138 results about "Retinoid" patented technology

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention discloses application of atypical retinoid A-7 in preparation of androgen receptor inhibitors and antitumor drugs, and belongs to the technical field of medicines. It is proved for the first time that AR can be degraded through a CMA pathway, and the atypical retinoid A-7 serving as an AR inhibitor can obviously reduce the AR protein level in prostate cancer cells; in addition, the Atypic retinoids 7 can be used for inhibiting the growth and proliferation capacity of the prostate cancer cells LNCaP; in addition, the invention further provides an anti-tumor medicine composition, the anti-tumor medicine composition comprises the Atypic retinoid-7 and Enzalutamide, and the anti-tumor medicine composition can be used for treating the prostatic cancer and has important clinical significance.

The invention discloses a method for biological high-density synthesis of retinaldehyde and a synthetic strain thereof. The synthetic strain is obtained by expressing ATP citrate lyase ACL, acetyl-CoA synthase ACS, choline kinase CK, inositol polyphosphate kinase IPK and vitreoscilla hemoglobin VHb in host bacteria. Wherein the host bacterium is a pichia pastoris gene modified bacterial strain PP-B2C. The retinaldehyde production performance of the recombinant strain is verified on the basis of a precursor supply pathway, an IUP pathway and a dissolved oxygen level, and the retinaldehyde production capacity of the pichia pastoris is further improved. The construction method of the recombinant pichia pastoris is simple, the synthesis of retinaldehyde can be better promoted, and the retinaldehyde can be efficiently synthesized by the engineering strain by utilizing glucose and methanol through amplification fermentation of a 5L fermentation tank, so that the recombinant pichia pastoris is beneficial to industrial production.

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

The present disclosure provides a method of producing retinol, the method comprising culturing a microorganism of the genus Yarrowia in a medium comprising a non-ionic surfactant; a method of increasing retinol production; and a method of producing retinoids.

The invention discloses a novel antibacterial application of a retinoid compound, and particularly provides an application of the retinoid compound or a pharmaceutically acceptable form of the retinoid compound in preparation of a medicine for preventing or treating infection caused by mycobacteria or diseases related to the mycobacteria or a mycobacteria inhibitor, the retinoid compound contains an adamantane structure. Experiments prove that the compound can obviously inhibit the growth of mycobacteria, so that the compound can be used for preparing medicines in the antibacterial field.

The present disclosure provides esters of a retinoid and bakuchiol, such as esters of Formula (I′). The present disclosure also provides compositions and kits comprising the esters, methods of producing the esters, methods of using the esters (e.g., for treating or preventing a skin disease, slowing the ageing of the skin, improving the appearance of the skin, or modulating a retinoid receptor).

The invention provides application of retinoic acid in preparation of a medicine for treating vascular calcification, and belongs to the technical field of medicines. The early warning and treatment effects of retinoic acid on vascular calcification are provided for the first time, a new source is provided for preparing the medicine for early warning and / or treating vascular calcification, and meanwhile the new medicinal value of retinoic acid is explored. Cardiovascular calcification and vascular smooth muscle cell calcification are relieved by supplementing retinoic acid in vivo and in vitro, and the feasibility that retinoic acid can be used as a potential medicine for treating vascular calcification is prompted. The retinoic acid content is in negative correlation with the coronary artery calcification integral of the human body and the calcification severity degree, and it is prompted that the retinoic acid content can serve as an early warning index of cardiovascular calcification and the severity degree.

Based on co-drugs representing two different chemical entities and the co- and sequential administration of the two chemical entities, novel therapies for macular degeneration and TTR amyloidosis are provided. The first component (“selective TTR ligand”) is a chemical entity that binds to TTR in the RBP4 (retinol-binding protein 4)-TTR (transthyretin) complex, which participates in the delivery of retinol to the retina. This component reduces retinol transport from circulation to the retina and provides stabilization of the TTR tetramer. The second component (“C20-D3-visual chromophore-generating compound”) is a C20-D3 modified retinoid or carotenoid that, when metabolized in mammals, ultimately produces a C20-D3 visual chromophore, which is presented in the retina as C20-D3-9-cis-retinal or C20-D3-11-cis-retinal. Deuteration at C20 reduces the formation of lipofuscin biretinol, but other functions (such as providing a precursor for the synthesis of the visual chromophore 11-cis-retinaldehyde in vivo) are not reduced.

The invention relates to a composition for skin care. In particular, the present invention relates to a skin care composition comprising a myrrh resin extract and a retinoid. The invention also relates to a method for treating the skin using said composition and to a method for enhancing the anti-aging effect of retinoids in the skin layer.

Retinol-based composition. The present invention relates to a composition, particularly a cosmetic one, especially for makeup and / or the treatment of keratinous materials, comprising at least one retinoid, in particular retinol; bisabolol; 4-t-butylcyclohexanol; niacinamide; and D-panthenol. Figure for the abstract: None

Disclosed herein are methods of assessing changes of expression in patients' nervous systems of molecules responsive to treatments modulating nuclear receptors for retinoid X (RXR alpha, beta, or gamma), Nurr1(NR4A2) nuclear receptors, Nur77 (NR4A1) nuclear receptors, dopamine active transporter (DAT), or dopa decarboxylase (DDC), for nervous system disorders or conditions related to these molecules.

New therapies for macular degeneration and TTR amyloidosis are provided based on a co-drug that represents a conjugate of two distinct chemical entities as well as co- administration and sequential administration of the two chemical entities. The first component ("bispecific RBP4 / TTR ligand") is a chemical entity that engages TTR ( transthyretin) and RBP4 ( retinol binding protein 4 ) of the RBP4 -TTR complex, which is involved in delivery of retinol to the retina. This component reduces traffic of retinol from circulation to the retina and provides stabilization of TTR tetramers. The second component ("C20-D3-visual-chromophore-producing compound" ) is a C20 -D3 -modified retinoid or carotenoid that upon metabolism in a mammal can eventually produce a C20-D3 visual chromophore that represents C20 -D3- 9-cis-retinaldehyde or C20-D3-11-cis-retinaldehyde in the retina. Deuteration at the C20 position reduces the formation of lipofuscin bisretinoid while other functions ( such as providing a precursor for in vivo synthesis of the visual chromophore, 11-cis-retinaldehyde ) are not reduced.

The present invention relates to methods of treating atrial fibrillation or preventing or reversing atrial remodeling, comprising administering a retinoid, such as all-trans retinoic acid (ATRA).

A composition for a krill-powder-based skin care product and a method of use thereof rejuvenates the skin and helps maintain a healthy skin and a healthy integumentary system. The composition includes a quantity of krill powder, a quantity of hyaluronic-acid powder, a quantity of calcium-benzoate clay powder, a quantity of aloe-vera powder, a quantity of vitamin-A palmitate powder, and a quantity of colloidal silver. The quantity of krill powder, the quantity of hyaluronic-acid powder, the quantity of calcium-benzoate clay powder, the quantity of aloe-vera powder, the quantity of vitamin-A palmitate powder, and the quantity of colloidal silver are homogeneously mixed into a final powder compound that is non-hydrated. The final powder compound can be rehydrated at the time of application to increase the shelf life of the composition. Further, the composition can be infused together with potential additional ingredients such as retinoid, gelatin, and liquid solvents.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

The present application relates to a method for producing retinol comprising a step of culturing a Yarrowia microorganism in a medium containing an antioxidant, a method for increasing retinol production, a method for producing a retinoid, a medium composition for a Yarrowia microorganism for producing retinol containing an antioxidant, and a composition for producing retinol comprising the microorganism or a culture thereof and an antioxidant.

The present application generally relates to a method of treating advanced hepatic fibrosis with Formulation (I). Formulation (I) is a retinoid-conjugated lipid nanoparticle (LNP) containing HSP47 siRNA which prevents HSP47 protein translation.

The application belongs to the technical field of cosmetics and skin external preparation, and discloses a retinoid, a preparation method and application thereof. The compound is formed by covalently coupling a Schiff base or a kinin releasing enzyme cleavable peptide bond (L) and a free L-amino acid, a di- to hexapeptide or a C6-C22 fatty acid ester (P) of the retinol parent (R), and the structural general formula is R-L-P. The compound has a 12-week stability rate of ≥80% in a 25℃ aqueous preparation, is recognized by a keratin layer carboxylic acid esterase and a kinin releasing enzyme KLK-5 / KLK-7 after being applied to the skin, is subjected to enzymatic cutting in a skin acidic cuticle (pH 4.5-5.5) microenvironment, and releases free retinol at a fixed point. Compared with retinol palmitate, the in-situ release efficiency of the compound of the application is increased by 2.5-4.5 times, while the risk of systemic absorption is significantly reduced, and the incidence of sensitive skin irritation is ≤6.7%.

The present invention relates to a composition for preparing retinoid, and more specifically, the composition comprises: a NADH or NADPH, a Beta-Carotene Oxygenase and a flavodoxin or a ferredoxin or a reductase of flavodoxin or ferredoxin; or a microorganism expressing them; or a culture or pulverized product of the microorganism, and thus can expand the supply metabolism of reducing electrons to enhance retinoid productivity through an increase in the activity of the cytochrome P450 system and provide a foundation for the low-cost production of raw materials, and thereby enhance the economic feasibility and efficiency of retinoid production.

The present disclosure relates to a composition for increasing the efficacy of a retinoid by comprising a retinoid and a material for increasing the efficacy of a retinoid, i.e., a retinoid enhancer. The composition for improving skin wrinkles according to the present disclosure can significantly improve the skin wrinkle improving effect of retinoid by inhibiting a mechanism of oxidative decomposition of retinoic acid by a CYP family enzyme through a specific retinoid enhancer compound.

Described herein are retinoid compositions comprising (a) a retinoid preferably a C20-deuterated vitamin A that inhibits dimerisation to N-retinylidene-N-retinylethanolamine (A2E), (b) a lipid excipient preferably an omega-3 fatty acid comprising eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), and (c) a surfactant, wherein the compositions increase the bioavailability of the retinoid in a subject, and methods of using such retinoid compositions for treating eye conditions including macular degeneration.

Methods and systems for cell-free bioproduction of retinal and retinol are provided, which may be performed using a combination of a beta-carotene 15,15'-dioxygenase and an alcohol dehydrogenase. Cell-free retinoid production enables reaction rates and productivity not possible / not obtained in cell-based systems.

Retinoids in cosmetic compositions can degrade over time, thereby diminishing the effectiveness of cosmetic compositions. The present disclosure includes cosmetic compositions that exhibit enhanced retinoid stability. Also disclosed are methods of improving the stability of retinoids in cosmetic compositions. Additives can be used, either alone or in combination, to improve retinoid stability and increase retinoid-containing cosmetic composition shelf life.

The present application relates to a method for producing retinol comprising a step of culturing a Yarrowia microorganism in a medium containing a nonionic surfactant, a method for increasing retinol production, a method for producing a retinoid, a Yarrowia microorganism medium composition for producing retinol comprising a nonionic surfactant, and a composition for producing retinol comprising the microorganism or a culture thereof and a nonionic surfactant.

Provided are a method of producing retinol, the method comprising the step of culturing a microorganism of the genus Yarrowia in a medium comprising a non-ionic surfactant; a method of increasing retinol production; a method of producing retinoids; a medium composition for a microorganism of the genus Yarrowia for producing retinol, the composition comprising a non-ionic surfactant; a composition for producing retinol, the composition comprising the microorganism or a culture thereof and a non-ionic surfactant.

The present application relates to a Yarrowia microorganism that expresses Dunaliella salina-derived geranylgeranyl pyrophosphate synthase and has the ability to produce carotenoids or substances whose precursors are carotenoids, a method for producing carotenoids or substances whose precursors are carotenoids using the same, a composition for producing carotenoids or substances whose precursors are carotenoids, and use of the Yarrowia microorganism or a culture thereof for producing carotenoids or substances whose precursors are carotenoids.

The invention discloses a retinoid composition capable of reducing irritation and resisting aging and application thereof, and belongs to the technical field of preparations for dressing and makeup. The irritation-reducing and anti-aging retinoid composition comprises an anti-aging component and ginsenoside CK, the anti-aging component comprises at least one of retinol and a retinol derivative, and the mass ratio of the anti-aging component to the ginsenoside CK is 1: (0.001-2). The retinoid composition disclosed by the invention has the effects of being small in irritation and synergistically promoting aging resistance. According to the invention, the verbascos exosome is further compounded with a retinoid composition, and the retinoid composition enters the exosome through ultrasonic treatment and incubation so as to enable vesicles to wrap the composition, so that the activity of the composition can be protected, the irritation is further reduced, and the anti-aging effect is improved. Therefore, the retinoid composition provided by the invention is suitable for daily cosmetics.

An oil-in-water emulsion having an SPF of at least 25, comprising: (a) at least 0.01 wt.% of one or more types of retinol selected from the group consisting of retinol, retinaldehyde, retinoic acid, or a combination thereof; (b) one or more water soluble antioxidants; (c) one or more oil soluble antioxidants; (d) at least 10 wt.% of one or more oil soluble or oil dispersible sunscreen components. Methods of making the oil-in-water emulsions as well as uses and methods of use of the oil-in-water emulsions.

A fermentative process for producing a desired retinyl ester of a fatty acid (desired retinyl fatty acid ester) is described herein. The process generally comprises: (i) providing retinol-producing cells that express an enzyme that catalyzes the conversion of retinol to a retinyl ester; and (ii) culturing the retinol-producing cells in a production medium comprising the fatty acid and / or an alkyl ester thereof, under conditions enabling the production of the desired retinyl fatty acid ester. The production medium may further comprise a liquid alkane and / or alkene mixture, resulting in improved production and / or purity of desired retinyl fatty acid ester. Also described herein are microorganisms engineered for the production of retinoids, such as retinyl fatty acid esters.