353 results about "Heparin" patented technology

The invention discloses photocuring hydrogel capable of being combined with cytokines and used for tumor organoid culture and application, and belongs to the technical field of organoid culture. According to the invention, the hydrogel which can fix cells, can be combined with cell factors and can realize organoid recovery is developed through norbornene modified heparin, norbornene modified gelatin, sulfydryl four-arm polyethylene glycol, glucan, matrix metal protein peptidomimetic MMP and a photoinitiator. The hydrogel can be used for directly preparing organoids, heparin of various structures can be used, the cost is reduced, the modified heparin can bind factors or matrix protein and can controllably release the factors, the modified gelatin provides amino acid energy for collagen hydrolysate, and the hydrogel is formed by photocuring in a stepwise polymerization mode, is controllable in structure and can be used for preparing collagen collagen. The adjustable bionic modulus and the adjustable bionic stress relaxation are realized. The hydrogel disclosed by the invention can be used for culturing various organs, overcomes the problems of low repeatability, instability and the like in the prior art, and is suitable for the fields of tumor drug evaluation and the like.

The invention discloses a heparin impurity detection method and system based on a Raman spectrum. Impurities in heparin production are efficiently detected through a Raman spectrum technology, and a production process is optimized. The method comprises the following steps: firstly, obtaining original Raman spectrum data of a heparin production sample, performing quality analysis, and optimizing data to obtain parameters; extracting spectral data features, and generating a three-dimensional feature matrix; detecting abnormal spectral characteristics by using a density clustering algorithm, identifying impurities, and obtaining impurity detection data; and the impurity change trend is analyzed in combination with production timestamp data, and production process parameters are optimized. According to the method, the impurities can be accurately detected in real time, the production process is dynamically optimized, and the quality and safety of a heparin product are ensured. The system realizes efficient quality control, and has a wide application prospect, especially in the field of biological pharmacy.

The invention relates to the field of medical health and artificial intelligence, and discloses a cancer patient low-molecular heparin individualized dose dynamic optimization method based on reinforcement learning, and the method comprises the steps: S1, collecting multi-dimensional clinical data of a cancer patient, carrying out the preprocessing, carrying out the enhancement of the preprocessed data, and generating time sequence synthesis data; s2, based on the multi-dimensional clinical data and the time sequence synthesis data, constructing a reinforcement learning environment, including defining a state space, an action space and a reward function; s3, constructing an environment adaptive deep reinforcement learning EA-DRL model as a dose optimization model; performing model training and optimization in the reinforcement learning environment until convergence and obtaining an optimal dose decision strategy; and S4, inputting real-time dynamic clinical data of a patient to be decided into the trained dosage optimization model, and outputting individualized low molecular heparin LMWH administration dosage recommendation. Individualized precise administration is realized, and the treatment effect and the clinical medication safety are improved.

The disclosure provides an extracorporeal devices, systems and methods for removing a pathogen or a toxin from a biological fluid of a subject comprising contacting a biological fluid from the subject with a loosely packed bed of adsorption media, such as a fluidized bed, wherein the adsorption media comprises heparin, to remove the pathogen or the toxin to form a treated biological fluid; and infusing the treated fluid into the subject.

The invention relates to the technical field of biological medicine, in particular to a targeting nanoparticle and a preparation method and application thereof. The targeted nano-particle designed and synthesized by the invention comprises a nano-liposome and low-molecular heparin entrapped in the nano-liposome, wherein the surface of the nano-liposome is modified with CREKA peptide. Wherein the CREKA peptide can target fibrinogen in thrombus and specifically recognize FN1 at the thrombus part, so that LMWH is delivered to the thrombus part in a targeted manner, the local antithrombotic effect is improved, meanwhile, the risks of extra bleeding and toxicity are reduced to the maximum extent, and the limitation of traditional LMWH is solved.

The invention belongs to the technical field of perioperative anticoagulation management, and particularly relates to a heparin dose-effect relationship modeling method, a heparin dose-effect relationship prediction system and a storage medium. The modeling method comprises the following steps: inputting clinical data from a single patient, wherein the clinical data comprises the administration dosage of heparin and a corresponding ACT measurement value; fitting different models suitable for the heparin dose-effect relationship based on the clinical data, and selecting an optimal model through cross validation; and re-training the optimal model by adopting all clinical data of a single patient to obtain the optimal model actually used for deployment. The invention also provides a system for predicting the heparin dose-effect relationship by using the model. Compared with a single model for predicting the heparin dosage-effect relationship, the method has higher accuracy, is beneficial to accurately controlling the heparin dosage of a patient, and has a very good application prospect in anticoagulation management in the perioperative period.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

The invention discloses a gel dressing for treating haemorrhoids and a preparation method of the gel dressing. The gel dressing is prepared from the following raw materials in parts by weight: modified chitosan, multifunctional lipidosome, fructo-oligosaccharide, hyaluronic acid, carbomer, glycerol and recombinant human epidermal growth factors. Chitosan has good film-forming property and antibacterial activity, when haemorrhoids are cracked and bleeding due to long-term constipation, a wound surface is in a high-pH and high-ROS environment, the modified chitosan forms a compact protective film on the ulcerated wound surface, the multifunctional lipidosome with contracted film holes and larger particle size is blocked outside, heparin molecules are grafted on the modified chitosan, and the heparin molecules are grafted on the surface of the wound surface. Recombinant human epidermal growth factors are allowed to pass through, and wound healing is accelerated. When the ulceration part is gradually healed, the pH and ROS level return to normal, the protective film of the modified chitosan is expanded, and the multifunctional liposome is diffused and degraded through the protective film to release the pepper extract, the borneol and the menthol. Fructo-oligosaccharide is added to maintain normal flora balance in the anorectum area.

The invention belongs to the technical field of biology, and discloses a fusion type polypeptide for improving the activity of umbilical cord mesenchymal stem cells and application of the fusion type polypeptide. The amino acid sequence of the fusion type polypeptide provided by the invention is any one sequence as shown in SEQ ID NO.1-3. The fusion type polypeptide is obtained by integrating an extracellular matrix amino acid sequence and a heparin amino acid sequence. The umbilical cord mesenchymal stem cells obtained by culturing the fusion type polypeptide have good multiplication capacity, can promote expression of the Ki67 gene and inhibit aging of the umbilical cord mesenchymal stem cells, and have wide application prospects.

The invention discloses an artificial blood vessel and a preparation method thereof, and the preparation method comprises the following steps: uniformly mixing an erythrocyte ghost suspension and melanin nanoparticles to obtain a mixed solution; carrying out ultrasonic treatment and extrusion on the mixed solution to obtain a melanin nano-vesicle solution; carrying out electrostatic spinning on the polycaprolactone solution to obtain a polycaprolactone electrostatic spinning blood vessel; soaking the polycaprolactone electrostatic spinning blood vessel in an ethylenediamine solution, and then washing the polycaprolactone electrostatic spinning blood vessel with a phosphate buffer solution; then soaking in a 4-morpholine ethanesulfonic acid solution; finally, carrying out heparinization in a 4-morpholine ethanesulfonic acid solution containing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and heparin; and incubating the heparin-modified polycaprolactone electrostatic spinning blood vessel in the melanin nano-vesicle solution to obtain the artificial blood vessel. The melanin nano-vesicles are modified, so that the anticoagulation performance of erythrocyte membranes is reserved, and meanwhile, the scavenging capacity of melanin nano-particles on reactive oxygen free radicals is reserved.

The present invention discloses a high-precision chip-type micropump wearable precision syringe, which specifically relates to the technical field of medical devices. The present invention evacuates a hydraulic liquid supply tank to a vacuum to form a negative pressure, and then the needle tip of a liquid-filled injection needle pierces a heparin cap, so that the drug driving liquid is pressed into the hydraulic liquid supply tank and squeezes the piston of the pushing unit to move to one side. The volume of the hydraulic liquid supply tank increases, and the drug driving liquid enters the micropump unit through the micropump liquid inlet hole. Since the micropump unit swings to a fixed value each time, the drug driving liquid is accurately driven and controlled, and the injection volume is accurately controlled. The piston member in the cartridge bottle is pushed forward to quantitatively push the injection liquid, and the liquid drives the liquid, so that the infusion is accurate and reliable; the implanted spring pushes the indwelling needle catheter seat to be clamped into the convex ring cavity. Afterwards, the stainless steel needle is withdrawn, leaving only the soft indwelling needle catheter in the blood vessel. Injection is performed through the indwelling needle catheter without waiting for too long, thereby reducing the discomfort and pain caused to the patient.

The hemodialysis device comprises a dialysis equipment body, a dialysate tank and a waste liquid tank, a dialyzer, a blood pump and a heparin pump are arranged on the outer side of the dialysis equipment body, and the top and the bottom of the dialyzer communicate with an arterial communicating pipe and a venous communicating pipe correspondingly; the lower portion and the upper portion of the dialyzer are communicated with a dialysate inlet pipe and a waste liquid discharge pipe respectively, a groove is formed in the dialysis equipment body, the blood pump comprises a driving motor, a sliding groove is formed in the outer portion of the dialysis equipment body, and a pushing plate is jointly slidably connected into the groove and the sliding groove. And a linkage mechanism is arranged between the pushing plate and the output shaft of the driving motor. When the blood pump is started to enable blood in the body of a patient to enter the dialysate tank through the arterial communicating pipe to be purified, the push plate can slowly push the piston rod upwards to squeeze a heparin agent in the cylinder into the arterial communicating pipe; and the supply amount of the heparin agent can be automatically adjusted according to the flow of blood entering the arterial communicating pipe.

A chitosan-heparin nanomotor and a method for producing same are disclosed. A STING agonist-encapsulated urease-based chitosan-heparin nanomotor delivers the STING agonist directly to bladder mucosal cells in the bladder, and thus can induce an immune response.

The utility model discloses CRRT equipment, and relates to the technical field of medical instruments. The CRRT equipment comprises a plurality of functional modules, and each functional module is provided with an independent control display unit and an independent driving pump and can independently realize respective functions. Each function module is relatively small in size, small in occupied space and convenient to carry and place in special scenes such as an ambulance, a mountain top disaster relief area, a battlefield first-line, a ship and a warship for use. The heparin pump module, the dialysate pump module, the displacement liquid pump module, the blood pump module and the waste liquid pump module can be independently used as independent modules and can also be used in a combined mode. During combined use, the heparin pump module, the dialysate pump module, the displacement liquid pump module and the waste liquid pump module are all in communication connection with the blood pump module and are used for blood purification treatment; when the medical transfusion bag is independently used, various requirements of emergency blood transfusion, transfusion and nutrition delivery in special scenes such as ambulances, mountain top disaster relief areas, first-line battlefields, ships, warships and the like can be met.

The present disclosure relates to a stable human platelet lysate composition; preferably a stable heparin-free human platelet lysate composition; methods for obtaining said composition and uses thereof.

The invention belongs to the field of biomedical materials and tissue engineering, and particularly relates to an injectable mineralized collagen bone repair composite material loaded with stem cell recruitment factors and osteogenic induction factors and a preparation method of the injectable mineralized collagen bone repair composite material. The composite material is composed of 50%-53% of mineralized collagen matrix particles, 15%-20% of SDF-1alpha loaded heparinized gelatin microspheres, 15%-20% of BMP-2 loaded PDA coated mesoporous silica particles, 8%-10% of an NHS-PEG-NHS cross-linking agent and 4%-6% of glycerin. The composite material can realize time-space sequential regulation and control of'collection first and then differentiation '; a bionic bone matrix microenvironment is provided through the mineralized collagen matrix; the problems of two-factor release conflict and stability are solved; in-vitro experiments show that the material can significantly promote stem cell migration and osteogenic differentiation, and animal experiments prove that the material can recover 82-88% of mechanical properties of bone defect parts. The invention solves the technical problems of insufficient stem cell collection, low osteogenic differentiation efficiency and uncontrollable factor release of the existing bone repair material.

The invention belongs to the technical field of medical instruments, and provides a painless microneedle patch loaded with low-molecular-weight heparin and a preparation method of the painless microneedle patch in order to solve the problems that most existing microneedle products aim at small-molecular drugs, lack protection and slow release design for the low-molecular-weight heparin, low drug loading efficiency, poor activity retention and incapability of adapting to long-term anticoagulation treatment. The painless micro-needle patch comprises a substrate layer and a composite micro-needle, the composite microneedle is composed of a plurality of microneedles arranged in an array and fixed on one surface of the substrate layer and a low-molecular heparin delivery material loaded in the microneedles. According to the painless microneedle patch loaded with the low-molecular heparin, efficient percutaneous delivery of drugs can be achieved, local adverse reactions are reduced, the operation process is simplified, and the long-term drug use requirements under different anticoagulation scenes are met.

The invention discloses double-network hydrogel based on chlorogenic acid as well as a preparation method and application of the double-network hydrogel, and belongs to the technical field of wound dressings. A first network of the double-network hydrogel based on the chlorogenic acid is formed by coordination of the chlorogenic acid and Zn < 2 + >, and CA and Zn < 2 + > can be quickly released in inflammation and proliferation stages, so that the effects of resisting bacteria, resisting oxidation, diminishing inflammation and generating blood vessels are achieved; the second network is formed by covalent crosslinking of heparin grafted gelatin and genipin, crosslinking of gelatin and genipin can enhance the mechanical strength, heparin is grafted into gelatin, bFGF can be stably added, the release time of bFGF at a wound part can be prolonged, and bFGF is slowly released in proliferation and remodeling stages, so that scars are prevented from being formed; in-vivo studies of MRSA infected diabetic mouse models and rabbit ear hyperplastic scar models show that the dual-network hydrogel can significantly promote healing of scar-free wounds. The programmed release function of the CZGF hydrogel plays a key role in accelerating chronic wound healing and preventing scar formation.

The invention relates to the technical field of blood purification, in particular to an anticoagulation pump which comprises a bottom plate, an injection pushing mechanism and a liquid medicine feeding mechanism, a hemodialysis machine is fixedly installed on the upper side of the bottom plate, a blood drawing pipe is fixedly arranged on one side of the hemodialysis machine, and an infusion tube is fixedly arranged on the other side of the hemodialysis machine; a round seat frame and a box body are fixedly connected to the upper side of the bottom plate, an injector is clamped in the round seat frame, heparin can be supplemented to the injector through the injection pushing mechanism, the injector, the box body and a piston rod, heparin can be continuously injected, blood is prevented from being coagulated in the hemodialysis machine, and the hemodialysis efficiency is improved. The hemodialysis purification device has the advantages that smooth flow of blood is guaranteed, the injector does not need to be replaced, time and labor are saved during operation, long-time interruption of heparin injection is avoided, improvement of the anticoagulation effect of hemodialysis purification is facilitated, the hemodialysis purification process can be smoothly performed, and meanwhile, the working efficiency of the anticoagulation pump is improved.

The invention discloses a PET-CT (positron emission tomography-computed tomography) radiopharmaceutical closed automatic dispensing and dosing machine which comprises a machine base and an injection bin fixedly mounted on the machine base, an air cylinder mechanism is fixedly mounted at the top of the back of the injection bin, and a closed box is fixedly mounted on one side of the injection bin. And a transmission mechanism pushed by the air cylinder mechanism is installed in the closed box in a sliding mode, a mechanical clamping mechanism is installed at the bottom of the transmission mechanism in a transmission mode, and an arm support is fixedly installed at the position, located at the placing opening, in the injection bin. According to the invention, the mechanical clamping mechanism repeatedly acts to clamp the disposable syringe, the problem of more pipeline consumables is solved by directly adopting the mechanical clamping mechanism to extract liquid medicine at a fixed point and inject the liquid medicine at a fixed point, meanwhile, the flowing time of the stock solution in the pipeline is also reduced, the disposable syringe directly injects the stock solution into the heparin cap, and the operation is simple and convenient. And the accuracy of the nuclide value is ensured to the greatest extent.

The invention relates to a heparin drug consistency evaluation method, system and device, and belongs to the technical field of drug quality control. Comprising the following steps: carrying out disaccharide analysis, oligosaccharide analysis and two-dimensional liquid phase analysis on a selected standard preparation to respectively obtain corresponding peak parameters, and constructing a qualitative database and a quantitative database according to the peak parameters; acquiring the chromatographic data of the reference preparation treated under the same condition as the sample to be detected, and performing consistency evaluation on the chromatographic data and the two databases; wherein the consistency evaluation comprises the following steps: acquiring chromatographic data of a reference preparation, performing automatic integration on the chromatographic data, and performing automatic attribution on components by utilizing a qualitative database to respectively obtain two peak contents; obtaining samples in a quantitative database; according to the sample, carrying out consistency evaluation on the two peak contents; and if yes, acquiring the chromatographic data of a large batch of samples to be detected and carrying out consistency evaluation on the chromatographic data. According to the method, the chromatographic data processing process is simplified, and the efficiency, accuracy and reliability of quality evaluation of the heparin drugs are improved.

The application discloses a kind of consumable conveying devices, comprising: guide wire conveying unit, guide wire is contained in guide wire coil and passes between the pair of guide wire guide wheels, with the rotation of guide wire guide wheel, guide wire is driven forward or backward to retreat;And catheter / stent conveying unit, catheter / stent is contained in catheter / stent coil and passes between the pair of catheter / stent guide wheels, with the rotation of catheter / stent guide wheel, catheter / stent is driven forward or backward to retreat;Wherein the proximal end of guide wire coil is provided with guide wire wetting section, at guide wire wetting section, the upper end side wall of guide wire coil is provided with drop opening, heparin or physiological saline is dropped through drop opening, to wet guide wire in guide wire coil.The application conveys guide wire, catheter / stent and other medical instruments by conveying device, improves the efficiency of guide wire, catheter or stent into human body, reduces the pollution in the preoperative preparation process of guide wire, catheter or stent, and then simplifies the operation of doctor.

The invention relates to saxifraga stolonifera polysaccharide and application thereof in preparation of complement inhibitors or anti-inflammatory drugs. Based on activity guidance, it is found that a water extraction part of saxifraga stolonifera has good anti-complement activity when experimental screening is conducted on the anti-complement active part of saxifraga stolonifera, graded alcohol precipitation is conducted on the water extraction part, the activity of crude polysaccharide precipitated by 90 alcohol (90% ethyl alcohol) is higher than that of crude polysaccharide precipitated by 75 alcohol (75% ethyl alcohol), and the anti-complement activity of the crude polysaccharide precipitated by 90 alcohol is higher than that of a positive drug (heparin). On the basis, five neutral heteropolysaccharides with anticomplement activity, namely SSP-90-1, SSP-90-2, SSP-90-3, SSP-90-4 or SSP-90-5, are separated from the 90 alcohol precipitation crude polysaccharide. Compared with the prior art, the structural characteristics of the saxifraga stolonifera polysaccharide are represented, and the preparation method of the saxifraga stolonifera polysaccharide and the application of the saxifraga stolonifera polysaccharide in preparation of complement inhibitors and anti-inflammatory drugs are provided. The invention verifies the anti-complement activity of the saxifraga stolonifera polysaccharide and the therapeutic effect of the saxifraga stolonifera polysaccharide on lipopolysaccharide (LPS)-induced acute lung injury and systemic inflammatory response.

The present invention provides for the synthesis of intermediate molecular weight heparin.

The invention provides a small-cavity surgical robot with an anti-blocking mechanism, and relates to the technical field of surgical robotics.The small-cavity surgical robot comprises a mechanical arm, an operation platform is rotationally installed on the mechanical arm, an operation instrument used for conducting an operation on a patient is arranged on the operation platform, and a fixing frame is fixedly installed on the operation platform; a circular space between the inner pipe and the outer pipe is divided into two independent areas, the two independent areas are matched with the two connecting pipelines on the outer pipe and the connected micro peristaltic pump, and therefore the inner pipe and the outer pipe can be separated into two independent areas. By means of the design, normal saline and a low-concentration heparin solution can be conveyed respectively, the washing requirement in a conventional operation is met, anticoagulation treatment can be provided for an operation scene with the high blood coagulation risk, the application range of the surgical robot is greatly widened, surgical operation is more targeted and flexible, and the surgical robot is suitable for being popularized and used. And individual differences of different patients can be effectively handled.

The application relates to the technical field of medical dressing preparation, and discloses a hemostatic, healing-promoting and antibacterial foam dressing and a preparation method thereof. The method uses sodium alginate and carboxymethyl chitosan as a composite polysaccharide matrix, mixes the two, adds a calcium chloride solution to crosslink a porous gel support, and then carries out freeze-drying to obtain a porous framework; gelatin and polyvinyl alcohol can be further added to enhance the mechanical strength, zeolite particles loaded with silver ions are added to achieve antibacterial performance, epidermal growth factor release microspheres are added to promote healing, and the dressing can be further subjected to heparinization, plasma surface modification, thrombin addition, salt precipitation pore formation and sterilization treatment. The dressing prepared by the method has the functions of synergistic hemostasis, antibiosis and healing promotion, has good biocompatibility and suitable mechanical strength, and has a simple preparation process, and can be used for various wound care.

The utility model provides an infusion channel cap fixing device which comprises a fixing body. Wherein the fixing body comprises a main body piece and a fixing piece integrally formed on the main body piece; the main body piece is suitable for being detachably installed on the main body channel, the fixing piece is suitable for being detachably installed on the branch channel, and after the fixing piece is installed on the branch channel, the sealing cap can be fixed to the branch channel. When the infusion channel cap fixing device is used, the main body piece is installed on the main body channel of the heparin cap, the fixing piece is installed on the branch channel of the heparin cap, and the sealing cap on the branch channel makes contact with the inner wall of the top of the fixing piece. When the branch channel is used, the fixing body is detached firstly, and then the sealing cap is taken down from the branch channel. After the infusion channel cap fixing device is fixed on a heparin cap, a sealing cap can be fixed on a branch channel, so that the sealing cap can be prevented from being pressed or accidentally falling off.

The invention belongs to the technical field of medical materials, and particularly relates to an antibacterial and anticoagulant dual-function coating, a preparation method thereof and a needle head with the antibacterial and anticoagulant dual-function coating. S200, a PDPA coating is prepared; s300, grafting the heparin; s400, carrying out NO (nitric oxide) loading; the antibacterial and anticoagulant bifunctional coating prepared by the method has excellent antibacterial and anticoagulant functions, is used for hemodialysis, can effectively inhibit arteriovenous needle blockage and prevent bacterial infection, and is firm in adhesion and not easy to fall off.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

The present invention is directed to a homeopathic complex for use in the treatment of various diseases or disorders, including use as an anti-infective agent and / or in the regeneration of diseased or damaged tissue. Ideally, the anti-infective homeopathic complex of the invention may comprise a homeopathic tincture or dilutions thereof of Hepar sulphuris calcareum or other similar profiled Calcarea or Sulphur salt or acid, Lachesis muta or other remedy with a similar profile, Mercurius solubilis or similar mercury containing remedy and Silica or other silica containing compounds.