130 results about "Quaternary" patented technology

A receiver generates log-likelihood-ratio-based soft bit metrics of precoded quaternary continuous phase modulation signals using four state-constrained trellises and a streamlined maximum likelihood sequence estimation Viterbi algorithm requiring no survivor state storage elements for a preferred error correction-coded quaternary Gaussian minimum shift keying communication system employing reduced-complexity pulse-amplitude modulation matched-filtering and soft-decision decoding.

A cationic polymer salt composition is provided that includes a reaction product derived from reaction of a polyamine or a polyalkyleneimine and a substituted alkyl trialkyl quaternary ammonium salt. Also provided are surfactant compositions. The compositions may also include carriers, such as water, methanol, ethanol, propanol, isopropanol, butanol, isobutanol, monoethyleneglycol, an ethyleneglycol monobutyl ether, and hexylene glycol.

The present invention is one kind of chemical fiber with plasma process grafted quaternary ammonium group and its grafting process. The process includes treating chemical fiber in a corona discharge electric field of 3000-12000 V voltage and 10-500 W power for the surface of the fiber to produce free radical or ion group, soaking the fiber in water solution of double bond-containing quaternary ammonium monomer for grafting polymerization reaction to graft cationic group, eliminating un-reacted monomer, washing, oiling and drying to obtain modified chemical fiber containing cationic quaternary ammonium group.

The invention relates to reactive beta-cyclodextrin quaternary ammonium salt as well as a preparation method and application thereof. The reactive beta-cyclodextrin quaternary ammonium salt is synthesized through two steps, namely, step 1, taking beta-cyclodextrin, choline chloride and epoxy chloropropane as raw materials to be subjected a ring opening substitution reaction to generate beta-cyclodextrin quaternary ammonium salt; step 2, taking the beta-cyclodextrin quaternary ammonium salt and a compound as raw materials to be subjected to a substitution reaction to generate the reactive beta-cyclodextrin quaternary ammonium salt. The reactive beta-cyclodextrin quaternary ammonium salt has no toxic or side effect; when being used for salt-free dyeing of an active dyestuff of cotton fabric, the reactive beta-cyclodextrin quaternary ammonium salt has relatively good dyeing effect; the pollution to the environment by salt in wastewater is reduced and treatment pressure of dyeing and finishing wastewater is alleviated; the dyed fabric has relatively good dyeing effect; the dyeing rate of the active dyestuff is 65 percent to 85 percent and the color fixation rate is 55 percent to 70 percent; the dry rubbing fastness is more than grade 4 and the wet rubbing fastness is more than grade 3.

The invention relates to a reactive chitosan quaternary ammonium salt, and a preparation method and application thereof. The preparation method comprises the following steps: carrying out Friedel-Crafts reaction on chitosan and 2,3-epoxy propyl-trimethyl ammonium chloride to generate N-2-hydroxypropyltrimethyl ammonium chloride chitosan, and carrying out substitution reaction on the N-2-hydroxypropyltrimethyl ammonium chloride chitosan and a compound to generate the reactive chitosan quaternary ammonium salt. The reactive chitosan quaternary ammonium salt is an aid for reactive dye cotton fabric salt-free dyeing, is soluble in water, and has the advantages of no toxic or side effect and favorable environment friendliness. When being used for reactive dye salt-free dyeing of cotton fabrics, the reactive chitosan quaternary ammonium salt has favorable dyeing effects, reduces the environmental pollution of salts in wastewater, and greatly lowers the dye printing production cost. When the reactive chitosan quaternary ammonium salt is used in the dyeing process to obtain the cotton fabric, the dye-uptake rate of the reactive dye is 70-85%. The fixation rate is 47-55%, the dry fastness to rubbing is greater than Grade 4, and the wet fastness to rubbing is greater than Grade 3.

A personal care composition is provided formulated with glycerin and a moisturization enhancing agent which is a salt of structure AB, wherein A is a cationic charged component, B is an anionic charged component, and A has at least one quaternized nitrogen atom and at least two hydroxyl groups and a molecular weight no higher than about 400.

The invention relates to compound quaternary ammonium salt disinfectant, which comprises dodecyldimethylbenzylammonium serving as a germicide, a double long-chain quaternary ammonium salt with high interference resistance and a synergist. The main technical characteristics of the compound quaternary ammonium salt disinfectant is the adoption of the high-safety mild and nonirritating poly(quaternary ammonium salt) which is formed by grafting C11 to C18 long-chain alkyl on the surface of an amino-terminated hyperbranched quaternary ammonium salt compound. The disinfectant can quickly kill board-spectrum fungi, saccharomycetes, mould, Escherichia coli, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, virus and the like; with disinfection concentration, the disinfectant is low in toxicity and irritability; being noncorrosive, the disinfectant avoids corroding pipes made of stainless steel, copper, aluminum and the like; and the disinfectant has high biodegradability, avoids polluting the environment and meets requirements for environment protection. The disinfectant can be used for disinfecting surfaces of common objects and disinfecting food processing equipment, cotton and chemical fiber textiles, skin, adhesive films and the like.

The invention discloses a quaternary deep well layered water pumping and stopping device and a water pumping and stopping method thereof. The device comprises a drilling rod connecting head, a pumpingchamber pipe arranged at the lower portion of the drilling rod connecting head, a water guiding pipe arranged at the lower portion of the pumping chamber pipe, a rubber water stopping air bag arranged on the outer wall of the upper portion of the water guiding pipe, and a rubber water stopping plug arranged on the outer wall of the lower portion of the water guiding pipe. A using method comprisesthe steps of 1), hole drilling and sampling analysis; 2), well drilling; 3), hole punching; 4), well pipe installing; 5), gravel filling and water stopping; 6), well washing; 7), water pumping testing. The deep well layered water stopping device is simple in structure, the defects existing in traditional water stopping methods are overcome, the operation is convenient, the water stopping effect is reliable through actual use, and upper and lower water-containing layers are effectively isolated so that layered water stopping in a pipe in the same well hole can be achieved to achieve the purpose of layered water pumping testing. The layered water pumping and stopping device and method are suitable for performing observation and water pumping testing on different water-containing layers whenhydrographical drilling is conducted.

The invention discloses a target quaternary ammonium salt cationic polymer lipid gene carrier, a preparation method and an application thereof. The target quaternary ammonium salt cationic polymer lipid genetic carrier is characterized in that: a polymeric quaternary ammonium salt and lipid are adopted for preparing a quaternary ammonium salt cationic polymer lipid genetic carrier according to a mass ratio, wherein the mass ratio of the polymeric quaternary ammonium salt to the lipid is 0.05-20:1; then a assembly method or a modification method is adopted for modifying to prepare a folic acid or EGFR antibody modified cationic polymer lipid gene carrier. Results of gene transfection experiments show that: gene transfection efficiencies of the target quaternary ammonium salt cationic polymer lipid gene carrier in 293T cells and NIH-3T3 cells are the same as the gene transfection efficiencies of positive control lipofectamine of lipofectamine<TM>2000 in the 293T cells and the NIH-3T3 cells; the gene transfection efficiencies of the EGFR antibody modified cationic polymer lipid genetic carrier in liver cancer Huh-7 cells and breast cancer MCF-7 cells are higher than the gene transfection efficiencies of the lipofectamine<TM>2000 in the liver cancer Huh-7 cells and the breast cancer MCF-7 cells. The cationic polymer lipid genetic carrier system provided by the present invention has good biocompatibility and low cytotoxicity, and can be as an excellent non-viral gene delivery carrier.

The invention belongs to the technical field of nano-particles, and relates to self-assembly nano-particles of a sulfhydrylation chitosan quaternary ammonium salt and a preparation method and application thereof. The sulfhydrylation chitosan quaternary ammonium salt is prepared from chitosan through quaterisation and sulfhydrylation modifications in turn. The nano-particles are generated from the positively charged sulfhydrylation chitosan quaternary ammonium salt and a negatively charged protein polypeptide medicament or a nucleic acid medicament through polyelectrolyte action. Compared with the prior art, the invention has the advantages that: the preparation process of the nano-particles is simple and easy to control, organic solvent is not needed, and the stability of medicaments can be effectively improved. Compared with the conventional chitosan quaternary ammonium salt nano particles, the nano-particles have better effects of promoting absorption of the protein medicament and promoting cell transfection of the nucleic acid medicament.

The invention relates to an anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt. The composite bone cement is prepared by mixing HACC, PMMA and bone cement monomers, wherein the mass ratio of the HACC and the PMMA is 15-30%. The invention also provides a preparation method and applications for the composite bone cement. The invention has the advantages that the PMMA of the composite HACC can replace the current frequently-used PMMA antibiotic bead chain, can be applied to bone defect filling, infection prevention, treatment of chronic osteomyelitis and centrum reinforcement of osteoporosis, achieves the antimicrobial activity similar to the antibiotic bone cement, simultaneously avoids the generation of antibiotic resistance, can be used for patients with resistance to antibiotics, and has larger clinical application values; and appropriate reduction of elastic modulus is also beneficial to reducing the non-uniform stress distribution of a cured centrum and an adjacent centrum section, thus relieving the early degeneration of adjacent intervertebral disk and fracture of adjacent centrums.

The invention provides a quaternary array micro-electromechanical system (MEMS) vector hydrophone microstructure. The quaternary array MEMS vector hydrophone microstructure comprises a square substrate, wherein four cross-shaped cantilever beams are etched on the square substrate, a minitype cylindrical object is fixed in the center of each cross-shaped cantilever beam, and voltage dependent resistors are arranged on the cross-shaped cantilever beams. Included angles between the four cross-shaped cantilever beams and the square substrate are different with each other and are respectively 0 degree, 30 degrees, 45 degrees and 60 degrees. The quaternary array MEMS vector hydrophone microstructure is made through the MEMS technology and has the advantages of being highly sensitive, low in energy consumption and micro in size. Compared with the single vector hydrophone, a hydrophone made of the quaternary array MEMS vector hydrophone microstructure is high in directional accuracy, strong in space resolution ratio power and capable of solving the problem of port and starboard ambiguity. Compared with the traditional hydrophone array, the size of the array of the quaternary array MEMS vector hydrophone microstructure is greatly reduced. The quaternary array MEMS vector hydrophone microstructure is integrally formed through the MEMS technology, high consistency exists among array elements, and burden on calculation of sequential arithmetic is lightened.

The invention discloses spirocyclo-quaternary ammonium salt for a supercapacitor and a preparation method of the spirocyclo-quaternary ammonium salt. The spirocyclo-quaternary ammonium salt for the supercapacitor is characterized in that the formula is represented as following, wherein in (A), n, m= 1, 2, 3; in (B) or (C), n, m= 1, 2, 3; and p=1, 2. The preparation method includes that water is used as a reaction medium, cyclic amine and dihalogenation amine or glycol di-sulphonate ester are subjected to condensation reaction under the action of alkali, and obtained spirocyclo-quaternary ammonium salt and lithium bis(oxalato)borate are subjected to ion exchanging and then to purification to obtain the target spirocyclo-quaternary ammonium salt. According to the spirocyclo-quaternary ammonium salt for the supercapacitor and the preparation method of the spirocyclo-quaternary ammonium salt, raw materials are easily obtained, reaction selectivity is good, qualities of the spirocyclo-quaternary ammonium salt are high, and the method is suitable for large scale production, and the supercapacitor which is composed of the spirocyclo-quaternary ammonium salt is low in internal resistance, high in electrostatic capacity and excellent in cycling performances.

The invention is concerned with chronology research determination technology field about the Quaternary epoch, geography, disaster, archeology, especially a alpha recoil track determining age method, including: a) sample collection; b) observation sample preparation; c) etch observation sample; d) observation sample equipment; e) statistic alpha recoil track value; f) measure vertical etching speed; g) determine alpha recoil track body density; h) determine the uranium thorium content of the mica sample; i) compute the alpha recoil track age of the mica.

The invention relates to the field of daily chemicals and in particular relates to a shampoo composition. The shampoo composition comprises the following components: imidazoline surfactants, amino acid surfactants, cation quaternary fructooligosaccharides, plant amino acids and water. The weight of the imidazoline surfactants accounts for 0.01% to 10% of the total weight of the shampoo composition, the weight of the amino acid surfactants accounts for 0.01% to 10% of the total weight of the shampoo composition, the weight of the cation quaternary fructooligosaccharides accounts for 0.01% to 5% of the total weight of the shampoo composition, and the weight of the plant amino acids accounts for 0.01% to 5% of the total weight of the shampoo composition. The shampoo composition further comprises surfactants, non-volatile siloxane, cation polymers, suspension stabilizers, additives and optionally anti-dandruff and antipruritic agents. The shampoo composition causes less irritation to the scalp and enhances conditioning property of the scalp.

An injectable pH-sensitive chitosan quaternary ammonium salt hydrogel is prepared through reaction between chitosan and 2.3-epoxypropyl ammonium trimethylchloride, depositing in acetone, washing, baking to obtain chitosan quatemary ammonium salt, dissolving it in acidic solution, dripping the solution of glycerine phosphate while stirring, and heating for gelatinizing.

The present invention provides a branched poly quaternary ammonium salt (PQAS). The present invention further provides a method for synthesizing the PQAS, wherein branched polyethyleneimine is subjected to an aminomethylation reaction to obtain methylated branched polyethyleneimine, and the methylated branched polyethyleneimine reacts with a halogenated compound to obtain the PQAS. According to the present invention, the method has characteristics of rapidness, efficiency, low cost, simple process and high yield; and the PQAS has the contact type bactericidal capacity, the internal branched structure can embed the guest molecules such as antibiotics, dyes and the like to form the slow release type bactericidal capacity, and the compatibility between the PQAS and the water or resin can be adjusted with different halogenated compounds, such that the PQAS can be used in the fields of antibacterial lotion and material formula, dyeing formulas of plastics, coating materials or films, and the like.

The invention provides a preparation method of a carboxymethyl chitosan quaternary ammonium salt / organic rectorite nano composite material and an application thereof. The carboxymethyl chitosan quaternary ammonium salt / organic rectorite nano composite material comprises the basis components of carboxymethyl chitosan quaternary ammonium salt and organic rectorite, and is generated by intercalating the carboxymethyl chitosan quaternary ammonium salt layer between the organic rectorite layers, wherein the distance between the intercalated organic rectorite layers is 4.2-4.72 nm. The preparation method comprises the following steps: dropwise adding the carboxymethyl chitosan quaternary ammonium salt solution of a certain concentration to the organic rectorite aqueous suspension under the condition of stirring at 70-80 DEG C, and then freezing and drying to obtain the nano composite material carboxymethyl chitosan quaternary ammonium salt / organic rectorite. The nano composite material can be used as a drug carrier, has the advantages of both the carboxymethyl chitosan quaternary ammonium salt and the organic rectorite, the drug control-release capability of the nano composite material is superior to that of the single carboxymethyl chitosan quaternary ammonium salt, and the heat resistance of the nano composite material is also significantly improved compared with that of the carboxymethyl chitosan quaternary ammonium salt.

The invention relates to a method for detecting the cationic surfactants of alkyl quaternary ammonium salts with the liquid chromatography-tandem mass spectrometry and includes the following steps: pre-treating the detected samples with a Soxhlet extraction method or a supersonic extraction method; detecting with a liquid chromatograph-tandem mass spectrometer with the LC conditions of a C18 reverse-phase chromatographic column, a column temperature of 30 to 60 DEG C, the inlet volume of 3 to 10ul, the mobile phase flow rate of 0.15 to 0.60ml per minute; the tandem mass spectrometry MS / MS is provided with the conditions of ionizing by adopting the electro-spray ionization model and the detection mode of multi-ion reaction. The method adopted by the invention is characterized by accurate and fast analysis method, high method selectivity, little interference, etc.

The invention relates to a process for preparation of a dialkyl acidamide imidazoline quaternaries paper softening agent, which comprises steps of: a, synthesizing the dialkyl acidamide imidazoline, that is, charging stearic acid into a four-way flask for heating and melting, then after the stearic acid is melted charging catalyzer and nitrogen for protection, slowly dropping diethylenetriamine for reaction to obtain the dialkyl acidamide imidazoline; b, preparing the paper softening agent of the invention, that is, charging the dialkyl acidamide imidazoline prepared in the first step into a three-way flask, charging alcohol isopropylicum, evenly mixing, then gradually dropping dimethyl sulfate, and keeping the temperature for a while to obtain the softening agent. The paper softening agent of the invention is characterized by the softening properties of both acidamide type and quaternaries type and strong fiber absorption ability, can greatly lower interfiber static friction coefficient, and has a smooth hand feeling.

The invention relates to a chitosan quaternary ammonium salt hydrogel antibacterial dressing and a preparation method thereof, and belongs to the field of biomedicine. The chitosan quaternary ammoniumsalt hydrogel antibacterial dressing is prepared from the following raw materials in parts by weight: 0.1-5 parts of a chitosan quaternary ammonium salt, 0.1-5 parts of an organosilicon quaternary ammonium salt, 1-8 parts of a cellulose derivative, 5-20 parts of glycerol and 80-120 parts of purified water. The chitosan quaternary ammonium salt hydrogel antibacterial dressing provided by the invention has a good antibacterial effect, stability and a wide application range, and has a good therapeutic effect on wound healing.

The invention relates to a preparation method of an antimicrobial bacterial cellulose material. The method comprises the following steps: adding an organosilicon quaternary ammonium salt into a solvent to obtain an organosilicon quaternary ammonium salt solution; and adding the organosilicon quaternary ammonium salt solution into a bacterial cellulose hydrogel, regulating the pH value to 2.0-7.0, carrying out stirring or oscillating reaction at 5-95 DEG C for 24-72 hours, and cleaning. The method is simple to operate and mild in conditions; and the grafting reaction occurs on the fiber surface, so that the grafting ratio is high. The graft-modified bacterial cellulose material has the advantages of bacterial resistance, protein adsorptivity, cell adhesion promotion characteristic, and specific pH responsivity and temperature responsivity. The antimicrobial bacterial cellulose material has excellent resistance to Staphylococcus aureus and other bacteria, is beneficial to adhesion and growth of the cells in the material, and enhances the application potential of the bacterial cellulose material in the fields of antimicrobial wound dressings, intelligent responsive drug-slow-release carriers, tissue engineering stent biomedicine and the like.

The invention discloses a functional composite fiber and a preparation method thereof. The functional composite fiber comprises 15wt%-45wt% of silicon dioxide and 0.5wt%-10wt% of chitosan quaternary ammonium salt. The preparation method comprises the following steps: (1) preparing an antiseptic solution from the chitosan quaternary ammonium salt, deionized water and sodium hydroxide; (2) preparing alkali cellulose from cellulose pulp, yellowing the alkali cellulose and dissolving the yellowed alkali cellulose in a sodium hydroxide solution of the silicon dioxide, wherein the solid content of spinning viscose containing silicon dioxide is 9.5wt%-11.5wt%; (3) adding the antiseptic solution into the viscose solution containing silicon dioxide in any step from yellowing to spinning to prepare a blended viscose solution, wherein the weight of the chitosan quaternary ammonium salt in the added antiseptic solution accounts for 0.5%-10% of that of the solid in the viscose solution; and (4) performing spinning forming and after-treating on the blended viscose solution to obtain the functional composite fiber. The functional composite fiber prepared by the method has both flame retardant and antibacterial properties.

The invention relates to a blue stain and mildew preventing processing method for masson pine timber. The method comprises the steps of: agitating 0.05-0.15% of thiophanate-methyl, 0.05-0.15% of carbendazim and 0.50-1.00% of double alkyl chain quaternary ammonium salt, with a solvent which is water or 75% alcohol uniformly to prepare a blue stain and mildew preventing liquid for masson pine timber; then quenching the masson pine timber naturally dried by the blue stain and mildew preventing liquid for masson pine timber for 10-20min; or processing fresh pine by way of painting or spraying, naturally drying the fresh pine and spraying for 2-3 times, and then stacking the masson pine timber processed by the blue stain and mildew preventing liquid for masson pine timber in an open type and naturally drying. The method provided by the invention can effectively inhibit propagation of various blue-stain fungi and moulds on the masson pine timber, has remarkable antibacterial effect and is simple in operational process with low processing cost, low using concentration of insecticide and low toxicity.

The invention relates to an improved combined microbe repairing agent for aquaculture environment regulation and belongs to the field of category of microbial preparations. The repairing agent consists of a surfactant and multiple microbes, wherein the surfactant accounts for 5-15wt% of the repairing agent; the surfactant comprises palm quaternary ammonium salt, magnesium laurate and gemini-based coconut oil betaine which are mixed at a ratio of 1:1:1 by adding a diluent; each microbe accounts for the following percent in total mass of the microbes: 20-40 percent of bacillus subtilis, 20-40 percent of lactic acid bacteria, 10-30 percent of candida, 5-10 percent of denitrifying bacteria and 5-10 percent of photosynthetic bacteria. The repairing agent is prepared at a certain ratio, and the composite microbes are uniformly distributed in the aquatic environment, so that dissolved oxygen in water is increased, the dominant bacterial community is rapidly formed in a water body, high-activity biological enzymes are generated, decomposition of residual feeds is accelerated, the growth of harmful bacteria is suppressed, and production of green aquatic products is ensured.

The invention relates to a softener comprising the following components in percentage by mass: 20-31% of chlorohydrocarbonyl functional group silane, 5-8% of double-alkyl dimethyl quaternary ammonium salt, 11-15% of methyl sulfate, 3-6% of calcium halogenide and 40-61% of deionized water. The mass percentage of all the raw material components is 23:7:13:5:52. The chlorohydrocarbonyl functional group silane is gamma-choropropyltrimethoxysilane. The methyl sulfate is imidazolinium methyl sulfate. The calcium halogenide is calcium chloride. The softener provided by the invention has the advantages that soft and fluffy effects are good after fabrics are sterilized and washed; the use concentration is low, so that the fabrics can not be damaged; the softener is good in stability, free of injury to skins, low in cost and free of pollution to the environment; the softener has a strong killing effect on common harmful microorganisms and particularly pathogenic bacteria, and the fabrics contain no bacteria after being washed; the fabrics are good in anti-static performance and remixed wettability and free of damage and yellowing phenomena.

The invention discloses nano chitosan base quaternary alkyl ammonium starch ether compound antibacterial paper, preparation and application thereof. The preparation method comprises the following steps: carrying out acid dissolution on chitosan, and mixing with a TPP solution to obtain nano chitosan; pasting a quaternary alkyl ammonium starch ether solution to obtain a quaternary alkyl ammonium starch ether pasting liquid; adding the nano chitosan into the quaternary alkyl ammonium starch ether pasting liquid to prepare a nano chitosan base quaternary alkyl ammonium starch ether compound papermaking dry strength agent with an antibacterial property, and adding the solution into paper pulp for papermaking. According to the preparation method, the nano chitosan is added into the quaternary alkyl ammonium starch ether pasting liquid, so that the nano chitosan can better give play to the antibacterial property; quaternary alkyl ammonium starch ether is added, so that the physical strength of the bacterial paper is remarkably improved; the nano chitosan base quaternary alkyl ammonium starch ether compound antibacterial paper is good in antibacterial property and excellent in physical property, and can be well applied to various fields like paper for daily use, food wrap paper and medicated paper.

The invention discloses a quaternary cross array acoustic detecting system for an underwater glider, and relates to the field of marine environmental detecting equipment. According the quaternary cross array acoustic detecting system, the problem that in an existing marine environmental detecting system, vertical dimension information of ambient ocean noise with different ocean depths cannot be obtained in a large scale is solved. Four sound pressure hydrophones are all used for obtaining ocean surface vertical dimension sound pressure signals and sending the signals to a datum collecting andstorage module; the four sound pressure hydrophones are respectively fixed to the four wingtips of the empennage of the underwater glider; and the datum collecting and storage module is used for collecting and storing vertical dimension sound pressure signals in the process of underwater vertical section movement of the underwater glider. The quaternary cross array acoustic detecting system for the underwater glider is used for obtaining vertical dimensional marine environmental acoustic information.

The present invention belongs to the technical field of nanoparticle, and particularly relates to a mannose-modified thiolated chitosan quaternary ammonium salt nanoparticle, a preparation method and application thereof. The nanoparticle of the invention is generated through polyelectrolyte effect between mannose-modified thiolated chitosan quaternary ammonium salt with positive charges and mannose-modified thiolated chitosan quaternary ammonium salt with negative charges. Simultaneously the nanoparticle loads protein peptide medicine or nucleic acid medicine with negative charges, wherein the mannose-modified thiolated chitosan quaternary ammonium salt is obtained from amino-groups of the chitosan through quaternizing, mannose ligand and sulfhydrylation modification successively. The nanoparticle has the following advantages: no requirement for organic solvent in preparation process, and effectively improved medicine stability. The nanoparticle can actively target intestinal epithelial cells, M cells and macrophages. Intestinal absorption for the oral medicine and transfection efficiency of the nucleic acid medicine are effectively improved. The effect of the mannose-modified thiolated chitosan quaternary ammonium salt nanoparticle is much better than that of the prior-art chitosan nanoparticle.