154 results about "Artificial bone" patented technology

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

The invention relates to multi-scale modeling and mechanical and thermodynamic property simulation of a particle reinforced biological composite material, and belongs to the crossing field of biology, material science and computer simulation. The method specifically comprises the following steps: constructing a polyether-ether-ketone (PEEK) high-molecular polymer and a graphene reinforced composite material model thereof through a cross-linking algorithm under a microscopic scale, and simulating and calculating the mechanical and thermodynamic properties of the model by adopting molecular dynamics; in the microscopic scale, constructing a representative volume element model of the microstructure artificial skeleton, inputting property parameters calculated by molecular dynamics into a microscopic model, and calculating microscopic mechanical and thermodynamic properties of the model by adopting a substance point method; and inputting the property parameters obtained under the microscale into the macroscopic model, and calculating the overall macromechanical and thermodynamic behavior response of the material by adopting a finite element method. According to the method, mechanical and thermodynamic responses of the biological composite material are finally simulated through transmission of property parameters of different scales, and theoretical support is provided for research and formula design of the particle reinforced biological composite material.

The invention relates to the technical field of biomedical materials, in particular to an artificial bone composite material and a preparation method thereof. The preparation method of the artificial bone composite material comprises the following steps: sequentially adding a CaCl2 solution and a NaH2PO4 solution into a collagen solution in proportion. And adjusting the pH value to 7.4, and collecting white jelly. Dispersing the white jelly in distilled water to obtain a colloid I; respectively adding the colloid I and the modified polyether-ether-ketone powder into a dichloromethane solution containing poly-L-lactic acid in proportion to obtain a mixed solution II, and then adding an ethanol solution for precipitation; and removing the precipitate in the mixed solution II to obtain the slurry. Injecting the slurry into a mold to obtain an intermediate I, and soaking the intermediate I in an EDC / NHS ethanol solution for crosslinking; according to the preparation method, the artificial bone composite material with high mechanical strength and good biocompatibility can be prepared, the defect that the biocompatibility and mechanical strength resistance of the artificial bone composite material cannot be obtained at the same time in the prior art can be overcome, and the practicability of the artificial bone composite material is improved.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention relates to a drug-loaded bone filling material, a preparation method thereof and application of the drug-loaded bone filling material in inhibition of relapse of opioid drugs. The drug-loaded bone filling material is prepared from the following raw materials: powder and curing liquid, the powder comprises a mixture of an opioid receptor antagonist and inorganic calcium salt; in the powder, the mass ratio of the opioid receptor antagonist to the inorganic calcium salt is 4-20%. After a performance test, the drug-loaded bone filling material has the advantages of proper coagulation time, good compressive strength and better drug sustained release characteristic, on one hand, artificial bones capable of promoting osteoblast differentiation can be filled in a bone defect area, and on the other hand, side effects caused by opioid drugs can be relieved, and symptoms can be relieved; meanwhile, for relieving opioid addicts, long-time drug action can be maintained, relapse can be prevented or reduced, and the pharmaceutical composition has great application potential in promoting osteoblast differentiation or inhibiting relapse of opioid drugs.

The invention discloses a ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method comprises the following steps: constructing an amphiphilic micelle system through a PEG-PLA (Polyethylene Glycol-Polylactic Acid) block copolymer, firstly preparing a micelle solution, then applying the micelle solution to precursor slurry preparation and PLGA pore-forming agent pretreatment (solving the problems of compatibility and agglomeration) in stages, molding and drying, and then carrying out gradient sintering (removing an auxiliary agent at low temperature and promoting densification at high temperature) to obtain the product. The method solves the problems of poor compatibility of a pore-forming agent and a precursor, powder agglomeration and uneven pore structure in a traditional process, and the obtained material has a three-dimensionally communicated and uniformly distributed micropore structure and is uniform in component.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

The invention provides coral hydroxyapatite as well as a preparation method and application thereof, the aperture of the coral hydroxyapatite is 30-1300 microns, the porosity is 50-70%, and the conversion rate is more than 50%. The preparation method comprises the following steps: soaking pretreated corallite in a cutting protective agent, cutting to obtain cut corallite, and screening the cut corallite meeting the cutting size requirement to obtain a cut corallite good product; and fully soaking the cut corallite good product with a phosphate solution, and carrying out a water heat exchange reaction to obtain the coral hydroxyapatite, the cutting protective agent is a solution containing polyol. According to the preparation method disclosed by the invention, the cutting efficiency can be obviously improved, the cutting specification and dimension can be widened, the product yield, particularly the yield of small-specification and dimension products, can be obviously improved, and the application range of the artificial bone is further widened.

The invention discloses an absorbable soft artificial bone material and a preparation method thereof, and relates to the technical field of medical materials. The absorbable soft artificial bone material comprises the following raw materials in parts by weight: 30-60 parts of bioactive glass, 20-50 parts of collagen, 10-30 parts of a reinforcing agent, 1-3 parts of an antibacterial agent, 5-10 parts of a pore forming agent and 100-180 parts of deionized water. The absorbable soft artificial bone material prepared by the invention has good compressive strength and fracture toughness and excellent antibacterial performance.

Provided are a preparation process for a modified hydroxyapatite and the use thereof. The preparation process comprises the following steps: S1. removing impurities from coral by using a sodium hypochlorite solution, followed by crushing to obtain coral particles; S2. subjecting the coral particles and a phosphate solution to a hydrothermal reaction at a pH value of 9-11 to obtain coralline hydroxyapatite; S3. mixing and reacting the coralline hydroxyapatite and an ion source to obtain an ion source-doped coralline hydroxyapatite; and S4. heating the ion source-doped coralline hydroxyapatite, and sintering and cooling same to obtain an ion source-doped coralline β-tricalcium phosphate, wherein the ion source comprises a strontium source. The modified hydroxyapatite prepared by the preparation process has a better degradation performance and mechanical adaptability, which improves the biological activity and osteoinductivity of coral artificial bones, and facilitates bone tissue ingrowth.

The invention discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof.The engineering construction composite artificial bone comprises a bioactive material and a mechanical supporting scaffold, the bioactive material serves as a main body, the mechanical supporting scaffold is contained in the bioactive material, and the bioactive material and the mechanical supporting scaffold are tightly combined to form an artificial bone tissue complex; the mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. The bone integration performance and mechanical performance of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

1. The name of the product of this design: Blister box (artificial bone paste mixing injection kit). 2. Purpose of the product with this design: The product with this design is used to contain artificial bone paste mixing injection kit. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

A simulated anatomical joint includes a first artificial bone having a first articular surface, a second artificial bone having a second articular surface matable to the first articular surface to simulate a natural joint, and artificial ligaments connecting the first artificial bone to the second artificial bone. The artificial ligaments connect the first artificial bone to the second artificial bone such that the first articular surface is proximate to the second articular surface. The artificial ligaments connected to the first artificial bone and second artificial bone are adjustable to simulate stresses in a natural anatomical joint corresponding to the first artificial bone and second artificial bone.

The invention discloses a cobaltosic oxide-carbon co-doped hydroxyapatite artificial bone material and a preparation method thereof, and belongs to the technical field of biomedical ceramic materials. According to the method, hydroxyapatite is used as a matrix, potassium hexacyanocobaltate is used as a cobalt source and carbon source precursor, cobaltosic oxide nanoparticles and a carbon phase are generated in situ through loading and staged gradient sintering in an inert atmosphere, and the artificial bone scaffold material is obtained through forming and degreasing. The cobaltosic oxide in the obtained material can refine grains and improve the mechanical strength, the in-situ carbon phase serves as a flexible toughening phase to reduce the brittleness, and the cobaltosic oxide and the in-situ carbon phase cooperate to achieve synchronous improvement of the strength and the toughness; and meanwhile, the precursor is pyrolyzed to produce gas and cooperatively form pores, so that a three-dimensional porous structure with excellent connectivity is formed. The preparation method is simple in process and good in dispersion uniformity, and the problems that pure hydroxyapatite is poor in mechanical property, high in brittleness, insufficient in pore connectivity and the like are solved.

The utility model relates to the technical field of medical instruments, in particular to a PEEK artificial bone material installation auxiliary instrument which comprises a face auxiliary limiting elastic cover used for conducting auxiliary limiting on PEEK artificial bone materials after face shaping and a nasal groove abutting device used for preventing nasal groove hyperplasia after nasal base filling. The face auxiliary limiting elastic cover comprises a cover body, a head circumference adjusting fastening belt and a top fixing belt, the cover body is matched with the human face structure, wearing ear through holes are reserved in the two sides of the cover body, a forehead through groove, an eyebrow bone eye through groove, a nose through groove and a lip through groove are sequentially formed in the cover body from top to bottom in a penetrating mode, and the forehead through groove is matched with the human forehead structure. The inner walls of the two sides of the forehead through groove are connected with forebone side face abutting plates with the postoperative forehead joint protruding. Through a plurality of fixing points and an adjusting mechanism, the stability and adaptability are improved, it can be ensured that the PEEK artificial bone material can be kept at an ideal position after an operation, the stability of an operation site is facilitated, the displacement risk is reduced, and the operation success rate is increased.

The application discloses a kind of ceramic artificial bone materials and preparation method thereof, belong to ceramic material preparation technical field.The method is constructed amphiphilic micellar system by PEG-PLA block copolymer, first preparation micellar solution, then it is used for precursor slurry preparation and PLGA pore former pretreatment (solve compatibility and agglomeration problem) in stages, after forming and drying, by gradient sintering (low temperature to aid agent, high temperature promotes densification) obtain product.The application solves the problem that pore former and precursor are compatible in traditional process, powder agglomeration, pore structure is uneven, and the obtained material has three-dimensional connected and uniformly distributed micropore structure, and uniform composition.

The present invention discloses a mold and method for preparing a biomimetic bone radial gradient porous NiTi alloy, comprising the following steps: 1) mold design and assembly; 2) slurry preparation; 3) co-injection molding; 4) curing and drying; 5) degreasing and sintering; and 6) pore-forming agent removal. The biomimetic bone radial gradient porous nickel-titanium alloy prepared by the present invention has a relatively continuous porosity variation from 15% in the outer layer to a maximum of 70% in the inner layer, and an average pore size variation from 30 μm in the outer layer to over 400 μm in the inner layer. The mechanical properties are substantially matched to those of bone. The biomimetic bone radial gradient nickel-titanium alloy prepared by the method of the present invention can be used as an ideal artificial bone tissue repair or replacement material, and is suitable for directly preparing materials such as dental implants, artificial joints, and bone trauma products without the need for subsequent processing.

The application provides an artificial bone material and a preparation method thereof, wherein the material quality of the artificial bone material includes, with the total dry matter of the artificial bone material being 100%, 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen, and 0-7% of excipients. The artificial bone material provided by the application has high porosity and a longitudinal gradient structure, can simulate the characteristics of natural bone tissue, and has excellent biocompatibility, biodegradability, hydrophilicity, osteogenic performance and shape memory function.

A method for treating an artificial bone implant with blood, according to the method bone material is placed in a container configured to be filled with blood, wherein the container comprises an opening and a cover configured to cover the opening of the container and a fixed separator that separates a bottom part and an upper part. The separator is provided with holes so that when the container is filled with whole blood, the blood in the bottom part is in full contact with the blood in the upper part, and wherein the bone material is in the upper part, on top of the separator.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The present invention provides an artificial skeletal joint and a preparation method thereof, wherein the artificial skeletal joint comprises a skeletal joint body, a first micro-arc oxidation film layer, and a second micro-arc oxidation film layer; the skeletal joint body is made of a titanium alloy; the first micro-arc oxidation film layer is disposed on the joint movable surface of the skeletal joint body, and the second micro-arc oxidation film layer is disposed on the human bone contact surface of the skeletal joint body. The above-mentioned artificial skeletal joint adopts a double-surface treatment method to modify the surface of the titanium alloy skeletal joint body, and performs a micro-arc oxidation process strengthening treatment on the joint movable surface to prepare a first micro-arc oxidation film layer with high hardness, high elastic modulus, and low friction coefficient. The human bone contact surface is subjected to a micro-arc oxidation roughening treatment to prepare a second micro-arc oxidation film layer with low elastic modulus and biocompatibility, thereby meeting the requirements of different characteristics of different positions of the artificial skeletal joint and improving wear and stress shielding of bone tissue.

The utility model relates to the field of holder devices, in particular to an air pressure finger control valve type artificial ossicular implantation holder, which comprises a round tube, a first air channel and a second air channel, a first side hole and a second side hole are formed in the side wall of the round pipe, the first side hole is communicated with the first gas channel, and the second side hole is communicated with the second gas channel; a first conical groove is formed in the left side of the partition plate, a second conical groove is formed in the left side of the round pipe, first semi-arc-shaped grooves are formed in the upper portion and the lower portion of the first conical groove, third semi-arc-shaped grooves are formed in the upper portion and the lower portion of the outer wall of the round pipe, and the two first semi-arc-shaped grooves communicate with the two third semi-arc-shaped grooves correspondingly. The device can stably fix and place the ossicular prosthesis, so that the ossicular prosthesis can be conveniently and stably transported to a preset position.

This utility model relates to the field of orthopedic implant technology and discloses a prosthesis for defects after partial atlas resection. It aims to solve the problems of existing technologies, such as the lack of atlas prosthesis implants, long recovery times after autologous bone grafting, and the ineffective fixation of titanium mesh implants. This utility model includes a prosthesis that replaces the atlas, with bone screw holes to accommodate bone screw fixation contact points. The prosthesis includes an outer frame, which is a porous tubular or porous columnar structure. The cavity of the porous tubular structure is filled with autologous bone, allogeneic bone, or artificial bone. The upper and lower ends of the outer frame are provided with curved surfaces matching the facet joints of the occipital condyle and axis, and a support unit is provided within the outer frame. This utility model, combined with 3D printing technology, matches the shape of the corresponding segment and resection site, thereby replacing the resected segment, promoting the fusion of the atlantoaxial segment, and facilitating the restoration of the physiological function of the upper cervical spine.

The utility model discloses an adjustable interbody fusion cage which comprises a group of fusion blocks which are symmetrically arranged up and down and further comprises a front propelling block, a rear propelling block and an adjusting assembly, the adjusting assembly is connected with the front propelling block and the rear propelling block and can adjust the distance between the front propelling block and the rear propelling block, and the front propelling block comprises a group of combined plates of the same structure. And the two combined plates are connected through sunk screws. The distance between the upper fusion block and the lower fusion block is adjusted through the arranged adjusting assembly, then the range of the practical gap of the fusion device is adjusted, and continuous height adjustment of the fusion device is achieved. Meanwhile, the bone paste injection channel is arranged, so that the artificial bone paste can be conveniently injected after the fusion cage is implanted, and different amounts of artificial bone paste can be implanted according to different operation conditions.

1. Name of the designed product: packing bag (human bone). 2. Use of the designed product: used for packing artificial bone product, also used for packing other medical products. 3. Design points of the designed product: in shape. 4. Picture or photo showing the design points: perspective view.

The invention discloses a high-connectivity porosity SiO2 / HA composite ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method adopts a synergistic process of template pretreatment, precise compounding and gradient calcination, and comprises the following steps: preparing SiO2 (at) PAA micelle particles, carrying out synergistic modification on the SiO2 (at) PAA micelle particles by SDS and Tween 80, mixing the SiO2 (at) PAA micelle particles with HA powder, regulating and controlling the stirring speed to prepare composite slurry, and carrying out gradient calcination to obtain the product. Regulating and controlling by ammonia water to enable SiO2 to form a broken cavity structure, and constructing a high-connectivity pore network; the double surfactants avoid particle aggregation, and low-speed stirring ensures the pore-forming effect. The material has high connectivity porosity and excellent mechanical properties, HA and an open pore SiO2 interface are tightly combined, bone tissue ingrowth and substance transmission can be promoted, the problems that a traditional HA material is large in brittleness, poor in pore connectivity, SiO2 agglomeration and the like are solved, the process is simple and controllable, and the material is suitable for large-scale production and scenes such as load-bearing bone repair.

The application belongs to the technical field of biomaterial ink, and particularly relates to a composite 3D printing biomaterial ink, a preparation method and application thereof. The composite 3D printing biomaterial ink comprises, by weight percentage, 12-18% of polyethylene glycol 400, 28-22% of pluronic F127 solution, and the balance of self-curing artificial bone particles; wherein the self-curing artificial bone particles are one or more of dicalcium silicate, tricalcium silicate and calcium dihydrogen phosphate. The composite biomaterial ink prepared by the application has good printability, physical and chemical properties, in-vitro degradation behavior and in-vitro biocompatibility, and has a good application prospect in the field of bone tissue engineering.

The utility model relates to the technical field of artificial bone structures, in particular to an improved PEEK (polyetheretherketone) screen plate which comprises a plate body corresponding to a skull repair position in shape, a plurality of fixing grooves formed in the outer edge of the upper end of the plate body in a staggered manner and a plurality of through holes formed in the middle of the plate body in a rectangular array manner. The outer side of the plate body is provided with a suture fixing structure used for assisting in suturing and fixing muscular tissue to the outside of the plate body through a suture line. According to the utility model, the original PEEK skull mesh plate structure is scientifically and reasonably improved, and the mesh plate is provided with two forms of line fixing structures which are used for assisting in suturing and fixing muscular tissues outside the plate body through sutures, so that the temporomuscle muscular tissues can be conveniently sutured and fixed outside the mesh plate along a track; the fixing device is simple in structure and convenient to use, temporal muscles can be attached to the net plate easily, muscle contracture is avoided, the workload and difficulty of actual operation of medical staff are effectively reduced, and therefore the convenience and efficiency of actual fixing operation of the PEEK net plate are improved.