positioning frame through a first spring, the puncture needle is installed in the sliding block and is in elastic sliding connection with the positioning frame through a second spring, and a hose is arranged between the blood collection needle and the puncture needle. The blood sampling device has the advantages of being convenient to operate and capable of automatically mixing the anticoagulant, and the problems that according to existing blood sampling equipment, medical staff need to operate with two hands, the blood sampling part of a patient is fixed with one hand, operation is complex, misoperation is prone to occurring, and the process of manually replacing a blood sampling bottle and shaking and mixing the anticoagulant is long in time consumption and low in efficiency are solved.

The present disclosure provides a method to determine whether or not a patient has received administration of a direct oral anticoagulant (DOAC). The present disclosure provides a method comprising allowing magnetic particles in a reagent to move after the addition of a sample to a dry reagent containing magnetic particles, monitoring the movement signal of the magnetic particles, analyzing the monitored movement signal of the magnetic particles, and comparing the results of analysis with a threshold, and a program and an apparatus used for such method.

The invention relates to the technical field of biological materials, in particular to a local anticoagulation acellular bone matrix composite material and a preparation method thereof.The preparation method comprises the following steps that S1, bone tissue is obtained and treated, and an acellular bone matrix is prepared; s2, mixing an anticoagulant with the acellular bone matrix to form an anticoagulant compound; s3, mixing the anticoagulant compound with a biocompatible carrier to form a final composite material; and S4, preparing the composite material into an implant or a stent with a required shape through a molding and curing process. By arranging the acellular bone matrix, the natural structure and biological activity of the bone matrix are reserved to the maximum extent, and meanwhile, all cell components are removed, so that immunogenicity and pathogen transmission are reduced; by adding the anticoagulant, discomfort can be reduced after the local anticoagulant acellular bone matrix composite material is implanted into a human body, and the problems that in the prior art, an acellular bone matrix has the blood coagulation risk, and incompletely-treated bone tissue has immunological rejection are solved.

The invention discloses an antibacterial high-water-absorption sanitary napkin and a preparation method thereof.The antibacterial high-water-absorption sanitary napkin sequentially comprises a bottom film, an absorption core and a skin-friendly layer from bottom to top, and the absorption core is prepared from, by weight, 15-35 parts of sodium polyacrylate, 15-30 parts of polyacrylamide, 20-30 parts of PET, 6-12 parts of carboxymethylcellulose, 2-6 parts of anticoagulant, 2-6 parts of polyvinyl alcohol and 1-3 parts of silver-loaded nano silicon dioxide; the prepared antibacterial high-water-absorption sanitary napkin not only has good absorptivity, but also has a good antibacterial effect.

The invention relates to the field of medical instruments, in particular to a composite heparin anticoagulant coating and a preparation method thereof. The method comprises the following steps: ultraviolet light pretreatment: carrying out ultraviolet light pretreatment on a substrate material to initiate polyethyleneimine to be grafted on the surface of the material; turning coating: coating the surface of the substrate material with a heparin solution, and fixing with an EDC solution; and the coating direction is changed in the coating process. Amino chains are introduced to the surface of a substrate material through ultraviolet light, the surface is provided with positive charges, and the heparin coating is formed through ionic bond combination. After the coating is completed, the coating is fixed by using an EDC solution, and the coating direction is changed in the coating process, so that the stability, the uniformity, the hydrophilicity and the anticoagulation performance of the coating are improved.

The invention discloses an anticoagulation endothelium slow release promoting coating and a preparation method thereof, and relates to the technical field of biomedical materials, the method comprises the following steps: soaking a substrate material in a guide layer solution prepared from dopamine, a silane coupling agent containing double bonds and an amino compound; immersing in an assembly layer solution prepared from a double-bond functionalized high-molecular compound and an endothelial active promoting substance, taking out, and carrying out photo-crosslinking curing; and immersing in a regulation and control layer solution prepared from a double-bond functionalized high-molecular compound and a zwitterionic monomer, and finally taking out for photo-crosslinking and curing to obtain the anti-coagulation endothelial sustained-release promoting coating. According to the method, efficient packaging and slow release of anticoagulation and endothelialization promoting active substances are achieved, and the prepared coating remarkably improves the performance of a blood contact instrument in the aspects of acute-stage thrombus formation resistance and long-acting endothelialization promotion after implantation.

The invention discloses a method for evaluating influence of traditional Chinese medicine on warfarin anticoagulant efficacy based on a PK / PD theory, and belongs to the technical field of medicine evaluation. In order to clarify the material basis and the influence degree of traditional Chinese medicine on warfarin anticoagulation, the method comprises the following steps: carrying out grouped animal experiments, then respectively collecting pharmacodynamic experiment data, drug absorption experiment data, drug metabolism experiment data, drug plasma protein binding rate experiment data and drug excretion experiment data, and constructing a multi-dimensional data set; performing preprocessing, including removing abnormal values and performing data standardization processing to obtain a preprocessed data set; performing dimension reduction analysis by using a principal component analysis (PCA), extracting main components, and generating a score matrix and a load matrix; performing orthogonal partial least square discriminant analysis on the score matrix, and classifying the data based on an orthogonal partial least square discriminant analysis method to obtain a classification result; and obtaining an evaluation result of the influence of the traditional Chinese medicine on the warfarin anticoagulant efficacy based on the obtained classification result. The method is accurate in evaluation.

The invention aims to provide a traditional Chinese medicine compound pill for treating femoral head necrosis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine compound pill for treating femoral head necrosis is prepared on the basis of ground beetles, leeches, pseudo-ginseng, rhizoma drynariae, eucommia ulmoides, herba epimedii, turmeric, red ginseng and exocarpium citri grandis. Long-term clinical practice and examination show that the traditional Chinese medicine compound pill has an obvious curative effect on ischemic necrosis of femoral head, especially has an obvious treatment effect on patients with early-stage femoral head necrosis, and avoids side effects such as jaw necrosis and diabetes induced by western medicines such as anticoagulants, statins and anti-osteoporosis medicines; the medicine is convenient to take, does not need to be decocted for a long time by using a professional vessel, and is not limited by time and space; operation treatment is avoided or delayed to a certain extent, and the advantages and effects of oral administration treatment of traditional Chinese medicine are fully exerted.

The present invention discloses an ultrasound-driven coating for promoting vascular tissue repair, and a preparation method and application thereof, which belongs to the technical field of medical biological coating materials. The present invention first dissolves a piezoelectric material and an anticoagulant in a solvent to obtain an electrostatic spinning solution, and obtains highly oriented nanofibers after spinning of the electrostatic spinning solution, and then obtains an ultrasound-driven coating for promoting vascular tissue repair after drying and annealing the nanofibers; this coating can respond to external ultrasonic signals to generate vibrations or electric fields; it has good biocompatibility and can be used to coat modified medical implant materials; the modified cardiovascular implant intervention device can effectively control the release of anticoagulants in time and space by adjusting the exogenous ultrasonic frequency, and trigger adjustable related stimulation signals, synergistically achieve anticoagulation and in situ endothelialization, effectively promote vascular tissue repair, and thus provide patients with personalized treatment plans.

The invention discloses a blood filtering membrane preparation device and method, and belongs to the technical field of blood filtering membrane preparation. The method comprises the steps that materials are prepared, a membrane material is polyethersulfone, a solvent is a mixed solvent and specifically comprises N-methyl pyrrolidone (NMP) and gamma-butyrolactone, additives comprise a pore-forming agent, an anticoagulant and bioactive molecules, and the bioactive molecules are heparin. A spinning solution is uniformly dispersed through the ultrasonic dispersion instrument and the magnetic stirrer, the agglomeration state of a membrane material and an additive in a solvent is effectively broken through through the strong vibration and cavitation effect of the ultrasonic dispersion instrument, and full contact and mixing of all components are promoted; therefore, the uniformity of a mixed solution before spinning is remarkably improved, a blood filtering film forming structure is more compact, pore distribution is more uniform, the spinning solution is stirred in cooperation with a magnetic stirrer, agglomeration of particles in the spinning solution is reduced, and the uniformity and stability of the spinning solution can be more effectively improved.

The utility model provides a prefilled anticoagulant temporary storage device which comprises a barrel body and opening and closing strips, a top cover is detachably arranged on the top of the barrel body, an installation block is arranged on the top of the top cover, a plurality of containing pipes are vertically arranged on the installation block in a penetrating mode, each containing pipe is communicated with the barrel body, and the opening and closing strips correspond to the containing pipes one to one. Each opening and closing strip is horizontally and slidably arranged on the mounting block in a penetrating mode, a strip-shaped groove allowing the opening and closing strip to be inserted is formed in the side wall of each containing pipe, and the problem that in the prior art, when medical staff recheck the type and dosage of the pre-filled anticoagulant, the risk that the medical staff are punctured by a needle head exists is solved.

The invention relates to a blood contact material and a preparation method thereof. The preparation method of the blood contact material comprises the following steps that the anticoagulant layer is covalently connected to the surface of the base material in an atom transfer radical polymerization mode, the tail end of a polymer in the anticoagulant layer is provided with an initiator group, and the anticoagulant layer comprises one or more of a hydrophilic anticoagulant layer and a heparin anticoagulant layer; and reacting the initiator group with the substance with the NO catalytic release function to prepare the blood contact material. According to the preparation method, the stability of the membrane layer can be improved while a relatively good antithrombotic effect is ensured.

Provided herein are novel methods, compositions, and kits for targeting antithrombotic (LTAT) molecules using lymph. The LTAT molecule can be used for treating or preventing lymphatic thrombosis caused by infection or inflammation, in particular in the intestinal tract.

The invention relates to a portable automatic blood purification system, and belongs to the technical field of blood purification medical equipment. The system comprises an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube and a blood outlet tube. The artificial kidney unit comprises a first peristaltic pump, a second peristaltic pump, a first dialyzer, a fourth peristaltic pump, an anticoagulant container and an injection pump; the artificial liver unit comprises a second dialyzer, a hemoperfusion device, an albumin storage container and a third peristaltic pump; the device is characterized by further comprising an artificial lung unit composed of an oxygen container, and the oxygen container is connected between the second outlet of the second compartment of the first dialyzer and the inlet of the second peristaltic pump in parallel through two switches. The device is provided with an emergency life maintenance function device combining the artificial kidney, the artificial liver and the artificial lung, the artificial lung unit is additionally arranged, and when a patient is in a coma condition, timely treatment is achieved by conveying oxygen. The invention is suitable for war, serious injury, burn, poisonous snake and insect bites, pesticide poisoning and other occasions.

The utility model relates to the technical field of medical instruments, in particular to a blood sampling test tube placing rack for outpatient nursing, which comprises a fixing frame, a rotating shaft, a placing frame, a small motor and the like. The left side and the right side of the top of the fixing frame are rotationally connected with at least three rotating shafts, a placing frame is connected between the left rotating shaft and the right rotating shaft, each placing frame is provided with at least five inserting holes allowing test tubes to be inserted, a small motor is installed on one side of the fixing frame, and an output shaft of the small motor is fixedly connected with the rotating shaft in the middle. Due to the arrangement of the placing frames, the rotating shaft, the transmission belt and the small motor, the placing frames rotate along the rotating shaft under the transmission action of the transmission belt, so that blood and an anticoagulant in a test tube are fully mixed, the effectiveness of blood sampling is ensured, manual shaking up is not needed, the mixing efficiency of the blood and the anticoagulant is improved, time can be saved, and the working efficiency is improved. And a fixing block, a clamping block and a connecting spring are further arranged, so that the clamping block can be clamped and fixed, and the test tube is prevented from being thrown out of the placing frame during rotation.

The invention relates to the technical field of medical precious metal materials and medical instruments, in particular to a gold surface anticoagulation coating structure and a preparation method and application thereof. According to the method, a micro-nano morphology surface is constructed on the surface of a gold layer through in-situ wet chemical reduction of chloroauric acid, the surface of the micro-nano gold layer is modified through fluoromercaptan, a lubricating agent is injected into the modified micro-nano gold surface, and a lubricating agent injected porous self-lubricating surface (SLIPS) is constructed; the locking capacity of the surface of the nano-gold layer modified by fluoromercaptan to the lubricating layer is remarkably improved, so that the lubricating layer is not prone to loss, and the long-lasting anticoagulation function is achieved. The problems that when a liquid injection surface method is adopted for conducting anticoagulation treatment on the surface of a material, injected lubricating liquid is prone to being exhausted, and the anticoagulation performance durability is poor are solved.

The invention belongs to the technical field of biology, and relates to an anticoagulant fusion protein HSA-Qinghaenin (c), a coding gene and application thereof, in particular to preparation of the anticoagulant fusion protein and application of the anticoagulant fusion protein in the fields of prevention of in-vivo thrombus formation and preparation of anticoagulant coating biological materials. Compared with an existing anticoagulant coating, the material surface anticoagulant coating based on the anticoagulant fusion protein HSA-Qinghaenin (c), provided by the invention, shows remarkable advantages. Through self-polymerization of polydopamine, the adhesiveness of the coating and a substrate material is greatly improved, and the stability and durability of the coating are ensured. HSA in the anticoagulant fusion protein HSA-Qinghaenin (c) can inhibit the adsorption of plasma proteins and platelets, the Qinghaenin (c) takes FXII in an endogenous blood coagulation pathway as a target spot, the activation of a blood coagulation factor is inhibited, meanwhile, the risk of inducing bleeding is avoided, and the HSA-Qinghaenin (c) can play a role of'one stone and two birds' in the aspect of anticoagulation of a biological material.

The present invention provides an anticoagulant reversal agent which is a compound having the structure represented by formula I, a salt thereof, or a deuterated thereof. Experimental results have shown that the compound according to the present invention can more effectively suppress hemorrhagic complications caused by anticoagulants such as warfarin, heparin, and enoxaparin sodium, and exhibits high efficacy over a broad spectrum.

Provided is a medicinal liquid supply device which is less constrained by a packaging material of a medicinal liquid such as heparin, and is capable of being used for multiple rounds of treatment using the medicinal liquid on a package by package basis. A medicinal liquid supply device is for supplying a medicinal liquid to a blood circuit included in a blood purification device for purifying blood, and comprises: a composition-holding part into which an anticoagulant housed in a container can be introduced from the container, and which holds a composition containing at least the introduced anticoagulant; and a linking part that links the composition-holding part to the blood circuit, and allows the composition to be guided out from the composition-holding part to the blood circuit.

The invention discloses a blood routine microsphere, a preparation method thereof and application of the blood routine microsphere in a vacuum blood collection tube, and belongs to the technical field of medical instruments. The blood routine microsphere is composed of ethylenediamine tetraacetic acid salt and an excipient, all the components are dissolved in deionized water to form a solution, the solution is rapidly frozen in liquid nitrogen through a bead dropping machine to form a microsphere precursor, and then the freeze-dried microsphere with the diameter of 2.0-6.0 mm is prepared through a vacuum freeze-drying process. The microspheres have the characteristics of uniform particle size, rapid dissolution and stable anticoagulation effect. The microspheres are applied to a vacuum blood collection tube. According to the invention, the production process of the traditional vacuum blood collection tube is simplified, the defects that the liquid anticoagulant is not uniformly sprayed and blood coagulation is easily caused are overcome, the product quality and the production efficiency are improved, and the production cost is reduced.

The invention relates to the field of medical health and intelligent optimization, and discloses a dialysis anticoagulation risk intelligent early warning method and system fused with multi-modal physiological signals, and the method comprises the steps: S1, synchronously collecting the multi-modal data of a patient in the dialysis process, and standardizing the multi-modal data into a unified time sequence matrix; s2, inputting the unified time sequence matrix into an anticoagulation risk prediction model, performing first-class feature extraction on continuous monitoring signals, performing second-class feature extraction on discrete detection signals, and extracting embedding features of patient individualization and treatment scene data; performing cross-modal fusion on the three types of extracted features to generate a fusion feature vector, and outputting a thrombus risk probability and a bleeding risk probability in a future preset time period; s3, when the risk probability exceeds the corresponding early warning threshold value, performing search optimization on the administration parameter of the current anticoagulant, and generating a dose adjustment instruction; and S4, executing the adjustment instruction, predicting the anti-coagulation risk again, and evaluating the regulation and control effect. Therefore, the safety and effectiveness of the hemodialysis process are remarkably improved.

The invention relates to the technical field of biomedical materials, in particular to an anticoagulation hemodialysis membrane, a base material of the anticoagulation hemodialysis membrane is polysulfone or polyethersulfone, the anticoagulation hemodialysis membrane is of a porous asymmetric structure, and the inner wall surface, making contact with blood, of the hemodialysis membrane is of a bionic micro-nano composite structure. The structure comprises micron-sized bulges and nano-sized particles distributed on the surfaces of the micron-sized bulges, a zwitterionic polymer is covalently grafted on the surface of the micro-nano composite structure and the inner wall of a membrane pore channel; heparin molecules are covalently bonded to the tail end of the zwitterionic polymer. According to the anticoagulant hemodialysis membrane, the anticoagulant performance is qualitatively improved while the excellent mechanical strength, solute clearance rate and ultrafiltration performance of a traditional polysulfone membrane are kept.

The invention relates to the technical field of medical instruments, in particular to a heparin coating based on material surface ammonification modification and a preparation method thereof, and the preparation method at least comprises the following steps: carrying out ultrasonic pretreatment on a base material with purified water, and drying for later use; the preparation method comprises the following steps: performing amination modification on a base material subjected to ultrasonic pretreatment by adopting an ammoniation reagent solution, and immersing the base material into a heparin solution to prepare the base material with a heparin coating on the surface. The surface of the material is subjected to amination modification by adopting a micromolecular ammoniation reagent and / or a macromolecular ammoniation reagent system, complex pretreatment such as plasma and ultraviolet rays does not need to be carried out on a base material, specific functional group activation does not need to be carried out on heparin, and the heparin is directly reacted after being subjected to ammoniation modification; the stable covalent grafted heparin anticoagulation coating can be formed, the anticoagulation time is prolonged, and the long-term implantation requirement is met.