56 results about "Anticoagulant" patented technology

The invention discloses an extraction method of leech anticoagulant protein, and belongs to the technical field of biological extraction.According to the extraction method, after components of induction liquid are optimized, mucous membranes are activated, and the living tissue environment naturally sucked by leeches is simulated, so that the leeches can be induced to better suck, the sucking amount of the leeches is guaranteed, and the anti-coagulation protein content of the leeches is improved; the leeches can be effectively stimulated to secrete more anticoagulant proteins with higher activity; meanwhile, under the coordination effect of the tranquilizer, the leech is kept in a warm state, so that the silent and relaxed physiological state of the leech can still be ensured in a dizziness stimulation or air pressure difference stimulation state, the loss of the living leech can be reduced, conditions for repeated extraction are provided for the leech, the gland secretion activity of the leech tends to be stable and vigorous, and the survival rate of the leech is increased. The extraction rate is further improved.

The utility model provides a prefilled anticoagulant temporary storage device which comprises a barrel body and opening and closing strips, a top cover is detachably arranged on the top of the barrel body, an installation block is arranged on the top of the top cover, a plurality of containing pipes are vertically arranged on the installation block in a penetrating mode, each containing pipe is communicated with the barrel body, and the opening and closing strips correspond to the containing pipes one to one. Each opening and closing strip is horizontally and slidably arranged on the mounting block in a penetrating mode, a strip-shaped groove allowing the opening and closing strip to be inserted is formed in the side wall of each containing pipe, and the problem that in the prior art, when medical staff recheck the type and dosage of the pre-filled anticoagulant, the risk that the medical staff are punctured by a needle head exists is solved.

The utility model relates to the technical field of medical instruments, in particular to a blood sampling test tube placing rack for outpatient nursing, which comprises a fixing frame, a rotating shaft, a placing frame, a small motor and the like. The left side and the right side of the top of the fixing frame are rotationally connected with at least three rotating shafts, a placing frame is connected between the left rotating shaft and the right rotating shaft, each placing frame is provided with at least five inserting holes allowing test tubes to be inserted, a small motor is installed on one side of the fixing frame, and an output shaft of the small motor is fixedly connected with the rotating shaft in the middle. Due to the arrangement of the placing frames, the rotating shaft, the transmission belt and the small motor, the placing frames rotate along the rotating shaft under the transmission action of the transmission belt, so that blood and an anticoagulant in a test tube are fully mixed, the effectiveness of blood sampling is ensured, manual shaking up is not needed, the mixing efficiency of the blood and the anticoagulant is improved, time can be saved, and the working efficiency is improved. And a fixing block, a clamping block and a connecting spring are further arranged, so that the clamping block can be clamped and fixed, and the test tube is prevented from being thrown out of the placing frame during rotation.

The invention belongs to the technical field of biology, and relates to an anticoagulant fusion protein HSA-Qinghaenin (c), a coding gene and application thereof, in particular to preparation of the anticoagulant fusion protein and application of the anticoagulant fusion protein in the fields of prevention of in-vivo thrombus formation and preparation of anticoagulant coating biological materials. Compared with an existing anticoagulant coating, the material surface anticoagulant coating based on the anticoagulant fusion protein HSA-Qinghaenin (c), provided by the invention, shows remarkable advantages. Through self-polymerization of polydopamine, the adhesiveness of the coating and a substrate material is greatly improved, and the stability and durability of the coating are ensured. HSA in the anticoagulant fusion protein HSA-Qinghaenin (c) can inhibit the adsorption of plasma proteins and platelets, the Qinghaenin (c) takes FXII in an endogenous blood coagulation pathway as a target spot, the activation of a blood coagulation factor is inhibited, meanwhile, the risk of inducing bleeding is avoided, and the HSA-Qinghaenin (c) can play a role of'one stone and two birds' in the aspect of anticoagulation of a biological material.

The present invention provides an anticoagulant reversal agent which is a compound having the structure represented by formula I, a salt thereof, or a deuterated thereof. Experimental results have shown that the compound according to the present invention can more effectively suppress hemorrhagic complications caused by anticoagulants such as warfarin, heparin, and enoxaparin sodium, and exhibits high efficacy over a broad spectrum.

The invention discloses a blood routine microsphere, a preparation method thereof and application of the blood routine microsphere in a vacuum blood collection tube, and belongs to the technical field of medical instruments. The blood routine microsphere is composed of ethylenediamine tetraacetic acid salt and an excipient, all the components are dissolved in deionized water to form a solution, the solution is rapidly frozen in liquid nitrogen through a bead dropping machine to form a microsphere precursor, and then the freeze-dried microsphere with the diameter of 2.0-6.0 mm is prepared through a vacuum freeze-drying process. The microspheres have the characteristics of uniform particle size, rapid dissolution and stable anticoagulation effect. The microspheres are applied to a vacuum blood collection tube. According to the invention, the production process of the traditional vacuum blood collection tube is simplified, the defects that the liquid anticoagulant is not uniformly sprayed and blood coagulation is easily caused are overcome, the product quality and the production efficiency are improved, and the production cost is reduced.

The invention relates to the field of medical health and intelligent optimization, and discloses a dialysis anticoagulation risk intelligent early warning method and system fused with multi-modal physiological signals, and the method comprises the steps: S1, synchronously collecting the multi-modal data of a patient in the dialysis process, and standardizing the multi-modal data into a unified time sequence matrix; s2, inputting the unified time sequence matrix into an anticoagulation risk prediction model, performing first-class feature extraction on continuous monitoring signals, performing second-class feature extraction on discrete detection signals, and extracting embedding features of patient individualization and treatment scene data; performing cross-modal fusion on the three types of extracted features to generate a fusion feature vector, and outputting a thrombus risk probability and a bleeding risk probability in a future preset time period; s3, when the risk probability exceeds the corresponding early warning threshold value, performing search optimization on the administration parameter of the current anticoagulant, and generating a dose adjustment instruction; and S4, executing the adjustment instruction, predicting the anti-coagulation risk again, and evaluating the regulation and control effect. Therefore, the safety and effectiveness of the hemodialysis process are remarkably improved.

The invention relates to the technical field of biomedical materials, in particular to an anticoagulation hemodialysis membrane, a base material of the anticoagulation hemodialysis membrane is polysulfone or polyethersulfone, the anticoagulation hemodialysis membrane is of a porous asymmetric structure, and the inner wall surface, making contact with blood, of the hemodialysis membrane is of a bionic micro-nano composite structure. The structure comprises micron-sized bulges and nano-sized particles distributed on the surfaces of the micron-sized bulges, a zwitterionic polymer is covalently grafted on the surface of the micro-nano composite structure and the inner wall of a membrane pore channel; heparin molecules are covalently bonded to the tail end of the zwitterionic polymer. According to the anticoagulant hemodialysis membrane, the anticoagulant performance is qualitatively improved while the excellent mechanical strength, solute clearance rate and ultrafiltration performance of a traditional polysulfone membrane are kept.

The invention relates to the technical field of medical instruments, in particular to a heparin coating based on material surface ammonification modification and a preparation method thereof, and the preparation method at least comprises the following steps: carrying out ultrasonic pretreatment on a base material with purified water, and drying for later use; the preparation method comprises the following steps: performing amination modification on a base material subjected to ultrasonic pretreatment by adopting an ammoniation reagent solution, and immersing the base material into a heparin solution to prepare the base material with a heparin coating on the surface. The surface of the material is subjected to amination modification by adopting a micromolecular ammoniation reagent and / or a macromolecular ammoniation reagent system, complex pretreatment such as plasma and ultraviolet rays does not need to be carried out on a base material, specific functional group activation does not need to be carried out on heparin, and the heparin is directly reacted after being subjected to ammoniation modification; the stable covalent grafted heparin anticoagulation coating can be formed, the anticoagulation time is prolonged, and the long-term implantation requirement is met.

The invention belongs to biomedical materials, and particularly relates to an anticoagulant coating material for a blood contact material and application of the anticoagulant coating material. The anticoagulant coating material comprises a bottom coating material and a top coating material which are independently packaged; the bottom layer coating material is prepared by crosslinking an amino compound and a silane coupling agent, the amino compound and the silane coupling agent are subjected to a grafting reaction, and the bottom layer coating material contains an uncrosslinked amino compound; the top coating material comprises a bionic hydrophilic anticoagulant and a reducing agent, and the bionic hydrophilic anticoagulant is a phosphate compound. An anticoagulant coating formed on the surface of a blood contact material by the anticoagulant coating material provided by the invention has excellent hydrophilic performance and relatively low dynamic and static hemolysis rates, which shows that the anticoagulant coating material has excellent anticoagulant performance.

The utility model relates to the technical field of medical instruments, in particular to an EDTA (Ethylene Diamine Tetraacetic Acid) anticoagulation tube which comprises a tube body and a tube cover screwed at the open end of the tube body, a buckle is arranged on the outer wall of the pipe cover, a convex ring is formed at the open end of the pipe body, and the buckle is clamped with the convex ring after the pipe cover is in threaded connection with the pipe body, so that the pipe cover is limited to be separated from the pipe body in the axial direction of the pipe body; an anticoagulant is added into the tube body; according to the anti-freezing tube, the tube cover buckle and the tube body convex ring form axial limiting clamping connection, a double-locking mechanism is formed by matching threaded connection, even if threads are slightly loosened, the buckle can still prevent the tube cover from being separated from the tube body, and the problem of sample leakage caused by loose threaded connection of a traditional anti-freezing tube is fundamentally solved; and the safety of the blood sample in the collection, transportation and storage processes is ensured.

The invention discloses a portable hemodialysis instrument capable of preventing a loop from being blocked, and relates to the technical field of hemodialysis instruments. The blood pumping device comprises a shell, a reciprocating driving mechanism is arranged in the shell, a piston film is fixedly installed in a loop cavity in the shell, the reciprocating driving mechanism drives the piston film to reciprocate for blood pumping operation, and a sealing cover is fixedly installed at the end of the shell. According to the device, blood enters extracorporeal circulation through the connecting end, the flow monitoring mechanism monitors the blood flow of the blood inlet end and the blood return end in real time, when it is detected that the flow of the blood inlet end is obviously lower than the flow of the blood return end, it is indicated that thrombus is possibly formed or blockage is likely to happen in a loop, and at the moment, the anti-coagulation and anti-blocking mechanism is immediately started; the blood inlet pipeline is accurately filled with anticoagulant, initial thrombus is actively dissolved, and blockage expansion is prevented, so that manual shutdown cleaning in the background technology is avoided, dialysis continuity and safety are guaranteed, and one-way flowing of blood is guaranteed through the one-way valves on the two connecting ends.

The invention discloses a method for efficiently detecting trace residues of'three-high 'drugs in fish plasma, the'three-high' drugs comprise triamterene, terazosin, rosiglitazone, lovastatin, benazepril, pitavastatin and repaglinide, and the method comprises the following steps: adding an anticoagulant into a collected fish plasma sample, centrifuging, taking supernate, and collecting the supernate; the method comprises the following steps: firstly, adding an internal standard solution, adding acetone containing formic acid with the volume fraction of 1% into a purification tube, loading a labeled sample, pressurizing to ensure that the sample drips in a drop shape, collecting by using a polypropylene test tube containing a purification reagent, oscillating and purifying, centrifuging, taking supernate, and concentrating to obtain a concentrated solution; the method disclosed by the invention is high in sensitivity, and the detection limit range of seven kinds of drugs for target'three highs' in the blood plasma of the aquatic environment fish is 0.02-0.25 ng / mL.

A pharmaceutical composition comprising glutathione disulfide or pharmaceutically acceptable organic or inorganic salts thereof and glutathione disulfide S-oxide of the structure (I) or pharmaceutically acceptable organic or inorganic salts thereof for eliminating dose-related toxicity of pharmacologically active compounds and enhancing therapeutic activity of pharmacologically active compounds in the treatment of infectious and non-infectious diseases. Typically, the composition contains 0.01-10% of glutathione disulfide S-oxide by weight of the total composition, in addition to a metal (Me) in the form of a complexing compound containing Me-S-glutathione bond, said metal being selected from platinum group elements, typically platinum. The amount of d-metal complexing compound administered to a patient can be 10 ‑3 to 10 ‑15 mol / kg of body weight. The composition can be used in combination with pharmacologically active compounds, which are anticoagulants, factor Xa inhibitors, antibacterial or antiviral agents, to increase their therapeutic activity and eliminate dose-related toxicity.

This invention relates to the field of in vitro culture and antigen preparation technology, and discloses an antibiotic-free culture medium and a method for preparing autologous whole blood antigen. The culture medium is a liquid culture medium with a pH of 7.2-7.4, composed of a basic nutrient system, an activation and stimulation system, a stable anticoagulant system, and a virus and bacteria support system, with the remainder being water for injection. This invention constructs a composite culture system comprising a basic nutrient system, an activation and stimulation system, a stable anticoagulant system, and a virus and bacteria support system, enabling the culture medium to simultaneously meet the survival and activation needs of endogenous microorganisms and immune cells within the same system. It achieves synergistic support for both biological systems, thereby completing the culture process without separating whole blood components, and providing a stable environment for obtaining autologous whole blood antigen.

The invention discloses an animal epidemic disease sampling detection device, and relates to the technical field of animal epidemic disease detection, the animal epidemic disease sampling detection device comprises a box body and a box cover hinged on the box body, a sealing plate is arranged in the box body, the sealing plate divides the box body into an activity chamber and a heat preservation chamber, a test tube storage rack is arranged in the box body, and the test tube storage rack is located in the heat preservation chamber; the test tube storage rack comprises a placement plate, a bottom plate, a vertical rod, two test tube fixing assemblies and a transmission mechanism used for driving the test tube fixing assemblies to rotate. Through cooperation of the transmission mechanism and the test tube fixing assembly, all test tubes can uniformly and stably rotate, sample blood and an anticoagulant can be fully mixed, and in the rotation process of the test tubes, the outer walls of the test tubes and constant-temperature gas in the heat preservation chamber are subjected to heat exchange, so that the stability of the test tubes is improved. It is ensured that the blood sample in the test tube is maintained within a proper temperature range, blood sample deterioration or detection result deviation caused by temperature changes is avoided, and the accuracy and reliability of the detection result are ensured.

The present application relates to the technical field of medical noble metal materials and medical devices, and in particular to a gold surface anti-coagulation coating structure, a preparation method and application thereof.The present application uses chloroauric acid to construct a micro-nano morphology surface in situ by wet chemical reduction on the surface of a gold layer, uses fluorothiol to modify the surface of the micro-nano gold layer, and injects a lubricant into the modified micro-nano gold surface to construct a lubricant-injected porous self-lubricating surface (SLIPS).The locking ability of the nano gold layer surface modified by fluorothiol is significantly improved, so that the lubricating layer is not prone to loss, thereby having a long-lasting anti-coagulation function.The present application solves the problem that the injected lubricating liquid is prone to depletion and the anti-coagulation performance has poor durability when a liquid injection surface method is used to perform anti-coagulation treatment on the surface of a material.

The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material; immersing the treated valve material in a blocking solution containing an amine compound for 0.5-6 h, thereby blocking the remaining aldehyde groups after glutaraldehyde cross-linking; then placing the valve material into a reaction solution containing an anticoagulant and a cross-linking agent, and performing cross-linking treatment for 6-24 h at 4° C.-37° C.; and finally washing and obtaining the valve material, and storing the valve material in a mixed solvent of glutaraldehyde or isopropyl alcohol / glycerol. The method can effectively solve the problem of calcification and thrombosis caused by residual aldehyde groups in a valve material prepared by the existing method. The valve material prepared by the present method can be used as a valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.

This invention relates to a heparin anticoagulant oligosaccharide with low thrombocytopenia-inducing activity, its preparation method, and its application, belonging to the field of biomedical technology. The heparin anticoagulant oligosaccharide with low thrombocytopenia-inducing activity comprises an AT-binding sequence and a -GlcNS(6S)-GlcA2S- or -GlcNS(6S)-IdoA2S- linker sequence, specifically heparin anticoagulant dodecanosaccharide 12I-2, heparin anticoagulant dodecanosaccharide 12G-1, or heparin anticoagulant dodecanosaccharide 12G-2. This invention also provides methods for preparing heparin anticoagulant dodecanosaccharides 12I-2, 12G-1, and 12G-2, and their applications in the preparation of safe and effective anticoagulant and antithrombotic drugs. The heparin anticoagulant oligosaccharide designed in this invention is a specific dodecanoic acid molecule. By optimizing its sugar chain length, key structural domains and spatial conformation, its ability to form pathogenic H / PF4 complexes with platelet factor 4 (PF4) is weakened to the greatest extent. In clinical anticoagulation applications, it has a significant safety advantage in reducing the incidence of HIT and related fatal thrombosis (HITT).

The invention provides a novel composition and method for preserving biological fluid samples. The composition comprising: (1a) a boron cluster compound of formula [B 12X 12] 2-, or salt thereof; (1b) optionally an anticoagulant; and (1c) optionally a solvent selected from the group consisting of water, dimethylsulfoxide, methanol, ethanol, and isopropanol.

The present application relates to the technical field of pharmaceutical preparations, in particular to a kind of lenvatinib mesylate capsule and preparation method thereof.In order to overcome the dissolution problem of lenvatinib mesylate capsule, the present application is granulated by using aqueous solution of alkaline anticoagulant and the water addition amount in the granulation process is controlled, which can increase the particle size of the granules, thereby increasing the flowability of the granules, which is beneficial to industrial production, and on the other hand, it can improve the dissolution of lenvatinib mesylate capsule and thereby improve the bioavailability.The lenvatinib mesylate capsule prepared by the method of the present application has high dissolution rate, the product quality is more controllable, and the preparation process is simple and suitable for industrial production.

The utility model discloses a kit for detecting the concentration of anticoagulant drug in plasma, which comprises a kit body and a reagent shelf arranged in the kit body, the reagent shelf is matched with the internal volume of the kit body so as to be used for accommodating an extract liquor container, a quality control container and a calibrator container, and the reagent shelf comprises a guide layer and a lower limiting layer, the upper limiting layer is arranged between the lower limiting layer and the guide layer, the guide layer is provided with an extraction liquid container guide hole, a quality control product container guide hole and a calibration product container guide hole, and the lower limiting layer and the upper limiting layer are respectively provided with a lower limiting hole and an upper limiting hole; a side wall accommodating groove is formed in one side, facing the side wall of the box body, of the side wall of the reagent rack. When the kit for detecting the concentration of the anticoagulant drug in the plasma is used, the reagent rack is integrally taken out, each container does not need to be independently taken out from the reagent rack, the risks of confusion and possible overturning are avoided, the lower limiting holes and the upper limiting holes play a role in limiting and fixing the containers, the transportation is convenient, and the cost is reduced. And built-in non-container articles such as the specification are not easy to lose.

The invention relates to a predonation bag system comprising a predonation bag to be filled with whole blood during the blood removal. an anticoagulant being added to the whole blood in the predonation bag and sample containers being automatedly filled with the whole blood from the predonation bag only in the laboratory for blood analysis. The predonation bag system is part of a blood bag system. The invention also relates to corresponding method for removing blood by means of the predonation bag system and for analyzing the whole blood of each donor.

The invention relates to an artificial intelligence device for acquiring health data, in particular to the field of medical artificial intelligence, realizes personalized and dynamic treatment optimization of deep venous thrombosis of lower limbs of a cerebral apoplexy patient by fusing deep reinforcement learning and human expert knowledge, and can analyze physiological state changes of the patient in real time, so that the system can be used for treating cerebral apoplexy. The dosage of the anticoagulant drug is automatically adjusted, insufficient or excessive treatment risks are avoided, treatment safety and effectiveness are remarkably improved, meanwhile, data redundancy is reduced through intelligent feature screening, model interpretability is enhanced, clinicians can understand and adopt AI decisions more easily, in the high-risk situation, the system is preferentially combined with expert experience, decision reliability is ensured, and the accuracy of the AI decisions is improved. Therefore, the survival rate of patients and the thrombus prevention effect are improved, and the medical quality and prognosis level are integrally improved.

The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a puncture-preventing venous blood taking needle. The puncture-preventing venous blood taking needle comprises a blood taking needle body, a blood injection needle body, a hose and a puncture-preventing mechanism, the blood taking needle body comprises a blood taking needle head, a blood taking needle head seat and a blood taking needle wing; the blood injection needle body comprises a blood injection needle head, a blood injection needle head seat and two elastic pressing pieces; the puncture-preventing mechanism comprises a first protection assembly and a second protection assembly which are arranged on the blood taking needle head seat and the blood injection needle head seat respectively. When the blood taking amount in the blood taking tube reaches the required blood amount, the blood in the hose is cut off by pressing the two elastic pressing pieces, blood continues to enter the blood taking tube is prevented, the blood taking amount in the blood taking tube and the proportion of the coagulant or the anticoagulant in the blood taking tube are correct, and when the blood injection needle body is separated from the blood taking tube, the hose is pressed by the two elastic pressing pieces, blood dripping from the blood injection needle head to contaminate the hands of medical staff or the operation table top is prevented.

The application discloses a blood sampling and detection card integrated device, relates to the technical field of blood sampling, and comprises a blood sampling needle and a detection card main body. One end of the blood sampling needle is provided with a hose, and one end of the hose is provided with a vacuum blood storage tube. A serum treatment tube is arranged at the bottom of the vacuum blood storage tube. A connecting assembly for quickly guiding blood is arranged between the vacuum blood storage tube and the serum treatment tube, and the connecting assembly comprises an inner clamping groove and an outer clamping plate. The outer clamping plate is slidably arranged in the inner clamping groove. The blood sampling and detection card integrated device can prevent blood coagulation through the anticoagulant in the built-in groove of the vacuum blood storage tube. The blood filtering film gasket treated by the anti-red blood cell antibody in the serum treatment tube can effectively filter red blood cells, obtain pure serum, avoid red blood cell interference on the detection result, and prevent blood or serum leakage and reduce the risk of cross contamination in the initial state through the close combination of the sealing gasket plate and the built-in groove and the sealing design of the aluminum foil.

The application discloses a hemoglobin analysis anticoagulant sample agglutination detection equipment, and relates to the technical field of biomedical detection, which comprises a casing, a blood collection tube and a machine cover rotatably installed on the casing, a plurality of laser receiving plates rotatably installed on the machine cover and a light blocking cylinder fixedly installed in the casing; a support is installed in the casing through a damping support, a motor is fixedly installed on the support, a rotating disc is rotatably installed on the support, an object placing disc is fixedly installed on the rotating disc, and a plurality of tube rack stations for storing the blood collection tubes are installed on the object placing disc. The application has the advantages that the centrifugal light transmittance is used to detect the agglutination condition of the blood sample, a plurality of batches of samples can be detected at a time, the detection efficiency is higher, the detection has higher real-time performance, the detection result is more accurate, the level position of the agglutination can be judged, and the type of the agglutination can be judged according to the agglutination position.