92 results about "Chronic osteomyelitis" patented technology

The invention relates to an anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt. The composite bone cement is prepared by mixing HACC, PMMA and bone cement monomers, wherein the mass ratio of the HACC and the PMMA is 15-30%. The invention also provides a preparation method and applications for the composite bone cement. The invention has the advantages that the PMMA of the composite HACC can replace the current frequently-used PMMA antibiotic bead chain, can be applied to bone defect filling, infection prevention, treatment of chronic osteomyelitis and centrum reinforcement of osteoporosis, achieves the antimicrobial activity similar to the antibiotic bone cement, simultaneously avoids the generation of antibiotic resistance, can be used for patients with resistance to antibiotics, and has larger clinical application values; and appropriate reduction of elastic modulus is also beneficial to reducing the non-uniform stress distribution of a cured centrum and an adjacent centrum section, thus relieving the early degeneration of adjacent intervertebral disk and fracture of adjacent centrums.

The present invention provides an anti-infection bone cement, which comprises magnesium-based metal particles, a bone cement matrix and a bone cement monomer, wherein a weight ratio of the magnesium-based metal particles to the bone cement matrix is (1-60):100, and the ratio of the volume of the bone cement monomer to the total mass of the magnesium-based metal particles and the bone cement matrix is (0.5-3 mL):(1-5 mg). According to the anti-infection bone cement of the present invention, the bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used PMMA antibiotic bead chain so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement is achieved while the generation of the antibiotic resistance is avoided; the anti-infection bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the anti-infection bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

The invention belongs to the field of the traditional Chinese medicine preparation, in particular to a traditional Chinese medicine combination for treating chronic osteomyelitis and a preparation method thereof. The traditional Chinese medicine combination is prepared by the following raw materials by weight proportion: 5-12 parts of saffron, 50-80 parts of gardenia, 80-95 parts of honeysuckle, 40-50 parts of frankincense, 30-40 parts of myrrh, 40-50 parts of radix astragali, 35-45 parts of ground beetle, 15-25 parts of leech, 28-36 parts of scorpion and 30-40 parts of liquorice. The invention has simple prescription, simple preparation method and convenient use; when the medicine is used for treatment, patients almost have no suffering and are willing to accept; the invention has realistic and reliable curative effect and low cost, can remarkably enhance the cure rate and recovery rate of chronic osteomyelitis and is worthy of clinical popularization. .

The invention discloses use of a reagent for detecting the expression level of a C19orf43 protein from a serum exosome as a marker for diagnosing osteosarcoma. The maker can realize reliable diagnosis, particularly realizes distinguishing of osteosarcoma, chronic pyogenic osteomyelitis, Ewing's sarcoma, metastatic tumor of bone and osteoarticular tuberculosis. Furthermore the invention provides aninstant detecting platform of the exosome protein for detecting the marker. The method has advantages of high efficiency, simple operation, low cost and high clinical auxiliary diagnosis value.

The present invention provides a bone infection preventing and treating composite bone cement, which comprises, by mass, 0.5-70 wt% of magnesium-based metal particles, 10-95 wt% of a calcium phosphate bone cement matrix, and 1-60 wt% of a curing liquid. According to the bone infection preventing and treating composite bone cement of the present invention, the calcium phosphate bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used antibiotic-loaded calcium phosphate bone cement matrix so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability is far higher than the antibacterial capability of the traditional bone cement and achieves the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement while the generation of the antibiotic resistance is avoided; the bone infection preventing and treating composite bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the composite bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

The invention provides ointment for treating acute and chronic osteomyelitis and a preparation method thereof. The ointment is prepared from the following components in parts by weight: 600-1000 parts of sesame oil, 60-100 parts of mulberry twig, 60-100 parts of willow twig, 60-100 parts of peach twig, 60-100 parts of elm twig, 60-100 parts of pagoda tree twig, 180-200 parts of minium, 100-120 parts of frankincense, 100-120 parts of myrrh, 30-60 parts of Chinese angelica, 30-60 parts of salvia miltiorrhiza, 30-60 parts of scutellaria baicalensis, 30-60 parts of cortex phellodendri and 30-60 parts of coptis chinensis. The ointment has the effects of promoting growth of renewal skin, activating blood circulation to remove stasis, clearing heat and diminishing swelling and the like, can be directly applied to an affected part, and has the advantages of quick response, safety and reliability, convenience in use and long storage time.

The invention provides a traditional Chinese medicine for treating heat-toxicity accumulation type chronic osteomyelitis and a preparation method thereof. The traditional Chinese medicine is prepared from orally-taking medicines and external medicines, wherein the orally-taking medicines comprise the following various bulk drugs: riparian greenbrier root and rhizome, bunge corydalis herb, kweiyang betony herb, japanese violet herb, bees, cordate houttuynia, rhododendron delavayi, sixangular dysosma rhizome, glabrousleaf pittosporum root, tonkin tinomiscium stem, caulis alsophilae, glabrous sarcandra herb; the external medicines comprise the following various bulk drugs: umbrellaleaf, adiantum capillus-veneris, garden balsam stem, purslane speedwell herb, laciniate kalanchoe herb, henbit, four-leaf clover, kamuning, Chinese fevervine herb and common rockvine herb. According to the traditional Chinese medicine, an internal use mode and an external use mode are combined, the traditional Chinese medicine has the functions of clearing away heat and toxic materials, promoting blood circulation and removing meridian obstruction, removing rotten scattered stasis and relieving swelling and pain, and has the exact curative effect in treatment of the heat-toxicity accumulation type chronic osteomyelitis and small side effects.

An implantative calcium sulfate-based local releasing system for treating chronic osteomyelitis and osteocarcinoma is proportionally prepared from calcium sulfate, polymer disperser, and medicine through mixing, adding physiologic soline, stirring, die pressing and vacuum drying.

The invention discloses an osteopathia rehabilitation pill for treating chronic osteomyelitis. The osteopathia rehabilitation pill is mainly prepared from the following raw medicinal materials in parts by weight: 150 to 170 parts of astragalus membranaceus, 95 to 115 parts of angelica sinensis, 45 to 60 parts of rhizoma atractylodis, 45 to 60 parts of poria cocos, 75 to 95 parts of semen coicis, 100 to 120 parts of honeysuckle, 105 to 115 parts of codonopsis pilosula, 45 to 60 parts of radix paeoniae alba, 80 to 90 parts of dandelion, 45 to 60 parts of pericarpium citri reticulatae, 25 to 40 parts of licorice root, 50 to 65 parts of wolfberry fruit and 50 to 65 parts of prepared radix rehmanniae. The osteopathia rehabilitation pill which is used for treating the chronic osteomyelitis is short in treatment time, free of side effect and obvious in treatment effect and has the total effective rate being above 90%.

The invention discloses a medicine for treating the chronic osteomyelitis, belonging to the field of traditional Chinese medicines. The medicine comprises the effective components in parts by weight: 40-45 parts of asparagus cochinchinensis, 40-60 parts of rehmanniae vaporata, 40-55 parts of rhizoma anemarrhenae, 40-55 parts of small purple flowersherba violae, 40-50 parts of parasitic loranthus, 40-50 parts of dry radix puerariae, 35-55 parts of rhizoma atractylodis, 35-50 parts of barbary wolfberry fruit, 30-50 parts of pawpaw, 25-45 parts of myrrh, 25-45 parts of golden cypress, 25-45 parts of divaricate saposhnikovia root, 25-40 parts of radix angelicae, 20-40 parts of cuttle bone, 15-35 parts of lumbricus, 15-35 parts of scutellaria baicalensis, 15-30 parts of endothelium corneum gigeriae galli, 10-15 parts of borneol, 5-10 parts of cortex cinnamomi and 5-10 parts of corn cervi pantotrichum. The medicine disclosed by the invention has the advantages that traditional Chinese medicines are adopted, the compatibility of material selection is excellent, all the components dependences are prepared according to the properties, the function of treating both principal and secondary aspectmanifestation and root cause of disease is achieved, and the effects of improving the blood circulation, regulating vital energy, dispersing blood stasis and toxicity; the absorbing effect is good, the treating effect is obvious, the safe and reliable effects are achieved, no toxic and side effects and clinical adverse reaction are caused; and by clinical verification, the treating effect for chronic osteomyelitis is excellent.

The invention relates to the field of traditional Chinese medicine, and discloses a compound coptis chinensis liquid which is prepared by using coptis chinensis, scutellaria baicalensis, golden cypress, jasmine, garden burnet, rheum officinale, astragalus mongholicus and borneol as raw materials and boiling in water and extracting. The compound coptis chinensis liquid has a good effect in treating chronic osteomyelitis and acute soft tissue injury, reduces the production cost, is simple and convenient to use, wide in application range and convenient to store and popularize.

The invention provides a traditional Chinese medicine for treating body-resistance-weak and pathogen-strong type chronic osteomyelitis, and a preparation method thereof. The traditional Chinese medicine comprises a medicine for oral administration and a medicine for external use, wherein the medicine for oral administration comprises the following medicinal materials: radix achyranthis bidentatae, radix acanthopanacis semticosi, stellaria yunnanensis, codonopsis convolvulacea, ventilago leiocarpa benth, corallodiscus flabellatus, pyrola, sargentgloryvine stem, lovage, evening primrose, rhododendron delavayi, elderberry and rhizoma dioscoreae hypoglaucae; the medicine for external use comprises the following medicinal materials: pararuellia delavayana, cupparis spinosa, common andrographis herb, helwingia root, radix rubiae, siberian walking fern, paniculate spotflower herb, cryptolepis buchananii, fir club moss, radermachera sinica and cortex kadsurae radicis. The traditional Chinese medicine provided by the invention has the effects of combining oral administration and external use, strengthening the body resistance, eliminating pathogen, benefiting qi, nourishing blood, removing toxicity, promoting granulation, activating blood, dissolving stasis and relieving swelling and pains, has an extract curative effect for the body-resistance-weak and pathogen-strong type chronic osteomyelitis, and has slight toxic and side effects.

The invention provides a sustained-release injection or sustained-release implant containing lincomycin antibiotic. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from poly(ethylene-co-vinylacetate) (EVAc), polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.

The invention discloses a Chinese medicinal fumigation-washing lotion for treating chronic osteomyelitis. The chronic osteomyelitis is also known as chronic suppurative osteomyelitis, and is called as suppurative osteomyelitis by the traditional Chinese medicine. The disease is mainly caused by the Qi loss, heat toxin for harming the surface, evil, poison evil invagination, evil in the bones and muscles. Therefore, sorbaria kirilowii, securidaca inappendiculata hassk, berberis dasystachya maxim, souliea vaginata, meadowrue root and rhizome, nauclea offcinalis, entireleaf neoalsomitra, fructus forsythia, patrinia, albizia chinensis root, raphiolepis indica, beautyberry leaf and licorice are soaked into water and boiled into the fumigation-washing lotion. The lotion is used for fuming and washing patients, the total effective rate is 97.5% shown by clinical trials in the hospital and relapse is eliminated during one year of follow-up visit.

The invention discloses an external Chinese medicinal ointment for treating chronic osteomyelitis. The chronic osteomyelitis belongs to the range of the traditional Chinese medicine suppurative osteomyelitis, and the suppurative osteomyelitis is mostly caused by the process of external injury fracture, Qi-stagnation and blood stasis, lasting stasis, heat, heated body fluid, fester. Therefore, plyas mucosus root, radix ampelopsis, bovista, broomjutre sida herb, cardiospermum with small fruit, beautyberry leaf, catecholamine, pearl and hydrargyrum oxydatum crudum with the function of promoting blood circulation and removing blood stasis, clearing away heat and toxic materials, building the body and removing pus, removing necrotic tissue and promoting granulation are prepared into powder in the manufacturing laboratory of the hospital, the powder is prepared into the ointment via the sesame oil, and then the ointment is infiltrated by the sterile gauze strip for preparing the traditional Chinese medicine gauze strip for external use on the surface of the wound or internal use for the wound antrum. After clinical trials, the total effective rate is 97.9% and relapse is eliminated.

The invention discloses an external medicinal composition for treating chronic osteomyelitis. The external medicinal composition for treating the chronic osteomyelitis is prepared from active ingredients and a pharmaceutic adjuvant, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 21-30 parts of Chinese violet, 15-26 parts of pagoda tree pod, 6-12 parts of szechwan lovage rhizome, 6-12 parts of stephania terandra and 18-30 parts of coptis chinensis. After the external medicinal composition disclosed by the invention is used for treating the chronic osteomyelitis, recovery of a bone structure of a sicken limb is in a progressive course, and combined action of the external medicinal composition for treating the chronic osteomyelitis for controlling infection and promoting bone regeneration is obviously better than pure anti-infection effect of antibiotic.

The invention discloses a medicine for treating chronic osteomyelitis and a preparation method of the medicine, and belongs to the field of traditional Chinese medicines. Raw materials of effective components of the medicine comprise Japanese polygala, Japanese violet herb or root, humulus japonicus, cantonese ampelopsis, aeginetia indica, radix isatidis, eucommia ulmoides, araliaceae acanthopanax trifoliatus, abelmosk, cuneate lespedeza herb with root, wallich pepper stem and leaf, lamium amplexicaule, licorice, obscured homalomena rhizome, ambrosia artemisiifolia and elk's horn. The medicine is appropriate in compatibility, is prepared according to the property of the medicine to achieve the functions of treating both symptoms and root causes, promoting blood circulation, regulating vital energy, dispersing blood stasis and removing toxicity, is good in absorption effect, remarkable in treatment effect, safe, reliable and free from toxic and side effects and clinical adverse reaction, has the extremely good treatment effect on the chronic osteomyelitis, is capable of obviously improving the immunity of a human body, and can be widely applied to clinical treatment of the chronic osteomyelitis.

The invention discloses a traditional Chinese medicine formula for treating osteomyelitis. The traditional Chinese medicine formula consists of the following components: liquorice, radix clematidis, poria cocos, ligusticum wallichii, golden cypress, root of common peony, rhizoma sparganii, curcuma zedoary, calamine, manyleaf paris rhizome and dandelion. With the adoption of the traditional Chinese medicine, the selected materials are excellent in compatibility, the drug effect is achieved, the effects of treating both symptoms and root causes, nourishing liver and kidney, regulating qi and blood, dispersing blood stasis and detoxifying, repairing bones and generating new tissues, removing the necrotic tissue and promoting granulation are achieved, and the traditional Chinese medicine formula has the effects of enhancing disease resistance and repair capacities of the organism aiming at weakened body resistance while prevailing pathogenic factors by using methods for strengthening the body resistance to eliminate pathogenic factors and treating both symptoms and root causes, has strong antibacterial and bone and soft tissue regeneration promotion effects on non-sterile osteonecrosis and has an excellent treatment effect on acute or chronic osteomyelitis.

An application of shrubby dendrotrophe twigs is preparing the medicines for treating allergic dermatitis, urticaria, bone tuberculosis, lymph tuberculosis, skin tuberculosis, chronic osteomyelitis, etc is disclosed.

The invention discloses a sustained release injection containing mezlocillin, which consists of sustained release microspheres and menstruum, wherein, the sustained release microspheres contain sustained release excipient and penicillin antibiotics, the menstruum is special menstruum containing suspending agents such as sodium carboxymethyl cellulose and so on, and the viscosity is between 100 and 3000cp (at the temperature of between 20 and 30 DEG C); the sustained release excipient is selected from EVAc, polifeprosan, PLA, PLGA, decanedioic acid copolymers, albumin glue, gelatin and so on; and the sustained release microspheres can also be prepared into sustained release implant. The sustained release implant and the sustained release injection are locally placed or injected on a bacteria focus, which can slowly release medicine at a local lesion for 5 to 30 days and apparently decrease the systemic toxicity of the medicine when the effective medicine concentration of the local lesion is effectively obtained and maintained. The sustained release injection has a remarkable and unique treatment effect on infections caused by staphylococcus, streptococcus, peptostreptococcus, acne propionate bacillus, enterobacter, tubercle bacillus, gonococcus or meningococcus and so on, particularly on local lesions such as chronic osteomyelitis, severe bedsore, refractory skin ulcer, diabetic foot and femoral head necrosis of diabetes, and various abscesses and so on.

The invention discloses a traditional Chinese medicinal external application agent for treating chronic osteomyelitis. Chronic osteomyelitis has many causes, such as physique weakness, intense internal heat, kidney essence deficiency, cold dampness evil and physique weakness, deep invasion Fu junction, chronic depression transforming heat, damp heat evil stagnation in meridians and qi blood, and suppuration injury to bone. Botrychium virginianum, Root of Tubeflower Duchmans pipe, Leaf of Pubescent Holly, Arabis pendula L., glomeris, Leaf of Ivy tree, Plumbago auriculata, Rhaphidophora decursiva, laevigate elatostema herb, Maesa perlarius (Lour.)Merr. and root of bengal clockvine are selected and are processed through a traditional making technology to prepare an ointment. Clinic tests of the ointment show that the total effective rate is 85.4% and is obvious better than that of a control group (68.7%), and the clinic effect is good.

The invention discloses external-use paste for treating chronic osteomyelitis. The external-use paste is mainly prepared from, by mass, the following raw material medicine of 12-18 parts of dandelions, six to ten parts of trumpet shells, eight parts to 12 parts of pyracantha fortuneana roots, 10-16 parts of pholidota chinensis lindl, nine parts to 13 parts of umbellate elatostema, seven parts to 15 parts of clematis, three to six parts of toxic nightshade, seven parts to 11 parts of simple glorybower roots, nine parts to 16 parts of bulbiferous laportea roots, eight parts to 12 parts of Japanese polygala, 10-14 parts of illigera cordata, nine parts to 15 parts of fiddleleaf fig root leaves, seven parts to 13 parts of herba erigerontis, 10-15 parts of angelica citriodora hance and nine parts to 17 parts of root-bark of spinystem aralia. Traditional Chinese medicine materials are selected, the external-use paste is mild, has no stimulation and has no toxic or side effect, the component fully conforms to traditional Chinese medicine rules, and the effects of clearing away heat and toxic materials, invigorating the circulation of blood and eliminating stasis, removing slough and promoting growth of tissue regeneration and the like are achieved. The medicine of the external-use paste can be guided to illness stations, inflammation resolution is promoted, an ulcer surface is promoted to heal, the treatment effect is good, and the cure rate is high.

The invention provides a traditional Chinese medicine formula for treating acute / chronic osteomyelitis. The formula is composed of the following raw materials: coptis, radix astragali, licorice, viola japonica, cornu cervi degelatinatum, honeysuckle flower, poria cocos, live earthworm, and semen cuscutae. The invention further provides a preparation method and application method of the traditional Chinese medicine formula. On the basis of traditional Chinese medicine theory and clinical experience, the herbals and weight ratio are determined, the synergetic effect or resistance effect among the components is utilized to improve the curative effect, and the traditional Chinese medicine formula has the advantages of prominent curative effect, short treatment course, low cost, and no side or toxic effect, and can treat both the root and symptoms of osteomyelitis. The traditional Chinese medicine formula has the functions of moving qi and promoting blood circulation, thus can supply enough blood to bones and soft tissues; furthermore, has the functions of activating blood circulation to remove blood stasis, activating collaterals, and freeing veins, and thus can free the collaterals around bones and promote the blood circulation, so the toxicity in the affected parts is reduced, the immunity is enhanced, and osteomyelitis can be radically cured.

The invention discloses a Chinese medicine for preventing and treating chronic osteomyelitis and a preparation method thereof, and belongs to the field of Chinese medicines. The medicine disclosed by the invention comprises the following effective ingredients of raw materials in parts by weight: 60 parts of dandelion, 60 parts of angelica sinensis, 53 parts of radix paeoniae alba, 52 parts of siam psychotria herb, 48 parts of honeysuckle, 45 parts of astragalus membranaceus, 45 parts of rehmanniae vaporata, 40 parts of parasitic loranthus, 40 parts of liquorice, 35 parts of tuckahoe, 32 parts of hematoxylon, 25 parts of huangcipi (Chinese character), 25 parts of rhizoma drynariae, 24 parts of myrrh, 20 parts of radix angelicae, 18 parts of spina gleditsiae, 14 parts of endothelium corneum gigeriae galli, 13 parts of swimming bladder, 15 parts of cicada slough, 12 parts of cartialgenous, 9 parts of scorpio, 7 parts of cinnamon, 4.5 parts of sting worm and 5 parts of cuttlebone. The Chinese medicine selects the medicinal materials according to the principles of monarch, minister, assistant and guide, and is elaborately prepared, and medicaments in the full formula have the effects of nourishing and purging, treating both symptoms and root causes, promoting and nourishing qi and blood, boosting essence and filling marrow, tonifying spleen and kidney, strengthening body resistance and eliminating evil, and promoting tissue regeneration, and have significant curative effects, so that the spleen and kidney are healthy and vigorous, and qi and blood are smooth. Clinical validation information shows that the Chinese medicine disclosed by the invention also has the effects of resisting and inhibiting bacteria, enhancing the organism immune capacity, improving vascular microcirculation and the like.

The invention discloses a traditional Chinese medicine preparation for treating chronic osteomyelitis as well as a preparation method and application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 33 to 40 parts of Indian abution roots, 3 to 9 parts of silkworm cocoons, 5 to 15 parts of pomegranate flowers and 18 to 26 parts of houttuynia cordata. The traditional Chinese medicine preparation is prepared by the following steps: crushing the Indian abution roots and the silkworm cocoons and adding absolute ethyl alcohol to treat; adding water, carrying out freezing and melting treatment and drying to obtain a mixture A; adding the water into the houttuynia cordata and boiling with strong fire; decocting with small fire and filtering to obtain houttuynia cordata liquid; mixing the pomegranate flowers and the houttuynia cordata liquid and adding the mixture A; drying to obtain the traditional Chinese medicine preparation for treating the chronic osteomyelitis. The traditional Chinese medicine preparation for treating the chronic osteomyelitis has the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, detoxifying and removing pus, removing the necrotic tissue and promoting granulation, and eliminating swelling and alleviating pain; when the traditional Chinese medicine preparation is used for treating the chronic osteomyelitis, the absorption effect is good, and the curative effect is remarkable; the traditional Chinese medicine preparation is safe and reliable and has no toxic side effects, and the chronic osteomyelitis is not relapsed after being cured. The preparation process is simple and easy to operate and is low in operation cost, so that the preparation process is suitable for industrial production.

The invention provides a sustained-release injection or sustained-release implant containing antibacterial drugs. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from EVAc, polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.

The present invention discloses one kind of medicine composition for treating chronic osteomyelitis. The medicine composition is prepared with cantharis, raw Sichuan aconite root, wild aconite root, pangolin scale, frankincense and other eight kinds of Chinese medicinal materials. The medicine composition has the functions of warming Yang to dispel cold, promoting blood circulation to disperse blood clots, reducing swelling, relieving pain, removing toxic substance and promoting granulation, and possesses obvious curative effect on chronic osteomyelitis.

Wind dispelling and cold expelling semen trichosanthis oil is prepared from the following raw materials in parts by weight: 250-260 parts of semen trichosanthis, 30-40 parts of flaxseed, 70-80 parts of zanthoxylum armatum, 50-60 parts of coconut shells, 60-100 parts of radix rehmanniae preparata, 30-40 parts of roasted sinapis seeds, 50-70 parts of antler glue, 20-30 parts of cortex cinnamomi, 20-30 parts of herba ephedrae, 20-30 parts of charcoal of ginger, 30-40 parts of fresh radix glycyrrhizae, and the like. During the preparation process, the zanthoxylum armatum with the efficacies of dispelling wind and expelling cold is added; the radix rehmanniae preparata nourishes yin and blood, replenishes essence, and benefits marrow; antler glue is matched for use to achieve the effects of reinforcing kidney to strengthen yang, and strengthening the muscles and bones; cold coagulation and humidity hysteresis cannot be eliminated without warming collaterals, so that the cortex cinnamomi and charcoal of ginger are added to warm yang, expel cold and promote blood circulation, so as to alleviate the symptoms; a small amount of the herba ephedrae is used for opening striae and interstitial space to expel cold coagulation of body surface; the sinapis seeds are used to eliminate phlegm, remove dampness, and promote qi and blood circulation, and can eliminate phlegm inside flesh and outside membrane; the fresh radix glycyrrhizae removes toxicity, and moderates the properties of all the medicinal materials; the semen trichosanthis oil can warm the middle energizer to dispel cold, and is suitable for being taken by people suffering from coagulation cold syndromes due to blood deficiency, including rheumatic ostealgia, bone tuberculosis, tuberculosis of peritoneum, chronic osteomyelitis, periostitis, chronic lymphadenitis, rheumatoid arthritis, thromboangiitis obliterans, deep abscess of muscles, and the like.

The invention provides a sustained-release injection or sustained-release implant containing antibiotics. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from poly(ethylene-co-vinylacetate) (EVAc), polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release the drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis and abscess.