92 results about "Chronic osteomyelitis" patented technology

The invention belongs to the field of the traditional Chinese medicine preparation, in particular to a traditional Chinese medicine combination for treating chronic osteomyelitis and a preparation method thereof. The traditional Chinese medicine combination is prepared by the following raw materials by weight proportion: 5-12 parts of saffron, 50-80 parts of gardenia, 80-95 parts of honeysuckle, 40-50 parts of frankincense, 30-40 parts of myrrh, 40-50 parts of radix astragali, 35-45 parts of ground beetle, 15-25 parts of leech, 28-36 parts of scorpion and 30-40 parts of liquorice. The invention has simple prescription, simple preparation method and convenient use; when the medicine is used for treatment, patients almost have no suffering and are willing to accept; the invention has realistic and reliable curative effect and low cost, can remarkably enhance the cure rate and recovery rate of chronic osteomyelitis and is worthy of clinical popularization. .

The invention discloses use of a reagent for detecting the expression level of a C19orf43 protein from a serum exosome as a marker for diagnosing osteosarcoma. The maker can realize reliable diagnosis, particularly realizes distinguishing of osteosarcoma, chronic pyogenic osteomyelitis, Ewing's sarcoma, metastatic tumor of bone and osteoarticular tuberculosis. Furthermore the invention provides aninstant detecting platform of the exosome protein for detecting the marker. The method has advantages of high efficiency, simple operation, low cost and high clinical auxiliary diagnosis value.

The present invention provides a bone infection preventing and treating composite bone cement, which comprises, by mass, 0.5-70 wt% of magnesium-based metal particles, 10-95 wt% of a calcium phosphate bone cement matrix, and 1-60 wt% of a curing liquid. According to the bone infection preventing and treating composite bone cement of the present invention, the calcium phosphate bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used antibiotic-loaded calcium phosphate bone cement matrix so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability is far higher than the antibacterial capability of the traditional bone cement and achieves the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement while the generation of the antibiotic resistance is avoided; the bone infection preventing and treating composite bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the composite bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

The invention provides ointment for treating acute and chronic osteomyelitis and a preparation method thereof. The ointment is prepared from the following components in parts by weight: 600-1000 parts of sesame oil, 60-100 parts of mulberry twig, 60-100 parts of willow twig, 60-100 parts of peach twig, 60-100 parts of elm twig, 60-100 parts of pagoda tree twig, 180-200 parts of minium, 100-120 parts of frankincense, 100-120 parts of myrrh, 30-60 parts of Chinese angelica, 30-60 parts of salvia miltiorrhiza, 30-60 parts of scutellaria baicalensis, 30-60 parts of cortex phellodendri and 30-60 parts of coptis chinensis. The ointment has the effects of promoting growth of renewal skin, activating blood circulation to remove stasis, clearing heat and diminishing swelling and the like, can be directly applied to an affected part, and has the advantages of quick response, safety and reliability, convenience in use and long storage time.

An implantative calcium sulfate-based local releasing system for treating chronic osteomyelitis and osteocarcinoma is proportionally prepared from calcium sulfate, polymer disperser, and medicine through mixing, adding physiologic soline, stirring, die pressing and vacuum drying.

The invention discloses an osteopathia rehabilitation pill for treating chronic osteomyelitis. The osteopathia rehabilitation pill is mainly prepared from the following raw medicinal materials in parts by weight: 150 to 170 parts of astragalus membranaceus, 95 to 115 parts of angelica sinensis, 45 to 60 parts of rhizoma atractylodis, 45 to 60 parts of poria cocos, 75 to 95 parts of semen coicis, 100 to 120 parts of honeysuckle, 105 to 115 parts of codonopsis pilosula, 45 to 60 parts of radix paeoniae alba, 80 to 90 parts of dandelion, 45 to 60 parts of pericarpium citri reticulatae, 25 to 40 parts of licorice root, 50 to 65 parts of wolfberry fruit and 50 to 65 parts of prepared radix rehmanniae. The osteopathia rehabilitation pill which is used for treating the chronic osteomyelitis is short in treatment time, free of side effect and obvious in treatment effect and has the total effective rate being above 90%.

The invention relates to the field of traditional Chinese medicine, and discloses a compound coptis chinensis liquid which is prepared by using coptis chinensis, scutellaria baicalensis, golden cypress, jasmine, garden burnet, rheum officinale, astragalus mongholicus and borneol as raw materials and boiling in water and extracting. The compound coptis chinensis liquid has a good effect in treating chronic osteomyelitis and acute soft tissue injury, reduces the production cost, is simple and convenient to use, wide in application range and convenient to store and popularize.

The invention provides a sustained-release injection or sustained-release implant containing lincomycin antibiotic. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from poly(ethylene-co-vinylacetate) (EVAc), polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.

The invention discloses an external Chinese medicinal ointment for treating chronic osteomyelitis. The chronic osteomyelitis belongs to the range of the traditional Chinese medicine suppurative osteomyelitis, and the suppurative osteomyelitis is mostly caused by the process of external injury fracture, Qi-stagnation and blood stasis, lasting stasis, heat, heated body fluid, fester. Therefore, plyas mucosus root, radix ampelopsis, bovista, broomjutre sida herb, cardiospermum with small fruit, beautyberry leaf, catecholamine, pearl and hydrargyrum oxydatum crudum with the function of promoting blood circulation and removing blood stasis, clearing away heat and toxic materials, building the body and removing pus, removing necrotic tissue and promoting granulation are prepared into powder in the manufacturing laboratory of the hospital, the powder is prepared into the ointment via the sesame oil, and then the ointment is infiltrated by the sterile gauze strip for preparing the traditional Chinese medicine gauze strip for external use on the surface of the wound or internal use for the wound antrum. After clinical trials, the total effective rate is 97.9% and relapse is eliminated.

The invention discloses a medicine for treating chronic osteomyelitis and a preparation method of the medicine, and belongs to the field of traditional Chinese medicines. Raw materials of effective components of the medicine comprise Japanese polygala, Japanese violet herb or root, humulus japonicus, cantonese ampelopsis, aeginetia indica, radix isatidis, eucommia ulmoides, araliaceae acanthopanax trifoliatus, abelmosk, cuneate lespedeza herb with root, wallich pepper stem and leaf, lamium amplexicaule, licorice, obscured homalomena rhizome, ambrosia artemisiifolia and elk's horn. The medicine is appropriate in compatibility, is prepared according to the property of the medicine to achieve the functions of treating both symptoms and root causes, promoting blood circulation, regulating vital energy, dispersing blood stasis and removing toxicity, is good in absorption effect, remarkable in treatment effect, safe, reliable and free from toxic and side effects and clinical adverse reaction, has the extremely good treatment effect on the chronic osteomyelitis, is capable of obviously improving the immunity of a human body, and can be widely applied to clinical treatment of the chronic osteomyelitis.

An application of shrubby dendrotrophe twigs is preparing the medicines for treating allergic dermatitis, urticaria, bone tuberculosis, lymph tuberculosis, skin tuberculosis, chronic osteomyelitis, etc is disclosed.

The invention discloses a sustained release injection containing mezlocillin, which consists of sustained release microspheres and menstruum, wherein, the sustained release microspheres contain sustained release excipient and penicillin antibiotics, the menstruum is special menstruum containing suspending agents such as sodium carboxymethyl cellulose and so on, and the viscosity is between 100 and 3000cp (at the temperature of between 20 and 30 DEG C); the sustained release excipient is selected from EVAc, polifeprosan, PLA, PLGA, decanedioic acid copolymers, albumin glue, gelatin and so on; and the sustained release microspheres can also be prepared into sustained release implant. The sustained release implant and the sustained release injection are locally placed or injected on a bacteria focus, which can slowly release medicine at a local lesion for 5 to 30 days and apparently decrease the systemic toxicity of the medicine when the effective medicine concentration of the local lesion is effectively obtained and maintained. The sustained release injection has a remarkable and unique treatment effect on infections caused by staphylococcus, streptococcus, peptostreptococcus, acne propionate bacillus, enterobacter, tubercle bacillus, gonococcus or meningococcus and so on, particularly on local lesions such as chronic osteomyelitis, severe bedsore, refractory skin ulcer, diabetic foot and femoral head necrosis of diabetes, and various abscesses and so on.

The invention discloses a traditional Chinese medicinal external application agent for treating chronic osteomyelitis. Chronic osteomyelitis has many causes, such as physique weakness, intense internal heat, kidney essence deficiency, cold dampness evil and physique weakness, deep invasion Fu junction, chronic depression transforming heat, damp heat evil stagnation in meridians and qi blood, and suppuration injury to bone. Botrychium virginianum, Root of Tubeflower Duchmans pipe, Leaf of Pubescent Holly, Arabis pendula L., glomeris, Leaf of Ivy tree, Plumbago auriculata, Rhaphidophora decursiva, laevigate elatostema herb, Maesa perlarius (Lour.)Merr. and root of bengal clockvine are selected and are processed through a traditional making technology to prepare an ointment. Clinic tests of the ointment show that the total effective rate is 85.4% and is obvious better than that of a control group (68.7%), and the clinic effect is good.

The invention provides a traditional Chinese medicine formula for treating acute/chronic osteomyelitis. The formula is composed of the following raw materials: coptis, radix astragali, licorice, viola japonica, cornu cervi degelatinatum, honeysuckle flower, poria cocos, live earthworm, and semen cuscutae. The invention further provides a preparation method and application method of the traditional Chinese medicine formula. On the basis of traditional Chinese medicine theory and clinical experience, the herbals and weight ratio are determined, the synergetic effect or resistance effect among the components is utilized to improve the curative effect, and the traditional Chinese medicine formula has the advantages of prominent curative effect, short treatment course, low cost, and no side or toxic effect, and can treat both the root and symptoms of osteomyelitis. The traditional Chinese medicine formula has the functions of moving qi and promoting blood circulation, thus can supply enough blood to bones and soft tissues; furthermore, has the functions of activating blood circulation to remove blood stasis, activating collaterals, and freeing veins, and thus can free the collaterals around bones and promote the blood circulation, so the toxicity in the affected parts is reduced, the immunity is enhanced, and osteomyelitis can be radically cured.

The invention discloses a Chinese medicine for preventing and treating chronic osteomyelitis and a preparation method thereof, and belongs to the field of Chinese medicines. The medicine disclosed by the invention comprises the following effective ingredients of raw materials in parts by weight: 60 parts of dandelion, 60 parts of angelica sinensis, 53 parts of radix paeoniae alba, 52 parts of siam psychotria herb, 48 parts of honeysuckle, 45 parts of astragalus membranaceus, 45 parts of rehmanniae vaporata, 40 parts of parasitic loranthus, 40 parts of liquorice, 35 parts of tuckahoe, 32 parts of hematoxylon, 25 parts of huangcipi (Chinese character), 25 parts of rhizoma drynariae, 24 parts of myrrh, 20 parts of radix angelicae, 18 parts of spina gleditsiae, 14 parts of endothelium corneum gigeriae galli, 13 parts of swimming bladder, 15 parts of cicada slough, 12 parts of cartialgenous, 9 parts of scorpio, 7 parts of cinnamon, 4.5 parts of sting worm and 5 parts of cuttlebone. The Chinese medicine selects the medicinal materials according to the principles of monarch, minister, assistant and guide, and is elaborately prepared, and medicaments in the full formula have the effects of nourishing and purging, treating both symptoms and root causes, promoting and nourishing qi and blood, boosting essence and filling marrow, tonifying spleen and kidney, strengthening body resistance and eliminating evil, and promoting tissue regeneration, and have significant curative effects, so that the spleen and kidney are healthy and vigorous, and qi and blood are smooth. Clinical validation information shows that the Chinese medicine disclosed by the invention also has the effects of resisting and inhibiting bacteria, enhancing the organism immune capacity, improving vascular microcirculation and the like.

The invention provides a sustained-release injection or sustained-release implant containing antibacterial drugs. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from EVAc, polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.

Wind dispelling and cold expelling semen trichosanthis oil is prepared from the following raw materials in parts by weight: 250-260 parts of semen trichosanthis, 30-40 parts of flaxseed, 70-80 parts of zanthoxylum armatum, 50-60 parts of coconut shells, 60-100 parts of radix rehmanniae preparata, 30-40 parts of roasted sinapis seeds, 50-70 parts of antler glue, 20-30 parts of cortex cinnamomi, 20-30 parts of herba ephedrae, 20-30 parts of charcoal of ginger, 30-40 parts of fresh radix glycyrrhizae, and the like. During the preparation process, the zanthoxylum armatum with the efficacies of dispelling wind and expelling cold is added; the radix rehmanniae preparata nourishes yin and blood, replenishes essence, and benefits marrow; antler glue is matched for use to achieve the effects of reinforcing kidney to strengthen yang, and strengthening the muscles and bones; cold coagulation and humidity hysteresis cannot be eliminated without warming collaterals, so that the cortex cinnamomi and charcoal of ginger are added to warm yang, expel cold and promote blood circulation, so as to alleviate the symptoms; a small amount of the herba ephedrae is used for opening striae and interstitial space to expel cold coagulation of body surface; the sinapis seeds are used to eliminate phlegm, remove dampness, and promote qi and blood circulation, and can eliminate phlegm inside flesh and outside membrane; the fresh radix glycyrrhizae removes toxicity, and moderates the properties of all the medicinal materials; the semen trichosanthis oil can warm the middle energizer to dispel cold, and is suitable for being taken by people suffering from coagulation cold syndromes due to blood deficiency, including rheumatic ostealgia, bone tuberculosis, tuberculosis of peritoneum, chronic osteomyelitis, periostitis, chronic lymphadenitis, rheumatoid arthritis, thromboangiitis obliterans, deep abscess of muscles, and the like.

The invention provides a sustained-release injection or sustained-release implant containing antibiotics. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from poly(ethylene-co-vinylacetate) (EVAc), polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release the drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis and abscess.