205 results about "Left atrium" patented technology

To provide a device assembly and a method for treating heart failure by normalizing an elevated blood pressure in the left atrium of the heart of a mammal.SOLUTION: Disclosed herein is a transcatheter interatrial septum excision device assembly configured to create a sized interatrial aperture between right and left atria of a heart for relief of an elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a first catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the components to and from the right atrium, a tissue retention mechanism, and an optional coaxial alignment mechanism.SELECTED DRAWING: Figure 1

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

The invention discloses a method for quantitatively analyzing a left auricle occlusion effect based on a CT image. The method comprises the following steps: step 1, acquiring a heart CTA image; 2, performing three-dimensional reconstruction to obtain a heart three-dimensional image, and obtaining a left atrium three-dimensional image by using the left atrium segmentation model; 3, obtaining a left auricle occluder area by using the left auricle occluder segmentation model; 4, constructing a three-dimensional model of the left auricle occluder on the basis of the segmented left auricle occluder area so as to obtain a three-dimensional image of the left auricle occluder; 5, obtaining a three-dimensional plane of the left auricle plugging device, a front view of the plugging device and a left auricle opening plane; 6, left auricle occlusion postoperative evaluation parameters are extracted, wherein the parameters at least comprise the size, position and classification of residual shunt, the position of an occluder, the shoulder exposing position and height, the endothelialization degree of the occluder and the position of instrument-related thrombus; and 7, evaluating the left auricle occlusion effect according to the obtained evaluation parameters after the left auricle occlusion operation.

The invention discloses a heart AI system based on deep learning, and relates to the technical field of medical image processing, and the heart AI system comprises a two-dimensional fully-supervised left atrium segmentation algorithm module, a three-dimensional semi-supervised left atrium segmentation algorithm module, and a whole heart segmentation algorithm module. Meanwhile, through combination of Transform and a residual network, semantic information in the image is captured in a larger visual field, so that the segmentation precision of the network is improved; a two-dimensional fully-supervised left atrium segmentation algorithm module based on axial attention is provided from a two-dimensional angle by taking UNet as a basic model, the algorithm module firstly constructs a double-layer residual error convolution module, gradient information is transmitted through a plurality of paths, then a task-driven feature enhancement module is introduced to optimize feature representation, and finally, a task-driven left atrium segmentation algorithm is constructed. A multivariate feature fusion module is designed to integrate features, and finally a feature coupling module is designed, so that the limitation of traditional convolution operation is overcome.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

A method, for use at a mitral valve of a heart of a subject, is provided which includes advancing a transluminal sheath into a femoral vein of the subject, through an inferior vena cava of the subject, into a right atrium of the subject, and transseptally into a left atrium of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of the mitral valve. An anchor is implanted by advancing the anchor out of the surrounding-sheath into a left ventricle of the subject, such that the anchor helically wraps around left ventricular mitral valve tissue. The surrounding-sheath is then extracted from the heart and then, a guide wire is advanced through the transluminal sheath. Other embodiments are also described.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

The invention relates to the technical field of artificial blood vessels, and discloses an artificial blood vessel for coronary artery bypass grafting and a preparation method thereof. The artificial blood vessel is prepared from the following raw materials: collagen and a solvent, the solid-to-liquid ratio of the collagen to the solvent is (3-5) g: 100mL. The artificial blood vessel provided by the invention takes collagen as a raw material, the raw material composition is simple, the inner caliber of the artificial blood vessel is 1.61 + / -0.1 mm, the length is greater than or equal to 13mm, the wall thickness is 298 + / -35 microns, and the suture retention strength is 2.1 + / -0.2 N; compared with coronary arteries of a left atrial anterior branch, a left atrial rotary branch, a sinus atrial node branch and a right atrial anterior branch, the coronary artery has no obvious difference in inner caliber, wall thickness and suture retention strength, has equivalent mechanical properties, and is suitable for being used as a substitute material of autologous blood vessels of the parts.

Apparatuses and methods for performing transseptal extracorporeal membrane oxygenation are disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. The catheter system may include coaxially arranged and independently moveable venus and arterial sheaths having independently positionable openings for removing blood from the patient and for returning oxygenated blood to the patient, e.g., within the aorta.

The invention relates to the technical field of medical instruments, in particular to a valve stent for mitral valve replacement, which comprises an integrally formed stent, the stent is formed by a plurality of folding parts along the circumferential direction and the axial direction, each folding part comprises two folding arms which are connected in a V shape, and two ends of each folding arm are respectively a first connecting end and a second connecting end; the first connecting end of each folding arm is connected with the first connecting end of the adjacent folding arm in the circumferential direction, and the second connecting end of the same folding arm is connected with the second connecting end of the other adjacent folding arm in the circumferential direction; and a wave-shaped connecting rod is arranged between each folding arm and the adjacent folding arm in the axial direction. The stent has the beneficial effects that the shortening rate of the stent is effectively reduced, and implantation is more convenient through the left atrium.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The valvular implants can have a cover, a membrane, a valve, a resilient frame, and / or other features. Some valvular implants can have anchors to be positioned in the blood vessels, such as in pulmonary veins, and can anchor the implant to the heart wall. Various embodiments of covers and / or membranes act as valves contracting and expanding, to alternately permit and block blood flow. The valvular implants can cover one or more blood vessels, such as one, two, three, or four pulmonary veins, and can also be configured and implanted to block an appendage to the heart, such as the left atrial appendage.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium, through the mitral valve, and into the left ventricle. A ventricular anchor is deployed from the catheter and into a wall of the left ventricle, leaving a ventricular suture attached to the ventricular anchor and extending proximally through the catheter. A leaflet anchor is deployed to secure a mitral valve leaflet to a leaflet suture, with the leaflet suture extending proximally through the catheter. The leaflet suture is secured to the ventricular suture to limit a range of travel of the leaflet in the direction of the left atrium. Also disclosed is an assembled in situ mitral valve leaflet restraint, having a neo papillary muscle and a neo chordae tendinea.

A method of reducing left atrial pressure is provided for treating diastolic heart failure. A puncture catheter is advanced into a coronary sinus for creating an opening in a wall between the coronary sinus and a left atrium of a heart. A cauterizing tool may be used to create a controlled scarring pattern in the tissue along the opening. After the opening is created, a blood flow path is provided from the left atrium to the coronary sinus for reducing blood pressure in the left atrium and thereby alleviating symptoms of heart failure. If necessary, a shunt device may be implanted within the opening to ensure that the blood flow path remains open.

The utility model provides a rapid non-exchange puncturing and conveying system for heart patent foramen ovale plugging. The rapid non-exchange puncturing and conveying system comprises a conveying sheath body and an expansion inner core. The conveying sheath body comprises a sheath head section, a bending adjusting section, a pipe body section and a connector section which are sequentially arranged. The total length of the sheath head section and the bending adjusting section is 2-3 cm, the length of the bending adjusting section is 0.5-1 cm, and the bending degree of the bending adjusting section is adjustable. The expansion inner core is arranged in the conveying sheath body in a penetrating mode. The conveying sheath body, the expansion core and the plugging device assembly system can smoothly complete the conveying sheath to enter the left atrium through the patent foramen ovale and complete the plugging device release operation, particularly, the bending adjusting section is designed to be adjustable in bending, the conveying sheath is more suitable for right atrium operation of different forms, the instrument exchange step in the existing operation process is reduced, and the operation efficiency is improved. The risk that an atrium and an atrial appendage are damaged by an existing material is reduced, the operation time can be remarkably shortened, and a very simple patent foramen ovale plugging operation is achieved.

Systems, devices and methods are provided for supporting cardiac function. A device comprises an elongate housing configured for implantation into a patient exterior to the chest cavity. The housing includes a first inlet and an outlet that define a primary blood flow path from the left atrium through at least a portion of the housing within the right atrium, and to the aorta. The housing comprises a motor disposed within the housing and an impeller coupled to the motor for pumping blood from the first inlet to the outlet of the housing through the primary blood flow path. The device bypasses the left ventricle by drawing freshly oxygenated blood from the left atrium and propelling this blood directly into the aorta. Implanting the pump exterior to the chest cavity is less invasive and allows the pump to be quickly and easily repaired, cleaned, repositioned and or replaced without removing or replacing the tubes that are anchored to sensitive tissue structures within the thoracic cavity.

The invention provides an automatic counting method and system for ultrasonic microbubbles in right heart acoustic radiography. The method comprises the following steps: acquiring a cardiac radiography image of a patient through high-resolution ultrasonic equipment; extracting a region of interest of the cardiac angiography image based on the cardiac vascular structure, and performing image registration operation on the cardiac angiography image by taking the region of interest as a reference point to obtain a registered image; carrying out pixel-by-pixel addition on two frames of pulse images with opposite phases in the registered image to obtain an enhanced image; determining the high-echo bright spots in the enhanced image as suspected microbubbles, and performing denoising processing according to the feature similarity to obtain real microbubbles; judging pathological conditions according to whether real microbubbles exist in the left atrium or not; if the real microbubbles exist in the left atrium, grading the abnormal blood flow according to the change data of the microbubbles in the left atrium and the right atrium. According to the method, through high-precision image registration, multi-modal feature analysis and dynamic parameter fusion technologies, the microbubble detection accuracy is improved, and quantitative grading of pathological conditions is achieved.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.

Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve. A distal anchor zone or portion coupled with the proximal end can extend and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The catheter apparatuses may be positionable using a steering device. The valve repair device detachably connects the distal and proximal ends of the catheter. The valve repair device can be detached using low profile devices actuatable from the proximal or distal ends, e.g., at a venous or arterial access site.

The invention discloses a hemodynamic test system of a pulsating type ventricular assist device. The test system comprises a left atrium cavity, a left ventricular cavity, an aorta cavity, a vein cavity and a pulsating blood flow generator module. Two ends of the aortic valve module are respectively connected with the left ventricular cavity and the aortic cavity; the ventricular auxiliary device sequentially penetrates through an aorta cavity, an aortic valve module and a left ventricular cavity through a sealing tool of the aorta cavity, a blunt end is arranged in the left ventricular cavity, and a two-way valve is arranged in the aorta cavity. The pulsating blood flow generator module is connected with the left ventricular cavity, the left ventricular cavity is filled with liquid, the left ventricular model is extruded through reciprocating motion of a piston, and therefore the flowing rule of human blood is simulated. The test system can be used for simulating the front load and the rear load of the pulsating type ventricular assist device and detecting the hemodynamic performance of the ventricular assist device after the ventricular assist device is implanted into a human body, and structural optimization of the ventricular assist device and design of a controller are facilitated.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.

The present invention discloses a closure device for mitral valve leaflet repair, which relates to the technical field of mitral valve leaflet repair. The present invention includes an upper jaw assembly, one side of the upper jaw assembly is set to an opening shape, and a positioning clamp assembly is slidably connected to the inner wall of the opening. The end of the positioning clamp assembly is provided with an outer protrusion, and the top of the upper surface of the outer protrusion is provided with a hook-shaped groove. The present invention utilizes the continuous abutment and approach of the closure assembly to finally connect the port with the clamp arm, thereby forming an integrated structure between the closure assembly and the two clamp arms, so that the closure assembly is connected to the bottom of the mitral valve, and the first clamp arm and the second clamp arm are connected to the top of the mitral valve. Therefore, during the systole of the heart, the mitral valve is tightly closed, preventing blood from the left ventricle from flowing back to the left atrium, thereby ensuring that blood can be pumped from the left ventricle into the aorta in the correct direction, and the closure assembly can be closed without relying on external force. Compared with the existing technology, the external operating structure for controlling the turning is saved.

The invention discloses a self-adaptive control method and equipment based on an external counterpulsation device and a medium, and relates to the technical field of hemodynamics, and the method comprises the following steps: obtaining the gas inflation and deflation speed of the external counterpulsation device, carrying out air bag volume accumulation analysis on the gas inflation and deflation speed, and determining air bag volume data; based on the air bag volume data, through air bag pressure change analysis, blood vessel pressure data generated by the air bag on the limb is obtained; according to the blood vessel pressure data, the blood inflow amount of the left atrium is determined through blood backflow state analysis in the diastolic period; performing left ventricular ejection stroke-per-volume analysis on the left atrium blood inflow in a systolic period to obtain cardiac output data; based on cardiac output data or gas inflation and deflation speed, a self-adaptive regulation and control strategy of the in-vitro counterpulsation device is determined through real-time analysis of hemodynamic parameters. By means of the method, the problem that in the prior art, the external counterpulsation device cannot be adjusted in real time according to the current state of the user is solved.

Docking devices for securing a prosthetic valve at a native valve are provided. The docking device can include a coil and a guard member. The coil includes a plurality of helical turns when in a deployed orientation. The guard member may be attached to the coil by being coupled to at least a portion of a helical turn thereof. The docking devices include a atrial functional turn configured to enhance the transient stage stability of the docking device in the left atrium of the heart.

The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and / or a geometry of a lumen orifice to control the flow of blood through the lumen.

Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.

The present disclosure relates to a device assembly and a method for treating heart failure by normalizing elevated blood pressure in the left atrium of a heart of a mammal. Disclosed herein is a transcatheter interatrial septum excision device assembly configured to create a sized interatrial aperture between the right and left atria of a heart for the relief of elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a first catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the aforementioned components to and from the right atrium, a tissue retention mechanism and an optional coaxial alignment mechanism.