29 results about "Tissue ingrowth" patented technology

The present application relates to a kind of nasal ala base subperiosteal implant retention method, belong to plastic surgery medical instrument technical field.The present application provides a kind of nasal ala base subperiosteal implant soft tissue suspension retention method and its implant and system.The method includes: implant is placed into maxillary bone subperiosteal interstice, and implant fixed wing is fixed with the soft tissue anchor point such as alar base ligament of alar elevating lip muscle using drug-loaded degradable suture and is suspended and fixed.Implant surface is provided with the microporous structure of guiding tissue ingrowth, and is provided with the drug depot recess of filling load immunomodulator temperature-sensitive hydrogel.Postoperative healing process, suture is released under the action of tension to accelerate proangiogenic factor and promote local vascularization, and temperature-sensitive hydrogel slow-release immunomodulator induces macrophage to repair type polarization, and cooperatively promotes the biological chimeric fixation of implant and soft tissue.The present application can realize the double stable retention of implant, reduces postoperative displacement risk.

Disclosed herein is an implantable prosthetic valve that is configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve. Methods of making such implantable prosthetic valves are also disclosed herein. Also disclosed herein are kits comprising one or more sutures configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve.

A balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a plurality of leaflets, an outer cuff configured to promote tissue ingrowth and an inner cuff having an inner surface and an outer surface, the inner surface of the inner cuff having a different ingrowth profile than the outer surface of the inner cuff.

The application discloses a kind of for hernia repair containing acellular dermis biological patch and preparation method thereof, belong to biomedical material field, raw material includes acellular porcine dermis layer matrix 90-110 parts, genipin 0.1-0.2 parts, EDC 0.8-2.5 parts, NHS 0.3-1 part, carboxymethyl chitosan 3-8 parts, sodium hyaluronate 1.5-4 parts, chondroitin sulfate 0.5-2 parts, glycerol 2-5 parts, modified zinc tannate nanocomposite 3-12 parts, effectively solve the problems that existing hernia repair patch anti-adhesion and tissue ingrowth is difficult to coordinate, support strength and degradation rate are not matched, foreign body exists in human tissue for a long time and leads to inflammation, by introducing anti-adhesion coating containing zinc tannate coordination nanocomposite and asymmetric double-sided structure, the patch realizes abdominal cavity side long-acting anti-adhesion, abdominal wall side rapid tissue integration and controllable degradation and mechanical support under low immunogenicity.

Fixation devices for implants and related methods are generally described. The fixation device may be wrapped around the implant prior to delivery to reduce the risk of implant migration after implantation. The device may have porosity to induce tissue ingrowth around the implant and improve surgical outcome. The device can be used for rapidly preparing implants and can adapt to implants of various sizes. In some embodiments, the device may include a central portion for covering an anterior surface of a breast implant and a peripheral portion for covering a posterior surface of the implant. The peripheral portion, which may include a continuous rim or a plurality of legs, may include a tab that secures the fixation device to an implantation site. In some embodiments, a tether may be coupled to a distal end portion of the peripheral portion, thereby serving as a pull cord that quickly wraps the device around the implant.

The invention relates to the technical field of surgical drainage, in particular to a drainage device and method used after general surgery department nursing operation, the drainage device comprises a drainage tube and a rack, a drainage boosting assembly is arranged on the inner wall of the drainage tube, and the drainage boosting assembly comprises a plurality of clamping grooves formed in the outer wall of the drainage tube at equal intervals; wave air bag ring assemblies are arranged on the inner sides of the multiple clamping grooves, each wave air bag ring assembly comprises a first annular air bag and an eleventh annular air bag which are sequentially arranged in the corresponding clamping groove in a sleeved mode, and air cavities are formed in the first annular air bags and the eleventh annular air bags, so that harmonious peristaltic waves can be generated for the drainage tube; the drainage effect of the drainage tube is improved, the hole distance of the side holes can be adjusted in real time according to the postoperative drainage condition, tissue ingrowth is effectively prevented, early soft blockage is relieved, the drainage environment is further disturbed, static attachment is prevented, and the overall drainage efficiency and quality of the device are guaranteed.

Dressings are provided herein having a manifold and a biopolymer layer. The configuration and / or compressibility of the manifold and the biopolymer layer can allow for reduced tissue ingrowth and promote wound healing. Methods of making and using the dressings are also provided herein.

A biliary stent includes an expandable stent body that is expandable from a pre-deployment collapsed configuration to a post-deployment expanded configuration and a spun coating that is disposed over at least part of the expandable stent body. The spun coating includes a plurality of fibers defining interstices therebetween. The spun coating is adapted to impact tissue ingrowth. The spun coating may be adapted to encourage tissue ingrowth. The spun coating may be adapted to discourage tissue ingrowth.

Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth. In embodiments, the nonwoven pouches eliminate the use of knitted or woven multifilament fibers that can trap bacteria and result in post-operative infection.

The invention provides a multilayer artificial skin flap containing a built-in nutritional blood vessel and a preparation method of the multilayer artificial skin flap, and belongs to the technical field of tissue engineering and regenerative medicine. The artificial skin flap is sequentially provided with a first decellularized meat pulp matrix layer, a nutritional blood vessel, a fabric layer and a second decellularized meat pulp matrix layer from top to bottom. The nutrition blood vessel can construct a nutrition delivery channel for surrounding tissues, and promote rapid proliferation of cells and formation of a new blood vessel network; the decellularized meat pulp matrix layer provides a bionic microenvironment and supports cell adhesion, migration and growth; the fabric layer plays a role in enhancing mechanical support and simultaneously endows the flap with good stitchability and tear resistance; in addition, the nutritional blood vessel and the fabric layer are both made of degradable filaments, the degradation period can be regulated and controlled according to needs, and space and mechanical support smooth transition is vacated for tissue growth. The artificial skin flap has excellent biocompatibility, controllable degradability, active vascularization ability and proper mechanical properties, and is suitable for full-thickness skin defect repair and soft tissue regeneration engineering.

This application provides a method for preparing decellularized pericardium, employing a combination of specific pretreatment, sterilization, defatting, decellularization, and freeze-drying processes. This method effectively removes antigenic substances from animal tissues while maximally preserving the integrity of bioactive components and structures in the material. Simultaneously, the preparation process effectively incorporates inorganic metal ions, polysaccharides, and drugs to prevent adhesions. The resulting decellularized pericardium possesses both natural rough and smooth surfaces. The smooth surface has a dense fibrous structure, effectively blocking the invasion of adhesion tissues without affecting tendon function. The rough surface allows tissue ingrowth, facilitating rapid vascularization and tendon repair. Furthermore, the decellularized pericardium is loaded with functional components, further promoting tendon healing and preventing adhesions.

An orthopedic assembly includes a tibial prosthesis that includes a body that defines an anterior side and a posterior side. The body further incudes a recess in the anterior side of the joint prosthesis and a plurality of openings that extend through the body from the anterior side to the posterior side thereof. At least a first and second opening of the openings are positioned at respective lateral and medial sides of a longitudinal axis of the tibial prosthesis. A modular insert is positioned within the recess of the body such that at least a portion of the modular insert is positioned between the openings of the body. The modular insert is formed separately from the tibial prosthesis and has a porous outer surface to promote tissue ingrowth.

A cardiac support device comprising an implant with a shell (21), wherein the cardiac support device is an active cardiac support device comprising at least one expandable unit (23), wherein the shell (21) has a structured surface (22) that promotes tissue ingrowth, wherein the structured surface is located on the outer, non-cardiac surface of the shell, and wherein the tissue-stiffened shell (21) forms a support for the at least one expandable unit (23).

A composite material is disclosed including a porous polymer substrate and a nanoporous metal present within the microporous polymer substrate. The nanoporous metal may have a hierarchical structure. The nanoporous metal may have a unimodal and right-skewed number-based nanopore size distribution. The porous polymer substrate may support tissue integration and / or tissue ingrowth in certain applications. The composite material may be used in electrochemical analyte biosensors and other applications.

An external end device has a casing, including a base, in which a distal opening is formed which receives a funnel-shaped septum having a tube trunk. Inside the tube trunk, the catheter is connected to the distal section of the fitting. A tubular coating has a proximal end adapted to be grafted onto the tube trunk and a distal end coaxially adhering to the catheter. A pair of bands of tissue-ingrowth material is fixed on the tubular coating, and an anchor ring, equipped with anchoring means, is sandwiched between the bands.

Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body (“ballstent” or “blockstent”) and a flexible, elongated delivery device (“delivery catheter”) and systems and methods of use for treating saccular vascular aneurysms and methods of use for occluding segments of blood vessels and other biological conduits.Expandable bodies comprising gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm or blood vessel, and expanded to conform to the shape of the aneurysm or segment of blood vessel or biological conduit are disclosed. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. The wall of the expandable bodies can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, or tissue ingrowth.

The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices that have been treated in select areas to increase the compressive modulus of the matrix in the selected area while maintaining the ability to support cell growth and tissue regeneration. In addition, the tissue products can include collagen-containing materials that support tissue ingrowth along with a framework of collagenous or polymeric materials such that the combination has a desired compressive or tensile modulus and / or strength while maintaining the ability to support cell growth and tissue regeneration.

A port is adapted to be implanted to a body with its top exposed to the environment. The port has a housing defining a chamber that has an opening at the top of the housing. An aperture having a lumen attached thereto is formed at the lower portion of the chamber. For infusion, an insert that has an internal passageway that connects a fluid inlet at its top surface and a bore at its sidewall is sealingly mated to the chamber. The bore sealingly aligns with the aperture. After infusion, the insert is removed, and a blank insert is fitted to the chamber. A band of tissue ingrowth media encircles the housing to form an aseptic barrier where the outer wall of the housing and the tissue of the body encircling the housing meet.

The present disclosure relates generally to stents, systems, and methods for gastrointestinal treatment. In some embodiments, a stent may include a tubular scaffold having a first end opposite a second end, wherein a lumen extends between the first and second ends. The tubular scaffold may include a flared section and a medial section extending from the flared section, wherein a first diameter of the flared section is greater than a second diameter of the medial section. The stent may further include a liner extending partially along a surface of the tubular scaffold, wherein the liner is spaced from an anchoring region of the flared section to promote tissue ingrowth with the flared section.

The application provides a surface modification vascular stent integrating development positioning and active anchoring, and relates to the technical field of vascular stents. The vascular stent comprises a main stent and a development anchoring integrated part. The development anchoring integrated part comprises a development ring, an anchoring part and a linkage stent. The linkage stent is connected between the main stent and the development ring and is made of a first memory alloy material. The development ring has a segmented ring structure, and a gap between the development ring forms a tissue ingrowth gap for inducing vascular intimal tissue ingrowth. The anchoring part comprises an anchoring protrusion, and the anchoring protrusion comprises a tissue ingrowth cavity and a tissue ingrowth hole which are in communication with each other. After the development ring is radially expanded, the anchoring protrusion forms a mechanical anchoring with a blood vessel wall, and allows vascular intimal tissue to grow into the tissue ingrowth cavity through the tissue ingrowth hole to form a deep biological anchoring. Thus, the problems of unclear postoperative development and long-term displacement risk of the current vascular stent are solved.

A coated surgical mesh, the coated surgical mesh comprising: a surgical mesh, the surgical mesh comprising a first surface and a second surface; and a tissue ingrowth-preventing coating applied to the second surface of the surgical mesh; wherein the tissue ingrowth-preventing coating penetrates a controllable amount part way through the surgical mesh.

The application discloses a urethral mid-segment suspension band with post-implantation tissue repair stage adaptation function and a preparation method thereof. The suspension band comprises a middle functional support area for being arranged below the urethral mid-segment, and the middle functional support area comprises a composite support base and an active composite gel layer arranged in the composite support base. The composite support base comprises a biostable load-bearing framework arranged continuously or quasi-continuously along the length direction and a degradable load-reducing component combined with the biostable load-bearing framework; and the active composite gel layer comprises a composite gel network and surface-modified MOF active particles dispersed in the composite gel network. The degradable load-reducing component forms a tissue ingrowth space after degradation, and the surface-modified MOF active particles are used for loading and releasing active substances for regulating inflammatory response or oxidative stress. The application further discloses a preparation method of the suspension band.

The invention discloses a facial implantation filling material and a preparation method thereof, and relates to the technical field of medical materials. The facial implantation filling material is composed of 3D fiber-based composite microspheres and a gel matrix. 3D fiber-based composite microspheres are deeply wound and interlocked in a gel matrix to present highly uniform dispersity, so that stress is more effectively transmitted, the mechanical strength of the material is improved, post-implantation deformation is favorably resisted, and a bionic composite structure constructed by the 3D fiber-based composite microspheres and the gel matrix has good biocompatibility in a manner of resisting degradation, maintaining the volume and promoting tissue ingrowth. Active tissue regeneration and replacement are realized, and the effectiveness and long-term effect of the filling effect are remarkably improved.

Provided herein are a scaffold having a surface hyperboloid structure and its fabrication method and application. The scaffold has internally disposed with pores where each of the pores connects with each other and any point on a surface of each of the pores has the hyperboloid structure. Since the surface of the scaffold is smooth and stress concentration is thereby avoided, the scaffold can withstand a greater external force in the case of the same porosity. Moreover, since the pores inside the scaffold connect with each other, the scaffold has a better permeability to fluid and is more conducive to tissue ingrowth. In addition, the scaffold has a large internal surface area, rendering it feasible to subsequent surface treatment, such as film coating, to be carried out on the internal surface of the scaffold.

A sternal implant for implant into a body is provided. The implant includes an outer frame forming a structurally rigid portion. The outer frame includes a plurality of openings configured to accommodate sutures for affixing the outer frame to the body. The implant includes a central structure connected within the outer frame. The central structure includes a in the form of a layer having a construction including multiple channels. The filling portion is configured to allow for fluid drainage and tissue ingrowth of tissue generated by the body.

Described herein are breast implant fixation devices for breast reconstruction and breast augmentation. The new envelopes are designed to avoid lateral displacement and bottoming out of the breast implant, reduce capsular contraction and implant extrusion, eliminate skin dimpling and rippling caused by the breast implant, and reduce or eliminate palpability. The envelopes are adapted to fold securely around the breast implant, limit relative movement between the envelope and the breast implant, and reduce bunching. Tissue ingrowth into the envelope limits movement of the envelope-breast implant assembly, and thereby limits movement of the breast implant.

A biliary stent includes an expandable stent body that is expandable from a pre-deployment collapsed configuration to a post-deployment expanded configuration and a spun coating that is disposed over at least part of the expandable stent body. The spun coating includes a plurality of fibers defining interstices therebetween. The spun coating is adapted to impact tissue ingrowth. The spun coating may be adapted to encourage tissue ingrowth. The spun coating may be adapted to discourage tissue ingrowth.

This invention discloses a fully absorbable PDO-P4HB binary composite gradient degradable hernia repair patch, comprising: a PDO support layer, a P4HB toughening layer, and multiple composite connection nodes and edge reinforcement rings composed of PDO-P4HB blend materials. This invention uses a fully absorbable and non-immunogenic PDO+P4HB composite material, which can be completely degraded into non-toxic products and excreted from the body through hydrolysis and enzymatic degradation postoperatively, reducing the risk of complications such as infection and adhesions. It is suitable for complex repair scenarios such as infected abdominal wall defects. Utilizing the inherent difference in degradation rates between the two materials, and through specific weaving structures and parameter design, a gradient degradation structure is constructed to achieve a dynamic adaptation process of "early high-strength support (PDO-dominated) – mid-term flexible transition (synergistic between the two) – late complete degradation (P4HB finishing)," meeting both the rigidity requirements of intraoperative operations and the mechanical and biological needs of each stage of tissue repair, balancing support stability and tissue ingrowth.

The present technology relates to interatrial shunting systems and methods. In some embodiments, the present technology includes a system for shunting blood between a left atrium and a right atrium of a patient. The system can include a shunting element having a lumen extending therethrough. The lumen is configured to fluidly couple the left atrium and the right atrium when the shunting element is implanted in the patient. The system can also include a sensor configured to be implanted in the patient and operably coupled to the shunting element. An actuation element is coupled to the sensor. The actuation element is configured to be selectively energized and transmit a desired motion to the sensor to reduce the likelihood of tissue ingrowth / overgrowth and adhesion on at least a portion of the sensor.