815 results about "Biological membrane" patented technology

The invention discloses manganese and cerium co-doped modified sodium niobate, which is prepared from Nb2O5, MnO2, CeO2 and sodium hydroxide. The invention further discloses magnesium-based bone cement with the sonodynamic / nano-enzyme antibacterial function and the piezoelectric osteogenesis function. The magnesium-based bone cement is prepared from CaHPO4, NaH2PO4, MgO powder, hydroxyapatite and manganese-cerium co-doped modified sodium niobate. The magnesium-based bone cement with sonodynamic / nano-enzyme antibiosis and piezoelectric osteogenesis provided by the invention has piezoelectric enhanced sonodynamic and nano-enzyme synergistic antibacterial activity and piezoelectric osteogenesis activity, effectively removes bacteria / biological membranes, realizes combination of antibiosis and bone repair under different ultrasonic powers, effectively treats infectious bone defects, and has a good application prospect. The treatment effect of the MPC basal bone repair material is obviously improved.

The embodiment of the invention relates to electrochemical enhanced biological integrated intelligent regulation and control equipment for treating organic wastewater. The electrochemical enhanced biological integrated intelligent regulation and control equipment comprises an electrochemical enhanced biodegradation module and an intelligent control system, the electrochemical enhanced biodegradation module comprises a porous membrane electrode assembly, a power supply control system, an electrolyte adding system, a fixed bed biological membrane, an aeration system and a carbon source adding system; the intelligent control system comprises a data acquisition and remote monitoring module and a PLC (Programmable Logic Controller); the data acquisition and remote monitoring module acquires parameters such as COD (Chemical Oxygen Demand), dissolved oxygen concentration, ammonia nitrogen, total nitrogen and conductivity of the electrochemical enhanced biodegradation module and transmits the parameters to the PLC; and the PLC receives the parameters, and automatically adjusts one or more of voltage, current density, aeration rate and carbon source dosage based on a preset model established by a support vector regression and neural network machine learning algorithm. The intelligent regulation and control equipment can keep an optimal treatment state under different wastewater characteristics and load conditions, and has strong adaptability to environment or load fluctuation.

The invention relates to a continuous flow AOA whole-course anaerobic ammonia oxidation self-enrichment enhanced denitrification system and method, and the system comprises a front anoxic tank, an aerobic tank and a rear anoxic tank which are connected in series, and is filled with a biological filler; the monitoring aeration device comprises an ammonia nitrogen detector and an aeration unit which are connected with the aerobic tank; the reflux device is used for communicating a reflux outlet of the rear anoxic tank with water distribution of the front anoxic tank; and the PID control unit is connected with the monitoring aeration device, the backwashing control valve and the reflux device. The method comprises the following steps: sewage flows into the front anoxic tank, the aerobic tank and the rear anoxic tank; regulating and controlling the reflux ratio to domesticate the biological membrane of the aerobic tank; the ammonia nitrogen concentration of effluent of the aerobic tank is detected in real time through an ammonia nitrogen detector, and the PI D control unit dynamically adjusts the aeration rate of the aerobic tank according to the ammonia nitrogen concentration value and a preset target value, so that the aerobic tank and the rear anoxic tank form an anaerobic ammonium oxidation bacteria self-enrichment environment; the backflow device is used for enabling effluent of the rear anoxic tank to flow back to the front anoxic tank according to a preset proportion, so as to form a whole-process anaerobic ammonia oxidation self-enrichment environment.

The invention relates to the technical field of data monitoring analysis, in particular to a background monitoring system based on a beverage dispenser, which comprises a data acquisition module for calculating a dynamic deviation coefficient between a current ratio and a standard ratio; the compensation decision module is used for outputting flow compensation parameters of each channel based on the dynamic deviation coefficient; the regulation and control module adjusts the opening degree of the electromagnetic valve based on the flow compensation parameters; the uniformity extraction module is used for collecting the adjusted vibration frequency spectrum of the mixing bin and extracting a target frequency band energy value as a mixing uniformity index; and the risk prediction module is used for triggering a biological membrane risk prediction model when the mixing uniformity index is lower than a uniformity threshold value. According to the method, the problem of non-uniform mixing is found in time, early warning and optimization adjustment are triggered, and the matching problem and biological membrane generation caused by non-uniform mixing are effectively avoided.

The invention provides a tumor cell exosome, an anti-tumor immune drug delivery system and a preparation method and application of the anti-tumor immune drug delivery system, the tumor cell exosome is derived from starved and stimulated tumor cells, the tumor cell exosome is coated with nano drug particles for delivery, and the exosome has the effects of enhancing immune cell infiltration and remodeling an immune microenvironment; due to the homing effect of the exosome, the medicine and the exosome are more easily accumulated in the tumor, and the targeting property is improved; due to coating and camouflage of the biological membrane of the exosome membrane, the exosome membrane is prevented from being recognized, attacked and removed by an organism, and the biological safety is improved, so that the exosome and the nano-drug act on the tumor together to achieve a synergistic effect.

The invention relates to the technical field of water treatment equipment, in particular to an ultrasonic water treatment equipment control method and system based on variable-frequency vibration waves. According to the method, based on preset fluid working condition parameters, ultrasonic frequency conversion vibration wave signals covering multiple frequency bands are dynamically generated, and a vibrator array is driven to generate a composite sound field; a cavitation effect and an activation effect are synchronously excited in a fluid medium through variable-frequency vibration wave signals, so that physical form depolymerization and surface charge distribution change of scale forming substances occur; a shearing effect is formed on a fluid-pipe wall boundary layer, an attached state biological membrane structure is stripped, and the microscopic binding force of a crystallized scale body is loosened; monitoring the dispersion degree of scale-forming substances in the fluid and the state of a boundary layer, and adjusting the frequency band combination and energy distribution of variable-frequency vibration waves to maintain scale inhibition; and continuously optimizing the frequency conversion strategy and the sound field intensity according to the feedback data of the scale inhibition maintenance state. Through intelligent multi-band frequency conversion control of the ultrasonic water treatment equipment, efficient and environment-friendly water treatment and scale prevention effects are realized.

The invention discloses a bullfrog three-dimensional breeding system and an accurate feeding control method, and the bullfrog three-dimensional breeding system is characterized in that the bullfrog three-dimensional breeding system comprises a modular breeding unit, a gradient water level adjusting device and an interlayer isolation water circulation system, the three-step type three-dimensional framework is divided into a bottom layer tadpole pond, a middle layer froglet net cage and a top layer adult frog breeding bin, a control module is installed on each layer, and anti-escape assemblies are installed on the middle layer froglet net cage and the top layer adult frog breeding bin; the gradient water level adjusting device comprises a bionic step and a water level sensor which are arranged and installed, and the water level gradient adjusting and behavior inducing functions are achieved through engineering design. The interlayer isolation water circulation system comprises a distributed sensor, a UV sterilization and biological membrane filtration dual purification assembly and an adjustable air curtain, the adjustable air curtain forms a directional barrier between different layers of the three-dimensional culture system by dynamically regulating and controlling airflow, and independent environmental parameters of each layer are maintained.

A working wire for a biological sensor is disclosed. The working wire includes a substrate comprising cobalt-chromium (Co—Cr) alloy or Nitinol alloy, a platinum layer comprising platinum on the substrate, and a membrane layer comprising a biological membrane applied over the platinum layer.

The invention provides a degradable biological membrane and a preparation method thereof. The degradable biological membrane is prepared from the following raw materials in parts by weight: 60-70 parts of PBAT, 30-40 parts of PLA, 5-10 parts of microcrystalline cellulose composite modified particles, 0.5-2 parts of a chain extender, 1-2 parts of a coupling agent, 0.5-1 part of an anti-hydrolysis agent and 0.5-1 part of an antioxidant. The degradable biological membrane is obtained through the working procedures of mixing, extrusion granulation, curtain coating cooling, two-way stretching and the like. Wherein the microcrystalline cellulose is modified through the procedures of carboxylation, cross-linking, monohydroxyl end-capping grafting and the like at a specific degree to prepare composite modified particles, so that the degradable biological membrane has good mechanical properties and waterproof and breathable functions.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention discloses an ebbuselenium derivative, a pharmaceutical composition and application of the ebbuselenium derivative. The ebbeselenium derivative provided by the invention has the characteristic of inhibiting PPK activity, reduces the polyphosphoric acid (polyP) level of bacteria, reduces the formation of biological membranes, reduces the athletic ability of the bacteria, reduces the generation of virulence factors, can also enhance the sensitivity of the bacteria to antibiotics, and can be used for preparing a medicine for preventing and treating the diseases, such as the diseases, the pests and the like. Therefore, the compound is used for preventing and treating bacterial infection diseases.

The present application provides a preparation method for a biological membrane, and a product and an application thereof. The preparation method for the biological membrane comprises the following steps: (1) treating animal cavity tissues by using a collagenase inhibitor; (2) removing a membrane layer which accounts for more than 40% of the total fat content of the animal cavity tissues; (3) using a first enzyme solution to treat a product obtained in step (2); (4) using an alkali solution to treat a product obtained in step (3); (5) using a decellularized solution to treat a product obtained in step (4); (6) using a degreasing fluid solution to treat a product obtained in step (5); (7) using a second enzyme solution to treat a product obtained in step (6); and (8) using supercritical carbon dioxide to clean a product obtained in step (7) to obtain a biological membrane. In the present application, the integrity of a multi-layer space structure, elastic fibers and a collagen network of the biological membrane can be reserved to a great extent, the mechanical strength is high, residues of organic matters and reagents in the product can be removed, and the tissue regeneration inducing effect of the product is better.

The invention discloses sewage purification equipment based on a biological membrane combined process and a purification method thereof.The equipment comprises a main body unit, a cleaning unit, a water isolation unit and a vibration unit, the main body unit comprises a sewage purification box, a biological membrane layer fixedly connected with the interior of the sewage purification box, an activated carbon adsorption layer and a filtering layer; the cleaning unit is located in the sewage purification box and used for cleaning the filtering layer, the water isolation unit is arranged in the cleaning unit, fixedly connected with the inner top wall of the sewage purification box and used for isolating sewage and avoiding hindering cleaning of the cleaning unit, and the vibration unit is connected with the cleaning unit and the water isolation unit. According to the invention, when the scraping plate is used for scraping impurities, the sewage purification operation does not need to be interrupted, and the impurities are not easy to flow everywhere along with water flow when the impurities are scraped, so that the impurity cleaning effect can be improved, in addition, when the impurities are scraped to the impurity collecting box, the impurities can be ensured not to be attached to the scraping plate, and the impurity cleaning effect is further improved.

The invention provides a nano-drug based on atomic layer deposition and a preparation method of the nano-drug, mesoporous silica is taken as a carrier, bimetallic nanoparticles are precisely deposited through ALD, and chemotherapeutic drugs and antibacterial components are loaded by combining amination and targeted PEG modification, so that the following functions are realized: (1) H2O2 in a tumor microenvironment is catalyzed to generate reactive oxygen species (ROS); removing fusobacterium nucleatum and damaging a biological membrane of the fusobacterium nucleatum; (2) GSH is consumed through Fenton reaction, and tumor drug resistance is reversed; and (3) the drug is released in pH response, and tumor cells are accurately killed. The invention further provides application of the nano-drug based on atomic layer deposition in treatment of related drug-resistant colorectal cancer induced by fusobacterium nucleatum, the process is controllable, the biocompatibility is excellent, the treatment effect on the drug-resistant colorectal cancer is remarkably improved, and the nano-drug has wide clinical application prospects.

The invention discloses a Fe / C loaded membrane module, a PN / A-MABR autotrophic nitrogen removal device, a preparation method and a sewage treatment method, and belongs to the technical field of sewage treatment. According to the invention, the problem that the treatment effect is influenced by NO3 <->-N accumulation in the existing membrane aeration coupling partial nitrification-anaerobic ammonia oxidation process is solved. Comprising a frame and a membrane body attached to the outer portion of the frame, the membrane body comprises a hydrophobic organic membrane layer, an iron-carbon material layer and a biological membrane layer which are sequentially arranged, and the hydrophobic organic membrane layer is attached to the outer portion of the frame. The iron-carbon material is added between the hydrophobic organic membrane layer and the biological membrane layer, the iron-carbon micro-electrolysis process is coupled with the dissimilatory process of nitrate generated by microbial metabolism, the removal of NO3 <->-N generated by anaerobic ammonia oxidation is enhanced, and the total nitrogen removal efficiency is improved.

The utility model discloses a membrane aeration bio-membrane reactor convenient to clean, and relates to the technical field of sewage treatment. Comprising a shell, a reaction chamber and a cleaning chamber are arranged in the shell, a dividing body and a horizontal reaction body are arranged between the reaction chamber and the cleaning chamber, the reaction body is in a hollow cylindrical shape, two rotating grooves matched with the reaction body are formed in the dividing body, and the bottom face of the reaction body is rotationally and hermetically connected with the inner wall of the shell. The reaction body is in sliding sealing connection with the segmentation body, the reaction body comprises a fixed block and membrane assemblies, the fixed block coincides with the projection of the segmentation body in the vertical direction, and the membrane assemblies are arranged on the two sides of the fixed block; a first liquid inlet is formed in the end, away from the cleaning chamber, of the reaction chamber, and a first liquid outlet is formed in the end, located in the hollow part in the reaction body, of the reaction chamber and communicates with the outside. According to the membrane component cleaning device, the influence on the working efficiency of the membrane component during cleaning is greatly reduced while the membrane component is conveniently cleaned by a worker, and the sewage treatment efficiency is ensured.

The invention discloses a self-cleaning composite piezoelectric ceramic membrane as well as a preparation method and application thereof, and belongs to the field of composite ceramic membranes. The technical problem that an existing ceramic membrane separation technology is poor in biomembrane pollution resisting effect is solved. According to the preparation method, the barium titanate ceramic membrane is firstly prepared to serve as the base membrane, then the copper oxide one-dimensional nanostructure is loaded on the piezoelectric ceramic substrate, and the base membrane has a large membrane surface area and can be combined with more catalysts, so that more active sites are provided for catalytic reaction; according to the composite membrane, the hydrophilicity, the anti-pollution performance and the piezoelectric catalysis self-cleaning performance of the membrane are remarkably improved, and pollutants in water can be quickly and effectively separated, so that the flux and the anti-pollution performance of the membrane are improved.

The invention discloses a preparation method and application of pH-responsive double-synergistic-therapy hydrogel. The hydrogel is mainly prepared from oxidized fucoidin (OFU), carboxymethyl chitosan (CMCs), zinc peroxide / copper nanoparticles (ZnO < 2-Cu >) and arginine (L-ARG). Under a gastric acid condition, the hydrogel generates H2O2 through zinc peroxide, copper ions catalyze H2O2 through a Fenton-like reaction to generate OH <->, arginine can catalyze H2O2 to generate NO, and the copper ions and the arginine act together to destroy a helicobacter pylori biological membrane and kill bacteria. The hydrogel has good injectability, self-healing property and adhesivity, is beneficial to intragastric injection application and can be adhered to the stomach, and the administration concentration of an infected part is improved; the antibacterial effect is generated only under the gastric acid condition, the helicobacter pylori biological membrane can be destroyed, and the helicobacter pylori antibacterial agent can be applied to the helicobacter pylori which is difficult to eradicate in the stomach of the human body.

The invention provides a recombinant chicken antibacterial peptide aiming at drug-resistant staphylococcus aureus, and belongs to the technical field of veterinarians. The recombinant chicken antibacterial peptide is expressed through genetic engineering recombinant escherichia coli. Three natural chicken antibacterial peptide active regions are fused, and two disulfide bonds are introduced to stabilize the structure of the recombinant chicken antibacterial peptide and enhance the affinity of the recombinant chicken antibacterial peptide to staphylococcus aureus outer membrane protein. The minimum inhibitory concentration of the recombinant chicken antibacterial peptide to the drug-resistant staphylococcus aureus is obviously lower than that of three natural chicken antibacterial peptides, and the formation of a biomembrane of a USA300 strain of the drug-resistant staphylococcus aureus can be thoroughly inhibited when the minimum inhibitory concentration is 8 mu g / mL. The recombinant chicken antibacterial peptide has a good antibacterial effect on different drug-resistant staphylococcus aureus separated from a chicken house, and can effectively solve the infection problem of the drug-resistant staphylococcus aureus in the chicken house.

The invention relates to the technical field of nano-drug presentation systems, in particular to a nanoparticle for synergistically promoting hepatoma ferroptosis based on mesoporous manganese dioxide, salazosulfapyridine and a tumor cell biological membrane as well as a preparation method and application of the nanoparticle. The nanoparticle in the scheme comprises mesoporous manganese dioxide which is modified with a tumor cell membrane on the surface and loaded with salazosulfapyridine. According to the technical scheme, the nanoparticles can effectively induce hepatoma cell ferroptosis through a multi-target strategy. The salazosulfapyridine and the mesoporous manganese dioxide have a synergistic effect to enhance the ferroptosis effect; the tumor cell biological membrane has homologous targeting property, so that the accumulation capacity of the nanoparticles in liver cancer tissues is remarkably improved; the nanoparticle provided by the invention not only can be used for treatment, but also can monitor the change in the treatment process in real time. According to the technical scheme, the technical problem that a nano-drug presentation system for effectively inducing ferroptosis aiming at multiple target spots is lacked in the prior art can be solved, and the technical scheme has important significance in improving the survival rate and the life quality of liver cancer patients.

The invention relates to the field of pharmacy, and discloses a Chinese herbal medicine and marine extract combined antibacterial and anti-inflammatory pharmaceutical composition which comprises the following components in parts by weight: 5-10 parts of baicalin extract; 3 to 7 parts of an andrographolide extract; 2-5 parts of sulfated brown algae polysaccharide; 0.2 to 1 part of sponge extract; wherein the baicalin extract is derived from roots of scutellaria baicalensis and is obtained by extracting with an ethanol-water mixed solvent; the andrographolide extract is derived from the whole herb of andrographis paniculata and is obtained by extracting with an ethanol-water mixed solvent; the sulfated fucoidan is derived from fucoidan and is prepared by enzymolysis and alcohol precipitation methods; the sponge extract is derived from sponge and is obtained by organic solvent extraction, separation and purification. By adopting the technical scheme of synergistically compounding the Chinese herbal medicine active ingredients and the marine extract, the technical effects of destroying a biological membrane barrier and removing stubborn infection lesions in treatment of bacterial vaginitis, candida vaginitis associated biological membrane infection and cervicitis are achieved.

The invention relates to the technical field of polypeptides, and discloses a soybean polypeptide with an antibacterial function and a preparation method thereof.The soybean polypeptide with the antibacterial function is obtained by adding soybean polypeptide, quaternized cholic acid and modified chitosan into N, N-dimethylformamide and stirring for reaction. A chitosan group, a quaternary ammonium salt group, an imidazole group and a cholic acid group contained in the soybean polypeptide with the antibacterial function jointly form an antibacterial system, and a good antibacterial effect is achieved; wherein the chitosan group can destroy bacterial cell walls to death bacteria, so that the antibacterial effect is achieved, and the cholic acid group also has a relatively good antibacterial effect; the imidazole group rapidly kills bacteria by destroying bacterial cell membranes, affecting bacterial metabolism and inhibiting formation of biological membranes, a good antibacterial effect is achieved, quaternary ammonium salt is adsorbed to the negatively charged bacterial cell membranes through the cationic characteristics of quaternary ammonium salt, the cell membranes are broken, and therefore the bacteria are rapidly killed.

The invention discloses a preparation method of photo-thermal-MMP dual-response matrix hydrogel and application of the photo-thermal-MMP dual-response matrix hydrogel in diabetic wound repair, and belongs to the technical field of biological medicine. According to the present invention, the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is composed of an amnion source photo-crosslinked matrix hydrogel, curcumin-loaded ZIF-8 nanoparticles and MMP2 peptide modified polydopamine, and the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is obtained; the ZIF-8 nanoparticles decline in an acid environment to release zinc ions, destroy bacterial cell membranes, enhance the permeability of a biological membrane and cooperatively kill drug-resistant bacteria in combination with a photothermal effect, Cur is loaded through ZIF-8 to form Cur-coated ZIF-8, then a Cur-coated ZIF-8-coated MMPDA / dAMG double-drug-loading system is constructed through an MMPDA medium, and a photothermal antibacterial, anti-inflammatory and regeneration-promoting multi-mode therapy is formed for a wound surface in the acid environment. Therefore, wound healing is accelerated.

The invention discloses a device and process for treating pharmaceutical wastewater through an internal electrolysis method. The device comprises a pretreatment unit, an internal electrolysis reaction unit, a precipitation separation unit, a pH adjusting unit and a control system which are sequentially connected. The internal electrolytic reaction unit comprises a reaction tower body, the top of the reaction tower body is provided with a water inlet, and the bottom is provided with a water outlet; a supporting layer, an iron-carbon micro-electrolysis filler layer, a catalytic oxidation layer and a biological membrane layer are sequentially arranged in the reaction tower body from bottom to top, the iron-carbon micro-electrolysis filler layer comprises an iron-carbon composite filler, and the mass ratio of iron to carbon in the iron-carbon composite filler is (1: 1)-(3: 1). The internal electrolysis reaction unit with a multi-level filling structure is adopted, iron-carbon micro-electrolysis, catalytic oxidation and biodegradation are organically combined to form a synergistic effect, the removal efficiency of refractory organics in the pharmaceutical wastewater is remarkably improved, and the COD removal rate can reach 80% or above.

The invention relates to the technical field of water environment monitoring, and discloses a water environment monitoring device and a detection method thereof, the device comprises a floating seat and a telescopic structure, and the bottom of the floating seat is provided with a liftable monitoring mechanism through the telescopic structure. By means of lifting adjustment of the monitoring mechanism, lifting at different water depth positions can be achieved so as to meet the monitoring requirements for different depths of a water body; a water quality sensing structure is mounted in the connecting cylinder, and a sensing probe of the water quality sensing structure is positioned in the monitoring cylinder and cooperatively works with an optical sensing structure in the monitoring cylinder to monitor a water body flowing through the monitoring cylinder in real time; a rotating impeller in the monitoring cylinder is driven by rotation of the rotating impeller to drive a reciprocating scraper to reciprocate, so that a sensing probe of the water quality sensing structure is scraped and cleaned, and attached biological membranes or sediments are removed; and meanwhile, the impeller is rotated to drive the cleaning piece to clean the optical detection area of the optical sensing structure, so that the accuracy and definition of optical detection are ensured.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The invention discloses a hydrogel microneedle patch and a preparation method and application thereof.The hydrogel microneedle patch is characterized in that a gel main body is obtained by mixing PEG600 and PEG1000 according to the mass ratio of 3: 4, erythromycin, vaccarin and 7-demethylated corticin are loaded, a temperature response type gel microneedle is prepared, DG is in a solid needle shape at the room temperature, and the temperature response type gel microneedle patch is a hydrogel microneedle patch. Under the action of external force, the medicine can penetrate through a biological membrane secreted by bacteria and then is quickly melted into liquid by virtue of body temperature, and loaded medicine is released; in the invention, the wound healing is promoted through the synergistic effect between the hydrogel and the medicine. The hydrogel microneedle patch prepared by the invention can remarkably promote rapid healing of a staphylococcus aureus infected wound surface and can remarkably promote rapid healing of a back wound surface of a diabetic rat.

The invention relates to the technical field of water pollution treatment equipment, and discloses glyphosate production sewage treatment equipment based on biological treatment.The glyphosate production sewage treatment equipment based on biological treatment.The glyphosate production sewage treatment equipment based on biological treatment.The glyphosate production sewage treatment equipment based on biological treatmentcomprises a treatment tank, a water distributor fixedly arranged at the top of an inner cavity of the treatment tank and a supporting ring rotationally arranged in the middle of the inner cavity of the treatment tank; a water outlet is formed in one side of the bottom of the treatment tank in a communicating manner, a biological membrane is mounted on the inner side of the supporting ring, and iron particles are mounted in the biological membrane in an embedded manner; the response characteristic that iron particles are embedded in an elastic biological membrane is utilized, local deformation of the biological membrane is induced through attraction of an electromagnet, membrane holes generate a stretching effect, blocking substances such as colloidal substances and flocculates attached to the membrane holes are effectively loosened and stripped, and the blocking substances are effectively removed by combining rotation of the biological membrane and dynamic cleaning of the water spraying assembly. The double blockage removal mechanism of physical deformation and hydraulic scouring is achieved, and compared with a traditional static cleaning mode, the blockage removal efficiency is higher.

The invention discloses a frontalon tooth healing targeting nano preparation and a preparation process thereof, belongs to the technical field of nano medicines, and aims to solve the problems that the natural regeneration capacity of teeth is limited and the combination of ethnic drugs and modern biotechnology is caused due to the lack of a targeting inhibition means for USAG-1. Comprising an anti-USAG-1 monoclonal antibody, ethnic drug components and a nano-carrier, the anti-USAG-1 monoclonal antibody is connected to the surface of the nano-carrier through covalent bonds, the ethnic drug components are loaded in the nano-carrier through physical action, and the nano-carrier is a polylactic acid-glycolic acid copolymer or chitosan; the anti-USAG-1 monoclonal antibody is used as a targeting ligand, is high in targeting property, can accurately reach a tooth focus, improves the drug utilization rate, enhances the curative effect, integrates multiple ethnic drug components, exerts a synergistic effect, can increase the contact area between the ethnic drug components and a biological membrane, promotes the absorption and transport of the drug, and improves the bioavailability of the drug. And the medicine can better play a treatment role.

The invention belongs to the technical field of cell engineering and biochemical detection, and particularly relates to an erythrocyte membrane with a complete structure and a preparation method and application thereof. The red blood cells are split by limiting the components of the release liquid, the conditions are mild, protein components such as hemoglobin in the red blood cells can be released, the cell attributes are removed, the integrity of the internal skeleton structure and the activity of the membrane surface antigen are reserved, the complete structure of the red cell membrane is kept, meanwhile, the key blood group antigen on the surface is reserved, and the effect is good. The problem of antigenicity reduction caused by erythrocyte membrane fragmentation is avoided. After the erythrocytes are lysed, the nanoparticles are coupled to the surface of the erythrocyte membrane, so that the agglutination reaction of the erythrocyte membrane under the induction of the antibody can be visualized. The engineering red blood cell biological membrane is preserved by adopting a fixed program, so that the damage of ice crystals to the engineering red blood cell biological membrane can be effectively avoided, the antigenicity of the membrane is not influenced, the membrane can be preserved for a long time at normal temperature, and the shelf life can be prolonged to two years or more.