125 results about "Heparin" patented technology

The invention relates to the field of medical health and artificial intelligence, and discloses a cancer patient low-molecular heparin individualized dose dynamic optimization method based on reinforcement learning, and the method comprises the steps: S1, collecting multi-dimensional clinical data of a cancer patient, carrying out the preprocessing, carrying out the enhancement of the preprocessed data, and generating time sequence synthesis data; s2, based on the multi-dimensional clinical data and the time sequence synthesis data, constructing a reinforcement learning environment, including defining a state space, an action space and a reward function; s3, constructing an environment adaptive deep reinforcement learning EA-DRL model as a dose optimization model; performing model training and optimization in the reinforcement learning environment until convergence and obtaining an optimal dose decision strategy; and S4, inputting real-time dynamic clinical data of a patient to be decided into the trained dosage optimization model, and outputting individualized low molecular heparin LMWH administration dosage recommendation. Individualized precise administration is realized, and the treatment effect and the clinical medication safety are improved.

The invention belongs to the technical field of medical instruments, and provides a painless microneedle patch loaded with low-molecular-weight heparin and a preparation method of the painless microneedle patch in order to solve the problems that most existing microneedle products aim at small-molecular drugs, lack protection and slow release design for the low-molecular-weight heparin, low drug loading efficiency, poor activity retention and incapability of adapting to long-term anticoagulation treatment. The painless micro-needle patch comprises a substrate layer and a composite micro-needle, the composite microneedle is composed of a plurality of microneedles arranged in an array and fixed on one surface of the substrate layer and a low-molecular heparin delivery material loaded in the microneedles. According to the painless microneedle patch loaded with the low-molecular heparin, efficient percutaneous delivery of drugs can be achieved, local adverse reactions are reduced, the operation process is simplified, and the long-term drug use requirements under different anticoagulation scenes are met.

The application discloses a kind of consumable conveying devices, comprising: guide wire conveying unit, guide wire is contained in guide wire coil and passes between the pair of guide wire guide wheels, with the rotation of guide wire guide wheel, guide wire is driven forward or backward to retreat;And catheter / stent conveying unit, catheter / stent is contained in catheter / stent coil and passes between the pair of catheter / stent guide wheels, with the rotation of catheter / stent guide wheel, catheter / stent is driven forward or backward to retreat;Wherein the proximal end of guide wire coil is provided with guide wire wetting section, at guide wire wetting section, the upper end side wall of guide wire coil is provided with drop opening, heparin or physiological saline is dropped through drop opening, to wet guide wire in guide wire coil.The application conveys guide wire, catheter / stent and other medical instruments by conveying device, improves the efficiency of guide wire, catheter or stent into human body, reduces the pollution in the preoperative preparation process of guide wire, catheter or stent, and then simplifies the operation of doctor.

The invention provides a small-cavity surgical robot with an anti-blocking mechanism, and relates to the technical field of surgical robotics.The small-cavity surgical robot comprises a mechanical arm, an operation platform is rotationally installed on the mechanical arm, an operation instrument used for conducting an operation on a patient is arranged on the operation platform, and a fixing frame is fixedly installed on the operation platform; a circular space between the inner pipe and the outer pipe is divided into two independent areas, the two independent areas are matched with the two connecting pipelines on the outer pipe and the connected micro peristaltic pump, and therefore the inner pipe and the outer pipe can be separated into two independent areas. By means of the design, normal saline and a low-concentration heparin solution can be conveyed respectively, the washing requirement in a conventional operation is met, anticoagulation treatment can be provided for an operation scene with the high blood coagulation risk, the application range of the surgical robot is greatly widened, surgical operation is more targeted and flexible, and the surgical robot is suitable for being popularized and used. And individual differences of different patients can be effectively handled.

The application relates to the technical field of medical dressing preparation, and discloses a hemostatic, healing-promoting and antibacterial foam dressing and a preparation method thereof. The method uses sodium alginate and carboxymethyl chitosan as a composite polysaccharide matrix, mixes the two, adds a calcium chloride solution to crosslink a porous gel support, and then carries out freeze-drying to obtain a porous framework; gelatin and polyvinyl alcohol can be further added to enhance the mechanical strength, zeolite particles loaded with silver ions are added to achieve antibacterial performance, epidermal growth factor release microspheres are added to promote healing, and the dressing can be further subjected to heparinization, plasma surface modification, thrombin addition, salt precipitation pore formation and sterilization treatment. The dressing prepared by the method has the functions of synergistic hemostasis, antibiosis and healing promotion, has good biocompatibility and suitable mechanical strength, and has a simple preparation process, and can be used for various wound care.

The utility model provides an infusion channel cap fixing device which comprises a fixing body. Wherein the fixing body comprises a main body piece and a fixing piece integrally formed on the main body piece; the main body piece is suitable for being detachably installed on the main body channel, the fixing piece is suitable for being detachably installed on the branch channel, and after the fixing piece is installed on the branch channel, the sealing cap can be fixed to the branch channel. When the infusion channel cap fixing device is used, the main body piece is installed on the main body channel of the heparin cap, the fixing piece is installed on the branch channel of the heparin cap, and the sealing cap on the branch channel makes contact with the inner wall of the top of the fixing piece. When the branch channel is used, the fixing body is detached firstly, and then the sealing cap is taken down from the branch channel. After the infusion channel cap fixing device is fixed on a heparin cap, a sealing cap can be fixed on a branch channel, so that the sealing cap can be prevented from being pressed or accidentally falling off.

The invention provides an anti-coagulation coating. The anti-coagulation coating comprises an anti-coagulation component and a cross-linking agent, the preparation method of the anti-coagulation coating comprises the following steps: plasma activation: carrying out surface activation treatment on the surface of the conduit by adopting plasma; preparing a surface anti-coagulation coating: firstly preparing an anti-coagulation solution, immersing the catheter in the anti-coagulation solution containing phosphorylcholine, placing the catheter at room temperature after dip-coating, then placing the catheter in a curing box for curing, and taking out the catheter after the catheter is cooled to the room temperature, so as to prepare the catheter with the anti-coagulation coating containing phosphorylcholine; according to the anticoagulant coating, complications such as thrombus and fibrin sheath are reduced, the safety of a product is improved, anaphylactic reaction caused by drugs and heparin is avoided, and a passive anticoagulation mode is adopted, so that the blood coagulation capacity of a patient cannot be reduced, and the risk that a wound cannot be healed can be effectively reduced.

To provide a factor Xa reagent.SOLUTION: Exemplary compositions include Factor Xa, a substrate, one or more guanidine derivatives, and in some cases heparin. An exemplary method of detecting an anticoagulant in a sample includes combining or contacting a composition with a sample and measuring factor Xa activity based on substrate status. The composition modulates the activity of factor Xa in the sample, and the modulation includes a reduction in the rate of clotting of the sample caused by factor Xa. The presence of an anticoagulant is based on the activity of factor Xa.SELECTED DRAWING: None

The present invention relates to a method for preparing a multilayer heparin conjugate coating on a substrate, the method promoting good adhesion to the substrate surface and increasing the number of available heparin molecules.

The application relates to the technical field of indwelling needles, and discloses an indwining needle capable of preventing blood backflow, which comprises a venous tube, a filling pipeline fixedly connected to the top of the venous tube, a hose fixedly connected to the outside of the filling pipeline, a mixed liquid tube fixedly connected to one end of the hose, a transfusion tube fixedly connected to one end of the mixed liquid tube, a heparin cap fixedly connected to the other end of the mixed liquid tube, a drainage ball movably connected between the filling pipeline and the hose, and second anastomosis walls for anastomosing the drainage ball formed by the concave shapes of the two sides of the replacement ring, a drainage hole arranged on the drainage ball, the filling pipeline communicated with the hose through the drainage hole, and a three-labium sealing plate movably connected to the inside of the filling pipeline. The indwining needle capable of preventing blood backflow is characterized in that blood in the hose flows into the inside of the filling pipeline, and when the liquid level in the inside of the filling pipeline drops, the three-labium sealing plate slowly drops to re-contact the drainage ball, so that the channel between the filling pipeline and the hose is closed, thereby preventing the possibility of blood backflow in the pipeline.

This utility model belongs to the field of medical device technology, specifically relating to a double-lumen central venous catheter with anti-wall adhesion and anticoagulation functions, including an extension tube, a double-lumen catheter, and a connector; the extension tube is connected to the double-lumen catheter through the connector; the double-lumen catheter is divided into two inlet lumens by a diaphragm, and the two inlet lumens are connected to two corresponding extension tubes; a side hole and a main hole are provided at the end of the double-lumen catheter, and the end of the double-lumen catheter has a C-shaped segment, with the side hole located on the concave side of the C-shaped segment, and the main hole located at the end of the double-lumen catheter. The C-shaped segment in this design reduces the occurrence of the side hole adhering to the blood vessel wall, reducing the probability of local coagulation and thrombosis when used for pediatric hemodialysis blood drainage; the biomimetic sharkskin microgrooves etched on the outside of the double-lumen catheter reduce resistance to blood flow and thrombus formation; the biomimetic sharkskin microgrooves can be filled with covalently grafted sulfonated heparin-hydrogel, continuously releasing anticoagulant factors, further reducing the formation of wall-attached thrombi.

The application discloses a tumor department-preventing-skin-swelling-at-needle-inserting-site indwelling needle auxiliary device, and relates to the technical field of medical devices, which comprises a first support frame, a cover plate, a fixed plate, an elastic clamping block, a fixed block, an indwelling needle and a first inclined frame, etc., the upper side of the first support frame is rotationally connected with the cover plate, the front side of the bottom of the cover plate is fixedly connected with the fixed plate, the rear side of the bottom of the cover plate is slidingly connected with the elastic clamping block used for clamping a heparin cap, the rear side of the bottom of the cover plate is fixedly connected with the fixed block, the indwelling needle is arranged between the elastic clamping block and the fixed block, and the rear side of the fixed plate is slidingly connected with the first inclined frame. The heparin cap is inserted between the elastic clamping block and the fixed block, the first clamping plate and the fixed plate clamp the catheter, then the inner needle tube is pinched, the inner needle is inserted into the patient's hand, the clamping effect is realized, and the catheter and the inner needle are prevented from moving to cause the skin swelling at the needle-inserting site.

The invention provides a prefabricated negative pressure connecting device for a puncture needle, and relates to the technical field of puncture needle negative pressure connection, the prefabricated negative pressure connecting device comprises a negative pressure cavity, a negative pressure adjusting mechanism, a rapid separation mechanism, an anti-reflux mechanism, a sealing detection module, a negative pressure maintaining module, a puncture needle adaptation module and a control module; by arranging the negative pressure adjusting mechanism to be matched with the negative pressure maintaining module, a set negative pressure value can be established and stably maintained in advance, real-time suction in the puncture process is not needed, the operation process is remarkably simplified, and the work intensity of medical workers is reduced; the puncture needle connecting modules matched with multiple specifications are adopted, an elastic sealing structure is matched, puncture needles of different models can be compatible, rapid sealing connection is achieved, and the clinical applicability of the device is improved; the quick separation mechanism adopts a buckle type sealing design, the negative pressure cavity can be quickly separated by a single hand after successful puncture, meanwhile, the negative pressure state of a puncture needle tube cavity is automatically kept, and subsequent connection operation of pipelines such as heparin caps and the like is facilitated.

Provided are: a heparin extraction method enabling extraction of heparin from an organ while maintaining an edible state of the organ; an edible organ with a low heparin content and a method for producing the same; an organ treatment method; and an organ treatment system.　The present invention makes it possible to extract heparin from an organ while maintaining an edible state of the organ by subjecting the organ to an alkali treatment at a low temperature. The extracted heparin can be utilized as a medicine or the like, and the organ after the extraction can be utilized as food.

The present disclosure relates to an implantable vascular graft material, including: a substrate including a graft material, the substrate defining a top surface and a bottom surface; and one or more bispecific binding partners having a luminal binding domain bound to the top surface and one or more cellular binding domains. In embodiments, the disclosure includes an implantable vascular graft including: a tubular base layer including a graft material, the tubular base layer defining a luminal surface and an abluminal surface; and a fusion peptide having a heparin binding domain bound to the luminal surface and one or more monocyte binding domains. In embodiments, the present disclosure provides one or more implantable vascular grafts such as A-TEVs, methods of making vascular grafts, methods of use, and the like.

The utility model discloses a blunt trocar for a heparin cap, which relates to the field of medical instruments and comprises a trocar body, one end of the trocar body is provided with a needle opening with an oblique opening structure, the trocar body is provided with a protection structure, and the protection structure is at least provided with protection parts covering two opposite sides of the needle opening. According to the heparin cap puncture needle, the resistance during heparin cap puncture is reduced, the working intensity of medical staff is relieved, and meanwhile direct contact with a needle opening in the using process is avoided.

The invention relates to the field of blood coagulation detection, and provides a thrombelastogram heparin detection reagent and application thereof. The thrombelastogram heparin detection reagent provided by the invention comprises a substrate reagent and a heparinase reagent, the substrate reagent is an amino polysaccharide substance, and through combination of the two reagents, the heparinase reagent can be effectively fixed into a sample cup, adsorption of the inner wall of the sample cup to heparinase is reduced, the activity of the heparinase is protected, and meanwhile the heparinase reagent can be rapidly released during detection. The invention also provides an application of the thrombelastogram heparin detection reagent in preparation of a thrombelastogram heparinase cup.

The application discloses an endogenous polypeptide, a preparation method and application thereof. A structural formula of the polypeptide is shown in formula (I): R1-(AA1)m-AA2-AA3-(AA4)n-R2, formula (I); wherein m is independently 2 or 3; n is independently 1, 2 or 3; AA1 is independently K, R or H; AA2 is independently I or W; AA3 is independently I or W; AA4 is independently K, R or H; R1 is any one of -H, Y, LY, PLY or LLY; and R2 is any one of -OH, L, LL, E, EL, EW, W, EH or EHL. The polypeptide has removed a high-affinity heparin binding domain while retaining the targeted antioxidant and anti-inflammatory functions, thereby avoiding signal interference and potential biological safety risks possibly caused by full-length PF4, and meeting the safety requirements of cosmetic ingredients.

Embodiments herein include multilayer thromboresistant coatings and medical devices including the same. In various embodiments, the thromboresistant coating can include a medical device with an antithrombogenic coating comprising a substrate, a tie layer disposed over the substrate, a hydrophilic layer disposed over the tie layer, and a heparin layer disposed over the hydrophilic layer. The hydrophilic layer comprises a photo-PVP compound and the heparin layer comprises a photo-heparin. The tie layer, the hydrophilic layer, and the heparin layer are less than or equal to 100 nm thick in total. Other embodiments are also included herein.

The invention discloses a spraying device for a heparin lithium solution. The spraying device comprises a shell, the air pump body is fixedly connected to the middle of the inner top wall of the shell; the solution box is fixedly connected to two side walls in the shell and is used for storing a heparin lithium solution; one end of the conveying pipe is inserted into the solution box, and a first one-way valve is mounted at the other end; and the conveying cavity is fixedly connected to the inner wall of the circular groove in the middle of the top face of the shell, and a quantitative extraction mechanism is arranged in the conveying cavity. Through cooperation of the quantitative extraction mechanism, the conveying cavity and the solution box, accurate quantitative taking of a solution is achieved. Specifically, a medical worker can clamp a blood collection barrel into a specified clamping groove before blood collection, then the pressure of the conveying cavity is controlled to be relieved through a microcontroller, at the moment, a positioning spring drives a piston block to retract in the conveying cavity, and under the directional conduction effect of a first one-way valve, a conveying pipe accurately sucks a heparin lithium solution in a solution box into the conveying cavity; therefore, quantitative extraction and spraying of the solution are achieved.

The utility model discloses a hemodialysis filter with a blood perfusion adsorption function. The hemodialysis filter comprises a filter, two dialysate connectors, a plurality of hollow fiber filaments, two blood connectors and a plurality of adsorption particles. The two dialysate connectors are fixedly connected with the outer wall of the filter, the inner ends of the two dialysate connectors penetrate through the inner wall of the filter, and the dialysate connectors are used for conveying dialysate; the plurality of hollow fibers are mounted on the inner wall of the filter and are made of polyether sulfone membranes; the two blood interfaces are respectively connected in series with the two ends of the filter; the plurality of adsorption particles are mounted in the hollow fiber filaments which are far away from the blood connector and the dialysate connector and are 1 / 3-1 / 2 of the number of the hollow fiber filaments, and the adsorption particles are resin carbon soaked by heparin. According to the hemodialysis and perfusion combined device, the hemodialysis and perfusion functions can be simultaneously completed by a single device through the combination of the characteristics of the hemodialysis filter and the hemoperfusion device, so that the occurrence of infection of patients is reduced.

The utility model relates to the technical field of medical instruments, in particular to a heparin cap protection device which comprises a dialysis catheter infusion end, the right end of the dialysis catheter infusion end is connected with a heparin cap through threads, the outer side of the heparin cap is movably sleeved with a nylon opening sleeve, and the dialysis catheter infusion end is located in the nylon opening sleeve. The upper side and the lower side of the nylon opening sleeve are respectively provided with a power assisting plane, and the top of each power assisting plane is fixedly provided with an adjusting main strip. Through the cooperation of the circular ring locking strip, the positioning strip and other structures, the connection firmness of the heparin cap and the infusion end of the dialysis catheter is enhanced, operation is easy, convenient and rapid, a large number of medical resources and labor cost are saved, meanwhile, the fixing effect is remarkable, and efficiency is extremely high.

This invention discloses a multi-compartment disinfection and docking device for hemodialysis catheters, comprising a capsule; the capsule is provided with several connecting tubes for docking with a dialysis machine; the capsule contains a first disinfection compartment for disinfecting old heparin caps, a removal compartment for removing old heparin caps, a second disinfection compartment for disinfecting the indwelling catheter interface, and a docking compartment for docking with the connecting tubes; both the first and second disinfection compartments are equipped with sterilizers for disinfection. This invention integrates the nursing work during dialysis treatment from the original multi-step, scattered actions into a continuous operation within the capsule. Simply insert the indwelling catheter into the capsule and proceed sequentially through the first disinfection compartment, removal compartment, second disinfection compartment, and docking compartment. Disinfection, cap removal, re-disinfection, and docking can be completed within the capsule by rubbing it; this simplifies the operation, avoids bacterial infection and contact contamination, and ensures the convenience and safety of hemodialysis nursing work.

This invention provides a medication supply device that is not easily limited by the packaging materials of medications such as heparin and can use a single package of medication for multiple treatments. The medication supply device supplies medication to a blood circuit of a blood purification device for purifying blood. The medication supply device includes: a composition holding section capable of introducing an anticoagulant contained in a container from a container and holding a composition containing at least the introduced anticoagulant; and a connecting section connecting the composition holding section to the blood circuit, capable of exporting the composition from the composition holding section to the blood circuit.

The invention discloses a hemostatic stent for heart great vessel surgery, which belongs to the technical field of medical instruments and comprises a shell, an adjusting knob, a piston part, a limiting plate and an airtight plate. The piston piece can be driven to extrude gas by twisting the adjusting knob, so that the expansion ring on the shell quickly expands to extrude the inner wall of a blood vessel to realize hemostasis; a clamping row groove of a limiting plate is matched with a positioning edge block of the piston piece, reverse movement of the piston piece can be prevented, stable hemostasis is ensured, unlocking and resetting can be achieved by pressing a knob column, and repeated use is facilitated; when the expansion ring reaches the maximum expansion state, high pressure in the expansion cylinder pushes the elastic film to bend, so that the medicine blocking boss is separated from the medicine outlet hole, heparin in the end head is released, local blood coagulation is inhibited in a targeted mode, the medicine dosage is reduced, and the problems that blood vessel endothelium injury is easily caused, the ischemia risk is high, and continuous operation of an operator is needed due to hemostasis of existing artery forceps are solved.

This invention relates to the field of biomedical materials technology, providing a heparinized dual-growth factor recellularized adipose tissue decellularized scaffold material, its preparation method, and its applications. The preparation method includes: decellularizing adipose tissue to obtain adipose tissue decellularized scaffold; heparinizing the scaffold to obtain a heparinized adipose tissue decellularized scaffold; loading hepatocyte growth factor and vascular endothelial cell growth factor onto the scaffold to obtain a heparinized dual-growth factor adipose tissue decellularized scaffold; seeding induced pluripotent stem cell-derived hepatocytes onto the scaffold, and culturing to obtain a heparinized dual-growth factor recellularized adipose tissue decellularized scaffold (RAT). This invention uses rat inguinal adipose tissue to prepare RAT material, which is low-cost, readily available, has a simple preparation process, and is easy to scale up. The RAT material of this invention can achieve liver tissue damage repair and hepatocyte regeneration, providing a new treatment strategy for acute liver failure.

The present application relates to a kind of protein combination, kit and system for predicting secondary infection of hepatitis B related liver failure patient, including the use of protein combination in the preparation for predicting secondary infection of hepatitis B related liver failure patient, the combination includes lysozyme LYZ, calmodulin 1 CALM1, heparin cofactor II SERPIND1 and cutin DPT.It is directly reflected that the combination is biomarker "inflammation-coagulation imbalance" this core mechanism of liver disease secondary infection, with high specificity, and the combination is not interfered by liver disease background, more can truly reflect the potential reaction state of body to infection under liver disease background, to overcome the problem of "failure" and "false negative" of traditional index ";The combination can significantly change concentration when patient is admitted to hospital early, without clinical infection signs, to provide key time window for early preventive treatment.

The utility model discloses a dual-channel anti-acupuncture arterial blood sample collector, relates to the technical field of medical instruments, and solves the problems in the prior art that the risk of local infection is increased and the working efficiency is reduced as multiple times of puncture are required to extract a blood sample. Comprising a puncture needle tube and a double-channel blood guide valve, the double-channel blood guide valve is arranged at the rear end of the puncture needle tube and comprises a valve body and a rotary core, a first blood guide tube and a second blood guide tube are perpendicularly arranged in the valve body in a crossed mode, and the front end of the first blood guide tube and the front end of the second blood guide tube are both communicated with an inner cavity of the puncture needle tube. The rear ends respectively correspond to the first valve port and the second valve port; the first valve port and the second valve port are respectively connected with a sample storage device and a heparin cap; the rotary core is rotationally connected into the valve body, and a blood guide groove is formed in the rotary core. The puncture needle has the advantages that passages can be switched by rotating the rotary core, sample collection is achieved after one-time puncture, working efficiency is improved, and infection risks are reduced.

The application discloses a rhabdomyosarcoma organoid culture medium, a construction method and a culture method, and belongs to the technical field of organoid model construction. The culture medium comprises a basic culture medium, basic components, specific factor components and additive components; the specific factor components comprise the following components with terminal concentrations: 5-20 mu g / mL heparin, 50-200 ng / mL IGF1, 10-100 ng / mL HGF, 30-80 ng / mL FGF-2 and 20-90 mu M A 83-01. The application has the beneficial effects that the application proposes a culture medium for culturing rhabdomyosarcoma organoids, can efficiently transform the rhabdomyosarcoma tissues removed by surgery into rhabdomyosarcoma organoids, the construction success rate can be as high as 95% or more, and the rhabdomyosarcoma organoids obtained are consistent with the HE staining results of the original surgical tissues. The application intends to solve the above technical problems, establish a rapid and effective rhabdomyosarcoma construction scheme, provide help for personalized medication of patients, provide a new platform for disease research and drug research of patients, and has a good application prospect.