362 results about "Analgesic effect" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention relates to the field of biological medicine, in particular to a compound and a preparation method and application thereof. Particularly, the invention relates to a compound shown in a formula (I) or pharmaceutically acceptable salt, stereoisomer, solvate, isotope labeled compound or polymorphic substance thereof, a preparation method thereof, a pharmaceutical composition containing the compound and application thereof, the compound can be used as a sodion channel inhibitor, has an analgesic effect, and can be used for preparing a sodion channel inhibitor. The compounds of the present application also have a variety of excellent properties. # imgabs0 #

The invention discloses a self-adaptive control method of an analgesia infusion system based on multi-modal feedback, and relates to the field of analgesia infusion automation control, and the method comprises the steps: inputting a feature vector into a multi-modal fusion decision-making layer, and calculating a comprehensive pain index PI by adopting a confidence-weighted self-adaptive fusion algorithm; taking the comprehensive pain index PI, the drug cumulant and the physiological stability index as state input, and inputting the state input into a self-adaptive controller based on reinforcement learning; the adaptive controller outputs a basic infusion rate adjustment amount, a pulse dose adjustment amount, and a locking time adjustment amount. According to the invention, through multi-source signal acquisition and confidence coefficient weighted adaptive fusion, the accuracy and robustness of pain assessment are improved; the hierarchical reinforcement learning controller realizes personalized dose optimization on the premise of safety priority, and gives consideration to both analgesic effect and physiological stability; and the safety monitoring module is combined with multi-modal cross validation and pharmacokinetic prediction, so that the safety risk is effectively reduced.

The invention discloses an application of a CYP3A4 * 1G gene in preparation of a product for evaluating the postoperative analgesic effect and dosage prediction of sufentanil compounded with butorenol. According to the invention, the gene polymorphism of CYP3A4 * 1G is found to be one of genetic factors causing sufentanil compounded butornori postoperative analgesic effect and dosage use difference individualized difference for the first time, and anesthetists can determine the dosage of analgesic drugs for postoperative patients according to genetic characteristic difference, so that the satisfaction degree of anesthesia and postoperative analgesia of the patients is improved; therefore, the CYP3A4 * 1G gene can be used as a marker for evaluating the postoperative analgesic effect and dosage use of sufentanil compounded with butoenorphan, and detection is carried out through related genes of postoperative analgesic medication of a patient and CYP3A4 * 1G genotyping, so that guidance can be provided for the postoperative analgesic medication dosage of the patient.

The invention discloses a pharmaceutical composition for preventing and / or treating pain and application thereof.The pharmaceutical composition contains a Sigma-1 receptor antagonist and a histamine H3 receptor antagonist / inverse agonist and has a synergistic analgesic effect on various pains, the curative effect of the pharmaceutical composition is remarkably superior to that of a single drug, the use dosage of the single drug can be reduced, and therefore the side effect of single drug dosage dependence is reduced; good application prospects are realized.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a pharmaceutical use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has high-efficiency sedative, hypnotic and / or anesthetic effects, can control status epilepticus, and also has an analgesic effect, providing a new choice for clinical preparation of a drug having the analgesic effect, a drug having the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having both the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus and also having the analgesic effect.

The invention provides an intraoperative nursing anesthesia analgesia effect evaluation method and system based on data analysis. The method comprises the following steps: acquiring anesthesia information, adverse factors and post-anesthesia physiological indexes of a patient, converting the physiological indexes into relative values, distributing weights, and calculating a weighted sum; meanwhile, an adjustment coefficient is calculated according to the total number and existence number of adverse factors. And constructing an analgesic effect comprehensive evaluation model in combination with the weighted sum and the adjustment coefficient. And inputting the physiological indexes and the adverse factors of the patient to the model, calculating an analgesic effect evaluation score, and associating the score with the anesthesia information. According to the method, various factors in the anesthesia analgesia process are comprehensively considered, the physiological state of a patient is reflected, the influence of adverse factors is considered, and a comprehensive and accurate evaluation result is provided.

This invention belongs to the field of biomedical technology and discloses a method for targeting GABA. A The receptor-dependent cyclic peptide analgesic DZ2 has the following amino acid sequence: Cys-Asn-Thr-Glu-Arg-Pro-Gly-Met-Leu-Asp-Phe-Lys-Gly-Lys-Ala-Lys-Trp-Asp-Ala-Trp-Cys, where the N-terminal Cys and C-terminal Cys are cyclically linked by a disulfide bond, and the molecular weight is 2454.81 g / mol. This cyclic peptide can be obtained through classic Fmoc-solid-phase synthesis, using GABA... A Receptor-targeting drugs play an important role in drug development. The compounds provided in this invention can activate GABA. A The receptor generates a GABA-like inward current. Furthermore, DZ2 exhibits excellent analgesic effects in a mouse pain model, providing a potential alternative for GABA-based analgesics. A This provides new ideas and theoretical basis for the development of receptor-based analgesics.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has efficient sedative, hypnotic and / or anesthetic effects, can control the status epilepticus, further has an analgesic effect, and provides a new option for clinically preparing a drug having an analgesic effect, a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus, and a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus and also having the analgesic effect.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The invention discloses a trigeminal neuralgia treatment method, and relates to the technical field of trigeminal neuralgia treatment. The direct effect of the M2 on the proinflammatory and pain induction characteristics of the Schwann cells can play an important role in the multi-aspect analgesic effect of the M2; the microenvironment around nerves can be changed by increasing m < 2 > m macrophages after SHED-CM, so that NP is cured; immunohistochemical analysis shows that the number of p near-end side CD206 + F4 / 80 + macrophages of qualified thiocyanate is remarkably increased through sheet-CM treatment, however, TNF-alpha + S100beta + proinflammatory Schwann cells and TNF-alpha + F4 / 80 + M1 macrophages are remarkably reduced after sheet-CM treatment.

The invention belongs to the technical field of biological medicines, and particularly relates to a microneedle of a drug with a short half-life period as well as a preparation method and application of the microneedle. The bipolar controllable release microneedle is provided for drugs with short half-life periods, long-acting percutaneous minimally invasive drug delivery is achieved, the convenience and comfort of a patient in drug use are greatly improved, controllable plasma concentration maintaining time can be achieved by adjusting the proportion of the first-stage release phase and the second-stage release phase, and the personalized analgesic drug delivery requirement is met. Besides, by taking an opioid analgesic administration strategy as an entry point, the precise controllable two-stage release microneedle of the biphasic matrix carried medicine is innovatively provided, a new dosage form is developed for the opioid analgesic medicine, and compared with an existing intravenous injection administration mode, the analgesic time can be prolonged by 24 times, and the analgesic effect of the medicine is greatly improved.

According to the intelligent green light phototherapy glasses and the intelligent adaptation method thereof, a narrow-band green light LED light source with the central wavelength being 530 + / -5 nm is adopted, and individualized pain management is achieved in combination with heart rate variability, electrodermal response and pupil dynamic monitoring. A multi-source sensor and a micro control panel are arranged in the glasses, physiological data are collected in real time, the illumination intensity, frequency and irradiation mode are dynamically adjusted through an artificial intelligence algorithm, and a closed-loop phototherapy control system is constructed. The device supports Bluetooth / Wi-Fi connection, interacts with a mobile terminal APP, and realizes data recording, curative effect evaluation and remote monitoring. The system has multiple safety mechanisms such as constant-current driving, temperature feedback, over-illumination protection and posture detection, and long-term wearing safety is ensured. Through the regulation effect of green light on pain neural pathways, a safe, portable and intelligent chronic pain non-drug treatment means is provided under the condition that daily activities are not interfered, and high compliance and a remarkable analgesic effect are achieved.

The invention relates to the technical field of medical instruments, in particular to a multi-channel analgesia pump with remote monitoring and control functions, which comprises a disposable multi-channel analgesia pump and a non-disposable multi-channel analgesia pump, each of the disposable multi-channel analgesia pump and the non-disposable multi-channel analgesia pump comprises a multi-channel analgesia pump main body, a microfluidic liquid medicine delivery system, a multi-channel liquid medicine injection system, a wireless communication module and a remote control terminal. The disposable multi-channel analgesia pump or the non-disposable multi-channel analgesia pump can be selected according to the actual condition of a patient, and the flexibility and the practicability are high; by arranging the micro-fluidic liquid medicine delivery system, accurate release of liquid medicine doses in different channel liquid medicine injection units can be ensured, cross contamination of liquid medicine in the channel liquid medicine injection units is avoided, the analgesic effect is effectively improved, potential safety hazards caused by mixed use of the liquid medicine or inaccurate release of the liquid medicine are reduced, and the analgesic effect is improved. The safety and the effect of clinical treatment are improved.

The invention belongs to the technical field of sterile hydrogel patches, and particularly relates to a high-adhesion sterile hydrogel patch and a preparation method thereof. According to the preparation method of the high-adhesion sterile hydrogel patch, the high-adhesion sterile hydrogel patch is of a three-layer structure, the middle is a gel layer, the upper layer is a PE type release film, and the lower layer is a PE plastic sheet. According to the high-adhesion sterile hydrogel patch and the preparation method thereof, the formula of the high-adhesion sterile hydrogel patch is adjusted, a double-crosslinking system is utilized, the strength and toughness of hydrogel are guaranteed, meanwhile, the high-adhesion sterile hydrogel patch has high viscosity, low water loss rate and low swelling performance, the product can be repeatedly washed and worn, and in addition, the application range of the high-adhesion sterile hydrogel patch is widened. The cold compress analgesic effect is good; the invention further provides a preparation method, the preparation process is simple, and the whole process is non-toxic and harmless.

The invention relates to lidocaine multivesicular liposome as well as a preparation method and application thereof, belongs to the field of medicines, and solves at least one of the problems of higher toxicity, insufficient safety, short action time, limited clinical application range, higher cost and the like of the existing postoperative analgesic medicine. The lidocaine multi-vesicular liposome is prepared from lidocaine and a lipid, wherein the lidocaine and the lipid are added into the lidocaine multi-vesicular liposome; the lipid comprises amphiphilic lipid, negatively charged phospholipid, neutral lipid and cholesterol. The lidocaine multi-vesicular liposome prepared by the preparation method is high in safety, solves the problems of systemic toxicity, neurotoxicity, cardiotoxicity and the like of the existing postoperative analgesic drugs, has the characteristics of long-acting slow release, remarkable analgesic effect and wide clinical application range, and is suitable for clinical application. And a new solution is provided for effectively relieving postoperative pain.

The invention provides a composition with an analgesic effect. The composition is an external medicament prepared from the following raw material medicines in parts by weight: 10-16 parts of teasel root, 2-4 parts of dragon's blood, 8-12 parts of safflower, 9-15 parts of myrrh, 9-15 parts of ligusticum wallichii, 9-15 parts of notopterygium root, 8-12 parts of clove, 8-12 parts of beautiful sweetgum fruit, 0.6-1 part of pepper, 2-4 parts of lucid ganoderma, 0.4-0.8 part of capsaicin and 0.08-0.12 part of musk. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition is precise and appropriate in raw material formula compatibility, is used for treating pain, is clear and controllable in medicine effect, and provides a new choice for clinic.

The invention discloses a small molecular twin drug compound with a synergistic analgesic effect and a pharmaceutical composition, a preparation method and application thereof. The twin drug molecule is formed by connecting a drug A and a drug B through a covalent bond, the drug A is nefopam, and the drug B is gamma-aminobutyric acid (GABA) and analogues thereof and comprises gabapentin, pregabalin, GABA, melogabalin and crigabalin. The analgesic effect of the composition is superior to that of combined administration and single administration, and the composition can obviously improve various acute and chronic inflammation pains and can relieve paclitaxel-induced peripheral neuralgia; the anti-inflammatory activity is higher than that of combined use and single drug, so that the compound has the potential of treating pain, inflammation and inflammatory pain related diseases; the interaction among the medicines can be effectively reduced, and the medication compliance of a patient is improved.

The invention discloses substituted phenol derivatives and application thereof, and relates to the field of medicinal chemistry. The substituted phenol derivative is a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect, can control the state of epilepsy, and is good in safety during use. Therefore, the derivative has wide application prospects in preparation of drugs which have sedative, hypnotic and / or anesthetic effects and analgesic effects and can control the epileptic status. The invention provides a new choice for clinically preparing medicines which have the effects of easing pain, calming, hypnotizing and / or anesthetizing, controlling the epileptic status and the like. # imgabs0 #

A drug composition having the structure of formula I for the treatment of pain is provided. The drug can be given to an animal via oral, transdermal, rectal, intravenous, subcutaneous, sublingual or intraperitoneal administration, etc., thereby exerting an analgesic effect. The active components of the drug are convenient to prepare and easy to identify, and are structurally different from those of all other existing analgesic drugs, thus forming a novel class of effective analgesic compounds.

The invention provides a traditional Chinese medicine composition with anti-inflammatory and analgesic effects as well as a preparation method, application and a medicine thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 30-55 parts of pseudo-ginseng, 26-40 parts of notopterygium root, 15-35 parts of safflower, 15-35 parts of berba aristolochiae mollissimae, 20-40 parts of liquorice, 10-20 parts of acanthopanax and 10-30 parts of dandelion. Performing reflux extraction on the pseudo-ginseng, the notopterygium root, the safflower and the dandelion by using an ethanol solution to obtain an ethanol extracting solution and medicine residues; mixing the medicine residues, berba aristolochiae mollissimae, liquorice and acanthopanax, decocting with water, and then carrying out microwave treatment to obtain a water extracting solution; combining the ethanol extracting solution and the water extracting solution, and drying to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has synergistic effects of diminishing inflammation, easing pain and diminishing swelling; when the compound is applied to medicine preparation, the obtained medicine can remarkably reduce the pain degree and the osteoarthritis index and improve the joint motion range.

The invention discloses a compound and application thereof, and belongs to the technical field of medicinal chemistry. The structure of the compound is shown as a formula I. In the formula I, A ring is selected from C6-C12 aryl or C5-C6 cycloalkyl; r1 and R2 are independently selected from one or more of hydrogen, C1-C10 straight chain or branched chain alkyl, C3-C6 naphthenic base, C1-C10 alkoxy, substituted C1-C10 straight chain or branched chain alkyl, substituted C3-C6 naphthenic base, substituted C1-C10 alkoxy, amino, halogen, nitrile group and nitryl; m and n respectively represent the numbers of R1 and R2, m + n = 5, and m > = 1; l is selected from a thioformamido group, a formamido group, a sulfonyl group, a sulfonamido group, a sulfonylurea group, an ester group or a carbonyl group. The compound is unique and novel in structure, and has relatively strong inhibitory activity and excellent analgesic effect as a TRPV1 inhibitor. # imgabs0 #

The present invention relates to the technical field of plant compositions, and in particular to a plant anti-allergic, antipruritic and analgesic composition and its application. The present application discloses a plant anti-allergic, antipruritic and analgesic composition, which comprises the following raw materials by weight percentage: gentiana cyanus extract: 0.5%-5%, kava root extract: 1%-10%, prickly pear cactus leaf extract: 0.5%-5%, Centella asiatica extract: 1%-10%, and the balance is water. The present application provides a plant anti-allergic, antipruritic and analgesic composition, which achieves the effects of anti-inflammatory, anti-allergic, antipruritic and analgesic by inhibiting NO generation, inhibiting histamine pathways and inhibiting TRPV1 ion channels.

The invention discloses an application of robiniaflavin in preparation of a COX-2 selective inhibitor. The robiniaflavin can specifically inhibit the expression of COX-2 and reduce the expression of iNOS, COX-2 and TNF-alpha in an inflammation model. The robiniatin has remarkable anti-inflammatory and analgesic effects in cells and animals, and the effect is equivalent to or better than that of ibuprofen. The robiniatin has good safety in cells and animals.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The present invention relates to the application field of traditional Chinese medicine technology, and discloses an application of a formula of effective ingredients of Guizhi tangnausea in treating rest pain caused by diabetes. The present invention includes the composition and corresponding proportion of the formula of effective ingredients of Guizhi tangnausea, the optimal ratio and preparation type of each ingredient of the formula of effective ingredients of Guizhi tangnausea, and the application type of the formula of effective ingredients of Guizhi tangnausea in treating rest pain caused by diabetes. Combined with the behavioral pain test of rats and the clinical trial of lower limb arteriosclerosis, it is illustrated that the formula of effective ingredients of Guizhi tangnausea has a good analgesic effect and an effect of relieving lower limb arteriosclerosis in treating rest pain caused by diabetes.

The invention discloses an acupuncture anesthesia system which comprises a grounding device, a wire and an acupuncture needle, one end of the grounding device is used for being conductively connected with the ground, the other end of the grounding device is conductively connected with one end of the wire, and the other end of the wire is conductively connected with the acupuncture needle; negative electrons in the ground can sequentially flow through the grounding device, the wire and the acupuncture needle to enter acupuncture points and blood of a human body or an animal body. The grounding device is directly communicated with the ground, and a ground super-large capacitor is used as a stable electron source; efficient and stable electron transmission is realized through a conductive path constructed by a wire; by means of an automatic electronic conduction path formed by the grounding device, the wire and the acupuncture needle, negative electron injection and analgesia can be continuously carried out for a long time without continuous manual operation, and therefore the analgesia effect of needle anesthesia is comprehensively improved.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.