236 results about "Heparin" patented technology

The invention relates to the field of medical health and artificial intelligence, and discloses a cancer patient low-molecular heparin individualized dose dynamic optimization method based on reinforcement learning, and the method comprises the steps: S1, collecting multi-dimensional clinical data of a cancer patient, carrying out the preprocessing, carrying out the enhancement of the preprocessed data, and generating time sequence synthesis data; s2, based on the multi-dimensional clinical data and the time sequence synthesis data, constructing a reinforcement learning environment, including defining a state space, an action space and a reward function; s3, constructing an environment adaptive deep reinforcement learning EA-DRL model as a dose optimization model; performing model training and optimization in the reinforcement learning environment until convergence and obtaining an optimal dose decision strategy; and S4, inputting real-time dynamic clinical data of a patient to be decided into the trained dosage optimization model, and outputting individualized low molecular heparin LMWH administration dosage recommendation. Individualized precise administration is realized, and the treatment effect and the clinical medication safety are improved.

The invention belongs to the technical field of perioperative anticoagulation management, and particularly relates to a heparin dose-effect relationship modeling method, a heparin dose-effect relationship prediction system and a storage medium. The modeling method comprises the following steps: inputting clinical data from a single patient, wherein the clinical data comprises the administration dosage of heparin and a corresponding ACT measurement value; fitting different models suitable for the heparin dose-effect relationship based on the clinical data, and selecting an optimal model through cross validation; and re-training the optimal model by adopting all clinical data of a single patient to obtain the optimal model actually used for deployment. The invention also provides a system for predicting the heparin dose-effect relationship by using the model. Compared with a single model for predicting the heparin dosage-effect relationship, the method has higher accuracy, is beneficial to accurately controlling the heparin dosage of a patient, and has a very good application prospect in anticoagulation management in the perioperative period.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

The invention discloses a gel dressing for treating haemorrhoids and a preparation method of the gel dressing. The gel dressing is prepared from the following raw materials in parts by weight: modified chitosan, multifunctional lipidosome, fructo-oligosaccharide, hyaluronic acid, carbomer, glycerol and recombinant human epidermal growth factors. Chitosan has good film-forming property and antibacterial activity, when haemorrhoids are cracked and bleeding due to long-term constipation, a wound surface is in a high-pH and high-ROS environment, the modified chitosan forms a compact protective film on the ulcerated wound surface, the multifunctional lipidosome with contracted film holes and larger particle size is blocked outside, heparin molecules are grafted on the modified chitosan, and the heparin molecules are grafted on the surface of the wound surface. Recombinant human epidermal growth factors are allowed to pass through, and wound healing is accelerated. When the ulceration part is gradually healed, the pH and ROS level return to normal, the protective film of the modified chitosan is expanded, and the multifunctional liposome is diffused and degraded through the protective film to release the pepper extract, the borneol and the menthol. Fructo-oligosaccharide is added to maintain normal flora balance in the anorectum area.

The present invention discloses a high-precision chip-type micropump wearable precision syringe, which specifically relates to the technical field of medical devices. The present invention evacuates a hydraulic liquid supply tank to a vacuum to form a negative pressure, and then the needle tip of a liquid-filled injection needle pierces a heparin cap, so that the drug driving liquid is pressed into the hydraulic liquid supply tank and squeezes the piston of the pushing unit to move to one side. The volume of the hydraulic liquid supply tank increases, and the drug driving liquid enters the micropump unit through the micropump liquid inlet hole. Since the micropump unit swings to a fixed value each time, the drug driving liquid is accurately driven and controlled, and the injection volume is accurately controlled. The piston member in the cartridge bottle is pushed forward to quantitatively push the injection liquid, and the liquid drives the liquid, so that the infusion is accurate and reliable; the implanted spring pushes the indwelling needle catheter seat to be clamped into the convex ring cavity. Afterwards, the stainless steel needle is withdrawn, leaving only the soft indwelling needle catheter in the blood vessel. Injection is performed through the indwelling needle catheter without waiting for too long, thereby reducing the discomfort and pain caused to the patient.

A chitosan-heparin nanomotor and a method for producing same are disclosed. A STING agonist-encapsulated urease-based chitosan-heparin nanomotor delivers the STING agonist directly to bladder mucosal cells in the bladder, and thus can induce an immune response.

The present disclosure relates to a stable human platelet lysate composition; preferably a stable heparin-free human platelet lysate composition; methods for obtaining said composition and uses thereof.

The invention belongs to the field of biomedical materials and tissue engineering, and particularly relates to an injectable mineralized collagen bone repair composite material loaded with stem cell recruitment factors and osteogenic induction factors and a preparation method of the injectable mineralized collagen bone repair composite material. The composite material is composed of 50%-53% of mineralized collagen matrix particles, 15%-20% of SDF-1alpha loaded heparinized gelatin microspheres, 15%-20% of BMP-2 loaded PDA coated mesoporous silica particles, 8%-10% of an NHS-PEG-NHS cross-linking agent and 4%-6% of glycerin. The composite material can realize time-space sequential regulation and control of'collection first and then differentiation '; a bionic bone matrix microenvironment is provided through the mineralized collagen matrix; the problems of two-factor release conflict and stability are solved; in-vitro experiments show that the material can significantly promote stem cell migration and osteogenic differentiation, and animal experiments prove that the material can recover 82-88% of mechanical properties of bone defect parts. The invention solves the technical problems of insufficient stem cell collection, low osteogenic differentiation efficiency and uncontrollable factor release of the existing bone repair material.

The invention belongs to the technical field of medical instruments, and provides a painless microneedle patch loaded with low-molecular-weight heparin and a preparation method of the painless microneedle patch in order to solve the problems that most existing microneedle products aim at small-molecular drugs, lack protection and slow release design for the low-molecular-weight heparin, low drug loading efficiency, poor activity retention and incapability of adapting to long-term anticoagulation treatment. The painless micro-needle patch comprises a substrate layer and a composite micro-needle, the composite microneedle is composed of a plurality of microneedles arranged in an array and fixed on one surface of the substrate layer and a low-molecular heparin delivery material loaded in the microneedles. According to the painless microneedle patch loaded with the low-molecular heparin, efficient percutaneous delivery of drugs can be achieved, local adverse reactions are reduced, the operation process is simplified, and the long-term drug use requirements under different anticoagulation scenes are met.

The invention relates to the technical field of blood purification, in particular to an anticoagulation pump which comprises a bottom plate, an injection pushing mechanism and a liquid medicine feeding mechanism, a hemodialysis machine is fixedly installed on the upper side of the bottom plate, a blood drawing pipe is fixedly arranged on one side of the hemodialysis machine, and an infusion tube is fixedly arranged on the other side of the hemodialysis machine; a round seat frame and a box body are fixedly connected to the upper side of the bottom plate, an injector is clamped in the round seat frame, heparin can be supplemented to the injector through the injection pushing mechanism, the injector, the box body and a piston rod, heparin can be continuously injected, blood is prevented from being coagulated in the hemodialysis machine, and the hemodialysis efficiency is improved. The hemodialysis purification device has the advantages that smooth flow of blood is guaranteed, the injector does not need to be replaced, time and labor are saved during operation, long-time interruption of heparin injection is avoided, improvement of the anticoagulation effect of hemodialysis purification is facilitated, the hemodialysis purification process can be smoothly performed, and meanwhile, the working efficiency of the anticoagulation pump is improved.

The invention discloses a PET-CT (positron emission tomography-computed tomography) radiopharmaceutical closed automatic dispensing and dosing machine which comprises a machine base and an injection bin fixedly mounted on the machine base, an air cylinder mechanism is fixedly mounted at the top of the back of the injection bin, and a closed box is fixedly mounted on one side of the injection bin. And a transmission mechanism pushed by the air cylinder mechanism is installed in the closed box in a sliding mode, a mechanical clamping mechanism is installed at the bottom of the transmission mechanism in a transmission mode, and an arm support is fixedly installed at the position, located at the placing opening, in the injection bin. According to the invention, the mechanical clamping mechanism repeatedly acts to clamp the disposable syringe, the problem of more pipeline consumables is solved by directly adopting the mechanical clamping mechanism to extract liquid medicine at a fixed point and inject the liquid medicine at a fixed point, meanwhile, the flowing time of the stock solution in the pipeline is also reduced, the disposable syringe directly injects the stock solution into the heparin cap, and the operation is simple and convenient. And the accuracy of the nuclide value is ensured to the greatest extent.

The invention relates to a heparin drug consistency evaluation method, system and device, and belongs to the technical field of drug quality control. Comprising the following steps: carrying out disaccharide analysis, oligosaccharide analysis and two-dimensional liquid phase analysis on a selected standard preparation to respectively obtain corresponding peak parameters, and constructing a qualitative database and a quantitative database according to the peak parameters; acquiring the chromatographic data of the reference preparation treated under the same condition as the sample to be detected, and performing consistency evaluation on the chromatographic data and the two databases; wherein the consistency evaluation comprises the following steps: acquiring chromatographic data of a reference preparation, performing automatic integration on the chromatographic data, and performing automatic attribution on components by utilizing a qualitative database to respectively obtain two peak contents; obtaining samples in a quantitative database; according to the sample, carrying out consistency evaluation on the two peak contents; and if yes, acquiring the chromatographic data of a large batch of samples to be detected and carrying out consistency evaluation on the chromatographic data. According to the method, the chromatographic data processing process is simplified, and the efficiency, accuracy and reliability of quality evaluation of the heparin drugs are improved.

The application discloses a kind of consumable conveying devices, comprising: guide wire conveying unit, guide wire is contained in guide wire coil and passes between the pair of guide wire guide wheels, with the rotation of guide wire guide wheel, guide wire is driven forward or backward to retreat;And catheter / stent conveying unit, catheter / stent is contained in catheter / stent coil and passes between the pair of catheter / stent guide wheels, with the rotation of catheter / stent guide wheel, catheter / stent is driven forward or backward to retreat;Wherein the proximal end of guide wire coil is provided with guide wire wetting section, at guide wire wetting section, the upper end side wall of guide wire coil is provided with drop opening, heparin or physiological saline is dropped through drop opening, to wet guide wire in guide wire coil.The application conveys guide wire, catheter / stent and other medical instruments by conveying device, improves the efficiency of guide wire, catheter or stent into human body, reduces the pollution in the preoperative preparation process of guide wire, catheter or stent, and then simplifies the operation of doctor.

The present invention provides for the synthesis of intermediate molecular weight heparin.

The invention provides a small-cavity surgical robot with an anti-blocking mechanism, and relates to the technical field of surgical robotics.The small-cavity surgical robot comprises a mechanical arm, an operation platform is rotationally installed on the mechanical arm, an operation instrument used for conducting an operation on a patient is arranged on the operation platform, and a fixing frame is fixedly installed on the operation platform; a circular space between the inner pipe and the outer pipe is divided into two independent areas, the two independent areas are matched with the two connecting pipelines on the outer pipe and the connected micro peristaltic pump, and therefore the inner pipe and the outer pipe can be separated into two independent areas. By means of the design, normal saline and a low-concentration heparin solution can be conveyed respectively, the washing requirement in a conventional operation is met, anticoagulation treatment can be provided for an operation scene with the high blood coagulation risk, the application range of the surgical robot is greatly widened, surgical operation is more targeted and flexible, and the surgical robot is suitable for being popularized and used. And individual differences of different patients can be effectively handled.

The application relates to the technical field of medical dressing preparation, and discloses a hemostatic, healing-promoting and antibacterial foam dressing and a preparation method thereof. The method uses sodium alginate and carboxymethyl chitosan as a composite polysaccharide matrix, mixes the two, adds a calcium chloride solution to crosslink a porous gel support, and then carries out freeze-drying to obtain a porous framework; gelatin and polyvinyl alcohol can be further added to enhance the mechanical strength, zeolite particles loaded with silver ions are added to achieve antibacterial performance, epidermal growth factor release microspheres are added to promote healing, and the dressing can be further subjected to heparinization, plasma surface modification, thrombin addition, salt precipitation pore formation and sterilization treatment. The dressing prepared by the method has the functions of synergistic hemostasis, antibiosis and healing promotion, has good biocompatibility and suitable mechanical strength, and has a simple preparation process, and can be used for various wound care.

The utility model provides an infusion channel cap fixing device which comprises a fixing body. Wherein the fixing body comprises a main body piece and a fixing piece integrally formed on the main body piece; the main body piece is suitable for being detachably installed on the main body channel, the fixing piece is suitable for being detachably installed on the branch channel, and after the fixing piece is installed on the branch channel, the sealing cap can be fixed to the branch channel. When the infusion channel cap fixing device is used, the main body piece is installed on the main body channel of the heparin cap, the fixing piece is installed on the branch channel of the heparin cap, and the sealing cap on the branch channel makes contact with the inner wall of the top of the fixing piece. When the branch channel is used, the fixing body is detached firstly, and then the sealing cap is taken down from the branch channel. After the infusion channel cap fixing device is fixed on a heparin cap, a sealing cap can be fixed on a branch channel, so that the sealing cap can be prevented from being pressed or accidentally falling off.

The invention belongs to the technical field of medical materials, and particularly relates to an antibacterial and anticoagulant dual-function coating, a preparation method thereof and a needle head with the antibacterial and anticoagulant dual-function coating. S200, a PDPA coating is prepared; s300, grafting the heparin; s400, carrying out NO (nitric oxide) loading; the antibacterial and anticoagulant bifunctional coating prepared by the method has excellent antibacterial and anticoagulant functions, is used for hemodialysis, can effectively inhibit arteriovenous needle blockage and prevent bacterial infection, and is firm in adhesion and not easy to fall off.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The present invention is directed to a homeopathic complex for use in the treatment of various diseases or disorders, including use as an anti-infective agent and / or in the regeneration of diseased or damaged tissue. Ideally, the anti-infective homeopathic complex of the invention may comprise a homeopathic tincture or dilutions thereof of Hepar sulphuris calcareum or other similar profiled Calcarea or Sulphur salt or acid, Lachesis muta or other remedy with a similar profile, Mercurius solubilis or similar mercury containing remedy and Silica or other silica containing compounds.

The present invention relates to compressed hemostatic tablets or forms comprising a fibrous nonwoven oxidized cellulose (OC or ORC) multilayer material compressed into a shape-stable tablet, further comprising a calcium salt, and capable of rapidly expanding upon contact with blood or plasma. The compressed forms may further comprise multi-arm PEG-SG and are dimensionally stable, preferably in terms of length and width, for at least 48 hours after compression. In some embodiments, upon contact with blood, the compressed forms expand to 1.5 to 5 times their tablet length in 5 seconds, to 2 to 6 times their tablet length in 20 seconds, and to 3 to 6 times their tablet length in 5 minutes. The compressed forms are effective for hemostasis in heparinized blood.

The utility model relates to the field of guide wire fixing, in particular to an intraoperative storage device for a guide wire. The device comprises a fixing seat, the bottom face of the fixing seat is provided with a pasting face used for being attached to an operating table, the fixing seat is composed of a first clamping part and a second clamping part, the first clamping part and the second clamping part are tightly attached to form a longitudinal clamping seam with clamping force, and the longitudinal clamping seam is used for fixing a guide wire behind a circle disc; a sponge layer is arranged on the inner side of the crack. A water injection hole communicated with the longitudinal crack is formed in the upper side of the fixing base and is a one-way valve. Meanwhile, one end of the guide wire is reserved when the guide wire is taken out again, and heparin normal saline can be poured into the water injection hole through the needle cylinder to clean blood stains on the surface of the guide wire when the other end of the guide wire is drawn out. The device is simple in structure, the management convenience in the guide wire operation can be effectively improved, and the guide wire storage efficiency is improved by optimizing the fixing and cleaning functions.

To provide a factor Xa reagent.SOLUTION: Exemplary compositions include Factor Xa, a substrate, one or more guanidine derivatives, and in some cases heparin. An exemplary method of detecting an anticoagulant in a sample includes combining or contacting a composition with a sample and measuring factor Xa activity based on substrate status. The composition modulates the activity of factor Xa in the sample, and the modulation includes a reduction in the rate of clotting of the sample caused by factor Xa. The presence of an anticoagulant is based on the activity of factor Xa.SELECTED DRAWING: None

The present invention relates to a method for preparing a multilayer heparin conjugate coating on a substrate, the method promoting good adhesion to the substrate surface and increasing the number of available heparin molecules.

To provide a topical scalp composition that can suppress scalp odor while reducing scalp itching.SOLUTION: Provided is a topical scalp composition comprising (A) a heparin-like substance and (B) diphenhydramine and / or a salt thereof, the composition having a viscosity of 140 Pa s or less.SELECTED DRAWING: None

The application relates to the technical field of indwelling needles, and discloses an indwining needle capable of preventing blood backflow, which comprises a venous tube, a filling pipeline fixedly connected to the top of the venous tube, a hose fixedly connected to the outside of the filling pipeline, a mixed liquid tube fixedly connected to one end of the hose, a transfusion tube fixedly connected to one end of the mixed liquid tube, a heparin cap fixedly connected to the other end of the mixed liquid tube, a drainage ball movably connected between the filling pipeline and the hose, and second anastomosis walls for anastomosing the drainage ball formed by the concave shapes of the two sides of the replacement ring, a drainage hole arranged on the drainage ball, the filling pipeline communicated with the hose through the drainage hole, and a three-labium sealing plate movably connected to the inside of the filling pipeline. The indwining needle capable of preventing blood backflow is characterized in that blood in the hose flows into the inside of the filling pipeline, and when the liquid level in the inside of the filling pipeline drops, the three-labium sealing plate slowly drops to re-contact the drainage ball, so that the channel between the filling pipeline and the hose is closed, thereby preventing the possibility of blood backflow in the pipeline.

The application discloses a controllable degradation high-corrosion-resistance medical magnesium-aluminum alloy blood vessel stent and a preparation method thereof. The method comprises the following steps: subjecting magnesium alloy ingots containing Al, Zn, Ca and Mn to homogenization treatment, hot extrusion, cold drawing and recrystallization annealing to obtain low-aluminum magnesium-aluminum alloy microtubular materials containing aluminum second-phase non-continuous discrete distribution; after laser cutting, deburring, electrochemical polishing and surface activation, an inner layer rich in MgF2 and an outer layer rich in calcium and phosphorus are sequentially constructed; a polydopamine interface anchoring layer is formed, and a degradable polymer sealing liquid containing a heparinized hyaluronic acid-REDV peptide composite active component is coated to form an active flexible sealing layer after solidification. The stent obtained by the application has good corrosion resistance, controllable degradation, mechanical support retention capacity and endothelial repair promotion performance.

This utility model belongs to the field of medical device technology, specifically relating to a double-lumen central venous catheter with anti-wall adhesion and anticoagulation functions, including an extension tube, a double-lumen catheter, and a connector; the extension tube is connected to the double-lumen catheter through the connector; the double-lumen catheter is divided into two inlet lumens by a diaphragm, and the two inlet lumens are connected to two corresponding extension tubes; a side hole and a main hole are provided at the end of the double-lumen catheter, and the end of the double-lumen catheter has a C-shaped segment, with the side hole located on the concave side of the C-shaped segment, and the main hole located at the end of the double-lumen catheter. The C-shaped segment in this design reduces the occurrence of the side hole adhering to the blood vessel wall, reducing the probability of local coagulation and thrombosis when used for pediatric hemodialysis blood drainage; the biomimetic sharkskin microgrooves etched on the outside of the double-lumen catheter reduce resistance to blood flow and thrombus formation; the biomimetic sharkskin microgrooves can be filled with covalently grafted sulfonated heparin-hydrogel, continuously releasing anticoagulant factors, further reducing the formation of wall-attached thrombi.

This invention relates, inter alia, to an immunogenic fragment of a Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae (SEQ ID NO: 1) for the prevention and treatment of Neisseria gonorrhoeae or gonococcal- or meningococcal-associated diseases and conditions. In some embodiments, the immunogenic fragment corresponds to a C-terminal fragment of the protein (SEQ ID NO: 2).

The application discloses a tumor department-preventing-skin-swelling-at-needle-inserting-site indwelling needle auxiliary device, and relates to the technical field of medical devices, which comprises a first support frame, a cover plate, a fixed plate, an elastic clamping block, a fixed block, an indwelling needle and a first inclined frame, etc., the upper side of the first support frame is rotationally connected with the cover plate, the front side of the bottom of the cover plate is fixedly connected with the fixed plate, the rear side of the bottom of the cover plate is slidingly connected with the elastic clamping block used for clamping a heparin cap, the rear side of the bottom of the cover plate is fixedly connected with the fixed block, the indwelling needle is arranged between the elastic clamping block and the fixed block, and the rear side of the fixed plate is slidingly connected with the first inclined frame. The heparin cap is inserted between the elastic clamping block and the fixed block, the first clamping plate and the fixed plate clamp the catheter, then the inner needle tube is pinched, the inner needle is inserted into the patient's hand, the clamping effect is realized, and the catheter and the inner needle are prevented from moving to cause the skin swelling at the needle-inserting site.