53987results about How to "Avoid entering" patented technology

An endoscope having a guide tube is described herein. The assembly has an endoscope which is slidably insertable within the lumen of a guide tube. The guide tube is configured to be rigidizable along its entire length from a relaxed configuration. The endoscope has a steerable distal portion to facilitate the steering of the device through tortuous paths. In the relaxed configuration, a portion of the guide tube is able to assume the shape or curve defined by the controllable distal portion of the endoscope. Having assumed the shape or curve of the endoscope, the guide tube may be rigidized by the physician or surgeon to maintain that shape or curve while the endoscope is advanced distally through the tortuous path without having to place any undue pressure against the tissue walls.

An endoscope having a guide tube is described herein. The assembly has an endoscope which is slidably insertable within the lumen of a guide tube. The guide tube is configured to be rigidizable along its entire length from a relaxed configuration. The endoscope has a steerable distal portion to facilitate the steering of the device through tortuous paths. In the relaxed configuration, a portion of the guide tube is able to assume the shape or curve defined by the controllable distal portion of the endoscope. Having assumed the shape or curve of the endoscope, the guide tube may be rigidized by the physician or surgeon to maintain that shape or curve while the endoscope is advanced distally through the tortuous path without having to place any undue pressure against the tissue walls.

A method of communicating with a physiological sensor is disclosed. In an embodiment, the method includes supplying power through a first conductor in a first mode to the physiological sensor and communicating with an information element through the first conductor in a second mode. The physiological sensor includes the information element, a power supply configured to receive and store power from the first conductor in the first mode, and sensing circuitry configured to receive power from the first conductor in the first mode. The power supply releases the stored power to the sensing circuitry in the second mode.

A multiple clip applicator system for tissue clamping of hemostasis includes clip devices of a train and a flexible sheath. To load the flexible sheath with clip devices, a coupling device is used. A shaft head is positioned on an operating wire in the flexible sheath. A receiving opening is formed in the coupling device, for receiving insertion of the shaft head, for mating by press-fit with the fastening clip device. The shaft head is a selected one of plural shaft heads which are different in a shape according to the plural multiple clip assemblies. The receiving opening is a selected one of plural receiving openings having a shape according to corresponding shapes of the plural shaft heads, and adapted to preventing a second shaft head from entry in a first receiving opening and preventing a first shaft head from entry in a second receiving opening.

Embodiments of the present invention are generally directed to apparatus and methods for a plasma-processing chamber requiring less maintenance and downtime and possessing improved reliability over the prior art. In one embodiment, the apparatus includes a substrate support resting on a ceramic shaft, an inner shaft allowing for electrical connections to the substrate support at atmospheric pressure, an aluminum substrate support resting on but not fixed to a ceramic support structure, sapphire rest points swaged into the substrate support, and a heating element inside the substrate support arranged in an Archimedes spiral to reduce warping of the substrate support and to increase its lifetime. Methods include increasing time between in-situ cleans of the chamber by reducing particle generation from chamber surfaces. Reduced particle generation occurs via temperature control of chamber components and pressurization of non-processing regions of the chamber relative to the processing region with a purge gas.

This invention relates to compounds, compositions, and methods useful for modulating BCL2 gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of BCL2 gene expression and / or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of BCL2 genes (e.g., BCL2, BCL-XL, BCL2-L1, MCL-1 CED-9, BAG-1, E1B-194 and / or BCL-A1). The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease, polycytemia vera, idiopathic myelofibrosis, essential thrombocythemia, myelodysplastic syndromes, autoimmune disease, viral infection, and proliferative diseases and conditions

This invention relates to compounds, compositions, and methods useful for modulating mitogen activated protein kinase (MAP kinase) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MAP kinase gene expression and / or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of MAP kinase genes, such as Jun amino-terminal kinase (e.g., JNK-1, JNK-2), p38 (MAPK 14), ERK (e.g., ERK-1, ERK-2) and / or c-Jun.

An innovative bone anchor and methods for securing soft tissue, such as tendons, to bone are described herein Such devices and methods permit a suture attachment that lies beneath the cortical bone surface and does not require tying of knots in the suture.

A system and method for improving a surgeon's vision by overlaying augmented reality information onto a video image of the surgical site. A high definition video camera sends a video image in real time. Prior to the surgery, a pre-operative image is created from MRI, x-ray, ultrasound, or other method of diagnosis using imaging technology. The pre-operative image is stored within the computer. The computer processes the pre-operative image to decipher organs, anatomical geometries, vessels, tissue planes, orientation, and other structures. As the surgeon performs the surgery, the AR controller augments the real time video image with the processed pre-operative image and displays the augmented image on an interface to provide further guidance to the surgeon during the surgical procedure.

This invention relates to compounds, compositions, and methods useful for modulating wingless (WNT) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of WNT gene expression and / or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of WNT genes such as WNT3A and WNT7A.

This invention relates to compounds, compositions, and methods useful for modulating tumor necrosis factor and / or tumor necrosis factor receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of tumor necrosis factor and / or tumor necrosis factor receptor gene expression and / or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of tumor necrosis factor and / or tumor necrosis factor receptor genes, (TNF and / or TNF receptor).

A hearing aid insertable into an ear canal includes a microphone which translates acoustic energy into electrical signals, signal processing circuitry which processes the electrical signals provided by the microphone, a receiver which converts the processed electrical signals into acoustic energy, and a power source connectable to the signal processing circuitry.

A method and apparatus for removing fouling materials from the surface of a plurality of porous membranes (9) arranged in a membrane module (4) by providing, from within the module, by means (10) other than gas passing through the pores of said membranes, gas bubbles in a uniform distribution relative to the porous membrane array such that the bubbles move past the surfaces of the membranes (9) to dislodge fouling materials therefrom. The membranes (9) are arranged in close proximity to one another and mounted to prevent excessive movement therebetween. The bubbles also produce vibration and rubbing together of the membranes to further assist removal of fouling materials.

This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes, such as expressed pseudogenes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism. The invention also provides small nucleic acid molecules with reduced or attenuated immunostimulatory properties and methods for designing and synthesizing such small nucleic acid molecules having improved toxicologic properties while retaining RNAi activity.

In a fixing device, a fixed member is fixedly provided inside a loop formed by a belt, and is pressed against a pressing rotary member via the belt to form a nip portion between the pressing rotary member and the belt to nip a recording medium bearing a toner image. A heating member is fixedly, provided inside the loop formed by the belt to heat the belt. The heating member includes an opening opposing the pressing rotary member. A seal member covers the opening in the heating member to prevent a foreign substance from entering the heating member through the opening in the heating member. A reinforcement member is fixedly provided inside the heating member and pressed against the fixed member via the seal member to reinforce the fixed member.

A durable unitary lens filter is provided for use with a touch sensitive display device for associated control process equipment. A front cover secures the unitary lens filter to the machine. The lens assembly includes a mounting bezel that supports an intermediate lens securing an integral rear lens filter through which a responsive display shows process information to an operator. The front cover captivates the integral bezel to secure the lens to the associated process device. The lens is molded from a semi-rigid material composition including glass fibers. An internal retainer compressibly captivates the bezel against the front cover. The bezel periphery extends substantially beyond the outermost peripheral edge of the rear lens so that forces thereto are transferred and dissipated to the machine housing.

A one-piece cylindrical bandstop filter for medical lead systems incorporates parallel capacitive and inductive elements in a compact cylindrical configuration. The compact cylindrical configuration of the bandstop filter does not add significantly to the size or weight of the medical lead system. Preferably, the bandstop filters are of biocompatible materials or hermetically sealed in biocompatible containers. The parallel capacitive and inductive elements are placed in series with the medical lead system, and are selected so as to resonate at one or more selected frequencies, typically MRI pulsed frequencies.

A system and method for improving a surgeon's vision by overlaying augmented reality information onto a video image of the surgical site. A high definition video camera sends a video image in real time. Prior to the surgery, a pre-operative image is created from MRI, x-ray, ultrasound, or other method of diagnosis using imaging technology. The pre-operative image is stored within the computer. The computer processes the pre-operative image to decipher organs, anatomical geometries, vessels, tissue planes, orientation, and other structures. As the surgeon performs the surgery, the AR controller augments the real time video image with the processed pre-operative image and displays the augmented image on an interface to provide further guidance to the surgeon during the surgical procedure.

A pump for dispensing a fluid from a reservoir provides a drive system seal within the pump. The pump includes a reservoir cavity adapted to receive the reservoir, and a drive system. The pump also includes at least one plunger slider having one end coupled to the drive system and the other end coupled to the reservoir. The plunger slider is adapted to translate from a retracted position to an extended position to dispense the fluid from the reservoir in response to actuation by the drive system. The pump further includes a sealing ring mounted around the plunger slider, and a spring disposed within the sealing ring. The sealing ring with the spring disposed therein is adapted to allow the plunger slider to translate from the retracted position to the extended position, and to prevent entry of fluid from the reservoir cavity into the drive system.

A process for production of an agglomerate comprises the steps of: passing a flow of one or more gaseous reactants into a reactor; reacting the one or more gaseous reactants within a reaction zone of the reactor to form product particles; agglomerating the product particles into an agglomerate; and applying a force to the agglomerate to displace it continuously away from the reaction zone.

The present invention concerns methods and reagents useful in modulating Parkinson genes, for example, PARK1 (SNCA), PARK2, PARK7, and / or PARK5 gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against SNCA gene expression and / or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of Parkinson Disease (PD), and any other disease or condition that responds to modulation of PARK1 (SNCA), PARK2, PARK7, and / or PARK5 expression or activity.

The invention relates to a food processing machine with an electric sucking pump and a method for vacuumizing to produce foodstuff liquid. The food processing machine comprises a crushing cutter device, a machine head or a machine base, a motor, a barrel and a control circuit board, wherein the barrel is provided with a sealing device, has or does not have a heating device. An electric sucking pump is arranged on the machine head, the machine base, the sealing device, the barrel or a barrel handle of the food processing machine, the sucking port of the electric sucking pump is positioned in the barrel and above the foodstuff liquid level, the exhaust port of the electric sucking pump is communicated with the outer part of the barrel; and the electric power source of the electric sucking pump is an independent motor, an electromagnetic vibration device, a piezoelectric ceramic vibration device or the crushing cutter device of the food processing machine. A sealing mode is adopted to seal the barrel of the food processing machine, the electric sucking pump is used to pump air out of the barrel, then crushing and heating are carried out to crush and heat the foodstuff in the barrel of the food processing machine under the vacuum condition, the oxidation of the foodstuff liquid is greatly reduced and avoided for the crushing and heating processes, so the nutritive loss is reduced, and the good taste and appearance color are kept.

A refillable atomizing assembly with a liquid reservoir for an electronic cigarette. The assembly includes a housing and a mouthpiece that is removably engaged to the housing. A liquid reservoir is disposed within the housing, and separated from the aerosol outlet by an outlet chamber. The liquid reservoir is refillable by removing the mouthpiece and dispensing the liquid into the outlet chamber. An atomizing chamber is adjacent to the reservoir and opposite of the outlet chamber. An aerosol conduit connects the atomizing chamber to the outlet chamber. An isolation member is disposed within the outlet chamber. A liquid passage through the isolation member allows the liquid placed into the outlet chamber to flow into the reservoir. A shield portion of the isolation member is located about the aerosol conduit to prevent liquid from entering. An aerosol vent through the shield portion enables the flow of the aerosol therethrough.

A portable analysis appliance includes a housing and a magazine for holding test elements. A delivery device is provided for delivering the test elements from a first position in the interior of the magazine to a second position lying at least partially outside the magazine and inside the housing. The delivery of the test elements including a first movement out of the interior of the magazine and a second movement by means of a guide into a presentation position.

An apparatus including a support member, the support member including a first fluid passage, a mandrel coupled to the support member, the mandrel including: a second fluid passage, a tubular member coupled to the mandrel, and shoe coupled to the tubular liner, the shoe including a third fluid passage, and a drilling assembly coupled to the shoe, wherein the first, second and third fluid passages and the drilling assembly are operably coupled.

Provided herein are systems and methods for separation of particulate from water using ultrasonically generated acoustic standing waves.

A building panel, such as a flooring panel or wall panel and a method of assembling the same into a floor, wall cladding, etc. The panel is provided with a locking means in the form of groove (6) and tongue (7) forming a tongue / groove joint for assembling of the panels. In a preferred embodiment, the groove (6) and the tongue (7) are made of water resistant material and formed with a snap-together joint.

A touch-panel liquid crystal display is provided. The touch-panel liquid crystal display comprises a casing, a liquid crystal display module, a touch panel, a transparent conducting layer, a controlling circuit board, and a conductive buffer layer. The transparent conducting layer is disposed on the surface of the touch panel. The conductive buffer layer is disposed between the casing and the transparent conducting layer. The conductive buffer layer can be electrically connected to the casing or the conductive module casing of the liquid crystal display module so that the electrostatic charges can be released from the touch-panel LCD to ground. Hence, the electrostatic charges are effectively released from the touch panel and are prevented from entering into the controlling circuit board and the other electronic devices in the LCD.