3 results about "RGD peptide" patented technology

This invention discloses an arginine-glycine-aspartic acid (RGD) peptide-modified chiral atomically precise metal nanoclusters, their preparation, and applications. The RGD peptide-modified chiral atomically precise metal nanoclusters consist of an atomically precise metal core, a chiral RGD peptide ligand layer, and linking molecules connecting the metal core and ligand layer. The chiral regulation and targeting functions of the RGD peptide-modified chiral atomically precise metal nanoclusters synergistically enhance their targeting and penetration at the tissue and cellular levels, thereby improving their uptake efficiency. After optimization with α... v The binding constant of β3 integrin is 1.4 × 10⁻⁶. ‑6 M ‑1 RGD peptides modify the ultrasmall metal cores of chiral atomically precise metal nanoclusters, endowing them with highly efficient and rapid renal clearance properties. This invention provides a solution suitable for various α-cell tumors, arthritis, liver fibrosis, and other conditions. v RGD peptides modified with chiral atomic precision metal nanoclusters, used to treat diseases with high expression of β3 integrin, can achieve efficient enrichment at target sites for imaging.

The present application relates to the field of hydrogel, in particular to an antibacterial medical hydrogel and its preparation method and application. The raw materials of the hydrogel include tri-lysine, functional polypeptide, multi-arm-polyethylene glycol derivative and polyethyleneimine, wherein the amino acid sequence of the functional polypeptide includes RGD peptide and the polypeptide described in SEQ ID NO. 1. The hydrogel has the effects of antibiosis and promoting fibroblasts by adding the functional polypeptide, which is beneficial to the healing of wounds and has a wide application prospect in wound sealing.