This invention discloses a strain of *
Lactobacillus paracasei* capable of converting
cyanocobalamin and promoting its absorption, thereby enhancing brain
nerve repair and improving
cognition, and its postbiotic, belonging to the fields of microbial technology and
pharmaceutical technology. The *
Lactobacillus paracasei* CCFM1527 and its prepared postbiotic provided by this invention promote the growth of
vitamin B1 in the host. 12 The neuroprotective effects of upregulating the expression of absorption receptors and converting CN-CbI to
methylcobalamin include: (1) promoting the upregulation of Amnionless expression in intestinal cells (Caco-2); (2) converting CN-CbI to
methylcobalamin; and (3) promoting the upregulation of Amnionless expression in mouse
ileum. AMN Upregulation of
gene expression (4) significantly increased the levels of
vitamin B in mice. 12 (5) Significantly promotes the expression of MBP and PSD-95 proteins in mice; (6) Improves the decline in cognitive ability in mice, and has great application prospects.