71 results about "Articular cartilage" patented technology

Embodiments of the present invention relate generally to implant placement into bone. More specifically, embodiments of the invention relate to implant placement across the sacroiliac joint. Placement can be facilitated using various CT imaging views that allow the implants to be placed in bone associated with articular cartilage.

A method of treating osteoarthritis by modifying the shape change of bone(s) underlying articular cartilage, comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint is disclosed.

The invention discloses a spring probe system for rapid registration of articular cartilage based on 3D printing, and relates to the technical field of medical imaging and orthopedic surgery navigation. The problem that the joint registration precision is insufficient due to the fact that cartilage cannot be developed in traditional CT imaging is solved. Through personalized customization of the 3D printing guide plate, convenient installation of positioning holes, adjustability of the spring probe assembly and real-time data monitoring, and automatic data processing of the intelligent registration module, manual operation is reduced, the operation efficiency is improved, the spring probe assembly is reasonable in structure and adjustable in elastic force, stable operation of the system in an operation is guaranteed, and the operation safety is improved. Multi-position CT scanning is combined with an advanced image processing and registration technology, an accurate initial model is constructed, a spring probe assembly collects data and is combined with an elastic deformation compensation model to correct registration errors in real time, the registration accuracy is improved, reliable support is provided for orthopedic surgery navigation, the surgery success rate can be improved, and patient wounds and surgery risks are reduced.

The invention provides a multi-task consistency segmentation network method for cartilage segmentation based on a deep shape prior model, belongs to the field of cartilage joint segmentation network training in multi-modal MRI, and solves the hard segmentation problem under the conditions of complex image background, small training data volume and the like. According to the method, the concept of shape feature description is defined and comprises the inner side surface, the mask segmentation and the contour shape, the cartilage segmentation network based on inner side surface modeling, the mask segmentation and the contour shape is established, the cooperative improvement problem among multiple tasks is solved, and the consistency of the multiple tasks is achieved; the concept of shape prior description represents the shape distribution of the articular cartilage; a neural network model based on shape prior description is established; a shape prior network model is introduced into a multi-task consistency segmentation network. Through the guidance of shape feature description and the constraint of shape prior description, a very different deep learning network framework is established, and the method has very high accuracy and strong generalization ability.

The invention relates to a device and a method for detecting the retention performance of a liquid-phase solute of articular cartilage. The method comprises the following steps: adhering and fixing a treated cartilage on a perforated rubber plug; the cartilage pasted with the rubber plug is placed in a retention device with a perforated plate at the bottom, and water is added till the cartilage completely exceeds an overflow opening; the retention pressing rod provided with the rubber plug is pressed into the retention device, and whether liquid leakage exists or not is detected in advance; discharging the water, adding a solution required by a retention experiment, and pressing the retention pressure rod again; the retention device is arranged in the cylindrical base, and the screws on the two sides are fastened; the base of the device is fixed on a lower disc of a testing machine; a retention compression bar of the device is fixed on an upper disc of a testing machine; and setting expected pressure and time, starting to load experimental pressure, and then starting a cartilage retention experiment. And after the retention experiment is finished, observing the retention state of the fluorescent solute molecules by using a slicing machine and a laser confocal microscope. The cartilage liquid phase solute retention performance is effectively detected, the problem that sealing performance is difficult in a retention experiment is solved, a cartilage mass transfer research method is expanded, and the detection precision and stability are improved. The method is expected to be popularized to become a standard test technology of cartilage retention performance, and plays a positive role in promoting cartilage in-vitro experiments.

The invention discloses a device and method for concentrating an articular cartilage regenerated collagen solution, and relates to the technical field of collagen concentrating devices.The device comprises a concentrating tank, an ultrafiltration membrane separator, a vacuum pump and an electromagnetic stirrer are installed on the top side of the concentrating tank, and a heating coil is installed on an interlayer of an inner tank body and an outer tank body of the concentrating tank; a heating coil is arranged in the concentration tank, an electric heating wire is arranged in the heating coil, a rotor is arranged on the inner wall of the top side of the concentration tank, the rotor is coupled with an electromagnetic stirrer, and a ventilation mechanism used for heating and introducing inert gas and disturbing water flow in the heating coil is mounted on the heating coil. The heating inert gas is in direct contact with the collagen solution, uniform heating is achieved, collagen denaturation is prevented, the viscosity of the collagen solution is reduced, the gas drum membrane is continuously shrunk and expanded through the intermittently introduced inert gas, water flow in the heating coil pipe is disturbed, uniform heating is facilitated, and scaling is prevented at the same time.

To provide a compound and the use thereof for the treatment for regeneration of connective tissue following the degeneration process of articular cartilage due to osteoarthritis, in the case of humans, the degeneration process of articular cartilage caused by excessive stress, for the treatment of skin aging, and for the prevention of skin cancer.SOLUTION: For example, an amino acid derivative of glucosamine having the following structure is provided.SELECTED DRAWING: None

The application belongs to the technical field of biomedical materials, and discloses a collagen-based double-network porous hydrogel scaffold capable of recruiting endogenous stem cells and a construction method and application thereof. The scaffold takes collagen II (Col-II) and oxidized methyl acrylated hyaluronic acid (AHAMA) as an organic phase, and is constructed into a physical / chemical double-network structure through Schiff base dynamic crosslinking and ultraviolet light-induced methacryl radical polymerization. An air-in-water emulsion template method is used to form a through-porous structure, and 5' aldehyde-modified nucleic acid aptamer Apt19S is anchored in the scaffold network to achieve specific recruitment of endogenous pluripotent stem cells. The scaffold has excellent mechanical properties, a biomimetic extracellular matrix microenvironment and a targeted stem cell recruitment function, can effectively promote the directional differentiation of stem cells into chondrocytes, avoids the immune rejection and ethical issues caused by exogenous stem cell transplantation, and is suitable for the field of articular cartilage defect repair.

The present invention relates to the technical field of joint repair hydrogels, and in particular to a three-dimensional biohydrogel and its preparation method and application. The three-dimensional biohydrogel, by weight, comprises: 1-5 parts of methacrylic anhydride hyaluronic acid HAMA, 0.05-0.15 parts of initiator, 3-8 parts of hydrogenated soybean phosphatidylcholine liposomes and 7-13 parts of stem cell solution; the preparation method of the stem cell solution is: gelatin and water are mixed to obtain a gelatin solution; stirring at 40-60 ° C to prepare a dispersed phase; adding an emulsifier to the oil to prepare a continuous phase; the dispersed phase and the continuous phase are prepared by microfluidic technology to obtain uniform droplets, and the droplets are freeze-dried to obtain gelatin microspheres; stem cells are added to the gelatin microspheres and incubated at 25-37 ° C for 2-4 hours to obtain a stem cell solution. The present invention has long-lasting efficacy and significant safety, and can fundamentally repair articular cartilage.

The invention discloses a suture-containing anchor device for fixing articular cartilage stripping and a fixing method. The device comprises an anchor, a soft needle, a buckle cylinder and a suture; the anchor is made of titanium alloy absorbable materials and is provided with a double-spiral decompression groove and a suture channel. The suture is made of eight strands of ultra-high molecular weight polyethylene coated with polylactic acid, one end is fixed with the anchor, and the other end is welded with a nickel-titanium alloy soft needle through laser; the buckle cylinder is detachable and wraps the suture and the soft needle connecting section. The method comprises the following steps: resetting a bone block and temporarily fixing the bone block, drilling a central bone tunnel, implanting an anchor nail, installing a buckle cylinder, then enabling a soft needle with a suture to penetrate out, drilling a peripheral bone tunnel, threading into a tension band in a bundle splitting manner, adjusting the tension to 0.5-1.2 N / mm < 2 >, and then combining and locking the SMC sliding knot and the surgical knot. Minimally invasive fixation is achieved, mechanical stability and tension uniformity are improved, and cartilage healing is facilitated.

The invention discloses a joint health-care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method, and relates to the technical field of medical health care. The joint health-care tablet comprises the following components: glucosamine hydrochloride, sodium chondroitin sulfate, a frankincense extract, an aesculus chinensis extract, microcrystalline cellulose, povidone, croscarmellose sodium and silicon dioxide. Through scientific proportioning of various active components such as the glucosamine hydrochloride, the chondroitin sulfate sodium, the frankincense extract and the aesculus chinensis extract, comprehensive protection of joint health is realized, the glucosamine hydrochloride and the chondroitin sulfate sodium are used as basic components, repair and regeneration of articular cartilage are promoted, and the joint health is improved. Boswellic acid compounds in the frankincense extract and aescin in the aesculus chinensis extract have anti-inflammatory and analgesic effects and can effectively relieve arthralgia and inflammation, multiple effects are synergistic, and the joint health care effect is improved.

A miniature bone mounted robot configured to perform minimally invasive orthopedic surgery coupled with regenerative three-dimensional bio-printing technology to restore cartilage and affected bone. The robot uses a sensor device attached to a holder affixed to the robot activated arm, to map the three-dimensional surface of the bone surface to be treated. The sensor may be a touch sensor, an optical imaging device, or another tool for mapping the bone surface. The robot shapes and prepares the bone surface and subsequently deposits a bio-ink implant in a three-dimensional pattern mimicking the original shape and depth of the articular cartilage. Because the entire procedure is conducted through the robotic platform rigidly mounted on the patients bone, there is no need for registration to preoperative three dimensional images, or for intraoperative tracking. Cell deposition based on mapping of the actual three dimensional anatomy, ensures an optimal outcome.

This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.

The invention discloses an application of a cathepsin D inhibitor in preparation of a medicine for preventing or treating osteoarthritis, and an application of the cathepsin D inhibitor in preparation of a medicine for inhibiting degradation of type II collagen and / or articular cartilage. The invention relates to an application of a cathepsin D inhibitor in preparation of drugs for inhibiting expression of cathepsin D in bone joints. In the application, the cathepsin D can effectively relieve tissue lesions of osteoarthritis.

To provide a knee supporter capable of allowing a user to get at an ideal walking style and suppressing the abrasion of the articular cartilage of the leg due to the extension of the knee.SOLUTION: A knee supporter 1 includes a body part 2 which is substantially cylindrically attached from the femoral region to the crural region. The knee supporter comprises stretchable belts 3a and 3b which are spanned between the upper portion and the lower portion of the body part 2 and restrict extension of the knee by a tensile force, and stays 4a and 4b which vertically extend on at least one side of the left and right sides of the body part 2 and are rotatable around hinges 13 in response to bending of the knees. The rotation of the stays 4a and 4b is restricted so as not to be in a non-flexible state, that is, a fully extended state where an upper stay 11 and a lower stay 12 are linearly arranged in the vertical direction so that a flexion angle θ is 0°.SELECTED DRAWING: Figure 4

Provided is a highly safe articular cartilage regeneration material. This articular cartilage regeneration material contains: a scaffold-free artificial tissue in which synovial-derived mesenchymal stem cells cultured with a serum-free medium form a three-dimensional structure; and an extracellular matrix derived from mesenchymal stem cells. The articular cartilage regeneration material is implanted so as to be attached to a site of lost or damaged articular cartilage.

A formulation for use in treating osteoarthritis by modifying the shape change of bone(s) underlying articular cartilage is disclosed. The use comprises evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.

The invention discloses a gel ointment for treating osteoarthritis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, and the key point of the technical scheme is that the gel ointment comprises the following preparation raw materials in parts by mass: 1 part of cepharanthine, 25 parts of a gel skeleton component, 0.4 part of a cross-linking agent, 0.01 part of an acidic pH regulator, 0.3 part of an alkaline pH regulator and 60-85 parts of a solvent; the pH (Potential of Hydrogen) value of the gel ointment is 6.5 to 8.2. Aiming at the clinical characteristics and the current treatment situation of osteoarthritis, the traditional Chinese medicine and the modern medicine dosage form are combined, and the articular cartilage protection effect of cepharanthine and the administration characteristic of the gel ointment are combined, so that the traditional Chinese medicine gel ointment for treating osteoarthritis through transdermal administration is researched and developed. And a new treatment choice is provided for patients with osteoarthritis.

The present invention relates to novel long non-coding RNAs (lncRNA) involved in the regulation of hypertrophy of chondrocytes, wherein RUNX2 was regulated at the post-translational level during hypertrophic differentiation of the chondrocyte cell line TC28a2 and two novel RUNX2-binding lncRNAs among numerous lncRNAs were identified, leading to the present invention. It is expected that bone-related diseases can be diagnosed by measuring the expression of the identified specific lncRNAs, and furthermore, the vascularization or calcification of articular cartilage can be effectively suppressed by inhibiting the hypertrophy of chondrocytes through inhibiting the expression of the identified specific lncRNAs, which is expected to be highly effective in the prevention or treatment of bone-related diseases.

The application provides a compound preparation for improving osteoporosis and osteoarthritis, a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound preparation contains the following raw materials: glutathione, curcumin, calcium carbonate, vitamin D3, hydrolyzed collagen, and glucosamine sulfate; wherein the glutathione exists in the form of a cyclodextrin inclusion compound. The preparation method comprises the following steps: mixing the calcium carbonate, the hydrolyzed collagen, the glucosamine sulfate and excipients, then adding an equal amount of a premix of the glutathione cyclodextrin inclusion compound, the curcumin and the vitamin D3 in a stepwise manner, and performing dry granulation and tabletting to obtain the compound preparation. The compound preparation can simultaneously increase bone density, protect articular cartilage, reduce the levels of oxidative stress and inflammation, and can be used for preparing medicines or health foods for preventing or adjuvant treating osteoporosis and osteoarthritis. The application has a scientific formula, a stable process and a good application prospect.

The invention discloses an articular cartilage MRI (Magnetic Resonance Imaging) image intelligent enhancement and contrast optimization system, which belongs to the technical field of medical image processing and comprises a cartilage feature extraction module, a self-adaptive enhancement module, a contrast optimization module and a quality evaluation feedback module, the cartilage feature extraction module realizes cartilage region classification and structural analysis based on T2 relaxation time distribution features and multi-scale structure tensor features; the adaptive enhancement module performs differential enhancement according to the region type and the structural feature; the contrast optimization module realizes contrast dynamic optimization through nonlinear mapping and edge gradient adaptive adjustment; according to the articular cartilage MRI image display system and method, the display quality of the articular cartilage MRI image is remarkably improved, the cartilage display definition is improved by 73% or above compared with that of an original image, and a high-quality imaging basis is provided for accurate diagnosis of chondropathy.

The present invention is to provide a 3D cartilage organoid block prepared by differentiating mesenchymal stem cells into 3D spheroid cartilage tissues, a basic unit for the 3D cartilage spheroid block. The inventors found that both the amount of GAG matrix and the expression of the collagen type2 increased. Therefore, the method of this invention provides clinically applicable cartilage tissues by effectively enhancing the function of the cartilage differentiation constructs according to 2D culture. The 3D cartilage organoid block can be usefully applied to the area, such as, articular cartilage regeneration and plastic surgery, where cartilage tissues restoration is required.

The invention discloses a method for preparing a Pickering emulsion bionic synovial fluid of Chinese herbal volatile oil, and relates to the technical field of biolubricants. The method comprises: adding nanoparticles to ultrapure water, and ultrasonically dispersing to obtain a nanoparticle dispersion; adding Chinese herbal volatile oil to the nanoparticle dispersion according to a certain volume fraction, and ultrasonically stirring to obtain a Pickering emulsion bionic synovial fluid of Chinese herbal volatile oil. The Pickering emulsion bionic synovial fluid of Chinese herbal volatile oil prepared by the invention has excellent friction reduction and anti-wear properties at the interface of artificial joints and articular cartilage, and can effectively remove active oxygen free radicals in the environmental system, and can inhibit and alleviate the onset of osteoarthritis from the two aspects of controlling mechanical stress and reducing oxidative stress.

A system and method for a ROSE-Reverdin / DARE osteotomy obviates severe deformities having a high intermetatarsal angle and which require closure via osteotomy (bone cut) of the first and / or fifth metatarsal in the midshaft or proximal aspect of the bone. The ROSE osteotomy is utilized to achieve this correction and is performed without need for fusion of the first metatarsal cuneiform joint. The ROSE osteotomy achieves correction of the intermetatarsal angle via rotation of the first and / or fifth metatarsal about a proximal based axis point. The Reverdin / DARE osteotomy is required to correct a deviated articular cartilage deformity at the head of the first metatarsal and / or additional slight correction of the IM angle. The Reverdin / DARE osteotomy achieves correction by wedging of the cut to realign the cartilage and translation of the head of the first metatarsal for further IM correction. A unique jig is used to achieve this cut and fixation.

The invention discloses application of irbesartan in preparation of a medicine for preventing or treating osteoarthritis, and belongs to the technical field of biological medicine. Osteoarthritis single cell transcriptome data are integrated and analyzed, differential expression genes are screened, and irbesartan is screened by using a relocation method and Mendel randomization analysis to serve as a medicine for treating osteoarthritis; analysis results show that irbesartan can significantly reduce the risk of osteoarthritis. An irbesartan administration experiment is carried out by using a zebra fish bone arthritis model, and the experiment result shows that irbesartan obviously increases the joint gap of anal fins of zebra fish and has an obvious protection effect on articular cartilage; a transcriptome sequencing result shows that irbesartan plays the role by inhibiting the MAPK signal channel. The invention provides the effect of irbesartan in the development of osteoarthritis for the first time, provides a new strategy for prevention and treatment of osteoarthritis, and has a wide application prospect.

An apparatus and methods are provided for a dermal cap for resurfacing a metatarsal head of the foot or a metacarpal head of the hand. The dermal cap comprises an outer surface having a convex shape, an inner surface having a concave shape, and a rounded peripheral surface joining the inner surface and the outer surface. The inner surface can be placed onto a bone head such that the outer surface provides a bone head surface resembling the original articular cartilage. The outer surface effectively restores the articular cartilage and thus relieves pain and facilitates better joint function. The dermal cap can be formed by stretching it over a rounded mandrel shaped similarly to the size and anatomy of the bone head to be treated. The dermal cap can be freeze-dried on the rounded mandrel to set the desired anatomy of the dermal cap.

The present invention provides an intelligent knee joint with magneto-controlled damping buffer, which includes a prosthetic knee joint and a damping control system; the prosthetic knee joint is connected to the human body and is used to assist the human body in moving. An articular cartilage with magnetorheological elastomer damping buffer is provided inside the prosthetic knee joint for providing a buffering force during the movement of the prosthetic knee joint; the damping control system includes a pressure sensor, a power supply and a control device. The pressure sensor is installed in the articular cartilage. The pressure sensor is electrically connected to the power supply, and the control device is electrically connected to the power supply. The control device receives the pressure data of the articular cartilage fed back by the pressure sensor and adjusts the damping of the magnetorheological elastomer in the articular cartilage. The control device adjusts the output damping of the articular cartilage in real time according to the received pressure value data, so that the articular cartilage can evenly distribute the acting force during actual use, support and buffer the pressure of the knee joint, and improve the use experience.

This invention relates to a polyamino acid-based in-situ cartilage regeneration porous gel scaffold and its preparation method. Phenylboronic acid ester is esterified and linked with polyethylene glycol-modified Kartogenin to obtain phenylboronic acid ester-modified PEGKGN. The PEGKGN modified with phenylboronic acid ester is then grafted onto the side chains of polyamino acids with allyl polyethylene glycol to obtain a graft copolymer PLBPKA. The graft copolymer PLBPKA is blended with small molecules of Kartogenin and a silk fibroin solution to form a drug-loaded self-assembly network under shear force. Finally, the polyamino acid-based in-situ cartilage regeneration porous gel scaffold is constructed through ultraviolet light crosslinking and freeze-phase separation, which is a differentially released drug hydrogel scaffold. Compared with existing technologies, the scaffold of this invention has good biocompatibility and biocontrollable degradation, and can rapidly release drugs in inflammatory environments to promote stem cell migration; while in normal physiological environments, it slowly releases drugs to promote the differentiation of stem cells into cartilage. Therefore, it can promote in-situ regeneration of articular cartilage in the absence of exogenous stem cells.

A measurement system for personalized bone and articular cartilage morphology comprises a database, an image capture module, an image analysis module, a neural network model, a model building module, and a novel computation module. The database is configured to store a dataset. The image capture module is configured to capture a plurality of skeletal images of a subject. The image analysis module is configured to obtain skeletal and cartilage shape parameters through statistical shape modeling and principal component analysis and generate 3D models of the skeleton and cartilage. The neural network model is configured to generate and output skeletal motion parameters based on the input skeletal and cartilage shape parameters. The model building module is configured to generate a personalized joint skeleton and cartilage model based on the 3D models of the skeleton and cartilage and the skeletal motion parameters. The novel computation module is configured to simulate the relative positions of the first bone and cartilage 3D model and the second bone and cartilage 3D model of the subject during exercise based on the personalized joint skeleton and cartilage model, and to calculate an actual cartilage shape and the cartilage wear value of the subject by eliminating overlapping cartilage regions in the first bone and cartilage 3D model and the second bone and cartilage 3D model during exercise.

The utility model discloses a mouse articular cartilage defect modeling micropore drill bit adjusting structure, which belongs to the technical field of drilling tools and comprises a mounting seat assembled at the output end of an electric drill pen, and a hole is formed in the middle of the mounting seat and a sleeve is welded in the middle of the mounting seat. According to the mouse articular cartilage defect modeling micropore drill bit adjusting structure, the locking block matched with the guide part is extruded when the guide part rotates and descends, so that the locking strip deforms and accumulates force, and the reamer is driven to abut against a hole in the drilling process; when the expanding drill rotates, the hole diameter is expanded through the stepped spiral groove of the expanding drill, and the drilling diameter is adjusted; therefore, the drilling depth and diameter are controllable, drill bits of different specifications do not need to be replaced, the operation time is shortened, the modeling efficiency is improved, the modeling quality is improved, the purchase and storage cost of the drill bits is reduced, finally, the flexibility, precision and efficiency of drilling and modeling operation are improved, the cost and the safety risk are reduced, and animal modeling experiment research is facilitated.