171 results about "Biological fluids" patented technology

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

The application relates to the technical field of free radical detection, in particular to a high-sensitivity in-situ capture and detection method of organic free radicals based on a DIPPMPO probe and application, and the method comprises the following steps: adding a chemical probe DIPPMPO into a reaction system containing potential organic free radical precursors, so that the DIPPMPO and organic free radicals generated in a reaction process occur adduct reaction to form a DIPPMPO-free radical adduct which can be detected under liquid chromatography-mass spectrometry conditions; performing high performance liquid chromatography-quadrupole-time of flight mass spectrometry analysis on a mixed solution after the adduct reaction is completed, so that first mass spectrometry data and secondary mass spectrometry fragment information of the DIPPMPO-free radical adduct are obtained; and automatically processing the secondary mass spectrometry data, screening out parent ions with continuous neutral loss as potential DIPPMPO-free radical adduct candidate signals. The application does not need derivatization, is simple to operate, is broad-spectrum and high-efficiency, and can be applied to environmental water samples, biological fluids, chemical reaction liquids or drug metabolism systems.

A method for activating a physiological signal sensing device through a handheld device to measure a physiological signal of an analyte in biological fluids is provided. The physiological signal sensing device includes a transmitter including a power unit, a switch unit, a magnetic field sensing unit and a processing unit. The method includes: establishing an inductive magnetic field between the handheld device and the transmitter, causing the magnetic field sensing unit to generate an inductive signal; in a first operating cycle, activating the switch unit by the inductive signal, causing the power unit to connect to the processing unit to activate the processing unit; providing an activation signal by the processing unit to turn on the switch unit; causing the switch unit to enter a self-maintaining state; and in a second operating cycle, connecting the power unit to the processing unit through the switch unit in the self-maintaining state.

To provide biological fluid purification using a biocompatible membrane.SOLUTION: An apparatus for integrated adaptive biological blood purification includes a function unit. The function unit is provided with: a membrane including a pipe surface and a filtration surface; a blood vessel channel system which is adhered to the blood vessel surface of the membrane and includes a first lumen space in fluid communication with the blood vessel surface of the membrane, a first end configured to be in fluid communication with a fluid supply part and to contact the same, and a second end configured to be in fluid communication with a filtration fluid outlet and to contact the same; and a filtration channel system which is adhered to the filtration surface of the membrane and includes a second lumen space in fluid communication with the filtration surface of the membrane and a third end configured to be in fluid communication with a filtrate outlet and to contact the same.SELECTED DRAWING: Figure 11

Soluble gp120 (sgp120) is associated to HIV-1-induced immune dysfunction, such as chronic immune activation. However, the detection of sgp120 in biological fluids such as plasma, serum, cervicovaginal fluids, and cerebrospinal fluids is challenging. The present application relates to novel methods and kits for the detection of sgp120 in biological fluids. These methods and kits are based on the use of specific combinations of sgp120-binding molecules recognizing particular domains of sgp120, notably the N-terminal 8-stranded β-sandwich structure, the constant region 1 and 2 (C1-C2) portion, the bridging sheet of the Co-Receptor Binding Site (CoRBS), and / or the CD4-binding domain.

The present disclosure provides materials and methods related to the purification of a biologic from a biological fluid. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.

Provided is a biological fluidic system that provides a high degree of sterilization by performing the biological processing in a closed system in which the fluid is contained in chambers that are isolated from the environment in a manner that does not permit ingress of contaminants.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A composition and method for preserving a wide variety of analyte classes, including but not limited to small molecules, peptides, proteins, nucleic acids, carbohydrates, and lipids, ensuring stability and reproducibility of their compartmental concentration over the time course of storage at room temperature, thus enabling cost-efficient tests and logistics for the analysis of these samples.

A biological fluid processing device includes pump and valve systems, a controller, and an optical detection assembly. During a biological fluid processing procedure, the controller controls the operation of the pump and valve systems to separate a cell-containing fluid from the blood of a blood source and controls the optical detection assembly to emit light through the cell-containing fluid. The controller receives signals from the optical detection assembly that are indicative of the intensity of light that has passed through the cell-containing fluid. The controller receives or calculates an adjustment factor that is derived from historical data reflecting a cell collection procedure previously executed for the same blood source in which the same type of cell was collected. The controller determines an adjusted cell concentration of the cell-containing fluid based at least in part on the signals from the light detector and the adjustment factor.

Methods and kits of rapidly isolating molecules from a sample are provided. Methods of treating a subject in need thereof using the rapid isolation kits and / or methods described herein are also provided. In some embodiments, the molecules are selected from ribosomes, DNA, RNA, and protein. In some embodiments, the sample is selected from a tissue sample, a blood sample, a non-blood biological fluid sample, and a whole organism sample.

A system provides for an ability to automatically identify one or more chemical components of a sample, especially a biological fluid sample, based on analysis of spectral data by at least one artificial intelligence module. The artificial intelligence module is able to be trained on a plurality of spectral data samples having known concentrations of individual chemicals and elements. The system is preferably used for spectral techniques such as UV / vis and near-infrared (NIR) spectrophotometry, but is also able to be used for other forms of spectroscopic techniques, including mass spectrometry, infrared (IR) spectrometry, X-ray spectroscopy, Raman spectrometry, or nuclear magnetic resonance (NMR) spectrometry.

A method for cleaning a blood filter comprises: (i) pumping a physiologically safe fluid in both directions through the inner and / or outer portions of a plurality of hollow fiber membranes of the blood filter to remove or separate blood residues, such as blood clots, proteins, and / or biological fluid; (ii) injecting air into the physiologically safe fluid to form an air / fluid mixture; (iii) pumping the air / fluid mixture through the inner and / or outer portions of the plurality of hollow fiber membranes of the blood filter to further remove or separate blood residues from it; and (iv) disposing of the physiologically safe air / fluid mixture with the removed or separated blood residues to the purge.

The invention relates to a sachet that prevents the technical problems caused by the presence of spaces between the polymers swelling spherically, which polymers reduce the volume of the fluid by removing water and other small molecules from the body fluid by means of elastic hydrophilic polymer meshed structures.

The present invention describes a comprehensive system and method for the simultaneous early detection of multiple cancers in a single analysis. The system involves a Liquid Chromatography-Mass Spectrometry (LC-MS) device coupled with processors and AI / ML algorithms. The LC-MS device analyses metabolite ions from dried extracts of biological fluid samples, aligning and normalizing the data while minimizing errors. Quality control processes, including a neural network model and critical ion monitoring, ensure accurate detection. The system employs AI / ML processes to create two models: the Cancer Detection AI (CDAI) Model for identifying cancerous samples, and the Tissue of Origin Identification (TOOAI) Model for distinguishing specific cancer types. The models are applied to test samples, providing scores based on tissue of origin probabilities. The invention aims to revolutionize early cancer detection through advanced analytical and machine learning techniques.

Methods of differentiating and quantifying modifications in the tau protein in bio-fluids to detect, classify, and treat a plurality of tauopathies are disclosed. The disclosed methods include liquid chromatographic mass spectrometric analyses on isolated tau protein fragments to identify and quantify deamidated or isomerized asparagines or aspartic acids indicative of a neuropathology associated with a tauopathy.

1. The name of the design product: electrode of biosensor assembly (two). 2. The use of the design product: for forming biosensor assembly, biosensor assembly containing electrode and other components of biosensor, such as fluid channel, jointly forming biosensor for detecting biological fluid sample. 3. The design points of the design product: in the front view. 4. The picture or photo that can best show the design points: front view. 5. Other circumstances that need to be explained: the non-dotted part is the local part that needs to be protected, and the line is displayed in accordance with the projection rules of each view.

The utility model discloses a biological fluid continuous disinfection system in the technical field of disinfection systems. The biological fluid continuous disinfection system comprises biological fluid, a feeding system, a preheating system, a heating system, a maintaining system and a cooling system, the feeding system comprises a storage tank, a liquid level sensor, cleaning liquid, first industrial steam, a filter, a conveying pump and a flow meter, the preheating system comprises at least one preheater, biological fluid conveyed by the conveying pump flows through the preheater, the biological fluid flowing through the maintaining system flows through the preheater through a pipeline, and the pipeline is communicated with the storage tank. The biological fluid flowing through the maintaining system preheats the biological fluid conveyed by the conveying pump; the heating system comprises a heater, second industrial steam and a proportioning valve, the maintaining system comprises a maintaining pipe, a maintaining tank and a temperature sensor, and the cooling system comprises a cooler, a cooling water inlet pipe, a cooling water outlet pipe and a discharging tank.

The present invention describes a comprehensive system and method for the simultaneous early detection of multiple cancers in a single analysis. The system involves a liquid chromatography-mass spectrometry (LC-MS) instrument coupled with a processor and AI / ML algorithms. The LC-MS instrument analyzes metabolite ions from dried extracts of biological fluid samples and aligns and normalizes the data while minimizing errors. Quality control processes, including neural network models and critical ion monitoring, ensure accurate detection. The system employs an AI / ML process to create two models: a Cancer Detection AI (CDAI) model for identifying cancer samples and a Tissue of Origin Identification (TOOAI) model for distinguishing specific cancer types. These models are applied to test samples and provide a score based on tissue of origin probability. The present invention aims to revolutionize early cancer detection through advanced analytical and machine learning techniques.

The present disclosure provides devices, systems, and methods for the point-of-care analysis of target analytes in biological fluids by binding assays. The present disclosure includes a cartridge for collecting target analytes contained in a fluid sample and performing an assay. The cartridge includes an assay stack having a first separation layer, a second separation layer, and a detection membrane. The cartridge also includes a plurality of first complexes containing capture molecules and magnetic beads and a plurality of second complexes containing detection molecules and detection labels. Further, the detection membrane contains a substrate that interacts with the detection labels to initiate a quantifiable reaction in the presence of the target analytes. The quantifiable reaction corresponds to the amount of detection antibodies present in the detection membrane, and the amount of detection antibodies present corresponds to the amount of target analytes present.

A magnetic selector includes a housing configured to receive a container and having a floor upon which the container is disposed. The selector also includes a magnet carrier disposed on an opposite side of the floor from the container. The magnet carrier has at least one magnet disposed thereon and being moveable relative to the floor between a first state wherein the magnet carrier is adjacent the floor and a second state wherein the magnet carrier is spaced from the floor. The selector may include a door. The magnetic selector is usable in a fluid processing system that includes a fluid processor connectable to a source container filled with a biological fluid. A container is disposed in the magnetic selector and connected to the processor along a fluid pathway. The processor is configured to separate the biological fluid from the source container into at least two streams of material.

The present disclosure relates generally to bioactive releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel bioactive releasing membranes, to devices and implantable devices including these membranes, methods for forming the bioactive releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.

An electrochemical biosensor chip for the simultaneous quantitative detection of a plurality of different target molecules in a biological fluid, wherein the biosensor chip comprises: a) a substrate with a microfluidic structure designed to guide the biological fluid, b) a plurality of electrochemically isolated detection modules arranged along the microfluidic structure, c) wherein each detection module is structurally assigned to a specific target molecule and differs from the other detection modules by at least one irreversible structural feature selected from: -Electrode geometry, -Electrode surface, -Surface chemistry, - or a combination thereof, d) wherein each detection module comprises a working electrode, a counter electrode and a reference electrode, e) wherein each detection module is linked to a fixed electrochemical redox system which defines a module-specific electrochemical operating window, f) wherein the electrochemical operating windows of the detection modules do not overlap, (g) and wherein the biosensor chip comprises at least one non-functionalized internal reference electrode configured for hardware-based signal normalization, independent of the chemical identity of the target molecules.

The invention discloses a novel nanogold sensing method for continuously detecting various heavy metals by fluorescence'on-off-on 'based on a gradual detection strategy. Gold nanoclusters (GSH-AuNCs) taking glutathione (GSH) as a reducing agent and a stabilizing agent respond to various heavy metals to cause fluorescence quenching, and a novel GSH-AuNCs visual sensing platform is designed according to the remarkable difference of fluorescence intensity before and after coordination / redox competition, so that four heavy metal ions of Fe (III), Cu (II), Hg (II) and Cr (VI) are successfully and rapidly detected step by step. The method is simple in operation steps, high in detection speed (Fe (III): 3 min, Cu (II): 30 s, Hg (II): 3 min and Cr (VI): 3 min), wide in quantitative range (0.1-200 [mu] M), high in sensitivity (LDDFe (III): 87 nM, LODCu (II): 36 nM, LODHg (II): 32 nM and LODCr (VI): 75 nM) and high in anti-interference capability, and is successfully applied to gradual detection of four heavy metals in actual water and biological fluid (urine and serum).

A sensor has a radiation emitter, a plurality of electrodes, a sensing material (transducer), and a recognition element (receptor, bioreceptor). The radiation element irradiates the sensing material, the plurality of electrodes are in electrical contact with the sensing material, and the recognition element is in contact, either directly or through an interface, with the sensing material. The sensing material receives radiation from the radiation source and interacts with the target material largely through the receptor. Further, the sensing material generates a measurable electrical signal upon interaction with a target molecule, when a potential is applied to the electrodes.