30results about How to "Long-acting sustained release" patented technology

The invention relates to a liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material and a preparation method thereof. The composite material is a compound of doxorubicin (doxorubicin) and a lactobionic acid modified multi-walled carbon nanotube CNT-PEI-FI-PEG-LA. The preparation method comprises the following steps: synthesizing the multi-walled carbon nanotube composite material CNT-PEI-FI-PEG-LA; formulating doxorubicin standard curves in two types of pH value environments; and dissolving the multi-walled carbon nanotube composite material in water, adding a doxorubicin hydrochloride aqueous solution, adjusting the pH value to neutrality and alkalinity, stirring for 4 hours, dialyzing, and carrying out freeze drying, thus obtaining the liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material. The liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material has the characteristics of pH sensitive release and liver cancer cell targeting, can be used for anti-tumor research and has very high practical value.

The invention belongs to the technical field of medicines and specifically relates to monosialotetrahexosyl ganglioside sodium for injection and a preparation method thereof. The monosialotetrahexosyl ganglioside sodium for injection provided in the invention contains GM1, gelatin and PLGA (Polylacticcoglycollic Acid). A microsphere injection prepared from the monosialotetrahexosyl ganglioside sodium for injection provided by the invention is good in reproducibility and encapsulation ratio; the drug-loading rate is improved; the drug release is continuous and stable; the dosage at a time is obviously reduced and the foreign body sensation is reduced; effective blood concentration can be maintained for a long time; the shortcoming of administration every day is avoided; the life quality of a patient is improved; and the problem of the fluctuation of the blood concentration caused by the conventional preparations is solved.

The present invention relates to a tranexamic acid flexible liposome for whitening and removing freckles and its preparation method and application. ~12.0% phospholipids, 0.5%~5.0% cholesterol, 0.05%~1% membrane softener, 0.05%~1.0% ceramide, 0.5%~3.0% emollient, 5.0%~15.0% polyol, 0.5%~2.0 % antioxidants and the balance of purified water. The active ingredients in the tranexamic acid flexible liposome prepared by the present invention have complementary functions and can play a synergistic effect; the drug loading capacity is large, and active ingredients with different functions such as tranexamic acid can be transported to the deep layer of the skin to play a long-term effect. It improves the cumulative penetration and retention of tranexamic acid cream, improves the defects of oral administration of gastrointestinal adverse reactions, improves compliance, and is easy for patients to accept.

The invention discloses a PEG-PCL-PEG triblock copolymer modified madecassoside (MA) liposome and application thereof, belonging to the fields of pharmaceutical preparations, skin care products and daily chemical products. The MA liposome is prepared from the following components: a PEG-PCL-PEG triblock polymer, MA, cholesterol and lipid, wherein the MA is encapsulated in a liposome. The MA liposome is modified by the PEG-PCL-PEG triblock polymer, so that the fitting effect of a drug and the skin can be improved; especially, when being applied to the skin, the PEG-PCL-PEG triblock copolymer modified MA liposome can be converted into cream from liquid, thus achieving an effect of drug storage; therefore, the time of action between the MA and the skin is prolonged, the effect of long-actingslow release is realized, and the treatment effect is enhanced. A preparation method provided by the invention is simple in technology and easy to amplify; the PEG-PCL-PEG triblock copolymer modifiedMA liposome has wide application prospects in the aspects of later large-scale medical production and potential medical use.

The invention relates to a liver cancer-targeted graphene oxide drug-loaded composite material and a preparation method thereof. The composite material is a composite of doxorubicin DOX and lactobionic acid-modified graphene oxide GO-PEI-FI-PEG-LA things. Preparation: synthesis of graphene oxide composite material GO‑PEI‑FI‑PEG‑LA; preparation of doxorubicin standard curves in two pH environments; dissolving graphene oxide composite material in water, adding doxorubicin hydrochloride aqueous solution, And adjust the pH value to neutral alkaline, stir for 4 hours, dialyze, and freeze-dry to obtain the product; the new drug-loaded material of the present invention has the characteristics of pH-sensitive release and liver cancer cell targeting, and can be used for anti-tumor research, and has great advantages. Good practical value.

The invention discloses a plaster for treatment of mastopathy. The plaster is composed of: Dragon's blood, borax, chidan, pangolin sheet, frankincense, gardenia, oak bark, minium, borneol, Zanthoxylum nitidum, Aconitum kusnezoffii and sesame oil. The preparation method of the plaster includes: crushing the Chinese herbal medicines into fine powder except for gardenia and minium, squeezing the gardenia with sesame oil and then getting it out, adding minium and the Chinese herbal medicinal fine powder, conducting stirring and cooling, coating non-woven fabrics with the mixture and performing cutting into required specifications. The plaster provided by the invention has the targeted therapy effect of transporting active medicinal ingredients directly to breast hyperplasia tissue lesions, can slowly release medicinal active substances for a long time, and has the advantages of convenient and comfortable use, no irritation to skin, no allergy and the like, thus being an ideal drug for treating hyperplasia of mammary glands.

The invention relates to a boron drug-carrying system modified by RGD peptide and its preparation and application. The boron composite material modified by RGD peptide is used as a drug carrier to load drugs. The experimental conditions of the present invention are easy to control and simple to operate; the obtained drug-loaded complex has good biocompatibility, can be long-acting and sustained release, and has dual sensitive drug release properties of pH and near-infrared light (NIR). Value and high release rate under near-infrared light irradiation environment, suitable for the microenvironment of tumor tissue, can be used for the synergistic effect of combined low-temperature photothermal therapy and chemotherapy, and has application prospects in the preparation of tumor targeting, imaging and synergistic therapeutic drugs.

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.