30results about How to "Long-acting sustained release" patented technology

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

The invention discloses an epirubicin loaded graphene quantum dot drug carrying system and a preparation method thereof. The preparation method includes the following steps: preparation of graphene quantum dots by a hydrothermal method; loading an anti-cancer drug with the graphene quantum dots; and performing a drug slow-release experiment, and performing a cytotoxicity test on the drug carrying system. The graphene quantum dots prepared by the hydrothermal method are used as a drug carrier for being loaded with epirubicin, greatly improve the drug loading rate, and show a quite good inhibitory effect on tumor HeLa cells. The preparation method of the drug carrying system is simple to operate, mild in reaction conditions and high in drug loading rate, and is expected to have a broad application prospect in the field of biological medicine.

The invention relates to a liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material and a preparation method thereof. The composite material is a compound of doxorubicin (doxorubicin) and a lactobionic acid modified multi-walled carbon nanotube CNT-PEI-FI-PEG-LA. The preparation method comprises the following steps: synthesizing the multi-walled carbon nanotube composite material CNT-PEI-FI-PEG-LA; formulating doxorubicin standard curves in two types of pH value environments; and dissolving the multi-walled carbon nanotube composite material in water, adding a doxorubicin hydrochloride aqueous solution, adjusting the pH value to neutrality and alkalinity, stirring for 4 hours, dialyzing, and carrying out freeze drying, thus obtaining the liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material. The liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material has the characteristics of pH sensitive release and liver cancer cell targeting, can be used for anti-tumor research and has very high practical value.

The invention discloses a method for preparing a nanometer iron citrate liposome. The method comprises the following steps: 1, weighing soybean lecithin and cholesterol according to a certain mass ratio, dissolving soybean lecithin and cholesterol in anhydrous ethanol, and using a PBS buffer solution to prepare an iron citrate solution; 2, taking a certain volume of the iron citrate solution into a beaker, placing in a 40-60DEG C water bath, adding the above obtained soybean lecithin and cholesterol suspension in a dropwise manner while stirring, continuously stirring after the dropwise addition until ethanol completely volatilizes, carrying out water-bath ultrasonic treatment on the above obtained liposome suspension for 5-30min to obtain a creamy yellow semitransparent liposome suspension, carrying out photophobic dialysis for 4-5h, filtering by a filter membrane, placing in a brown bottle, and preserving at 4DEG C. The nanometer iron citrate liposome obtained in the invention has the advantages of structured and uniform particle size, good stability, high entrapment rate, and long-acting slow releasing effect, is used for the iron supplementation of the brains of rats through intranasal administration, and has an obviously better effect than iron citrate unentrapped by the liposome.

The invention relates to an RGD peptide modified boron drug loading system, preparation thereof and an application of the system. An RGD peptide modified boron composite material serves as a drug carrier for loading drugs. Experimental conditions are easily controlled, operation is simple, and an obtained drug loading compound has good biocompatibility, can be slowly released in a sustained manner, has pH (potential of hydrogen) and NIR (near-infrared light) double sensitive drug releasing properties, is high in release rate in low-pH value and near-infrared light irradiation environments andsuitable for microenvironments of tumor tissues, can be used for achieving synergistic effects of low-temperature photothermal therapy and chemotherapy and has application prospects in preparation oftumor targeted, imaging and synergistic therapy drugs.

The hydrophilic plaster for treating dysmenorrheal consists of indometacin 0.15-6 wt%, salbutamol 0.01-3 wt%, transdermal promoter 0.5- 10 wt%, humectant 5-40 wt%, hydrophilic polymer material 4-20 wt%, cross-linking agent 0.1-3 wt%, and cross-linking regulator 0.01-2 wt%, and is prepared through common plaster preparing process. Compared with traditional preparation, the present invention contains no organic solvent, and has high safety, reduced toxic side effect and other advantages.

The invention discloses a preparation method of a purple cabbage anthocyanin-collagen chitosan composite intelligent film. The preparation method comprises the following steps: preparing purple cabbage anthocyanin powder from purple cabbage; then adding chitosan into an acetic acid aqueous solution, adding a collagen aqueous solution, continuously adding glycerol and sodium citrate, heating and stirring the mixture in a water bath, and cooling the mixture to obtain a collagen chitosan solution; and adding the purple cabbage anthocyanin powder into the collagen chitosan solution, uniformly stirring the solution, performing standing foaming treatment, injecting the obtained mixed solution into a mold, and drying the solution to obtain the purple cabbage anthocyanin-collagen chitosan composite membrane. The purple cabbage anthocyanin-collagen chitosan composite intelligent film can be applied to freshness indication and fresh-keeping storage of fresh products.

The invention relates to a liposome preparation for blackening hair and a preparation method of the liposome preparation. The liposome preparation is prepared from melanin, trace elements, protein polypeptide components for recovering normal metabolism of melanin, nucleic acid components for enhancing or repairing hair follicle genes, antioxidant related genes and/or cytokines beneficial to hair follicle health and the like efficiently. Functional biomacromolecules such as protein DNA are encapsulated by adopting liposome, so that the transdermal absorption efficiency can be greatly improved,normal metabolism of hair follicle melanin is effectively promoted, the scalp hair follicle health is maintained, and the blackening of white hair is promoted. Effective components, especially biomacromolecules, are wrapped by lipidosome, so that the transdermal absorption effect and the normal-temperature storage stability are greatly improved, the effective components can be accumulated on the epidermal layer of the skin, a long-acting slow-release effect is achieved, the local drug concentration is increased, and the treatment effect is enhanced. The liposome is similar to natural microcapsules in a human body in size and structure, has the characteristic of hair follicle affinity, targets hair follicles, and has the effects of promoting hair blacking and maintaining scalp health.

The invention provides hydrogel with ROS response and a preparation method and application thereof, during preparation, carbodiimide is used as a catalyst, catechol groups are grafted on chitosan macromolecules, and solubility and adhesion of chitosan are improved. Cystamine is used as a cross-linking agent, and amino of cystamine and benzoquinone formed after catechol groups are oxidized are subjected to Michael addition reaction to form a cross-linked network, so that the hydrogel is formed. The invention further discloses the hydrogel with ROS response prepared by the method and application of the hydrogel. The disulfide bond contained in cystamine can be broken and converted into sulfinic acid under the action of active oxygen, so that the structure of the hydrogel is destroyed, the hydrogel can play an intelligent drug release role in an atherosclerosis site where more active oxygen substances are generated, burst release of the drug in a diseased region is avoided, and risks of restenosis in blood vessels, delayed healing of endothelium, advanced thrombus and the like are expected to be reduced.

The invention discloses a preparation method and application of reduced glutathione lipidosome, relates to a preparation method and application of lipidosome, and aims at solving the technical problem of low inclusion rate of the lipidosome prepared by the existing method. The method comprises the following steps: 1, weighing soya bean lecithin and fatty acid glycerides, dissolving into absolute ethyl alcohol, and heating in a water bath to prepare an oil phase; 2, weighing reduced glutathione and a surfactant to be dissolved into distilled water, and heating in the water bath to prepare a water phase; 3, mixing the prepared oil phase with the water phase, emulsifying, carrying out vacuum rotary evaporation to remove absolute ethyl alcohol, adding distilled water, pre-cooling after ice-bath, and then carrying out freeze drying to obtain lipidosome powder. The reduced glutathione lipidosome disclosed by the invention is applied to intravenous injection, oral medication, transdermal drug delivery, and a drug delivery system for the lung and eyes. The encapsulation efficiency of the reduced glutathione lipidosome disclosed by the invention is 68.15%+/-1.53%. The preparation method is applied to the field of preparation of the lipidosome.

The invention discloses a tobramycin liposome used for aerosol inhalation. The tobramycin liposome used for aerosol inhalation is composed of the following components: 0.1%-15.0% of tobramycin, 0.5%-36.0% of a phospholipid, 0.05%-20.0% of a stabilizer, 0.01%-10.0% of a charge modifier, 0.01%-5.0% of an antioxidant, 5.0%-50.0% of an organic-phase medium and the balance an aqueous-phase medium. According to the tobramycin liposome used for aerosol inhalation, the aerosol inhalation technology is used, relative to oral administration, the aerosol inhalation technology has the advantages that a medicine can be directly delivered to a respiratory tract, is absorbed fast, and takes effect quickly, and a medicine concentration of the respiratory tract is increased; the bioavailability and the stability are high, and the tobramycin liposome used for aerosol inhalation has good safety; and a production process is simple, easy and reasonable, and the performance is stable, so that conditions arecreated for achieving industrial productization.

The invention relates to a novel straw direct gasification polygeneration preparation process, comprising a gasification furnace, a feeding device, a material pushing device, a material pressing device, a material homogenizing device, a carbon discharging device, a washing device, a fan, a water seal filtering device, a gas holder and a control cabinet. By virtue of the feeding device, the material pushing device, a material pressing device and a material homogenizing device, straw requiring no processing is directly fed into a gasification furnace to be gasified, the straw is effectively controlled to polygenerate straw carbon and straw gas, a carbon scraping grate and the carbon discharging device are combined to collect the straw carbon, labyrinth type spraying washing is carried out to separate the straw gas and straw extract, the water seal filtering device filters and collects the straw gas, and the device has high reliability, good safety performance, strong practicability, simple gasification process, good gasification effect, high straw utilization rate and low operation cost.

The invention relates to a high-tower compound fertilizer. The high-tower compound fertilizer contains a laver extract, industrial monoammonium, potassium sulfate, urea, monopotassium phosphate and amino acid chelated calcium. The high-tower compound fertilizer provided by the invention is friendly to the soil environment, has long-acting slow release property, can remarkably promote the root growth of crops on one hand, and can provide the stress resistance of the crops on the other hand.