62results about How to "Solubility" patented technology

The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.

The present invention relates to an octreotide sustained release delivery system for treatment of diseases relating to somatotropin and/or somatostatin. The sustained release delivery system of the invention includes a flowable composition containing an octreotide compound, and an implant containing the octreotide compound. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and an octreotide compound.

A composition defined:

• • either as comprising at least one Broensted acid, designated HB, dissolved in a liquid medium with an ionic nature of general formula Q+A−, in which Q+ represents an organic cation and A− represents an anion that is different from B,
  • or as resulting from dissolving at least one Broensted acid, designated HB, in a non-aqueous liquid medium with an ionic nature of general formula Q+A−, in which Q+ represents an organic cation and A− represents an anion that is identical to the anion B, can be used as a catalyst and solvent in acid catalysis processes, in particular in the alkylation of aromatic hydrocarbons, the oligomerization of olefins, the dimerization of isobutene, the alkylation of olefins by isoparaffins, the isomerization of n-paraffins into isoparaffins, the isomerization of n-olefins into iso-olefins, the isomerization of the double bond of an olefin and the purification of an olefin mixture that contains branched alpha olefins as impurities.

A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.

A vehicle for topical application which contains a liquid eutectic mixture of hydrophobic compounds to improve solubility of pharmaceutically active component and enhance topical and transdermal delivery.

The invention relates to a powerful cleaning agent and belongs to the field of fine chemical automotive chemicals. The cleaning agent is prepared from surface active agents, alcohol additives, oiliness additives, auxiliary agents and water. The surface active agents and the oiliness additives play roles of solubilization, dissolving and washing, the alcohol additives jointly act with the two mentioned components for forming stable microemulsion and have certain permeation, moistening and dissolving functions, the three components jointly act so that the cleaning agent can achieve a good cleaning effect, and the auxiliary agents are functional additives. The cleaning agent has no side effect on cast iron, cast aluminum, leather, fabric, rubber, plastic and the like and can effectively clean an engine or the surface of the interior without generating phenomena of corrosion, color fading, bubbling, falling and the like.

The invention discloses a skin caring composition having a function of removing acne marks, a preparation and a preparation method of the skin caring composition. The skin caring composition consists of the following functional components in parts by weight: 0.01-2 parts of zinc carbonate hydroxide, 0.01-0.1 part of borax, 0.001-0.01 part of amber powder, 0.001-0.05 part of pearl powder, 0.05-0.5 part of allantoin, 1-5 parts of butyrospermum parkii, 0.1-0.5 part of angelica extract, 0.1-0.5 part of bighead atractylodes rhizome extract, 0.01-0.1 part of centella extract and 0.025-0.1 part of borneol. The skin caring composition is scientific and strict in formula, definite in effect and free from toxic and side effect, and is capable of effectively removing acne marks and other scar tissues; the skin caring composition has a function of removing acne marks, and is capable of obviously reducing skin roughness and content of skin melanin and the like; and the skin caring composition can guarantee a good skin status.

Various methodologies for the immobilization of molecules such, as multistranded nucleic acid molecules, are described. The methodologies include activation of solid supports, as well as treatment of, e.g. termini of nucleic acid molecules to render them more receptive to immobilization on surfaces.

An object of the present invention is to improve the water dispersibility of the PVA-based resin and also to suppress the swelling of the PVA-based resin.

The object is achieved by organic-inorganic composite particles, which have an average particle size of preferably 1 μm to 3,000 μm, including a polyvinyl alcohol-based resin and a component having a three-dimensional siloxane crosslinked structure that is derived from a hydrolysis-polycondensation product of an alkoxysilane and/or a low condensate thereof, wherein the alkoxysilane includes a T unit and/or a Q unit as a structural unit (s), and a Si content with respect to a total weight of the composite particles is 0.1 wt % or more and 23 wt % or less in terms of SiO₂.

The present invention is directed to a buprenorphine sustained release delivery system capable of delivering buprenorphine, a metabolite, or a prodrug thereof for a duration of about 14 days to about 3 months. The buprenorphine sustained release delivery system includes a flowable composition and a solid implant for the sustained release of buprenorphine, a metabolite, or a prodrug thereof. The implant is produced from the flowable composition. The buprenorphine sustained release delivery system provides in situ 1-month and 3-month release profiles characterized by an exceptionally high bioavailability and minimal risk of permanent tissue damage and typically no risk of muscle necrosis.

The present invention is directed to a sialylated isolated antibody specific for an antigen selected from autoimmune antigens, allergens, MHC molecules or Rhesus factor D antigen, comprising an Fc-portion of IgG type, and exhibiting a sialic acid residue at the Fc-portion for use in treatment and/or prophylaxis of autoimmune disease, allergy, transplant rejection or Rhesus factor D reactivity and to methods of producing such an antibody.

A production method of cellulose film wherein cellulose film is produced by preparing a polymer solution through dissolving cellulose ester in a solvent containing a prescribed organic solvent as the main component, forming a filmy object from the prepared polymer solution, and evaporating the solvent in the filmy object; the residual amount of the organic solvent is reduced while the film quality is not degraded, and the production efficiency is degraded to a least possible extent; a poor solvent, highest in boiling point among the materials contained in the solvent, is added in the content ranging from 0.1 wt % to 1.0 wt %, taking the total amount of the solvent in the prepared polymer solution to be 100 wt %; and the solubility of cellulose ester in the poor solvent is inferior to the solubility of the cellulose ester in the organic solvent which is the main component of the solvent.

The invention relates to a paint remover for removing a paint film on the surface of a tin-plated steel plate for a food can and a using method thereof, wherein the paint remover is prepared from the following raw materials in percentage by weight: 25-35% of dibasic acid ester, 20-35% of 1, 2-propylene glycol carbonate, 8-15% of absolute ethyl alcohol, 16-25% of lactic acid and 2.5-6% of cetyl trimethyl ammonium bromide. The paint remover is prepared by a method comprising the following steps: firstly, burdening the raw materials of the paint remover according to the content thereof; adding the raw materials according to the sequence from solid to liquid respectively, then stirring for 5-15 minutes at room temperature, and sealing and reserving after mixing uniformly. The using method of the prepared paint remover for removing the paint film on the surface of the tin-plated steel plate for the food can comprises the following step of: immersing objects for removing the paint completely in the paint remover, wherein the using temperature of the paint remover is 25-80 DEG C, the best using temperature is 60-80 DEG C, and the immersing time is 1-15 minutes. The paint remover for removing the paint film on the surface of the tin-plated steel plate for the food can and the using method thereof provided by the invention have the characteristics of good environment-friendly performance, stable solvent components, paint removing efficiency and tiny metal corrosion performance.

The invention discloses a calcium phosphate bioactive ceramic and a preparation method thereof, and relates to the field of biomaterials. The calcium phosphate bioactive ceramic is prepared from the following ingredients in parts by weight: 50-75 parts of tetracalcium phosphate, 3-9 parts of titanium oxide, 3-8 parts of aluminum silicate fiber, 2-5 parts of zinc oxide, 10-22 parts of tertiary calcium phosphate and 6-10 parts of calcium oxide. The preparation method comprises the following steps: (1) weighing; (2) ball milling; (3) cold press molding; (4) high-temperature calcining; (5) cooling. The calcium phosphate bioactive ceramic has certain mechanical stability and better biocompatibility; meanwhile, the calcium phosphate bioactive ceramic can slowly dissolve and release the bone nutrition elements of calcium and phosphorus, promotes bone growth, and is an ideal bone renovating biomaterial.

The invention relates to ginkgo leaf tea and a preparation method thereof. The method comprises the following steps of: (1) cutting ginkgo leaves into ginkgo leaf threads, extracting ginkgo leaves with alcohol, preparing an alcohol filtrate, and concentrating; (2) grinding chrysanthemum, fiveleaf gynostemma herb and green tea into coarse powder, mixing coarse powder, and sterilizing; and (3) fully stirring and uniformly mixing a concentrated solution obtained in the step (1) and mixed powder, drying, sieving, and drying coarse particles and powder to obtain ginkgo leaf tea. In the tea components, fiveleaf gynostemma herb contains a plurality of gypenosides, and has the effects of lowering TC (Total Cholesterol) and TG (Triglyceride); ginkgo leaf contains flavone, and has the effect of lowering TC; fiveleaf gynostemma herb and ginkgo leaf co-act with each other, so that blood fat is lowered; chrysanthemum can be used for increasing high-density lipoprotein, lowering serum cholesterase and triglyceride acid, playing a certain role in adjusting blood fat, and adjusting flavor appropriately simultaneously; tea-catechin in green tea is used for lowering serum cholesterase level by increasing the excretion of lipoid substances; and the four types of raw materials act in a synergistic way, so that a very good effect of lowering blood fat is achieved.

The present invention is directed to a buprenorphine sustained release delivery system capable of delivering buprenorphine, a metabolite, or a prodrug thereof for a duration of about 14 days to about 3 months. The buprenorphine sustained release delivery system includes a flowable composition and a solid implant for the sustained release of buprenorphine, a metabolite, or a prodrug thereof. The implant is produced from the flowable composition. The buprenorphine sustained release delivery system provides in situ 1-month and 3-month release profiles characterized by an exceptionally high bioavailability and minimal risk of permanent tissue damage and typically no risk of muscle necrosis.

Method for producing a plastic preform, the method comprising a first step of producing a plastic preform from raw material, and a second step of applying an outer layer to the plastic preform, wherein the outer layer forms a bond with the plastic preform, and is insoluble in aqueous solutions having a pH-value between 3 and 10, and well soluble in aqueous solutions having a pH-value in a range of less than 3 and/or more than 10.