30results about How to "Long-acting sustained release" patented technology

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

The invention discloses an epirubicin loaded graphene quantum dot drug carrying system and a preparation method thereof. The preparation method includes the following steps: preparation of graphene quantum dots by a hydrothermal method; loading an anti-cancer drug with the graphene quantum dots; and performing a drug slow-release experiment, and performing a cytotoxicity test on the drug carrying system. The graphene quantum dots prepared by the hydrothermal method are used as a drug carrier for being loaded with epirubicin, greatly improve the drug loading rate, and show a quite good inhibitory effect on tumor HeLa cells. The preparation method of the drug carrying system is simple to operate, mild in reaction conditions and high in drug loading rate, and is expected to have a broad application prospect in the field of biological medicine.

The invention relates to a liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material and a preparation method thereof. The composite material is a compound of doxorubicin (doxorubicin) and a lactobionic acid modified multi-walled carbon nanotube CNT-PEI-FI-PEG-LA. The preparation method comprises the following steps: synthesizing the multi-walled carbon nanotube composite material CNT-PEI-FI-PEG-LA; formulating doxorubicin standard curves in two types of pH value environments; and dissolving the multi-walled carbon nanotube composite material in water, adding a doxorubicin hydrochloride aqueous solution, adjusting the pH value to neutrality and alkalinity, stirring for 4 hours, dialyzing, and carrying out freeze drying, thus obtaining the liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material. The liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material has the characteristics of pH sensitive release and liver cancer cell targeting, can be used for anti-tumor research and has very high practical value.

The invention relates to a flexible tranexamic acid liposome with effects of whitening and removing freckles as well as a preparation method and application of the flexible tranexamic acid liposome. The flexible tranexamic acid liposome with effects of whitening and removing freckles is composed of the following components in percentage by mass: 0.1-6.0% of tranexamic acid, 1.0-12.0% of phospholipid, 0.5-5.0% of cholesterol, 0.05-1% of a membrane softener, 0.05-1.0% of ceramide, 0.5-3.0% of an emollient, 5.0-15.0% of polyhydric alcohols, 0.5-2.0% of an antioxidant and the balance of purified water. According to the flexible tranexamic acid liposome prepared in the invention, the various active ingredients realize functional complementation and can achieve synergistic effects; the drug loading capacity is high, the active ingredients with different effects, such as the tranexamic acid and the like, can be delivered to deep positions of the skin, and a long-term sustained release effectis achieved; and the accumulated transmission amount and retention volume of tranexamic acid cream are increased, the defect that an adverse reaction to the gastrointestinal tract is caused by oral medication is overcome, the compliance is improved, and the liposome is easily accepted by patients.

The invention discloses a method for preparing a nanometer iron citrate liposome. The method comprises the following steps: 1, weighing soybean lecithin and cholesterol according to a certain mass ratio, dissolving soybean lecithin and cholesterol in anhydrous ethanol, and using a PBS buffer solution to prepare an iron citrate solution; 2, taking a certain volume of the iron citrate solution into a beaker, placing in a 40-60DEG C water bath, adding the above obtained soybean lecithin and cholesterol suspension in a dropwise manner while stirring, continuously stirring after the dropwise addition until ethanol completely volatilizes, carrying out water-bath ultrasonic treatment on the above obtained liposome suspension for 5-30min to obtain a creamy yellow semitransparent liposome suspension, carrying out photophobic dialysis for 4-5h, filtering by a filter membrane, placing in a brown bottle, and preserving at 4DEG C. The nanometer iron citrate liposome obtained in the invention has the advantages of structured and uniform particle size, good stability, high entrapment rate, and long-acting slow releasing effect, is used for the iron supplementation of the brains of rats through intranasal administration, and has an obviously better effect than iron citrate unentrapped by the liposome.

The invention relates to an RGD peptide modified boron drug loading system, preparation thereof and an application of the system. An RGD peptide modified boron composite material serves as a drug carrier for loading drugs. Experimental conditions are easily controlled, operation is simple, and an obtained drug loading compound has good biocompatibility, can be slowly released in a sustained manner, has pH (potential of hydrogen) and NIR (near-infrared light) double sensitive drug releasing properties, is high in release rate in low-pH value and near-infrared light irradiation environments andsuitable for microenvironments of tumor tissues, can be used for achieving synergistic effects of low-temperature photothermal therapy and chemotherapy and has application prospects in preparation oftumor targeted, imaging and synergistic therapy drugs.

The hydrophilic plaster for treating dysmenorrheal consists of indometacin 0.15-6 wt%, salbutamol 0.01-3 wt%, transdermal promoter 0.5- 10 wt%, humectant 5-40 wt%, hydrophilic polymer material 4-20 wt%, cross-linking agent 0.1-3 wt%, and cross-linking regulator 0.01-2 wt%, and is prepared through common plaster preparing process. Compared with traditional preparation, the present invention contains no organic solvent, and has high safety, reduced toxic side effect and other advantages.

The invention discloses a preparation method of a purple cabbage anthocyanin-collagen chitosan composite intelligent film. The preparation method comprises the following steps: preparing purple cabbage anthocyanin powder from purple cabbage; then adding chitosan into an acetic acid aqueous solution, adding a collagen aqueous solution, continuously adding glycerol and sodium citrate, heating and stirring the mixture in a water bath, and cooling the mixture to obtain a collagen chitosan solution; and adding the purple cabbage anthocyanin powder into the collagen chitosan solution, uniformly stirring the solution, performing standing foaming treatment, injecting the obtained mixed solution into a mold, and drying the solution to obtain the purple cabbage anthocyanin-collagen chitosan composite membrane. The purple cabbage anthocyanin-collagen chitosan composite intelligent film can be applied to freshness indication and fresh-keeping storage of fresh products.

The invention relates to a novel straw direct gasification and poly-cogeneration device and preparation process. The device comprises a gasification furnace, a loading device, a pushing device, a pressing device, a distributing device, a carbon discharging device, a washing device, a fan, a water seal filtration device, a gas storage cabinet and a control cabinet. According to the invention, straw which does not need to be processed is directly fed into the gasification furnace for gasification through the loading, pushing, pressing and distributing devices, thereby effectively controlling straw cogenerated straw carbon and straw gas, matching a carbon shaving grate and the carbon discharging device to collect the straw carbon, carrying out labyrinth spraying and washing and separating the straw gas from straw extract, and filtering and collecting the straw gas in the water seal filtration device. The device has high reliability, good safety, strong practicability, simple gasification process, good gasification effect, high straw utilization ratio and low operation cost.

The invention relates to a liposome preparation for blackening hair and a preparation method of the liposome preparation. The liposome preparation is prepared from melanin, trace elements, protein polypeptide components for recovering normal metabolism of melanin, nucleic acid components for enhancing or repairing hair follicle genes, antioxidant related genes and / or cytokines beneficial to hair follicle health and the like efficiently. Functional biomacromolecules such as protein DNA are encapsulated by adopting liposome, so that the transdermal absorption efficiency can be greatly improved,normal metabolism of hair follicle melanin is effectively promoted, the scalp hair follicle health is maintained, and the blackening of white hair is promoted. Effective components, especially biomacromolecules, are wrapped by lipidosome, so that the transdermal absorption effect and the normal-temperature storage stability are greatly improved, the effective components can be accumulated on the epidermal layer of the skin, a long-acting slow-release effect is achieved, the local drug concentration is increased, and the treatment effect is enhanced. The liposome is similar to natural microcapsules in a human body in size and structure, has the characteristic of hair follicle affinity, targets hair follicles, and has the effects of promoting hair blacking and maintaining scalp health.

The invention provides hydrogel with ROS response and a preparation method and application thereof, during preparation, carbodiimide is used as a catalyst, catechol groups are grafted on chitosan macromolecules, and solubility and adhesion of chitosan are improved. Cystamine is used as a cross-linking agent, and amino of cystamine and benzoquinone formed after catechol groups are oxidized are subjected to Michael addition reaction to form a cross-linked network, so that the hydrogel is formed. The invention further discloses the hydrogel with ROS response prepared by the method and application of the hydrogel. The disulfide bond contained in cystamine can be broken and converted into sulfinic acid under the action of active oxygen, so that the structure of the hydrogel is destroyed, the hydrogel can play an intelligent drug release role in an atherosclerosis site where more active oxygen substances are generated, burst release of the drug in a diseased region is avoided, and risks of restenosis in blood vessels, delayed healing of endothelium, advanced thrombus and the like are expected to be reduced.

The invention discloses a preparation method and application of reduced glutathione lipidosome, relates to a preparation method and application of lipidosome, and aims at solving the technical problem of low inclusion rate of the lipidosome prepared by the existing method. The method comprises the following steps: 1, weighing soya bean lecithin and fatty acid glycerides, dissolving into absolute ethyl alcohol, and heating in a water bath to prepare an oil phase; 2, weighing reduced glutathione and a surfactant to be dissolved into distilled water, and heating in the water bath to prepare a water phase; 3, mixing the prepared oil phase with the water phase, emulsifying, carrying out vacuum rotary evaporation to remove absolute ethyl alcohol, adding distilled water, pre-cooling after ice-bath, and then carrying out freeze drying to obtain lipidosome powder. The reduced glutathione lipidosome disclosed by the invention is applied to intravenous injection, oral medication, transdermal drug delivery, and a drug delivery system for the lung and eyes. The encapsulation efficiency of the reduced glutathione lipidosome disclosed by the invention is 68.15%+ / -1.53%. The preparation method is applied to the field of preparation of the lipidosome.

The invention discloses a tobramycin liposome used for aerosol inhalation. The tobramycin liposome used for aerosol inhalation is composed of the following components: 0.1%-15.0% of tobramycin, 0.5%-36.0% of a phospholipid, 0.05%-20.0% of a stabilizer, 0.01%-10.0% of a charge modifier, 0.01%-5.0% of an antioxidant, 5.0%-50.0% of an organic-phase medium and the balance an aqueous-phase medium. According to the tobramycin liposome used for aerosol inhalation, the aerosol inhalation technology is used, relative to oral administration, the aerosol inhalation technology has the advantages that a medicine can be directly delivered to a respiratory tract, is absorbed fast, and takes effect quickly, and a medicine concentration of the respiratory tract is increased; the bioavailability and the stability are high, and the tobramycin liposome used for aerosol inhalation has good safety; and a production process is simple, easy and reasonable, and the performance is stable, so that conditions arecreated for achieving industrial productization.

The invention discloses a traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and a preparation method thereof. The traditional Chinese medicine composition comprises the components including first essential oil, second essential oil, a herba centellae extracting solution, chitosan, glucolactone and the like; the first essential oil is essential oil prepared from pine needles and coriander through supercritical CO2 extraction; and the agilawood essential oil (the second essential oil) is obtained through extraction with the supercriticalCO2 extraction technology, ethyl acetate is adopted as an entrainer during extraction, and meanwhile, agilawood is pretreated after being smashed before extraction, so that the extraction rate of theagilawood essential oil can be effectively increased. According to the traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and the preparationmethod thereof, the process design is reasonable, the operation is simple, the prepared traditional Chinese medicine composition not only has excellent inflammation diminishing, itching relieving, antibacterial and bacteriostatic effects, but also can be used for scalp inflammation treatment, the traditional Chinese medicine composition is relatively good in component stability, and a medicine has a long-acting slow-release effect. In actual use, the effect is better, and the practicability is relatively high.

The invention relates to a novel straw direct gasification polygeneration preparation process, comprising a gasification furnace, a feeding device, a material pushing device, a material pressing device, a material homogenizing device, a carbon discharging device, a washing device, a fan, a water seal filtering device, a gas holder and a control cabinet. By virtue of the feeding device, the material pushing device, a material pressing device and a material homogenizing device, straw requiring no processing is directly fed into a gasification furnace to be gasified, the straw is effectively controlled to polygenerate straw carbon and straw gas, a carbon scraping grate and the carbon discharging device are combined to collect the straw carbon, labyrinth type spraying washing is carried out to separate the straw gas and straw extract, the water seal filtering device filters and collects the straw gas, and the device has high reliability, good safety performance, strong practicability, simple gasification process, good gasification effect, high straw utilization rate and low operation cost.

The invention relates to glycyrrhetinic acid liposome, comprising, by weight, 1-20% of lecithin, 0.01-0.5% of glycyrrhetinic acid, 1-10% of water-soluble grease, 1-15% of polyols, 0.1-2% of a surfactant, 0.01-0.2% of an inorganic salt, and the balance of water. The invention also provides a preparation method of the glycyrrhetinic acid liposome. The method includes: dissolving the lecithin and the glycyrrhetinic acid in a mixture of the polyols and the water-soluble grease to obtain an organic phase; evenly dispersing the surfactant and the inorganic salt, and dissolving them in water to obtain an aqueous phase; slowly adding the organic phase at constant speed into the aqueous phase to obtain glycyrrhetinic acid liposome suspension; stirring the glycyrrhetinic acid liposome suspension under ultrasonic to obtain a uniform system, and allowing the system to naturally cool to the room temperature to obtain the glycyrrhetinic acid liposome. The glycyrrhetinic acid liposome obtained by using the method has the stable system, long and slow-release action and mild to skin.

The invention relates to a liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material and a preparation method thereof. The composite material is a compound of doxorubicin (doxorubicin) and a lactobionic acid modified multi-walled carbon nanotube CNT-PEI-FI-PEG-LA. The preparation method comprises the following steps: synthesizing the multi-walled carbon nanotube composite material CNT-PEI-FI-PEG-LA; formulating doxorubicin standard curves in two types of pH value environments; and dissolving the multi-walled carbon nanotube composite material in water, adding a doxorubicin hydrochloride aqueous solution, adjusting the pH value to neutrality and alkalinity, stirring for 4 hours, dialyzing, and carrying out freeze drying, thus obtaining the liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material. The liver cancer-targeted multi-walled carbon nanotube drug-loaded composite material has the characteristics of pH sensitive release and liver cancer cell targeting, can be used for anti-tumor research and has very high practical value.

The invention discloses an epirubicin loaded graphene quantum dot drug carrying system and a preparation method thereof. The preparation method includes the following steps: preparation of graphene quantum dots by a hydrothermal method; loading an anti-cancer drug with the graphene quantum dots; and performing a drug slow-release experiment, and performing a cytotoxicity test on the drug carrying system. The graphene quantum dots prepared by the hydrothermal method are used as a drug carrier for being loaded with epirubicin, greatly improve the drug loading rate, and show a quite good inhibitory effect on tumor HeLa cells. The preparation method of the drug carrying system is simple to operate, mild in reaction conditions and high in drug loading rate, and is expected to have a broad application prospect in the field of biological medicine.

The invention proposes a golf ball-shaped degradable microsphere with a microtopological structure and a preparation method thereof. The microsphere is composed of PCL and other polymer material components, the diameter of the microsphere is 1 μm to 600 μm, and the appearance is sunken or wrinkled inward. Spherical structure with microtopology. Simply arrange component A and component B according to the mass ratio of 99:1 to 50:50, and dissolve in organic solvent component C to form mixed solution component D, and then add stabilizer solution component E Component F is formed by stirring and mixing, and the stirring and mixing is continued until the organic solution in component F is completely volatilized to form component G. Wash component G with water or buffer solution as required to remove residual golf balls. The invention avoids the residue of chemical by-products and catalysts, the preparation process is simpler and the cost is lower, and the microtopological structure on the surface can promote cell adhesion and growth, which is beneficial to the fields of antibody production, three-dimensional cell culture, tissue repair, etc. promote.

The invention belongs to the technical field of biological medicine, and particularly relates to an exosome preparation suitable for mucosa and having a similar needle-free injection effect and a preparation method of the exosome preparation. Mesenchymal stem cells and lactic acid bacteria are co-cultured, supernatant is collected, cell factors and exosomes secreted by the mesenchymal stem cells are sequentially separated according to molecular weight through an ultrafiltration concentration technology, wherein the cell factors are encapsulated by lipidosome and coated with S-layer protein, then the cell factors and the exosomes are mixed in proportion, freeze-dried powder is prepared, and then the dry powder spray is prepared. The dry powder spray has a transdermal absorption effect similar to needle-free injection, is not easy to lose through vaginal mucosa administration, and can greatly reduce loss.

The invention discloses a tobramycin liposome for atomization inhalation, which consists of the following components: 0.1%-15.0% tobramycin, 0.5%-36.0% phospholipid, 0.05%-20.0% stabilizer, charge Modifier 0.01%~10.0%, antioxidant 0.01%~5.0%, organic phase medium 5.0%~50.0%, water phase medium balance; the tobramycin liposome for atomization inhalation of the present invention utilizes atomization inhalation Compared with oral administration, it can directly deliver the drug to the respiratory tract, absorb quickly, act quickly, and increase the drug concentration in the respiratory tract; the bioavailability and stability are high, and it has good safety; the preparation process is simple, easy and reasonable, Stable performance creates conditions for realizing industrial productization.

The invention relates to a high-tower compound fertilizer. The high-tower compound fertilizer contains a laver extract, industrial monoammonium, potassium sulfate, urea, monopotassium phosphate and amino acid chelated calcium. The high-tower compound fertilizer provided by the invention is friendly to the soil environment, has long-acting slow release property, can remarkably promote the root growth of crops on one hand, and can provide the stress resistance of the crops on the other hand.

The present invention relates to a tranexamic acid flexible liposome for whitening and removing freckles and its preparation method and application. ~12.0% phospholipids, 0.5%~5.0% cholesterol, 0.05%~1% membrane softener, 0.05%~1.0% ceramide, 0.5%~3.0% emollient, 5.0%~15.0% polyol, 0.5%~2.0 % antioxidants and the balance of purified water. The active ingredients in the tranexamic acid flexible liposome prepared by the present invention have complementary functions and can play a synergistic effect; the drug loading capacity is large, and active ingredients with different functions such as tranexamic acid can be transported to the deep layer of the skin to play a long-term effect. It improves the cumulative penetration and retention of tranexamic acid cream, improves the defects of oral administration of gastrointestinal adverse reactions, improves compliance, and is easy for patients to accept.

The invention discloses a PEG-PCL-PEG triblock copolymer modified madecassoside (MA) liposome and application thereof, belonging to the fields of pharmaceutical preparations, skin care products and daily chemical products. The MA liposome is prepared from the following components: a PEG-PCL-PEG triblock polymer, MA, cholesterol and lipid, wherein the MA is encapsulated in a liposome. The MA liposome is modified by the PEG-PCL-PEG triblock polymer, so that the fitting effect of a drug and the skin can be improved; especially, when being applied to the skin, the PEG-PCL-PEG triblock copolymer modified MA liposome can be converted into cream from liquid, thus achieving an effect of drug storage; therefore, the time of action between the MA and the skin is prolonged, the effect of long-actingslow release is realized, and the treatment effect is enhanced. A preparation method provided by the invention is simple in technology and easy to amplify; the PEG-PCL-PEG triblock copolymer modifiedMA liposome has wide application prospects in the aspects of later large-scale medical production and potential medical use.

The invention relates to a liver cancer-targeted graphene oxide drug-loaded composite material and a preparation method thereof. The composite material is a composite of doxorubicin DOX and lactobionic acid-modified graphene oxide GO-PEI-FI-PEG-LA things. Preparation: synthesis of graphene oxide composite material GO‑PEI‑FI‑PEG‑LA; preparation of doxorubicin standard curves in two pH environments; dissolving graphene oxide composite material in water, adding doxorubicin hydrochloride aqueous solution, And adjust the pH value to neutral alkaline, stir for 4 hours, dialyze, and freeze-dry to obtain the product; the new drug-loaded material of the present invention has the characteristics of pH-sensitive release and liver cancer cell targeting, and can be used for anti-tumor research, and has great advantages. Good practical value.

The invention discloses a traditional Chinese medicine composition for hyperplasia of mammary glands and a preparation method of a hydrogel patch thereof. The traditional Chinese medicine composition comprises figwort root, tangerine seed, lychee seed, diverse wormwood herb, Indian iphigenia bulb, honeylocust, rhizoma corydalis, seaweed, flos caryophyllata and garden balsam, and a pharmaceutical extract of the traditional Chinese medicine composition is obtained by extraction. The preparation method of the hydrogel patch of the traditional Chinese medicine composition for the hyperplasia of the mammary glands comprises the following steps: using a framework material, a tackifier, a humectant, a preservative, a filler, a crosslinking agent, a crosslinking regulator, a pH regulator, the pharmaceutical extract and distilled water to prepare a medicine-loaded hydrogen patch matrix; and then performing coating, cutting, standing and other steps, thus obtaining the hydrogel patch. The traditional Chinese medicine composition has a target treatment role of directly delivering the pharmaceutical active ingredients to tissues with hyperplasia lesion of the mammary glands, has the long-acting sustained-release role for sustained release of the pharmaceutical active ingredients for a long time, is convenient and comfortable to use and has the advantages of no skin irritation, no allergy and the like, thereby being an ideal pharmaceutical preparation for treating the hyperplasia of the mammary glands.

The invention relates to a molybdenum oxide nanosheet plugging hollow mesoporous silicon nanomaterial and its preparation and application, molybdenum oxide MoO modified by polyethylene glycol-modified distearoylphosphatidylethanolamine mPEG‑DSPE x Nanosheets plugging hollow mesoporous silicon, obtained. The preparation method of the invention is simple to operate, the experimental conditions are easy to control, and has the prospect of industrial implementation.