14 results about "Artificial bone" patented technology

A method for treating an artificial bone implant with blood, according to the method bone material is placed in a container configured to be filled with blood, wherein the container comprises an opening and a cover configured to cover the opening of the container and a fixed separator that separates a bottom part and an upper part. The separator is provided with holes so that when the container is filled with whole blood, the blood in the bottom part is in full contact with the blood in the upper part, and wherein the bone material is in the upper part, on top of the separator.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

This utility model relates to the field of orthopedic implant technology and discloses a prosthesis for defects after partial atlas resection. It aims to solve the problems of existing technologies, such as the lack of atlas prosthesis implants, long recovery times after autologous bone grafting, and the ineffective fixation of titanium mesh implants. This utility model includes a prosthesis that replaces the atlas, with bone screw holes to accommodate bone screw fixation contact points. The prosthesis includes an outer frame, which is a porous tubular or porous columnar structure. The cavity of the porous tubular structure is filled with autologous bone, allogeneic bone, or artificial bone. The upper and lower ends of the outer frame are provided with curved surfaces matching the facet joints of the occipital condyle and axis, and a support unit is provided within the outer frame. This utility model, combined with 3D printing technology, matches the shape of the corresponding segment and resection site, thereby replacing the resected segment, promoting the fusion of the atlantoaxial segment, and facilitating the restoration of the physiological function of the upper cervical spine.

The utility model relates to medical instrument technical field, specifically disclose a skull repair device of integrated cerebrospinal fluid shunt, including artificial bone plate, be used for repairing skull defect, the outer surface of artificial bone plate is equipped with positioning recess, the positioning recess is used for accommodating cerebrospinal fluid shunt, and the positioning recess is equipped with the fixing assembly for fixing shunt. The utility model embeds the main part of cerebrospinal fluid shunt into artificial bone plate, makes shunt main part can accommodate in the thickness range of repair device itself, thereby significantly reduced the overall profile height of implant, effectively reduced the pressure and tension generated to scalp, can prevent the scalp erosion, breakage, necrosis and other serious complications caused by implant profile too high, simultaneously, through the fixing assembly to the shunt fixation, can effectively prevent the shunt from turning over or displacement after operation, guarantee the long-term stability and safety of drainage system, and simplify the operation.

This invention relates to the fields of biomedical engineering and intelligent manufacturing technology, and discloses a multi-objective optimization design method for biomimetic artificial bone based on machine learning, including the following steps: 1) image acquisition and three-dimensional model establishment; 2) structural partitioning and performance requirement allocation; 3) generation of composite TPMS units; 4) mesh generation and simulation preparation; 5) machine learning prediction and reverse design. This invention overcomes the shortcomings of existing single structures that cannot simultaneously meet the initial stability and long-term bone regeneration requirements of implants. Through a performance-driven gradient design strategy, the external bearing area and the internal growth area can achieve a natural transition in the same structure, avoiding structural abrupt changes and mechanically weak areas caused by traditional methods.

Methods, systems, apparatuses, and computer program products are described herein for printing artificial constructs or tissue models from a bioink using digital light processing (DLP). Bioinks can include polyethylene glycol diacrylate (PEGDA), gelatin methacrylate (GelMA), hyaluronic acid methacrylate (HAMA), lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), tartrazine, arginine-glycerine-aspartic acid (RGD), isoleucine-lysine-valine-alanine-valine (IKVAV), and Dulbecco's Phosphate-Buffered Saline (dPBS) pH buffered with calcium and magnesium. Such bioinks can result in printed constructs that exhibit improved vascularity / perfusability and improved stem cell growth and regulation. Bioink can be formed by vortexing a solution of PEGDA, GelMA, HAMA, LAP, tartrazine, RGD, IKVAV, and / or dPBS at a temperature of, e.g., about 60°C or greater. DLP bioprinting can be carried out layer-by-layer with an average thickness of each layer being between about 25 µm and about 100 µm. Average light intensity emitted during DLP bioprinting can be between about 10 mW / cm2 and about 30 mW / cm2.

This invention discloses a 3D-printed biodegradable drug-loaded artificial bone repair scaffold, belonging to the field of orthopedic implant technology. The scaffold adopts a gradient porous structure and biodegradable composite material, with internal through-holes and tapered interfaces on the surface, which can load drugs for sustained release. It also has functions of bone induction, anti-infection, mechanical support and prosthesis adaptation, and is suitable for individualized repair of large bone defects after bone tumor resection.

The application discloses a ceramic slurry for light-cured forming of artificial bone scaffolds and a preparation method thereof. The ceramic slurry comprises the following components: resin premix liquid 40-60 parts by volume; hydroxylated ceramic powder 40-65 parts by volume; and a dispersant, wherein the addition amount of the dispersant is 1.5-20 wt% of the mass of the ceramic powder. The hydroxylated ceramic powder comprises hydroxylated hydroxyapatite (HA), beta-tricalcium phosphate (beta-TCP) and biologically inert ceramic, and the mass ratio of the HA, beta-TCP and biologically inert ceramic is 4-7:1-3:1-4. The resin premix liquid comprises photosensitive resin monomer, plasticizer and photoinitiator, and the mass ratio of the photosensitive resin monomer and the plasticizer is 3-21:1-2. The mass percentage of the photoinitiator in the resin premix liquid is 0.5-2 wt%.

A device for treating an artificial bone implant with blood, the device comprising: a container configured to accommodate an artificial bone implant and to be filled with blood, the container comprising an opening; and a cover configured to cover the opening of the container. Five additional embodiments of the device and methods for using it are described herein.

The application discloses a synthetic method of a composite coating and application of the composite coating to a surface of an artificial bone, and belongs to the technical field of biomaterials.The synthetic steps of the composite coating are as follows: firstly, the artificial bone substrate is cleaned and subjected to oxygen plasma activation pretreatment; secondly, polyether ether ketone is dissolved in N-methyl pyrrolidone, mixed with tantalum-doped lithium zirconate nanowires and a dispersing agent, and subjected to ultrasonic treatment to form a coating slurry; the coating slurry is formed into a wet film on the substrate by dip-coating; and finally, the wet film is subjected to step-by-step heat treatment and solidification to obtain the composite coating.The preparation steps of the nanowires are as follows: zirconium ethoxide, tantalum ethoxide and lithium methoxide are used as precursors, and a precursor sol is obtained through a sol-gel reaction under the control of water quantity; the nanowires are grown through a hydrothermal reaction combined with a morphology directing agent; and finally, the nanowires are washed, dried and calcined to obtain the final product.The method has simple process, and the obtained coating has excellent biocompatibility, mechanical strength and potential bioactivity, is suitable for surface modification of an artificial bone implant, and can effectively promote bone integration.

The application provides a modified coral artificial bone material and a preparation method and application thereof. A coral-based three-dimensional support is used as a structure template, a graphdiyne functional layer is constructed on the surface of the three-dimensional support to obtain a stable bioactive interface, and an HA in-situ mineralization layer is optionally further constructed, so that a surface modification system with osteogenic activity and adjustable interface mineralization behavior is formed, and an artificial bone material with a three-dimensional porous structure, osteogenic-related bioactivity and mechanical support stability is obtained. The artificial bone material has strong bionicity, superior mechanical properties, enhanced osteogenic activity, mild and controllable preparation process and wide application range, and provides a solution for complex weight-bearing repair requirements such as large-size bone defects.

This invention relates to a malleable collagen-based artificial bone repair material, its preparation method, and its applications, belonging to the field of biomedical materials technology. The invention designs a method for preparing the malleable collagen-based artificial bone repair material, obtaining a bone repair material with excellent water absorption, malleability, and workability. The softening conditions of the bone repair material are not limited; room-temperature physiological saline is sufficient to soften the material, eliminating the need for additional treatments such as heating. The method of use is simple, and it can be used in dental and orthopedic defect repair surgeries, with a wide range of indications.