321 results about "B vitamins" patented technology

A dietary supplement of mitochondrial nutrients is designed for relieving stress, preventing and improving stress-related disorders, such as chronic fatigue syndrome, diabetes, age-associated cognitive dysfunction and diseases (Parkinson's and Alzheimer's disease). The supplement composition has the following nutrients: B vitamins (cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, Pantothenate 5-150 mg, folic acid 400-40,000 ug), alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000 mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg, all of which have been individually used experimentally or clinically for relieving stress, preventing and treating age- and stress-related disorders and diseases but no combination of these compounds has been used. Many embodiments also contain at least one adjunct ingredient such as coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

The invention relates to protein feed produced by multi-fungus fermentation with steam explosion rapeseed meal and cotton meal and a method. Rapeseed meal and cotton meal are used as main materials, meat and bone meal, straw and pomace are used as auxiliary materials, and a group of oxic liquid strain and anaerobic liquid strain are inoculated, so the protein feed is obtained. The preparation method is as follows: raw materials are delivered to a steam explosion system to be exploded, and then are released to normal pressure quickly after steam explosion; the materials after steam explosion are delivered to chelation reaction granary and cooled to 30 DEG C, and then are sterilized by microwave. The sterilized materials are delivered to a fermentation granary and the group of the oxic liquid strain is inoculated at the same time, the inoculum concentration is 5 percent, the intermittent ventilation and oxygen supplying are performed, the oxic fermentation time is between 36 and 48 hours; after the oxic fermentation, an anaerobic strain is inoculated, the inoculum concentration is 5 percent, and the sealed anaerobic culture is performed; and when the peptides content reaches 3 percent, the fermentation ends. The protein feed produced by multi-fungus fermentation with steam explosion rapeseed meal and cotton meal and the method have the advantages that toxin of miscellaneous mealis degraded completely after the steam explosion and microorganism fermentation treatment; the protein feed has flavor taste, and contains active substances, such as large amount of B vitamins, a plurality of vezyme and peptides, and so on; in addition, the protein feed has the functions of promoting growth development, resisting diseases.

The invention relates to methods for determining the level of B vitamins in a test sample. The methods can include the steps of obtaining a water soluble vitamin fraction by extraction in acidic aqueous solution of a test sample, wherein the vitamin fraction comprises one or more B vitamins having at least a predetermined minimum concentration; adding a vitamin standard comprising one or more B vitamins of known quantity to a portion of the vitamin fraction of the test sample, wherein said vitamins in the vitamin standard comprise an isotope label and wherein the vitamin standard is added in an amount sufficient to determine the level of the corresponding vitamins in the test sample; and determining the level of one or more vitamins in the test sample corresponding to one or more of the vitamins in the vitamin standard using mass spectrometry.

The invention relates to a tablet candy containing prebiotics and a preparation method thereof. The tablet is prepared from the following components in parts by weight: 1-40 parts of isomaltooligosacharide, 1-20 parts of fructo-oligosaccharide, 1-30 parts of xylooligosaccharide, 5-30 parts of microcrystalline cellulose, 1-15 parts of citric acid, 5-30 parts of xylitol, 5-30 parts of skim milk powder and 0.1-3 parts of magnesium stearate. The tablet candy containing prebiotics is obtained through the steps of crushing all of the raw materials, respectively, filtering through an 80-mesh sieve, mixing evenly, forming a soft material, pelleting, drying, shaping and tableting. The tablet candy containing prebiotics provided by the invention is capable of promoting the multiplication of probiotics in the intestinal tract of the human body and then improving the intestinal environment of the human body, promoting intestinal tract movement, preventing constipation, reducing the multiplication of harmful bacteria, improving the immunity of the human body, promoting the synthesis of group B vitamins and also promoting the absorption of trace elements such as Ca, Fe and Zn.

This invention features our discovery on usages of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms in predicting homocysteine (Hcy) level and/or incidence and prognosis of diseases associated with increased Hcy level in a subject, as well as predicting treatment effects of medicines in the category of Angiotension Converting Enzyme Inhibihor (ACEI) with and without combination with B Vitamins. This invention also features our discovery on laboratory and analytical methods that are essential to the above described usages of MTHFR gene polymorphisms. In addition, this invention features a kit that has translated the above discoveries into a practical and reliable tool that can be applied to accomplish the above described usages of MTHFR gene polymorphisms. This invention represents an important step in realizing personalized medicine, with the goal to tailor diagnosis, prevention and treatment strategy to meet individual needs.

The present invention relates to improved ophthalmic solutions that employ select B vitamins; pyridoxine and its salts; and thiamine and its salts in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions.

The invention discloses a mashed shrimp ball and a preparation method of the mashed shrimp ball. The mashed shrimp ball is prepared from the following raw materials in part by weight: 60-65 parts of smashed shrimp meat, 20-25 parts of diced shrimp meat, 4-5 parts of rice wine, 4-5 parts of egg white, 3-5 parts of sugar, 1.5-2 parts of salt, 1.5-2 parts of cassava raw powder and 3-5 parts of monosodium glutamate, wherein the smashed shrimp meat and the diced shrimp meat are prepared from prawns, the weight ratio of the smashed shrimp meat to the diced shrimp meat in the prepared stuffing is 3 to 1, meat particles of the mashed shrimp ball are full, and the mouthfeel of the mashed shrimp ball is improved; the mashed shrimp ball is processed by the prawns, the prawn is rich in nutrition; the prawns per 100g contain 20% of protein, contain extremely low fat which is not more than 1% and is unsaturated fatty acid generally, also contain multiple mineral elements such as phosphorus and iron, contain the highest calcium content compared with the calcium contents of the other animals and plants, and are also rich in vitamin A and B vitamins; and particularly, magnesium contained in the prawn has the efficacies of protecting the cardiovascular system, reducing the content of cholesterol in blood, preventing arteriosclerosis and preventing and controlling hypertension.

The invention provides the application of a B vitamin, a physiologically or pharmaceutically acceptable salt of the B vitamin, a hydrate of the B vitamin or a mixture of the B vitamin, the salt and the hydrate in the preparation of a composition for controlling body weight and blood sugar and/or moderating the insulin resistance. The invention also provides a method for losing weight by applying the B vitamin or a composition thereof, and an application of a compound B vitamin or a composition containing B vitamin and having the functions of preventing, controlling or curing diabetes and diseases or symptoms regarding obesity. The composition has high safety, is liable to be accepted by the market, and has the advantages of high solubility, easy absorption and good stability.

The invention discloses yeast nutritious food and a preparation method thereof. The yeast nutritious food adopts yeasts as a main raw material, comprises milk powder, maltodextrin , lactose, non-dairy creamer, calcium carbonate, starch, white granulated sugar, flavoring agent and essence and also comprises folic acid, B vitamins, vitamin A, vitamin C, selenium-rich yeast, zinc-rich yeast, chromium-rich yeast, iron-rich yeast, other trace elements-rich yeast, calcium carbonate, dehydrated onion slice, microcrystalline cellulose, starch, cocoa powder, fruit and vegetable powder, sesame, milk tea powder, soy-bean milk powder and oat flakes. The invention adopts multiple raw auxiliary materials, and can be used for preparing yeast nutritious food in such forms as powder, flakes and tablets through various preparation processes, so as to develop nutritious food with tastes applicable to various groups. Moreover, multiple raw auxiliary materials can be added. Compared with the existing yeast nutritious food, the yeast nutritious food of the invention has the function of significantly improving the immunity of the user.

The present invention discloses a composition of matter useful for insect repellency, which is topically applied in the form of a spray, liquid, cream, gel, ointment or towelette comprising a B vitamin, and in particular vitamin B1 (thiamine) in any chemical form, as the sole active ingredient or in combination with other active ingredients known to provide insect repellency. Such thiamine component of a final formulation is particularly effective when thiamine concentrations exceed 0.01% w/v in the topical mixture, and its use is preferred when concentrations are between 0.01 to 30% w/v thiamine. Said formulation is increased in effectiveness for insect repellency when additional ingredients are also added which are also known to provide insect repellency.

The invention relates to pharmaceutical composition containing GKAs (glucokinase activators) and B vitamins. The pharmaceutical composition is prepared from a therapeutic effective dose of one of GKAs as well as medicinal precursors, active metabolites or GKA salts, one or more of a therapeutic effective dose of the B vitamins and pharmaceutically acceptable carriers, wherein the GKAs mainly comprise TTP399, HMS5552, PF-04937319, LY2608204, PF-04991532 and GKM-001; the content of the B vitamins is 0.01-50 mg and adopt folic acid compounds as the first choice. The invention further relates to an application of the composition in preparation of drugs for treating diabetes mellitus and preventing or delaying complications of diabetic angiopathy.

The invention provides a liver-protecting and alcoholism-relieving product using Saccharomyces cerevisiae, which contains over 42 percent of proteins, more than 500 milligrams of total B vitamins per kilogram and more than 800 milligrams of glutathione per kilo gram, as main materials. The invention also provides a method for producing the liver-protecting and alcoholism-relieving product.

A composition is provided which contains policosanol and B vitamins and which may be used for treating and or reducing hypercholesterolemia and hyperhomocysteinemia diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, Lp(a), triglycerides, homocysteine, coronary heart disease (heart attacks and strokes), carotid artery disease, inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, anxiety, depression, neurodegenerative disorders (such as but not limited to Alzheimers), and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and B vitamins which together effectively lower the risk of heart disease. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to B vitamins.

The invention relates to wheat bran puffed food and a manufacturing method thereof. The wheat bran puffed food comprises the following raw materials: wheat bran, stevioside or sugar, psyllium husk powder, salt and baking soda. The manufacturing method comprises the following steps : crushing the wheat bran, screening with a 30-mesh sieve, uniformly mixing the wheat bran wiht the rest raw materials, adding water, uniformly agitating, feeding into a material box of a double-screw extruder, feeding into a drying box to dry after extrusion and puffing treatment and obtaining the wheat bran puffed food. The wheat bran puffed food has the advantages that the wheat bran puffed food adopts the wheat bran and the psyllium husk powder as the raw materials, contains rich dietary fiber, group-B vitamins and other nutrient elements, is high-dietary fiber food, meets the demand quantity of a human body to the dietary fiber and has the effects of preventing the high blood pressure and the heart disease, preventing the arteriosclerosis, easing the constipation and enhancing the human immunity after long-term eating.

The present invention relates to improved ophthalmic solutions that employ select B vitamins; pyridoxine and its salts; and thiamine and its salts in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions.

The invention relates to a sugar-lowering drug composition and application thereof. The composition comprises 1) medicinal dosage of vildagliptin, 2) medicinal dosage of any one or combination of thiazolidinedione sugar-lowering drugs or medicinal salt thereof, sulfonylurea sugar-lowering drugs or medicinal salt thereof or biguanide sugar-lowering drugs or medicinal salt thereof and 3) B vitamins. The invention relates to application of the sugar-lowering drug composition to preparing the drugs for treating and/or controlling diabetes or diabetic complications. The composition can effectively overcome the defect that type 2 diabetes can not be controlled by singly taking the commonly used sugar-lowering drugs or vildagliptin in the prior art and simultaneously addition of the B vitamins is conductive to enhancing the treatment effect of the drug, effectively controlling the blood sugar, protecting the endothelial cell functions in a synergic manner, slowing rising of plasma homocysteine of the diabetes patients, especially the diabetes patients associated with chronic complications and reducing the diabetic complications.

Described is a composition for the prevention and treatment of symptoms associated with ethyl alcohol consumption. The composition comprises silymarin, salicin, at least one B vitamin, magnesium, molybdenum and manganese. Treatment of symptoms associated with the consumption of ethyl alcohol involves ingesting the described composition prior to, during, or after the consumption of the alcohol.

Metabolizing alcohol requires B vitamins and other nutrients in the liver. A person who drinks a large quantity of alcohol depletes those vitamins and nutrients. With lowered vitamins and nutrients a person feels uncomfortable following drinking, commonly called a hangover. A hangover ameliorative has four pills of vitamins and nutrients taken as two pills before drinking and two pills before sleeping. The hangover ameliorative overloads a person with nutrients consumed during metabolization of alcohol resulting in better sleep and less chance for a headache.

The invention provides a pharmaceutical composition which comprises calcium channel blockers of a medicinal dose, angiotensin II receptor antagonists of a medicinal dose, one or more of B vitamins of a medicinal dose and pharmaceutically acceptable carriers, wherein the calcium channel blockers are selected from amlodipine, felodipine, israbipine, nicardipine, nifedipine, nisoldipine, nitrendipine, lacidipine, diltiazem or verapamil; the angiotensin II receptor antagonists are selected from candesartan, telmisartan, losartan, valsartan, irbesartan, eprosartan, tasosartan or olmesartan; and the B vitamins are selected from one or more of vitamin B6, vitamin B12, folic acid and calcium leucovorin. The pharmaceutical composition of the invention can improve the curative effect of the hypotensor, enhance the target organ protecting action of the hypotensor, and reduce the morbidity of complications of angina, myocardial infarction and the like.

The invention provides methods for enhancing neurogenesis in an animal. In one embodiment, a method for enhancing neurogenesis in an animal can comprise identifying an animal that is suffering from cognitive decline, that is at risk of becoming cognitively impaired, that is diagnosed with a disease, disorder, or other condition that affects its cognitive abilities, or that is at risk of contracting a disease, disorder, or other condition that affects its cognitive abilities, and administering a composition comprising an unsaturated fatty acid (UFA), a nitric oxide releasing compound (NORC), a B vitamin, and an antioxidant, to the animal, wherein the composition is administered in an amount effective for enhancing neurogenesis in the animal.

A composition for the prevention and treatment of symptoms (for example, a hangover) associated with ethyl alcohol consumption. The composition may comprise a gingerol, a silymarin, a catechin, and a group B vitamin. Treatment of symptoms associated with the consumption of ethyl alcohol may comprise administration of the composition prior to, during, or after the consumption of the alcohol.

The invention discloses a cordyceps polysaccharide protein peptide compound. The cordyceps polysaccharide protein peptide compound comprises, by weight, 10 to 75% of a cordyceps polysaccharide compound, 10 to 60% of soybean protein peptide, 0.05 to 0.1% of calcium ion, 0.01 to 0.03% of B vitamins, and the balance medical or food health care accessory ingredients. Soybean protein peptide, calcium ion, and B vitamins in the cordyceps polysaccharide protein peptide compound can be absorbed by human body preferably because of the synergistic effect of cordyceps polysaccharide; and the synergistic effect of cordyceps polysaccharide, soybean protein peptide, calcium ion, and B vitamins is capable of improving human immunity, and relieving sub-health.

The invention provides a kit for quantitatively detecting niacin, nicotinamide and pantothenic acid in peripheral whole blood at the same time, which mainly consists of dried blood slices (Whatman protein saver 903), capillary blood collection tubes, nicotinic acid and nicotinamide and pantothenic acid vitamin standard substance and its isotope internal standard, trichloroacetic acid, and also includes dry blood spot preparation, dry blood spot pretreatment and detection steps. The nicotinic acid, nicotinamide, and pantothenic acid dry blood spot quantitative kit provided by the present invention combines dry blood spot sampling technology with high performance liquid chromatography-tandem mass spectrometry technology for the quantification of B vitamins, a minimally invasive, minimal blood collection at the same time Realize the evaluation of the nutritional status of multiple B vitamins, and realize the quantitative work of simultaneous detection of multiple vitamins under low sample volume conditions that cannot be accomplished by metabolic enzyme-dependent methods and immunoassay methods.

A soft drink and method of producing a soft drink that is a fortified, normally zero calorie beverage, formulated with natural flavors such as lemon or berry that can be formulated from L-Gluamine, sodium bicarbonate, a potassium salt like potassium chloride or potassium gluconate, caffeine with optional B vitamins, folic acid and vitamin C added for fortification along with a sweetener. This drink mixture can help reduce or eliminate symptoms of a hangover caused by alcohol consumption as well as supply a large portion of the recommended daily requirements for some vitamins and minerals.

The invention relates to a pharmaceutical composition containing SGLT2 (sodium-glucose type 2 transporter) inhibitors and group B vitamins. The pharmaceutical composition consists of SGLT2 inhibitors in therapeutically effective amount and one of medicinal precursors, active metabolites or salts thereof, one or more in group B vitamins in therapeutically effective amount, and pharmaceutically acceptable carriers, wherein the SGLT2 inhibitors mainly comprise dapagliflozin, remogliflozin and sergliflozin and have the content of 2.5-500mg, and the content of the group B vitamins is 0.01-50mg. The invention also relates to application of the composition in preparation of medicines for treating diabetes. The medicine prepared by the pharmaceutical composition provided by the invention has the beneficial effect of obviously preventing or delaying complication of diabetic angiopathies on the basis of effectively reducing blood sugar. In addition, the pharmaceutical composition can be conveniently taken by a patient, and the compliance is improved.

The invention relates to a pharmaceutical composition containing one of angiotensin converting enzyme inhibitors (ACEI) and active metabolites or medical salt thereof in medicine dosage, one or more of B vitamins in medicine dosage, ginkgo biloba extracts (GbE) in medicine dosage and a medical carrier, and relates to application of the pharmaceutical composition in preparing medicines for treating, preventing or retarding stroke. The medicines prepared by the pharmaceutical composition provided by the invention are superior to the simple antihypertensive drugs in the aspect of treating, preventing or retarding stroke and facilitate the patients to take. The invention belongs to the pharmaceutical field.