113 results about "Retinoid" patented technology

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention discloses a method for biological high-density synthesis of retinaldehyde and a synthetic strain thereof. The synthetic strain is obtained by expressing ATP citrate lyase ACL, acetyl-CoA synthase ACS, choline kinase CK, inositol polyphosphate kinase IPK and vitreoscilla hemoglobin VHb in host bacteria. Wherein the host bacterium is a pichia pastoris gene modified bacterial strain PP-B2C. The retinaldehyde production performance of the recombinant strain is verified on the basis of a precursor supply pathway, an IUP pathway and a dissolved oxygen level, and the retinaldehyde production capacity of the pichia pastoris is further improved. The construction method of the recombinant pichia pastoris is simple, the synthesis of retinaldehyde can be better promoted, and the retinaldehyde can be efficiently synthesized by the engineering strain by utilizing glucose and methanol through amplification fermentation of a 5L fermentation tank, so that the recombinant pichia pastoris is beneficial to industrial production.

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

The present disclosure provides a method of producing retinol, the method comprising culturing a microorganism of the genus Yarrowia in a medium comprising a non-ionic surfactant; a method of increasing retinol production; and a method of producing retinoids.

The invention provides application of retinoic acid in preparation of a medicine for treating vascular calcification, and belongs to the technical field of medicines. The early warning and treatment effects of retinoic acid on vascular calcification are provided for the first time, a new source is provided for preparing the medicine for early warning and / or treating vascular calcification, and meanwhile the new medicinal value of retinoic acid is explored. Cardiovascular calcification and vascular smooth muscle cell calcification are relieved by supplementing retinoic acid in vivo and in vitro, and the feasibility that retinoic acid can be used as a potential medicine for treating vascular calcification is prompted. The retinoic acid content is in negative correlation with the coronary artery calcification integral of the human body and the calcification severity degree, and it is prompted that the retinoic acid content can serve as an early warning index of cardiovascular calcification and the severity degree.

Based on co-drugs representing two different chemical entities and the co- and sequential administration of the two chemical entities, novel therapies for macular degeneration and TTR amyloidosis are provided. The first component (“selective TTR ligand”) is a chemical entity that binds to TTR in the RBP4 (retinol-binding protein 4)-TTR (transthyretin) complex, which participates in the delivery of retinol to the retina. This component reduces retinol transport from circulation to the retina and provides stabilization of the TTR tetramer. The second component (“C20-D3-visual chromophore-generating compound”) is a C20-D3 modified retinoid or carotenoid that, when metabolized in mammals, ultimately produces a C20-D3 visual chromophore, which is presented in the retina as C20-D3-9-cis-retinal or C20-D3-11-cis-retinal. Deuteration at C20 reduces the formation of lipofuscin biretinol, but other functions (such as providing a precursor for the synthesis of the visual chromophore 11-cis-retinaldehyde in vivo) are not reduced.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a retinoid. The invention also relates to a method for treating the skin using said composition and to a method for enhancing the anti-aging effect of retinoids in the skin layer.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

Disclosed herein are methods of assessing changes of expression in patients' nervous systems of molecules responsive to treatments modulating nuclear receptors for retinoid X (RXR alpha, beta, or gamma), Nurr1(NR4A2) nuclear receptors, Nur77 (NR4A1) nuclear receptors, dopamine active transporter (DAT), or dopa decarboxylase (DDC), for nervous system disorders or conditions related to these molecules.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

The present application relates to a method for producing retinol comprising a step of culturing a Yarrowia microorganism in a medium containing an antioxidant, a method for increasing retinol production, a method for producing a retinoid, a medium composition for a Yarrowia microorganism for producing retinol containing an antioxidant, and a composition for producing retinol comprising the microorganism or a culture thereof and an antioxidant.

The present application generally relates to a method of treating advanced hepatic fibrosis with Formulation (I). Formulation (I) is a retinoid-conjugated lipid nanoparticle (LNP) containing HSP47 siRNA which prevents HSP47 protein translation.

The application belongs to the technical field of cosmetics and skin external preparation, and discloses a retinoid, a preparation method and application thereof. The compound is formed by covalently coupling a Schiff base or a kinin releasing enzyme cleavable peptide bond (L) and a free L-amino acid, a di- to hexapeptide or a C6-C22 fatty acid ester (P) of the retinol parent (R), and the structural general formula is R-L-P. The compound has a 12-week stability rate of ≥80% in a 25℃ aqueous preparation, is recognized by a keratin layer carboxylic acid esterase and a kinin releasing enzyme KLK-5 / KLK-7 after being applied to the skin, is subjected to enzymatic cutting in a skin acidic cuticle (pH 4.5-5.5) microenvironment, and releases free retinol at a fixed point. Compared with retinol palmitate, the in-situ release efficiency of the compound of the application is increased by 2.5-4.5 times, while the risk of systemic absorption is significantly reduced, and the incidence of sensitive skin irritation is ≤6.7%.

The present invention relates to a composition for preparing retinoid, and more specifically, the composition comprises: a NADH or NADPH, a Beta-Carotene Oxygenase and a flavodoxin or a ferredoxin or a reductase of flavodoxin or ferredoxin; or a microorganism expressing them; or a culture or pulverized product of the microorganism, and thus can expand the supply metabolism of reducing electrons to enhance retinoid productivity through an increase in the activity of the cytochrome P450 system and provide a foundation for the low-cost production of raw materials, and thereby enhance the economic feasibility and efficiency of retinoid production.

Described herein are retinoid compositions comprising (a) a retinoid preferably a C20-deuterated vitamin A that inhibits dimerisation to N-retinylidene-N-retinylethanolamine (A2E), (b) a lipid excipient preferably an omega-3 fatty acid comprising eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), and (c) a surfactant, wherein the compositions increase the bioavailability of the retinoid in a subject, and methods of using such retinoid compositions for treating eye conditions including macular degeneration.

Methods and systems for cell-free bioproduction of retinal and retinol are provided, which may be performed using a combination of a beta-carotene 15,15'-dioxygenase and an alcohol dehydrogenase. Cell-free retinoid production enables reaction rates and productivity not possible / not obtained in cell-based systems.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

The present application relates to a method for producing retinol comprising a step of culturing a Yarrowia microorganism in a medium containing a nonionic surfactant, a method for increasing retinol production, a method for producing a retinoid, a Yarrowia microorganism medium composition for producing retinol comprising a nonionic surfactant, and a composition for producing retinol comprising the microorganism or a culture thereof and a nonionic surfactant.

The present application relates to a Yarrowia microorganism that expresses Dunaliella salina-derived geranylgeranyl pyrophosphate synthase and has the ability to produce carotenoids or substances whose precursors are carotenoids, a method for producing carotenoids or substances whose precursors are carotenoids using the same, a composition for producing carotenoids or substances whose precursors are carotenoids, and use of the Yarrowia microorganism or a culture thereof for producing carotenoids or substances whose precursors are carotenoids.

An oil-in-water emulsion having an SPF of at least 25, comprising: (a) at least 0.01 wt.% of one or more types of retinol selected from the group consisting of retinol, retinaldehyde, retinoic acid, or a combination thereof; (b) one or more water soluble antioxidants; (c) one or more oil soluble antioxidants; (d) at least 10 wt.% of one or more oil soluble or oil dispersible sunscreen components. Methods of making the oil-in-water emulsions as well as uses and methods of use of the oil-in-water emulsions.

A fermentative process for producing a desired retinyl ester of a fatty acid (desired retinyl fatty acid ester) is described herein. The process generally comprises: (i) providing retinol-producing cells that express an enzyme that catalyzes the conversion of retinol to a retinyl ester; and (ii) culturing the retinol-producing cells in a production medium comprising the fatty acid and / or an alkyl ester thereof, under conditions enabling the production of the desired retinyl fatty acid ester. The production medium may further comprise a liquid alkane and / or alkene mixture, resulting in improved production and / or purity of desired retinyl fatty acid ester. Also described herein are microorganisms engineered for the production of retinoids, such as retinyl fatty acid esters.

A personal care composition comprising a carboxymethylcysteine ​​compound and a retinoid, wherein the weight ratio of the carboxymethylcysteine ​​compound to the retinoid is from 1:1.6 to 25:1, is disclosed.

The present application relates to a Yarrowia microorganism that expresses geranylgeranyl pyrophosphate synthase derived from Haematococcus pluvialis and has the ability to produce a carotenoid or a substance whose precursor is a carotenoid, a method for producing a carotenoid or a substance whose precursor is a carotenoid using the same, a composition for producing a carotenoid or a substance whose precursor is a carotenoid, and use of the Yarrowia microorganism or a culture thereof for producing a carotenoid or a substance whose precursor is a carotenoid.

Skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid are disclosed herein. In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are responsive to retinoids.

The present invention relates to a retinoid for RAR activated synthesis. The present invention relates to the use of a compound of formula I in the manufacture of a medicament for the treatment of a condition or disease ameliorated by activation of the retinoic acid receptor (RAR): wherein A1-A7 and R1 to R5 are defined herein. The invention also relates to pharmaceutical compositions comprising such compounds. Aspects of the invention relate to novel compounds of formula I, wherein A1-A7 and R1 to R5 are defined herein. # imgabs0 #

Provided is a method of producing a fermentation product, the method comprising a first step of preparing a deionized process liquid by removing ions from a process liquid comprising the fermentation product through capacitive deionization (CDI); and a second step of spray-drying the deionized process liquid to obtain the fermentation product without re-crystallization of the fermentation product.

This application relates to a Yarowia liporitica microorganism with enhanced SNQ2 protein activity and retinoid-producing ability, a method for producing retinoids using the same, a composition for retinoid production, its use in retinoid production, and a method for producing the said microorganism.

The application discloses a method for simultaneously detecting retinoids and lipid-soluble vitamin metabolic marker groups in biological samples and matching reagents. The application is based on magnetic bead solid-phase extraction technology, significantly improves sample purification effect, and reduces matrix interference; in combination with a high-aqueous-phase reversed-phase chromatography system and a positive-negative ion switching multi-reaction monitoring mode, simultaneous separation and detection of seven retinoid molecules and a full spectrum of lipid-soluble vitamins are realized. The method has high sensitivity, strong specificity and wide detection range, and for the first time realizes one-stop analysis across species and sample types, thereby providing reliable platform support for clinical and scientific research applications.

The invention relates to composition for skin care. In particular the invention relates to skincare composition comprising a myrrh resin extract, and a retinoid. The invention also relates to a method of treating the skin using said composition, and to a method for boosting the anti-aging effects of retinoids in the skin layers.