33006results about How to "Increase resistance" patented technology

An oligonucleotide analogue useful for the antisense method, etc., having excellent enzyme resistance, having potent selective binding affinity for single-stranded RNA, and further having an excellent triplex-forming capacity with double-stranded DNA, and a nucleoside analogue useful for its production are provided.Nucleoside analogues, which are compounds of the general formula (I) and salts thereof, and oligonucleotide analogues containing one or more of the nucleoside analogues:where Base is an aromatic heterocyclic group or the like optionally having a substituent; R1, R2 and R3 are each a hydrogen atom, a protective group for an amino group, a protective group for a hydroxyl group, a phosphate group, or —P(R4)R5 [where R4 and R5 are each a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, etc.]; m=0 to 2; and n=1 to 3].

A shock absorbing component having a pair of surfaces with a plurality of inwardly extending indentations in the top and bottom surfaces. The indentations extend between the surfaces to provide support members for the shock absorbing component. At least some of the indentations are hemispherical. The surfaces may be formed of mesh material to allow the passage of gas or fluid therethrough. One or more inserts may be placed in the indentations. The shock absorbing component can be constructed by molding upper and lower shock absorbing component halves wherein the molds are configured to provide indentations in the top and bottom surfaces. The upper and lower halves are then joined to complete the shock absorbing component.

A coating composition is disclosed which comprises an aqueous polymeric matrix, a hydrophilic polymer, a colloidal metal oxide and a crosslinker. The coating composition when applied on medical devices is hydrophilic, shows improved lubricity, abrasion resistance and substrate adhesion on metallic or plastic substrates. The coating also shows improved water sheeting thus providing the coated substrates with anti-fog properties. The coating absorbs aqueous dye or stain solutions making the substrate suitable for printing.