92 results about "Tissue ingrowth" patented technology

Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and / or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. In an exemplary embodiment, first and second cuts are made into the reticular layer of a skin sample to separate an improved acellular dermal matrix (ACDM) which forms a dermal tissue form useful as a graft. The dermal tissue form consists essentially of reticular dermis and has a first exposed surface formed by reticular dermis, an opposite second exposed surface formed by reticular dermis, and has substantially uniform density and uniform porosity between the first and second exposed surfaces, which allows and promotes rapid and efficient cellular ingrowth and tissue ingrowth substantially equally from either the first or second exposed surfaces upon implantation.

A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

The invention relates to the technical field of medical instruments, in particular to a multi-layer ultra-light hernia patch which comprises a large-mesh electrostatic spinning tissue ingrowth layer, a mesh woven base material layer and an anti-adhesion layer which are sequentially connected in a stacked mode. Wherein after the large-mesh electrostatic spinning tissue ingrowth layer is implanted into a human body, a cell microenvironment can be better simulated, cell adhesion, differentiation and migration are facilitated, uniform distribution of newborn cells in the fiber direction of an electrospinning membrane is promoted, granulation tissues uniformly ingrow in a defect part, and the electrospinning fiber membrane and the tissues are cooperatively repaired; secondly, the middle layer can provide supporting performance and mechanical performance of the patch in the early stage for the patch, the defects of the electrospinning fiber membrane in the supporting performance and the mechanical performance are overcome, the long-term implantation amount of the patch after later degradation is greatly reduced, and the foreign body sensation is obviously reduced; the anti-adhesion layer also adopts the electrostatic spinning technology, and the anti-adhesion effect is achieved by selecting materials and regulating and controlling the porosity, the aperture and the fiber diameter of the electrospun fiber membrane.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet (1002) disposed in a foldable sheet (1104) including one or more templates including at least one of a partial support template (1110a, 1110b) and a full support template (1120). The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Various systems, devices, components and methods are disclosed for controllably and selectively occluding, restricting, and / or diverting flow within a patient's vasculature. The flow restriction systems can include an implant having a flow restrictor and an implantable controller having an actuator for actuating the flow restrictor. The implants can be severable from their respective controller and actuator. The implants can include a dual frame configuration to prevent tissue ingrowth into at least one of the frames.

This document provides implantable intraluminal stent graft medical devices. In some embodiments, the stent graft devices provided herein are implantable in bodily conduits that have side branches, and the stent graft devices are operable to allow the flow of fluids between the conduit and the side branches. In some embodiments, the walls of the stent graft devices provided herein include compliant channels which allow for fluid communication between the interior and the exterior of the stent graft devices. In some embodiments, the compliant channels are configured to inhibit or reduce tissue ingrowth, tissue bridging, and / or endothelialization.

Medical devices and methods of using medical devices are disclosed herein. An example medical device includes a skeleton including an inner surface, an outer surface, a proximal region, a distal region, a lumen extending from the proximal region to the distal region, and a retention member extending radially away from the outer surface. The retaining member has a distally facing surface and a proximally facing surface. A membrane is disposed inside the lumen of the tubular skeleton, and the membrane is secured to the inner surface of the tubular skeleton at a first circumferential attachment region and a second circumferential attachment region. Further, the membrane is not attached to the inner surface of the tubular scaffold between the first circumferential attachment region and the second circumferential attachment region to define a tissue ingrowth region between the inner surface of the tubular scaffold and the outwardly facing surface of the membrane.

The present application relates to a kind of nasal ala base subperiosteal implant retention method, belong to plastic surgery medical instrument technical field.The present application provides a kind of nasal ala base subperiosteal implant soft tissue suspension retention method and its implant and system.The method includes: implant is placed into maxillary bone subperiosteal interstice, and implant fixed wing is fixed with the soft tissue anchor point such as alar base ligament of alar elevating lip muscle using drug-loaded degradable suture and is suspended and fixed.Implant surface is provided with the microporous structure of guiding tissue ingrowth, and is provided with the drug depot recess of filling load immunomodulator temperature-sensitive hydrogel.Postoperative healing process, suture is released under the action of tension to accelerate proangiogenic factor and promote local vascularization, and temperature-sensitive hydrogel slow-release immunomodulator induces macrophage to repair type polarization, and cooperatively promotes the biological chimeric fixation of implant and soft tissue.The present application can realize the double stable retention of implant, reduces postoperative displacement risk.

Devices, systems, and / or methods can provide compliance characteristics to fluid vessels. For example, an implant device can include an anchoring region to anchor the implant device to a blood vessel or other anatomy. The anchoring region can be disposed at one end of a flexible midsection that is configured to expand as a result of fluid flowing through the implant device. The flexible midsection can include another anchoring region at an opposite end. One or both anchoring regions are configured to encourage tissue ingrowth at an outer surface of the respective anchoring region.

Disclosed herein is an implantable prosthetic valve that is configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve. Methods of making such implantable prosthetic valves are also disclosed herein. Also disclosed herein are kits comprising one or more sutures configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve.

Disclosed herein are tissue regeneration materials and methods of production and use thereof. Particles with a controlled structure that improves the tissue regeneration process by providing more space for tissue ingrowth are disclosed.

An implantable article and methods of construction and use for the treatment of soft tissue defects that impact a patient's quality of life, such as a pelvic floor injury that results in urinary incontinence. The implantable article includes an implant assembly of a support member that can have anchoring zones, accelerated ingrowth zones, and support zones. The support assembly or its zones are constructed in various ways and with various materials to selectively control the location and rate of implant absorption and tissue ingrowth. The result is the formation of a tissue bridge or hybrid tissue bridge with reinforcing members.

In some embodiments, a dressing can include a treatment device configured with a central hub and a plurality of legs extending outwardly from the central hub. In some embodiments, the central hub and the legs can collectively constitute a treatment manifold configured to minimize tissue ingrowth. For example, the treatment manifold can include closed cell foam. In some embodiments, the treatment manifold can be unencapsulated. For example, a single film layer can be attached to a first surface of the treatment manifold, while an opposite surface of the manifold can be exposed and / or uncovered. Other devices, dressings, systems, and methods are also disclosed.

A balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a plurality of leaflets, an outer cuff configured to promote tissue ingrowth and an inner cuff having an inner surface and an outer surface, the inner surface of the inner cuff having a different ingrowth profile than the outer surface of the inner cuff.

Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth. In embodiments, the nonwoven pouches eliminate the use of knitted or woven multifilament fibers that can trap bacteria and result in post-operative infection.

In various embodiments, the ocular medicament delivery devices include multiple microporous layers arranged together to form a microporous body configured to meter dispensing of a medicament to surrounding tissues. In some embodiments, the ocular medicament delivery devices include one or more portions configured to resist tissue ingrowth, and one or more portions configured to permit tissue ingrowth. In some embodiments, the ocular medicament delivery devices deliver one or more medicaments useful in the treatment of glaucoma.

A barrier for use in negative pressure wound therapy can include a base layer and surface structures. The barrier can be used to reduce or prevent tissue ingrowth. A method of using a negative pressure wound therapy system can include positioning a perforated barrier in a wound. After positioning the perforated barrier in the wound, positioning a pad in the wound on top of the perforated barrier, positioning a seal on top of the wound to at least partially seal the perforated barrier and the foam in the wound, and applying negative pressure wound therapy to the wound.

The application discloses a kind of for hernia repair containing acellular dermis biological patch and preparation method thereof, belong to biomedical material field, raw material includes acellular porcine dermis layer matrix 90-110 parts, genipin 0.1-0.2 parts, EDC 0.8-2.5 parts, NHS 0.3-1 part, carboxymethyl chitosan 3-8 parts, sodium hyaluronate 1.5-4 parts, chondroitin sulfate 0.5-2 parts, glycerol 2-5 parts, modified zinc tannate nanocomposite 3-12 parts, effectively solve the problems that existing hernia repair patch anti-adhesion and tissue ingrowth is difficult to coordinate, support strength and degradation rate are not matched, foreign body exists in human tissue for a long time and leads to inflammation, by introducing anti-adhesion coating containing zinc tannate coordination nanocomposite and asymmetric double-sided structure, the patch realizes abdominal cavity side long-acting anti-adhesion, abdominal wall side rapid tissue integration and controllable degradation and mechanical support under low immunogenicity.

Fixation devices for implants and related methods are generally described. The fixation device may be wrapped around the implant prior to delivery to reduce the risk of implant migration after implantation. The device may have porosity to induce tissue ingrowth around the implant and improve surgical outcome. The device can be used for rapidly preparing implants and can adapt to implants of various sizes. In some embodiments, the device may include a central portion for covering an anterior surface of a breast implant and a peripheral portion for covering a posterior surface of the implant. The peripheral portion, which may include a continuous rim or a plurality of legs, may include a tab that secures the fixation device to an implantation site. In some embodiments, a tether may be coupled to a distal end portion of the peripheral portion, thereby serving as a pull cord that quickly wraps the device around the implant.

Implementations of palatal implants may include a core having a plurality of air jet textured core yarns, eight triaxial yarns coupled around the core and parallel to the core, wherein each of the eight triaxial yarns are air jet textured and have a plurality of looped filaments, 24 biaxial yarns braided around the core in a one over one under one pattern, a first weld offset from a first end of the palatal implant by 0.8 millimeters to 1.2 millimeters, and a second weld offset from a second end of the palatal implant by 0.8 millimeters to 1.2 millimeters. The looped filaments in the triaxial yarns may protrude through openings between the biaxial yarns, the palatal implant may have a total braid weight of 7,000 denier to 12,500 denier, and the palatal implant may be configured to stiffen a palate through tissue ingrowth into the palatal implant.

The invention relates to the technical field of surgical drainage, in particular to a drainage device and method used after general surgery department nursing operation, the drainage device comprises a drainage tube and a rack, a drainage boosting assembly is arranged on the inner wall of the drainage tube, and the drainage boosting assembly comprises a plurality of clamping grooves formed in the outer wall of the drainage tube at equal intervals; wave air bag ring assemblies are arranged on the inner sides of the multiple clamping grooves, each wave air bag ring assembly comprises a first annular air bag and an eleventh annular air bag which are sequentially arranged in the corresponding clamping groove in a sleeved mode, and air cavities are formed in the first annular air bags and the eleventh annular air bags, so that harmonious peristaltic waves can be generated for the drainage tube; the drainage effect of the drainage tube is improved, the hole distance of the side holes can be adjusted in real time according to the postoperative drainage condition, tissue ingrowth is effectively prevented, early soft blockage is relieved, the drainage environment is further disturbed, static attachment is prevented, and the overall drainage efficiency and quality of the device are guaranteed.

Implantable materials for use with end effectors like surgical stapling devices, and methods for using the same, are generally provided. In some embodiments, adjunct materials for use with surgical staplers are provided. For example, a kit for stapling tissue is provided that can include a surgical stapler having an end effector. The end effector can have first and second jaws. The kit can include an adjunct material having hydrophobic surface regions and hydrophilic surface regions and the adjunct material can be configured to mate to at least one of the jaws of the end effector. Other implants, devices, and methods for surgical stapling are also provided.

A drainage device for draining a biological fluid from an eye to a tissue outside the eye, the drainage device being at least partially implantable within the tissue of the eye. The drainage device includes a body portion including a membrane having a first surface and a second surface, the first surface having a first porosity and the second surface having a second porosity greater than the first porosity; and a plate having a porosity less than the first porosity. The film is softer than the plate, and the first thickness of the film is 25 [mu] m to 125 [mu] m. The second thickness of the plate is 0.8 mm to 2.0 mm. The membrane and the plate define a reservoir. A conduit fluidly coupled with the reservoir and insertable into the eye facilitates the introduction of fluid into the conduit. The second surface of the membrane includes one or more ingrowth surface regions that facilitate ingrowth of external tissue of the eye.

An orthopedic assembly includes a tibial prosthesis that includes a body that defines an anterior side and a posterior side. The body further incudes a recess in the anterior side of the joint prosthesis and a plurality of openings that extend through the body from the anterior side to the posterior side thereof. At least a first and second opening of the openings are positioned at respective lateral and medial sides of a longitudinal axis of the tibial prosthesis. A modular insert is positioned within the recess of the body such that at least a portion of the modular insert is positioned between the openings of the body. The modular insert is formed separately from the tibial prosthesis and has a porous outer surface to promote tissue ingrowth.

Dressings are provided herein having a manifold and a biopolymer layer. The configuration and / or compressibility of the manifold and the biopolymer layer can allow for reduced tissue ingrowth and promote wound healing. Methods of making and using the dressings are also provided herein.