1910results about How to "High purity" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention discloses a method and a system for efficiently removing a diaphragm of a non-liquid-injected roll core and accurately separating a positive pole piece and a negative pole piece. The method comprises the following steps: S1, carrying out primary slice dissociation; s2, primary winnowing and coarse removal; s3, secondary slicing and refined hydrolysis; s4, secondary winnowing and fine removal; s5, size grading; and S6, adaptive color selection. According to the method, traditional shredding is replaced by grading slicing, structural lamination of the materials in the treatment process is fundamentally avoided, the high removal rate of the diaphragms and high-precision sorting of pole piece materials in different forms are sequentially achieved, and the purity and process efficiency of overall recycled products are remarkably improved.

The invention discloses high-purity oxamide with concentrated particle size and spherical morphology, a preparation method of the high-purity oxamide and application of the high-purity oxamide in preparation of a slow-release fertilizer, and belongs to the technical field of oxamide synthesis and application. The method comprises the following steps: mixing an ammonia-alcohol solution and an alcohol ester solution, conveying the mixed solution into a series tubular reactor for reaction, and then conveying the mixed solution into a parallel tubular reactor for reaction after pressure stabilization and flow equalization to obtain a reaction solution containing oxamide; performing flash evaporation on the reaction liquid to obtain flash evaporation liquid and flash evaporation gas, and performing solid-liquid separation on the flash evaporation liquid to obtain solid oxamide and filtrate; and drying the solid oxamide to obtain the oxamide. The method realizes high conversion rate and high purity, and the product has ultrafine particle size distribution. The purity of the prepared oxamide is greater than or equal to 99%, the D50 particle size is concentrated to 50 + / -15 microns, the spherical morphology is uniform, the release is stable, and the oxamide has a very good effect in preparation of long-acting slow-release fertilizers and combustion inhibitors and research on the nitrogen utilization rate.

The invention discloses an ROS-responsive prostate cancer targeting prodrug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The prodrug is formed by covalently linking a prostate cancer targeting peptide SYEELR, a ROS (reactive oxygen species) response type ketal thiol (TK) connexon and an active molecule Devimistat. The preparation method comprises the following two steps: firstly, coupling Devimistat with a TK linker to obtain an intermediate Dev-TK, and then coupling the intermediate Dev-TK with an SYEELR peptide fragment to obtain a target product. The prodrug can specifically break and release Devimistat in a tumor high active oxygen microenvironment, and active targeting delivery is realized by virtue of the SYEELR peptide. The invention provides a novel prostatic cancer treatment strategy with accurate targeting, controllable release, enhanced curative effect and toxicity reduction potential.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The application discloses a double-hearth two-stage heating vacuum distillation furnace, which comprises an evaporation furnace and a condensation furnace which are communicated through a gas passage, wherein the evaporation furnace comprises an evaporation furnace body and at least one top heating mechanism which is detachably arranged on the top of the evaporation furnace body; and the condensation furnace comprises a condensation furnace body, a side heating structure and a furnace cover, wherein the condensation furnace body is divided into a temperature control condensation chamber and a plurality of layers of multistage condensation chambers, and the gas passage can be combined or replaced according to the required reaction conditions of different materials. The vacuum distillation furnace can collect different metals through the gradient change of the temperature of the two hearths, reduces the process of secondary distillation of volatile matters after the furnace is stopped, can complete the processing of diversified raw materials, improves the work efficiency and reduces the processing cost; the modular top heating mode directly radiates heat to the materials, improves the heat utilization rate, can realize the working mode of stopping the furnace without stopping the work, helps to improve the work efficiency, and is convenient for completing the furnace cleaning, maintenance and solid material taking and placing.

This application provides a method for preparing compound I-b or a pharmaceutically acceptable salt thereof, wherein (S)-N-methylamino-1-(2-thiophene)-1-propanol reacts with 4-fluorobenzo[1,3]dioxolane in a system containing sodium hydride and potassium benzoate to obtain compound I-b. This method has short steps, mild reaction conditions, and is simple to operate, making it suitable for industrial scale-up; moreover, the obtained product has high purity and low isomer content.

The invention belongs to the field of medical isotope separation and preparation, and particularly relates to a method for separating and purifying < 212 > Pb from a thorium solution, which comprises the following steps: 1) leacheate is introduced into a Pb selective adsorption column to pretreat the Pb selective adsorption column, and then < 232 > Th salt solution and leacheate are introduced in sequence; 2) continuously introducing a desorption solution into the Pb selective adsorption column, enabling the desorption solution passing through the Pb selective adsorption column to flow into the Th selective adsorption column, and collecting the outflowing desorption solution; a desorption solution only containing 212Pb is obtained; according to the method, the 212Pb in the high-concentration thorium solution can be separated and purified at the same time. While < 232 > Th impurity entrainment and pollution in a < 212 > Pb product are remarkably reduced, compared with a single-column process, the separation time is basically not increased. The separated 212Pb product has high radionuclide purity and chemical purity at the same time, and can meet related pharmaceutical requirements.

The invention discloses a preparation method of a fructus cannabis protein peptide product with effects of resisting fatigue and improving exercise ability, which comprises the following steps: performing preliminary crushing, ultralow-temperature freezing micro-crushing and low-temperature continuous phase-change extraction degreasing on fructus cannabis, performing step-by-step hydrolysis by using polysaccharase and 2.4 L bacterial protease to extract fructus cannabis protein, performing low-temperature salting-out, and performing freeze-drying to obtain the fructus cannabis protein peptide product with the effects of resisting fatigue and improving exercise ability. The fructus cannabis protein peptide powder is prepared through low-temperature ultrasonic dissolution promotion, high-pressure micro-jet homogenization, compound enzyme C hydrolysis, 1% pepsase, high-temperature enzyme deactivation, chlorophyll removal through counter-current extraction, hydrogen peroxide decoloration, ultralow-temperature instantaneous concentration, low-temperature vacuum belt type drying and low-temperature ultrahigh-pressure sterilization. The fructus cannabis protein peptide prepared by the invention has the following remarkable effects: 1, the exercise ability is remarkably improved, the accumulation of lactic acid and urea nitrogen is reduced, the exhaustion time is prolonged, and the physical and mental fatigue is relieved; 2, the content of hepatic glycogen and muscle glycogen is obviously increased, the energy reserve of the body is increased, the explosive power and the reactivity are improved, and the athletic performance is improved; and 3, the antioxidant level of the body is improved, and fatigue and immune recovery after exercise are promoted.

The invention belongs to the technical field of organic synthesis, and particularly relates to a catalyst-free continuous production method of chlorotert-butane, which comprises the following steps: adding diluted hydrochloric acid as a starting solution into the tower kettle of a reactive distillation tower, and heating the tower kettle to boil until reflux exists at the tower top; the method comprises the following steps: adding tert-butyl alcohol and concentrated hydrochloric acid into a mixing preheater for preheating, then continuously feeding from a feed port of a reactive distillation tower until the tower top temperature is 45-48 DEG C, the side discharge port temperature is 50-52 DEG C and the tower kettle temperature is 96-105 DEG C, and carrying out reflux according to a reflux ratio of (1.5-3): 1; and continuously extracting crude chlorinated tert-butane from a side discharge port of the tower, cooling, neutralizing, drying and filtering to obtain the chlorinated tert-butane. According to the invention, through the integrated design of the mixing preheater and the reactive distillation column, especially by utilizing the reactive distillation technology to continuously remove the product, the chemical equilibrium limitation of the traditional intermittent process is successfully broken, the raw material conversion rate is obviously improved, and meanwhile, the green production targets of flow simplification, energy consumption reduction and three-waste emission reduction are realized.

The invention discloses a double-frequency constant-temperature crystal oscillator and a manufacturing method thereof, and relates to the technical field of crystal oscillators, and the double-frequency constant-temperature crystal oscillator comprises a ceramic base and a ceramic bottom plate which are integrally formed by adopting an LTCC (Low Temperature Co-Fired Ceramic) process; the high-frequency quartz crystal and the low-frequency quartz crystal are respectively arranged in independent closed cavities, and unified heating and accurate temperature control are realized through the high-heat-conduction diamond copper substrate, the metalized heat conduction holes and the partitioned temperature sensing chips; the two paths of signals are output through independent interconnection paths, and the crosstalk is lower than-50dBm. According to the invention, the dual-frequency high-stability low-noise output is realized under the similar volume, and the requirements of a flight control system on a high-integration-level and high-reliability frequency source are met.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-9, its encoded nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-9 and other substances in the preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, uterine fibroids, benign prostatic hyperplasia, etc.

This utility model relates to the field of hydraulic oil tank technology, specifically a hydraulic oil tank for a marine EHA power unit, comprising a tank body, an inlet, and a return outlet. The inlet is located at the top of the tank body, and a vent is located on one side of the inlet. A return outlet is located on one side of the top of the tank body. A filter screen limiting groove is provided in the return outlet, and a metal filter screen is installed in the filter screen limiting groove by screws. A sealing cap is installed at one end of the return outlet by clamping bolts. A return pipe is connected to one side of the sealing cap, and a sealing valve B is provided on the return pipe. An oil pump is installed on one side of the bottom of the tank body via a mounting base. The hydraulic oil tank for a marine EHA power unit facilitates the filtering of solid particles in the hydraulic oil, improves purity, facilitates recycling, and makes it easy to clean or replace the metal filter screen.

The application relates to the field of chemical material preparation, and particularly discloses a high-purity silicon nitride powder and a preparation method thereof. The preparation method of the high-purity silicon nitride powder is as follows: 30-40 parts of silicon dioxide nano particles are mixed with 12-40 parts of carbon black to obtain a blend by adding deionized water, the blend is stirred, and the blend is dried at 60-65 DEG C to obtain a silicon-carbon precursor; nitrogen is introduced into the carbon-silicon precursor, the temperature is increased to 1350-1500 DEG C, and the temperature is kept constant to obtain a crude product; ammonia is continuously introduced into the crude product, the temperature is kept constant at 1300-1400 DEG C to obtain a first purification product; the first purification product is cooled to 600-650 DEG C, oxygen is introduced, and the temperature is kept constant to obtain a second purification product; and the second purification product is cooled to obtain the product. The preparation method of the high-purity silicon nitride powder can prepare high-purity silicon nitride powder with a purity of 99.65% or above.

The invention belongs to the technical field of sewage treatment, and discloses a DO-ORP coordinated regulation artificial tidal food web sludge in-situ reduction and phosphorus recovery method. Aiming at the problems of high energy consumption, serious phosphorus resource loss and the like of traditional sludge treatment, a multi-stage food chain consisting of microorganisms, protozoa and metazoan is implanted by constructing an artificial tidal environment with periodic alternation of wetting and drying; according to the method, the metabolic activity of sludge hydrolysis flora and phosphorus-accumulating bacteria is activated by utilizing cooperative regulation and control of DO concentration and ORP, microbial extracellular polymeric substances are triggered to be depolymerized by adopting tidal periodic oscillation, in-situ reduction of sludge biomass is realized by combining a food web cascade predation effect, and phosphorus is synchronously removed by virtue of an anaerobic phosphorus release-aerobic phosphorus uptake coupled struvite crystallization process. The method is suitable for treating the excess sludge of a municipal sewage treatment plant, and the high-purity magnesium ammonium phosphate fertilizer is produced while the dehydration energy consumption is reduced by 40%.

This invention discloses a resource-based treatment system and method for barium sulfide slag. The system involves crushing and leaching the barium sulfide slag using a pretreatment unit, thereby leaching out the barium sulfide. The barium-enriched washing solution is then processed through an electrophoretic deep treatment unit to achieve high-value recovery of sulfur and barium elements, ultimately realizing the resource utilization of the barium slag. The entire process is pollution-free and has the advantages of being environmentally friendly, having high added value, high sulfur utilization efficiency, low cost, and simple operation. It is suitable for large-scale industrial applications and has broad market prospects and significant economic benefits.

This invention discloses a method for preparing high-purity oxygen-free copper, relating to the field of metallurgical technology. The method includes multi-stage electrolytic refining, gradient-heating vacuum melting, inert gas-protected refining, electron beam melting, hydrogen plasma arc melting, directional solidification, and post-treatment steps. The multi-stage electrolytic refining utilizes a specific component electrolyte and periodically commutated current; vacuum melting is combined with bidirectional electromagnetic stirring; inert gas-protected refining is combined with a gradient reduction composite covering agent; electron beam and hydrogen plasma arc melting achieve deep purification and deoxidation; and directional solidification and two-stage annealing ensure product performance. The high-purity oxygen-free copper prepared by this invention has a conductivity of 102.3% IACS, a copper content ≥99.9999%, and an oxygen content <1.0 ppm. It exhibits high purity, low oxygen content, and excellent conductivity. The process is stable and controllable, making it suitable for high-end electronics applications.

This invention provides a resource recovery device system for lithium precipitation mother liquor. Through the coordinated use of a pretreatment unit, conditioning unit, extraction unit, washing unit, back-extraction unit, and raffinate post-treatment unit connected in sequence, it achieves maximum recovery and utilization of lithium ions in the lithium precipitation mother liquor, reduces lithium resource waste, ensures the greenness, stability, and controllability of the extraction process, and results in a high-lithium liquid product with low metal impurity ion content and high lithium extraction rate, while the raffinate meets discharge standards. The resource recovery device system has a simple structure, low operation difficulty, and low manufacturing cost.

The invention relates to the field of biological catalysis, and discloses a method and a device for generating ursodesoxycholic acid through continuous flow catalysis of chenodeoxycholic acid. Comprising the following steps: (1) in the presence of first immobilized cells, carrying out a first catalytic reaction on a reaction system containing chenodeoxycholic acid to obtain a first product, the first immobilized cells expressing 7 alpha-hydroxysteroid dehydrogenase and lactic dehydrogenase; the concentration of the chenodeoxycholic acid in the reaction system is 40 to 70 mM; (2) adjusting the pH value of the first product to 8-9, and then in the presence of a second immobilized cell, carrying out a second catalytic reaction on the first product after the pH value is adjusted to obtain ursodesoxycholic acid, and the second immobilized cell expresses 7 beta-hydroxysteroid dehydrogenase and glucose dehydrogenase. According to the method, the stable activity of a catalytic system is kept, efficient conversion of high-concentration CDCA is achieved, meanwhile, precipitation of 7-KLCA is thoroughly avoided, and the synthesis efficiency, the product purity and the process continuity of UDCA are remarkably improved.

The application discloses a preparation method of an abacavir impurity, specifically, 2-azabicyclo[2,2,1]hept-5-en-3-one is used as raw material, and the abacavir impurity is prepared through ring opening, separation, separation, protection, reduction, deprotection, condensation, ring closure and condensation, and the application further discloses the use of the abacavir impurity prepared by the preparation method in detection and / or control of abacavir quality, and the application provides a new idea for synthesis of the abacavir impurity, the starting raw material of the synthesis method is easy to obtain, the synthesis route has mild reaction conditions, the reaction operation is safe, and the yield and purity are good, so that the preparation demand of the impurity can be met, and the application has important significance for research on the abacavir impurity.

The application discloses a preparation method of a silodosin key intermediate and belongs to the technical field of drug chemical synthesis. The silodosin key intermediate is prepared from indoline as raw material through halogenation, cyanation, N-benzoylpropylamine protection, substitution, amination, reduction and salt formation, and the silodosin key intermediate is compound 1. The synthesis line is novel, the raw reagents are easy to obtain or prepare, high-risk and high-pollution reagents are not used, the method is safe, environment-friendly, mild in reaction condition, easy and controllable to operate, the prepared silodosin key intermediate is good in purity, high in yield and high in atom utilization rate, and the industrial production problem of silodosin can be practically solved.

The present application relates to the technical field of shale gas sampling, in particular to a shale gas exploitation sampling device and method, the device comprises a box body and an inspection door, a filter box is arranged in the upper middle part of the box body, a low-temperature box is arranged in the lower middle part of the box body, an adsorption box is arranged in one end of the box body, a shunt pipe is arranged on the inner wall of the bottom end of the low-temperature box, a cooling mechanism for low-temperature water removal is arranged in the low-temperature box, a filtering mechanism for automatic filtering and automatic cleaning is arranged in the filter box, an adsorption mechanism for adsorption is arranged in the adsorption box, and a connecting mechanism for connecting a sampling pipeline is arranged in one end of the box body. The device can be suitable for sampling pipelines of different sizes and shapes, can ensure the firmness and sealing property of the connection, can automatically sample and purify different shale gases comprehensively, and can ensure the accuracy and sufficient amount of sampling.

The invention relates to the technical field of plant essential oil extraction, and discloses a valerian-rich rhizoma nardostachyos essential oil directional preparation process, which comprises: taking a functionalized compound solvent, adding rhizoma nardostachyos coarse powder according to a liquid-solid ratio, stirring and soaking to obtain a solid-liquid mixture; the solvent component comprises process water, sodium xylene sulfonate, dipotassium phosphate and polyethylene glycol 400; introducing steam into the mixture, heating to maintain slight boiling, carrying out first-stage distillation, and removing distilled low-boiling-point components to obtain resident in the kettle; cooling the resident to a constant temperature, adding sodium chloride, and stirring until the sodium chloride is dissolved to obtain a heterogeneous mixed system; the heating system is subjected to second-stage distillation, and distillate is collected; and carrying out oil-water separation on the distillate, and collecting an oil phase to obtain a finished product of the rhizoma nardostachyos essential oil. According to the method disclosed by the invention, a hydrotropy-salting-out phase change mechanism is matched with fractional distillation, so that high-efficiency desorption and directional enrichment of valerianone which is difficult to volatilize are realized while acidic and light component impurities are removed.

The application discloses a method for synthesizing tervalent tetraaryl iron porphyrin from pyrrole, aromatic aldehyde and ferrous salt, which comprises the following steps: adding anhydrous aluminum chloride, aromatic aldehyde, pyrrole and ferrous salt into DMF under stirring, and then heating and refluxing the reaction mixture for 0.5 hours under nitrogen; removing the nitrogen and continuing to heat the reaction mixture for a certain time; stopping the reaction; cooling the reaction mixture; and placing the reaction mixture at 273K overnight; and finally filtering the reaction mixture to obtain the iron porphyrin.

This invention relates to the field of separation membrane technology, and more specifically, to a highly selective PVA separation membrane, its preparation method, and its applications. The PVA separation membrane provided by this invention, modified with α-cyclodextrin and / or α-cyclodextrin derivatives, significantly improves the selectivity of the PVA separation membrane. It can be used to separate mixtures of organic matter and water, such as alcohol-water systems, and is suitable for the separation and preparation of high-purity products. The preparation method employed in this invention is simple and easy to operate, and does not introduce new impurities, making it applicable to the industrial production of high-purity products.

The application provides an anti-chlorpromazine monoclonal antibody and application and product thereof, and relates to the technical field of biology.The anti-chlorpromazine monoclonal antibody provided by the application has a variable region, which comprises a complementarity determining region CDR1-VH with an amino acid sequence as shown in SEQ ID NO.1, a complementarity determining region CDR2-VH with an amino acid sequence as shown in SEQ ID NO.2, a complementarity determining region CDR3-VH with an amino acid sequence as shown in SEQ ID NO.3, a complementarity determining region CDR1-VL with an amino acid sequence as shown in SEQ ID NO.4, a complementarity determining region CDR2-VL with an amino acid sequence as shown in SEQ ID NO.5 and a complementarity determining region CDR3-VL with an amino acid sequence as shown in SEQ ID NO.6.The antibody has good specific binding capacity for chlorpromazine.

The present application relates to the technical field of carbon dioxide capture, and discloses a carbon dioxide capture method, which comprises the following steps: (1) contacting raw gas with a perfluorinated solvent under a pressure of 2-7 MPa to perform absorption, so as to obtain purified gas G i and absorption liquid X containing carbon dioxide and nitrogen i ; optionally, the absorption liquid X i is at least divided into A i and B i parts, wherein the A i part is returned to step (1) to be added into the raw gas; the absorption liquid X i or the B i part is subjected to desorption, so as to obtain regenerated perfluorinated solvent Z i and desorption gas J containing carbon dioxide and nitrogen i ; (2) judging the carbon dioxide concentration in the desorption gas J i , when the carbon dioxide concentration in the desorption gas J i is less than 90 wt%, the desorption gas J i is used as the raw gas, and the step (1) is repeated. The method in the present application uses the perfluorinated solvent as the carbon dioxide absorbent, and can reduce the energy consumption of regeneration by pressure reduction, and is suitable for industrial popularization.

The present application discloses a device and method for rapidly preparing carbon from straws and recycling and treating flue gas and smoke dust. The device includes a pyrolysis and carbonization chamber and a collection and separation chamber which are communicated with each other; the pyrolysis and carbonization chamber and the collection and separation chamber are communicated with each other through a flue gas inlet; the collection and separation chamber includes a separation area in which a sprayer I is further disposed; and flue gas enters the separation area through the flue gas inlet and is then discharged. The method includes: introducing straws that are ignited outside into a pyrolysis and carbonization chamber; introducing flue gas produced by the pyrolysis and carbonization chamber in running into a collection and separation chamber via a flue gas inlet, and at least separately treating the flue gas in a separation area in the collection and separation chamber; and introducing the flue gas into the separation area, and converting main component-biomass energy in the flue gas into straw vinegar using a sprayer I in the separation area. In the present application, the gaseous biomass energy is continuously recycled and converted, and the main component-biomass energy in the flue gas is converted into the straw vinegar for recycling, so that the utilization rate of biomass energy of straws of the original device is increased by 30-33% to 50%.

The utility model relates to the technical field of catalyst recovery, disclose a kind of solid-liquid separation filter devices for desulfurization catalyst regeneration and recovery, including filter tank, the upper portion of the filter tank is equipped with support plate, the inside central position of the support plate is connected with support rod and is penetrated rotation, the lower end of the support rod is fixed with horizontal plate, and the both ends of the horizontal plate are fixed with mesh box jointly;The utility model is filtered by telescopic cylinder and drives mesh box into filter tank, and utilizes motor drive carousel, rotating plate, slide bar, fixed rod and rack, drives gear and support rod, horizontal plate and mesh box reciprocating rotation;The reciprocating rotation of mesh box makes the desulfurization catalyst accumulated in it continue to turn over, effectively prevent the mesh hole blockage caused by the accumulation compaction of desulfurization catalyst in mesh box bottom, and also promote the impurities adhered to the surface of desulfurization catalyst particle to fall off in turning process and discharge with waste liquid, so as to improve the purity of desulfurization catalyst after separation.

The invention discloses a method for synthesizing a tonalid intermediate HMT, and belongs to the technical field of organic synthesis. According to the method, a specific liquid catalyst and an organic solvent are selected to prepare a catalyst phase, raw materials required for synthesis of tonalid are mixed according to a reasonable ratio to form a raw material phase, then the two phases are introduced into a microchannel reactor for a catalytic reaction, and after the reaction is completed, a target product is obtained through post-treatment steps such as quenching, water washing and rectification. Aiming at the defects that a solid catalyst in the prior art is difficult to realize homogeneous reaction and the reaction process is violent and difficult to control, by optimizing catalyst type selection and reaction process design, a reaction system has good homogeneous property, the reaction process is milder and is easy to accurately regulate and control, the stability and reliability of product preparation are effectively improved, and the method is suitable for industrial production. The method is suitable for industrial large-scale production.