14 results about "Lidocaine" patented technology

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The present invention relates to an injection composition for lipolysis, which is safe and effective, and more specifically, to an injection composition for lipolysis, which comprises: one or more compounds selected from the group consisting of hyaluronidase and pentoxifylline, and one or more compounds selected from the group consisting of hyaluronidase, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline and pentoxifylline. 5 to 10% (v / v) of carnitine (Carnitine); and lidocaine (Lidocaine); and normal saline. As a composition having both safety and efficacy, the injection composition for lipolysis of the present invention has an excellent lipolysis effect, does not cause a yo-yo phenomenon over time, and thus has a characteristic of not causing side effects such as skin depression.

Provided are methods for treating trigeminal nerve pain in a subject in need thereof. The method may include administering to the subject by perineural injection of the trigeminal nerve a therapeutically effective amount of a composition comprising an alpha-2 adrenergic agonist, such as guanfacine. The composition may further comprise lidocaine.

This invention discloses a method for preparing a hydrogel composite dressing for post-circumcision care, specifically implemented according to the following steps: Step 1, preparing an MXene nanosheet dispersion; Step 2, preparing a lidocaine-chitosan-gellan gel composite; Step 3, mixing the MXene dispersion from Step 1 with the lidocaine-chitosan-gellan gel composite from Step 2, and adding a menthol derivative to prepare a multifunctional hydrogel composite dressing. This invention also discloses the hydrogel composite dressing prepared by this method. This invention accelerates wound healing through the antibacterial, hemostatic, and epithelial cell regeneration-promoting effects of chitosan; through the photothermal conversion capability of MXene, local mild thermotherapy can be achieved under near-infrared light irradiation, promoting blood circulation and reducing edema, while MXene itself has good antibacterial properties.

The present application belongs to the technical field of nanometer material preparation, and relates to a kind of nanometer medicine, including medicine carrier and active ingredient, medicine carrier adopts amphiphilic polymer, and active ingredient includes photosensitizer Ce6 and analgesic drug LC. The preparation method of the nanometer medicine is also disclosed, comprising the following steps: weighing Ce6, analgesic drug LC and amphiphilic polymer, dissolving in solvent to obtain a mixed solution; the mixed solution is stirred uniformly, and dialyzed in ultrapure water; the solution obtained by dialysis is constant volume, and filtered to obtain nanometer medicine. The nanometer medicine particle size morphology is regular, the particle size is uniform, has good stability within 7 days, can have good enrichment effect at tumor site, and has good photodynamic therapy effect. Lidocaine and photosensitizer reach the lesion site at the same time through intravenous injection, not only reduce the operation steps, but also target the lesion site, reduce the anxiety of patients because they feel that anesthesia will affect intelligence.

The disclosure relates to pharmaceutical formulations comprising of lidocaine and halobetasol propionate, methods of making such formulations, and methods of using such formulations in the treatment of hemorrhoids.

This invention discloses a chitosan-based lidocaine formulation for intra-articular use and its preparation method. Belonging to the field of pharmaceutical formulation technology, the formulation is prepared from chitosan, carboxymethyl chitosan, lidocaine, chitosan-PNIPAM microspheres, sulfated trehalose, and excipients. The chitosan-PNIPAM used in this invention exhibits dual temperature and pH response. With temperature changes, PNIPAM possesses both hydrophobic contractile and hydrophilic swelling states, thereby controlling the lidocaine release rate. Simultaneously, when the pH decreases, chitosan repels PNIPAM, further disintegrating the microspheres to release the drug, thus achieving targeted analgesia. Sulfated trehalose, as a cartilage matrix synthesis promoter, can activate intracellular signaling pathways in chondrocytes, promoting the synthesis of type II collagen and proteoglycans. Simultaneously, the sulfate groups can form electrostatic complexes with the amino groups of chitosan, enhancing drug retention. The formulation of this invention can inhibit synovial cells, release cytokines, and synergistically with carboxymethyl chitosan, increase the inhibition rate of inflammatory factors by 40%-50%.

This invention discloses a method for preparing high-viability fat grafts, comprising: aseptically transferring adipose tissue in a closed system while maintaining complete isolation from air during the transfer; performing multi-stage liquid washing on the adipose tissue, including an initial washing and a secondary washing, to remove blood components, tissue debris, and drug residues; subjecting the washed adipose tissue to gradient centrifugation, including an initial low-speed centrifugation and a secondary high-speed centrifugation, to achieve uniform separation of fat cells through a sieve; and collecting the centrifuged fat grafts to obtain a final product with high cell viability and a high proportion of concentrated stem cells. By combining multi-stage liquid washing with gradient centrifugation, efficient purification and uniform separation of fat cells are achieved, effectively reducing the risk of inflammation and removing harmful residues such as lidocaine, resulting in a final fat graft with a high proportion of stem cells and excellent biocompatibility, supporting regenerative medicine applications.

The present disclosure relates to an injection composition for lipolysis with both safety and efficacy, and more particularly, to an injection composition for lipolysis including at least one compound hyaluronidase and pentoxifylline; 5 to 10% (v / v) carnitine; lidocaine; and a physiological saline. The injection composition for lipolysis according to the present disclosure is a composition with both safety and efficacy, which is characterized by having an excellent lipolysis effect, and having not only no yo-yo effect over time, but also no side effects such as sagging skin.

This invention provides a battlefield wound treatment device for first aid in a battlefield environment, belonging to the field of wound care technology. The device includes a bandage, and further includes: two Velcro straps symmetrically fixed to the outer walls of both ends of the bandage about its central axis; the two Velcro straps can be adhered to each other for quick and secure connection of the two ends of the bandage; a sealing bag detachably connected to the middle section of the bottom wall of the bandage; a drug storage component located inside the sealing bag for temporary storage of chlorhexidine and lidocaine; a pressure bladder fixedly connected to the inner side of the top wall of the sealing bag, its top wall being fixedly connected to the bottom wall of the bandage, and containing distilled water; and an ammonium chloride storage component located on the side wall of the middle section of the pressure bladder for storing ammonium chloride. This design reduces the size of the device, making it lighter and more portable, and enabling wound treatment in a very short time, meeting the needs of rapid rescue in emergency situations.

The utility model belongs to the technical field of medical supplies, concretely relates to disposable spray type anaesthetic laryngeal mirror piece, including hollow light guide block, the arc shape of the inside concave top surface of light guide block extension blocks the tongue, mounting seat, the tongue and light guide block fixed connection, the mounting seat fixed setting is in the first end of light guide block, the first end of light guide block is provided with mounting panel, the mounting panel is fixed with anaesthetic cavity and set up, anaesthetic cavity inside is provided with piston, anaesthetic cavity inside is provided with bag body, the lidocaine of bag body storage has, the first end inner wall of anaesthetic cavity is provided with elastic part, anaesthetic cavity is inserted with locking piece, locking piece is located between elastic part and piston. Through setting up anaesthetic cavity on light guide block, anaesthetic cavity and laryngeal mirror piece are integrated, when carrying out laryngeal mirror examination or operation, do not need additional connection anaesthetic device, simplify operation procedure, improve work efficiency, and one -time -use also avoids the risk of cross infection.

The present application relates to a kind of extracellular vesicle compositions and its preparation method and use, specifically relates to a kind of extracellular vesicle compositions in preparation for the use of drug for preventing and / or treating pain hyperalgesia and / or promoting wound healing, the active ingredients of the extracellular vesicle composition include mesenchymal stem cell-derived extracellular vesicle and lidocaine.The present application can achieve the double goal of "promoting wound healing" and "preventing pain hyperalgesia caused by scald, pain hyperalgesia", fundamentally improve the long-term prognosis of infant scald patient.

The application discloses a low-stimulus and high-safety benzoyl aconine original base temperature-sensitive analgesic gel injection as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The injection takes benzoyl aconine original base as a core analgesic component, constructs a triple heart protection system of'sub-anesthetic dose lidocaine + ammonium glycyrrhizinate + magnesium sulfate', cooperates with a poloxamer 407 temperature-sensitive gel matrix, and is supplemented with a cosolvent and an antioxidant, has a pH value of 5.5-6.5, can be injected at room temperature, and is quickly gelled at body temperature to realize long-acting controlled release. The preparation has high analgesic intensity, no addiction, slight injection pain, controllable cardiotoxicity, and can maintain analgesia for more than 12 hours after single administration, is suitable for local targeted treatment of moderate and severe chronic pain, neuropathic pain and the like, and has significant clinical advantages and popularization value.