6 results about "Native tissue" patented technology

Particulated and reconstituted tissues comprising small, densely packed tissue microparticles encapsulated in a tissue specific promoting gel packed at a percolation threshold that can be transplanted into damaged tissue thereby facilitating regeneration following trauma to the tissue. The engineered microparticle construct for tissue replacement and repair, as taught herein, provides numerous benefits including (1) encouraging a regenerative response in damaged tissue regions, (2) mimicking the structural support of native tissue, (3) establishing an environment that promotes attachment, migration, and differentiation of infiltrating stem cells, and (4) providing a source of growth factors and other anti-catabolic growth factors and cytokines. Tissue specific microparticles packed together at, or past, their percolation threshold will provide the necessary mechanical environment and to best recapitulate and integrate with native tissue. The packing of microparticles, derived from the ECM of native tissue to a concentration past the percolation point will yield both the necessary biochemical and biomechanical properties necessary for reconstituting a specific tissue.

The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and / or a geometry of a lumen orifice to control the flow of blood through the lumen.

An assembly for the tricuspid orifice of a human heart has an external frame connected to an internal stent carrying a tricuspid valve bioprosthesis and a sealing skirt. The external frame is configured to hold its position in the native tricuspid annulus. The internal stent is connected to the external frame by one or more fixing strands. The sealing skirt covers the interstitial space existing between the external frame and the internal stent. Developments are described which include the use of a deformable region of the frame, various alternative embodiments of the sealing skirt, the use of a frame composed of multiple sub-sections, the use of fixing strands between the stent and the frame and of fixing elements for fixing the assembly to the native tissue, the use of sensors and / or actuators, and also the use of a stent in the inferior vena cava. Method aspects are also described.

Described herein are methods for preserving biomaterials by vitrification while reducing or preventing the loss of viability associated with conventional preservation methods. Also described herein are cassettes and methods for using these cassettes for cryopreserving biomaterials (e.g., a bioengineered construct or natural tissue sample).

This application belongs to the field of cell biology and tissue engineering technology, specifically relating to a method and composition for in vitro regeneration of meibomian gland organoids. This application identifies Prom1⁺ cells, bipotent progenitor cells capable of maintaining meibomian gland homeostasis, at the acinar-duct junction. This application establishes a three-stage organoid culture system that enables the expansion and culture of meibomian gland-derived somatic cells containing Prom1⁺ cells. By precisely controlling signal transduction at specific stages, the developmental trajectory of meibomian gland tissue is accurately reproduced, generating functional organoids. These organoids exhibit high transcriptional fidelity to natural tissues and significantly retain the natural lipid profile. The method of this application is applicable to culturing starting cell populations containing Prom1⁺ cells to obtain functional meibomian gland organoids, providing a high-fidelity model for studying meibomian gland biology, simulating meibomian gland degeneration (MGD), and developing cell-based DED therapies.

The utility model provides a kind of artificial heart valve, comprising: support, covering film, multiple first connecting line and multiple second connecting line, support includes multiple cross connection and form grid structure's support pole, grid structure includes multiple mesh units, each mesh unit includes multiple connecting portion and the section of support pole connected between adjacent two connecting portions;Support includes mutually connected first flange section and first leaf segment;Covering film includes mutually connected flange connecting section and first leaf connecting section;Each mesh unit is connected at least with one first connecting line, and first connecting line is used to connect first flange section and flange connecting section together and connect first leaf segment and first leaf connecting section together;The connecting portion of each mesh unit of first leaf section is spirally wound with second connecting line.The artificial heart valve of the utility model can solve the problem of support bruising native tissue, reduce the risk of covering film binding support.