102results about How to "Easy to get" patented technology

The invention relates to the technical field of synthesis of antibody-coupled drug linkers, in particular to a synthesis method of MC-Val-Cit-PAB. The synthesis method comprises the following steps: carrying out amide condensation reaction on L-citrulline and M1 to form M2; carrying out amide condensation reaction on L-valine and M3 to form M4; and carrying out amide condensation reaction on M2 and M4 to form M5. The synthesis method improves the problems of low product purity, high initial raw material cost, low reaction conversion rate and the like in the existing synthesis method.

The application discloses a novel proton battery positive electrode material and a preparation method thereof. Iron source solution and phosphorus source solution are respectively prepared through an organic solution, and then the two solutions are mixed to perform a solvothermal reaction. After that, the product obtained in the reaction is washed and dried to obtain the novel proton battery positive electrode material. The material can be used to prepare a proton battery positive electrode sheet. The novel proton battery positive electrode material prepared by the application is a nanoparticle, the main component of which is iron phosphate. The particle morphology is uniform, and the specific surface area is large. The size of the particle is 50.0-200.0 nm. The proton battery prepared by using the novel proton battery positive electrode material has good electrochemical performance. The preparation method provided by the application is simple in process, raw materials are easy to obtain, and is suitable for large-scale industrial production.

The invention relates to the technical field of metal materials, and discloses a shape memory alloy film and a preparation method and application thereof. The shape memory alloy film comprises the following components: 50-55 at.% of Ni, 40-45 at.% of Ti, 3-5 at.% of Cu and 2-4 at.% of M, and M is selected from one or more of Zr, Hf and Nb. The shape memory alloy film has remarkable superelasticity, the recoverable strain of the shape memory alloy film can reach 8% or above, meanwhile, the compressive yield stress exceeds 1.5 GPa, and the shape memory alloy film shows excellent cycle stability. The preparation method is simple in process and high in controllability, a new scheme is provided for solving the problem of unstable performance of an existing NiTi-based film, and the preparation method is particularly suitable for high-performance micro devices such as a micro electro mechanical system.

The utility model relates to the technical field of rubber band guns, in particular to a folding rubber band gun which comprises a gun body left side plate and a gun body right side plate, a plurality of connecting grooves are formed in the inner side of the gun body left side plate and the inner side of the gun body right side plate, and a plurality of connecting pieces matched with the connecting grooves are arranged between the gun body left side plate and the gun body right side plate. A gun bolt trigger is arranged between the gun body left side plate and the gun body right side plate, and inserting holes are formed in the inner side of the gun body left side plate and the inner side of the gun body right side plate. According to the utility model, through the arrangement of the storable assembly, the handle middle piece and the handle side piece can be conveniently stored between the gun body left side plate and the gun body right side plate, the overall size is reduced, the storage is convenient, and through the matched arrangement of the trigger groove and the bolt trigger, the bolt trigger can be conveniently positioned and guided in the storage process; and the button for realizing storage adopts the rubber band as a reset power source, so that compared with a spring and the rubber band, the rubber band is easier to obtain and is not easy to lose.

The invention belongs to the technical field of heavy metal pollution treatment, and discloses a method for reducing soil cadmium activity and wheat grain cadmium content. According to the method, the low-cadmium-accumulation wheat variety is selected, the composite conditioner is applied, the low-cadmium-accumulation wheat variety is Jimai 22, and the composite conditioner is composed of mineral source potassium fulvate and zinc fertilizer. The complex passivation effect of humic acid components in mineral source potassium fulvate on soil heavy metal is utilized, the ion antagonism effect of zinc and cadmium and the low cadmium accumulation characteristic of Jimai 22 are combined, the cadmium content of wheat grains is synergistically reduced to 0.1 mg / kg or below, meanwhile, the cadmium content of the soil can be remarkably reduced, and the soil with cadmium exceeding the standard can be repaired. The treatment method provided by the invention has the advantages of simple operation, easily available raw materials, low cost, stable synergistic cadmium reduction effect and the like.

The application provides a multifunctional therapeutic instrument for migraine relief, which comprises a treatment frame, a slidingly installed mounting seat arranged on the treatment frame, a first hot compress pad arranged on the mounting seat, a fixed shell arranged on the treatment frame, a connecting hole arranged on the fixed shell, a movable frame arranged in the fixed shell, a connecting shaft arranged on the movable frame, the connecting shaft being rotatably arranged in the connecting hole, a sliding frame arranged in the movable frame, a mounting rod slidably arranged in the sliding frame, a pressing plate hingedly arranged at one end of the mounting rod, and a second hot compress pad arranged on the bottom surface of the pressing plate. The therapeutic instrument can effectively relax the tense muscles and nerves of the head and neck through the form of hot compress on the back of the neck and the forehead, so as to achieve the effect of relieving migraine, and the position of the hot compress pad can be conveniently adjusted for different people, and the hot compress pad is not easy to be separated.

The application discloses a method for treating antibiotic wastewater by using a graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate, and the method is characterized by using the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst to activate persulfate for degrading and treating antibiotic wastewater, wherein the graphdiyne / ferrous indium sulfide nanocomposite comprises ferrous indium sulfide nanoparticles, and the nanoparticles are loaded with graphdiyne nanosheets. The method for treating antibiotic wastewater by using the graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate uses the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst, wherein the nanocomposite has many reactive sites, high catalytic activity and good stability, can efficiently activate persulfate with a smaller amount of catalyst, can efficiently remove antibiotics in wastewater, and has the advantages of low cost, high treatment efficiency, good removal effect, green environmental protection and the like, and therefore, the method has important significance for effectively purifying antibiotic wastewater, has high use value and good application prospect.

This invention relates to the field of detection, specifically to a blank blood matrix, which is a mixed solution containing hemoglobin, serum protein, pH adjuster, stabilizer, surfactant, and phosphate buffer; wherein the concentration of hemoglobin is 20%-60% (m / v), the concentration of serum protein is ≤20% (m / v), the concentration of stabilizer is ≤10% (m / v), the concentration of surfactant is ≤0.5% (m / v), and the concentration of pH adjuster is ≤0.5% (m / v). This invention provides a fully compounded blank blood matrix, which, based on the combined control of components and proportions, achieves synergy and can well simulate whole blood. Furthermore, it is essentially free of endogenous target substances such as amino acids, carnitine, organic acids, hormones, fatty acids, vitamins, neurotransmitters, or drugs, thus combining excellent whole blood simulation with low matrix effects.

This invention discloses a heterogeneous composite electrode material, which uses nickel foam as a carrier and forms a Ni3S2 / MnS heterogeneous composite material with a heterogeneous interface structure on the surface of the nickel foam. Fe is doped into both the Ni3S2 and MnS lattices of the Ni3S2 / MnS heterogeneous composite material. This heterogeneous composite material exhibits good catalytic performance and stability. This invention also provides a method for preparing the heterogeneous composite electrode material, which is simple, suitable for large-scale production, uses low-cost raw materials, and requires simple equipment, making it economical. Furthermore, this invention discloses an application of the above-mentioned heterogeneous composite electrode material in the field of alkaline water electrolysis.

The application discloses a product environment stress estimation method, system, device and storage medium, which is applied to the product evaluation technical field and comprises the following steps: receiving environment stress time series data of a measured product at each set detection position collected by a sensor; determining each stress extreme position and an environment stress value of the measured product under a determined working condition; constructing a Kriging model; inputting physical size information of the measured product, coordinate information of each set detection position, environment stress time series data, coordinate information of each stress extreme position and the environment stress value into the Kriging model and performing interpolation through grid division to obtain each environment stress field matrix of the measured product output by the Kriging model in time sequence, and determining an environment stress value of a target position at a target time. According to the scheme, the environment stress at each position of the measured product at each time can be conveniently and effectively estimated, and the accuracy is relatively high.

The application relates to the field of battery replacement cabinets, and discloses an intelligent automobile battery replacement cabinet of a heat dissipation type shared battery. The cabinet body is provided with a shielding frame at the upper end, a plurality of charging compartments are formed in the front side of the cabinet body, a sealing door is arranged at the front side of each charging compartment, and a battery rack is fixedly connected in each charging compartment. A battery moving mechanism is arranged in each battery rack, the battery moving mechanism comprises a sliding supporting seat which is slidably arranged at the bottom of the battery rack, a mounting strip is fixedly connected in the battery rack, and an electric telescopic rod is arranged on one side of the mounting strip. In the use process of the battery replacement cabinet, compared with the existing inclined charging compartment cabinet body, the scheme can facilitate the taking and taking operation on the basis of ensuring the tightness of the electrical connection, effectively avoid the contact of rainwater with the charging electric contacts, can also perform water absorption and drying treatment on the electrode part of the battery to be charged, and the practical effect in rainy days is ensured.

A structure in which an effective visual field of a person can be detected is achieved. A visual-line-movement-related-value-acquisition device 220 comprises a database configured to store a relationship between the subject's visual line movement-related value and the coordinated motion-related value in advance, and configured to acquire a subject's visual line movement-related value when a coordinated motion-related value is a predetermined value from the database by using a relationship between the acquired subject's visual line movement-related value and the acquired coordinated motion-related value, to thereby acquire an index related to an effective visual field of the subject.

This invention discloses a method for synthesizing an intermediate of retinoic acid, relating to the field of pharmaceutical organic synthesis technology, comprising the following steps: S1, in the presence of a base, 2-amino-3-chloropyridine and 4-bromopiperidine undergo a nucleophilic substitution reaction in solvent A to prepare compound III; S2, in the presence of a catalyst and ammonia solution, compound III undergoes an amination reaction in solvent B to prepare compound II; S3, compound II is dissolved in solvent C, and sequentially undergoes CDI cyclization and hydrogen chloride solution salt formation to prepare compound I, namely 1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one. This invention is low-cost, uses mild reaction conditions, has a simple synthesis process, high yield, and eliminates the need for expensive and potentially unsafe excipients, effectively improving reaction safety, being environmentally friendly, and suitable for industrial production.

The application discloses a kind of based on inflation plate's spray type liquid cooling battery energy storage cabinet and control method, including energy storage cabinet cabinet and heat management module, the battery pack containing electric core is placed in the energy storage cabinet cabinet inside, spray cooling module, fire-fighting module, control module and energy storage converter module;It also discloses a kind of control method simultaneously, so that electric core works at optimum temperature, guarantees electric core safety, prolongs electric core life;Adopt spray liquid cooling mode, contact thermal resistance is lower, surface temperature uniformity is better;Each module is using module integration design, space structure is compact, installation mode is simple, flexibility is high, adapts to different size energy storage battery pack.

The application discloses a preparation method of high-strength and high-ductility titanium-based composite material with a composition gradient, and comprises the following steps: 1, material selection: selecting a plurality of Mo equivalent different beta type titanium alloy powder as a matrix material, and selecting carbon nanoparticles as a precursor material of a reinforcing body; 2, powder mixing: placing the plurality of Mo equivalent different beta type titanium alloy powder and the carbon nanoparticles in a ball mill and ball milling and uniformly mixing; 3, forming: performing plasma sintering forming on the mixed powder; 4, heat treatment: performing solid solution treatment on a titanium-based composite material blank to obtain the high-strength and high-ductility titanium-based composite material with the composition gradient. The application utilizes a powder metallurgy method to sinter the plurality of Mo equivalent different beta type titanium alloy powder and the carbon nanoparticles into a bulk alloy, so that the sintered bulk alloy has the composition gradient, and the prepared titanium-based composite material with the composition gradient has excellent mechanical properties and is a high-strength and high-elongation composite material.

The present application relates to a kind of palladium-based methane combustion catalyst and its preparation method and application, the preparation method includes the following steps: after obtaining mixed sol by mixing titanium source, cerium source and complexing agent, evaporate, dry and sinter in sequence, obtain cerium titanium carrier;The palladium-based methane combustion catalyst is obtained by impregnating mixed cerium titanium carrier and palladium source, and then drying and calcining in sequence.The preparation method of the present application is simple, and raw materials are cheap and easy to obtain.The palladium-based methane combustion catalyst prepared has low light-off temperature, and has water resistance, which can be applied to the treatment of methane in tail gas.

This invention belongs to the field of solar water evaporation technology, and discloses a high-efficiency solar water evaporator, its preparation method, and its application. The preparation method includes the following steps: (1) Clean and dry coconut fibers, take multiple coconut fibers and weave them into a rope, and then cut them into coconut fiber ropes of the same length; (2) Embed the above-mentioned coconut fiber ropes of the same length into a sponge in an m×n array, wherein the lower end of the coconut fiber rope is flush with the bottom surface of the sponge, while its upper end protrudes from the top surface of the sponge by a certain height; (3) Immerse the part of the above-mentioned coconut fiber rope array protruding from the top surface of the sponge in a sodium alginate solution containing carbon black for surface coating treatment, and then take it out and air dry naturally to obtain a high-efficiency solar water evaporator based on a coconut fiber array. This invention has the characteristics of wide material sources, low cost, simple evaporator construction method, and high water evaporation rate, and has better prospects for large-scale preparation and commercial application.

This invention discloses a cell sample viability detection kit and method based on mass spectrometry flow cytometry. The cell sample viability detection kit based on mass spectrometry flow cytometry includes separately packaged solutions C, P, Pd, F, M, and D; solution C includes bovine serum albumin and phosphate buffer; solution P includes phosphate buffer; solution Pd includes palladium dichloride and double-distilled water. The effective component of palladium dichloride, palladium, has the following natural isotope abundances: isotope 102 The relative abundance of Pd was 1.02%. 104 Pd was 11.14%. 105 Pd is 22.33%. 106 Pd is 27.33%. 108 Pd was 26.46%. 110 Pd is 11.72%; Solution F includes paraformaldehyde and phosphate buffer; Solution M includes methanol; Solution D includes... 191 / 193 Ir, paraformaldehyde, and phosphate buffer. This invention's kit features high detection sensitivity, reduced detection interference, improved experimental efficiency, and reliable results.

The invention relates to a furosemide tablet and a preparation method thereof.The furosemide tablet is prepared from, by weight, 25.00% of furosemide, 40%-45% of filler, 27%-33% of adhesive, 0.5%-1.5% of lubricant, 1.0%-2.0% of anti-sticking agent and 0.5%-1.5% of flow agent.The furosemide tablet is prepared by adopting the technology that purified water is directly added without preparing the adhesive; a wet granulation process is adopted, the controllability of process parameters in the production process is high, the human influence of operation of multiple process steps is reduced, the quality stability of the medicine is effectively improved, the quality of the medicine is equivalent to that of a commercially available reference preparation, and multiple dissolution curves are similar to that of the reference preparation; the in-vitro dissolution behavior similar to that of a reference preparation is shown, the quality is stable, and the dissolution behaviors among batches are consistent.

The application belongs to the technical field of chemical analysis, and particularly relates to a detection method for D-glycophosphocholine content in L-alpha-glycophosphocholine and application. The detection method selects a silica gel surface polysaccharide covalent bonding cellulose type or silica gel surface polysaccharide coating cellulose type normal phase chromatographic column and an evaporative light scattering detector (ELSD), detects through an HPLC-ELSD method, has the advantages of simple operation, high sensitivity, good method specificity and reproducibility, is a high-efficiency liquid phase analysis method convenient for standardized operation, can completely separate L-alpha-glycophosphocholine from low-limit D-glycophosphocholine isomer impurities, and can accurately quantify.

This invention discloses a method for preparing a self-healing hydrogel with both sensing and antibacterial properties. The invention uses a hydrogel prepared from acrylamide (AM) and 2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) and cellulose nanofibers (CNF) as a matrix, silver-coated polydopamine nanoparticles (Ag@PDA NPs) as antibacterial and conductive agents, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylphenylacetone (I2959) and polyethylene glycol diacrylate (PEGDA) as photoinitiators and crosslinking agents. A multifunctional hydrogel with multiple dynamic reversible bonds is prepared by ultraviolet light-initiated self-polymerization. By constructing various dynamic reversible interactions, including covalent and non-covalent bonds and interionic interactions, a self-healing Ag@PDA NPs / AM / SBMA / CNF hydrogel was obtained. Ag and DA were introduced to prepare Ag@PDA with antibacterial, adhesive, and electronic conductivity properties, while zwitterionic SBMA was introduced to provide ionic conductivity. The synergistic effect of these two compounds endows the hydrogel with electrical conductivity. The hydrogel dressing prepared by this method can achieve rapid sterilization while possessing excellent biocompatibility, high adhesion, high conductivity sensing ability, and environmental adaptability.

The electric heating device of the present invention includes a heating panel, a heating element, a heat insulation component, a fixing shell, a temperature measuring element, and a socket. The heating element is located on the lower side of the heating panel and has a power receiving part. The heat insulation component has a heat insulation cavity with an upper opening for covering the heating element. The fixing shell has a shell cavity with an upper opening for accommodating the heat insulation component, and the upper end of the fixing shell is connected to the heating panel by an adhesive material. The temperature measuring element is installed at the bottom of the heat insulation component. The socket is fixed to the side of the fixing shell and electrically connected to the power receiving part and the temperature measuring element respectively through a power supply wire and a detection wire. The power supply wire is arranged in a power supply groove, and the detection wire is arranged in a detection groove. The interface end of the socket faces the side of the fixing shell. By providing a socket on the fixing shell, external wiring can be quickly connected to the socket of the electric heating device through a plug during assembly. This assembly method is simple, quick, reliable, and interchangeable, achieving modular packaging and good overall product integrity.

The invention relates to the field of carbonate polymerization, and discloses isosorbide polycarbonate and a preparation method thereof. The preparation method of the isosorbide polycarbonate comprises the following steps: under the action of a ketonic acid metal salt catalyst, taking a dihydroxy compound, diester carbonate and aliphatic dihydric alcohol as raw materials, and carrying out transesterification and polycondensation reaction to obtain the isosorbide polycarbonate. The keto acid metal salt is used as the catalyst for synthesizing the isosorbide polycarbonate, the catalyst is low in price and not prone to inactivation, and the isosorbide polycarbonate with high molecular weight and ideal transparency is catalytically synthesized.

This invention pertains to composite material manufacturing technology and relates to a method and structure for curing and stamping at the chamfered position of a honeycomb sandwich structure autoclave. A thermally conductive material is laid on the plane where the stamping position of the honeycomb sandwich structure is located, extending from the stamping position to the center of the plane; the thermally conductive material is positioned between the release film, the breathable felt, and the vacuum bag.

The utility model discloses a device for simulating and measuring vertical load stress, which comprises an upper bearing plate, a load distribution plate is arranged below the upper bearing plate, pressure guide covers are fixedly mounted at four corners of the bottom end of the upper bearing plate, annular claw buckles are fixedly mounted at four corners of the top end of the load distribution plate respectively, and a pressure measuring column is inserted into each annular claw buckle. The pressure measuring column is sleeved with a protective cylinder, the pressure measuring column is sleeved with a first spring, the first spring is arranged above the protective cylinder, and the upper bearing plate, the load distribution plate and other structures are used in cooperation, so that the device can well simulate the vertical load generated by the beam body under the driving load and the perturbation caused by the self weight of the beam body; therefore, the device can well obtain data of longitudinal compression force and transverse shear force, normal proceeding of follow-up construction work is ensured, and meanwhile the device is simple in structure, quite convenient to carry and install, low in cost and high in created economic benefit.

The invention discloses a gecko-like magnetic control reversible attachment / desorption device, which comprises a substrate layer made of a magnetic composite material, bionic cilia and adsorption discs, a plurality of bionic cilia are arranged on the surface of the substrate layer, one end of each bionic cilia is connected with the surface of the substrate layer to form an inclined included angle, and the other end of each bionic cilia is connected with one adsorption disc. The device not only has the bionic characteristic of a gecko, but also has the capability of being controlled by using an external magnetic field, is flexible and diverse in driving mode, has good deformation performance, can bear larger deformation and tension without being damaged, and has the characteristics of small size, easiness in control and production, quick response and the like. The invention further discloses a preparation method of the adsorption disc, the adsorption disc can be automatically formed based on a magnetic surrounding aggregation mechanism, the adsorption disc has the advantages of being low in cost and easy to obtain, the preparation process is simple and efficient, and batch production can be achieved.

This invention discloses a two-stage regulation method to improve ergothioneine production efficiency. Seed culture of *Pleurotus ostreatus* is inoculated onto a fermentation medium supplemented with H2O2 and fermented for 5-7 days. Then, H2O2 is added again to the fermentation medium for 0.5-1.5 hours to stimulate fermentation, followed by the addition of vitamin C. Fermentation is terminated after 1.5-2.5 hours, and the mycelium is collected for ergothioneine extraction. The ergothioneine production efficiency was increased by up to 58.81% compared to the original strain. This invention's production method is simple and easy to control, yields high ergothioneine production, and all ergothioneine is intracellular, making it easy to harvest and simplifying subsequent purification processes, making it suitable for industrial production.

This invention belongs to the field of biomedical technology, specifically disclosing the application of mancozeb in the preparation of ERK inhibitors. Through zebrafish embryo models and HEK293T cell experiments, this invention demonstrates that mancozeb can specifically inhibit the MAPK / ERK pathway as an ERK inhibitor, and that at concentrations of 2μM to 8μM, it can induce a three-dimensional spiral notochord malformation in zebrafish embryos similar to that caused by 100μM U0126 treatment, providing a new approach for the preparation of MAPK / ERK pathway inhibitors.

This invention discloses a high-capsaicin-tolerant Bacillus subtilis strain and its construction method. The construction method is as follows: using CRISPR / Cas9 technology, the lmrA gene of Bacillus subtilis strain CGF-P-02 is replaced with a P43 promoter to obtain the high-capsaicin-tolerant Bacillus subtilis strain BS02; a second P43 promoter is used to replace the ytrA gene of Bacillus subtilis strain BS02 to obtain the high-capsaicin-tolerant Bacillus subtilis strain BS03. The high-capsaicin-tolerant Bacillus subtilis strain constructed in this invention exhibits high capsaicin yield during fermentation, can tolerate 84 mg / L capsaicin, and shows good stability and reproducibility. The acquisition method is simple and easy to operate.