2328 results about "Cyclodextrin" patented technology

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention provides a ziconotide nasal-brain delivery preparation which is high in brain targeting, safe and noninvasive and directly enters the brain through nasal administration. The nasal-brain delivery preparation comprises an active component ziconotide and an absorption enhancer, wherein the absorption enhancer is selected from one or more of dodecyl-beta-D-maltoside (DDM), menthol, hydroxypropyl-beta-cyclodextrin (HP-beta-CD), sodium glycocholate (SGC) and related derivatives thereof. The absorption enhancer with a specific type and content and the ziconotide cooperate and act together, so that the ziconotide bypasses a blood brain barrier, enters the brain through a nasal olfactory mucous membrane, forms a medicine storage bank in an olfactory bulb, is slowly released to the brain and keeps a long-term medicine effect, and therefore, a traditional ziconotide intrathecal administration mode is abandoned; the ziconotide nasal-brain administration mode is created, and the ziconotide nasal-brain administration method is a new-generation therapy for pain diseases related to the central nervous system.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention discloses a cellulose coated diaphragm and a preparation method thereof in the field of lithium ion batteries, the diaphragm comprises alpha-cellulose pulp, a cellulose grafted phenylboronic acid-co-oligomeric ethylene oxide copolymer, a thermal response star zwitterionic polymer and nano aluminum oxide, and an N-methylmorpholine-N-oxide aqueous solution is adopted as a solvent system. The preparation method comprises the following steps: firstly synthesizing a cellulose grafted copolymer with dynamic borate bonds through atom transfer radical polymerization, then preparing a star polymer with thermal response arms and zwitter-ion terminals by taking cyclodextrin as a core, and finally mixing all the components to prepare coating slurry. And the composite diaphragm is prepared through the processes of coating, phase conversion, ultraviolet curing and drying. The diaphragm combines the thermal stability and lyophilic property of cellulose, forms a dynamic self-adaptive interface layer through the synergistic effect of two functional compounds, has the advantages of active safety protection, dendritic crystal inhibition, long cycle life and the like, and remarkably improves the comprehensive performance of the lithium ion battery.

The invention provides a composite pollution repairing agent as well as a preparation method and application thereof, and belongs to the technical field of environmental functional materials. The composite pollution repairing agent comprises biochar, nano zero-valent iron (nZVI) loaded on the biochar, cyclodextrin and heteroatoms, and at least part of the nZVI is wrapped in the cyclodextrin. According to the prepared composite pollution repairing agent, solid waste resource utilization can be effectively achieved, the removal rate of micro-plastics reaches 90% or above, and the removal rate of heavy metal is 100%. The composite pollution repairing agent has excellent performance and good application prospect, provides a feasible solution for micro-plastic and heavy metal composite pollution treatment, and shows remarkable practical application value.

The invention discloses an electrolytic adhesive, an electrolytic cotton adhesive tape and a preparation method of the electrolytic adhesive. The electrolytic cotton adhesive tape comprises the following components in parts by weight: 5-10 parts of 1, 1 '-ferrocene diformyl chloride, 10-15 parts of acrylic acid beta-cyclodextrin ester, 3-8 parts of polyethylene glycol diglycidyl ether, 10-20 parts of ionic liquid, 1.5-3 parts of a cross-linking agent, 10-15 parts of tackifying resin and 0.5-1.5 parts of an initiator, and a polymer matrix comprises an acrylic acid-hydroxypropyl acrylate copolymer and acrylic acid-2-ethylhexyl ester. Comprising an adhesive layer and an adhesive tape base layer, the adhesive layer is prepared from the electrolytic adhesive, and the adhesive tape base layer is prepared from acrylic foam; the obtained electrolytic cotton adhesive tape has high initial adhesion and viscosity strength after power-on and power-off re-adhesion.

The invention discloses a reaction buffer solution for improving endotoxin detection sensitivity of a recombinant tachypleus amebocyte lysate, a kit containing the reaction buffer solution and application of the reaction buffer solution. The reaction buffer solution comprises the following components: a Tris-HCl buffer solution, magnesium ions, sodium chloride, cane sugar, ethylene glycol diethyl ether diamine tetraacetic acid, a nonionic surfactant and cyclodextrin or a derivative thereof. The invention also discloses a preparation method of the reaction buffer solution and a kit containing the reaction buffer solution. When the reaction buffer solution or the kit is used for detecting the endotoxin of the recombinant tachypleus amebocyte lysate, the sensitivity of the recombinant tachypleus amebocyte lysate for detecting the endotoxin can be improved by one order of magnitude, the lowest detection limit can reach 0.0005 EU / ml, the reaction buffer solution or the kit has strong anti-interference capability and short reaction time, and the detection efficiency is greatly improved.

The invention relates to the technical field of biomedicine, in particular to stem cell exosome-loaded bi-crosslinked hydrogel as well as preparation and application thereof, and the bi-crosslinked hydrogel comprises the following components in parts by weight: 50-90 parts of a matrix polymer; 0.1 to 5 parts of an active load; 1 to 10 parts of cyclodextrin; 5 to 20 parts of modified chitosan; 0.01 to 1 part of a photoinitiator; and 0.01 to 0.5 part of growth factors. Through double-network design of physical / chemical primary cross-linking and photo-initiation secondary cross-linking, the bottleneck that the mechanical property and the machinability of the traditional single cross-linking hydrogel are difficult to consider at the same time is overcome; meanwhile, the human umbilical vein endothelial cell exosome is introduced, and efficient loading, uniform dispersion and degradation coupling slow release of the exosome are realized by virtue of beta-cyclodextrin inclusion and a double-crosslinking network. Therefore, the problems of mechanics, degradation, cross-linking speed or tissue adhesion of cross-linked hydrogel in the prior art are solved.

Disclosed herein are dosage forms comprising a combination of: 1) an active pharmaceutical ingredient (API), 2) a cyclodextrin, and 3) a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the drug for the treatment of conditions such as pain.

The invention relates to the technical field of high polymer material synthesis, and particularly discloses methylpropanediol modified polyester and a preparation method thereof. The methyl propylene glycol modified polyester is prepared from the following raw materials in molar ratio through esterification-polycondensation: terephthalic acid and dihydric alcohol, the dihydric alcohol comprises ethylene glycol, diethylene glycol and methyl propylene glycol; the methylpropanediol is subjected to cyclodextrin inclusion treatment before being used; the molar ratio of the terephthalic acid to the ethylene glycol to the diethylene glycol to the methyl propylene glycol is 1: (0.7-0.9): (0.01-0.05): (0.2-0.6). The methyl propylene glycol modified polyester prepared in the invention has a low melting point and good mechanical properties.

The present disclosure relates to compositions comprising mixtures of hydroxypropyl-β-cyclodextrin, wherein the compositions may be isomerically purified. The disclosure also relates to methods of isomerically purifying a mixture of hydroxypropyl-β-cyclodextrins.

The invention provides a biochar repairing agent for marine sediments and a preparation method of the biochar repairing agent, and belongs to the technical field of repairing agents. The preparation method comprises the following steps: carbonizing straws, modifying by phosphoric acid and concentrated nitric acid, depositing ferroferric oxide-titanium dioxide, loading UiO-66-(COOH) 2 on the surface, coupling cyclodextrin-MOF and chitosan, crosslinking, performing magnet separation, washing and drying to obtain the biochar repairing agent for the marine sediments. The biochar repairing agent for the marine sediments prepared by the invention has a relatively large specific surface area and a plurality of coordination groups, can better fix heavy metal ions in the marine sediments, also has a photocatalytic degradation effect on organic pollutants, and is good in mechanical strength, easy to store and transport, safe, environment-friendly and easy to separate; wide application prospects are realized.

The invention discloses a preparation method of a double embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester, and relates to an inclusion compound based on modified cyclodextrin and a stable Pickering emulsion system thereof. According to the method, the uniformity of the cyclodextrin modification substitution degree is improved through ultrasonic assistance, the embedding rate and the embedding stability of hydrophobic active ingredients can be improved, meanwhile, the Pickering emulsion is stabilized, preparation of the double-embedded emulsion preparation is achieved, and the stability and the packaging efficiency of an emulsion preparation packaging delivery system can be effectively improved through the method. The method comprises the following steps: 1, preparing octenyl succinic acid cyclodextrin ester; 2, preparing an OSA-beta-CD / phenolic compound clathrate compound; and 3, preparing the dual-embedding emulsion preparation / emulsion. The invention provides a preparation method of a double-embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester. The double-embedding emulsion preparation / emulsion can be applied to a double-embedding food functional component delivery system.

A clathrate of 1-methylcyclopropene with α-cyclodextrin, obtained as a solid particulate product, is modified by comminuting, classifying, or both to obtain a modified particulate. When subjected to identical atmospheric disgorgement conditions of humidity and temperature, identical masses of the modified and unmodified particulates exhibit different rates of 1-methylcyclopropene disgorgement. Specifically, we have found that a smaller mean particle size is inversely related to a greater rate of 1-methylcyclopropene release.

The invention discloses a composite membrane with MXene directionally modified by alpha-cyclodextrin and a preparation method of the composite membrane, and belongs to the field of ion separation membrane materials, the composite membrane comprises MXene nanosheets and alpha-cyclodextrin; the MXene nanosheets are stacked layer by layer to form a sub-nano channel convenient for ions to pass through, and the alpha-cyclodextrin is connected to the end parts of the MXene nanosheets to form an interlayer channel inlet of the sub-nano channel; an interlayer channel inlet formed by alpha-cyclodextrin can select monovalent ions, the monovalent / divalent ion selectivity of the composite membrane exceeds 10 < 3 >, a sub-nano channel formed by MXene enables the monovalent ions to be transported smoothly, rapid transport of the monovalent ions is guaranteed, and the flux of the monovalent ions reaches 0.1 mol m <-2 > h <-1 >; therefore, the composite membrane provided by the invention can realize synchronous improvement of ion selectivity and ion flux; the structural stability of the composite membrane is improved, and the service life is prolonged.

The invention belongs to the technical field of cosmetics, and particularly relates to a water-in-oil-in-water three-phase coated microbead as well as a preparation method and application thereof. The water-in-oil-in-water three-phase coated microbead is of a spherical structure and sequentially comprises an outer water phase, an inner oil phase and an inner water phase from outside to inside, the outer water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components, the inner oil phase comprises caprylic / capric triglyceride, grape seed oil, olive squalane, tocopherol and other components, and the inner water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components. And the inner water phase comprises ampelopsis grossedentata extract, astragalus membranacus root extract and other components. According to the invention, an easily oxidized and unstable active matter is fully and firmly protected by adopting a droplet microfluidic coating technology, so that the active matter is free from external stimulation, active ingredients with different effects play multiple roles, and the composition has good anti-inflammatory, soothing and oil-controlling effects and can be applied to the field of cosmetics.

The invention discloses a preparation method of an artificial cell coated with a macrophage membrane, and belongs to the technical field of artificial cell preparation. The preparation method comprises the following steps: dissolving poly (diallyldimethylammonium chloride) and sulfobutyl-beta-cyclodextrin in ultrapure water, and mixing an aqueous solution of the poly (diallyldimethylammonium chloride) and an aqueous solution of the sulfobutyl-beta-cyclodextrin to obtain a PDDA / SBE-beta-CD condensation liquid droplet solution; and mixing the macrophage membrane suspension and the PDDA / SBE-beta-CD condensed fluid drops in an equal mass ratio, and realizing in-situ coating of the macrophage membrane by adopting an ultrasonic coating technology to obtain the artificial cell coated with the macrophage membrane. The PDDA / SBE-beta-CD condensation liquid droplet constructed by the invention has good stability under the conditions of physiological salt concentration and pH and at 37 DEG C; the artificial cell coated with the macrophage membrane is prepared by mixing with the macrophage membrane suspension, and the macrophage membrane serving as a shell not only can prevent aggregate aggregation, but also can improve the structural stability and biocompatibility.

The invention relates to natural dye and green chemical industry, and particularly discloses water-soluble biological indigo blue and a preparation method thereof. The water-soluble biological indigo comprises the following raw material components in parts by weight: 80-90 parts of a biological-based indigo concentrated solution; 0.5 to 1 part of dimethyl sulfoxide; 10 to 15 parts of a solubilizer A; 5-10 parts of a solubilizer B; and 10 to 15 parts of deionized water. According to the invention, the bio-based indigo concentrated solution synthesized by a biological method is used as a raw material, the water-soluble compound is innovatively formed through beta-cyclodextrin inclusion and povidone compounding, and the water-soluble compound has relatively high water solubility; the water solubility of the product is greater than or equal to 50g / L, the stability is excellent, the obtained indigo dye is natural in source, environment-friendly and high in water solubility, secondary pollution of the traditional dye to the environment is avoided, and the indigo dye is suitable for sustainable chemical industry and green dyeing and finishing industries and can be widely applied to the fields of textile dyeing, water-based ink, cosmetic color developing agents, medicines and the like.

The invention relates to the technical field of fertilizers, in particular to a seaweed-containing synergistic monoammonium phosphate fertilizer as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing a seaweed extract with beta-cyclodextrin, performing microencapsulation, and performing spray drying to obtain an embedded material; mixing with monoammonium phosphate and polyglutamic acid, and granulating; spraying salt-resistant compound bacteria liquid on the surfaces of the particles; and finally, coating the particles with a chitosan-sodium alginate composite film. According to the prepared synergistic monoammonium phosphate fertilizer finished product, the phosphorus utilization rate of monoammonium phosphate saline-alkali soil can be increased, the phosphorus fixation rate can be greatly reduced, the retention rate of active ingredients of the seaweed extract is greatly increased compared with that in the prior art, the rhizosphere survival rate of salt-tolerant flora is greatly increased, and the salt-tolerant flora, the seaweed extract and monoammonium phosphate cooperate to promote crop yield increase.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention relates to the technical field of fiber fabrics, and particularly discloses a moisture-absorbing and quick-drying polyester fiber, a fabric and a preparation process of the moisture-absorbing and quick-drying polyester fiber, the moisture-absorbing and quick-drying polyester fiber fabric is obtained by dipping a polyester fiber fabric in a finishing liquid, and the polyester fiber fabric is obtained by knitting mixed yarns; the blended yarn is composed of moisture-absorbing and quick-drying polyester fibers, cotton fibers and spandex fibers according to the mass ratio of 100: (25-42): (5-12), and the moisture-absorbing and quick-drying polyester fibers are obtained by melt blending and spinning of polyester chips and modified composite particles. The modified composite particles are obtained by blending alkenylated titanium dioxide coated silicon dioxide composite particles, maleic anhydride and butenedioic acid mono-esterification-beta-cyclodextrin, the prepared fabric has good hygroscopicity, sweat can be rapidly captured, rapid diffusion and evaporation are achieved through a moisture guiding channel in the fiber, collaborative optimization of moisture absorption, rapid drying and washing fastness is achieved, and the fabric has the good moisture absorption effect. Meanwhile, the fabric is good in comfort and durability and excellent in mechanical property.

The invention belongs to the field of animal feed additives, and particularly relates to a microcapsule preparation containing origanum vulgare essential oil as well as a preparation method and application of the microcapsule preparation. The preparation method of the microcapsule preparation containing origanum vulgare essential oil comprises the following steps: S1, dissolving modified beta-cyclodextrin and modified starch in water to obtain a wall material solution; s2, uniformly mixing oregano essential oil to prepare a core material solution, and dissolving an emulsifier in the core material solution to form an oil phase; s3, mixing the wall material solution with an oil phase, and homogenizing to obtain a solution A; and S4, adding a stabilizer into the solution A, uniformly mixing, and spray-drying to obtain the microcapsule preparation containing the origanum vulgare essential oil. The oregano essential oil entrapped microcapsule preparation is prepared by adopting the modified beta-cyclodextrin as a wall material and the modified montmorillonite as a stabilizer, so that the stability and the entrapment efficiency of the oregano essential oil are remarkably improved, the intestinal targeted release of the oregano essential oil is also realized, and the growth and development of animals are promoted.

The invention relates to the field of textile materials, and discloses a multi-thread elastic knitted fabric and a preparation method thereof.The multi-thread elastic knitted fabric is prepared from, by weight, 30 parts of ternary polymerization elastic fibers; 70 parts of modified bamboo fiber; the ternary copolymerized elastic fiber is prepared from the following raw material components in parts by weight: 28-32 parts of polylactic acid; 38 to 42 parts of polytrimethylene terephthalate; 28 to 32 parts of poly (butylene succinate); 1 to 3 parts of graphene nanosheets; 0.5 to 1.5 parts of epoxidized soybean oil; 2 to 4 parts of beta-cyclodextrin; the modified bamboo fibers are subjected to enzymatic treatment, silane coupling agent modification, dopamine coating treatment and ultrasonic treatment. Through micro gradient structure design and multi-step functionalization treatment of the ternary polymerization elastic fibers and the modified bamboo fibers, unification of excellent elastic recovery, comfort, multifunctionality and durability is achieved.

The invention relates to an antibacterial and deodorant particle which comprises an active particle and a hydrophilic film wrapping the outer surface of the active particle. The active particles comprise the following raw material components in parts by weight: 15-20 parts of SEBS, 8-15 parts of silicon dioxide, 10-20 parts of sepiolite powder, 6-16 parts of an antibacterial agent, 2-5 parts of sodium stearate, 2-5 parts of sodium citrate, 5-10 parts of beta-cyclodextrin, 18-27 parts of an adhesive and 1-3 parts of an odor neutralizer; the hydrophilic film is formed by forming a hydrophilic material. According to the antibacterial and deodorant particles, SEBS serves as a hydrophobic elastic framework of active particles, and free diffusion of active ingredients in the particles is limited through hydrophobic entanglement of molecular chains; meanwhile, a hydrophilic material is used as an outer coating film, and the release rate of the active components is controlled by adjusting the interface action of the active particles and sewage, so that the antibacterial and adsorption deodorization active components in the antibacterial and deodorization particles are stably and slowly released; it is ensured that the efficient and long-acting antibacterial and deodorizing effect can be achieved for 14 days in complex water environments such as domestic sewage treatment.

The invention relates to the field of material chemistry on-line detection, in particular to a 1, 2, 4-trichlorobenzene on-line detection material and a preparation method thereof, and provides a film-forming sensitive layer material capable of being coated on the surface of a transducer, and the film-forming sensitive layer material comprises chitosan, a crosslinking component with the content of 0.1-5wt% in terms of glutaraldehyde and magnetic core-shell molecularly imprinted particles after being dried, the magnetic core-shell molecularly imprinted particle contains a ferroferric oxide magnetic inner core, a silicon dioxide middle layer and a molecularly imprinted polymer shell layer, and the shell layer is a cyclodextrin methacrylate and ethylene glycol dimethacrylate copolymer network and takes 1, 2, 4-trichlorobenzene as a template. The material keeps the membrane integrity and long-term stability under the working conditions of circulation and regeneration and also gives consideration to quick response, and the residual 1, 2, 4-trichlorobenzene is controlled to be not greater than 0.10 wt% and the residual glutaraldehyde is controlled to be not greater than 0.5 wt%. The method is used for relieving structural mass transfer contradiction and processing and coating coupling contradiction caused by high filler load, and has online detection application value.