38 results about "Analgesic effect" patented technology

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application discloses a heterocyclic compound, a pharmaceutical composition thereof, intermediates thereof, and a preparation method and application of the heterocyclic compound. Specifically provided is a compound shown in formula (A) or a pharmaceutically acceptable salt thereof. The compound of the application has one or more of the following effects: (1) the compound has inhibitory activity on Nav1.8; (2) the compound has good solubility; (3) the compound has good analgesic effect; (4) the compound has good pharmacokinetic characteristics; (5) the compound has fast onset; (6) the compound is rapidly absorbed orally; and (7) the compound meets the requirements of injection administration.

This invention discloses the application of low-concentration topical anesthetics in ophthalmic surgery, relating to the field of low-concentration topical anesthetic application technology, including the following specific application process: confirming the patient's basic surgical condition before administration; selecting anesthetic drugs and optimizing the administration concentration; performing administration according to the specific situation; real-time dynamic monitoring and adjustment of the administration dosage; gradually reducing the drug and transitioning to withdrawal. This invention improves drug safety and patient compliance while ensuring analgesic effects by optimizing anesthetic drug concentration and administration method. Furthermore, by using topical anesthetics at concentrations lower than conventional anesthetics for local administration after ophthalmic surgery, it can effectively relieve postoperative pain, discomfort, and foreign body sensation while significantly reducing toxic effects on corneal epithelial cells, reducing delayed corneal healing, dry eye, and corneal damage. It is effectively applicable to analgesia management after pterygium excision, refractive surgery, and other common ophthalmic surgeries, and has good clinical application value.

The application discloses a composition for treating lumbar intervertebral disc herniation and repairing annulus fibrosus, relates to the technical field of traditional Chinese medicine compositions, and comprises the following raw materials: radix rehmanniae preparata, plastrum testudinis, fructus psoraleae, eucommia ulmoides oliver, walnut kernel, bee pollen, ligustilide, saikosaponin A, salvianolic acid B, ferulic acid, calycosin, stibene glycoside, prunol, loganin, hydroxysafflor yellow A and ligustilide. Experiments show that the composition can strengthen the repair of annulus fibrosus, has anti-inflammatory and analgesic effects, protects collagen, inhibits degeneration, can effectively treat lumbar intervertebral disc herniation and realize the structural repair of damaged annulus fibrosus, and provides a new technical scheme for the clinical treatment of lumbar intervertebral disc herniation.

The present application provides a kind of polyglycolated ropivacaine derivative, with the structure of PEG-D p The PEG polyglycolated ropivacaine derivative described is significantly longer in analgesic duration compared to ropivacaine hydrochloride, and the analgesic effect of the double-end polyglycolated ropivacaine derivative is better than that of the four-arm or eight-arm polyglycolated ropivacaine derivative.

The application discloses a perceptual training device, and relates to the technical field of medical devices, which comprises a stimulation component, a voice recognition component and a control component; the control component is used for generating a perceptual training task; the stimulation component is attached to a target area on the body of a user; the stimulation component can apply stimulation to the target area based on the perceptual training task; the voice recognition component is used for obtaining a voice signal fed back after the user recognizes the stimulation applied to the target area; the control component is used for recognizing the voice signal, obtaining a text signal, and judging whether the text signal matches the perceptual training task; and the user is further subjected to perceptual training according to the settings subsequently. The application can provide instant analgesia; the central remodeling effect can be generated due to the simultaneous perceptual training; the cognition of pain can be improved; and thus, a more durable analgesic effect can be achieved.

This invention provides a traditional Chinese medicine preparation for warming the meridians, dispelling cold, promoting blood circulation, and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following medicinal materials in parts by weight: 30-60 parts of *Banbianqi*, 20-50 parts of *Shancigu*, 30-60 parts of *Tianwencao*, 30-60 parts of *Zijingpi*, 30-60 parts of *Shufu*, 30-60 parts of *Shuitianqi*, 30-60 parts of *Shibazheng*, 30-60 parts of *Ligeng*, 30-60 parts of *Jiejiecha*, 30-60 parts of *Xuchangqing*, 30-60 parts of *Yunlanxiang*, 30-60 parts of *Baimu*, 30-60 parts of *Ligusticum striatum*, 20-50 parts of *Zhuifengsan*, 20-50 parts of *Shanhaitang*, 20-50 parts of *Dengzhanxixin*, and 20-50 parts of borneol. The formula is rationally combined, warming and invigorating blood circulation, and eliminating dampness and unblocking the meridians. Together, they achieve the effects of warming the meridians and unblocking the meridians, dispelling cold and dampness, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. The traditional Chinese medicine preparation of this invention has significant analgesic and analgesic effects, and can maintain the analgesic effect for a long time. At the same time, it has significant anti-inflammatory and swelling-reducing effects. When applied externally, it can directly reach the blocked meridians and joints to relieve symptoms such as pain, numbness, heaviness, and difficulty in flexion and extension of muscles, tendons and joints caused by cold and dampness obstruction.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

This invention provides the application of fasudil in the preparation of a drug for the prevention and / or treatment of neuropathic pain following spinal cord injury, relating to the field of pharmaceutical technology. Experimental data show that fasudil can significantly improve the pain behavior of rats with spinal cord injury, and its mechanism of action may be related to the inhibition of Rho / ROCK signaling pathway activation. Further studies have found that fasudil intervention during the acute phase of spinal cord injury can produce a relatively long-lasting analgesic effect, showing promising application prospects.

Provided are a tetrodotoxin conjugate, a method for preparing same, and use thereof. A carboxyl-containing macromolecular compound and tetrodotoxin are used as the starting materials, and after a catalyst and a solvent are added, the tetrodotoxin conjugate is obtained by means of a coupling reaction. The carboxyl-containing macromolecular compound is selected from carboxylated dextran, carboxylated β-cyclodextrin, alginic acid, and polyacrylic acid. The tetrodotoxin conjugate can be used in the preparation of a sodium channel blocker and a medicament for treating neuropathic pain caused by chemotherapy, and possesses an analgesic effect associated with tetrodotoxin (TTX). In addition, the therapeutic window is increased, thereby greatly improving the safety.

The utility model relates to a cold compress analgesic device for postoperative nursing of oral cavity, including gauze mask unit, a plurality of cold compress units, a plurality of analgesic units, first fixed unit and second fixed unit. Its advantage lies in, and the gauze mask unit is worn in the place of suffering with the gauze mask form to carry out analgesia and cold compress with analgesic unit, cold compress unit respectively with gauze mask unit is detachably connected, and utilizes first fixed unit and second fixed unit, not only can liberate patient's both hands, and can be closely combined with the place of suffering, and the use is flexible, convenient, and the cold compress, analgesic effect is good, and the gauze mask unit is set up in the region, can carry out cold compress and analgesia to maxillary region, mandibular anterior tooth area, mandibular posterior tooth area respectively, improves patient's comfort.

This invention belongs to the field of biomedical technology, specifically relating to an ointment and its application. The toad oil used in this invention differs significantly in composition from toad venom, and its ointment is effective for various acute and chronic pain conditions. Animal experiments have confirmed that the toad oil ointment significantly reduces the frequency and delays the onset of acetic acid-induced writhing responses, demonstrating a clear analgesic effect. Clinical studies have shown that this ointment is rapidly effective and has a definite therapeutic effect on acute gout attacks, postherpetic neuralgia, and arthritis-related pain and swelling. The formulation effectively improves drug retention and user comfort, and no skin irritation has been observed. This development achieves comprehensive utilization of toad resources, providing an example for the sustainable development of traditional Chinese medicine and the efficient utilization of biological resources.

This invention belongs to the pharmaceutical field and specifically relates to magnesium hydroxide nanoparticles for treating joint pain and a method for preparing the same. The preparation method is as follows: a soluble magnesium salt is dissolved in purified water to obtain a magnesium salt solution; a soluble metal hydroxide is dissolved in purified water to obtain a metal hydroxide solution; a phospholipid is dissolved in an organic solvent to obtain a phospholipid solution; the phospholipid solution is removed by rotary vapor deposition to remove the organic reagents; after a thin film is formed, the magnesium salt solution is added to hydrate it to obtain a hydrated solution; the metal hydroxide solution is added to the hydrated solution to perform nano-processing; and the process is completed. The preparation method is simple and easy to control, and magnesium hydroxide nanoparticles can be prepared using only magnesium salt, hydroxide, and phospholipid. Verified by rat studies, after preparing magnesium salt into nano-level magnesium hydroxide using pharmaceutical formulation technology, it has joint analgesic effects, the duration of analgesia is significantly extended, the frequency of administration is greatly reduced, and thus the patient's suffering can be reduced.

This invention discloses a suppository for treating endometritis in cattle and sheep, its preparation method, and its application, belonging to the field of veterinary drug preparation technology. The suppository uses Salvia miltiorrhiza, Coptis chinensis, Forsythia suspensa, Carthamus tinctorius, Borneol, and Astragalus membranaceus as active ingredients. Coptis chinensis and Forsythia suspensa clear damp-heat, while Salvia miltiorrhiza and Carthamus tinctorius unblock stagnation. Astragalus membranaceus replenishes postpartum qi deficiency, promotes blood circulation, enhances blood circulation, strengthens the body's resistance to pathogens, prevents inflammation recurrence, harmonizes the cold properties of other herbs, and reduces side effects. Borneol, with its pungent and penetrating properties, guides the medicine directly to the lesion, promotes mucosal repair, increases mucosal permeability, relieves pain and itching, and synergistically provides anti-inflammatory and analgesic effects, improving the user experience. It is suitable for local suppository administration, aligning with the principles of traditional Chinese veterinary medicine for endometritis, simultaneously exerting the effects of clearing heat and dampness, promoting blood circulation and removing blood stasis, and tonifying qi and strengthening the body, addressing both the symptoms and the root cause. By adding a matrix and excipients and combining vaginal administration to treat endometritis in cattle and sheep, the local drug concentration is concentrated for rapid onset of action, achieving a balance between effectiveness, convenience, and safety.

FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to neurology, traumatology, and orthopedics. It can be used in the treatment of pain syndrome in patients with osteoarthritis of large joints. The method involves conducting 5-10 xenon therapy procedures using the Carboxica device. The drug is injected subcutaneously, para-articularly around the joint at a distance of 2-3 cm from each other, with an interval of 48 hours. The xenon dosage per procedure is 5 ml / kg of the patient's weight.EFFECT: method is available, increases the effectiveness of treating pain syndrome in patients, and has a long-term analgesic effect.1 cl, 3 tbl, 3 ex

1. The name of the design product: ice bag. 2. The use of the design product: for ice on the skin cooling, swelling, shrink pores, analgesic effect, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The application relates to the technical field of medicines, and particularly discloses a class of celecoxib derivatives, a preparation method and application thereof. The derivative is formed by connecting celecoxib and straight-chain amino acids through a chemical bond, and the straight-chain amino acids are glycine, gamma-aminobutyric acid and the like. The derivative or a pharmaceutically acceptable salt and a pharmaceutical composition thereof can be used for preparing medicines for preventing and / or treating pain or nervous system diseases. The derivative has excellent water solubility, strong COX-2 inhibitory activity, good analgesic activity and anti-inflammatory activity, has good analgesic effects on inflammatory pain, neuropathic pain and visceral pain and the like, and has a wide application prospect.

The application discloses application of anterior piriform cortex GABAergic neurons as an analgesic target point, and relates to the technical field of neuroscience and pain. GABA The application discloses that the neural loop (APC GABA →MD) from the anterior piriform cortex GABAergic neurons to the thalamic dorsal medial nucleus plays a key role in pain regulation. Experiments prove that the loop can not only relieve acute pain, but also has a significant analgesic effect on the clinical treatment of intractable chronic inflammatory pain and neuropathic pain models, and shows a wide treatment application prospect.

The present invention relates to use of botulinum toxin type E for preventing or treating neuropathic pain, and specifically, to a pharmaceutical composition comprising botulinum toxin type E for preventing or treating neuropathic pain, and a surgical operation analgesic comprising botulinum toxin type E as an active ingredient. The botulinum toxin type E of the present invention has an analgesic effect by significantly inhibiting neuropathic pain, and, after a single administration, the botulinum toxin type E of the present invention can alleviate side effects and provide an analgesic effect superior to that of Gabapentin, which is a conventional analgesic used for treating neuropathic pain, in mechanical allodynia caused by mandibular alveolar nerve injury. In addition, the botulinum toxin type E of the present invention has a short duration of analgesic action in the body after administration so as to enable faster recovery and rehabilitation than after administration of botulinum toxin type A, and thus can be effectively used for treatment of neuropathic pain.

This invention discloses a wearable multimodal physical stimulation control method and device for chronic pain management, belonging to the field of wearable stimulation device technology. It includes setting intensity levels for different stimulation modes; collecting feedback data and establishing an optimal stimulation mode through a mode determination method; prioritizing stimulation modes other than the dominant stimulation mode under the optimal stimulation mode and determining stimulation parameters; during stimulation, adjusting different stimulation modes based on feedback data and priority ranking, and updating stimulation parameters; when the user adjusts the intensity level of the dominant stimulation mode, first determining temporary stimulation parameters, using these temporary parameters for stimulation while updating the stimulation parameters through feedback adjustment. This invention produces the most direct pain management effect on different causes of pain through different dominant stimulation modes, and achieves multimodal fusion stimulation by employing multiple different auxiliary stimulation modes, improving analgesic effects and relieving discomfort symptoms.

The application discloses a painkilling preparation containing radix scophulariae and radix aconiti and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is a transdermal patch, which is composed of a backing layer, a drug depot layer and an anti-sticking layer. The drug depot layer contains traditional Chinese medicine active ingredients and patch auxiliaries such as pressure-sensitive adhesive and transdermal absorption accelerators. The traditional Chinese medicine active ingredients take radix scophulariae and radix aconiti as the core drug pair, and are supplemented with one or more of the following drugs: qi-regulating analgesic drugs, blood-removing qi-regulating drugs, blood-activating analgesic drugs, blood-stasis-removing analgesic drugs, warm-qi-activating cold-dispelling drugs, wind-dispelling cold-dispelling drugs and external analgesic drugs. The application is a modern traditional Chinese medicine external preparation prepared by a patch technology, and the drug can penetrate the skin and directly reach the lesion, thereby playing a therapeutic role on inflammatory pain, cancer pain and idiopathic pain. The preparation has the characteristics of large drug loading, good transdermal absorption, fast analgesic effect, long-acting effect and avoidance of oral toxicity risk.

This invention discloses a multifunctional medical repair ozone oil composition and its preparation method, belonging to the technical field of medical external care preparations. The composition uses 1%–60% ozonated oil and animal repair oils as its core components, and can selectively add petrolatum, vitamin E, chitosan, and natural plant fragrance essential oils. The surgical skin-specific formula can add peppermint and borneol to enhance penetration, while the gynecological formula is gentle and non-irritating. This product has multiple effects, including antibacterial and anti-inflammatory properties, antipruritic and analgesic effects, moisturizing and repairing properties, and promoting the healing of mucous membranes and skin wounds. It is suitable for gynecological intimate care, surgical skin repair, and can also be applied externally to the back to soothe respiratory discomfort and to the abdomen to relieve abdominal pain and bloating. It has a wide range of applications, high clinical value, and is suitable for large-scale production and clinical promotion.

The application discloses a TENS and iontophoresis composite closed-loop analgesic patch, and belongs to the field of medical devices. The patch comprises a flexible substrate, a multi-modal sensor array, a transcutaneous electrical nerve stimulation unit, an iontophoresis drug delivery unit, a control module and a multi-level safety control unit. The sensor array collects surface electromyography signals and cutaneous electric response signals, and the control module calculates a pain probability value and executes a hierarchical control strategy: standby when the pain probability value is below a first threshold value, only activate the TENS unit when the pain probability value reaches or exceeds the first threshold value but is below a second threshold value, and simultaneously activate the TENS unit and the iontophoresis drug delivery unit after dose safety confirmation when the pain probability value reaches or exceeds the second threshold value. The multi-level safety control unit comprises a dose counter and a sensor detachment detection module, which are used for preventing drug overdose and accidental triggering. The application combines physical analgesia and chemical analgesia, realizes double analgesic effects of "instant + continuous", and guarantees the safety of home use through a multi-level safety mechanism.

This invention belongs to the field of pharmaceutical technology, specifically relating to the use of tropic acid and its derivatives in the preparation of drugs for treating immune and inflammation-related diseases, and to drugs for treating immune and inflammation-related diseases. The tropic acid and its derivatives are compounds of formulas I-IV or pharmaceutically acceptable salts thereof, as well as solvent compounds, enantiomers, diastereomers, tautomers, or mixtures thereof in any proportion, including racemic mixtures, of the compounds of formulas I-IV or pharmaceutically acceptable salts thereof. Animal studies show that tropic acid and its derivatives have broad-spectrum immunomodulatory, anti-inflammatory, and analgesic effects, significantly improving pathological indicators in numerous animal models of immune and inflammation-related diseases. They can regulate abnormal immune responses towards normalcy and exert good anti-inflammatory and analgesic effects, making them suitable for patients with different disease degrees and types of immune and inflammation-related diseases, and thus have industrial applications.

This invention discloses a zinc-quercetin nanocomposite, its preparation method, and its pharmaceutical applications, belonging to the field of bionanomaterials technology. This nanoparticle employs a carrier-free self-assembly strategy, directly forming a structurally stable nanocomposite by combining the natural flavonoid quercetin with zinc ions through metal-organic coordination bonds. This technology effectively overcomes the inherent defects of poor water solubility and low bioavailability of quercetin monomers, resulting in a nanocomposite with good water solubility and physiological stability. Simultaneously, zinc ions, as a key trace element for neuroregulation, can intervene in pain transmission pathways to alleviate pain; quercetin exerts a long-lasting anti-inflammatory and analgesic effect by continuously scavenging reactive oxygen species and inhibiting the release of inflammatory factors in damaged nerves or inflammatory sites. The two work synergistically in the lesion microenvironment, achieving the prevention and efficient, safe treatment of chronic pain. The preparation process is extremely simple, requiring no complex carriers, and has broad prospects for clinical translation and application.

This invention provides a method for preparing hydromorphone and dihydromorphine-like drugs via polyethylene glycol modification and their applications, which have the compound structure shown in general formula (I). The compounds provided by this invention reduce lipid solubility through polyethylene glycol modification, thereby slowing the rate of crossing the blood-brain barrier, slowing the release rate, prolonging the duration of action, and reducing the possibility of abuse. At high doses, they exhibit analgesic effects comparable to opioids, without producing side effects such as respiratory depression or addiction, demonstrating good safety.

The application discloses a new use of sildenafil and its salts in combination with ibuprofen. Through pharmacodynamics and toxicology experiments, the application first proposes and verifies that the combination of sildenafil and its salts (sildenafil citrate) and ibuprofen has a significant synergistic effect in treating inflammatory pain, and can effectively reduce the renal toxicity induced by long-term administration of ibuprofen. The application solves the problem that long-term or large-dose use of ibuprofen can induce significant renal toxicity, which seriously limits the long-term, standard and sufficient clinical application of ibuprofen. The composition provided by the application can enhance the analgesic effect of ibuprofen and reduce the renal toxicity of ibuprofen, and has important clinical conversion value and practical application prospect.

The present application relates to polypeptides, in particular to an animal toxin polypeptide and application thereof. The polypeptide is identified by RNA sequencing of centipede transcriptome, and bioinformatics screening and Motif scanning analysis of translated protein sequence. Experimental results show that SM-8 shows strong analgesic effect in various pain models, including hot plate test, acetic acid writhing test, formalin inflammatory pain model and migraine model, and the analgesic effect is equivalent to that of butorphanol tartrate and sumatriptan. Molecular mechanism research shows that SM-8 can regulate the expression of pain-related genes. Preliminary safety evaluation by mouse open field test shows that the polypeptide does not cause obvious toxic side effects, has good safety, and has good prospects for development into a new polypeptide analgesic drug.