607 results about "Bioceramic" patented technology

The present invention discloses novel polymer-ceramic matrix composites and processes for making same. The composites can be used in biomedical applications, in particular, coatings of implants and other medical devices, where both the ceramic phase and the polymer phase are bio-compatible. The composites combine a reinforcing polymer phase with a continuous ceramic matrix to create materials with properties that are new and superior to polymer or ceramic phases alone. The composites can incorporate a bioactive agent.

Porous bioabsorbable, bioactive and load-bearing composite medical device structure includes a plurality of regular textile planar layers (1a, 1b . . . ) formed of continuous bioabsorbable polymer matrix and bioceramic fibers acting as reinforcements, both included in continuous fibrous elements (3) forming the textile layers. The layers are placed on top of each other to form a structure having two dimensions (x, y) at right angles to each other according to the two dimensions of the textile layer and a third dimension (z) perpendicular to them and resulting from the piling of the layers. A plurality of passages extend through the layers as a result of the openings (2) defined by portions of the continuous fibrous elements (3) extending substantially in the direction of the plane. The continuous fibrous elements (3) comprise both bioactive ceramic reinforcing fibers which form a reinforcing structure and a bioabsorbable polymer matrix material which forms a matrix which binds the layers together and also binds the portions of continuous fibers defining the openings together, thereby forming the passages and stiffening the structure. This bioactive and bioabsorbable composite structure is suitable to be used as a basic structure in medical devices, especially in osteochondral applications where the load-bearing properties of implant are required.

A malleable bone graft composition is described. The composition comprises: (a) keratose; (b) particulate filler; (c) antibiotic; and (f) water. The invention may be provided in sterile form in an container, and optionally lyophilized. Methods of treating a fracture with such compositions are also described.

Compositions and materials for making soft suture anchors comprising materials that improve osteointegration have been developed. These compositions and materials comprise bioceramics, resorbable materials, and combinations thereof. A preferred embodiment comprises a soft suture anchor comprising a resorbable ceramic and a resorbable suture.

The present invention relates to a controllably-released bioceramic thrombus filter and its preparation method. Said thrombus filter is made up by using laser engraved metal tube, its end portion is equipped with a combination portion matched with a conveying portion, its centre is equipped with an elastic wire and its surface is convered with a layer of bioceramic membrance. It can be temporarily placed into blood vessel of human body, also can be permanently placed in the blood vessel of human body. Said invention also provides the concrete working principle of said thrombus filter.

Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.

The invention discloses a preparation method of gradient porous bioceramic scaffold. The method adopts the steps of preparing three-dimensional shells, pouring bioceramic slurry, freeze-drying and sintering to prepare porous bioceramic scaffold with relatively dense structure in the exterior and directional layered porous structure in the interior. The average flexural strength of the shell material reaches 28.5-35.6MPa; in addition, the porous bioceramic scaffold prepared by the method of the invention can be customized according to the individual differences of patients without relying on moulds for shaping and the invention is characterized by fast production; and the gradient porous bioceramic scaffold can be used in the field that artificial bone is used to repair pathological or injured bone tissues.

Methods and devices relating to polymer blend/bioceramic composite implantable medical devices are disclosed.

The invention relates to a CaP (Calcium Phosphate)/collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg/ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.

The present invention relates to a process for preparing hydroxylapatite bio-ceramic membranes at titanium or titanium alloy surfaces by utilizing differential arc oxidation process. Firstly, preparing electrolytic solution A by using calcium ion salts and phosphate radical ion-containing salts, or preparing electrolytic solution B by adding metal silver ions to the electrolytic solution A; or preparing electrolytic solution C by adding metal silicon ions to the electrolytic solution A; and then, selecting titanium or titanium alloy as anodes and putting them respectively into the electrolytic solution A, B and C, selecting the non-corrodible steel container for containing the electrolytic solutions as cathodes, controlling conditions such as impulse electrical source positive phase voltage, frequency for differential arc oxidation of titanium or titanium alloy, then hydroxylapatite bio-ceramic membrane layers possessing different performances are prepared. Said titanium based bio-ceramic compound material prepared according to said process possesses not only intensity and toughness of metals but also biological activity of hydroxylapatites, and is capable of being applied in the fields such as jackstraw chirurgery implantation body and tooth planting body.

The invention is porous calcium phosphate ceramic material and the manufacturing method. It takes the calcium source and phosphate source according to Ca/P=1.00í½2.00/1.00 and computes the quantity of water according to the mol ratio Ca/H2O=1.00.3.00í½20.00, the hole agent/Ca=0.011í½6.00/1.00. adds in 0.1í½2.0mm hole agent, upgrades the temperature to 50í½1000íµ fro about 0í½24 hours, and carries on hydro-thermal process. The parameters are: pH is 5í½14, temperature 140í½360íµ, pressure 0.4í½20MPa, the insulated time 0í½24 hours.

The invention relates to a kind of hydroxyl apatite - zirconia compound biology ceramic material and its producing method, belonging to biology medical material producing technological field. The invention makes zirconia as substance central layer, on its upper and lower surfaces, respectively spread mix middle layer of zirconia and hydroxyl apatite mixed as per different proportion, on the most outside spread a surface layer of pure hydroxyl apatite, to form a kind of gradient nappe structure; in steel mould, at pressure of 10 - 30 MPa, dry press to molding, then at high temperature of 1500 - 1600 Deg. C, sinter without pressure, then can get hydroxyl apatite - zirconia compound biology ceramic material. The compound material produced by the method of the invention, its anti-bending strength is 900 - 1100 MPa, its fracture toughness (KIC) is 7 - 10 MPaíñm1/2, its roughness is 0.5 - 5.0 micron; the compound material has good biology compatibility, so can meet the requirement of load bearing planting body of different parts of human body.

A method of replacing an ACL with a graft. The method provides for the drilling bone tunnels in a femur and a tibia. A replacement graft is provided having first and second ends. A biodegradable composite screw is provided. The screw is made from a biodegradable polymer and a bioceramic or a bioglass. At least one end of the graft is secured in a bone tunnel using the biodegradable composite screw.

The invention relates to a calcium silicate/hydroxylapatite composite biological ceramic material and a preparation method and application thereof, belonging to the field of biological materials. Calcium silicate/hydroxylapatite nano composite powder prepared by a chemical method is used as a raw material and carried out the dry pressing and molding to obtain a material biscuit, and the biscuit is calcined at 1000-1200 DEG C for 1-10 hours to obtain a degradable calcium silicate/hydroxylapatite composite biological ceramic material which has good mechanical properties and is used for repairing the defects of hard tissues. The biological activity, the degradability and the mechanical strength of the biological ceramic material of the invention can be adjusted and controlled. The invention has simple and easy processes and convenient popularization.

The invention discloses a porous calc silicate bioceramic material, a preparation method and application. The porous bioceramic material comprises the following components in an oxide form in percentage by weight: 44 to 52 percent of CaO, 47 to 54 percent of SiO2, 0 to 3.0 percent of B2O3, 0 to 3.4 percent of ZnO and 0.2 to 4.8 percent of MgO, wherein the content of B2O3 and ZnO is not simultaneously 0; the ratio of the content of MgO and the content sum of B2O3 and ZnO is 1:(0.2-5). The preparation method comprises the following steps: preparing boron, zinc and magnesium-containing calc silicate superfine powder by using a wet-chemical method and a sol-gel method, preparing a porous material of which the shape is consistent with that of a skeleton of each part of a human body and the pore passage size is 80 to 800[mu]m by using a three-dimensional printing technology, and performing high-temperature sintering treatment. The material can be applied to the bone defect repair and bone regeneration medicine of the department of orthopedics, department of stomatology, plastic surgery, maxillofacial surgery, thoracic surgery department or ophthalmology department.

The invention includes a synthetic bone substitute material suitable for use as a replacement for cancellous bone in a bone graft composition, the material comprising a reticulated framework of interconnecting bioceramic struts defining an interconnecting interstitial void volume, and a solid non-porous composition substantially filling the interstitial void volume and in intimate contact with the reticulated framework, the pore-filling composition comprising calcium sulfate. Calcium triphosphate is a preferred bioceramic material for the reticulated framework.

Aiming at the problems of low strength and low toughness of bioactive ceramics, the invention provides a method for strengthening and toughening a bioactive ceramic material by use of graphene and preparing graphene/biological ceramic artificial bone by a selective laser sintering (SLS) technology. The method has the advantages that graphene is added into the bioactive ceramic (hydroxylapatite, calcium phosphate, bioglass, calcium silicate and the like) as a nano enhanced phase, and the strength and toughness of the ceramic can be remarkably improved by use of the excellent mechanical property of graphene; the SLS technology is applied to the preparation process of graphene/biological ceramic artificial bone, and the sintering time can be shortened to the second level and even millisecond level by use of the characteristic of quick heating and cooling of laser so as to avoid structural injury of graphene caused by long-time high-temperature effect. The method for strengthening and toughening the ceramic material by use of graphene provided by the invention is of great significance to the application of bioactive ceramic to the load bearing parts of the human body.

The present invention discloses the preparation process and apparatus for nanometer porous bioceramic. Slurry with nanometer structure is synthesized and centrifugally separated to form thick slurry; the thick slurry is added with foaming agent and formed into the initial blank; the initial blank is plasticized, and microwave sintered at 800-1400 deg.c for 0.5-30 min in the temperature raising rate of 25-200 deg.c/min; and the sintered product is cooled in the temperature lowering rate of 50-200 deg.c/min to room temperature to obtain the bioceramic product with nanometer structure. The preparation process is fast, simple and cheap, and the prepared bioceramic material has high bioactivity and high mechanical performance.

An implant composite material is provided which is for use in the treatment of articular cartilage disorders such as hip joint femur head necrosis and knee joint bone head necrosis, the reconstruction/fixing of a bio-derived or artificial ligament or tendon, the uniting/fixing of a bone, etc. Part of the implant composite material is replaced by bone tissues in an early stage to enable the material to stably bond with a living bone, while the other part retains a necessary strength over a necessary time period. Finally, the implant composite material is wholly replaced by the living bone and disappears.

It is an implant composite material having a constitution which comprises a compact composite of a biodegradable and bioabsorbable polymer containing bioabsorbable and bioactive bioceramic particles and a porous composite of a biodegradable and bioabsorbable polymer containing bioabsorbable and bioactive bioceramic particles, the porous composite being united with the compact composite. The porous composite is replaced by bone tissues in an early stage to enable the material to stably bond with a living bone, while the compact composite retains a necessary strength over a necessary time period. Finally, the material is wholly replaced by the living bone and disappears. Consequently, this implant composite material can sufficiently meet desires in this medical field.

The present invention is directed to a novel poly (diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.

The invention relates to a porous bioceramic with calcium phosphate nanorods on the surface layer and a formation method for the same, belonging to the field of biomaterial. In the method, the porous bioceramic with calcium phosphate nanorods on the surface layer is formed by hydrothermal process, and the calcium phosphate nanorods on the surface layer of the porous bioceramic are formed by extensional growth on the substrate surfaces with same or similar chemical compositions of calcium phosphate porous ceramic. Therefore, the calcium phosphate nanorods obtained on the surface of the porous bioceramic are closely and integrally connected with the substrates of the calcium phosphate porous ceramic. Compared with traditional calcium phosphate porous ceramic, the porous bioceramic formed by the method disclosed by the invention is high in bioactivity and mechanical strength; moreover, the formation method is simple, high in repeatability and capable of realizing large-scale production.