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Porous bioceramic with calcium phosphate nanorods on surface layer and formation method for same

A technology of bioceramics and porous ceramics, applied in the fields of bioceramics and its preparation, porous bioceramics, and the composition of porous bioceramics. Ceramic bonding is weak and other problems, achieving high repeatability, avoiding mechanical strength, and simple method

Inactive Publication Date: 2012-06-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation method also has some disadvantages
The biggest disadvantage is that the newly formed bone-like apatite layer on the surface has a weak bond with the base ceramic, and it is easy to separate from the base ceramic and fall off.
In addition, these formed bone-like apatite layers, in fact, will naturally form a bone-like apatite layer after being implanted in the body, so such a surface modification process has no practical significance

Method used

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  • Porous bioceramic with calcium phosphate nanorods on surface layer and formation method for same
  • Porous bioceramic with calcium phosphate nanorods on surface layer and formation method for same
  • Porous bioceramic with calcium phosphate nanorods on surface layer and formation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The reaction vessel used is a hydrothermal reaction kettle.

[0028] Prepare a 0.8 mol / liter aqueous urea solution in a hydrothermal reactor, and mix the prepared urea aqueous solution with 0.167 mol / liter Ca(NO 3 ) 2 4H 2 O and 0.1 mol / L (NH 4 ) 2 HPO 4 Mix to obtain a mixed solution, the Ca:P ratio of which is 1.67, then use nitric acid and ammonia water to adjust the pH of the prepared mixed solution to 4, and add 2 cm in diameter and 0.5 cm in thickness to the mixed solution after the pH value is stable. , a porous ceramic whose component is hydroxyapatite, undergoes a hydrothermal reaction at a temperature of 120° C. for 10 hours, and obtains a porous ceramic with hydroxyapatite nanorods on the surface. Wherein the average diameter of calcium phosphate nanorods is 60 nanometers, and the average length is 1200 nanometers, such as figure 2 The surface layer shown is a SEM photograph of a porous biohydroxyapatite ceramic with apatite nanorods.

Embodiment 2

[0030] A 0.2 mol / L aqueous urea solution was prepared in a hydrothermal reactor, and the other preparation conditions were the same as in Example 1 to obtain a porous ceramic with hydroxyapatite nanorods on the surface. Its hydroxyapatite nanorods have an average diameter of 50 nanometers and an average length of 1000 nanometers.

Embodiment 3

[0032] A 1.0 mol / L aqueous urea solution was prepared in a hydrothermal reactor, and the other preparation conditions were the same as in Example 1 to obtain a porous ceramic with hydroxyapatite nanorods on the surface. Its calcium phosphate nanorods have an average diameter of 55 nanometers and an average length of 1100 nanometers.

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Abstract

The invention relates to a porous bioceramic with calcium phosphate nanorods on the surface layer and a formation method for the same, belonging to the field of biomaterial. In the method, the porous bioceramic with calcium phosphate nanorods on the surface layer is formed by hydrothermal process, and the calcium phosphate nanorods on the surface layer of the porous bioceramic are formed by extensional growth on the substrate surfaces with same or similar chemical compositions of calcium phosphate porous ceramic. Therefore, the calcium phosphate nanorods obtained on the surface of the porous bioceramic are closely and integrally connected with the substrates of the calcium phosphate porous ceramic. Compared with traditional calcium phosphate porous ceramic, the porous bioceramic formed by the method disclosed by the invention is high in bioactivity and mechanical strength; moreover, the formation method is simple, high in repeatability and capable of realizing large-scale production.

Description

technical field [0001] The invention relates to a bioceramic and its preparation technology, in particular to a porous bioceramic with calcium phosphate nanorods on the surface layer and a method for forming the porous bioceramic, belonging to the field of biomaterials. Background technique [0002] Calcium phosphate porous ceramics have good biocompatibility, osteoconductivity, and osteoinductivity due to their chemical composition similar to human hard tissue and porous structure. Because of these biological properties, calcium phosphate porous ceramics have been widely used clinically as bone defect repair materials. However, due to the limitation of the preparation method, the porous calcium phosphate ceramics currently used are all constructed from huge calcium phosphate particles, and the diameter of the particles is usually greater than 1 micron. Such huge particles directly reduce the specific surface area of ​​ceramics, thereby reducing the bioactivity of ceramics....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B41/85A61L27/40A61L27/56
Inventor 洪友良王哲张兴栋
Owner SICHUAN UNIV
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