42 results about "Mitral valve" patented technology

Apparatuses, systems, and methods for various devices, such as prosthetic valves. Some examples are directed to improvements in anchoring at a native heart valve, which may reduce possible trauma to a treatment or implantation site. Compliant and flexible anchoring features and methods are disclosed to reduce force upon a treatment or implantation site including heart tissue that surrounds leaflets of a mitral or tricuspid valve. Improved mechanisms for deployment of devices including motorized methods are also disclosed.

Modular prosthetic valves are disclosed that may support a customized number of leaflets. e.g., four or more leaflets carried by a support structure, such as a frame or stent, which may be used to replace diseased mitral, aortic, tricuspid, or pulmonary valves.

Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

Apparatuses, systems, and methods for prosthetic valves having sensor systems are disclosed. Examples of prosthetic valves include replacement heart valves for replacing the function of a native heart valve, such as a mitral or tricuspid valve. In various embodiments, replacement heart valves are provided with sensors or markers for assisting with proper placement and / or securement in the body. A replacement heart valve may include anchors for securing the replacement heart valve to native leaflets, wherein sensors and / or markers provide feedback to the physician for confirming proper placement of the anchors during the implantation procedure. Sensors may also be used to assess the function of the prosthetic valve after deployment. Sensors may also be used to monitor blood pressure, temperature, oxygen, insulin, cholesterol, and / or glucose to assess overall patient health.

The invention discloses a closing device for mitral valve leaflet repair, and relates to the technical field of mitral valve leaflet repair. The clamp comprises an upper jaw assembly, one side of the upper jaw assembly is arranged to be in an opening shape, the inner wall of the opening is slidably connected with a positioning clamp assembly, the end of the positioning clamp assembly is provided with an outer protruding part, and the top of the upper surface of the outer protruding part is provided with a hook-shaped groove. According to the invention, the closing assembly continuously abuts against and approaches to finally realize connection between the port and the clamping arms, so that the closing assembly and the two clamping arms form an integrally formed structure, the closing assembly is connected with the bottom of the mitral valve, the first clamping arm and the second clamping arm are connected with the top of the mitral valve, and the mitral valve is tightly closed in a cardiac contraction period; blood of the left ventricle is prevented from flowing back to the left atrium, so that it is ensured that the blood can be pumped into the aorta from the left ventricle in the correct direction, the closing assembly can be closed without depending on external force, and compared with the prior art, an external operation structure used for controlling turning is omitted.

The health-preserving conditioning tea is prepared from the following raw materials in parts by weight: 3 to 8g of earthworms, 2 to 9g of flos carthami, 4 to 7g of ground beetles, 5 to 10g of leeches, 1.5 to 6g of radix aucklandiae, 3 to 8g of herba verbenae, 2 to 5g of gadflies, 3 to 7g of arisaema cum bile, 6 to 10g of radix salviae miltiorrhizae, 4 to 8g of radix paeoniae rubra, 2 to 6g of bombyx batryticatus, 1.5 to 5g of scorpions and 4 to 9g of folium ginkgo. The conditioning tea has the beneficial effects that the conditioning tea not only can replace traditional western medicines and avoid drug resistance and side effects, but also is convenient to carry and take after being bagged, can relieve and reduce the symptoms of cardiovascular and cerebrovascular plaques, namely blockage, during long-term taking according to the treatment course, can prevent cardiovascular and cerebrovascular diseases, activate blood and promote menstruation, and can be used for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition has the effects of tonifying qi, preserving health, reducing blood fat and blood pressure, and also can be used for treating diseases such as chest distress, chest pain, cardiac hypertrophy, mitral valve and tricuspid valve regurgitation, myocardial ischemia and the like.

This invention discloses a mitral valve annuloplasty ring locking structure, comprising an annuloplasty ring body, including at least two metal strips, end metal tubes sleeved at the ends of the metal strips, and a connecting metal tube sleeved between two adjacent metal strips; the two end metal tubes are connected by a snap-fit ​​assembly so that the annuloplasty ring body is joined end to end to form a ring structure; one end of each of the two adjacent metal strips is inserted into the inner cavity of the connecting metal tube; the inner walls of the metal strips and the connecting metal tube are connected by the mitral valve annuloplasty locking structure. By providing at least two metal strips, end metal tubes sleeved at the ends of the metal strips, and a connecting metal tube sleeved between two adjacent metal strips, with the ends of the two adjacent metal strips furthest from the end metal tubes inserted into the inner cavity of the connecting metal tube, the size of the annuloplasty ring body can be adjusted by adjusting the length of the metal strips inserted into the connecting metal tube, thereby achieving the function of individually shrinking the annuloplasty ring body.

Prosthetic valves are provided, e.g., for replacing a mitral or aortic valve of a patient, that includes an annular valve body including an inlet end, an outlet end, and one or more valve members for selectively opening and closing a passage between the inlet and outlet ends, a sewing cuff attached around an outer perimeter of the valve body, and a flexible skirt removably attached around the outer perimeter adjacent the sewing cuff. The prosthetic valve may be introduced into a patient's body, positioned adjacent a valve annulus, and the sewing cuff may be secured around a perimeter of the valve annulus. The skirt may be secured to tissue adjacent the valve annulus to further seal the prosthetic valve around the valve annulus, or the skirt may be removed from the valve body, e.g., if the annulus is sufficiently sealed by the sewing cuff.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.

The invention discloses two special valves for surgical mitral valves and tricuspid valves after decay, which belong to the technical field of medical instruments and comprise a middle cylindrical section, two ends of the middle cylindrical section are respectively connected with an upper-end horn mouth and a lower-end horn mouth, and transition sections with smooth inner walls are formed between the horn mouths at two ends and the middle cylindrical section through gradually changing diameters. The edge of the upper-end horn mouth and the edge of the lower-end horn mouth are each formed by arranging a plurality of rhombus units in the circumferential direction, a plurality of contact points are arranged on the upper-end horn mouth, the contact points are distributed in a high-low alternating mode in the circumferential direction, each contact point is located between every two adjacent rhombus units, and the device is simple in structure, capable of being recycled and repositioned and small in minimally invasive implantation trauma.

To provide a deployment tool intended to facilitate implantation of an implant, such as a prosthetic device (e.g., a prosthetic valve), at one of the native mitral, aortic, tricuspid, or pulmonary valve regions of a human heart.SOLUTION: The delivery catheter, in various embodiments, is configured to deliver the anchoring device to an annulus of a native valve of a patient's heart, where the anchoring device can better secure the prosthesis to the native valve annulus. The sheath catheter may be utilized to deliver the delivery catheter and the catheter for deploying the prosthetic valve to the anchor device.SELECTED DRAWING: Figure 27

Disclosed herein are embodiments relating to methods for performing a minimally invasive procedure comprising delivering a linear annuloplasty ring using a delivery system. In some embodiments, the annuloplasty ring can be delivered using a transseptal or transapical approach. In some embodiments, the delivery system can position the annuloplasty ring using a flexible stabilizing mechanism and / or activate one or more anchors to extend outwardly from the annuloplasty ring.

A prosthesis secures a replacement valve in a heart. The prosthesis includes a radially expandable inflow section and outflow section, and migration blocker rods. The inflow section has a tapered shape and is implanted within an atrium of a heart adjacent a native valve annulus. The outflow section couples to the inflow section, and is configured to be implanted through the native valve annulus and at least partially within a ventricle of the heart. The migration blocker rods extend circumferentially around at least a portion of the outflow section and hold native leaflets of the heart valve. In a contracted configuration, the prosthesis may be implanted through a catheter into the heart. In an expanded configuration, the tapered shape of the inflow section in the atrium cooperates with the migration blockers in the ventricle to hold the prosthesis against the native valve annulus.

Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

The invention relates to the technical field of medical instruments, in particular to a special cardiac surgery head frame with a multi-body-position fixing structure, which comprises a mounting frame, a rotating rod is rotatably connected to the inner wall of the mounting frame, two round tubes are rotatably connected to the outer wall of the rotating rod, and a first fixing block and a second fixing block are fixedly connected to the outer walls of the round tubes respectively. Electromagnets are fixedly connected to the positions, corresponding to the first fixing block and the second fixing block, of the inner wall of the mounting frame, and through magnetic attraction control and arc-shaped limiting block design, switching of three modes of synchronous rotation of the head and the body, independent rotation of the head and independent rotation of the body is achieved; when the head is placed, a conical linkage structure is triggered by means of gravity, a supplementary air bag is extruded to supply air to a fixed air bag, placing, namely clamping and air bag attaching to the head are achieved, the risk of pressure sores is reduced, a fourth spring can drive the air bag to automatically return air and reset, manual operation is not needed, and operation is convenient. And the operation interference during the operation is reduced.

The present disclosure discloses a prosthetic valve annulus assembly comprising: an outer tube comprising an internal lumen and a plurality of windows; and a plurality of anchors positioned inside the outer tube and around a perimeter of the outer tube, where the plurality of anchors are configured to be ejected from a plurality of windows to anchor the prosthetic valve annulus assembly to annulus tissue of a patient, characterized in that the plurality of anchors are configured to be ejected in different directions, and wherein a first portion of the plurality of anchors is configured to be ejected to the ventricular side of the annulus tissue and a second portion of the plurality of anchors is configured to be ejected to the atrial side of the annulus tissue.

Implantable prosthetic device (100) that helps to seal native heart valves and prevent or reduce regurgitation through them, the prosthetic device (100) comprising: a coaptation element (110); several paddles (120, 122) that are movable between a closed position and an open position to accommodate native mitral or tricuspid valve leaflets (42, 44) between the paddles (120, 122) and the coaptation element (110); and a double-ended prong clamp (3000) having a base (3010) with joint sections (3020) located near the coaptation element (110) and movable arms (3030) extending from both ends of the base (3010); wherein each of the movable arms (3030) can be moved from an open position to a closed position in order to press the native mitral or tricuspid valve tissue (42, 44) against one of the several paddles (120, 122) respectively.

Systems and methods to obtain high-quality apical 4-chamber-long-axis (A4CLAX) views of the mouse heart. The pathological progression of heart function following transverse aortic constriction (TAC) surgery is monitored using both a long-axis biplane (LAX-BP) and the conventional PSAX-M mode assays. A clear visualization of both mitral and tricuspid valve leaflets in A4CLAX view images enabled detecting dysfunctions such as valve regurgitation and desynchronized opening due lower chamber contractile desynchronies. Additionally, A4CLAX echocardiography facilitated the characterization of right ventricle (RV) dysfunction in mice, including RV dilation, higher diastolic filling pressures, and early characterization of decreased RV free wall longitudinal strain caused by pulmonary hypertension secondary to TAC procedure. Furthermore, A4CLAX imaging expands upon our capabilities to study left atrial and appendage function. The A4CLAX methodology allows significantly more clinically comparable echocardiographic analyses in murine heart, including a LAX-BP assay that provides CMR-comparable accuracy to evaluate the LV volumes.

The utility model discloses a transcatheter mitral valve repair simulation simulator, which comprises a liquid storage tank, an installation port is arranged on the side wall of the liquid storage tank, the installation port is provided with a cable gland, and the cable gland is used for penetrating through a surgical instrument and realizing dynamic sealing with the surgical instrument; the model assembly is arranged in the liquid storage tank, the model assembly is used for simulating a human heart structure, and the model assembly comprises a heart simulation body and a lower cavity approach tube which are connected with each other; the heart simulation body comprises a simulation main body, an atrial septum simulation part arranged on the simulation main body and a left atrium arranged on the first side of the atrial septum simulation part, the atrial septum simulation part is configured to be punctured by a surgical instrument, the left atrium is provided with a left atrioventricular opening, and the left atrioventricular opening is provided with a mitral valve simulation part. The first end of the lower cavity inlet pipe is communicated with the space of the second side of the atrial septum simulation part, and the second end of the lower cavity inlet pipe corresponds to the cable gland in position.

The present invention relates to an artificial valve anchoring device and assembly, and a transcatheter heart valve replacement system. During transcatheter heart valve replacement, a capture ring and the artificial valve anchoring device are first implanted sequentially. An inflow end of the artificial valve anchoring device is provided with a skirt portion, which can address the problems of perivalvular leakage and regurgitation even before the artificial valve is released. The artificial valve anchoring device is also provided with two connecting arms, which are capable of penetrating gaps at the commissures of native valve leaflets and connecting to the capture ring, without affecting the function or movement of the native valve leaflets. A main body part of the artificial valve anchoring device can cooperate with the capture ring to simplify the patient's complex mitral / tricuspid valve structure into a standardized circular channel, providing a stable anchoring pathway for the artificial valve. The main body part and the artificial valve are connected by means of an interference fit. During subsequent implantation of the artificial valve, the release height of the artificial valve can also be adjusted according to the patient's actual situation.

The present invention relates to the field of minimally invasive surgical and interventional cardiology devices for cardiac valve repair. In particular, it relates to an instrument for minimally invasive repair of atrioventricular cardiac valves, mitral cardiac valves, and tricuspid cardiac valves, as well as a corresponding method. In particular, the instrument includes a first tube having a tube axis defining an axis; a leaflet grasping structure disposed in the distal portion of the first tube and adjacent to the first tube, the leaflet grasping structure including a body and jaws that are movable relative to the body; wherein the jaws include a first abutment surface facing proximally, and the body includes a second abutment surface facing distally; the instrument further includes a needle, wherein the needle is hollowed out and forms an inner tube, and wherein the needle is releasable from the first tube and axially movable relative to the body, whereby the leaflet grasping structure is capable of clamping the leaflets of the cardiac valve between the first and second abutment surfaces; and wherein the jaws are formed to allow the needle to extend through the jaws when the leaflets are clamped.

To effectively anchor or retain a valve at a mitral position.SOLUTION: Anchoring or docking devices 100 are configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, e.g., to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to securely attach the cover layers to cores of the docking devices.SELECTED DRAWING: Figure 10

Disclosed herein are improved supporting structures for heart valve prostheses that are collapsible to a low profile for delivery to the implantation site at the native heart valve. For example, the improved heart valve prostheses may be collapsed for minimally invasive delivery and then deployed / expanded at the native heart valve (e.g., mitral, aortic) for implantation. Advantageously, the collapsed configuration permits delivery through a small incision in the patient and also inhibits suture entrapment of the valve posts during implantation. The supporting structure includes an annular portion and a plurality of post members arranged along the annular portion that are collapsible for delivery and expandable for implantation. Also provided herein are delivery components that allow for delivery of the prosthesis.

A prosthetic heart valve includes three prosthetic valve leaflets coupled together at three commissure regions to form a central flow path. A collapsible and expandable valve frame for supporting the prosthetic valve leaflets is provided. The valve frame includes three cantilevered support arms for supporting the three commissure regions, and gaps are provided between the three cantilevered support arms for improving leaflet engagement and reducing thrombosis. The valve frame is positioned within an outer sealing frame, and the sealing frame is anchored to surrounding heart tissue. The prosthetic heart valve is adapted to be delivered using minimally invasive transcatheter surgery. The prosthetic heart valve is preferably used to replace a native mitral or tricuspid valve.

Devices, systems, and methods are disclosed for in vivo monitoring of flow of biological fluid in anatomy, such as blood flow through a heart valve (e.g., a mitral valve, a tricuspid valve, and / or an aortic valve) or a ventricle, as well as acoustic signals emanating from an internal bodily structure. The disclosed devices, systems, and methods enable continuous and autonomous measurement and assessment of cardiovascular and pulmonary function or dysfunction, and / or compilation with other monitoring data that can be used to measure or predict secondary factors.

The present invention discloses a mitral valve shaping ring, comprising: a contraction line, which has a shape memory function and is annular in a free state; a shaping ring body, which comprises a plurality of contraction sections which are sequentially sleeved on the outer periphery of the contraction line and are of a soft structure, wherein the plurality of contraction sections can be connected end to end to form an annular structure, and a contraction interval is provided between two adjacent contraction sections. Under the action of the contraction line, the shaping ring body drives the plurality of contraction sections to be connected end to end to form an annular structure. Since the contraction sections are of a soft structure, they can conform to the physiological activities of the mitral valve ring and can achieve coordinated movement with the cardiac cycle. Since the contraction line is a rigid structure and has a memory function, the contraction line can provide a supporting force for the shaping ring body to maintain the annular state, thus meeting the required supporting force requirements. Moreover, when the shaping ring body is loaded into the loading chamber of the conveying system, it can be in a straight line shape, and compared with the shaping ring body of a folding structure, it also has the advantage of a smaller conveying diameter.

The present disclosure relates to a transcatheter surgery system and methods for performing mitral valve annuloplasty and other surgical procedures. In an aspect, the transcatheter system includes a driving catheter configured to drive one or more anchors into tissue, a cinching catheter configured to cinch a wire extending through the one or more anchors, and a cutting catheter configured to cut a portion of the wire. The present disclosure also relates to an implant kit including a helical anchor defining an anchor passageway extending therethrough, a beaded wire defining longitudinally spaced apart beads, a stopper, the stopper being larger than the central passageway so as to be prevented from passing therethrough, and a cinching element larger than the central passageway so as to be prevented from passing therethrough, the cinching element defining a one-way gap allowing passage of the wire therethrough in only one direction.

Devices, systems, and methods for a prosthetic valve having a sensor system are disclosed. Examples of prosthetic valves include replacement heart valves for replacing the function of native heart valves, such as mitral or tricuspid valves. In various embodiments, a replacement heart valve is provided with sensors or indicia for facilitating proper placement and / or fixation within the body. A replacement heart valve may include an anchor for securing the replacement heart valve to a native leaflet, with sensors and / or indicia providing feedback to a physician for confirming proper placement of the anchor during an implant procedure. Sensors may also be used to assess the functionality of the prosthetic valve after deployment. Sensors may also be used to monitor blood pressure, temperature, oxygen, insulin, cholesterol, and / or glucose in order to assess the patient's overall health.

The present application relates to a kind of real-time wear test device for cardiovascular implant bicuspid valve / tricuspid valve, including multiple test mechanisms, test mechanism includes first compliance adjustment module, second compliance adjustment module, liquid flow pipeline and drive module, second compliance adjustment module is connected with valve carrier module and reflux pipe between first compliance adjustment module;Liquid flow pipeline one end is communicated with first compliance adjustment module, the other end is connected with drive module;Test liquid sequentially flows through liquid flow pipeline, first compliance adjustment module, reflux pipe, second compliance adjustment module and valve carrier module, and reflux to first compliance adjustment module and liquid flow pipeline, to carry out cyclic reciprocating motion.The present application can simulate the test environment of highly approximate human physiological condition, to ensure the reliability and accuracy of bicuspid valve and tricuspid valve test result, provide real and reliable basis for evaluating the service life of bicuspid valve and tricuspid valve.