734 results about "Body fluid" patented technology

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

The invention provides an intermittent detection method and device for body fluid parameters and a related system.The method is applied to a body fluid parameter detection system, the system comprises an infusion tube, a detection module, an extraction and injection device, a liquid path switch and a flushing device.The method comprises the steps that the liquid path switch is controlled to execute a closing action, and the liquid path switch is controlled to close the infusion tube; controlling the extraction and injection device to extract a preset first volume of target body fluid from a preformed hole of a target user into the infusion tube, controlling the detection module to detect parameters of the target body fluid when the target body fluid in the infusion tube is detected to pass through the detection module, obtaining the parameters of the target body fluid, controlling the liquid path switch to execute an opening action, and controlling the liquid path switch to execute a closing action; and controlling the flushing device to inject a preset second volume of functional liquid into the infusion tube, and controlling the extraction and injection device to enable the target body fluid to flow back to the target user when the functional liquid in the infusion tube is detected to pass through the detection module. When blood gas parameter detection is carried out, blood waste and detection cost are reduced.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.

The invention discloses a self-breaking outer drainage tube, and relates to the technical field of medical instruments, the self-breaking outer drainage tube comprises a tube body, and the tube body comprises a drainage part, a breaking part, a leading-out part and a puncture part; the drainage part and the fracture part are both made of degradable materials; the hole wall thickness of the circulation hole at the fracture part is smaller than the hole wall thickness of the circulation hole at the drainage part; during surgical operation, the degradable inner drainage part is placed in the pancreatic duct, the fracture part crosses the anastomotic stoma by 7-8 cm and crosses the biliary-intestinal anastomotic stoma, and the leading-out part walks in the enteric cavity to a proper position, penetrates out of the intestinal wall and is led out of the body through the abdominal wall. Cutting the puncture part to expose the outlet of the circulation hole, and discharging the body fluid through the circulation hole; after a certain period of time after the operation, the fracture part is automatically fractured under the action of pancreatic juice, the leading-out part is pulled out, the degradable drainage part continues to be degraded in the body and maintains the drainage function, and finally the drainage part is absorbed by the body or discharged out of the body without being taken out through the operation.

The invention discloses bi-crosslinking self-reinforced hydrogel based on endogenous glucose in-situ initiation as well as a preparation method and application of the bi-crosslinking self-reinforced hydrogel, and relates to the technical field of biomedical materials. The double-crosslinking self-enhanced hydrogel is prepared from the following components in concentration: 1 to 3 weight percent of hyaluronic acid-tyramine, 0.8 to 1.2 weight percent of sodium alginate, 1 to 100 mmol / L of calcium carbonate, 0.0001 to 10 U / mL of horse radish peroxidase, 20 to 40 U / mL of glucose oxidase and the balance of ultrapure water. The invention also discloses an application of the double-crosslinking self-reinforced hydrogel in preparation of a filling and repairing product for soft tissue defects. The hydrogel disclosed by the invention can be filled in a tissue defect part in an injection manner, glucose in body fluid is utilized to initiate crosslinking in situ to form the hydrogel with excellent mechanical properties and long-term stability, and meanwhile, the hydrogel is good in biocompatibility and relatively high in application value.

Various implementations include a breast tissue expander device. The device includes one or more tabs extending outwardly from a body of the device for coupling the device to the chest wall of a patient. The device further includes an aspiration port in fluid communication with a drain tube for draining body fluid, along with retention members for securing the drain tube to the body. The device may also include one or more flow barriers configured to prevent the inadvertent leakage of expansion fluid or body fluid from the device.

The invention relates to the crossing field of computer technology and edge calculation, and discloses a blood purification equipment real-time control method based on edge calculation. According to the method, multi-modal real-time physiological parameters, historical dialysis data and a current treatment target are fused through a local edge calculation unit, an individualized body fluid dynamic response prediction model is constructed, and an ultrafiltration rate instruction is optimized and generated within a millisecond level; the system comprises a multi-mode sensor array, a historical data storage module, a task planning interface, an edge computing unit and an ultrafiltration pump controller. According to the application, the hemodynamic state is accurately maintained, the risk of hypotension is remarkably reduced, and the treatment safety and individualization level are improved.

A device includes a pre-sample reservoir, an actuator mechanism, and a diverter. The pre-sample reservoir can be fluidically coupled to a delivery member to receive and isolate a predetermined volume of bodily-fluid withdrawn from a patient. The actuator mechanism is operably coupled to the pre-sample reservoir such that, when actuated, a negative pressure is formed in the pre-sample reservoir that urges the bodily-fluid to flow into the pre-sample reservoir. The diverter can selectively control fluid flow between the delivery member and the pre-sample reservoir. The diverter includes a flow control mechanism that defines a first fluid flow path and a second fluid flow path. The diverter is movable between a first configuration in which the bodily-fluid flows through the first fluid flow path to the pre-sample reservoir, and a second configuration in which the bodily-fluid flows through the second fluid flow path to a sample reservoir coupled to the diverter.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

The invention provides a traditional Chinese medicine-symptom association prediction method fusing traditional Chinese medicine theories and causal reasoning. The method comprises the following steps: firstly, extracting multi-dimensional characteristics of'taste, nature, channel tropism, rising and falling 'and the like of traditional Chinese medicines and multi-dimensional characteristics of'exogenous pathogenesis, endogenous pathogenesis, qi, blood, body fluid, viscera' and the like of symptoms from a traditional Chinese medicine knowledge base, constructing a quantitative system, then constructing a hierarchical traditional Chinese medicine causal diagram, and determining a bidirectional or unidirectional causal connection relationship among nodes; designing an edge relationship construction rule, and introducing a causal weight in message transmission; constructing a dual-channel heterogeneous graph neural network architecture, and updating node embedding through three rounds of iteration; and finally, through a combined loss function optimization model, outputting a scoring matrix with a confidence coefficient threshold value by a double-branch prediction head so as to accurately predict. The method excavates deep correlation between traditional Chinese medicines and symptoms, and provides a prediction tool for modernization of traditional Chinese medicines.

The invention discloses a composition with a sleep improving function as well as a preparation method and application thereof, and the composition is prepared from the following raw materials in parts by weight: 50-100 parts of acanthopanax root, 30-50 parts of lotus seed, 50-100 parts of spina date seed, 30 parts of lily, 30 parts of longan, 30-50 parts of poria cocos, 30 parts of radix ophiopogonis, 10-30 parts of rehmannia, 10-30 parts of gastrodia elata, 2 parts of glutamic acid, 0.1 part of vitamin B, 0.1 part of vitamin B6 and 0.1 part of gamma-aminobutyric acid. The traditional single target spot limitation is broken through, a synergistic effect system of tonifying the spleen and soothing the nerves-neurotransmitter regulation and control-intestinal brain axis regulation is formed, a buffer solution of pH simulation biological fluid is adopted as a non-organic extraction medium in the process, the ultrasonic cavitation effect and the plasma activation effect are combined, the temperature is controlled in the whole process, and the preparation method is simple and easy to implement. The problems of vortex, uneven extraction, dead volume, solvent residue, active ingredient damage and the like in traditional extraction are fundamentally solved, the composition capable of effectively improving the sleep quality is obtained, and animal model and crowd experiments prove that the composition can effectively improve the sleep quality and achieve a good sleep aiding effect.

The invention provides a primer probe set for digital PCR detection of non-small cell lung cancer EGFR mutation and application thereof, and relates to the technical field of digital PCR detection, the primer probe set comprises a primer pair and a probe for specific detection of EGFR gene exon 19 deletion mutation (19del) and exon 21 L858R point mutation, and the 19del mutation probe comprises a plurality of sequences to cover common subtypes. The primer probe group can be combined with a microfluidic digital PCR platform for use, a sample is divided into tens of thousands of microdroplets for amplification, and FAM, HEX, ROX and CY5 fluorescence channel signals are detected to realize absolute quantification. The system provided by the invention has high sensitivity and excellent linearity and precision, is particularly suitable for detecting extremely-low-frequency EGFR mutation in body fluid such as plasma, and has important application value in individualized diagnosis and treatment, curative effect monitoring and drug resistance evaluation of non-small cell lung cancer.

The invention provides a nitric oxide fluorescent probe with aggregation-induced emission characteristics and a preparation method and application thereof. The structural formula of the nitric oxide fluorescent probe is shown in the specification. The nitric oxide fluorescent probe provided by the invention is high in detection sensitivity, high in response speed, excellent in NO selectivity and AIE characteristic, wide in application range, not only suitable for liquid-phase and gas-phase NO detection, but also capable of realizing high-efficiency real-time detection of NO in body fluid, cells and living body samples, and wide in application prospect. The method can be used for diagnosis of diseases such as inflammation (rheumatoid arthritis), tumor microenvironment and the like, high-throughput drug screening and environment monitoring.

This body fluid amount evaluation device comprises a pulse pressure acquisition unit, a first calculation unit, a second calculation unit, and an evaluation unit. The pulse pressure acquisition unit acquires a first pulse pressure of a dialysis patient before returning blood in a dialyzer and a blood circuit, and a second pulse pressure of the dialysis patient at completion of returning the blood. The pulse pressure acquisition unit acquires the first pulse pressure and the second pulse pressure in a plurality of consecutive dialyses of the dialysis patient. The first calculation unit calculates the increase rate of the pulse pressure from the first pulse pressure and the second pulse pressure. The first calculation unit calculates the increase rate of the pulse pressure for each of the plurality of dialyses from the first pulse pressure and the second pulse pressure in each of the plurality of dialyses. The second calculation unit calculates an average value and / or an index that indicates variation of the increase rates of the pulse pressure in the plurality of dialyses. The evaluation unit evaluates the body fluid amount of the dialysis patient on the basis of the average value and / or the index that indicates variation which has been calculated by the second calculation unit.

The application provides an ultrasonic knife temperature monitoring regulation method, computer equipment and a storage medium, and relates to the technical field of medical instruments; the ultrasonic knife temperature monitoring regulation method comprises the following steps: obtaining relevant variables of the temperature of an ultrasonic knife, wherein the relevant variables comprise the contact condition of the head of the ultrasonic knife and body fluid; obtaining target detection boxes corresponding to the body fluid, the ultrasonic knife and the head in a real-time detection image according to a real-time detection image of the ultrasonic knife; predicting the temperature of the ultrasonic knife according to the relevant variables and the target detection boxes corresponding to the body fluid, the ultrasonic knife and the head, and obtaining the temperature change of the ultrasonic knife; and controlling the temperature of the ultrasonic knife through a preset operation according to the temperature change of the ultrasonic knife. The application can more accurately monitor and control the temperature of the ultrasonic knife, improve the controllability and accuracy of the head temperature in the operation process, and improve the temperature monitoring and regulation effect.

The invention discloses a collagen injection for tendon repair as well as a preparation method and application thereof, and belongs to the technical field of collagen preparation. The preparation method disclosed by the invention comprises the following steps: by taking a collagen dry product as a raw material, sequentially dissolving, carrying out secondary filtration, separating, preparing fibrotic collagen slurry A, preparing gelatinized collagen slurry B, preparing the solution, homogenizing and filling to prepare the collagen injection capable of being used for tendon repair. The collagen injection provided by the invention shows multiphase transformation during refrigeration and contact with body fluid with body temperature, and does not have the phenomenon of fiber layering in the long-term storage process. The collagen disclosed by the invention is an injection type gel preparation, can be flexibly injected and applied according to the depth and the area of a wound, is beneficial to promoting tissue regeneration and functional repair, and is particularly suitable for tendon injury and other scenes needing collagen to guide cell repair.

A medical sampling device for use with an endoscope or catheter for flushing a body cavity and / or sampling a body fluid and / or body tissue, the endoscope or catheter having a suction channel and a suction connector in fluid communication with the suction channel, the sampling device comprising a suction inlet for connection to the suction connector, a suction outlet for connection to a vacuum source, a sampling outlet for connection to a sample container, a sampling inlet for connection to the sample container, and a valve having a valve member and a valve housing, wherein the valve member has a first chamber and a second chamber and is rotatable relative to the valve housing between a first position in which the first chamber establishes fluid communication between the suction inlet and the sampling inlet, a second position in which the second chamber establishes fluid communication between the sampling outlet and the suction outlet, and a third position in which one of the first chamber and the second chamber establishes fluid communication between the suction inlet and the suction outlet.

The invention discloses a drug delivery device in a human body cavity, which comprises an inflatable balloon, at least one part of the outer wall of the balloon is provided with a protective shell, the balloon is provided with an inner cavity, and the protective shell can be dissolved by specific body fluid in the human body cavity; the triggering part is arranged in an inner cavity of the balloon, and the triggering part can react with body fluid to generate fluid to inflate the balloon when making contact with the body fluid, so that the inflated balloon is tightly attached to the wall of a body cavity; the propelling part is arranged in the inner cavity of the balloon and comprises a tissue penetrating component, and the triggering part can generate power to propel the tissue penetrating component; and the containing part is used for containing a medicine preparation, and the triggering part can push and press the liquid medicine preparation contained in the containing part into the pushing part after the balloon is inflated, and injects the liquid medicine preparation into the inner wall tissue of the human body cavity through the tissue penetrating component. By means of the device, macromolecular drugs or preparations can be injected into the inner wall of the human body cavity, such as the tissue of the intestinal wall.

Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Fluid collection assemblies including a sample port, systems including the same, and methods of using the same are disclosed herein. An example fluid collection assembly includes a fluid impermeable barrier including a first end region, a second end region opposite the first end region, and a sump that forms at least a portion of the first end region. The fluid impermeable barrier also defines at least one opening between the first end region and the second end region and a fluid reservoir that is defined by at least a portion of the sump. The fluid collection assembly also includes at least one wicking material disposed in the chamber and a sample port extending from the sump. The sample port is configured to be connected to a fluid collector. The sample port is in fluid communication with the fluid reservoir such that a sample of the bodily fluids received by the fluid collection assembly may be obtained.

The present disclosure relates to uricase variant polypeptides and their multimers, as well as uricase conjugates comprising (i) a first domain comprising one of the uricase variant polypeptides conjugated to (ii) a second domain comprising a random coil polypeptide domain. Methods of using the uricase variant polypeptides and uricase conjugates to treat gout, tumor lysis syndrome, and other diseases associated with elevated uric acid levels in body fluids, including blood, are provided. Methods of recombinantly producing the uricase variant polypeptides and uricase conjugates disclosed herein are also provided.

This invention discloses a rapid mass spectrometry method and kit for the simultaneous detection of multiple components in body fluids, belonging to the field of biological detection and identification technology. It can rapidly detect trace compounds such as drugs and biomarkers in complex biological samples. This kit mainly utilizes loaded functional materials to achieve extraction and enrichment of target analytes and is equipped with a quick connector for coupling with a detector to achieve rapid detection. Compared with traditional methods, the significant advantages of the method established by this kit are that it does not require complex sample pretreatment, allows for micro-quantitative sampling, requires small sample volumes, facilitates convenient storage of biological samples, is easy to operate, does not require specialized technical personnel, and enables rapid on-site detection when coupled with portable mass spectrometry. This kit has been successfully used for the detection of quinine, procainamide hydrochloride, atenolol, and nortriptyline in complex samples such as blood and serum, and has significant clinical and economic value.

This invention relates to a body fluid-based detection device for chronic diseases, which belongs to the field of medical devices. The device includes a body fluid detection fluid channel, a detection probe, a data processing module, and a data display module. The detection probe is disposed within the body fluid detection fluid channel, and the detection probe is connected to the data processing module, which is connected to the data display module. The body fluid detection fluid channels include: a body fluid ion detection channel, a body fluid pH detection channel, a body fluid hydrodynamic characteristic detection channel, a channel for detecting the content of soluble gases such as oxygen, a channel for detecting the physical characteristics of white blood cells and tumor cells, a channel for detecting the electrical characteristics of white blood cells and tumor cells, a channel for detecting the physical characteristics of red blood cells, a channel for detecting the electrical characteristics of red blood cells, a channel for detecting the electrical characteristics of separated body fluids, and a channel for detecting anticoagulation and fibrinolysis functions. This invention enables highly sensitive, non-invasive testing, providing a powerful tool for the early diagnosis of chronic diseases.

This invention provides a 3D-printed hollow microneedle array resin patch, its preparation and application, a continuous glucose monitoring device, and a method for dynamic monitoring of blood glucose concentration, belonging to the field of biomedical technology. The hollow microneedle array resin patch of this invention features a "well"-shaped support to ensure the porosity of the perforated microneedles; the design of a hollow conical side opening greatly improves the porosity and microneedle pore volume, effectively increasing the amount of body fluid collected and thus improving detection accuracy. Based on 3D printing technology, the 3D-printed hollow microneedle array resin patch of this invention allows for the determination of basic parameters according to the diameter and height of existing needle sensors, as well as the depth of the stratum corneum and pain nerves, thereby achieving customization of the hollow microneedle combined with the needle sensor structure. It is suitable for needle sensors of different sizes, providing feasibility for microneedles to penetrate subcutaneously for biomarker detection.

The invention provides a multi-dimensional evaluation method and system for the thirst degree of a user, and the method comprises the steps: obtaining the body fluid detection data of the user, the blood detection data of the user, and the appearance detection image of the user, and extracting each water shortage characterization feature of the user based on the appearance detection image of the user; identifying the actual water shortage degree of the user through a water shortage degree evaluation model on the basis of each water shortage characterization feature of the user, the thirst degree independently narrated by the user, the body fluid detection data of the user and the blood detection data of the user; and recognizing the thirst degree independently narrated by the user, and recognizing the actual thirst degree of the user in combination with the actual water shortage degree of the user. By adopting the scheme, the evaluation accuracy of the actual thirst degree of the user who is limited to eat water can be improved, and a decision basis is provided for accurately identifying the water shortage condition of the user, preventing dehydration complications and optimizing liquid management.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

Provided is a water-absorbing sanitary shorts capable of improving the diffusivity of bodily fluids and suppressing backflow of the fluids. The water-absorbent sanitary shorts (1) are reusable shorts, and have a surface layer (10), an absorbent layer (20) disposed on the non-skin surface side (T2) of the surface layer, and a water-repellent layer (30) disposed on the non-skin surface side of the absorbent layer. The surface layer and the absorbent layer contain non-water-absorbent fibers as the main body. The hydrophobicity of the skin surface of the surface layer is higher than the hydrophobicity of the non-skin surface of the surface layer. The absorbent layer has an introduction region (25) in which the density increases from the skin surface side toward the non-skin surface side. The introduction region has a diffusion portion (27) containing fibers oriented in a planar direction.