87 results about "Artificial bone" patented technology

The invention discloses a ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method comprises the following steps: constructing an amphiphilic micelle system through a PEG-PLA (Polyethylene Glycol-Polylactic Acid) block copolymer, firstly preparing a micelle solution, then applying the micelle solution to precursor slurry preparation and PLGA pore-forming agent pretreatment (solving the problems of compatibility and agglomeration) in stages, molding and drying, and then carrying out gradient sintering (removing an auxiliary agent at low temperature and promoting densification at high temperature) to obtain the product. The method solves the problems of poor compatibility of a pore-forming agent and a precursor, powder agglomeration and uneven pore structure in a traditional process, and the obtained material has a three-dimensionally communicated and uniformly distributed micropore structure and is uniform in component.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

The invention discloses an absorbable soft artificial bone material and a preparation method thereof, and relates to the technical field of medical materials. The absorbable soft artificial bone material comprises the following raw materials in parts by weight: 30-60 parts of bioactive glass, 20-50 parts of collagen, 10-30 parts of a reinforcing agent, 1-3 parts of an antibacterial agent, 5-10 parts of a pore forming agent and 100-180 parts of deionized water. The absorbable soft artificial bone material prepared by the invention has good compressive strength and fracture toughness and excellent antibacterial performance.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention discloses a cobaltosic oxide-carbon co-doped hydroxyapatite artificial bone material and a preparation method thereof, and belongs to the technical field of biomedical ceramic materials. According to the method, hydroxyapatite is used as a matrix, potassium hexacyanocobaltate is used as a cobalt source and carbon source precursor, cobaltosic oxide nanoparticles and a carbon phase are generated in situ through loading and staged gradient sintering in an inert atmosphere, and the artificial bone scaffold material is obtained through forming and degreasing. The cobaltosic oxide in the obtained material can refine grains and improve the mechanical strength, the in-situ carbon phase serves as a flexible toughening phase to reduce the brittleness, and the cobaltosic oxide and the in-situ carbon phase cooperate to achieve synchronous improvement of the strength and the toughness; and meanwhile, the precursor is pyrolyzed to produce gas and cooperatively form pores, so that a three-dimensional porous structure with excellent connectivity is formed. The preparation method is simple in process and good in dispersion uniformity, and the problems that pure hydroxyapatite is poor in mechanical property, high in brittleness, insufficient in pore connectivity and the like are solved.

The utility model relates to the technical field of medical instruments, in particular to a PEEK artificial bone material installation auxiliary instrument which comprises a face auxiliary limiting elastic cover used for conducting auxiliary limiting on PEEK artificial bone materials after face shaping and a nasal groove abutting device used for preventing nasal groove hyperplasia after nasal base filling. The face auxiliary limiting elastic cover comprises a cover body, a head circumference adjusting fastening belt and a top fixing belt, the cover body is matched with the human face structure, wearing ear through holes are reserved in the two sides of the cover body, a forehead through groove, an eyebrow bone eye through groove, a nose through groove and a lip through groove are sequentially formed in the cover body from top to bottom in a penetrating mode, and the forehead through groove is matched with the human forehead structure. The inner walls of the two sides of the forehead through groove are connected with forebone side face abutting plates with the postoperative forehead joint protruding. Through a plurality of fixing points and an adjusting mechanism, the stability and adaptability are improved, it can be ensured that the PEEK artificial bone material can be kept at an ideal position after an operation, the stability of an operation site is facilitated, the displacement risk is reduced, and the operation success rate is increased.

The application discloses a kind of ceramic artificial bone materials and preparation method thereof, belong to ceramic material preparation technical field.The method is constructed amphiphilic micellar system by PEG-PLA block copolymer, first preparation micellar solution, then it is used for precursor slurry preparation and PLGA pore former pretreatment (solve compatibility and agglomeration problem) in stages, after forming and drying, by gradient sintering (low temperature to aid agent, high temperature promotes densification) obtain product.The application solves the problem that pore former and precursor are compatible in traditional process, powder agglomeration, pore structure is uneven, and the obtained material has three-dimensional connected and uniformly distributed micropore structure, and uniform composition.

The application provides an artificial bone material and a preparation method thereof, wherein the material quality of the artificial bone material includes, with the total dry matter of the artificial bone material being 100%, 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen, and 0-7% of excipients. The artificial bone material provided by the application has high porosity and a longitudinal gradient structure, can simulate the characteristics of natural bone tissue, and has excellent biocompatibility, biodegradability, hydrophilicity, osteogenic performance and shape memory function.

A method for treating an artificial bone implant with blood, according to the method bone material is placed in a container configured to be filled with blood, wherein the container comprises an opening and a cover configured to cover the opening of the container and a fixed separator that separates a bottom part and an upper part. The separator is provided with holes so that when the container is filled with whole blood, the blood in the bottom part is in full contact with the blood in the upper part, and wherein the bone material is in the upper part, on top of the separator.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

This utility model relates to the field of orthopedic implant technology and discloses a prosthesis for defects after partial atlas resection. It aims to solve the problems of existing technologies, such as the lack of atlas prosthesis implants, long recovery times after autologous bone grafting, and the ineffective fixation of titanium mesh implants. This utility model includes a prosthesis that replaces the atlas, with bone screw holes to accommodate bone screw fixation contact points. The prosthesis includes an outer frame, which is a porous tubular or porous columnar structure. The cavity of the porous tubular structure is filled with autologous bone, allogeneic bone, or artificial bone. The upper and lower ends of the outer frame are provided with curved surfaces matching the facet joints of the occipital condyle and axis, and a support unit is provided within the outer frame. This utility model, combined with 3D printing technology, matches the shape of the corresponding segment and resection site, thereby replacing the resected segment, promoting the fusion of the atlantoaxial segment, and facilitating the restoration of the physiological function of the upper cervical spine.

1. Name of the designed product: packing bag (human bone). 2. Use of the designed product: used for packing artificial bone product, also used for packing other medical products. 3. Design points of the designed product: in shape. 4. Picture or photo showing the design points: perspective view.

The invention discloses a high-connectivity porosity SiO2 / HA composite ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method adopts a synergistic process of template pretreatment, precise compounding and gradient calcination, and comprises the following steps: preparing SiO2 (at) PAA micelle particles, carrying out synergistic modification on the SiO2 (at) PAA micelle particles by SDS and Tween 80, mixing the SiO2 (at) PAA micelle particles with HA powder, regulating and controlling the stirring speed to prepare composite slurry, and carrying out gradient calcination to obtain the product. Regulating and controlling by ammonia water to enable SiO2 to form a broken cavity structure, and constructing a high-connectivity pore network; the double surfactants avoid particle aggregation, and low-speed stirring ensures the pore-forming effect. The material has high connectivity porosity and excellent mechanical properties, HA and an open pore SiO2 interface are tightly combined, bone tissue ingrowth and substance transmission can be promoted, the problems that a traditional HA material is large in brittleness, poor in pore connectivity, SiO2 agglomeration and the like are solved, the process is simple and controllable, and the material is suitable for large-scale production and scenes such as load-bearing bone repair.

The application belongs to the technical field of biomaterial ink, and particularly relates to a composite 3D printing biomaterial ink, a preparation method and application thereof. The composite 3D printing biomaterial ink comprises, by weight percentage, 12-18% of polyethylene glycol 400, 28-22% of pluronic F127 solution, and the balance of self-curing artificial bone particles; wherein the self-curing artificial bone particles are one or more of dicalcium silicate, tricalcium silicate and calcium dihydrogen phosphate. The composite biomaterial ink prepared by the application has good printability, physical and chemical properties, in-vitro degradation behavior and in-vitro biocompatibility, and has a good application prospect in the field of bone tissue engineering.

Disclosed in the present invention are a novel artificial bone based on promoting neurovascular regeneration and a preparation method. The novel artificial bone comprises an artificial bone. The artificial bone is composed of β-tricalcium phosphate, polylactic acid-glycolic acid, a nano magnesium-based powder, and a piezoelectric polymer. The mass ratio of β-tricalcium phosphate to polylactic acid-glycolic acid in the artificial bone is 1:0-1:10. The nano magnesium-based powder and the piezoelectric polymer are mixed to form a piezoelectric composite solution, and the mass ratio of the nano magnesium-based powder to the piezoelectric polymer in the piezoelectric composite solution is 1:1-1:20, such that the surface of the artificial bone is modified by means of the piezoelectric composite solution, thereby forming a piezoelectric coating on the surface of the artificial bone; in this way, when the artificial bone is implanted into a bone defect site and is subject to stress, a charge and potential difference are generated. The present invention not only enhances the strength of the artificial bone, but also promotes the degradation of the artificial bone, stimulates local neurovascular regeneration, promotes the formation of new bone, and achieves the purpose of repairing osteonecrosis and bone defects.

The utility model relates to medical instrument technical field, specifically disclose a skull repair device of integrated cerebrospinal fluid shunt, including artificial bone plate, be used for repairing skull defect, the outer surface of artificial bone plate is equipped with positioning recess, the positioning recess is used for accommodating cerebrospinal fluid shunt, and the positioning recess is equipped with the fixing assembly for fixing shunt. The utility model embeds the main part of cerebrospinal fluid shunt into artificial bone plate, makes shunt main part can accommodate in the thickness range of repair device itself, thereby significantly reduced the overall profile height of implant, effectively reduced the pressure and tension generated to scalp, can prevent the scalp erosion, breakage, necrosis and other serious complications caused by implant profile too high, simultaneously, through the fixing assembly to the shunt fixation, can effectively prevent the shunt from turning over or displacement after operation, guarantee the long-term stability and safety of drainage system, and simplify the operation.

The invention discloses a personalized implantation structure and method for improving insufficient chin anterior movement in a chin shaping surgery, the personalized implantation structure comprises an implant and a chin anterior movement osteotomy matched with the implant, and the implant is fixed on the chin anterior movement osteotomy. Compared with the prior art, osteotomy forward movement and the implant are combined together to be applied to the chin forming operation, and when the chin bone mass of a patient is insufficient, supplementation can be conducted through the implant. Compared with an autogenous bone or an artificial bone for transplantation, the implant does not need to face the problems of absorption, rejection and the like, and the risk of a secondary operation cannot be increased; meanwhile, compared with the mode that the prosthesis is completely adopted for implantation, the burden of mandibular fibrous tissue can be relieved, and the risk of implant displacement can also be reduced.

The invention relates to the technical field of artificial bone materials, and discloses a hydrogel / polymer composite scaffold and a preparation method and application thereof, the composite scaffold comprises hydrogel, a porous polymer scaffold and optional living cells; wherein the living cells are encapsulated in hydrogel, pores of the porous polymer scaffold are filled with the hydrogel, and the hydrogel contains an aldehyde polymer and an amino-containing polymer; the weight ratio of the aldehyde polymer to the amino-containing polymer is (0.2-5): 1; the weight-average molecular weight of the material of the porous polymer scaffold is greater than 20,000 g / mol, the pore size of the porous polymer scaffold is 300-800 [mu] m, and the porosity is 40-70%. According to the hydrogel / polymer composite scaffold provided by the invention, living cells can be packaged, an extracellular matrix can be simulated, the defects of a traditional polymer scaffold are effectively overcome, and the biocompatibility is greatly improved.

The invention relates to a moldable collagen-based artificial bone repair material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the preparation method of the moldable collagen-based artificial bone repair material, the bone repair material with excellent water absorption, plasticity and operability is obtained, the softening condition of the bone repair material is not limited, the material can be softened by normal-temperature normal saline without additional treatment such as heating, the use method is simple, and the cost is low. The device can be used in defect repair operations in the department of stomatology and the department of orthopaedics, and is wide in adaptation disease.

This invention discloses a method for preparing and applying a hyperelastic metallic metamaterial. The preparation method includes: selecting a bending metamaterial based on the Maxwell equation, which is: m = b - 3j + 6, where b and j are the number of rods and nodes, respectively, and the material is a bending metamaterial when m is less than 0; selecting a matrix material and preparing the hyperelastic metallic metamaterial using laser powder bed melting 3D printing. In particular, the bending metamaterial can be selected from body-centered cubic metamaterials, face-centered cubic metamaterials, or orthogonal dodecahedral metamaterials. The elastic strain of the hyperelastic metallic metamaterial in this invention is about 10 times that of existing commercial metallic materials, an improvement of nearly an order of magnitude, and has important application value in the field of engineering materials such as artificial bone energy absorbers in medical devices.

The invention relates to the field of biomedical materials, and discloses a preparation method of a calcium-phosphorus-based biological ceramic artificial bone, which comprises the following steps: firstly, constructing a Ca-P core-shell precursor containing a Zn < + > enriched core and a Sr < + > enriched shell, and carrying out directional diffusion induction treatment through short-time microwave pulse or thermal pulse to activate core-shell interface ion migration without causing complete crystallization; the beta-TCP powder obtained through freeze drying and segmented calcination is uniform in doped element distribution. And then composite printing slurry containing PVA and MC and added with sodium alginate and nano-clay is adopted, so that the slurry is quickly crosslinked and cured under ultraviolet light, and the extrusion stability and interlayer bonding strength are remarkably improved. And finally, carrying out microwave-assisted sintering to obtain the ceramic scaffold with high density, high mechanical property and good biological activity. According to the method, uniform synergistic doping of Zn < + > / Sr < + > is achieved, the mechanical strength, printing precision and osteogenesis promotion and antibacterial performance of the stent are improved, and the method is suitable for preparing the high-performance bone regeneration stent.

The invention relates to a polyvinyl alcohol-based hydrogel composite material as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. According to the main technical scheme, the preparation method of the polyvinyl alcohol-based hydrogel composite material comprises the following steps: applying directional circulating tension to polyvinyl alcohol-based hydrogel to obtain the polyvinyl alcohol-based hydrogel with a directional fiber structure; wherein the fiber diameter of the oriented fiber structure is 20 nm to 5 [mu] m; performing mineralization self-assembly treatment and curing treatment on the polyvinyl alcohol-based hydrogel with the oriented fiber structure to obtain mineralized hydrogel with the oriented fiber structure; and carrying out heat treatment on the mineralized hydrogel with the oriented fiber structure to obtain the polyvinyl alcohol-based hydrogel composite material. The preparation method is used for preparing the high-toughness polyvinyl alcohol-based hydrogel composite material with a directional structure similar to a human cortical bone, and the high-toughness polyvinyl alcohol-based hydrogel composite material is used as an artificial bone repair material.

The present disclosure describes a modular bone implant device, which is artificial bone material for repairing bone defects, comprising a plurality of assembled filling units, each filling unit having a hole and an interlocking mechanism for mutual assembly, after the plurality of filling units are assembled by the interlocking mechanism, each hole forms an internal passage through the bone implant device in at least one direction, the filling units are made of degradable biological material, and the elastic modulus of the filling units is always not less than the elastic modulus of the host bone during the repair period, and the ratio of the two decreases over time. Thus, a modular bone implant device with good structural stiffness, flexible assembly and degradation absorption can be provided.

The invention discloses a customized tibia prosthesis, and relates to the technical field of skeleton prostheses, the customized tibia prosthesis comprises a tibia prosthesis main body, the two opposite ends of the tibia prosthesis main body are both provided with positioning bosses, the section of each positioning boss is the same as the shape of a marrow cavity of a tibia backbone, and the positioning bosses are used for being embedded into the marrow cavity of the tibia backbone; the tibia artificial bone body further comprises a pore support and a solid support, the pore support is of a porous structure, and the solid support is fixedly connected with the pore support. And the dense pore structures of the positioning boss and the pore bracket are beneficial to promoting the formation of new bone tissues, so that the bone tissues can grow in each pore, and the tibia prosthesis has enough mechanical stability and long-term ossification support. The bone prosthesis has the technical effect of improving the adaptive positioning performance and stability of the bone prosthesis and the original bone.

The invention belongs to the field of bone tissue engineering scaffold materials, and particularly relates to a degradable artificial bone scaffold as well as a preparation method and application thereof in determination of an ideal osteogenesis rate. According to the invention, polylactic acid (PLA) and polyvinylpyrrolidone (PVP) are used as raw materials to prepare the PLA stent with controllable degradation rate through a steam induced phase separation method, and the PLA stent not only can adapt to bone tissue regeneration rates of different species or parts through control of the degradation rate, but also can be used for determination of ideal osteogenesis rate.

Disclosed herein are MXene-aromatic thermosetting copolyester nanocomposites. In one aspect, the nanocomposites can be used to fabricate and / or coat artificial bone implants. In another aspect, the nanocomposites are biocompatible and / or nontoxic. Implants and coatings formed from the nanocomposites possess excellent compressive strength, hardness, and wear resistance in synovial fluid when compared to current implant coatings and materials.

This invention relates to the fields of biomedical engineering and intelligent manufacturing technology, and discloses a multi-objective optimization design method for biomimetic artificial bone based on machine learning, including the following steps: 1) image acquisition and three-dimensional model establishment; 2) structural partitioning and performance requirement allocation; 3) generation of composite TPMS units; 4) mesh generation and simulation preparation; 5) machine learning prediction and reverse design. This invention overcomes the shortcomings of existing single structures that cannot simultaneously meet the initial stability and long-term bone regeneration requirements of implants. Through a performance-driven gradient design strategy, the external bearing area and the internal growth area can achieve a natural transition in the same structure, avoiding structural abrupt changes and mechanically weak areas caused by traditional methods.

The utility model discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof, the engineering construction composite artificial bone comprises a bioactive material and a mechanical support bracket, the bioactive material is used as a main body, the mechanical support bracket is contained in the bioactive material, and the bioactive material and the mechanical support bracket are tightly combined to form an artificial bone tissue complex. The mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. According to the utility model, the osseointegration performance and the mechanical property of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

Methods, systems, apparatuses, and computer program products are described herein for printing artificial constructs or tissue models from a bioink using digital light processing (DLP). Bioinks can include polyethylene glycol diacrylate (PEGDA), gelatin methacrylate (GelMA), hyaluronic acid methacrylate (HAMA), lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), tartrazine, arginine-glycerine-aspartic acid (RGD), isoleucine-lysine-valine-alanine-valine (IKVAV), and Dulbecco's Phosphate-Buffered Saline (dPBS) pH buffered with calcium and magnesium. Such bioinks can result in printed constructs that exhibit improved vascularity / perfusability and improved stem cell growth and regulation. Bioink can be formed by vortexing a solution of PEGDA, GelMA, HAMA, LAP, tartrazine, RGD, IKVAV, and / or dPBS at a temperature of, e.g., about 60°C or greater. DLP bioprinting can be carried out layer-by-layer with an average thickness of each layer being between about 25 µm and about 100 µm. Average light intensity emitted during DLP bioprinting can be between about 10 mW / cm2 and about 30 mW / cm2.