66 results about "Retinoid" patented technology

The invention discloses a method for biological high-density synthesis of retinaldehyde and a synthetic strain thereof. The synthetic strain is obtained by expressing ATP citrate lyase ACL, acetyl-CoA synthase ACS, choline kinase CK, inositol polyphosphate kinase IPK and vitreoscilla hemoglobin VHb in host bacteria. Wherein the host bacterium is a pichia pastoris gene modified bacterial strain PP-B2C. The retinaldehyde production performance of the recombinant strain is verified on the basis of a precursor supply pathway, an IUP pathway and a dissolved oxygen level, and the retinaldehyde production capacity of the pichia pastoris is further improved. The construction method of the recombinant pichia pastoris is simple, the synthesis of retinaldehyde can be better promoted, and the retinaldehyde can be efficiently synthesized by the engineering strain by utilizing glucose and methanol through amplification fermentation of a 5L fermentation tank, so that the recombinant pichia pastoris is beneficial to industrial production.

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

The invention provides application of retinoic acid in preparation of a medicine for treating vascular calcification, and belongs to the technical field of medicines. The early warning and treatment effects of retinoic acid on vascular calcification are provided for the first time, a new source is provided for preparing the medicine for early warning and / or treating vascular calcification, and meanwhile the new medicinal value of retinoic acid is explored. Cardiovascular calcification and vascular smooth muscle cell calcification are relieved by supplementing retinoic acid in vivo and in vitro, and the feasibility that retinoic acid can be used as a potential medicine for treating vascular calcification is prompted. The retinoic acid content is in negative correlation with the coronary artery calcification integral of the human body and the calcification severity degree, and it is prompted that the retinoic acid content can serve as an early warning index of cardiovascular calcification and the severity degree.

Based on co-drugs representing two different chemical entities and the co- and sequential administration of the two chemical entities, novel therapies for macular degeneration and TTR amyloidosis are provided. The first component (“selective TTR ligand”) is a chemical entity that binds to TTR in the RBP4 (retinol-binding protein 4)-TTR (transthyretin) complex, which participates in the delivery of retinol to the retina. This component reduces retinol transport from circulation to the retina and provides stabilization of the TTR tetramer. The second component (“C20-D3-visual chromophore-generating compound”) is a C20-D3 modified retinoid or carotenoid that, when metabolized in mammals, ultimately produces a C20-D3 visual chromophore, which is presented in the retina as C20-D3-9-cis-retinal or C20-D3-11-cis-retinal. Deuteration at C20 reduces the formation of lipofuscin biretinol, but other functions (such as providing a precursor for the synthesis of the visual chromophore 11-cis-retinaldehyde in vivo) are not reduced.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a retinoid. The invention also relates to a method for treating the skin using said composition and to a method for enhancing the anti-aging effect of retinoids in the skin layer.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

Disclosed herein are methods of assessing changes of expression in patients' nervous systems of molecules responsive to treatments modulating nuclear receptors for retinoid X (RXR alpha, beta, or gamma), Nurr1(NR4A2) nuclear receptors, Nur77 (NR4A1) nuclear receptors, dopamine active transporter (DAT), or dopa decarboxylase (DDC), for nervous system disorders or conditions related to these molecules.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

The application belongs to the technical field of cosmetics and skin external preparation, and discloses a retinoid, a preparation method and application thereof. The compound is formed by covalently coupling a Schiff base or a kinin releasing enzyme cleavable peptide bond (L) and a free L-amino acid, a di- to hexapeptide or a C6-C22 fatty acid ester (P) of the retinol parent (R), and the structural general formula is R-L-P. The compound has a 12-week stability rate of ≥80% in a 25℃ aqueous preparation, is recognized by a keratin layer carboxylic acid esterase and a kinin releasing enzyme KLK-5 / KLK-7 after being applied to the skin, is subjected to enzymatic cutting in a skin acidic cuticle (pH 4.5-5.5) microenvironment, and releases free retinol at a fixed point. Compared with retinol palmitate, the in-situ release efficiency of the compound of the application is increased by 2.5-4.5 times, while the risk of systemic absorption is significantly reduced, and the incidence of sensitive skin irritation is ≤6.7%.

Methods and systems for cell-free bioproduction of retinal and retinol are provided, which may be performed using a combination of a beta-carotene 15,15'-dioxygenase and an alcohol dehydrogenase. Cell-free retinoid production enables reaction rates and productivity not possible / not obtained in cell-based systems.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

An oil-in-water emulsion having an SPF of at least 25, comprising: (a) at least 0.01 wt.% of one or more types of retinol selected from the group consisting of retinol, retinaldehyde, retinoic acid, or a combination thereof; (b) one or more water soluble antioxidants; (c) one or more oil soluble antioxidants; (d) at least 10 wt.% of one or more oil soluble or oil dispersible sunscreen components. Methods of making the oil-in-water emulsions as well as uses and methods of use of the oil-in-water emulsions.

A fermentative process for producing a desired retinyl ester of a fatty acid (desired retinyl fatty acid ester) is described herein. The process generally comprises: (i) providing retinol-producing cells that express an enzyme that catalyzes the conversion of retinol to a retinyl ester; and (ii) culturing the retinol-producing cells in a production medium comprising the fatty acid and / or an alkyl ester thereof, under conditions enabling the production of the desired retinyl fatty acid ester. The production medium may further comprise a liquid alkane and / or alkene mixture, resulting in improved production and / or purity of desired retinyl fatty acid ester. Also described herein are microorganisms engineered for the production of retinoids, such as retinyl fatty acid esters.

Skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid are disclosed herein. In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

Provided is a method of producing a fermentation product, the method comprising a first step of preparing a deionized process liquid by removing ions from a process liquid comprising the fermentation product through capacitive deionization (CDI); and a second step of spray-drying the deionized process liquid to obtain the fermentation product without re-crystallization of the fermentation product.

This application relates to a Yarowia liporitica microorganism with enhanced SNQ2 protein activity and retinoid-producing ability, a method for producing retinoids using the same, a composition for retinoid production, its use in retinoid production, and a method for producing the said microorganism.

The application discloses a method for simultaneously detecting retinoids and lipid-soluble vitamin metabolic marker groups in biological samples and matching reagents. The application is based on magnetic bead solid-phase extraction technology, significantly improves sample purification effect, and reduces matrix interference; in combination with a high-aqueous-phase reversed-phase chromatography system and a positive-negative ion switching multi-reaction monitoring mode, simultaneous separation and detection of seven retinoid molecules and a full spectrum of lipid-soluble vitamins are realized. The method has high sensitivity, strong specificity and wide detection range, and for the first time realizes one-stop analysis across species and sample types, thereby providing reliable platform support for clinical and scientific research applications.

The present invention relates to eutectics wherein one of the components is a retinoid and the other is a hydrogen bond acceptor or a hydrogen bond donor. In such eutectics the retinoid is stabilized against its degradation caused by temperature, pH and / or exposure to light.

Disclosed herein are compositions suitable for use in food, feed, pharmaceutical, and cosmetic products, comprising a retinoid component and its fermentation residue. In one embodiment, the retinoid component is present in a weight ratio to the fermentation residue of 4:1 or greater, the retinoid contains cis- and trans-isomers, and the cis-isomer is present in an amount of less than 3% by weight of the total isomer mixture. Preferably, the composition is biobased. Biotechnology methods for producing the compositions described elsewhere are also described, as well as additional methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, food, feed, pharmaceutical, and cosmetic products incorporating the compositions described herein are also disclosed.

This present disclosure provides various diamine centered poly(amino acid)-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers. In one aspect, the present disclosure provides a conjugate having the structural formula wherein B is a residue of a compound having three or four available binding positions, e.g., an alkylene diamine; S is a saccharide, for example, a residue of a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is a lipophilic carrier residue selected from fatty acid residues (for example, residues of lauric acid, myristic acid, linoleic acid, palmitic acid, oleic acid and elaidic acid), steroid acid and sterol residues, and residues of retinoids carotenoids, tocopherols, and tocotrienols; Q is a residue of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol or hexaethylene glycol; P is a residue of a polyaminoacid homopolymer; R2 is a terminal group selected from H, methyl, ethyl and maleimide; D is a secondary group that is as defined above for L or is a methyl-capped poly(ethylene glycol) residue; and d is 0, or d is 1.

The present disclosure relates to: a microorganism of Yarrowia lipolytica having an enhanced SNQ2 protein activity and having a retinoid-producing ability; a method for producing a retinoid using the same; a composition for the production of a retinoid; a use for the production of retinoid; and a method for preparing the microorganism.

Based on co-drugs representing two different chemical entities and the co- and sequential administration of the two chemical entities, novel therapies for macular degeneration and TTR amyloidosis are provided. The first component (“Bispecific RBP4 / TTR ligand”) is a chemical entity that binds to both TTR and RBP4 in the RBP4 (retinol-binding protein 4)-TTR (transthyretin) complex, which participates in the delivery of retinol to the retina. This component reduces retinol transport from circulation to the retina and provides stabilization of the TTR tetramer. The second component (“C20-D3-visual chromophore-generating compound”) is a C20-D3 modified retinoid or carotenoid that, when metabolized in mammals, ultimately produces a C20-D3 visual chromophore, which is presented in the retina as C20-D3-9-cis-retinal or C20-D3-11-cis-retinal. Deuteration at C20 reduces the formation of lipofuscin biretinol, but other functions (such as providing a precursor for the synthesis of the visual chromophore 11-cis-retinaldehyde in vivo) are not reduced.

The present application relates to: a Yarrowia sp. microorganism with retinoid production ability, in which the activity of the PHO84 protein is increased compared to the endogenous activity thereof; a retinoid production method using same; a method for producing a Yarrowia sp. microorganism with retinoid production ability; and a composition for producing a retinoid.

This application relates to a microbial oil composition containing retinoids and fatty acids, a cosmetic composition, a food composition, a feed composition containing the same, and a method for producing the same.

Described herein are personal care compositions, such as skin care exfoliating agents. According to certain aspects, there is provided a personal care composition comprising a retinoid, a beta-hydroxy acid, and / or a salt thereof; and terpenes are mixed; optionally, wherein the personal care composition is substantially free or free of resorcinol and / or hydroquinone.

Stable dispersion composition comprising a retinoid. Technical field: The present invention relates to a dispersion composition comprising a continuous phase and a plurality of dispersed phases, comprising: (a) at least one retinoid and (b) at least one compound capable of providing a solution of the retinoid with a transmittance of 10% or less, preferably 5% or less and, even better, 2% or less, for light with a wavelength of 290 to 420 nm, along a 10 mm optical path length, the concentration of the compound in the solution being 0.9% by weight relative to the total weight of the solution; (c) at least one hydrophilic antioxidant other than ingredient (b) and (d) at least one cationic polymer. Figure for abstract: none

Cosmetic compositions having retinoid stability may comprise about 70 wt% to about 85 wt% of at least one emollient, based on total mass, and up to about 0.3 wt% of at least one retinoid, based on total mass. Suitable emollients may include, for example, at least glyceryl triacetyl ricinoleate, bis-diglyceryl polyacyladipate-2, hydrogenated polyisobutene, synthetic beeswax, and diisostearyl malate. The at least one retinoid may comprise hydroxypinacolone retinoate.

The object of the present invention is to provide a novel lipid composition for delivering payloads to extracellular matrix-producing cells such as fibroblasts, and a method of delivering payloads to extracellular matrix-producing cells using the above lipid composition. The present invention provides a lipid composition which comprises a payload, an ionizable lipid, a retinoid, a phospholipid, a sterol, and a polymer-conjugated lipid, and does not comprise a constitutively cationic lipid.

The present invention relates to a cosmetic composition containing a high concentration of retinoid to improve wrinkled skin, and more specifically, relates to a cholesteric liquid crystal cosmetic composition containing retinol, the composition having an excellent wrinkle-improving effect by containing a high concentration of retinoid while also being significantly less irritating to the skin.