178 results about "Artificial bone" patented technology

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

The invention relates to multi-scale modeling and mechanical and thermodynamic property simulation of a particle reinforced biological composite material, and belongs to the crossing field of biology, material science and computer simulation. The method specifically comprises the following steps: constructing a polyether-ether-ketone (PEEK) high-molecular polymer and a graphene reinforced composite material model thereof through a cross-linking algorithm under a microscopic scale, and simulating and calculating the mechanical and thermodynamic properties of the model by adopting molecular dynamics; in the microscopic scale, constructing a representative volume element model of the microstructure artificial skeleton, inputting property parameters calculated by molecular dynamics into a microscopic model, and calculating microscopic mechanical and thermodynamic properties of the model by adopting a substance point method; and inputting the property parameters obtained under the microscale into the macroscopic model, and calculating the overall macromechanical and thermodynamic behavior response of the material by adopting a finite element method. According to the method, mechanical and thermodynamic responses of the biological composite material are finally simulated through transmission of property parameters of different scales, and theoretical support is provided for research and formula design of the particle reinforced biological composite material.

The invention discloses a high-strength artificial bone repair material and a preparation method thereof. According to the preparation method, collagen and calcium phosphate are taken as raw materials, and the artificial bone repair material is formed through the following step S100 or step S200. The step S100 comprises the following steps: mixing a collagen solution and calcium phosphate, adding a cross-linking agent to obtain collagen hydrogel, compressing to remove free water in the hydrogel so as to reduce the volume of the hydrogel, and freeze-drying for forming; the step S200 comprises the following steps: uniformly mixing collagen and calcium phosphate to prepare calcium phosphate collagen composite particles, weighing the collagen composite particles and calcium phosphate powder, adding the collagen composite particles and the calcium phosphate powder into a collagen solution, adding a cross-linking agent for cross-linking, and carrying out freeze-drying molding. The preparation method obviously enhances the mechanical strength of the artificial bone repair material on the premise of ensuring excellent degradation performance and biological activity.

The invention relates to the technical field of biomedical materials, in particular to an artificial bone composite material and a preparation method thereof. The preparation method of the artificial bone composite material comprises the following steps: sequentially adding a CaCl2 solution and a NaH2PO4 solution into a collagen solution in proportion. And adjusting the pH value to 7.4, and collecting white jelly. Dispersing the white jelly in distilled water to obtain a colloid I; respectively adding the colloid I and the modified polyether-ether-ketone powder into a dichloromethane solution containing poly-L-lactic acid in proportion to obtain a mixed solution II, and then adding an ethanol solution for precipitation; and removing the precipitate in the mixed solution II to obtain the slurry. Injecting the slurry into a mold to obtain an intermediate I, and soaking the intermediate I in an EDC / NHS ethanol solution for crosslinking; according to the preparation method, the artificial bone composite material with high mechanical strength and good biocompatibility can be prepared, the defect that the biocompatibility and mechanical strength resistance of the artificial bone composite material cannot be obtained at the same time in the prior art can be overcome, and the practicability of the artificial bone composite material is improved.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention discloses a titanium alloy artificial bone abrasive flow machining grinding amount prediction method and device and a medium, and relates to the technical field of ultra-precision surface machining. The method comprises the following steps: constructing a grinding amount prediction model; the method comprises the following steps: constructing a titanium alloy right-angle elbow model; based on the titanium alloy right-angle bent pipe model, the right-angle bent pipe is machined multiple times through a one-way abrasive particle flow machine tool, a change curve of the grinding amount is obtained, numerical simulation is conducted on the change curve of the grinding amount, and a grinding amount correction coefficient function is obtained; and the grinding amount correction coefficient function is substituted into a grinding amount formula, a grinding amount removal prediction model is obtained, and based on the grinding amount removal prediction model, titanium alloy artificial bone abrasive flow machining grinding amount prediction is achieved. According to the method, the grinding amount removal prediction model is established on the basis of the grinding amount correction coefficient function, the grinding amount of titanium alloy artificial bone abrasive flow machining is effectively predicted, and the method can be suitable for abrasive flow polishing of complex curved surfaces.

The invention relates to a recombinant collagen bionic artificial bone and a preparation method and application thereof.The recombinant collagen is subjected to cross-linking modification, the molecular weight and viscosity of the recombinant collagen are increased, a fiber network structure is formed, then the calcium-phosphorus ratio of hydroxyapatite is simulated through soluble salts of calcium chloride and sodium dihydrogen phosphate, and the recombinant collagen bionic artificial bone is obtained. The biomimetic artificial bone can replace insoluble hydroxyapatite to mineralize the recombinant collagen, so that the utilization rate of the collagen is improved, and the obtained biomimetic artificial bone can exert a better osteogenesis effect. The obtained bionic artificial bone is high in biological safety, has high bionic characteristics, good biocompatibility and mechanical properties matched with human bones, can induce bone marrow mesenchymal stem cell osteogenic differentiation, and has great potential in the field of bone defect repair.

An artificial bone repair material and a preparation method therefor, and a preparation method for a porous magnesium-containing tricalcium phosphate powder for the artificial bone repair material. The artificial bone repair material is a composite material having a porous structure, and the raw materials of the artificial bone repair material comprise collagen and a porous magnesium-containing tricalcium phosphate powder, wherein the porous magnesium-containing tricalcium phosphate powder is formed by subjecting a precipitate obtained after the reaction of a calcium salt solution, a magnesium salt solution and a phosphate solution to spray drying, and the particle size of the magnesium-containing tricalcium phosphate powder is 1-20 μm. The mass percentage of magnesium-containing tricalcium phosphate in the artificial bone repair material is 50-95%. The artificial bone repair material has a relatively high ceramic component content, and the binding property and dispersity of the ceramic component in collagen are relatively good, such that the artificial bone repair material has relatively high biological activity and degradability, and the new bone tissue can grow inside until a bone defect part is completely replaced, while the artificial bone repair material is degraded in vivo.

The invention relates to a drug-loaded bone filling material, a preparation method thereof and application of the drug-loaded bone filling material in inhibition of relapse of opioid drugs. The drug-loaded bone filling material is prepared from the following raw materials: powder and curing liquid, the powder comprises a mixture of an opioid receptor antagonist and inorganic calcium salt; in the powder, the mass ratio of the opioid receptor antagonist to the inorganic calcium salt is 4-20%. After a performance test, the drug-loaded bone filling material has the advantages of proper coagulation time, good compressive strength and better drug sustained release characteristic, on one hand, artificial bones capable of promoting osteoblast differentiation can be filled in a bone defect area, and on the other hand, side effects caused by opioid drugs can be relieved, and symptoms can be relieved; meanwhile, for relieving opioid addicts, long-time drug action can be maintained, relapse can be prevented or reduced, and the pharmaceutical composition has great application potential in promoting osteoblast differentiation or inhibiting relapse of opioid drugs.

The invention discloses a ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method comprises the following steps: constructing an amphiphilic micelle system through a PEG-PLA (Polyethylene Glycol-Polylactic Acid) block copolymer, firstly preparing a micelle solution, then applying the micelle solution to precursor slurry preparation and PLGA pore-forming agent pretreatment (solving the problems of compatibility and agglomeration) in stages, molding and drying, and then carrying out gradient sintering (removing an auxiliary agent at low temperature and promoting densification at high temperature) to obtain the product. The method solves the problems of poor compatibility of a pore-forming agent and a precursor, powder agglomeration and uneven pore structure in a traditional process, and the obtained material has a three-dimensionally communicated and uniformly distributed micropore structure and is uniform in component.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

The invention provides coral hydroxyapatite as well as a preparation method and application thereof, the aperture of the coral hydroxyapatite is 30-1300 microns, the porosity is 50-70%, and the conversion rate is more than 50%. The preparation method comprises the following steps: soaking pretreated corallite in a cutting protective agent, cutting to obtain cut corallite, and screening the cut corallite meeting the cutting size requirement to obtain a cut corallite good product; and fully soaking the cut corallite good product with a phosphate solution, and carrying out a water heat exchange reaction to obtain the coral hydroxyapatite, the cutting protective agent is a solution containing polyol. According to the preparation method disclosed by the invention, the cutting efficiency can be obviously improved, the cutting specification and dimension can be widened, the product yield, particularly the yield of small-specification and dimension products, can be obviously improved, and the application range of the artificial bone is further widened.

The invention discloses an absorbable soft artificial bone material and a preparation method thereof, and relates to the technical field of medical materials. The absorbable soft artificial bone material comprises the following raw materials in parts by weight: 30-60 parts of bioactive glass, 20-50 parts of collagen, 10-30 parts of a reinforcing agent, 1-3 parts of an antibacterial agent, 5-10 parts of a pore forming agent and 100-180 parts of deionized water. The absorbable soft artificial bone material prepared by the invention has good compressive strength and fracture toughness and excellent antibacterial performance.

Provided are a preparation process for a modified hydroxyapatite and the use thereof. The preparation process comprises the following steps: S1. removing impurities from coral by using a sodium hypochlorite solution, followed by crushing to obtain coral particles; S2. subjecting the coral particles and a phosphate solution to a hydrothermal reaction at a pH value of 9-11 to obtain coralline hydroxyapatite; S3. mixing and reacting the coralline hydroxyapatite and an ion source to obtain an ion source-doped coralline hydroxyapatite; and S4. heating the ion source-doped coralline hydroxyapatite, and sintering and cooling same to obtain an ion source-doped coralline β-tricalcium phosphate, wherein the ion source comprises a strontium source. The modified hydroxyapatite prepared by the preparation process has a better degradation performance and mechanical adaptability, which improves the biological activity and osteoinductivity of coral artificial bones, and facilitates bone tissue ingrowth.

The invention discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof.The engineering construction composite artificial bone comprises a bioactive material and a mechanical supporting scaffold, the bioactive material serves as a main body, the mechanical supporting scaffold is contained in the bioactive material, and the bioactive material and the mechanical supporting scaffold are tightly combined to form an artificial bone tissue complex; the mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. The bone integration performance and mechanical performance of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

1. The name of the product of this design: Blister box (artificial bone paste mixing injection kit). 2. Purpose of the product with this design: The product with this design is used to contain artificial bone paste mixing injection kit. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

A simulated anatomical joint includes a first artificial bone having a first articular surface, a second artificial bone having a second articular surface matable to the first articular surface to simulate a natural joint, and artificial ligaments connecting the first artificial bone to the second artificial bone. The artificial ligaments connect the first artificial bone to the second artificial bone such that the first articular surface is proximate to the second articular surface. The artificial ligaments connected to the first artificial bone and second artificial bone are adjustable to simulate stresses in a natural anatomical joint corresponding to the first artificial bone and second artificial bone.

1. The name of the product of this design: packaging box (artificial bone repair material). 2. Purpose of this design product: This design product is used for packaging products. 3. The design key points of this appearance design product are: the combination of shape, pattern and color. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The design for which protection is sought includes color.

The invention discloses a cobaltosic oxide-carbon co-doped hydroxyapatite artificial bone material and a preparation method thereof, and belongs to the technical field of biomedical ceramic materials. According to the method, hydroxyapatite is used as a matrix, potassium hexacyanocobaltate is used as a cobalt source and carbon source precursor, cobaltosic oxide nanoparticles and a carbon phase are generated in situ through loading and staged gradient sintering in an inert atmosphere, and the artificial bone scaffold material is obtained through forming and degreasing. The cobaltosic oxide in the obtained material can refine grains and improve the mechanical strength, the in-situ carbon phase serves as a flexible toughening phase to reduce the brittleness, and the cobaltosic oxide and the in-situ carbon phase cooperate to achieve synchronous improvement of the strength and the toughness; and meanwhile, the precursor is pyrolyzed to produce gas and cooperatively form pores, so that a three-dimensional porous structure with excellent connectivity is formed. The preparation method is simple in process and good in dispersion uniformity, and the problems that pure hydroxyapatite is poor in mechanical property, high in brittleness, insufficient in pore connectivity and the like are solved.

The utility model discloses a positioning device for processing an artificial bone scaffold, which comprises a base, and a power component for driving a device to perform clamping motion is arranged on the base; the two clamping plates are symmetrically distributed in the base, the interiors of the two clamping plates are connected with rotating shafts through bearings, the rotating shafts and the rotating disc are installed together, the angle of the rotating shafts is controlled by rotating the rotating disc, and finally the machining angle of the support is controlled; a plurality of limiting holes which are annularly distributed are formed in a clamping plate, a limiting rod in a rotating disc can limit a limiting disc at multiple positions, the fixing angles of a support are more, machining of the support is facilitated, the support is clamped through cooperation of a first moving frame and a clamping semi-ring, the angle of the clamping semi-ring is adjustable, and the clamping efficiency is improved. And meanwhile, the positions of the first moving frame and the second moving frame are linked through gas in a three-way groove, so that the supports with the different shapes can be clamped conveniently.

The utility model relates to the technical field of medical instruments, in particular to a PEEK artificial bone material installation auxiliary instrument which comprises a face auxiliary limiting elastic cover used for conducting auxiliary limiting on PEEK artificial bone materials after face shaping and a nasal groove abutting device used for preventing nasal groove hyperplasia after nasal base filling. The face auxiliary limiting elastic cover comprises a cover body, a head circumference adjusting fastening belt and a top fixing belt, the cover body is matched with the human face structure, wearing ear through holes are reserved in the two sides of the cover body, a forehead through groove, an eyebrow bone eye through groove, a nose through groove and a lip through groove are sequentially formed in the cover body from top to bottom in a penetrating mode, and the forehead through groove is matched with the human forehead structure. The inner walls of the two sides of the forehead through groove are connected with forebone side face abutting plates with the postoperative forehead joint protruding. Through a plurality of fixing points and an adjusting mechanism, the stability and adaptability are improved, it can be ensured that the PEEK artificial bone material can be kept at an ideal position after an operation, the stability of an operation site is facilitated, the displacement risk is reduced, and the operation success rate is increased.

The application discloses a kind of ceramic artificial bone materials and preparation method thereof, belong to ceramic material preparation technical field.The method is constructed amphiphilic micellar system by PEG-PLA block copolymer, first preparation micellar solution, then it is used for precursor slurry preparation and PLGA pore former pretreatment (solve compatibility and agglomeration problem) in stages, after forming and drying, by gradient sintering (low temperature to aid agent, high temperature promotes densification) obtain product.The application solves the problem that pore former and precursor are compatible in traditional process, powder agglomeration, pore structure is uneven, and the obtained material has three-dimensional connected and uniformly distributed micropore structure, and uniform composition.

The invention relates to the field of material processing, and provides an injectable artificial bone repair material and a preparation method thereof.The injectable artificial bone repair material is prepared by screening and adjusting particle size distribution of calcium sulfate coarse powder and calcium sulfate fine powder and mixing the calcium sulfate coarse powder and the calcium sulfate fine powder to form mixed powder, the particle size of the calcium sulfate coarse powder is 20-100 micrometers, and the particle size of the calcium sulfate fine powder is smaller than or equal to 7 micrometers; the mass ratio of the calcium sulfate coarse powder to the calcium sulfate fine powder is (1: 0.25)-(1: 2). The liquid-solid ratio of the curing liquid to the mixed powder can be effectively reduced, microdefects of injectable slurry formed after the curing liquid and the mixed powder are mixed after curing are reduced, and after curing, the number of micropores is smaller, the structure is more compact, and the strength is higher.

The present invention discloses a mold and method for preparing a biomimetic bone radial gradient porous NiTi alloy, comprising the following steps: 1) mold design and assembly; 2) slurry preparation; 3) co-injection molding; 4) curing and drying; 5) degreasing and sintering; and 6) pore-forming agent removal. The biomimetic bone radial gradient porous nickel-titanium alloy prepared by the present invention has a relatively continuous porosity variation from 15% in the outer layer to a maximum of 70% in the inner layer, and an average pore size variation from 30 μm in the outer layer to over 400 μm in the inner layer. The mechanical properties are substantially matched to those of bone. The biomimetic bone radial gradient nickel-titanium alloy prepared by the method of the present invention can be used as an ideal artificial bone tissue repair or replacement material, and is suitable for directly preparing materials such as dental implants, artificial joints, and bone trauma products without the need for subsequent processing.

The application provides an artificial bone material and a preparation method thereof, wherein the material quality of the artificial bone material includes, with the total dry matter of the artificial bone material being 100%, 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen, and 0-7% of excipients. The artificial bone material provided by the application has high porosity and a longitudinal gradient structure, can simulate the characteristics of natural bone tissue, and has excellent biocompatibility, biodegradability, hydrophilicity, osteogenic performance and shape memory function.

A method for treating an artificial bone implant with blood, according to the method bone material is placed in a container configured to be filled with blood, wherein the container comprises an opening and a cover configured to cover the opening of the container and a fixed separator that separates a bottom part and an upper part. The separator is provided with holes so that when the container is filled with whole blood, the blood in the bottom part is in full contact with the blood in the upper part, and wherein the bone material is in the upper part, on top of the separator.

To provide an artificial bone having a porous structure with an improved affinity to osteogenic cells, an artificial bone (1) includes: a base material (2) containing porous ceramics provided with mutually interconnected multiple pores (6); a carbonaceous thin film (10) formed on an outer surface of the base material and wall surfaces (7) of the pores; and functional groups (13) including amino groups (12) provided on a surface and in an interior of the carbonaceous thin film.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.