554 results about "Left ventricular size" patented technology

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool. Providing cardiac parameters in real-time, along with warnings about adverse effects and recommendations to support cardiac function, such as increasing or decreasing the volumetric flow rate of blood pumped by the device, administering pharmaceutical therapies, and / or repositioning the blood pump allow clinicians to better support and treat cardiovascular disease.

Systems for delivering a device for regulating blood pressure across a patients atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

The invention provides a preparation method of a left ventricular assist device, the left ventricular assist device comprises a micro pump head, a transmission shaft and a driving control mechanism, the micro pump head comprises a pump head impeller and a pump head transmission assembly, the transmission shaft comprises a mandrel and a twisting shell, and the driving control mechanism comprises a twisting shell driving module and a mandrel driving module. The method comprises the following steps that a pump head transmission assembly penetrates through a pump head impeller, and the far end and the near end of the pump head impeller are fixed to the far end of the pump head transmission assembly and the far end of a twisting shell correspondingly; a mandrel is inserted into the twisting shell, and the far end of the mandrel and the near end of the pump head transmission assembly are fixed; the twisting shell driving module is arranged at the far end of the mandrel driving module and is detachably connected with the mandrel driving module, and the far end of the twisting shell driving module is in transmission connection with the near end of the twisting shell; and the far end of the mandrel driving module is in transmission connection with the near end of the mandrel. According to the scheme, the left ventricle auxiliary device with the instrument micro-size and the high blood supply flow can be obtained, and the use safety and the working efficiency of the left ventricle auxiliary device are improved.

The invention provides a micro pump head and relates to the technical field of micro pumps, the micro pump head is applied to a left ventricular assist device, the left ventricular assist device further comprises a transmission shaft and a drive control mechanism, and the micro pump head comprises a pump head impeller and a pump head transmission assembly. The near end of the pump head impeller is in transmission connection with a twisting shell driving module of the driving control mechanism through a twisting shell of the transmission shaft, and the near end of the pump head transmission assembly is in transmission connection with a mandrel driving module of the driving control mechanism through a mandrel of the transmission shaft. The mandrel driving module drives the mandrel and the twisting shell to rotate synchronously so as to drive the far end and the near end of the pump head impeller to rotate together, and the twisting shell driving module drives the twisting shell and the mandrel to rotate relatively so as to drive the near end of the pump head impeller to rotate relative to the far end. The micro pump head can be unfolded or folded to change the outer diameter size of the micro pump head in the human body, so that the blood supply efficiency and the use safety of the auxiliary device are improved.

An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engageable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and / or platelet activation.

The invention provides a clinical diagnosis and treatment path generation method and system for tracking a chest pain patient. Wherein a dynamic spatio-temporal data atlas is constructed by synchronously collecting respiratory rhythm phase difference, coronary artery calcification integral and hypersensitive troponin curve slope, and risk degree transition signals are generated by coupling analysis of ST segment elevation amplitude asymmetric growth, left ventricular ejection fraction attenuation gradient and B-type natriuretic peptide release rate. In the acute stage, the constraint relation between a vascular recanalization time window and thrombolysis taboo is dynamically bound, in the subacute stage, a phase synchronization rule for enhancing CT scanning and anticoagulant drug dosage is established through a multidisciplinary interface, intravascular ultrasonic plaque morphological mutation characteristics and extracorporeal circulation parameters are fused, the blood supply reconstruction time sequence is dynamically adjusted based on a myocardial oxygen consumption balance equation, and the thrombolysis time sequence is determined. And path self-optimization is realized through space-time superposition of an interventional therapy delay parameter and a drug metabolism curve. According to the technical scheme provided by the invention, chest pain diagnosis and treatment path dynamic optimization and multi-modal parameter collaborative decision-making are realized, and the risk layering precision and the treatment timeliness are improved.

The invention relates to the technical field of medical image analysis, in particular to a left ventricular compliance assessment method and system based on medical image.The method comprises the following steps that a planar three-dimensional coordinate from a left ventricular apex to a mitral annulus is obtained through a CT image, a thin-plate spline interpolation algorithm is called to establish a left ventricular long-axis model, the ultrasonic end-stage internal diameter is obtained synchronously, and a left ventricular compliance assessment result is obtained. And inputting the left greenhouse long axis model and the ultrasonic diastole end-stage inner diameter into an Euclidean distance calculation function to generate a left greenhouse length-diameter ratio. According to the method, a left greenhouse long axis model is constructed by integrating CT three-dimensional coordinates and ultrasonic inner diameter, the length-diameter ratio is calculated by combining Euclidean distance, point cloud registration is carried out, a myocardial wall area is segmented, local deformation is quantized by utilizing Gaussian curvature gradient, a correction factor is generated by inputting a radial basis function network, and a parameter coupling mechanism is established by fusing an aorta root angle. And optimizing the weight of the pressure-volume equation, establishing a dynamic model, and realizing a quantitative evaluation system of spatial heterogeneity and time continuity.

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

The invention provides an echocardiogram video abstraction method based on a hierarchical space-time attention mechanism, and the method comprises the steps: obtaining an echocardiogram, inputting the echocardiogram into an anatomy and physiological basic model of a key frame recognition task, and obtaining key frame information; inputting the key frame information into a multi-dimensional spatial-temporal feature extraction model to obtain feature information and frequency domain information; fusing the feature information and the frequency domain information; performing key frame enhancement processing on the fusion information by adopting an SE channel attention mechanism to obtain key frame anatomical feature expression; processing the key frame anatomical feature expression by adopting a key frame backtracking strategy and a classification network to obtain a key frame identification classification result; performing left ventricle segmentation on the classified image by adopting an improved U-Net left ventricle region segmentation network; estimating the area and volume of the left ventricle based on a segmentation result; fusing the estimated left ventricular area and volume by adopting a hierarchical attention mechanism and a cross-layer information fusion strategy to obtain a ventricular volume result; according to the method, through abstract extraction of the key information of the ultrasonic cardiac video, the clinical practicability of intelligent screening and auxiliary diagnosis of cardiovascular diseases based on ultrasonic is improved.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

The exemplified methods and systems facilitate the quantification of cardiac cycle-variability as a metric of signal quality of an acquired signal data set and the rejection, based on that quantification, of said acquired signal data set from one or more subsequent analyses that can predict and / or estimate a metric associated with the presence, non-presence, severity, and / or localization of abnormal cardiovascular conditions or disease, including, for example, but not limited to, coronary artery disease, abnormal left ventricular end-diastolic pressure disease (LVEDP), pulmonary hypertension and subcategories thereof, heart failure (HF), among others as discussed herein. The quantification of levels of cycle-variability assessed noise such as skeletal-muscle-related-signal contamination and muscle-artifact-noise contamination, and other asynchronous-noise contamination in an acquired signal can be subsequently used for the automated rejection of such asynchronous noise from measurements of biophysical signals.

Systems and methods for delivering a device for regulating blood pressure across a patient's atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

An implantable medical device, comprising a left ventricular, LV, electrode assembly for connection to the myocardium of the left ventricle of a patient's heart and configured for application of left ventricular pacing, LVp, and for left ventricular sensing, LVs, and a control unit, configured to control the LV electrode assembly with respect to an application of LVp at a scheduled LV stimulation time, the control including inhibiting LVp during a left ventricle upper rate interval, LVURI, for T-wave protection, wherein a start of the LVURI is triggered by an LVs or LVp event. The control unit is further configured, if the scheduled LV stimulation time falls into the LVURI, to apply LVp when the LVURI lapses.

The embodiment of the invention relates to a processing method and device for predicting ejection fraction retention type heart failure. The method comprises the steps that a deep learning model used for conducting dichotomy prediction on the ejection fraction retention type heart failure is constructed and recorded as a first prediction model; constructing a model data set and recording the model data set as a first data set; training the first prediction model based on the first data set; after model training is finished, heart structure feature analysis, heart hemodynamic feature analysis and left ventricle vortex time sequence feature analysis are conducted on four-dimensional blood flow heart magnetic resonance imaging data input by a user to obtain a corresponding structure feature set, and the hemodynamic feature set and the vortex time sequence feature form a corresponding first feature data set; and inputting the first feature data set into a first prediction model for prediction to obtain a corresponding first classification vector which is fed back to the current user. According to the invention, the prediction accuracy and the prediction efficiency can be improved.

The invention provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disturbance. The monascus composition comprises one or more of cortex mori, ramulus mori and folium mori, monascus and radix puerariae. When the composition containing the red yeast rice is applied to preparation of the medicine for preventing and / or controlling coronary microcirculation disturbance, the abnormal microvascular structure can be improved (myocardial microvascular density MVD is increased, edema around microvessels is relieved, the lumen stenosis phenomenon is improved, and the endothelial cell condition is good); 2) microvascular occlusion is improved (pathologic results show that microvascular contents are reduced); (3) the abnormal vasodilatation and contraction function of the microvessels is improved (NO is increased); 4) improving blood lipid metabolism disorder; and (5) the heart function is improved (the left ventricular ejection fraction LVEF and the left ventricular short axis shortening rate LVFS are improved, and the left ventricular pressure maximum rising rate LV + dp / dtmax and the left ventricular pressure maximum falling rate LV-dp / dtmax are increased).

A method of delivering a pacing lead may include locating a potential implantation site adjacent to or within the triangle of Koch region of a patient's heart. The method may include advancing a pacing lead to the potential implantation site. The pacing lead has an elongate body and a fixation element coupled to a distal portion and attachable to the right-atrial endocardium adjacent to or within the triangle of Koch region. The method may include implanting the pacing lead at the potential implantation site to or sense electrical activity of the left ventricle in the basal and / or septal region of the left ventricular myocardium of the patient's heart. The pacing lead may include a lumen configured to receive a guide wire. A sheath of a delivery system used to deliver the pacing lead may include two or more curves to facilitate implanting the pacing lead at the implantation site.

A method, for use at a mitral valve of a heart of a subject, is provided which includes advancing a transluminal sheath into a femoral vein of the subject, through an inferior vena cava of the subject, into a right atrium of the subject, and transseptally into a left atrium of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of the mitral valve. An anchor is implanted by advancing the anchor out of the surrounding-sheath into a left ventricle of the subject, such that the anchor helically wraps around left ventricular mitral valve tissue. The surrounding-sheath is then extracted from the heart and then, a guide wire is advanced through the transluminal sheath. Other embodiments are also described.

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

The invention provides a preparation method of a micro pump head, and relates to the technical field of pump head preparation, the preparation method of the micro pump head comprises the step of preparing a pump head impeller, and the step of preparing the pump head impeller comprises the following steps: arranging an impeller framework wire between a near-end fixing ring and a far-end fixing ring in a spiral shape; preparing an impeller blade surface by using the impeller blade surface mold and an elastic raw material; the far-end fixing ring is fixed, the near-end fixing ring is rotated in the spiral direction of the impeller framework wire, the impeller framework wire is pre-tightened to be in a multi-period spiral shape, then the impeller blade face is arranged on the surface of the pre-tightened impeller framework in a sleeving mode, the pre-tightening force is released, the impeller framework wire recovers to be in the at least period spiral shape under the self-elasticity effect, and the impeller blade face is jacked outwards. Therefore, the spiral impeller is formed. According to the preparation method provided by the invention, the elastic micro pump head can be obtained, so that the use safety and the working efficiency of the left ventricle auxiliary device are improved.

A magnetic driver generates a magnetic field that rotates about an axis and induces nutation in a disc with an array of magnets (wobble plate). The magnetic driver can be a drive disc with an array of magnets and rotated by a drive motor, or can be electromagnetic coils sequentially energized, to provide the rotating magnetic field. The wobble plate nutates about the axis of the rotating magnetic field but is constrained from rotating about the axis. The wobble plate can be enclosed in a pump housing where nutation of the wobble plate causes pumping of a fluid to occur, such as in an implanted Left Ventricular Assist Device (LVAD) or a Total Artificial Heart (TAH). Driven in reverse, an input pumping fluid may induce nutation of the wobble plate which in turn induces rotary motion of a drive disc that drives a generator or a motor / generator.

The invention relates to the technical field of heart structure parameter measurement, and provides a heart structure parameter acquisition method, and a heart video processing method, device and equipment, which can measure relatively accurate heart structure parameters. The method comprises the following steps: obtaining a left ventricle surrounding key point set, a left ventricle cardiac cavity structure boundary and a left ventricle surrounding tissue structure boundary according to a cardiac image map of a left ventricle long-axis section; according to the left chamber long axis direction determined by the key point set around the left chamber, an inner diameter measuring line of the left chamber is obtained; and determining the inner diameter of the left ventricle and the thickness of the tissue around the left ventricle according to the intersection information of the inner diameter measuring line and the heart cavity structure boundary and the tissue structure boundary.

Transcatheter heart valve prostheses including a dual frame stent structure are disclosed herein. The dual frame stent structure includes an inner frame and an outer frame, and an outflow end of the inner frame is attached to an outflow end of the outer frame. The inflow end of the transcatheter heart valve prosthesis is disposed within and floats freely within a patient's atrium and the outflow end of the transcatheter heart valve prosthesis does not extend or only minimally extends into the patient's left ventricle of the heart to avoid obstruction of the left ventricular outflow tract (LVOT).

A method is provided that includes inserting an inflow cannula of a left ventricular assist device (LVAD) of a LVAD system into a left chamber of a heart of a patient transeptally via a right atrium and a superior vena cava (SVC). An outflow cannula of the LVAD is coupled to a left subclavian artery or a left axillary artery. Other embodiments are also described.

The invention discloses an application of pentagalloylglucose (PGG) in preparation of a medicine for resisting doxorubicin cardiotoxicity. The method comprises the following steps: inducing doxorubicin (DOX), establishing a myocardial cell H9C2 injury model, and determining the DOX-induced myocardial cell injury minimum concentration; after 20 [mu] M of PGG is added into a treatment group, DOX-induced H9C2 cell apoptosis can be significantly improved. A mouse myocardial injury model is induced and established by DOX, and compared with a doxorubicin group, the left ventricular systolic fraction (FS%) and ejection fraction (EF%) of mice in the doxorubicin and pentagalloylglucose group are remarkably increased, the myocardial fiber structure is improved, the cytoplasm vacuolation is reduced, the serum cTnT and BNP levels are reduced, and the ROS level is reduced. The experiment proves that the pentagalloylglucose can obviously reduce the cardiotoxicity induced by the DOX.

The illustrative methods and systems facilitate one or more dynamic analyses that can characterize and identify synchronization between acquired cardiac signals and photoplethysmography signals to predict / estimate the presence, location, and / or severity of abnormal cardiovascular conditions or diseases, including, for example, but not limited to, coronary artery disease, heart failure (including but not limited to indicators of disease or condition, such as abnormal left ventricular end-diastolic pressure disease), and pulmonary hypertension. In some embodiments, statistical properties of the synchronization between the cardiac signal and the photoplethysmography signal are evaluated. In some embodiments, statistical properties of a histogram of synchronization between the cardiac signal and the photoplethysmography signal are evaluated. In some embodiments, statistical and / or geometric properties of a Poincare map of synchronization between the cardiac signal and the photoplethysmography signal are evaluated.

The invention provides an integrated structure double-ventricle independent auxiliary device and an implantation method. The device comprises double inlet paths and double outlet paths which are connected, the double inlet paths are of a double-cavity structure and comprise an inner cavity and an outer cavity, the double inlet paths are implanted through the apex of the left ventricle, the inner cavity is inserted into the apex of the funnel of the right ventricle through the corresponding ventricular septum at the opening of the left ventricle, and the outer cavity is reserved in the left ventricle; and the double outlets are respectively connected with the aorta and the pulmonary artery through the artificial blood vessel by a circulation driving device. Left and right artificial ventricle admission passages are located in the heart, and channel distortion, large blood damage and proneness to thrombus caused by long admission passages are avoided; unsmooth drainage of a right chamber or right ventricle admission passage can be avoided; the right chamber is not damaged; the whole device is small in size and convenient to implant.

The invention discloses a pulmonary arterial hypertension diagnosis and severity degree judgment prediction model based on myocardial magnetic resonance, a construction method and application. Through statistical analysis of myocardial magnetic resonance and test information of a pulmonary hypertension patient and a contrast, specific indexes of the pulmonary hypertension patient are screened out, and new clinical models for pulmonary hypertension diagnosis are respectively constructed. The model comprises five independent predictive variables: ascending aorta width, left atrial anterior-posterior diameter, left ventricular ejection fraction, pulmonary artery width and platelet level; the invention further discloses a pulmonary arterial hypertension severity prediction model. The model comprises two independent prediction variables, namely the left ventricular end diastolic volume index and the body weight. The constructed diagnosis prediction model is based on Lasso regression and Logistic regression technologies, the dependence on traditional invasive right heart catheter examination is effectively reduced, the comfort level of a patient is greatly improved, the diagnosis process is optimized, and the overall diagnosis efficiency is improved.

The embodiment of the invention provides a monitoring system and device of a ventricular assist device, and relates to the technical field of medical instruments.The system comprises the ventricular assist device and a monitoring device.The monitoring device executes the following monitoring method that a rotating speed signal of the current rotating speed of the ventricular assist device is obtained, and determine a first pressure signal of the left ventricular pressure of the patient's heart; based on the rotating speed signal and the first pressure signal, a target correlation value representing the correlation degree between the current rotating speed and the left ventricular pressure is calculated; and determining a target support state of the ventricular assist device based on a deviation between the target correlation value and a preset reference value. By applying the scheme provided by the embodiment, the support state of the ventricular assist device can be continuously and accurately monitored in real time.

The disclosure deals with methodology and corresponding apparatus / system subject matter for image-based estimation of left ventricular myocardial stiffness. Increased left ventricular myocardial stiffness is a key factor in the development and progression of heart failure. Despite the potential impact on the clinical management of heart failure, there is currently a lack of available techniques to assess left ventricular myocardial stiffness. To address this limitation, a simple protocol is disclosed for processing routine echocardiographic imaging data to estimate left ventricular myocardial stiffness, with protocol specification for patients at risk for heart failure with preserved ejection fraction, for both sensitivity and translational feasibility of the obtained estimates of left ventricular myocardial stiffness.