564 results about "Choline" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a composition for improving obesity and promoting cardiovascular health as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 5 to 20 parts of glycine betaine, 1 to 5.5 parts of choline chloride, 0.5 to 4 parts of L-theanine, 1 to 15 parts of alpha-ketoglutarate calcium, 0.5 to 3 parts of black ginger extract, 0.05 to 0.25 part of black pepper extract, 0.5 to 3 parts of ginkgo leaf extract and 1 to 6 parts of black garlic juice powder. According to the invention, the eight components are selected and are scientifically combined in an optimal quantity ratio range, and the prepared composition can better reduce the inflammation level of a body, regulate abnormal blood fat, improve the lipid metabolism disorder state and effectively reduce impulsive diet behaviors, so that comprehensive improvement of obesity and cardiovascular related risks is realized, and the health-care effect of a human body is improved. The body is effectively assisted to maintain metabolic health.

The invention relates to the technical field of biological pharmacy, and discloses a QS-21 saponin adjuvant as well as a preparation method and application thereof, the adjuvant is a composite liposome and comprises a liposome skeleton composed of distearoyl phosphatidylcholine and cholesterol, and QS-21 saponin, monophosphoryl lipid A and a local anesthetic are jointly entrapped in the liposome skeleton. The problem that high reactogenicity and immunogenicity of potent adjuvants are difficult to consider at the same time is solved, the immunostimulation component and the pain inhibition component are jointly entrapped in the same nano-carrier, collaborative delivery in injection local is achieved, and therefore pain and swelling caused by the adjuvants are accurately inhibited. The co-entrapment structure avoids the potential inhibition effect of the free anesthetic on the immune system, the potent body fluid and cellular immune enhancement activity of the adjuvant is completely reserved, and a new technical scheme is provided for developing vaccines with high safety and strong immune efficacy.

The invention discloses a compound environment-friendly corrosion inhibitor as well as a preparation method and application thereof. The choline ionic liquid comprises choline ionic liquid and amino acid, the choline ionic liquid is choline cations; the amino acid is one or more of cysteine and tryptophan. The compound environment-friendly corrosion inhibitor has high corrosion inhibition efficiency, and the compound structure of the compound environment-friendly corrosion inhibitor further improves the protection performance of the compound environment-friendly corrosion inhibitor through a dual adsorption mechanism of the synergistic effect of physical adsorption and chemical adsorption on the metal surface. According to the compound environment-friendly corrosion inhibitor, a full-green ionic liquid corrosion inhibition system is constructed, the environment-friendly requirement is met, and a metal protection solution can be provided for industrial acid pickling and other strong acid working conditions. Not only is the progress of a corrosion inhibition technology promoted, but also more economic and environment-friendly anti-corrosion application can be provided for actual industrial scenes.

The application belongs to the technical field of deep eutectic solvents, and particularly relates to a ternary deep eutectic solvent and preparation and application thereof. The ternary deep eutectic solvent is composed of choline chloride, 5-sulfosalicylic acid and gamma valerolactone according to a molar ratio of 1:4:(3-25). The strong hydrogen bond network structure between the green solvent system first destroys the ester bond between lignin and hemicellulose, then cuts off the beta-O-4 bond between lignin molecules, so as to separate lignin. Meanwhile, the deep eutectic solvent can improve the stability of carbon cations due to the conjugation effect between the lone pair electrons on the heteroatom oxygen and the central carbon in the molecular structure of gamma valerolactone, so as to inhibit the condensation reaction of lignin.

The invention discloses a method for synthesizing eutectic gel by in-situ extraction of lignin, and belongs to the technical field of gel materials.The method comprises the steps that choline chloride and acrylic acid are mixed, heated in an oil bath and stirred, and a eutectic solvent is obtained; cooling the solvent, adding dried and crushed wood powder, heating in an oil bath, extracting to obtain a mixed solution, and centrifuging to obtain supernate; adding a cross-linking agent and an initiator into the supernate, heating, stirring, and cooling to room temperature to obtain a pre-polymerized solution; and pouring the pre-polymerized liquid into a polytetrafluoroethylene mold, and carrying out ultraviolet curing to obtain the target gel. According to the method, the natural structure and active groups of the lignin are reserved to the maximum extent, the method is low-carbon, energy-saving, green and sustainable, in-situ lignin and a polymerization network cooperate, the gel is endowed with higher mechanical strength, environmental stability and functional diversity, and the limitation of existing lignin doped gel is broken through.

The invention relates to the technical field of microbial fermentation, in particular to a fermentation medium for producing oxytetracycline. According to the fermentation culture medium, a corn starch-molasses-wheat hydrolyzed sugar composite carbon source, a soybean cake powder-corn steep liquor-yeast extract composite nitrogen source and a choline chloride-betaine-L-lysine precursor accelerant in a specific proportion are used as a core innovative system, and a form regulating agent, a defoaming agent and inorganic salt are cooperatively added. Through the synergistic effect of multiple components, the fermentation titer and yield of oxytetracycline are remarkably improved, the fermentation period is shortened, the generation of heteroacid is effectively inhibited, the mycelium form is optimized, and the oxytetracycline fermentation medium is suitable for industrial large-scale production of oxytetracycline.

The invention discloses a method for efficiently preparing high-activity hericium erinaceus polysaccharide from waste in the edible mushroom industry, and belongs to the technical field of deep processing of edible mushrooms and recycling of waste. The method comprises the following steps: carrying out steam explosion pretreatment on hericium erinaceus waste mushroom residues, and carrying out synergistic compatibility on the hericium erinaceus waste mushroom residues, tea residues, bean residues and citrus residues which are subjected to specific enzymolysis to prepare a liquid fermentation culture medium; a two-stage control strategy is adopted for submerged fermentation of hericium erinaceus liquid, and hypha proliferation and polysaccharide synthesis conditions are optimized; and after fermentation is finished, extracting and purifying mycelium polysaccharide by adopting a choline chloride-lactic acid eutectic solvent system. According to the method, high-valued utilization of the edible fungus chaff and various agricultural byproducts is achieved, the content of beta-(1-> 3)-D-glucan in the prepared hericium erinaceus polysaccharide is larger than or equal to 55%, the immunocompetence (IC50) reaches 32 micrograms / mL, the hericium erinaceus polysaccharide is remarkably superior to commercially available products, and the hericium erinaceus polysaccharide can be directly used as functional food and medicine raw materials. The process is green and efficient, and has remarkable economic and environmental benefits.

The invention provides a multilayer lutein ester liposome as well as a preparation method and application thereof, and belongs to the field of food processing. The multi-layer lutein ester liposome is prepared from the following raw materials: 30 to 50 parts of lutein ester, 40 to 60 parts of soybean phosphatidylcholine, 5 to 20 parts of cholesterol, 10 to 25 parts of starch sodium octenylsuccinate, 20 to 40 parts of trehalose, 15 to 30 parts of mannitol, 4 to 10 parts of phosphatidyl glycerol, 1 to 2 parts of vitamin E acetate and 1 to 2 parts of ascorbyl palmitate. According to the present invention, through the specific food-grade raw material composition and the accurate ratio relationship, the comprehensive delivery system is constructed for the highly hydrophobic and unstable lutein ester, and the system synchronously achieves the high encapsulation efficiency, the excellent stability, the good water dispersibility and the slow release function.

The invention relates to the technical field of medical protection materials, and discloses an anti-allergy skin-friendly operating kit and a preparation technology, and the composite material of the operating kit comprises the following components by mass: 40-70 parts of cellulose-based non-woven fabric; 1 to 10 parts of polymethacryloyloxyethyl phosphorylcholine which is covalently grafted to the cellulose-based non-woven fabric; 20 to 50 parts of polylactic acid-quaternary ammonium salt copolymer; 5 to 15 parts of a polyurethane hot melt adhesive; the method comprises the following steps: grafting a PMPC molecular brush on the surface of a cellulose-based non-woven fabric to obtain a skin-friendly layer; carrying out coaxial electrostatic spinning and solvent treatment on the polylactic acid-quaternary ammonium salt copolymer to prepare a hollow nanofiber barrier layer; and finally hot-pressing and compounding the two layers through a polyurethane hot-melt adhesive. According to the invention, allergy is solved through surface grafting; the toxicity is avoided by using an intrinsic antibacterial polymer; the hollow fibers and the net film are compounded, so that the contradiction between water resistance and breathability is overcome, and the biological safety and comfort of the material are improved.

The invention discloses a chlorphenesin coupling crystallization-adsorption purification method based on a deep eutectic solvent, and belongs to the technical field of chemical purification. According to the technical scheme, the method comprises the following steps: S1, mixing crude chlorphenesin with supercritical CO2, and extracting to obtain pretreated chlorphenesin; s2, dissolving the pretreated chlorphenesin in a choline chloride-glycerol DES system, adding an adsorbent after sufficient dissolution, cooling, and separating out chlorphenesin. The technical problems that an organic solvent is used in an existing chlorphenesin purification method, and the solvent is inflammable, toxic, large in dosage, long in purification time and high in energy consumption are solved, and the chlorphenesin coupling crystallization-adsorption purification method based on the eutectic solvent is safe, environmentally friendly, capable of improving production efficiency and high in product purity and yield.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The invention belongs to the technical field of plant active component extraction and purification, and particularly provides a plant extract purification method based on a deep-eutectic solvent. A plant extract purification method based on a deep-eutectic solvent comprises the following steps: firstly, crushing and grinding a plant to be extracted to obtain fine powder, then heating and uniformly mixing choline chloride, modified amino acid and lewis acid to prepare the deep-eutectic solvent, then mixing the fine powder, the deep-eutectic solvent and water according to a certain solid-to-liquid ratio, and uniformly mixing to obtain the plant extract based on the deep-eutectic solvent. And carrying out ultrasonic extraction at a certain temperature to obtain an extracting solution, and finally purifying. According to the method, the saponin component in the soapberry can be effectively extracted, the saponin yield is high, and the purity is high.

The utility model relates to the technical field of choline chloride production, and discloses a vibrating screen for choline chloride powder production, which comprises a screening box body, a feeding pipe is fixedly mounted on the wall surface of the top end of the screening box body in a penetrating manner, and a screening assembly for screening choline chloride powder is arranged in the screening box body. The screening assembly comprises a screening frame and a screening plate, a driving mechanism used for vibrating the screening frame and the screening plate is arranged on the inner wall of the rear end of the screening box body and comprises a driving motor, a driving rod and a cam, grooves are formed in the top end wall faces of the left side and the right side of the screening plate correspondingly, and positioning plates are fixedly installed in the two grooves correspondingly. Through the arrangement of the screening frame, the screening plate, the vertical rods and the first pressure springs, the screening frame and the screening plate ceaselessly bounce up and down and conduct vibration screening on raw materials, through the arrangement of the clamping mechanisms, the screening frame and the screening plate are convenient to disassemble, and therefore follow-up cleaning work can be conveniently conducted on the screening plate.

The invention provides a stepped directional extraction method of fucoidan, and relates to the technical field of extraction of active ingredients of algae. The method comprises the following steps: pretreating brown algae powder by microwaves and ultrasonic waves, mixing the pretreated brown algae powder with a deep eutectic solvent, and carrying out ultrasonic extraction to obtain algin; the eutectic solvent is composed of choline chloride and lactic acid according to the molar ratio of 1: (1-3). According to the method disclosed by the invention, a microwave-ultrasonic synergistic wall-breaking coupling deep-eutectic solvent extraction process is adopted, so that the yield of algin is increased to 73.2%, meanwhile, an additional toxic chemical chelating agent does not need to be added, the effect of effectively adsorbing heavy metal ions is achieved, and the biological safety and commercial value of the product are greatly improved.

The application provides a candidate drug for promoting embryo implantation efficiency of patients with uterine redox imbalance type RIF, and belongs to the technical field of embryo implantation. In order to solve the problem of how to find potential intervention drugs for the pathological mechanism of uterine redox imbalance type RIF, a five-step high-efficiency drug screening strategy based on an in-vitro implantation model of uterine redox imbalance type repeated embryo implantation failure is adopted to ensure the reliability and functional correlation of the screening results. The candidate drug screened by the five-step high-efficiency drug screening strategy includes any one of the following drugs: avobenzone, vasopressin, ethylenediaminetetraacetic acid dipotassium, larotrectinib sulfate, citicoline, opicapone, iclapa, L-leucine, fulvestrant, malic acid and lucotinib. Among these candidate drugs, avobenzone, vasopressin and ethylenediaminetetraacetic acid dipotassium are the best three drugs for promoting the implantation efficiency of patients with uterine redox imbalance type RIF.

This invention relates to the field of biopharmaceutical technology, disclosing a QS-21 saponin adjuvant, its preparation method, and its applications. The adjuvant is a composite liposome comprising a liposome backbone composed of distearate phosphatidylcholine and cholesterol, with QS-21 saponin, monophosphatidyllipid A, and a local anesthetic co-encapsulated therein. This invention solves the common problem of high reactivity and immunogenicity in potent adjuvants by co-encapsulating immunostimulatory and analgesic components on the same nanocarrier, achieving synergistic delivery at the injection site, thereby precisely inhibiting adjuvant-induced pain and swelling. This co-encapsulation structure avoids the potential inhibitory effect of free anesthetics on the immune system, fully preserving the adjuvant's potent humoral and cellular immune-enhancing activity. This invention provides a new technical solution for developing vaccines with both high safety and strong immunogenicity.

The invention relates to a pharmaceutical composition consisting of a liposomal formulation of a phospholipid component and an aqueous phase, wherein the phospholipid component is selected from the group consisting of phosphatidylcholine, and sphingomyelin, and wherein the phospholipid component comprises a saturated or mono-unsaturated (Z / cis) fatty acid having 14 to 20 carbon atoms. The invention further relates to the use of the pharmaceutical composition in treatment of a condition associated with presence of lipopolysaccharide (LPS), particularly endotoxemia.

The present application belongs to the technical field of fruit by-product processing, and particularly relates to a method for extracting cellulose, pectin and polyphenol from pear by-product. The present application utilizes the thermo-mechanical-chemical effect of steam explosion to treat the pear by-product through steam explosion, so that most of hemicellulose and lignin can be removed, and the cellulose, pectin and polyphenol can be efficiently and rapidly extracted, thereby shortening the production cycle of the cellulose, pectin and polyphenol and improving the efficiency. Furthermore, the present application uses a combination of choline chloride and ethanol as a low eutectic solvent, and compared with other types of hydrogen bond acceptors and hydrogen bond donors, the polyphenol extraction effect is the most significant. The present application provides a method for laying a foundation for further development and utilization of pear residue cellulose, pectin and polyphenol, and improves the comprehensive utilization rate of pear processing by-products.

The invention discloses an application of isothunberine or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating asthma diseases. It is found that in an OVA-induced mouse asthma model, the isothunberine significantly reduces airway resistance excited by acetylcholine, improves inflammatory cell infiltration and airway mucus high secretion of asthma model mouse lung tissue, reduces the levels of lgE and OVA-lgE in serum and related inflammatory factors in alveolar lavage fluid, and has the effect of preventing and treating asthma. Therefore, the effect of treating asthma is achieved. Therefore, the isothunberine has the potential of preventing or treating the asthma, provides a new treatment mode for the treatment of the asthma, and has a wide application prospect.

The invention relates to the technical field of agricultural product processing, in particular to a preparation method and application of high-activity medicinal and edible lily tea drink dried flowers. The method solves the problem that active ingredients such as flavonoids, aromatics, steroid saponins and alkaloids are easy to lose in the existing dried lily preparation. In the prepared dried medical lily flowers, the relative concentration of honeysuckle glycoside is larger than or equal to 1460 micrograms / g, the relative concentration of benzene and substituted derivatives thereof is larger than or equal to 960 micrograms / g, the relative concentration of steroid sapogenin-O-glucose is larger than or equal to 2120 micrograms / g, the relative concentration of choline is larger than or equal to 699 micrograms / g, the medical value and edible quality of the dried medical lily flowers are remarkably improved, and the method is suitable for large-scale production.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a preparation method of a traditional Chinese medicine external preparation for arthralgia based on blood circulation promoting and blood stasis removing, which comprises the following steps: extracting ferulic acid from angelica sinensis and ligusticum wallichii by adopting a supercritical CO2 fluid extraction process; extracting safflower, frankincense and other medicinal materials to obtain a synergistic active ingredient extract; the ferulic acid is used as a first hydrogen bond donor to react with lauric acid used as a temperature-sensitive phase change hydrogen bond donor and choline chloride used as a hydrogen bond acceptor, and the temperature-sensitive bioactive ternary eutectic solvent is prepared; loading the synergistic active ingredient extract in the solvent at low temperature to form a medicine mother solution; and finally, mixing the medicine mother liquor with auxiliary materials to prepare the external preparation. Ferulic acid in medicinal materials serves as a structural unit of a functional solvent, the solvent prepared under the mild condition has biological activity and temperature-sensitive phase change characteristics, a medicine storage cavern can be formed on the skin surface in situ, long-acting slow release and efficient transdermal absorption of active ingredients are achieved, and the curative effect and safety of a preparation are improved.

The present disclosure describes topical ketorolac compositions that comprise a eutectic solvent, such as choline chloride and propylene glycol, and methods and uses thereof. The compositions of the present disclosure are capable of delivering an effective amount of ketorolac through the skin and are believed to be useful in treating inflammation and / or pain, such as gout.

The invention relates to the technical field of material testing and analysis, and discloses a quantitative determination method for effective components in a traditional Chinese medicine capsule, which comprises the following steps: mixing choline chloride and ethylene glycol to prepare a deep eutectic solvent system; the traditional Chinese medicine capsule is placed in the eutectic solvent system, a composite frequency ultrasonic field is applied, a sound pressure amplitude step is generated by alternately switching a first working frequency and a second working frequency, and the eutectic solvent system is driven to complete solvent exchange in the medicine powder micropores; according to the method, the diffusion equilibrium of a microscopic interface is broken through the physical suction effect generated by sound pressure step, a solvent saturation dead zone in the compact particles is eliminated, and on the basis of integration of extraction and purification, the extraction and purification efficiency is greatly improved. And the accuracy and the stability of quantitative response signals are improved.

The invention discloses a cholesterol modified double-stranded DNA membrane skeleton liposome delivery system and a preparation method and application thereof, and belongs to the technical field of drug delivery. The system is composed of cholesterol, distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine modified by methoxy polyethylene glycol and double-stranded DNA (chol-dsDNA) modified by 5 '-cholesterol, and the chol-dsDNA is anchored on the inner side and the outer side of a liposome membrane through a hydrophobic effect to form a bionic skeleton. The system is excellent in mechanical stability, low in drug leakage rate, high in tumor targeted enrichment capacity and good in biocompatibility, can efficiently entrap irinotecan hydrochloride and other hydrophilic drugs, is used for tumor treatment, and is simple and convenient to prepare and easy to scale.

The application discloses a method for preparing goldfish feed from fermented abalone viscera powder, and comprises the following steps: preparing fermented abalone viscera powder, including raw material pretreatment, strain activation, anaerobic fermentation and final treatment; preparing a formula of the goldfish feed, including fermented abalone viscera powder, spirulina powder, fish meal, soybean meal, rice bran, wheat flour, fish oil, alpha-starch, soybean lecithin, calcium dihydrogen phosphate, vitamin premix, mineral premix, betaine, garlicin, VC-phosphate, lysine and choline chloride; and preparing the goldfish feed, including accurate batching, uniform mixing, moisture adjustment and molding, grading granulation, drying and cooling and grading screening. The fermentation and feed preparation process is simplified, the complicated enzymolysis-fermentation combined process is abandoned, no professional technical personnel are needed, and the household breeders can prepare the feed through simple equipment, and the enterprises can mass-produce the feed; the formula is optimized for goldfishes in different growth stages, is suitable for multiple goldfishes such as golden goldfish and grass goldfish, and has high application flexibility.

The present disclosure provides a soothing repair composition for dry sensitive skin and its preparation method and application, belonging to the technical field of cosmetics. The soothing repair composition of the present disclosure is a liposome structure. Cephalin and ceramide-EOP form a cephalin-ceramide complex, which serves as the shell layer of the liposome. The plant moulting hormone and glycerophosphoinositol choline salt are wrapped inside the liposome. The soothing repair composition with the liposome structure has excellent moisturizing, soothing and repairing effects.

The present invention provides a nutritional composition comprising milk phospholipids and egg phospholipids, particularly suitable as a nutritional composition for infants, also as a nutritional support product for pregnant women and as a nutritional supplement for the elderly, in which phosphatidylcholine and sphingomyelin and hence choline are also highly correlated. The invention provides a nutritional composition containing choline with high bioavailability.

The invention discloses a method for demethylating a lignin derivative, which comprises the following steps of: adding the lignin derivative into an acidic eutectic solvent, stirring and reacting for 0.1-72 hours at 60-200 DEG C, cooling after the reaction is finished, and extracting and separating a product by adopting an organic solvent and water. The acidic deep eutectic solvent is composed of hydrogen bond acceptor choline chloride and hydrogen bond donor p-toluenesulfonic acid, citric acid, oxalic acid dihydrate and the like, the reaction condition of the conversion process is mild, the deep eutectic solvent can be recycled, the cost is reduced, the method is environment-friendly, and the obtained demethylation product can be used as chemicals or can be further converted to prepare materials. And the method has relatively high economical efficiency and application prospect.

The invention discloses a method for preparing benzoyl peroxide gel and application, and belongs to the technical field of medicine preparation. The preparation method comprises the following steps: preparing a ternary eutectic solvent by taking choline chloride, glycerol and benzoic acid as raw materials, mixing benzoyl peroxide with the ternary eutectic solvent to obtain a benzoyl peroxide system, and mixing the benzoyl peroxide system with a gel system on the basis to prepare the benzoyl peroxide gel with relatively high stability, storage stability and antibacterial activity.