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420 results about "Nerve fiber bundle" patented technology
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A nerve is an enclosed, cable-like bundle of axons (nerve fibers, the long and slender projections of neurons) in the peripheral nervous system.
Method and apparatus for selective control of nerve fibers
InactiveUS6600954B2Pain reliefReduced sensationElectrotherapyArtificial respirationFiberNerve fiber bundle
A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a "green wave" effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.
Owner:MEDTRONIC INC
Selective nerve fiber stimulation
InactiveUS20060100668A1Modify heart rate variabilityReduce heart rate variabilityElectrotherapyArtificial respirationNerve fiber bundleControl cell
Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.
Owner:MEDTRONIC INC
Selective nerve fiber stimulation for treating heart conditions
InactiveUS7778703B2Minimizing adverse side effectRegulate heart rateSpinal electrodesHeart stimulatorsNerve fiber bundleStimulus current
Apparatus for treating a heart condition of a subject is provided, including an electrode device, which is adapted to be coupled to a vagus nerve of the subject. A control unit is adapted to drive the electrode device to apply to the vagus nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the vagus nerve. The control unit is also adapted to drive the electrode device to apply to the vagus nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set.
Owner:MEDTRONIC INC
Implantable microstimulators and methods for unidirectional propagation of action potentials
InactiveUS7860570B2Increase stimulationLess power consumptionSpinal electrodesArtificial respirationNerve fiber bundleSide effect
Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and / or less targeted stimulation.
Owner:BOSTON SCI NEUROMODULATION CORP
Techniques for applying, calibrating, and controlling nerve fiber stimulation
InactiveUS20050197675A1Reduce riskFew potential side effectSpinal electrodesHeart stimulatorsNerve fiber bundleFiber
Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off”periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off”duration equal to at least 50% of the “on” duration. Other embodiments are also described.
Owner:MEDTRONIC INC
Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
Owner:MEDTRONIC INC
Systems and methods for reversibly blocking nerve activity
InactiveUS7389145B2Reduce the amplitudeRaise the possibilityElectrotherapyChronic conditionHigh likelihood
Systems and methods for blocking nerve impulses use an implanted electrode located on or around a nerve. A specific waveform is used that causes the nerve membrane to become incapable of transmitting an action potential. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic conditions. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.
Owner:CASE WESTERN RESERVE UNIV
Techniques for applying, configuring, and coordinating nerve fiber stimulation
ActiveUS20050267542A1Decreased heart rateEliminate side effectsSpinal electrodesHeart stimulatorsCardiac arrhythmiaCarotid sinus
Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.
Owner:MEDTRONIC INC
Non-invasive treatment of bronchial constriction
ActiveUS20110046432A1Relieve spasmsDilation increaseUltrasound therapyElectrotherapyNerve fiber bundleSmooth muscle
Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and / or electrical, mechanical and / or acoustic, and optical and / or thermal energy, stimulate the selected nerve fibers.
Owner:ELECTROCORE
Apparatus and method for stimulation of nerves and automated control of surgical instruments
A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
Owner:LOCKHEED MARTIN CORP
Miniature apparatus and method for optical stimulation of nerves and other animal tissue
A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
Owner:NERVESENSE LTD
Non-invasive treatment of neurodegenerative diseases
ActiveUS20110152967A1Reduce neuroinflammationReduce inflammationElectrotherapyMagnetotherapy using coils/electromagnetsRetinoidPostoperative cognitive dysfunction
Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and / or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium. Reduction in inflammation is effected by enhancing the anti-inflammatory competence of cytokines such as TGF-beta, wherein a retinoid or components of the retinoic acid signaling system provide an anti-inflammatory bias, by enhancing anti-inflammatory activity of a neurotrophic factor such as NGF, GDNF, BDNF, or MANF, and / or by inhibiting the activity of pro-inflammatory cytokines such as TNF-alpha.
Owner:ELECTROCORE
Apparatus and method for optical stimulation of nerves and other animal tissue
A nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light-generating source is operatively coupled to an optical fiber, which in turn is coupled to a plug in the end of a holder in a sheath. Light is then passed from the light source through the optical fiber to the holder and out a selected optical tip on the sheath to provide an efficacious amount of light to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. Some embodiments omit the fiber and use light directly from the laser diode.
Owner:NERVESENSE LTD
Modular stimulator for treatment of back pain, implantable RF ablation system and methods of use
ActiveUS20110224665A1Rehabilitate spinal stabilityRestore neural driveSpinal electrodesDiagnosticsRf ablationMuscle contraction
Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and / or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.
Owner:MAINSTAY MEDICAL
Therapeutic device for pain management and vision
ActiveUS20100036488A1Increase moistureRelieve painSenses disorderEye implantsEpitheliumTherapeutic Devices
A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and / or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and / or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and / or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and / or Bowman's membrane.
Owner:NEXIS VISION LIQUIDATING TRUST +2
Method and apparatus for selective control of nerve fibers
InactiveUS20020099419A1Pain reliefReduced sensationElectrotherapyArtificial respirationFiberNerve fiber bundle
A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a "green wave" effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.
Owner:MEDTRONIC INC
Nerve-branch-specific action-potential activation,inhibition, and monitoring
A dual electrode arrangement, is provided, wherein two, preferably unidirectional, electrode configurations flank a nerve junction from which a preselected nerve branch issues, proximally and distally to the junction, with respect to the brain. The arrangement is conducive to the following: generating efferent action-potential propagations, substantially restricted to the preselected nerve branch, inhibiting afferent action-potential propagations, from the preselected nerve branch, selectively generating action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch, and selectively inhibiting action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch. The dual electrode arrangement is further conducive to monitoring naturally-occurring, efferent action-potential propagations, heading towards the preselected nerve branch, and monitoring naturally-occurring, afferent action-potential propagations, from the preselected nerve branch. The unidirectional electrode configurations may be monopolar, bipolar, tripolar, or multipolar. Communication with extracorporeal stations, and closed loop operations are also provided.
Owner:MEDTRONIC INC
Minimal device and method for effecting hyperthermia derived anesthesia
InactiveUS9031667B2Improve comfortLess chance of physical damageElectrotherapySurgical needlesFiberMammal
A method and device for inducing anaesthesia in mammals by the application of RF energy to create hyperthermia derived neural anaesthesia. An RF generator drives a plurality of electrodes placed in tissue surrounding the target nerve fiber to desiccate the desired length of nerve fiber to be desiccated in a single deployment. The device allows high-speed selection / de-selection of bipolar electrode pairs or sets under continuous RF excitation. Activation of electrode pairs is adapted in response to sensed current density and temperature (by electrodes not in the current discharge activation phase) in order to create lesions of complex and well defined shape necessary for the production of hyperthermia derived neural anaesthesia.
Owner:INTERVENTION TECH
Miniature apparatus and method for optical stimulation of nerves and other animal tissue
A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
Owner:NERVESENSE LTD
Selective nerve fiber stimulation for treating heart conditions
ActiveUS20050187586A1Modify heart rate variabilityReduce heart rate variabilitySpinal electrodesHeart stimulatorsNerve fiber bundleRR interval
Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
Owner:MEDTRONIC INC
Non-invasive magnetic or electrical nerve stimulation to treat or prevent dementia
ActiveUS20130066392A1Inhibition of excitementAvoid stimulationElectroencephalographyElectrotherapyAdrenergicMedicine
Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and / or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
Owner:ELECTROCORE
Method for controlling or regulating therapeutic nerve stimulation using electrical feedback
A stimulation system includes a stimulation source, an implantable stimulation lead, an implantable sensing device, and a controller. The stimulation source generates and transmits stimulation pulses to stimulation electrodes on the stimulation lead. The stimulation electrodes deliver the stimulation pulses to target nerve tissue in a nerve pathway to cause paresthesia in a portion of the person's body. Each stimulation pulse induces an action potential in a number of nerve fibers in the nerve pathway. The sensing device includes sensing electrodes positioned proximate the nerve pathway that detect compound action potentials of nerve fibers stimulated by the stimulation pulses. The controller modifies the stimulation pulses generated by the stimulation source and delivered to the target nerve tissue by the stimulation electrodes based on the detected compound action potentials to maintain a substantially constant level of paresthesia in the portion of the person's body.
Owner:ADVANCED NEUROMODULATION SYST INC
Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
ActiveUS20120271277A1Improve control and treatmentTime efficient and safeElectrocardiographySurgical needlesCapital equipmentLeft atrium
At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and / or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.
Owner:ABLATIVE SOLUTIONS INC
Method of biochemical treatment of persistent pain
InactiveUS20050152905A1Reduce releaseAvoid exposureBiocidePeptide/protein ingredientsInterleukin 6Interleukin-1beta
This invention relates to a method for the biochemical treatment of persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject any one of several combinations of components that are inhibitors of biochemical mediators of inflammation. Said process for biochemical treatment of persistent pain disorders is based on Sota Omoigui's Law, which states: ‘The origin of all pain is inflammation and the inflammatory response’. Sota Omoigui's Law of Pain unifies all pain syndromes as sharing a common origin of inflammation and the inflammatory response. The various biochemical mediators of inflammation are present in differing amounts in all pain syndromes and are responsible for the pain experience. Classification and treatment of pain syndromes should depend on the complex inflammatory profile. A variety of mediators are generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by nerve fibers themselves, sympathetic fibers and various immune cells. Biochemical mediators of inflammation that are targeted for inhibition include but are not limited to: prostaglandin, nitric oxide, tumor necrosis factor alpha, interleukin 1-alpha, interleukin 1-beta, interleukin-4, Interleukin-6 and interleukin-8, histamine and serotonin, substance P, Matrix Metallo-Proteinase, calcitonin gene-related peptide, vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin A, bradykinin, kallidin and T-kinin.
Owner:OMOIGUI OSEMWOTA SOTA
Method for controlling the pain from injections or minor surgical procedures and apparatus for use therewith
InactiveUS6902554B2Reducing and eliminating painReduce and eliminate painSurgeryMedical devicesFiberNerve fiber bundle
The pain associated with an injection or minor surgical procedure at a site on the skin of a patient is reduced by urging a skin engaging surface of a pressure member against the skin proximate the site, thereby stimulating the large diameter afferent sensory nerve fibers in the skin proximate the site and at least partially blocking pain signals from the small diameter afferent pain nerve fibers in the skin proximate the site. An apparatus for use in this method comprises a pressure member having a skin engaging surface adapted to be pressed against the skin of a patient proximate the site to stimulate the large diameter afferent sensory nerve fibers in the skin proximate the site. In certain embodiments, the skin engaging surface is comprised of a plurality of projections extending from the pressure member. Various embodiments include a syringe retainer adapted to be secured to a syringe, and a least one resilient member, such as a spring, resiliently securing the pressure member to the syringe retainer.
Owner:BIONIX DEVMENT
Methods and compositions for administration of TRPV1 agonists
Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.
Owner:GRT US HLDG INC
Peri-vascular tissue ablation catheter with support structures
ActiveUS8740849B1Add supportImprove uniformityHydroxy compound active ingredientsDiagnosticsVascular tissueGuide tube
An intravascular catheter for peri-vascular and / or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and / or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Owner:ABLATIVE SOLUTIONS INC
Electrical Treatment Of Bronchial Constriction
ActiveUS20090281593A9Dilation increaseFunction increaseSpinal electrodesHead electrodesNerve fiber bundleSmooth muscle
Owner:ELECTROCORE
Transvascular catheter for extravascular delivery
ActiveUS20140121641A1Reduce or eliminate patient discomfort and painReduces potential traumaBalloon catheterSurgical needlesHuman bodyPerfusion
An intravascular catheter for peri-vascular and / or peri-urethral tissue ablation includes multiple needles advanced through guide tubes which may be supported by an expandable balloon. The guide tubes expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The diameter of the inflated balloon is less than the inside diameter of the vessel, allowing perfusion across the inflated balloon and guide tubes.
Owner:ABLATIVE SOLUTIONS INC
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