886 results about "Body fluid" patented technology

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

The present invention relates to the field of tissue-derived cell identification, in particular to a method for identifying tissue-derived cells in the body fluid based on single-cell sequencing technology. In the present invention, on the basis of high-throughput single-cell RNA sequencing data of cell samples obtained from body fluids, by means of reference component analysis (RCA), expression of known tissue-related marker genes, and a tissue-derived cell prediction model constructed based on logistic regression, the specific identification of tissue-derived cells in body fluids is achieved.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

The invention provides an intermittent detection method and device for body fluid parameters and a related system.The method is applied to a body fluid parameter detection system, the system comprises an infusion tube, a detection module, an extraction and injection device, a liquid path switch and a flushing device.The method comprises the steps that the liquid path switch is controlled to execute a closing action, and the liquid path switch is controlled to close the infusion tube; controlling the extraction and injection device to extract a preset first volume of target body fluid from a preformed hole of a target user into the infusion tube, controlling the detection module to detect parameters of the target body fluid when the target body fluid in the infusion tube is detected to pass through the detection module, obtaining the parameters of the target body fluid, controlling the liquid path switch to execute an opening action, and controlling the liquid path switch to execute a closing action; and controlling the flushing device to inject a preset second volume of functional liquid into the infusion tube, and controlling the extraction and injection device to enable the target body fluid to flow back to the target user when the functional liquid in the infusion tube is detected to pass through the detection module. When blood gas parameter detection is carried out, blood waste and detection cost are reduced.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.

Doubly labeled water with enhanced protocol. One embodiment is a method including providing, to a user, a doubly labeled water (DLW) dose for the user to ingest, the DLW dose including deuterium and oxygen-18, wherein an amount of the deuterium is less than 0.12 grams per kilogram (g / kg) of body water of the user, and wherein an amount of the oxygen-18 is less than 0.18 g / kg of body water of the user. The method also includes receiving, from the user, a non-cooled shipment of urine samples collected in connection with ingestion of the DLW dose, wherein the urine samples remain uncooled after collection and during transit for a period of up to 24 days. The method further includes processing the urine samples with a liquid water isotope analyzer to determine one or more metabolic parameters of the user.

The invention discloses a self-breaking outer drainage tube, and relates to the technical field of medical instruments, the self-breaking outer drainage tube comprises a tube body, and the tube body comprises a drainage part, a breaking part, a leading-out part and a puncture part; the drainage part and the fracture part are both made of degradable materials; the hole wall thickness of the circulation hole at the fracture part is smaller than the hole wall thickness of the circulation hole at the drainage part; during surgical operation, the degradable inner drainage part is placed in the pancreatic duct, the fracture part crosses the anastomotic stoma by 7-8 cm and crosses the biliary-intestinal anastomotic stoma, and the leading-out part walks in the enteric cavity to a proper position, penetrates out of the intestinal wall and is led out of the body through the abdominal wall. Cutting the puncture part to expose the outlet of the circulation hole, and discharging the body fluid through the circulation hole; after a certain period of time after the operation, the fracture part is automatically fractured under the action of pancreatic juice, the leading-out part is pulled out, the degradable drainage part continues to be degraded in the body and maintains the drainage function, and finally the drainage part is absorbed by the body or discharged out of the body without being taken out through the operation.

A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a third filtrate.

The invention relates to absorbable adhesive styptic powder and a preparation method thereof, and the absorbable adhesive styptic powder is characterized in that the absorbable adhesive styptic powder is formed by cross-linking aldehyde polysaccharide and a polyamino compound through Schiff base reaction, the raw materials are selected from at least one of glucan, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan and carboxymethyl starch; the polyamino compound is selected from at least one of polylysine, polypeptide, bovine serum albumin and polyamine; the styptic powder is porous particles with the particle size of 10-1000 meshes, is cured into gel within 10 seconds after being in contact with body fluid, and is completely degraded within 15-60 days. According to the scheme, the styptic powder has the advantages of rapid wet adhesion, controllable degradation and excellent processability, and is an urgent clinical demand.

The invention discloses bi-crosslinking self-reinforced hydrogel based on endogenous glucose in-situ initiation as well as a preparation method and application of the bi-crosslinking self-reinforced hydrogel, and relates to the technical field of biomedical materials. The double-crosslinking self-enhanced hydrogel is prepared from the following components in concentration: 1 to 3 weight percent of hyaluronic acid-tyramine, 0.8 to 1.2 weight percent of sodium alginate, 1 to 100 mmol / L of calcium carbonate, 0.0001 to 10 U / mL of horse radish peroxidase, 20 to 40 U / mL of glucose oxidase and the balance of ultrapure water. The invention also discloses an application of the double-crosslinking self-reinforced hydrogel in preparation of a filling and repairing product for soft tissue defects. The hydrogel disclosed by the invention can be filled in a tissue defect part in an injection manner, glucose in body fluid is utilized to initiate crosslinking in situ to form the hydrogel with excellent mechanical properties and long-term stability, and meanwhile, the hydrogel is good in biocompatibility and relatively high in application value.

An example drainage port assembly includes a collar and a connector, The connector includes an engagement portion that is attached to or integrally formed with the collar and the conduit attachment portion that is distinct from the engagement portion. The engagement portion is configured to allow the conduit attachment portion to move relative to the collar. The collar and the connector define a collar passageway extending through the collar and a connector passageway extending through the connector, respectively. In some embodiments, the movement of the conduit attachment portion relative to the collar switches the drainage port assembly between a first state and a second state, wherein the drainage port assembly permits flow of bodily fluids therethrough when in the first state (e.g., through the collar passageway and the connector passageway) and restricts the flow of the bodily fluids therethrough w hen in the second state.

The present invention relates primarily to a reusable sanitary or incontinence article having a multilayer structure comprising an inner layer including a gusset area nearest to a wearer's skin for taking up body fluid from the wearer and / or transporting the body fluid away from the wearer; an outer layer including a sealing portion for providing a barrier for the body fluid and side edge portions; an absorbent core between the inner layer and the outer layer; and a fluid tight joint connecting the inner layer, the outer layer and optionally the absorbent core to each other along at least a part of a perimeter of the gusset area; wherein the sealing portion is composed of a textile coated with an adhering coating material that forms a contiguous, impervious coating extending at least over the gusset area into the side edge portions, and wherein the side edge portions extend from opposite sides outside the gusset area, are folded over side edges of and connected to the inner layer forming a fluid tight joint between the inner layer and the outer layer along side edges of the gusset area.

Various implementations include a breast tissue expander device. The device includes one or more tabs extending outwardly from a body of the device for coupling the device to the chest wall of a patient. The device further includes an aspiration port in fluid communication with a drain tube for draining body fluid, along with retention members for securing the drain tube to the body. The device may also include one or more flow barriers configured to prevent the inadvertent leakage of expansion fluid or body fluid from the device.

The invention relates to the crossing field of computer technology and edge calculation, and discloses a blood purification equipment real-time control method based on edge calculation. According to the method, multi-modal real-time physiological parameters, historical dialysis data and a current treatment target are fused through a local edge calculation unit, an individualized body fluid dynamic response prediction model is constructed, and an ultrafiltration rate instruction is optimized and generated within a millisecond level; the system comprises a multi-mode sensor array, a historical data storage module, a task planning interface, an edge computing unit and an ultrafiltration pump controller. According to the application, the hemodynamic state is accurately maintained, the risk of hypotension is remarkably reduced, and the treatment safety and individualization level are improved.

A device includes a pre-sample reservoir, an actuator mechanism, and a diverter. The pre-sample reservoir can be fluidically coupled to a delivery member to receive and isolate a predetermined volume of bodily-fluid withdrawn from a patient. The actuator mechanism is operably coupled to the pre-sample reservoir such that, when actuated, a negative pressure is formed in the pre-sample reservoir that urges the bodily-fluid to flow into the pre-sample reservoir. The diverter can selectively control fluid flow between the delivery member and the pre-sample reservoir. The diverter includes a flow control mechanism that defines a first fluid flow path and a second fluid flow path. The diverter is movable between a first configuration in which the bodily-fluid flows through the first fluid flow path to the pre-sample reservoir, and a second configuration in which the bodily-fluid flows through the second fluid flow path to a sample reservoir coupled to the diverter.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

The invention provides a traditional Chinese medicine-symptom association prediction method fusing traditional Chinese medicine theories and causal reasoning. The method comprises the following steps: firstly, extracting multi-dimensional characteristics of'taste, nature, channel tropism, rising and falling 'and the like of traditional Chinese medicines and multi-dimensional characteristics of'exogenous pathogenesis, endogenous pathogenesis, qi, blood, body fluid, viscera' and the like of symptoms from a traditional Chinese medicine knowledge base, constructing a quantitative system, then constructing a hierarchical traditional Chinese medicine causal diagram, and determining a bidirectional or unidirectional causal connection relationship among nodes; designing an edge relationship construction rule, and introducing a causal weight in message transmission; constructing a dual-channel heterogeneous graph neural network architecture, and updating node embedding through three rounds of iteration; and finally, through a combined loss function optimization model, outputting a scoring matrix with a confidence coefficient threshold value by a double-branch prediction head so as to accurately predict. The method excavates deep correlation between traditional Chinese medicines and symptoms, and provides a prediction tool for modernization of traditional Chinese medicines.

The invention discloses a composition with a sleep improving function as well as a preparation method and application thereof, and the composition is prepared from the following raw materials in parts by weight: 50-100 parts of acanthopanax root, 30-50 parts of lotus seed, 50-100 parts of spina date seed, 30 parts of lily, 30 parts of longan, 30-50 parts of poria cocos, 30 parts of radix ophiopogonis, 10-30 parts of rehmannia, 10-30 parts of gastrodia elata, 2 parts of glutamic acid, 0.1 part of vitamin B, 0.1 part of vitamin B6 and 0.1 part of gamma-aminobutyric acid. The traditional single target spot limitation is broken through, a synergistic effect system of tonifying the spleen and soothing the nerves-neurotransmitter regulation and control-intestinal brain axis regulation is formed, a buffer solution of pH simulation biological fluid is adopted as a non-organic extraction medium in the process, the ultrasonic cavitation effect and the plasma activation effect are combined, the temperature is controlled in the whole process, and the preparation method is simple and easy to implement. The problems of vortex, uneven extraction, dead volume, solvent residue, active ingredient damage and the like in traditional extraction are fundamentally solved, the composition capable of effectively improving the sleep quality is obtained, and animal model and crowd experiments prove that the composition can effectively improve the sleep quality and achieve a good sleep aiding effect.

The invention provides a primer probe set for digital PCR detection of non-small cell lung cancer EGFR mutation and application thereof, and relates to the technical field of digital PCR detection, the primer probe set comprises a primer pair and a probe for specific detection of EGFR gene exon 19 deletion mutation (19del) and exon 21 L858R point mutation, and the 19del mutation probe comprises a plurality of sequences to cover common subtypes. The primer probe group can be combined with a microfluidic digital PCR platform for use, a sample is divided into tens of thousands of microdroplets for amplification, and FAM, HEX, ROX and CY5 fluorescence channel signals are detected to realize absolute quantification. The system provided by the invention has high sensitivity and excellent linearity and precision, is particularly suitable for detecting extremely-low-frequency EGFR mutation in body fluid such as plasma, and has important application value in individualized diagnosis and treatment, curative effect monitoring and drug resistance evaluation of non-small cell lung cancer.

The invention provides a nitric oxide fluorescent probe with aggregation-induced emission characteristics and a preparation method and application thereof. The structural formula of the nitric oxide fluorescent probe is shown in the specification. The nitric oxide fluorescent probe provided by the invention is high in detection sensitivity, high in response speed, excellent in NO selectivity and AIE characteristic, wide in application range, not only suitable for liquid-phase and gas-phase NO detection, but also capable of realizing high-efficiency real-time detection of NO in body fluid, cells and living body samples, and wide in application prospect. The method can be used for diagnosis of diseases such as inflammation (rheumatoid arthritis), tumor microenvironment and the like, high-throughput drug screening and environment monitoring.

This body fluid amount evaluation device comprises a pulse pressure acquisition unit, a first calculation unit, a second calculation unit, and an evaluation unit. The pulse pressure acquisition unit acquires a first pulse pressure of a dialysis patient before returning blood in a dialyzer and a blood circuit, and a second pulse pressure of the dialysis patient at completion of returning the blood. The pulse pressure acquisition unit acquires the first pulse pressure and the second pulse pressure in a plurality of consecutive dialyses of the dialysis patient. The first calculation unit calculates the increase rate of the pulse pressure from the first pulse pressure and the second pulse pressure. The first calculation unit calculates the increase rate of the pulse pressure for each of the plurality of dialyses from the first pulse pressure and the second pulse pressure in each of the plurality of dialyses. The second calculation unit calculates an average value and / or an index that indicates variation of the increase rates of the pulse pressure in the plurality of dialyses. The evaluation unit evaluates the body fluid amount of the dialysis patient on the basis of the average value and / or the index that indicates variation which has been calculated by the second calculation unit.

The invention discloses a multi-nucleic acid probe rapid modification and multi-target detection device based on electric field regulation and control. An instrument main body in the device is integrated with an automatic liquid path system and a micro electrochemical workstation module, and is used for realizing programmable reagent and sample conveying and multi-channel electrochemical measurement. The detachable sensing chip is formed by bonding a microelectrode array chip and a micro-fluidic chip, and is switched through a PCB (Printed Circuit Board) to realize plug and play. According to the present invention, the positive suction-negative discharge strategy of the electric field is utilized, the preferred positive potential is applied to the target electrode to efficiently attract the probe, and the preferred negative potential is applied to the non-target electrode to inhibit the non-specific adsorption so as to achieve the spatial selective rapid fixation and the accurate density regulation and control of the multi-nucleic acid probe in the extremely short time; the device can be used for quantitatively detecting various body fluid disease markers in a plurality of urine samples at the same time in single operation, and an efficient, accurate and portable multi-marker comprehensive analysis solution is provided for early screening and instant diagnosis of tumors.

To provide a body fluid-based biological detection device and method.SOLUTION: A device includes, from bottom to top, a water-filtering layer, a molecularly imprinted polymer layer, and a flexible substrate layer. A biochemical sensor is integrated on the flexible substrate layer. In one state, the water-filtering layer filters water from the body fluid. The molecularly imprinted polymer layer recognizes and binds to biomarkers within the filtered body fluid. The binding of the biomarkers to the molecularly imprinted polymer layer changes the current of the biochemical sensor, thereby converting the biological signal in the body fluid into a physical signal. The present invention provides a body fluid-based biological detection device and method with high sensitivity and stable detection results.SELECTED DRAWING: Figure 6

The application provides an ultrasonic knife temperature monitoring regulation method, computer equipment and a storage medium, and relates to the technical field of medical instruments; the ultrasonic knife temperature monitoring regulation method comprises the following steps: obtaining relevant variables of the temperature of an ultrasonic knife, wherein the relevant variables comprise the contact condition of the head of the ultrasonic knife and body fluid; obtaining target detection boxes corresponding to the body fluid, the ultrasonic knife and the head in a real-time detection image according to a real-time detection image of the ultrasonic knife; predicting the temperature of the ultrasonic knife according to the relevant variables and the target detection boxes corresponding to the body fluid, the ultrasonic knife and the head, and obtaining the temperature change of the ultrasonic knife; and controlling the temperature of the ultrasonic knife through a preset operation according to the temperature change of the ultrasonic knife. The application can more accurately monitor and control the temperature of the ultrasonic knife, improve the controllability and accuracy of the head temperature in the operation process, and improve the temperature monitoring and regulation effect.

The invention discloses a collagen injection for tendon repair as well as a preparation method and application thereof, and belongs to the technical field of collagen preparation. The preparation method disclosed by the invention comprises the following steps: by taking a collagen dry product as a raw material, sequentially dissolving, carrying out secondary filtration, separating, preparing fibrotic collagen slurry A, preparing gelatinized collagen slurry B, preparing the solution, homogenizing and filling to prepare the collagen injection capable of being used for tendon repair. The collagen injection provided by the invention shows multiphase transformation during refrigeration and contact with body fluid with body temperature, and does not have the phenomenon of fiber layering in the long-term storage process. The collagen disclosed by the invention is an injection type gel preparation, can be flexibly injected and applied according to the depth and the area of a wound, is beneficial to promoting tissue regeneration and functional repair, and is particularly suitable for tendon injury and other scenes needing collagen to guide cell repair.

The invention relates to the technical field of prenatal diagnosis, in particular to a biomarker for early prediction of preeclampsia based on body fluid free DNA and application of the biomarker, and particularly relates to a biomarker for prediction or diagnosis of pregnancy diseases, especially preeclampsia, identified through a machine learning model based on a sample set. The biomarker can be eclampsia specific motif and related motif variation trend, so that early prediction of preeclampsia with low cost, high efficiency and high accuracy is realized.

A medical sampling device for use with an endoscope or catheter for flushing a body cavity and / or sampling a body fluid and / or body tissue, the endoscope or catheter having a suction channel and a suction connector in fluid communication with the suction channel, the sampling device comprising a suction inlet for connection to the suction connector, a suction outlet for connection to a vacuum source, a sampling outlet for connection to a sample container, a sampling inlet for connection to the sample container, and a valve having a valve member and a valve housing, wherein the valve member has a first chamber and a second chamber and is rotatable relative to the valve housing between a first position in which the first chamber establishes fluid communication between the suction inlet and the sampling inlet, a second position in which the second chamber establishes fluid communication between the sampling outlet and the suction outlet, and a third position in which one of the first chamber and the second chamber establishes fluid communication between the suction inlet and the suction outlet.