62 results about "Tissue ingrowth" patented technology

A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

This document provides implantable intraluminal stent graft medical devices. In some embodiments, the stent graft devices provided herein are implantable in bodily conduits that have side branches, and the stent graft devices are operable to allow the flow of fluids between the conduit and the side branches. In some embodiments, the walls of the stent graft devices provided herein include compliant channels which allow for fluid communication between the interior and the exterior of the stent graft devices. In some embodiments, the compliant channels are configured to inhibit or reduce tissue ingrowth, tissue bridging, and / or endothelialization.

Medical devices and methods of using medical devices are disclosed herein. An example medical device includes a skeleton including an inner surface, an outer surface, a proximal region, a distal region, a lumen extending from the proximal region to the distal region, and a retention member extending radially away from the outer surface. The retaining member has a distally facing surface and a proximally facing surface. A membrane is disposed inside the lumen of the tubular skeleton, and the membrane is secured to the inner surface of the tubular skeleton at a first circumferential attachment region and a second circumferential attachment region. Further, the membrane is not attached to the inner surface of the tubular scaffold between the first circumferential attachment region and the second circumferential attachment region to define a tissue ingrowth region between the inner surface of the tubular scaffold and the outwardly facing surface of the membrane.

The present application relates to a kind of nasal ala base subperiosteal implant retention method, belong to plastic surgery medical instrument technical field.The present application provides a kind of nasal ala base subperiosteal implant soft tissue suspension retention method and its implant and system.The method includes: implant is placed into maxillary bone subperiosteal interstice, and implant fixed wing is fixed with the soft tissue anchor point such as alar base ligament of alar elevating lip muscle using drug-loaded degradable suture and is suspended and fixed.Implant surface is provided with the microporous structure of guiding tissue ingrowth, and is provided with the drug depot recess of filling load immunomodulator temperature-sensitive hydrogel.Postoperative healing process, suture is released under the action of tension to accelerate proangiogenic factor and promote local vascularization, and temperature-sensitive hydrogel slow-release immunomodulator induces macrophage to repair type polarization, and cooperatively promotes the biological chimeric fixation of implant and soft tissue.The present application can realize the double stable retention of implant, reduces postoperative displacement risk.

Devices, systems, and / or methods can provide compliance characteristics to fluid vessels. For example, an implant device can include an anchoring region to anchor the implant device to a blood vessel or other anatomy. The anchoring region can be disposed at one end of a flexible midsection that is configured to expand as a result of fluid flowing through the implant device. The flexible midsection can include another anchoring region at an opposite end. One or both anchoring regions are configured to encourage tissue ingrowth at an outer surface of the respective anchoring region.

Disclosed herein is an implantable prosthetic valve that is configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve. Methods of making such implantable prosthetic valves are also disclosed herein. Also disclosed herein are kits comprising one or more sutures configured to substantially reduce vascular nebula formation and / or uncontrolled tissue ingrowth along the implantable prosthetic valve.

In some embodiments, a dressing can include a treatment device configured with a central hub and a plurality of legs extending outwardly from the central hub. In some embodiments, the central hub and the legs can collectively constitute a treatment manifold configured to minimize tissue ingrowth. For example, the treatment manifold can include closed cell foam. In some embodiments, the treatment manifold can be unencapsulated. For example, a single film layer can be attached to a first surface of the treatment manifold, while an opposite surface of the manifold can be exposed and / or uncovered. Other devices, dressings, systems, and methods are also disclosed.

A balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a plurality of leaflets, an outer cuff configured to promote tissue ingrowth and an inner cuff having an inner surface and an outer surface, the inner surface of the inner cuff having a different ingrowth profile than the outer surface of the inner cuff.

Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth. In embodiments, the nonwoven pouches eliminate the use of knitted or woven multifilament fibers that can trap bacteria and result in post-operative infection.

In various embodiments, the ocular medicament delivery devices include multiple microporous layers arranged together to form a microporous body configured to meter dispensing of a medicament to surrounding tissues. In some embodiments, the ocular medicament delivery devices include one or more portions configured to resist tissue ingrowth, and one or more portions configured to permit tissue ingrowth. In some embodiments, the ocular medicament delivery devices deliver one or more medicaments useful in the treatment of glaucoma.

The application discloses a kind of for hernia repair containing acellular dermis biological patch and preparation method thereof, belong to biomedical material field, raw material includes acellular porcine dermis layer matrix 90-110 parts, genipin 0.1-0.2 parts, EDC 0.8-2.5 parts, NHS 0.3-1 part, carboxymethyl chitosan 3-8 parts, sodium hyaluronate 1.5-4 parts, chondroitin sulfate 0.5-2 parts, glycerol 2-5 parts, modified zinc tannate nanocomposite 3-12 parts, effectively solve the problems that existing hernia repair patch anti-adhesion and tissue ingrowth is difficult to coordinate, support strength and degradation rate are not matched, foreign body exists in human tissue for a long time and leads to inflammation, by introducing anti-adhesion coating containing zinc tannate coordination nanocomposite and asymmetric double-sided structure, the patch realizes abdominal cavity side long-acting anti-adhesion, abdominal wall side rapid tissue integration and controllable degradation and mechanical support under low immunogenicity.

Fixation devices for implants and related methods are generally described. The fixation device may be wrapped around the implant prior to delivery to reduce the risk of implant migration after implantation. The device may have porosity to induce tissue ingrowth around the implant and improve surgical outcome. The device can be used for rapidly preparing implants and can adapt to implants of various sizes. In some embodiments, the device may include a central portion for covering an anterior surface of a breast implant and a peripheral portion for covering a posterior surface of the implant. The peripheral portion, which may include a continuous rim or a plurality of legs, may include a tab that secures the fixation device to an implantation site. In some embodiments, a tether may be coupled to a distal end portion of the peripheral portion, thereby serving as a pull cord that quickly wraps the device around the implant.

Implementations of palatal implants may include a core having a plurality of air jet textured core yarns, eight triaxial yarns coupled around the core and parallel to the core, wherein each of the eight triaxial yarns are air jet textured and have a plurality of looped filaments, 24 biaxial yarns braided around the core in a one over one under one pattern, a first weld offset from a first end of the palatal implant by 0.8 millimeters to 1.2 millimeters, and a second weld offset from a second end of the palatal implant by 0.8 millimeters to 1.2 millimeters. The looped filaments in the triaxial yarns may protrude through openings between the biaxial yarns, the palatal implant may have a total braid weight of 7,000 denier to 12,500 denier, and the palatal implant may be configured to stiffen a palate through tissue ingrowth into the palatal implant.

The invention relates to the technical field of surgical drainage, in particular to a drainage device and method used after general surgery department nursing operation, the drainage device comprises a drainage tube and a rack, a drainage boosting assembly is arranged on the inner wall of the drainage tube, and the drainage boosting assembly comprises a plurality of clamping grooves formed in the outer wall of the drainage tube at equal intervals; wave air bag ring assemblies are arranged on the inner sides of the multiple clamping grooves, each wave air bag ring assembly comprises a first annular air bag and an eleventh annular air bag which are sequentially arranged in the corresponding clamping groove in a sleeved mode, and air cavities are formed in the first annular air bags and the eleventh annular air bags, so that harmonious peristaltic waves can be generated for the drainage tube; the drainage effect of the drainage tube is improved, the hole distance of the side holes can be adjusted in real time according to the postoperative drainage condition, tissue ingrowth is effectively prevented, early soft blockage is relieved, the drainage environment is further disturbed, static attachment is prevented, and the overall drainage efficiency and quality of the device are guaranteed.

Implantable materials for use with end effectors like surgical stapling devices, and methods for using the same, are generally provided. In some embodiments, adjunct materials for use with surgical staplers are provided. For example, a kit for stapling tissue is provided that can include a surgical stapler having an end effector. The end effector can have first and second jaws. The kit can include an adjunct material having hydrophobic surface regions and hydrophilic surface regions and the adjunct material can be configured to mate to at least one of the jaws of the end effector. Other implants, devices, and methods for surgical stapling are also provided.

A drainage device for draining a biological fluid from an eye to a tissue outside the eye, the drainage device being at least partially implantable within the tissue of the eye. The drainage device includes a body portion including a membrane having a first surface and a second surface, the first surface having a first porosity and the second surface having a second porosity greater than the first porosity; and a plate having a porosity less than the first porosity. The film is softer than the plate, and the first thickness of the film is 25 [mu] m to 125 [mu] m. The second thickness of the plate is 0.8 mm to 2.0 mm. The membrane and the plate define a reservoir. A conduit fluidly coupled with the reservoir and insertable into the eye facilitates the introduction of fluid into the conduit. The second surface of the membrane includes one or more ingrowth surface regions that facilitate ingrowth of external tissue of the eye.

An orthopedic assembly includes a tibial prosthesis that includes a body that defines an anterior side and a posterior side. The body further incudes a recess in the anterior side of the joint prosthesis and a plurality of openings that extend through the body from the anterior side to the posterior side thereof. At least a first and second opening of the openings are positioned at respective lateral and medial sides of a longitudinal axis of the tibial prosthesis. A modular insert is positioned within the recess of the body such that at least a portion of the modular insert is positioned between the openings of the body. The modular insert is formed separately from the tibial prosthesis and has a porous outer surface to promote tissue ingrowth.

Dressings are provided herein having a manifold and a biopolymer layer. The configuration and / or compressibility of the manifold and the biopolymer layer can allow for reduced tissue ingrowth and promote wound healing. Methods of making and using the dressings are also provided herein.

A biliary stent includes an expandable stent body that is expandable from a pre-deployment collapsed configuration to a post-deployment expanded configuration and a spun coating that is disposed over at least part of the expandable stent body. The spun coating includes a plurality of fibers defining interstices therebetween. The spun coating is adapted to impact tissue ingrowth. The spun coating may be adapted to encourage tissue ingrowth. The spun coating may be adapted to discourage tissue ingrowth.

Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth. In embodiments, the nonwoven pouches eliminate the use of knitted or woven multifilament fibers that can trap bacteria and result in post-operative infection.

The invention provides a multilayer artificial skin flap containing a built-in nutritional blood vessel and a preparation method of the multilayer artificial skin flap, and belongs to the technical field of tissue engineering and regenerative medicine. The artificial skin flap is sequentially provided with a first decellularized meat pulp matrix layer, a nutritional blood vessel, a fabric layer and a second decellularized meat pulp matrix layer from top to bottom. The nutrition blood vessel can construct a nutrition delivery channel for surrounding tissues, and promote rapid proliferation of cells and formation of a new blood vessel network; the decellularized meat pulp matrix layer provides a bionic microenvironment and supports cell adhesion, migration and growth; the fabric layer plays a role in enhancing mechanical support and simultaneously endows the flap with good stitchability and tear resistance; in addition, the nutritional blood vessel and the fabric layer are both made of degradable filaments, the degradation period can be regulated and controlled according to needs, and space and mechanical support smooth transition is vacated for tissue growth. The artificial skin flap has excellent biocompatibility, controllable degradability, active vascularization ability and proper mechanical properties, and is suitable for full-thickness skin defect repair and soft tissue regeneration engineering.

An implantable prosthesis for repairing tissue defects includes a layer of repair fabric and a plurality of microtextured grip segments mounted to the repair fabric. The grip segments include a pattern of perforations on a tissue facing surface to promote tissue ingrowth.

A self-expanding stent configured to shift between a delivery configuration and a deployed configuration, the self-expanding stent including a tubular body having a proximal end and a distal end. In embodiments, the tubular body of the self-expanding stent defines a proximal flange, a distal flange, and a saddle portion extending from the proximal flange to the distal flange. The proximal flange and / or the distal flange may include an open-cell foam material affixed adjacent to or within the proximal flange and / or the distal flange to promote tissue ingrowth therein. Additional flanges, flange orientations, materials, and disposition of materials for a self-expanding stent are also contemplated.

An apparatus for filling a wound can include an array of at least four truncated ellipsoids interconnected to define at least one fluid path through, for example perpendicular to, the array. The longest principal axis of each ellipsoid may be perpendicular to the array. Each truncated ellipsoid may be a spheroid and / or may include an approximately elliptical contact surface at each contact surface between two interconnected ellipsoids. Each fluid pathway may have four continuously-curved concave sides and may have a parallelogram-shaped cross-section with continuously-curved concave edges. A dressing may include the apparatus, a dressing layer coupled to the apparatus, a backing layer disposed over a surface of the dressing layer opposite the apparatus, and an attachment device disposed on at least a margin of the backing layer. Methods of treating various tissue sites using the apparatus or dressing with negative-pressure therapy are also disclosed.

Self-expanding, tubular (tapered or constant diameter), oval or elliptical (not circular) airway stents suitable for placement under open or minimally invasive approaches within patients of various sizes and of various species, and methods for their placement in a tracheobronchial tree of a patient. The airway stent may be provided in various lengths and have an oval or elliptical cross-sectional shape that is either constant or variable in both short axis dimensions. The airway stents are particularly suited for treating patients with large airway obstructions in whom the natural airway cross-sectional dimensions are oval or elliptical rather than circular. The airway stent allows for more anatomic filling of the natural airway lumen, reduces the need to oversize the airway stent diameter and therefore reduces subsequent stent fatigue and fracture, and improves stent-tracheal wall contact to minimize gaps that lead to mucus trapping and chronic infections with subsequent tissue ingrowth and airway obstruction.

Blood flow affecting implant and implantation thereof in superior vena cava, optionally including disintegration of endothelium layer and inducing tissue ingrowth within implant. Implant includes elongated body with optional tubular inner layer forming orifice, shapeable to final orifice diameter for restricting blood flowing therethrough to chosen average flow rate; and / or tubular outer layer provided coaxially around inner layer. Outer layer is formed of second material provided in elastically deformable state for facilitating elastic radial self-expanding from collapsed diameter up to relaxed maximal expanded diameter greater than diameter of inner wall portion of superior vena cava. Inner layer is formed of first material, in plastically or elastically deformable state.

The present application relates to the field of medical devices and discloses a ureteral stent and a preparation method thereof. The ureteral stent comprises a stent body and a nanofiber membrane. The stent body is woven into a 90-140ppi tube by spinning component A and component B in a mass ratio of 4:(1-2). The spun yarn obtained by component B is melted by heating and then combined with the spun yarn obtained by component A. The stent body is obtained after cooling. The nanofiber membrane components include polyethylene glycol and polyglycolide, as well as fucoidan-modified chitosan. A lubricant is sprayed on one side of the nanofiber membrane away from the stent body, and the membrane is wound around the outer surface of the stent body by electrostatic adsorption. The ureteral stent increases the stability and stiffness of the tube wall, improves the mechanical strength and durability, and the material is biocompatible and biodegradable, and can reduce irritation and damage to the urothelium, and prevent urothelial tissue ingrowth and adhesion.