204 results about "Biological membrane" patented technology

The invention discloses a self-cleaning composite piezoelectric ceramic membrane as well as a preparation method and application thereof, and belongs to the field of composite ceramic membranes. The technical problem that an existing ceramic membrane separation technology is poor in biomembrane pollution resisting effect is solved. According to the preparation method, the barium titanate ceramic membrane is firstly prepared to serve as the base membrane, then the copper oxide one-dimensional nanostructure is loaded on the piezoelectric ceramic substrate, and the base membrane has a large membrane surface area and can be combined with more catalysts, so that more active sites are provided for catalytic reaction; according to the composite membrane, the hydrophilicity, the anti-pollution performance and the piezoelectric catalysis self-cleaning performance of the membrane are remarkably improved, and pollutants in water can be quickly and effectively separated, so that the flux and the anti-pollution performance of the membrane are improved.

The invention relates to the technical field of sewage treatment, in particular to a preparation method of a degradable bactericide for an oil field. According to the invention, a hydroxypropyl guanidine gum-polycaprolactone-ethylenediamine fragment copolymer is taken as a carrier, a methylisothiazolinone quaternary ammonium salt (Q-MIT) bactericide is loaded, and the degradable bactericide for the oil field is obtained by cooperating with a dodecyl ethyl sulfide (TC-SE) bactericide and combining with sodium polyaspartate. A carrier forms a hydrogen bond with a polar group on the surface of a biological membrane through a hydroxypropyl guanidine gum main chain to realize targeted anchoring, a polycaprolactone branched chain encapsulates Q-MIT through a hydrophobic effect, primary amino groups of ethylenediamine are introduced to form a pH sensitive Schiff base bond with Q-MIT, and the primary amino groups and adipic dihydrazide form a thermal response hydrazide bond to construct a dual dynamic covalent bond, so that controlled release of Q-MIT is realized, and the biomembrane is prepared. And moreover, the components of the whole system are connected through degradable chemical bonds, so that the environmental protection property and sustainability of oil field operation are guaranteed.

The invention relates to the field of adsorption materials, in particular to a discrete carbon-based biological base material for targeted treatment of high-concentration organic wastewater and a preparation process thereof.The discrete carbon-based biological base material is prepared from, by weight, 65-70 parts of activated carbon fibers, 8-10 parts of PLA fibers, 5-7 parts of sodium lignin sulfonate, 5-8 parts of ferroferric oxide magnetic particles and 8-10 parts of a carbon nitride catalyst; biPO4 is doped in the carbon nitride catalyst. According to the discrete carbon-based biological base material, the activated carbon fibers rapidly adsorb organic matters in high-concentration wastewater, the PLA releases a carbon source and accelerates formation of a biological membrane, and the biological membrane is degraded by taking the adsorbed organic matters as a substrate; the carbon nitride catalyst generates active oxygen under visible light to oxidize small molecular acid, and ferroferric oxide magnetic particles catalyze the reaction to break refractory toxins (such as antibiotics); after the reaction, the magnetic field recovers the material, sodium lignin sulfonate protects ferroferric oxide magnetic particles from corrosion, and regeneration performance is provided.

The utility model discloses a three-phase circulation bioreactor. The three-phase circulation bioreactor comprises a shell, a communicated exhaust pipe is fixedly connected to the center of the top of the shell; a communicated overflow pipe is fixedly connected to the side wall of the top of the shell; a blow-off pipe and a water inlet pipe which are communicated with each other are fixedly connected to the periphery of the bottom of the shell; a net plate is fixedly connected to the middle of the interior of the shell; a biofilm carrier filler is arranged at a position, corresponding to the upper part of the screen plate, in the shell; the gas escapes upwards, so that the gas returns to the upper part of the water body after reaching the bottom of the sewage, the circulation effect is achieved, and the mixing effect of the gas and the sewage is further improved; besides, the spray heads can rotate along with the hollow shaft, and the spray heads on the different vortex-shaped pipes are arranged in a staggered manner, so that the distribution density of the gas in the sewage water body can be improved, the mixing effect between the sewage and the gas is further improved, the biological treatment reaction speed of the sewage is prevented from being influenced, and the purification efficiency of the reactor is improved.

The invention relates to a local magnetothermal coupling biological rotating disc enhanced cold region sewage treatment method and system. The system comprises a reactor, a biological rotating disc for growing a biological membrane, a magnetic heat carrier, an alternating magnetic field generator and a motor for driving the biological rotating disc to rotate, the reactor comprises an air exposure area and a sewage area from top to bottom, a water inlet is formed in the lower part of the left side wall of the reactor, a water outlet flush with the water level of the sewage area is formed in the upper part of the right side wall, the reactor is further provided with vent holes, and the air exposure area is communicated with air through the vent holes; the biological rotating disc is partially immersed in the sewage area and partially exposed to the air exposure area in the radial direction; the air exposure area is located in the magnetic field action range of the alternating magnetic field generator, the magnetic heat carrier is arranged on at least one side of the biological rotating disc, and the magnetic heat carrier generates a magnetocaloric effect under the action of the magnetic field so as to increase the temperature of the biological membrane. According to the invention, the synergistic effect of precise heating of the biological membrane and the metabolic process of the biological membrane is realized, and the efficient and energy-saving sewage denitrification process at low temperature is realized.

The utility model relates to a heat preservation structure of a biological membrane filter tank, which comprises a tank body, a heat preservation framework matched with a tank opening in shape is fixedly arranged above the water surface of the tank body, a heat preservation film is covered above the heat preservation framework, and an air area for air circulation is formed between the heat preservation framework and the water surface. By adopting the scheme, the utility model provides the heat preservation structure of the biological membrane filter tank, which is stable in effluent quality.

The application belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mp-GC21, a precursor thereof and application. The amino acid sequence of the antibacterial peptide Mp-GC21 is shown as SEQ ID NO:1, wherein the C terminal is subjected to amidation modification, and two cysteines are connected through a disulfide bond; and the amino acid sequence of the precursor is shown as SEQ ID NO:3. The antibacterial peptide Mp-GC21 is separated from the flower frog, has broad-spectrum antibacterial activity, and has good bacteriostatic and bactericidal effects on standard strains and clinically derived drug-resistant strains of Acinetobacter baumannii, Escherichia coli and Staphylococcus aureus, and can target to destroy the cell membrane of bacteria, remove the biofilm and inhibit the formation of the biofilm. Moreover, the antibacterial peptide Mp-GC21 has good stability, does not have hemolytic activity, cytotoxicity and in-vivo toxicity, and is not easy to induce drug resistance of strains.

The application discloses a high-concentration sulfate radical acid mine water treatment method based on acid-resistant SRB biological cathode, which comprises the following steps: after the acid mine water is filtered through a grid, the acid mine water is fed into an adjusting tank; the wastewater in the adjusting tank is fed into a biological membrane electrochemical device to perform an electrochemical reaction; in an anode chamber, Fe 2+ in the wastewater is oxidized into Fe 3+ and releases electrons; in a cathode chamber, the acid-resistant SRB bacterial membrane loaded on the surface of a carbon felt electrode utilizes the transmitted electrons to reduce SO4 2‑ into S 2‑ ; CO2 micro-bubbles are fed into the liquid in the cathode chamber to react with S 2‑ to generate sulfur precipitate, and the mixed solution after the reaction is fed into a cyclone separator to realize gas-solid separation; Fe 3+ in the water in the anode chamber generates Fe(OH)3 precipitate through a hydrolysis reaction, the Fe(OH)3 precipitate is mixed with sodium silicate, and is calcined to be converted into alpha-Fe2O3 with magnetism. The method can effectively remove SO4 2‑ and recover iron mud.

This invention discloses a target-gated ratiometric pH sensor based on a dual CRISPR system of tetrahedral framework nucleic acids, belonging to the fields of biomedicine and nucleic acid nanotechnology. The sensor uses tetrahedral framework nucleic acids as a rigid scaffold, precisely assembling Cas12a, Cas13a, and their corresponding fluorescent reporter molecules in a 1:1 stoichiometric ratio. Their orthogonal pH responses form the basis of the ratiometric sensing. Target recognition-pH sensing logic gating is achieved through target-specific crRNA design. Cholesterol modification allows for stable anchoring on the lipid membrane surface. This invention also discloses the sensor's fabrication, membrane anchoring, pH monitoring, and target-gated function implementation methods. This sensor possesses advantages such as high-precision ratio measurement, accurate spatial arrangement, high specificity, stable membrane anchoring, and a wide pH response range, and can be used for precise monitoring of pH dynamics at biomembrane interfaces and during extracellular vesicle fusion.

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The utility model provides a sludge self-inoculation type bio-membrane reactor, which relates to the technical field of bio-membrane reactors and comprises a reactor, a storage tank and a clean water tank, the storage tank and the clean water tank are respectively arranged on the left side and the right side of the reactor, a packing area is arranged on the lower portion inside the reactor, and a lifting pump is arranged at the bottom inside the storage tank. A filler area is arranged in the reactor, a water inlet area is arranged at the lower part in the reactor, a bearing plate is arranged in the reactor below the filler area, the output end of the lifting pump is connected with the water inlet area through a connecting pipe, and an air blower is arranged at one side of the reactor; according to the utility model, continuous contact can be formed between inoculated sludge and biological stuffing, the contact time and the inoculation area are increased, the formation process of a biological membrane is accelerated on the basis of providing external oxygen supply and nutrition conditions, the formation time is shortened, the adhesion effect is optimized, and a good inoculation effect is achieved in the inoculation process of domestic sewage with a low carbon-nitrogen ratio.

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.

The invention discloses a recyclable climbing type growth robot based on a micro-structure biological membrane and a working method of the recyclable climbing type growth robot. The growth robot comprises a growth cabin and a growth main body, the growth main body is of a flexible tubular structure with two closed ends, the growth main body has a storage state and a growth state, and one end of the growth main body is stored in the growth cabin; during working, gas is introduced into the growth cabin to provide internal pressure, a direct-current motor is matched to drive a reel to jointly drive the growth main body to be turned outwards and extend out of an outlet of the growth cabin, a micro-structure biological membrane on the surface of the growth main body makes contact with a climbing surface to generate adhesive force, and the robot climbs and grows; after the task is completed, gas supply is stopped, the motor rotates reversely, the reel applies axial recovery tension to the growth main body, and the growth main body is wound and recovered into the growth cabin. Reliable climbing and recovery of the growth robot are achieved, and the application prospect is wide.

The invention discloses a microenvironment response type chessboard microneedle system and application thereof in treatment of drug-resistant bacteria infected wounds, and provides the microneedle system for solving the technical problems that in treatment of MRSA infected wounds, drugs are difficult to penetrate through wound surfaces and biological membrane barriers, the effective concentration of NO is difficult to maintain, and antibacterial-repair synergy is insufficient. The microneedle is formed by alternating hyaluronic acid and polyvinyl alcohol, ZCSO nano-enzyme and NO donor SNAP are loaded on the microneedle respectively, and the microneedle can penetrate through a physical barrier to accurately deliver functional components to a focus to achieve space targeting. The nidus microenvironment is triggered to release Cu < 2 + >, SNAP is catalyzed to continuously produce NO, time-space synchronization of NO and Cu < 2 + > is realized, and the NO gas therapy and copper-like death are used for synergistically resisting bacteria; se and Zn < 2 + > can relieve oxidative stress, regulate and control inflammation microenvironment and promote tissue regeneration. The system can efficiently remove MRSA and promote wound repair, provides a new strategy for treatment of drug-resistant bacteria infected wounds, and has a good clinical application prospect.

This application discloses an aquaculture wastewater treatment system, relating to the technical field of wastewater treatment. The system includes an equalization tank, a flotation unit, a biofilm tank, a sludge tank, and a dewatering unit. The equalization tank is used to homogenize the quality and quantity of the aquaculture wastewater, and its bottom is connected to the flotation unit via a pipe. A pipe is connected between the flotation unit and the biofilm tank for transporting the aquaculture wastewater after flotation, and a pipe is connected between the flotation unit and the sludge tank for transporting the flotated sludge. A pipe is connected between the biofilm tank and the sludge tank for transporting the aged biofilm. A pipe is connected between the sludge tank and the dewatering unit for transporting sludge, and the dewatered liquid obtained from the dewatering unit can be returned to the equalization tank. This application can effectively improve the treatment effect of aquaculture wastewater, thereby effectively reducing the environmental pollution caused by aquaculture wastewater discharge.

The invention discloses a traditional Chinese medicine composition for preventing and treating avian pathogenic escherichia coli as well as a preparation method and application thereof, and relates to the technical field of veterinary drugs. According to the invention, screening is carried out through subtraction genomics and reverse network pharmacology, and based on the compatibility theory of monarch, minister, assistant and guide and the traditional Chinese veterinary medicine and pharmacy differentiation theory, a traditional Chinese medicine composition, namely the radix angelicae and fructus forsythiae intestine health formula, for preventing and treating avian pathogenic escherichia coli is formed. According to the traditional Chinese medicine composition, fructus forsythiae and radix angelicae are used as monarch drugs, radix isatidis and clinopodium polycephalum are used as ministerial drugs, fructus aurantii immaturus, mint and plantain herb are used as adjuvant drugs, and liquorice is used as a conductant drug, so that the traditional Chinese medicine composition can inhibit reproduction of avian pathogenic escherichia coli, destroy formation of biological membranes of the avian pathogenic escherichia coli and relieve pathological injuries of diseased poultry caused by APEC; the traditional Chinese medicine composition has a good treatment effect on avian pathogenic escherichia coli.

The utility model discloses an aeration mechanism for sewage treatment, which comprises a longitudinally arranged aeration main pipe, and at least three groups of horizontally extending aeration branch pipes are distributed on the outer wall of the aeration main pipe along the axial direction at equal intervals; aeration holes which are distributed at equal intervals are formed in the bottom surface of the aeration branch pipe, and the tail end of the aeration branch pipe extends below the mounting position of the movable flow baffle; each flow baffle is transversely bridged between two adjacent aeration branch pipes, and the bottom edge of each flow baffle is matched with the outer diameter curved surface of the corresponding aeration branch pipe. When airflow is released from the aeration holes, the curved surfaces of the flow baffles guide bubbles to rise along a specific track, the bubble column concentration phenomenon formed by traditional vertical aeration is avoided, and the activity of a biological membrane in the edge area of the reactor is improved.

The application discloses corn silk glucan, a structure formula of which is [→4)-β-D-Glcp-(1→]n, wherein n is 6-60, and a molecular weight range is 1-9.8 kDa. By extracting effective components in corn silk, an extract is obtained, the extract is precipitated by 30-90% ethanol, corn silk crude polysaccharide is obtained, and after the corn silk crude polysaccharide is dissolved, the corn silk crude polysaccharide is sequentially subjected to biological membrane dialysis, ion exchange resin column and HPLC-ELSD separation and purification, and corn silk glucan is obtained. The corn silk glucan and zeaxanthin are compounded to form a glucan compound, the glucan compound can stabilize insulin and improve the activity of the insulin in mouse islet cells, and the glucan compound has 2-5 times stronger hypoglycemic activity than that of zeaxanthin alone, and therefore, the glucan compound has important significance for researching new hypoglycemic drugs or health-care food for assisting hypoglycemia.

The invention provides novel compounds of formula (I), stereoisomers and pharmaceutically acceptable salts thereof: (wherein: Q is a lipophilic, zinc chelating moiety which is selective for Zn2+ ions; L1 is a covalent bond or a C1-6 alkylene chain in which one or more -CH2- groups of the alkylene chain are optionally replaced by a group independently selected from -CO- and -NR4- (where R4 is H or C1-3 alkyl); Y is selected from the following groups: (II) and (III) (where each R5 is independently H or C1-3 alkyl; and R6 is H or C1-3 alkyl); L2 is a covalent bond or a C1-6 alkylene chain in which one or more -CH2- groups of the alkylene chain are optionally replaced by a group independently selected from -CO- and -NR7- (where R7 is H or C1-3 alkyl); R is -OH, -O-C1-6 alkyl, -O-(CH2)p-O-CO-C1-6 alkyl (where p is an integer of 1 or 2) or -O-CH(CH3)-O- CO-C1-6 alkyl; each R1 is independently selected from halogen and C1-3 alkyl; each R2 is independently selected from halogen and C1-3 alkyl; R3 is H or C1-3 alkyl; n is an integer of 0 or 1; and m is an integer of 0 or 1). The compounds according to the invention are selective zinc chelators that find use as adjuvants in the treatment of bacterial infections and / or bacterial biofilms that harbour such infections. For use in such treatment, the compounds are used in combination with an antibacterial agent, for example a β-lactam antibiotic. The invention further provides a triple combination therapy for use in the treatment of bacterial infections and / or bacterial biofilms which comprises co-administration of the compounds to a subject in combination with a β-lactam antibiotic and a serine β-lactamase inhibitor.

The present application belongs to the technical field of quorum quenching enzyme preparation, and particularly relates to a multi-target quorum quenching enzyme preparation and a preparation method and application thereof, such as being mainly used for inhibiting the virulence factors of Pseudomonas aeruginosa, and including acyl homoserine lactone acyltransferase AiiO protein and 3-hydroxy-4-oxoquinolone 2,4-dioxygenase AqdC protein, and the mass ratio of the two is 20:(1-25); such as being mainly used for inhibiting the virulence factors and the synthesis of biological membranes of Pseudomonas aeruginosa, and further including deferiprone, and the mass ratio of AiiO, AqdC and deferiprone is 20:(1-25):(0.695-2.78), the present application can target the Las, Rhl and PQS of Pseudomonas aeruginosa, the yield and stability of the prepared AqdC protein are both high, the two types of enzymes are used in combination after the regulation amount, and the virulence factors regulated by different quorum sensing pathways in Pseudomonas aeruginosa are effectively inhibited; the regulation amount of deferiprone is used in combination with the two types of quorum quenching enzymes, and the virulence and biological membranes of Pseudomonas aeruginosa can be effectively inhibited in a comprehensive manner.

The application discloses a kind of preparation methods of anaerobic self-chelation organic water-soluble fertilizer, belong to agricultural organic water-soluble fertilizer preparation technical field.The method includes: after being crushed and conditioned, organic waste is mixed with nano limited carrier with specific pore size and surface functional group, and biological membrane is constructed in anaerobic reactor;Subsequently, mineralization reaction is carried out, and self-chelation reconstruction program is automatically triggered by online monitoring short-chain fatty acid concentration, and endogenous metabolites and nutrient ions are directionally chelated and self-assembled in nano limited space under the guidance of carrier;Finally, after separation, sterilization and concentration, the finished product is obtained.The application prepares organic-inorganic composite nano fertilizer with average particle size of 80-150nm, chelated zinc ratio of ≥82% and chelated phosphorus ratio of ≥68% without relying on exogenous chelating agent, and the 30-day nitrogen and phosphorus leaching loss rate is less than 17.0% and 11.5%, which has good slow-release performance and agricultural yield-increasing effect, and provides a new technical approach for high-value resource utilization of organic waste.

The invention discloses an imidazolyl lipid assembly as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: mixing diphenyl phosphate, alcohol and pyridine, and heating for reaction to obtain alkyl phosphate; mixing N, N-diethylethylenediamine, 5-imidazole formaldehyde and a solvent, carrying out a heating reaction in a protective atmosphere, then adding the alkyl phosphate, and continuing the heating reaction to obtain an imidazolyl lipid molecule; dissolving the imidazolyl lipid molecules in an organic solvent to obtain a mother solution; the imidazolyl lipid assembly is obtained from the mother liquor through a film hydration method. The imidazole-based lipid assembly constructed by the invention can utilize the imidazole group to destroy the normal structure of bacteria under the condition of no antibiotic load, and utilizes the catalytic action of the imidazole group to complete the destroy of a biological membrane matrix and an inflammation activation medium, so that the synergism of antibiosis and anti-inflammation is realized, and the imidazole-based lipid assembly has the effect of buffering local acidic pH.

The invention discloses chitosan oligosaccharide separation and purification membrane equipment, and relates to the technical field of biological membrane separation equipment.The chitosan oligosaccharide separation and purification membrane equipment specifically comprises a rack, a pretreatment box is arranged in the rack in a sleeved mode, a fixed liquid guide pipe and a filter screen cylinder are arranged in the pretreatment box in a sleeved mode, and the fixed liquid guide pipe is arranged in the filter screen cylinder in a sleeved mode; the two ends of the filter screen cylinder are respectively sleeved with the top structure and the bottom structure of the pretreatment box in a penetrating manner. According to the biological membrane separation equipment, the arranged filter screen cylinder can perform static direct filtration or centrifugal filtration under the transmission of the power output component while downward flowing and conveying of to-be-treated liquid are not delayed, the use effect of filtration of the filter screen cylinder is fully improved, and the problem that the interior of the filter screen cylinder is blocked is solved. In the process that the filter screen cylinder is driven by the power output component to rotate, the multiple brush strips in the brush plate assembly are matched for synchronous operation, so that the multiple brush strips conduct anti-blocking brushing treatment on the inner wall of the filter screen cylinder in a passive mode.

The utility model discloses container type sewage treatment integrated equipment capable of being quickly installed, which relates to the technical field of sewage treatment and comprises a container, a rectangular box body is arranged in the container, a plurality of partition plates are arranged in the rectangular box body, and the partition plates are arranged in the rectangular box body. The rectangular box body is divided into a sedimentation tank, an anaerobic tank, an aerobic tank and a biological membrane treatment tank by the partition plates; according to the utility model, the sedimentation tank, the anaerobic tank, the aerobic tank and the biological membrane treatment tank are integrated and are mounted in the container, so that sedimentation, anaerobic treatment, aerobic treatment, biological membrane treatment and dosing treatment can be realized; the wastewater treatment effect is effectively improved, and the water quality after wastewater treatment is improved.

The utility model provides a biofilm process integrated sewage treatment device. The biofilm process integrated sewage treatment device comprises an anoxic reaction assembly, a pipeline communication assembly, a convection reactor and a sedimentation clarification tank, the anoxic reaction assembly is connected with the convection reactor through the pipeline communication assembly, and the convection reactor is communicated with the precipitation clarification tank through the siphon pipeline assembly; the bottom of the high-level water tank is arranged above the convection reactor, one end of the siphon pipeline assembly is arranged in the convection reactor, and the other end of the siphon pipeline assembly is arranged in the sedimentation clarification tank. The fluidized filler is filled in a partitioned manner, so that the fluidization effect is achieved, and the problems that the filler is easy to block and integrally gathers and escapes in the existing SBBR and MBBR processes are effectively solved.

The invention relates to the technical field of bioelectricity signal monitoring, in particular to an implantable biofilm wireless monitoring sensor and system based on AgCl / Ag impedance conversion, and the system comprises an anode integration module, a cathode verification module, a frequency analysis module, a closed-loop regulation and control module and a packaging state evaluation module. According to the method, by directly collecting the current of the closed-loop circuit of the implant and the charge transfer resistance of the biological membrane, original interface information is provided for subsequent analysis, the change rate of the resistivity of the silver chloride is detected, the resonant frequency deviation of the silver / silver chloride antenna is synchronously measured, a high-sensitivity anomaly recognition mechanism is constructed, and the early-warning capability of interface instability or material degradation in the early stage is improved; extracting a circuit phase angle and an antenna Q value after abnormity identification, calculating a frequency compensation coefficient by applying frequency domain least square fitting, controlling a silver chloride / silver conversion rate, optimizing wireless signal transmission, monitoring a packaged water vapor transmission rate and an ion permeation flux, and ensuring long-term reliability of implanted equipment.

The invention relates to the technical field of sewage treatment integration, in particular to a low-carbon intelligent household rural sewage treatment device which comprises an integrated tank, a plurality of partition plates are arranged in the integrated tank, and the integrated tank is sequentially divided into a regulating tank, an anaerobic tank, an aerobic tank and a sedimentation tank by the partition plates. Separating plates are fixedly connected in the regulating tank, flow guide pipes are arranged on the plurality of separating plates, two adjacent tanks are communicated through the flow guide pipes, a biological membrane assembly is arranged in the aerobic tank, an aeration assembly is arranged on the biological membrane assembly, and a driving assembly is arranged on the aeration assembly; a set of low-carbon, self-sustaining and intelligent composite aeration system is constructed by integrating a wind energy gathering and guiding type driving plate, a wind energy linkage stirring mechanism and a kinetic energy recovery type piston gas pumping assembly, the advantage of solar driving is reserved, meanwhile, the windy characteristic of cloudy and rainy days is fully utilized, energy complementation and function redundancy are achieved, and the energy utilization rate is increased. The continuous and stable dissolved oxygen supply of the aerobic tank under various weather conditions is ensured.

The invention relates to a closed-loop recovery and biological treatment system for biodegradable cooling liquid, and relates to the technical field of sewage treatment, and the system comprises a waste liquid chamber, a first treatment chamber, a buffer chamber and a second treatment chamber which are communicated in sequence. The waste liquid chamber receives cooling liquid waste liquid; a suspended filler and a first microbial flora are arranged in the first treatment chamber; a filtering mechanism is arranged in the buffer chamber and is divided into a first area and a second area; a first biological membrane is arranged in the second treatment chamber, a second microbial flora grows in the first biological membrane, and the second biological membrane divides the chamber into a liquid mixing area and a water producing area. According to the invention, through coupling of grading biological treatment and membrane separation, efficient and stable removal of organic components in the waste cooling liquid is realized.

The application discloses a kind of biological hybrid nanoscale enzyme robot pills, with multi-mode regulation intestinal redox homeostasis and dysbiosis in inflammatory bowel disease, steps are as follows: step one, using zinc nitrate, acetylacetone iron and methanol and other drugs synthesis metal organic framework precursor, then calcination obtains iron single atom nanoscale enzyme;Step two, cultivate enrichment long bifidobacterium and human induced pluripotent stem cells, and extract the exosome or outer vesicle membrane of both respectively;Step three, nanoscale enzyme and probiotic vesicle membrane and stem cell exosome are co-extruded, and biological membrane-nanoscale enzyme composite robot is prepared;Step four, the prepared biological membrane-nanoscale enzyme composite particle is encapsulated in magnetic response pill, and engineering biological hybrid nanoscale enzyme robot pill is formed.Engineering biological hybrid nanoscale enzyme robot pill can be targeted to stay in intestinal inflammatory site under the control of rotating magnetic field after entering the intestinal tract of organism, then promote nanoscale enzyme release and enhance enzyme activity under the action of pulse magnetic field, so as to improve the treatment effect.Engineering biological hybrid nanoscale enzyme robot pill has biocompatibility and treatment safety, and has wide application prospect in the field of treating digestive tract inflammation.

The invention provides a Pt / PEDOT composite modified carbon-based material needle-shaped electrode in-vivo dissolved oxygen electrochemical sensor as well as a construction method and application thereof, and belongs to the technical field of medical biology. According to the in-vivo dissolved oxygen electrochemical sensor, a carbon-based material microneedle type electrode is modified by electrochemical deposition of platinum nanoparticles by using a chloroplatinic acid hexahydrate solution and depending on a time current method, and poly (3, 4-ethylenedioxythiophene) is generated by direct electro-polymerization on the surface of the Pt-modified microneedle electrode through an electrochemical constant current method. And forming uniform PEDOT (poly (3, 4-ethylenedioxythiophene)) film coated and modified platinum nanoparticles on the microneedle electrode. The composite modified carbon-based material is used for replacing precious metal to reduce cost and improve biocompatibility, low-oxygen sensitivity is optimized by means of composite modification, in-vivo protein adsorption and biological membrane coverage are resisted through anti-pollution surface modification, and therefore the defects are overcome, and monitoring of in-vivo tissue oxygen partial pressure is achieved.