7 results about "Chronic osteomyelitis" patented technology

This invention belongs to the field of traditional Chinese medicine external preparation technology, specifically providing a traditional Chinese medicine ointment for treating chronic osteomyelitis, bone tuberculosis, and persistent sinus tracts, as well as its preparation method. The traditional Chinese medicine ointment provided by this invention comprises 3-10 parts of *Achyranthes bidentata*, 5-15 parts of dried ginger, 0.3-1 part of red mercury sulfate, 20-50 parts of calcined gypsum, 4-12 parts of gecko, 5-15 parts of buffalo hide, and 40-100 parts of medicinal ointment base. This invention selects *Achyranthes bidentata*, red mercury sulfate, calcined gypsum, gecko, dried ginger, and buffalo hide as the main ingredients, achieving a combination of warming and cooling properties, and a tonifying and purging effect. It can effectively clear deep pus, necrotic tissue, and dead bone, while also warming and unblocking meridians, improving local blood circulation, promoting wound healing, and reducing the irritation of the medication.

The invention discloses a navigation system for preoperative design and intraoperative monitoring and treatment of chronic osteomyelitis, and relates to the field of medical instruments, the navigation system comprises a vertical arm, a wound surface auxiliary positioning disc is arranged on one side of the top end of the vertical arm, and a camera is arranged in the middle of the wound surface auxiliary positioning disc; the lower surface of the wound surface auxiliary positioning disc is provided with a plurality of wound surface auxiliary positioning lamps, the multiple wound surface auxiliary positioning lamps are evenly arranged around the camera, and each wound surface auxiliary positioning lamp emits a single-color light beam. According to the system, the wound range and debridement key points of a patient can be distinguished, marked and navigated on the basis of the camera, a doctor can perform surgical operation more accurately, the surgical time and trauma are reduced, in addition, multi-degree-of-freedom control operation is achieved through the mechanical manipulator and the clamping assembly, the steel plate clamping and fixing action of bones is achieved, and the working efficiency is improved. The steel plate can be tightly attached to the bone, the operation efficiency can be improved, and the workload of doctors is relieved.

The invention relates to the technical field of medical information, in particular to a chronic osteomyelitis prediction model training method, prediction method and device based on habitat imaging and radiomics, electronic equipment and a storage medium. Comprising the following steps: respectively training multiple machine learning algorithms by using a first sample set, a second sample set, a third sample set, a fourth sample set, a fifth sample set and a sixth sample set to obtain corresponding six types of training model sets; and respectively selecting the model with the best evaluation result from the six types of training model sets to form a chronic osteomyelitis prediction model group. According to the method, the internal heterogeneity of the focus can be deeply quantified and the internal heterogeneity and microenvironment characteristics of the focus can be captured on the basis of the inhabitation characteristics, the focus can be more accurately positioned when the boundary of the focus is fuzzy, a clearer focus excision boundary is provided for surgeons, scientific excision is further converted into accurate excision, unnecessary tissue damage is reduced, and the operation efficiency is improved. And the risk of postoperative recurrence and complications is reduced.

The invention relates to the technical field of medical information, in particular to a chronic osteomyelitis prediction model training method, prediction method and device based on radiomics, electronic equipment and a storage medium, and the method comprises the steps: obtaining a first sample set, a second sample set and a third sample set, carrying out the training of a plurality of machine learning algorithms, obtaining a corresponding original ROI training model set, a first external expansion ROI training model set and a second external expansion ROI training model set, respectively testing each training model set, and selecting a model with the best evaluation result as an original ROI prediction model, a first external expansion ROI prediction model and a second external expansion ROI prediction model. According to the method, effective chronic osteomyelitis debridement auxiliary decisions can be obtained during application by utilizing a step-by-step expansion strategy and algorithm optimization, and more comprehensive focus evaluation and clearer operation edge selection are provided for surgeons; accurate and effective auxiliary data support is provided for finding a relatively safe balance point between'thorough debridement 'and'minimization of bone injury'.

The invention discloses a nano sound-sensitive agent for treating and preventing chronic osteomyelitis and a preparation method thereof, and the preparation method comprises the following steps: step 1, dropwise adding a zinc acetate solution into a dimethylimidazole solution, fully reacting, and centrifugally washing to obtain ZIF-8; step 2, adding a manganese-containing compound into the ZIF-8 solution, fully reacting, and centrifugally washing to obtain Mn < 2 + >-doped ZIF-8 nanoparticles; and step 3, adding the Mn < 2 + >-doped ZIF-8 nanoparticles into a trehalose solution, fully stirring and mixing, and centrifugally washing to obtain the required sound-sensitive agent. The sonosensitizer obtained by the invention can gradually degrade and release Mn < 2 + > in an acidic microenvironment of an osteomyelitis infected part. The released Mn < 2 + > further enhances the sensitivity of cGAS to bacterial DNA, effectively activates an STING pathway in DCs, promotes maturation of the DCs, enhances the antigen presentation capability, and then promotes proliferation and differentiation of T cells and induces generation of memory B cells, thereby being beneficial to prevention of hidden survival and infection recurrence of bacteria.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a traditional Chinese medicine compound preparation with anti-infection and bone repair functions. The traditional Chinese medicine compound preparation is prepared from the following raw materials in parts by mass: 10 to 30 parts of flos lonicerae, 10 to 20 parts of flos chrysanthemi indici, 5 to 20 parts of herba taraxaci, 5 to 15 parts of radix astragali seu hedysari, 5 to 20 parts of cortex eucommiae, 1 to 10 parts of herba violae, 1 to 10 parts of radix semiaquilegiae, 1 to 5 parts of gelatin, 1 to 5 parts of collagen, 1 to 2 parts of trehalose, 1 to 3 parts of chitosan, 1 to 2 parts of emulsifier and 100 to 200 parts of soluble calcium salt aqueous solution. The traditional Chinese medicine compound preparation has the dual requirements of infection resistance and bone repair, meanwhile, the stability is remarkably improved through dosage form improvement, the preparation method is simple, and a potential traditional Chinese medicine compound preparation choice is provided for clinical treatment of chronic osteomyelitis.

The invention provides a medicine for treating diseases related to bacterial infection and application of the medicine, and particularly relates to the field of medicine. According to the invention, MRSA bacterial calcification can be induced in a targeted manner under the blood calcium ion level with physiological concentration, MRSA death is caused by inhibiting bacterial aerobic respiration and energy metabolism, and bacterial virulence and quorum sensing are inhibited. After in-vivo systemic injection of a mouse, the MRSA site can be efficiently targeted, MRSA calcification sterilization is induced, calcified bacteria can enhance inherent sterilization immunity of a host with a mononuclear macrophage system as a main part, macrophages are promoted to be polarized into an inflammatory macrophage state, the bacterial phagocytic ability and the inflammatory factor secretion ability of the host are enhanced, and the anti-inflammatory effect of the host is improved. Therefore, mouse chronic pulmonary infection and chronic osteomyelitis caused by MRSA are effectively treated, the survival rate of mouse pneumonia and osteomyelitis is remarkably improved, and the bone density of patients with osteomyelitis is improved. The invention has the potential to be developed into a novel non-antibiotic bactericidal drug for treating intractable pathogen infection such as drug-resistant bacteria and the like.