402 results about "Biological membrane" patented technology

The invention relates to the technical field of water treatment equipment, in particular to an ultrasonic water treatment equipment control method and system based on variable-frequency vibration waves. According to the method, based on preset fluid working condition parameters, ultrasonic frequency conversion vibration wave signals covering multiple frequency bands are dynamically generated, and a vibrator array is driven to generate a composite sound field; a cavitation effect and an activation effect are synchronously excited in a fluid medium through variable-frequency vibration wave signals, so that physical form depolymerization and surface charge distribution change of scale forming substances occur; a shearing effect is formed on a fluid-pipe wall boundary layer, an attached state biological membrane structure is stripped, and the microscopic binding force of a crystallized scale body is loosened; monitoring the dispersion degree of scale-forming substances in the fluid and the state of a boundary layer, and adjusting the frequency band combination and energy distribution of variable-frequency vibration waves to maintain scale inhibition; and continuously optimizing the frequency conversion strategy and the sound field intensity according to the feedback data of the scale inhibition maintenance state. Through intelligent multi-band frequency conversion control of the ultrasonic water treatment equipment, efficient and environment-friendly water treatment and scale prevention effects are realized.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention provides a nano-drug based on atomic layer deposition and a preparation method of the nano-drug, mesoporous silica is taken as a carrier, bimetallic nanoparticles are precisely deposited through ALD, and chemotherapeutic drugs and antibacterial components are loaded by combining amination and targeted PEG modification, so that the following functions are realized: (1) H2O2 in a tumor microenvironment is catalyzed to generate reactive oxygen species (ROS); removing fusobacterium nucleatum and damaging a biological membrane of the fusobacterium nucleatum; (2) GSH is consumed through Fenton reaction, and tumor drug resistance is reversed; and (3) the drug is released in pH response, and tumor cells are accurately killed. The invention further provides application of the nano-drug based on atomic layer deposition in treatment of related drug-resistant colorectal cancer induced by fusobacterium nucleatum, the process is controllable, the biocompatibility is excellent, the treatment effect on the drug-resistant colorectal cancer is remarkably improved, and the nano-drug has wide clinical application prospects.

The invention discloses a Fe / C loaded membrane module, a PN / A-MABR autotrophic nitrogen removal device, a preparation method and a sewage treatment method, and belongs to the technical field of sewage treatment. According to the invention, the problem that the treatment effect is influenced by NO3 <->-N accumulation in the existing membrane aeration coupling partial nitrification-anaerobic ammonia oxidation process is solved. Comprising a frame and a membrane body attached to the outer portion of the frame, the membrane body comprises a hydrophobic organic membrane layer, an iron-carbon material layer and a biological membrane layer which are sequentially arranged, and the hydrophobic organic membrane layer is attached to the outer portion of the frame. The iron-carbon material is added between the hydrophobic organic membrane layer and the biological membrane layer, the iron-carbon micro-electrolysis process is coupled with the dissimilatory process of nitrate generated by microbial metabolism, the removal of NO3 <->-N generated by anaerobic ammonia oxidation is enhanced, and the total nitrogen removal efficiency is improved.

The invention discloses a self-cleaning composite piezoelectric ceramic membrane as well as a preparation method and application thereof, and belongs to the field of composite ceramic membranes. The technical problem that an existing ceramic membrane separation technology is poor in biomembrane pollution resisting effect is solved. According to the preparation method, the barium titanate ceramic membrane is firstly prepared to serve as the base membrane, then the copper oxide one-dimensional nanostructure is loaded on the piezoelectric ceramic substrate, and the base membrane has a large membrane surface area and can be combined with more catalysts, so that more active sites are provided for catalytic reaction; according to the composite membrane, the hydrophilicity, the anti-pollution performance and the piezoelectric catalysis self-cleaning performance of the membrane are remarkably improved, and pollutants in water can be quickly and effectively separated, so that the flux and the anti-pollution performance of the membrane are improved.

The invention discloses a preparation method of photo-thermal-MMP dual-response matrix hydrogel and application of the photo-thermal-MMP dual-response matrix hydrogel in diabetic wound repair, and belongs to the technical field of biological medicine. According to the present invention, the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is composed of an amnion source photo-crosslinked matrix hydrogel, curcumin-loaded ZIF-8 nanoparticles and MMP2 peptide modified polydopamine, and the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is obtained; the ZIF-8 nanoparticles decline in an acid environment to release zinc ions, destroy bacterial cell membranes, enhance the permeability of a biological membrane and cooperatively kill drug-resistant bacteria in combination with a photothermal effect, Cur is loaded through ZIF-8 to form Cur-coated ZIF-8, then a Cur-coated ZIF-8-coated MMPDA / dAMG double-drug-loading system is constructed through an MMPDA medium, and a photothermal antibacterial, anti-inflammatory and regeneration-promoting multi-mode therapy is formed for a wound surface in the acid environment. Therefore, wound healing is accelerated.

The invention discloses a device and process for treating pharmaceutical wastewater through an internal electrolysis method. The device comprises a pretreatment unit, an internal electrolysis reaction unit, a precipitation separation unit, a pH adjusting unit and a control system which are sequentially connected. The internal electrolytic reaction unit comprises a reaction tower body, the top of the reaction tower body is provided with a water inlet, and the bottom is provided with a water outlet; a supporting layer, an iron-carbon micro-electrolysis filler layer, a catalytic oxidation layer and a biological membrane layer are sequentially arranged in the reaction tower body from bottom to top, the iron-carbon micro-electrolysis filler layer comprises an iron-carbon composite filler, and the mass ratio of iron to carbon in the iron-carbon composite filler is (1: 1)-(3: 1). The internal electrolysis reaction unit with a multi-level filling structure is adopted, iron-carbon micro-electrolysis, catalytic oxidation and biodegradation are organically combined to form a synergistic effect, the removal efficiency of refractory organics in the pharmaceutical wastewater is remarkably improved, and the COD removal rate can reach 80% or above.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The invention relates to the technical field of sewage treatment, in particular to a preparation method of a degradable bactericide for an oil field. According to the invention, a hydroxypropyl guanidine gum-polycaprolactone-ethylenediamine fragment copolymer is taken as a carrier, a methylisothiazolinone quaternary ammonium salt (Q-MIT) bactericide is loaded, and the degradable bactericide for the oil field is obtained by cooperating with a dodecyl ethyl sulfide (TC-SE) bactericide and combining with sodium polyaspartate. A carrier forms a hydrogen bond with a polar group on the surface of a biological membrane through a hydroxypropyl guanidine gum main chain to realize targeted anchoring, a polycaprolactone branched chain encapsulates Q-MIT through a hydrophobic effect, primary amino groups of ethylenediamine are introduced to form a pH sensitive Schiff base bond with Q-MIT, and the primary amino groups and adipic dihydrazide form a thermal response hydrazide bond to construct a dual dynamic covalent bond, so that controlled release of Q-MIT is realized, and the biomembrane is prepared. And moreover, the components of the whole system are connected through degradable chemical bonds, so that the environmental protection property and sustainability of oil field operation are guaranteed.

The invention relates to bacteriostatic bentonite cat litter and a preparation method thereof, and belongs to the technical field of pet supplies. The bacteriostatic bentonite cat litter sequentially comprises a sodium bentonite matrix embedded with a bacteriostatic agent, a metal oxide layer and a biological membrane layer from inside to outside, the sodium bentonite matrix is obtained by mixing and aging bentonite and a sodium modifying agent in a solvent. When the biological membrane is in contact with excrement, the outer-layer biological membrane preferentially blocks liquid permeation, the middle-layer nano ZnO still generates active oxygen in a weak light environment, and the inner-layer Ag < + >-loaded zeolite slowly releases and inhibits bacteria, so that the antibacterial persistence can be improved. The bacteriostatic bentonite cat litter disclosed by the invention is remarkable in deodorization and antibacterial effects, does not stick to hands when being used, does not generate dust, and has relatively strong caking performance.

The invention relates to the technical field of sewage treatment, particularly discloses an iron oxide red wastewater treatment system and treatment method based on anaerobic ammonia oxidation coupled AI prediction, and solves the problems of insufficient prediction capability and high operation cost in the prior art. The system comprises a sewage treatment module and an AI control module, wherein the sewage treatment module adopts an integrated biofilm process anaerobic ammonia oxidation system, is equipped with a sensing equipment group to detect water quality parameters, and controls the equipment group to execute instructions; the AI control module receives water quality data through a real-time data interface, generates feature data in combination with a production plan and a scheduling table, predicts water quality by using a GRU-QR model and outputs an advanced control instruction, and then dynamically optimizes the model and triggers compensation control according to actually measured data to form double closed-loop control. The system has the advantages of stable effluent ammonia nitrogen, high efficiency, improvement of regulation and control precision, reduction of medicament dosage and the like, and can effectively reduce the cost and realize high-intelligence control.

The invention relates to the field of adsorption materials, in particular to a discrete carbon-based biological base material for targeted treatment of high-concentration organic wastewater and a preparation process thereof.The discrete carbon-based biological base material is prepared from, by weight, 65-70 parts of activated carbon fibers, 8-10 parts of PLA fibers, 5-7 parts of sodium lignin sulfonate, 5-8 parts of ferroferric oxide magnetic particles and 8-10 parts of a carbon nitride catalyst; biPO4 is doped in the carbon nitride catalyst. According to the discrete carbon-based biological base material, the activated carbon fibers rapidly adsorb organic matters in high-concentration wastewater, the PLA releases a carbon source and accelerates formation of a biological membrane, and the biological membrane is degraded by taking the adsorbed organic matters as a substrate; the carbon nitride catalyst generates active oxygen under visible light to oxidize small molecular acid, and ferroferric oxide magnetic particles catalyze the reaction to break refractory toxins (such as antibiotics); after the reaction, the magnetic field recovers the material, sodium lignin sulfonate protects ferroferric oxide magnetic particles from corrosion, and regeneration performance is provided.

The invention relates to the technical field of biological medicine, in particular to 7-dehydrocholesterol liposome and application thereof. According to the invention, a biological membrane modified liposome is constructed, and the biological membrane modified liposome comprises an ROS responsive liposome, a neutrophile granulocyte membrane and a renal tubular epithelial cell membrane; the biofilm modified liposome has an active oxygen species (ROS) responsive release function and a dual targeting capability, has the advantages of an integrated drug effect carrier, ROS triggered release, dual bionic targeting, strong target cell uptake and multi-mechanism ferroptosis resistance, and can be used for preparing the biofilm modified liposome. The compound can be used for treating ferroptosis related diseases such as acute kidney injury, myocardial ischemia-reperfusion injury and cerebral ischemia-reperfusion injury, and has wide clinical popularization value.

The utility model discloses a biological membrane car washing sewage circulating filter with an external vibrator. The biological membrane car washing sewage circulating filter with the external vibrator comprises a pretreatment system, a biological membrane reactor, a vibrator device, a filtering system, a disinfection system and a water circulation system, the vibrator device is externally arranged, so that the occupied space in the bio-membrane reactor can be reduced, and the distribution of a flow field and a bio-membrane in the bio-membrane reactor cannot be directly influenced. The vibrator device is arranged outside, so that the vibrator device is more convenient to overhaul, maintain and replace, and the internal structure of the bio-membrane reactor does not need to be disassembled.

The application belongs to the technical field of sewage treatment, and particularly relates to a modified biological membrane method MABR sewage treatment device, which comprises a MABR biological membrane, a sedimentation tank, a discharge port, a cleaning assembly and a power assembly, the MABR biological membrane is arranged in the sedimentation tank, the discharge port is arranged at the bottom end of the sedimentation tank, the cleaning assembly comprises a moving plate and a filter barrel, the moving plate is slidingly installed in the inside of the sedimentation tank, the outer wall of the moving plate is attached to the inner wall of the sedimentation tank, the filter barrel is provided with an opening, and the filter barrel is arranged on the opening; the filter barrel is driven to slide by the moving plate, so that the sediments can be pushed to one side of the sedimentation tank; the sliding of the cleaning assembly is controlled by the power assembly; the end of the moving plate, which is away from the filter barrel, is slidingly installed with a first baffle and a second baffle; the first baffle and the second baffle are controlled to slide relative to each other; and the above structure can effectively improve the efficiency of sewage treatment.

The utility model discloses a three-phase circulation bioreactor. The three-phase circulation bioreactor comprises a shell, a communicated exhaust pipe is fixedly connected to the center of the top of the shell; a communicated overflow pipe is fixedly connected to the side wall of the top of the shell; a blow-off pipe and a water inlet pipe which are communicated with each other are fixedly connected to the periphery of the bottom of the shell; a net plate is fixedly connected to the middle of the interior of the shell; a biofilm carrier filler is arranged at a position, corresponding to the upper part of the screen plate, in the shell; the gas escapes upwards, so that the gas returns to the upper part of the water body after reaching the bottom of the sewage, the circulation effect is achieved, and the mixing effect of the gas and the sewage is further improved; besides, the spray heads can rotate along with the hollow shaft, and the spray heads on the different vortex-shaped pipes are arranged in a staggered manner, so that the distribution density of the gas in the sewage water body can be improved, the mixing effect between the sewage and the gas is further improved, the biological treatment reaction speed of the sewage is prevented from being influenced, and the purification efficiency of the reactor is improved.

The invention relates to a local magnetothermal coupling biological rotating disc enhanced cold region sewage treatment method and system. The system comprises a reactor, a biological rotating disc for growing a biological membrane, a magnetic heat carrier, an alternating magnetic field generator and a motor for driving the biological rotating disc to rotate, the reactor comprises an air exposure area and a sewage area from top to bottom, a water inlet is formed in the lower part of the left side wall of the reactor, a water outlet flush with the water level of the sewage area is formed in the upper part of the right side wall, the reactor is further provided with vent holes, and the air exposure area is communicated with air through the vent holes; the biological rotating disc is partially immersed in the sewage area and partially exposed to the air exposure area in the radial direction; the air exposure area is located in the magnetic field action range of the alternating magnetic field generator, the magnetic heat carrier is arranged on at least one side of the biological rotating disc, and the magnetic heat carrier generates a magnetocaloric effect under the action of the magnetic field so as to increase the temperature of the biological membrane. According to the invention, the synergistic effect of precise heating of the biological membrane and the metabolic process of the biological membrane is realized, and the efficient and energy-saving sewage denitrification process at low temperature is realized.

The utility model relates to a heat preservation structure of a biological membrane filter tank, which comprises a tank body, a heat preservation framework matched with a tank opening in shape is fixedly arranged above the water surface of the tank body, a heat preservation film is covered above the heat preservation framework, and an air area for air circulation is formed between the heat preservation framework and the water surface. By adopting the scheme, the utility model provides the heat preservation structure of the biological membrane filter tank, which is stable in effluent quality.

The application belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mp-GC21, a precursor thereof and application. The amino acid sequence of the antibacterial peptide Mp-GC21 is shown as SEQ ID NO:1, wherein the C terminal is subjected to amidation modification, and two cysteines are connected through a disulfide bond; and the amino acid sequence of the precursor is shown as SEQ ID NO:3. The antibacterial peptide Mp-GC21 is separated from the flower frog, has broad-spectrum antibacterial activity, and has good bacteriostatic and bactericidal effects on standard strains and clinically derived drug-resistant strains of Acinetobacter baumannii, Escherichia coli and Staphylococcus aureus, and can target to destroy the cell membrane of bacteria, remove the biofilm and inhibit the formation of the biofilm. Moreover, the antibacterial peptide Mp-GC21 has good stability, does not have hemolytic activity, cytotoxicity and in-vivo toxicity, and is not easy to induce drug resistance of strains.

The present application relates to the technical field of geomorphology prediction, in particular to a tidal flat evolution prediction method and system based on a geomorphology model. The method comprises the following steps: obtaining geomorphology data, environmental parameter data and biological membrane characteristic data of a target tidal flat area; the geomorphology data comprises water depth distribution and sediment porosity; the environmental parameter data comprises tidal current velocity, fluid shear force, light intensity and water temperature; the biological membrane characteristic data comprises biological membrane thickness obtained by in-situ sampling; a biological membrane dynamic viscosity coefficient model is constructed based on the biological membrane thickness and the water temperature; the dynamic viscosity coefficient model represents a nonlinear enhancement effect of the biological membrane on sediment viscosity; a biological membrane growth rate feedback model is established based on the water depth distribution and the light intensity; the feedback model quantifies the coupling relationship between biological membrane growth in a deposition area and microtopographic factors; the present application can solve the problem of inaccurate evolution prediction under dynamic interaction of environmental factors.

A method of manufacturing a working wire for a continuous glucose monitoring sensor includes receiving a substrate in a wound configuration. The substrate consists of a cobalt-chromium (Co—Cr) alloy. The substrate is unwound from the wound configuration. The substrate is allowed to naturally transition to a straight, linear configuration. A platinum layer is formed on the substrate. A membrane layer comprising a biological membrane is applied over the platinum layer. The working wire is formed to have a diameter in a range from 0.0025 inches to 0.005 inches. A working wire for a continuous glucose monitoring sensor includes a substrate consisting of a cobalt-chromium (Co—Cr) alloy, a platinum layer disposed on the substrate and a membrane layer comprising a biological membrane disposed over the platinum layer. A diameter of the working wire is in a range from 0.0025 inches to 0.005 inches.

The invention discloses a high-concentration sulfate acid pit water treatment method based on an acid-resistant SRB biological cathode, which comprises the following steps: enabling acid pit water to pass through a grid and then enter a regulating reservoir; introducing the wastewater in the regulating tank into a biological membrane electrochemical device for electrochemical reaction; oxidizing Fe < 2 + > in the wastewater into Fe < 3 + > on a titanium-based IrO2 anode plate and releasing electrons in an anode chamber; in the cathode chamber, an acid-resistant SRB bacterial film loaded on the surface of the carbon felt electrode reduces SO4 < 2-> into S < 2-> by utilizing transferred electrons; cO2 microbubbles are introduced into the liquid in the cathode chamber to react with S < 2-> to generate sulfur precipitates, and the reacted mixed liquid enters a cyclone separator to realize gas-solid separation; and carrying out hydrolysis reaction on Fe < 3 + > in the effluent of the anode chamber to generate Fe (OH) 3 precipitate, mixing the Fe (OH) 3 precipitate with sodium silicate, and calcining to convert the mixture into magnetic alpha-Fe2O3. The method can effectively remove SO4 < 2-> and recover iron sludge.

The invention discloses a saccharomyces boulardii colon delivery system which comprises the following steps: the survival rate in gastric juice is enhanced, and the residence time in the colon is increased, so that the treatment effect of the saccharomyces boulardii is enhanced. Saccharomyces boulardii is taken as a research object, in order to improve the bioavailability of the Saccharomyces boulardii in gastrointestinal tracts and prolong the adhesion time of bacteria in intestinal tracts, a layer-by-layer electrostatic self-assembly method is adopted, PDAD (poly dimethyl diallyl ammonium chloride), PSS (sodium polystyrene sulfonate), CS (chitosan) and SA (sodium alginate) are taken as biological membranes to coat the Saccharomyces boulardii, and the coated Saccharomyces boulardii is prepared. Then a series of characterization is carried out, and the effect of the delivery system is verified through in-vitro artificial gastric juice tolerance tests and mouse intestinal colonization.

The invention relates to the technical field of water treatment, in particular to a short-cut nitrification process which comprises a water inlet area, a short-cut nitrification area and the like, nitrate nitrogen is refluxed by a circulating pump and sprayed to a filler layer through a water distribution pipe to realize denitrification, flora mass transfer and biological membrane updating are promoted by combining mechanical shear force, and a DO gradient is formed through aeration to realize coupling of synchronous nitrification and short-cut nitrification. And ammonia nitrogen and nitrite nitrogen directly generate nitrogen. According to the process, the denitrification efficiency can be improved to 95% or above, the aeration energy consumption is reduced by 40-50%, the sludge yield is reduced by 30% or above, and the process is low in equipment investment, high in adaptability and suitable for high-ammonia-nitrogen industrial wastewater treatment.

The application discloses a high-concentration sulfate radical acid mine water treatment method based on acid-resistant SRB biological cathode, which comprises the following steps: after the acid mine water is filtered through a grid, the acid mine water is fed into an adjusting tank; the wastewater in the adjusting tank is fed into a biological membrane electrochemical device to perform an electrochemical reaction; in an anode chamber, Fe 2+ in the wastewater is oxidized into Fe 3+ and releases electrons; in a cathode chamber, the acid-resistant SRB bacterial membrane loaded on the surface of a carbon felt electrode utilizes the transmitted electrons to reduce SO4 2‑ into S 2‑ ; CO2 micro-bubbles are fed into the liquid in the cathode chamber to react with S 2‑ to generate sulfur precipitate, and the mixed solution after the reaction is fed into a cyclone separator to realize gas-solid separation; Fe 3+ in the water in the anode chamber generates Fe(OH)3 precipitate through a hydrolysis reaction, the Fe(OH)3 precipitate is mixed with sodium silicate, and is calcined to be converted into alpha-Fe2O3 with magnetism. The method can effectively remove SO4 2‑ and recover iron mud.

This invention discloses a target-gated ratiometric pH sensor based on a dual CRISPR system of tetrahedral framework nucleic acids, belonging to the fields of biomedicine and nucleic acid nanotechnology. The sensor uses tetrahedral framework nucleic acids as a rigid scaffold, precisely assembling Cas12a, Cas13a, and their corresponding fluorescent reporter molecules in a 1:1 stoichiometric ratio. Their orthogonal pH responses form the basis of the ratiometric sensing. Target recognition-pH sensing logic gating is achieved through target-specific crRNA design. Cholesterol modification allows for stable anchoring on the lipid membrane surface. This invention also discloses the sensor's fabrication, membrane anchoring, pH monitoring, and target-gated function implementation methods. This sensor possesses advantages such as high-precision ratio measurement, accurate spatial arrangement, high specificity, stable membrane anchoring, and a wide pH response range, and can be used for precise monitoring of pH dynamics at biomembrane interfaces and during extracellular vesicle fusion.

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The invention relates to an in-situ integrated Joule hot membrane structure for an MABR (Membrane Aerated Baffled Reactor) and an application of a bioreactor for treating low-temperature wastewater, belonging to the field of low-temperature wastewater treatment. The membrane structure comprises a biological carrier layer and a Joule heating layer; the biological carrier layer is made of one or more of silicone rubber, polyvinylidene fluoride, polyether sulfone, polyethylene and polypropylene; the surface of the biological carrier layer is required to be high in oxygen permeability, and the thickness of the biological carrier layer is 100-300 microns; the Joule heating layer is made of one of carbon felt, graphite felt or graphene heating sheets; the void ratio of the Joule heating layer is 70%-90%, and the surface aperture distribution is 10-100 [mu] m. Current is applied to the membrane structure, and heat is generated through the Joule heating effect of the membrane structure. The heat achieves the function in a heat conduction mode, and through heat conduction of the substrate, a stable and appropriate growth temperature environment is maintained for the biological membrane attached to the substrate. The synchronous thermal management strategy ensures that the biological membrane keeps high metabolic activity, so that efficient biodegradation of pollutants in the low-temperature wastewater is realized.

The utility model provides a sludge self-inoculation type bio-membrane reactor, which relates to the technical field of bio-membrane reactors and comprises a reactor, a storage tank and a clean water tank, the storage tank and the clean water tank are respectively arranged on the left side and the right side of the reactor, a packing area is arranged on the lower portion inside the reactor, and a lifting pump is arranged at the bottom inside the storage tank. A filler area is arranged in the reactor, a water inlet area is arranged at the lower part in the reactor, a bearing plate is arranged in the reactor below the filler area, the output end of the lifting pump is connected with the water inlet area through a connecting pipe, and an air blower is arranged at one side of the reactor; according to the utility model, continuous contact can be formed between inoculated sludge and biological stuffing, the contact time and the inoculation area are increased, the formation process of a biological membrane is accelerated on the basis of providing external oxygen supply and nutrition conditions, the formation time is shortened, the adhesion effect is optimized, and a good inoculation effect is achieved in the inoculation process of domestic sewage with a low carbon-nitrogen ratio.

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.