The invention relates to plaster for treatment of furunculosis gall and a production process thereof. The plaster is characterized by being prepared according to the following formula: 200-300 parts of sesame oil, 100-150 parts of minium, 10-20 parts of sangusis draconis, 8-12 parts of raw semen strychni, 3-7 parts of myrrh, 3-7 parts of frankincense, 3-7 parts of scorpion, 3-7 parts of semen momordicae, 3-7 parts of borneol, 3-6 parts of centipede and 1-3 parts of moschus. The plaster has the effects of clearing away heat and toxic substances, promoting blood circulation to remove blood stasis, dispersing swelling to remove stasis, relieving pains, diminishing inflammation, sterilizing, dispelling wind and eliminating dampness, removing rot muscles, eliminating swelling and empyema and promoting cell recovery and growth, has special effects on treatment of noisome sore, pyogenic infections, anonymous gall and ulcer, and has satisfactory effects on treatment of rheumatic pains, rheumatism, scapulohumeral periarthritis, arthritis, joint rigidness, lumbocrural pains, bone tuberculosis, slipped discs, numbness of sinews and bones, traumatic injury and the like. The formula is scientific and reasonable, the production process is unique, both principal and secondary aspects of diseases can be treated, the plaster can be applied easily, few side effects can be caused, and significant economic and social benefits can be achieved. Moreover, the production process is simple and inexpensive and is suitable for production in preparation departments of all levels of hospitals and pharmaceutical factories of traditional Chinese drugs.