487 results about "Biological fluids" patented technology

A wearable device consists of a smart band and a display unit. The smart band comprises a microbial biosensor, a particulate matter sensor, an enviro sensor, a physiological sensor, a biofluid sensor, a biokinetics sensor, a lifestyle sensor, and a single board computer. The microbial biosensor detects, measures, and monitors microorganisms, and a sterilizer kills pathogens. The particulate matter sensor detects, measures, and monitors a set of suspended particles in the surrounding air. The enviro sensor monitors environmental conditions surrounding the user. The biofluid sensor detects, measures, and monitors biological fluid parameters of the user. The physiological sensor detects, measures, and monitors physiological parameters of the user. The biokinetics sensor detects, measures, and monitors physical activities of the user. The lifestyle sensor detects, measures, and monitors healthy lifestyle activities of the user. The wearable device allows for continuous monitoring of user health for accurate clinical outcomes and wellness programs.

An electrochemical sensor extracts information from biofluid systems by harnessing a nonlinear dynamic electrochemical model and stochastic voltage or current input. It uses a black-box approach that describes the fluid's state and predicts its evolution over time using a collection of model parameters, nonlinear dynamic measurement modes, and modeling techniques. For example, the sensor can use principal component analysis to reduce the set of (potentially hundreds) of model parameters to a handful of latent variables which evolve independently of each other. The sensor can use a set of these latent variables as a description of the state of the fluid. For a given sample fluid (e.g., milk containing contaminants), the sensor collects trajectories of the fluid state over time under varying conditions, permitting the training of a machine learning model to predict either fluid state trajectories or time until the fluid state crosses a given threshold (e.g., spoilage).

The disclosure provides an extracorporeal devices, systems and methods for removing a pathogen or a toxin from a biological fluid of a subject comprising contacting a biological fluid from the subject with a loosely packed bed of adsorption media, such as a fluidized bed, wherein the adsorption media comprises heparin, to remove the pathogen or the toxin to form a treated biological fluid; and infusing the treated fluid into the subject.

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

Disclosed herein is a device and method for measuring spatial mass distribution profiles to weigh the accumulated-aggregated mass of an analyte in a crowded bioorganic material background by employing a high frequency recognition pattern. The recognition pattern allows for the Fourier filtering of mass sensitive image data for background and noise subtraction. The device and method enables the screening of a biological fluid sample for an analyte associated with proteinopathy.

Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

The invention provides a light-excited lateral flow immunosensor reagent strip, a detection analysis method and application of the light-excited lateral flow immunosensor reagent strip. The reagent strip comprises an electrode substrate, a combination pad, a sample pad layer, a chromatography membrane and a water absorption pad, and the sample pad layer, the combination pad, the chromatography membrane and the water absorption pad of the reagent strip are connected end to end and are sequentially overlapped and pasted on the electrode substrate. The light-excited lateral flow immunosensor reagent strip is applied to quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid or urine.

Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.

The invention discloses a method for simply extracting and accurately determining and quantifying micro-nano plastic in biological fluid. The method comprises the following steps: heating and digesting the biological fluid by using a strong oxidant; after digestion, adding a moistening solution for ultrasonic treatment, collecting the treated solution, and detecting the particle size of particles in part of the mixed solution; and filtering the residual mixed solution to separate out the micro-plastics. Meanwhile, collecting a filtrate containing the nano plastic, and directly transferring the filtrate into a sample boat to be heated and concentrated until the filtrate is dry; and a thermal cracking / thermal desorption-gas chromatograph-mass spectrometer is used for detecting the types and contents of the medium-micro plastic and the nano plastic. According to the method, the micro-nano plastic in different biological fluids can be simply extracted, accurate qualitation and quantification can be realized, and the technical bottlenecks that the extraction of the micro-nano plastic in the biological fluids is tedious and the particle size of the micro-nano plastic particles and accurate qualitation and quantification cannot be considered at the same time at present are broken; and an available technical method is provided for comprehensively and deeply analyzing the in-vivo health risk of the micro-nano plastic.

Systems and methods for a wearable stress response assessment system may include an iontophoresis module, a multi-inlet microfluidic sweat sampling component, and a sensor patch configured to detect concentrations of electrolytes and metabolites present in a sweat sample and monitor physiological signs prevalent in a human patient. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and / or application of a stimulating agent. A microfluidic sweat sampling component may include adhesive and PDMS layers with carefully designed inlets and channels for efficient collection and sampling of biofluid. Enzymatic and ISE biosensors may quickly and accurately identify concentrations of key biomarkers present in a biofluid sample which may assess, in combination with monitored physiological signs, a human patient's stress response.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

The invention discloses a full-automatic intelligent physical and chemical detection work station, relates to the technical field of biological fluid purification and extraction, and solves the problems of poor procedure connection and low detection efficiency of physical and chemical detection of body fluid. The test tube rotating module comprises a rotatable rotating table, a plurality of clamping mechanisms respectively used for clamping test tubes with different diameters, a pushing and pressing mechanism matched with one of the clamping mechanisms, and a loosening mechanism for controlling the clamping mechanisms to loosen the test tubes; the reagent rotating module is located below the test tube rotating module, the reagent rotating module comprises a rotatable rotating disc, and a plurality of placing positions for placing reagent bottles are arranged in the circumferential direction of the rotating disc; and at least one lifting mechanism. According to the invention, all procedures of purification operation of biological fluid can be seamlessly connected, the types of reagents can be automatically selected according to different types of the biological fluid, and the efficiency of physical and chemical detection is greatly improved.

The invention relates to a real-time enrichment and detection method for extracellular vesicles. Belongs to the technical field of biological detection. The preparation method comprises the following steps: firstly, preparing a silicon dioxide colloidal crystal (SCC) thin film by adopting a vertical evaporation method; then modifying distearoyl phosphatidyl ethanolamine-polyethylene glycol-carboxyl (DSPE) on the silicon dioxide colloidal crystal film, and separating and enriching the extracellular vesicles in the biological liquid by utilizing the affinity characteristic of the DSPE and a phospholipid bilayer; then constructing a reflection interference spectrum system, and detecting the extracellular vesicles in real time by utilizing optical thickness change caused in the process of separating the extracellular vesicles; according to the method, the extracellular vesicles in various biological liquids can be rapidly and efficiently separated, and real-time concentration and membrane protein expression quantity analysis can be carried out on the separated extracellular vesicles; the invention provides a rapid and low-cost integrated multifunctional analysis method for separation of extracellular vesicles of various body fluids.

A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.

Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and / or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.

Apparatus and associated methods relate to lyophilizing a solid phase composition (SPC). In an illustrative example, the SPC is received in a frozen state in a first packaging. The SPC may be, for example, transferred into a second packaging having a thermally conductive layer, mechanically distributed to a predetermined maximum thickness to form a block having at least one homogenous dimension, and provided with a heat source configured to communicate substantially all thermal energy to the SPC via the thermally conductive second layer. In some embodiments, the SPC may be maintained in the frozen state. For example, the lyophilized SPC may be transferred to a third packaging. Various embodiments may limit physical contacts with the SPC to the first packaging, the second packaging, and the third packaging. Various embodiments may advantageously maintain sanitation, retain nutrients of the SPC, and / or promote consistent results from the lyophilization process.

In one aspect, the disclosure relates to a sensor for predicting epileptic seizures in a subject. In an aspect, the sensor includes carbon nanotubes (CNTs) functionalized with organic molecules that can reversibly bind pre-seizure volatile organic compounds (VOCs) by IT-IT bonding, polar bonding, van der Waals interactions, and the like. The sensor can detect the pre-seizure VOCs from biological fluids including sweat, saliva, and breath, thus allowing the prediction of a seizure from 10 to 45 minutes before the seizure occurs, allowing a subject wearing the sensor to take actions to ensure safety and / or to alert caregivers. In an aspect, the sensor can be incorporated into a wearable device that also monitors vital signs such as heart rate, body temperature, skin impedance, and / or body movements in order to predict the type of epileptic seizure. Also disclosed are methods of making the sensors and methods for predicting epileptic seizures.

Highly efficient and rapid filtration-based methods for isolation and concentration of exosomes and extracellular vesicles from biological fluids, including urine, which utilize pretreatment, prefiltration, wash steps and isolation and concentration using the concentrating pipette are disclosed.

Disclosed are methods, materials and devices for approximating blood volume in a fluid obtained from a subject, such as blood in a biological fluid collected during a surgical procedure. In particular applications, methods of estimating blood volume in a sample as part of a method for estimating blood loss from a subject are provided. The methods provide for a much accelerated technique for determining blood volume and / or packed red blood cell units in a sample (within about 5-10 minutes). The method and devices (canisters) may include a red blood cell (RBC) flocculant, such as polyDADMAC, and employ a formula that includes a value for an approximate blood hematocrit, and an approximate red blood cell packing ratio (“η”) for a collection container. A Blood Indicator Panel (BIP) is also disclosed that comprises a material and / or panel that may be placed alongside or on a collection device, the material and / or panel being suitable for inscribing / printing thereon a series of graduated markings calibrated to coincide with an approximate volume of blood and / or unit measure of packed red blood cells. The series of graduated markings correspond to a calculation of blood volume or red blood cell volume in a fluid sample, for example, according to a defined formula. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) methods of measurement are also disclosed. Methods for detecting blood and determining approximate blood volume in a sample (e.g., a fluid biological sample), and kits for performing the methods, are also provided.

The invention relates to a bag system (1) for treating a biological fluid by means of electromagnetic irradiation, comprising at least one element consisting of an irradiation bag (2) for containing the biological fluid to be irradiated, said irradiation bag (2) being made of a material permeable to the electromagnetic radiation, said bag system further comprising one or more further elements, the one or more other elements are made of one or more materials formulated neither using phthalic acid esters nor using terephthalic acid esters.

A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

Assays for detecting the level of soluble UNC5C in a biological fluid sample from a patient, and the use of such levels as markers of neurodegenerative disease presence and / or severity are described. Antibodies and fragments thereof capable of binding to UNC5C, and the use of such antibodies for detecting the level of soluble UNC5C in a biological fluid sample from a patient are also described, as well as methods for detecting the level of soluble UNC5C in a biological fluid sample from a patient using anti-UNC5C antibodies in a clinical context.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

The invention discloses a method and a kit for determining various free fatty acids in body fluid by liquid chromatography-tandem mass spectrometry. The method comprises the following steps: pre-treating a biological fluid sample by introducing an isotope internal standard, protein precipitation, liquid-liquid extraction and an automatic pipetting platform, then separating an isomeride and an interferent through liquid chromatography, carrying out mass spectrometry scanning monitored by tandem mass spectrometry multi-reaction, making a standard curve by using a calibrator, and quantifying, and low, medium and high quality control products continuously monitor the performance of the method. The method realizes the purpose of simultaneously analyzing and detecting 22 free fatty acids and 20 D / 13C labeled isotope hormones in a sample by using the UPLC-MS / MS technology without using solid-phase extraction and non-derivatization treatment, has the advantages of rapidness, simplicity and convenience in operation, multiple detection types, high flux, high accuracy and low cost, can be applied to content detection of low-content free fatty acid level, and has a wide application prospect. The research on a lipid metabolism pathway is facilitated.

The application relates to the technical field of free radical detection, in particular to a high-sensitivity in-situ capture and detection method of organic free radicals based on a DIPPMPO probe and application, and the method comprises the following steps: adding a chemical probe DIPPMPO into a reaction system containing potential organic free radical precursors, so that the DIPPMPO and organic free radicals generated in a reaction process occur adduct reaction to form a DIPPMPO-free radical adduct which can be detected under liquid chromatography-mass spectrometry conditions; performing high performance liquid chromatography-quadrupole-time of flight mass spectrometry analysis on a mixed solution after the adduct reaction is completed, so that first mass spectrometry data and secondary mass spectrometry fragment information of the DIPPMPO-free radical adduct are obtained; and automatically processing the secondary mass spectrometry data, screening out parent ions with continuous neutral loss as potential DIPPMPO-free radical adduct candidate signals. The application does not need derivatization, is simple to operate, is broad-spectrum and high-efficiency, and can be applied to environmental water samples, biological fluids, chemical reaction liquids or drug metabolism systems.

A cartridge for analyzing a biological fluid, comprises an array of channels defining a plurality of analysis paths. Each channel is defined by at least two channel walls facing each other and defining a channel height. A wall of at least one channel has a step for defining on either side of the step: —a first segment of the channel wherein the wall has a first surface energy and a first elevation defining a first height of the channel; —a second segment of the channel wherein the wall has a second surface energy and a second elevation defining a second height of the channel. The first height of the channel and the first surface energy of the wall are greater than the second height of the channel and the second surface energy, respectively.

A method for activating a physiological signal sensing device through a handheld device to measure a physiological signal of an analyte in biological fluids is provided. The physiological signal sensing device includes a transmitter including a power unit, a switch unit, a magnetic field sensing unit and a processing unit. The method includes: establishing an inductive magnetic field between the handheld device and the transmitter, causing the magnetic field sensing unit to generate an inductive signal; in a first operating cycle, activating the switch unit by the inductive signal, causing the power unit to connect to the processing unit to activate the processing unit; providing an activation signal by the processing unit to turn on the switch unit; causing the switch unit to enter a self-maintaining state; and in a second operating cycle, connecting the power unit to the processing unit through the switch unit in the self-maintaining state.

To provide biological fluid purification using a biocompatible membrane.SOLUTION: An apparatus for integrated adaptive biological blood purification includes a function unit. The function unit is provided with: a membrane including a pipe surface and a filtration surface; a blood vessel channel system which is adhered to the blood vessel surface of the membrane and includes a first lumen space in fluid communication with the blood vessel surface of the membrane, a first end configured to be in fluid communication with a fluid supply part and to contact the same, and a second end configured to be in fluid communication with a filtration fluid outlet and to contact the same; and a filtration channel system which is adhered to the filtration surface of the membrane and includes a second lumen space in fluid communication with the filtration surface of the membrane and a third end configured to be in fluid communication with a filtrate outlet and to contact the same.SELECTED DRAWING: Figure 11