1535 results about "Alkylation" patented technology

The present invention uses commercially available 3-aminopropylsilane coupling agent, diallylamino polyether acrylate, and an alkylating agent, or γ-propanesultone, or γ-butyrolactone as raw materials, and through an aza-Michael addition reaction and a quaternization reaction, a multifunctional silane coupling agent containing one or more quaternary ammonium cations, or sulfobetaine, or carboxybetaine in its molecular structure is prepared, which is used for the surface modification of bioactive glass, and the bioactivity, antibacterial and antifungal properties, and hydrophilicity enhancement effects after the surface modification of bioactive glass are obtained.

The invention discloses a modified amine curing agent and a preparation method thereof, and an epoxy resin composite material and a preparation method thereof, and belongs to the field of resin and composite materials. According to the curing agent, a C2-C8 alkyl chain is grafted to a methylene site of 4, 4 '-diaminodiphenylmethane (MDA) through free radical substitution and alkylation reaction, and a molecular structure with a flexible alkyl chain and a rigid benzene ring is formed. The preparation method comprises the following two steps: generating a halogenated intermediate from MDA and a halogen simple substance under certain reaction conditions, alkylating the halogenated intermediate with a Grignard reagent (RMgX), and purifying. The curing agent and epoxy resin are compounded, heated and cured, so that the epoxy resin composite material has relatively high impact strength and fracture toughness, has good tensile strength and hardness, has double functions of reinforcing and toughening, and solves the problem that reinforcing and toughening of traditional epoxy resin are difficult to be compatible; the method is suitable for the fields of aerospace, composite material adhesives and the like with harsh requirements on mechanical properties.

The invention discloses a magnetic ion exchange resin and a preparation method thereof, and the preparation method comprises the following steps: preparing a reaction solution which comprises magnetic particles, glycidyl methacrylate, divinylbenzene and a photoinitiator; the mass ratio of the glycidyl methacrylate to the divinyl benzene is (4.5-10): 1; an ultraviolet-initiated polymerization step: irradiating the reaction solution by ultraviolet light to initiate a polymerization reaction to obtain magnetic microspheres; a functional modification step: mixing the magnetic microspheres with an ammoniation reagent for ammoniation reaction to prepare ammoniated magnetic microspheres; and mixing the ammoniated magnetic microspheres with an alkylation reagent, and carrying out an alkylation reaction to prepare the magnetic ion exchange resin. According to the method, the production time is remarkably shortened, the extra energy consumption is reduced, and the process production flow is effectively simplified.

The invention relates to the technical field of antibacterial high polymer materials, in particular to an antibacterial nylon material as well as a preparation method and application thereof. The method comprises the following steps: carrying out anion ring-opening copolymerization on a seven-membered ring lysine monomer obtained by ring formation of lysine and a lactam monomer to obtain copolyamide, dissolving the copolyamide, and carrying out complete quaternization reaction by using halogenated hydrocarbon to obtain the antibacterial nylon material. The preparation method provided by the invention effectively avoids the problems of insufficient antibacterial property, obvious mechanical property reduction, poor thermal stability and the like of an antibacterial nylon material prepared by hydrochloric acid protonation in the prior art. Meanwhile, the seven-membered cyclic lysine monomer can be copolymerized without alkylation, the synthesis process is greatly simplified, the production efficiency is high, and the production cost is low. The prepared antibacterial nylon material has the characteristics of lasting and efficient antibacterial performance, high safety, environment friendliness, excellent mechanical property and thermal stability and the like, and can be widely applied to the fields of textiles, daily necessities, packaging materials, panels and the like.

This method for producing an aryl-alkylated indene composition involves: adding an arylalkyl group having a polymerizable unsaturated bond-containing group to an indene compound; and adding an arylalkyl group having no polymerizable unsaturated bond-containing group to the indene compound to which the arylalkyl group having a polymerizable unsaturated bond-containing group is added.

The present invention provides a multifunctional silane coupling agent, which is prepared from commercially available 3-aminopropylsilane coupling agent, acryloxy polyetheramine, and one of an alkylating agent, polyether sulfonate, γ-propane sultone or γ-butyrolactone through Michael addition reaction and quaternization reaction. The multifunctional silane coupling agent is a new variety carrying zwitterions, quaternary ammonium cations and polyether chains, enriching the functions and application scope of silane coupling agents. It can endow some modified materials with surface hydrophilicity, conductivity, antibacterial, antifogging, antifouling, biocompatibility, anticoagulant and wet lubrication properties, etc. at the same time.

The invention discloses a method for efficiently preparing an ionic super-crosslinked polymer by a mechanochemical method as well as a product and application of the ionic super-crosslinked polymer, and belongs to the technical field of polymer material preparation. The preparation method comprises the following steps: adding a nitrogen-containing monomer, a cross-linking agent and a catalyst into a good solvent to obtain a reaction solution; carrying out planetary ball milling treatment on the reaction liquid, and carrying out a Friedel-Crafts alkylation reaction; and after the reaction is completed, recovering and purifying the product to obtain the ionic super-crosslinked polymer. The ionic super-crosslinked polymer prepared by the preparation method disclosed by the invention has a highly crosslinked and abundant pore structure, and meanwhile, the ionic super-crosslinked polymer has the performance advantages of good adsorption performance, excellent chemical stability and high thermal stability. The synthetic method of the ionic super-crosslinked polymer provided by the invention is efficient, energy-saving and environment-friendly, the product quality is high, and the method has wide popularization and application prospects.

The invention belongs to the technical field of nuclear medicine molecular diagnosis and treatment, and discloses a modified CAIX targeting cyclic peptide, a nuclide marker and application of the modified CAIX targeting cyclic peptide in tumor diagnosis and treatment. According to the CAIX targeted cyclic peptide, a rigid bifunctional chelating agent RESCA is introduced to replace a traditional chelating agent, and a sulfonated or alkylated amino acid connector is combined, so that the enzymolysis resistance and in-vivo stability of the probe are remarkably improved. By optimizing the structure of the connector, the lipophilicity is reduced, liver and gall metabolism and non-specific uptake are reduced, and the high uptake rate of tumor target tissues is maintained. The therapeutic nuclide marker of the cyclopeptide can be used for intratumoral irradiation therapy using DOTA or NOTA in combination with an alkylated amino acid linker or an albumin ligand. Experiments show that the marker has high radiochemical purity, excellent pharmacokinetic characteristics and low kidney retention, and is suitable for precise diagnosis and targeted therapy of CAIX high expression tumors such as kidney cancer, colorectal cancer and brain glioma.

The invention provides a chemically modified tetanus toxin C fragment as well as preparation and application thereof. The method for chemically modifying the tetanus toxin C fragment comprises the following steps: 1) reacting the tetanus toxin C fragment with a reducing agent to reduce a disulfide bond in the tetanus toxin C fragment; and 2) carrying out a reaction on the reduced tetanus toxin C fragment and an alkylation reagent, and carrying out modification. The recombinant tetanus toxin C fragment prepared by the method disclosed by the invention not only meets the quality standard required by pharmacopeia, but also has the advantages of stable conformation, high yield, easiness in amplification and low cost, and has a wide application prospect in the preparation of human vaccines, veterinary vaccines and antibody drugs and the development process of in-vitro diagnostic reagents.

The invention discloses a synthesis process of vitamin C ethyl ether, and belongs to the technical field of vitamin C derivative synthesis. The process comprises the following steps: taking L-ascorbic acid as a raw material, adding acetone, anhydrous cupric sulfate and acetyl chloride, and reacting for 1-2 hours at 38-40 DEG C under the protection of nitrogen to obtain a vitamin C protector; adding alkali, water, an alkylating reagent and absolute ethyl alcohol into the reaction product, reacting for 3 hours at 75-78 DEG C under the protection of nitrogen, and performing reduced pressure distillation to obtain a vitamin C protector etherate; and finally, hydrolyzing by using cationic resin, removing a protecting group, and recrystallizing by using ethyl acetate to obtain the vitamin C ethyl ether. Through the synergistic catalysis of anhydrous cupric sulfate and acetyl chloride, the reaction time is remarkably shortened, and the product purity and yield are improved. Through detection, the product purity is more than 99.5%, the total yield can reach more than 80%, and an efficient and economical method is provided for industrial production of vitamin C ethyl ether.

This resist composition contains: a resin component (A1), the solubility of which in a developer solution changes due to the action of an acid; and a compound (D0) represented by general formula (d0-1). In the formula, Ar is an aromatic ring; OH is a hydroxy group; Xd01 is an iodine atom, a fluorine atom, a bromine atom, or a fluorinated alkyl group; Ld is a single bond or a divalent linking group; Z+ is S+ or I+; and Xd02 is an iodine atom, a fluorine atom, a bromine atom, or a fluorinated alkyl group. [Chemical formula 1]

The invention provides an efficient preparation method of hydrophobic chitosan. Chitosan can be directly alkylated to realize efficient synthesis of the hydrophobic chitosan only through one-step reaction. Compared with an existing indirect synthesis mode, the method has the advantages that firstly, extra consumption generated by any intermediate step is not needed, namely, the hydrophobic chitosan is efficiently synthesized by a one-pot one-step method; secondly, not only is amino in the chitosan directly alkylated, but also hydroxyl which cannot be indirectly alkylated can be alkylated to generate hydrophobic chitosan with both N-alkylated and O-alkylated, and the hydrophobic chitosan obtained by the method has more efficient hemostatic performance. Therefore, the method for producing hydrophobic chitosan through direct alkylation is more efficient, higher in yield, low in cost and more excellent in performance.

The invention relates to the field of feeding, and discloses a feeding system and a feeding method for intermediate synthesis, and the feeding method comprises the following steps: based on monitoring and analyzing the distribution condition of a catalyst bed layer in an alkylation process, establishing an inactivation model in combination with pressure fluctuation to dynamically compensate the activity of a catalyst, and adjusting the dispersity and the feeding speed of the catalyst through the inactivation model; based on the end of alkylation, obtaining the oxidant concentration in the oxidation process, establishing a target function with the reaction time based on the oxidant change rate, calculating the reaction time deviation degree through the target function, and intelligently adjusting the oxidant supply frequency in combination with analysis; feeding parameters of a plurality of historical reaction periods are obtained, deep collaborative optimization is carried out on the reaction time and the feeding parameters by establishing a three-layer intelligent regulation and control model, and a time scale correlation inactivation model and a time scale coupling free radical prediction model are constructed to solve the optimal adjustment amount; and carrying out real-time self-adaptive regulation and control on feeding parameters, and integrating prediction maintenance to carry out feedback iteration.

The invention discloses immobilized lipase based on bifunctional silicon dioxide as well as a preparation method and application of the immobilized lipase. Hydrophobic modification and covalent modification are performed on the surface of mesoporous silicon dioxide to obtain a bifunctional silicon dioxide carrier; the hydrophobic modification is any one of methylation modification, octylation modification, octadecyl alkylation modification, esterification modification and bromopropylation modification. The dual-functionalized silicon dioxide carrier is used for immobilization of lipase, and the prepared immobilized lipase can be used for production of biodiesel. The immobilized lipase provided by the invention is mild in enzyme reaction condition, good in biocompatibility, relatively high in enzyme activity, and excellent in stability and repeatability. In addition, by changing the ratio of the covalent modifier to the hydrophobic modifier, the catalytic activity and stability of the immobilized enzyme and the biodiesel yield are remarkably improved.

The invention relates to a low-temperature amino cross-linked modified self-polymerized microporous polymer gas separation membrane, a preparation method and application, and belongs to the technical field of gas separation membranes, and the preparation method comprises the following steps: 1) synthesizing a cross-linked precursor polymer PIM-BM through a bromomethylation reaction; (2) preparing a membrane casting solution from the PIM-BM and a micromolecular amine cross-linking agent, casting, and volatilizing to form a membrane; and 3) carrying out heat treatment at 40-80 DEG C under a vacuum condition for 6-32 hours to form a cross-linked network structure, wherein the thickness of the film is 40-120 microns. According to the invention, a covalent cross-linked network is constructed through a low-temperature Hofmann alkylation reaction of an amine cross-linking agent so as to limit the movement of a polymer chain segment; the strong CO2 affinity of amido (-NH2) realizes dissolution selectivity compensation, and the diffusion selectivity synergistic effect of an inherent micropore channel of PIM-BM is combined, so that the tradeoff limitation of permeability-selectivity of a traditional gas separation membrane is broken through; the cross-linked structure can effectively improve the physical aging resistance of the PIM-BM film, and has good long-term continuous operation stability; the preparation process is low in low-temperature process energy consumption, easy to scale, suitable for the fields of coal-fired flue gas CO2 capture, natural gas purification and the like, and has industrial application potential.

The invention discloses a synthesis method of oxyalkyl isourea and application of the oxyalkyl isourea as a free radical alkylation reagent. According to the synthesis method, cheap and rich alcohol compounds and carbodiimide are used as raw materials, oxygen alkyl isourea is synthesized in one step under the mild condition of metal catalysis, the synthesis process is simple and convenient, the yield is high, and hectogram-level large-scale preparation can be achieved. The synthesized oxyalkyl isourea can be used as a free radical alkylation reagent to be applied to a coupling reaction of metal catalysis, so that different alkylate products rich in saturated carbon sequence structures are prepared, and the method has a good application prospect.

The invention discloses a preparation method of ulinastatin adsorption resin, and belongs to the technical field of adsorption resin. Comprising the following steps: (1) preparing a water phase: adding pure water, gelatin, cellulose, sodium chloride and lignin into a reaction kettle until the materials are fully dissolved; (2) preparing an oil phase, wherein the oil phase contains divinylbenzene, methyl acrylate, benzoyl peroxide, tert-butyl peroxy-2-ethylhexanoate, triallyl isocyanurate, tripropanol alkyl trimethacrylate and methylbenzene, and the oil phase is uniformly stirred and mixed with the methylbenzene and the trivinylbenzene, the methyl acrylate, the benzoyl peroxide, the tert-butyl peroxy-2-ethylhexanoate, the triallyl isocyanurate, the tripropanol alkyl trimethacrylate and the methylbenzene; (3) suspension polymerization: putting the oil phase into the water phase, and carrying out staged heating reaction; (4) amination reaction; (5) alkylation reaction; and (6) acid-base alcohol treatment. Compared with the existing resin, the resin disclosed by the invention has the characteristics of high adsorption exchange rate, high desorption rate and high desorption concentration on ulinastatin, and the yield of ulinastatin is increased by 1.17 times compared with that of D215 resin.

The invention belongs to the technical field of organic porous materials, and relates to an acenaphthequinone diimine palladium functionalized super-crosslinked microporous polymer as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: carrying out Friedel-Crafts alkylation reaction on (1E, 2E)-N1, N2-bis [2, 4, 6-tri-(benzhydryl phenyl)] acenaphthylene-1, 2-diimine and dimethyl formal, 1, 3, 5-triphenylbenzene or tetraphenylmethane, so as to obtain an organic porous polymer; and carrying out coordination on the organic porous polymer and PdCl2 to obtain the acenaphthequinone diimine palladium functionalized super-crosslinked microporous polymer with catalytic activity. The super-crosslinked microporous polymer has the advantages of high stability, large specific surface area and high palladium loading capacity, and can catalyze the direct C-H bond arylation reaction of brominated aromatic hydrocarbon and heteroaromatic hydrocarbon to synthesize a linked heteroaryl compound; the preparation method of the organic porous polymer catalytic material is simple and suitable for industrial production.

The invention discloses a preparation method and application of an oil-soluble heteropolyacid ionic liquid catalyst. The catalyst is composed of organic cations and inorganic anions, the cations are one of quaternary ammonium, imidazole and pyridine cations containing long-chain alkyl, the anions are heteropolyacid anions, the long-chain alkyl enables the catalyst to have good oil solubility, the catalyst can be efficiently dispersed in the waste grease, heteropolyacid provides active sites, and the catalyst can be used for treating the waste grease. Nano-scale active particles are formed after in-situ vulcanization, and the catalytic hydrogenation effect is achieved. The invention also provides a preparation method of the oil-soluble heteropolyacid ionic liquid catalyst, the catalyst can be prepared from tertiary amine and halogenated hydrocarbon through three-step reaction of alkylation, anion exchange and acid-base neutralization, the preparation process is simple, a highly toxic reagent is avoided, and the cost is low. The catalyst provided by the invention can be used for catalytic hydroisomerization of various waste oils and fats, has the characteristics of high conversion rate, low coking rate and high product calorific value, and has relatively high industrial application potential.

The invention discloses a high-selectivity pyridine alkylation method which comprises the following steps: taking anhydrous titanium chloride and an anhydrous ferric chloride solution as raw materials, adding a dispersing agent, heating and uniformly stirring, adding ammonia water to adjust the pH value to a fixed value, grinding and sieving to obtain a catalyst carrier; dipping the catalyst carrier into a rare earth metal oxide solution dissolved by dilute sulphuric acid in an equivalent volume manner, aging, grinding and sieving to obtain a rare earth metal modified solid superacid catalyst; the method comprises the following steps: activating a rare earth metal modified solid superacid catalyst, cooling to a reaction temperature, filling a fluidized bed reaction tube with the catalyst, mixing pyridine and dimethyl carbonate, starting feeding, opening an air inlet valve, introducing nitrogen, and carrying out a reaction on the raw material mixed nitrogen in a catalyst layer to realize high-selectivity pyridine alkylation. Pyridine and a green methylation reagent dimethyl carbonate are used as raw materials, and high-selectivity synthesis of 2-methylpyridine can be realized under the action of a rare earth metal modified solid superacid catalyst.

The invention provides a preparation method of a Joule heat-assisted super-wetting metal net, a metal net with super-hydrophilic performance and a metal net with super-hydrophobic performance. According to the material, carbon nanotubes are firmly adhered to the surface of a metal net through polydopamine mediation to construct a micro-nano coarse structure, a hydrophobic alkyl compound is grafted through a sulfenyl three-component coupling reaction to reduce surface energy, and a super-hydrophilic / underwater super-oleophobic metal net and a super-hydrophobic metal net are prepared respectively. The Joule heating effect of the material is remarkably enhanced by introducing the carbon nanotubes, so that the temperature of the material can be rapidly increased to 100 DEG C or above within 20 seconds under the ultralow voltage of 2.0 V. The characteristic can be effectively used for in-situ heating viscosity reduction of high-viscosity crude oil, continuous and efficient oil-water separation is achieved in a double-channel separation device, the crude oil flux reaches up to about 3985 L.m <-2 >. H <-1 >, and the separation efficiency exceeds 98.6%. The method is also suitable for stainless steel meshes with micron-sized apertures, and can realize efficient separation of various crude oil emulsions.

The invention relates to the technical field of photoinitiators, and provides a triplet-triplet energy transfer (TTET) free radical I type photoinitiation system, a photocuring composition and application thereof. The system comprises a boron dialkylated dipyrromethene free radical I type photoinitiator and a long wave absorption photosensitizer, the photosensitizer is preferably an osmium (II) complex, and the mass ratio of the photosensitizer to the photoinitiator is preferably 1: 5-1: 200. Under the irradiation of a 650-750 nm light source (preferably a 690 nm LED), the photosensitizer enters a triplet state through intersystem crossing and generates TTET to the photoinitiator, so that the photoinitiator is uniformly split in the triplet state to generate free radicals, thereby initiating polymerization / cross-linking curing of monomers such as (methyl) acrylate and the like. The embodiment shows that the double bond conversion rate of the TPGDA can reach more than 80% within 10 minutes under the conditions of LED at 690 nm and 80 mW / cm < 2 >.

The invention relates to a synthesis method of a diunsaturated ester compound catalyzed by N-heterocyclic carbene, and belongs to the field of organic synthesis. According to the preparation method, the synergistic effect of N-heterocyclic carbene and light is utilized, gamma-oxo unsaturated aldehyde and Katritzky salt are taken as starting raw materials, the Katritzky salt generates alpha-ester free radicals through a single electron transfer process under the illumination condition, the free radicals react with a nucleophilic trienol intermediate generated through catalysis of the N-heterocyclic carbene, and the alpha-ester free radicals react with the nucleophilic trienol intermediate to generate the gamma-oxo unsaturated aldehyde. Target products are obtained with good yield and high regioselectivity, so that a series of epsilon-alkylated diunsaturated ester compounds are efficiently synthesized. The method is simple and convenient to operate, green and efficient, has the advantages of no transition metal participation, wide substrate applicability and the like, provides a new way for synthesis of the diunsaturated ester compound, and has a wide application prospect.

The present disclosure relates to a procedure for the synthesis of polymers (homo and copolymers) of the poly (ionic liquid) (PIL) type. The homopolymers are derived from polyvinylimidazolium, polyvinylpyrrolidone or polyvinylpyridine and the copolymers from monomers of vinyl ionic liquids (ILs) are derived from imidazole and N-vinylpyrrolidone. The structural modification of these homopolymers and copolymers occurs by using strong inorganic acids such as sulfuric, chlorosulfonic and bromosulfonic, among others, and halide metallic salts such as AlCl3, FeCl3, CuCl, ZnCl2, and SnCl2. Also, these PILs are employed as catalysts in alkylation reactions between isoparaffins and olefins for producing alkylate gasoline.

The application discloses a kind of rapamycin 40-position hydroxyl alkyl synthesis method, belong to the technical field of drug synthesis.The method is: in inert gas atmosphere, rapamycin is sequentially added into microwave reaction tube, molecular sieve and additive, additive is triphenyl phosphine oxide, tri (4-fluorophenyl) phosphine oxide, tri (4-methoxyphenyl) phosphine oxide, tricyclohexyl phosphine oxide, triphenyl phosphine sulfide, triphenyl phosphine selenide or hexamethylphosphorus triamide;Subsequently, alkylating agent, base and organic solvent are added, sealed, reacted in microwave reaction instrument, cooled, filtered, washed, dried, filtered, purified, to obtain the alkylated product of rapamycin 40-position hydroxyl group.The method compared with the existing rapamycin 40-position hydroxyl group alkyl modification method, simple operation, low cost, short reaction time, less impurities, easy separation, higher yield, up to 79.1%, suitable for industrial production, can provide new ideas for synthesis and development of rapamycin derivatives such as everolimus.

Provided are industrial processes for producing an organic acid alky ester from a feedstock containing organic acids and / or saponifiables, comprising: countercurrently contacting a feedstock with an organic alkylating reagent over two or more vessels or stages at temperature between 100° C. and 400° C. and pressure between 0.1 barg and 355 barg while simultaneously removing water and / or glycerin with unreacted alkylating reagent from the final vessel or stage to result in a first reaction method product containing organic acid alkyl esters, followed by a choice of using the alkyl esters as-is, purifying the organic acid alkyl esters from the first reaction product mixture or subjecting the first reaction product mixture to an additional transesterification reaction to convert saponifiables into additional organic acid alkyl esters, then purifying the organic acid alkyl esters from this second reaction method product.

The invention relates to the field of composite materials, and particularly discloses a bio-based silica gel material and a preparation method thereof.The preparation method comprises the following steps that S1, an alkylated castor oil derivative is prepared, specifically, castor oil and maleic anhydride serve as raw materials to react to generate castor oil-based polycarboxylic acid ester containing double bonds, then mixing and reacting with an amino silane coupling agent to prepare an alkylated castor oil derivative; s2, mixing the alkylated castor oil derivative prepared in the step S1 with vinyl silane, 4-hydroxy-3-methoxyphenylethylamine, hermetia illucens oil, a catalyst and a pretreatment filler, and carrying out a reaction to prepare a silane group; s3, hydrolytic polycondensation: adding water into the silane group prepared in the step S2, hydrolyzing under an acidic condition to generate a colloidal silica, and drying to obtain a silica gel material; the invention further discloses the bio-based silica gel material prepared by adopting the preparation method. The bio-based silica gel material has the characteristic of preparing the bio-based silica gel material with higher mechanical property and heat resistance.

The invention discloses a green and efficient carbonyl alkylation pyrrolo [1, 2-a] indole synthesis method, and relates to the technical field of organic synthesis. An alpha-bromocarbonyl compound is used as a carbonyl alkyl source, Ir (ppy) 3 is used as a photosensitizer, potassium hydroxide is used as alkali, sodium dimethyl dithiocarbamate is used as an additive, acetonitrile is used as a solvent, a carbonyl alkylation / cyclization reaction of N-alkenyl substituted indole is realized under the condition of visible light, and corresponding carbonyl alkylation pyrrolo [1, 2-a] indole is obtained. The method is convenient to operate, green and efficient in reaction and wide in substrate applicability.

A process of producing jet fuel is disclosed. The process comprises separating lignin from a lignocellulosic biomass to provide a lignin stream. The lignin stream is pyrolyzed and / or hydrotreated to produce an aromatic rich bio-oil stream. The aromatics in the aromatic rich bio-oil stream are alkylated with an alkylating agent to produce an alkylated aromatic product stream. The alkylating agent can be taken from the lignocellulosic biomass. The process produces a green jet fuel.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.