37 results about "Pulmonary capillary bed" patented technology

Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.

The invention regards an adhesive patch for oscillatory blood pressure measurements of a subject, the patch comprising: an actuator arranged for application of an external pressure onto a target part of the circulatory system of the subject; a pressure sensor arranged in connection with the actuator, wherein the pressure sensor is adapted to measure the external pressure; wherein the patch is arranged to obtain oscillatory blood pressure measurements of the target part by setting the external pressure applied to the target part above a systolic blood pressure, and thereafter gradually releasing the external pressure until it is below a diastolic blood pressure, while measuring, by the pressure sensor, resulting pressure oscillations of the actuator.

The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by\operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

The inhalation suspension preparation containing the SGC receptor stimulant comprises the SGC receptor stimulant with an effective therapeutic dose or pharmaceutically acceptable salt of the SGC receptor stimulant, and pharmaceutically acceptable auxiliary materials of the suspension preparation, the pharmaceutically acceptable auxiliary materials of the suspension preparation comprise at least one of a surfactant, a pH regulator, an osmotic pressure regulator and a metal complexing agent; the inhalation suspension preparation containing the riociguat shows good lung absorption efficiency, is beneficial to reaching the same or better treatment level by reducing the administration dosage, can directly act on a diseased region through an administration route, takes effect more quickly compared with oral administration of the riociguat, and has a good application prospect. Gastrointestinal discomfort and systemic hypotension side effects caused by gastrointestinal tract contact and absorption entering a circulatory system can be avoided, the treatment cycle of an oral dosage form dosage titration administration scheme is shortened, and a better treatment scheme is provided for relieving dyspnea and syncope symptoms of pulmonary hypertension patients treated at home.

The systems and methods of the present invention can remove target material (including blood clots) from body parts (including but not limited to the circulatory system) for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebral vascular embolism, and other vascular obstructions. The capture system may include a tubular body and an end having an opening and a capture guide. In some embodiments, the body or funnel tip of the catheter is expandable.

Methods and apparatus disclosed herein relate to graphical representation of patient hemodynamic state. In various embodiments, one or more measured physiological parameters of a patient may be analyzed. Based on the analysis, a graphical user interface (GUI) may be rendered. The GUI may include a figure-eight schematic (222, 1222) that represents a circulatory system of the patient. The figure-eight schematic may include: a first loop (224, 1224) that represents pulmonary circulation of the patient; a second loop (226, 1226) that represents systemic circulation of the patient; and a central object (228, 1228) that connects the first and second loops represents a heart of the patient. In various embodiments, each of the first and second loops includes multiple arc fragments, with each arc fragment being shaped to convey one or more of the measured physiological parameters of the patient.

Methods and devices for increasing oxygenation levels in the blood supply and thereby treating the condition of hypoxemia. Multiple approaches such as pressure reduction in the pulmonary circulatory system, reducing triggering mechanisms in the main pulmonary artery and restricting flow in the pulmonary circulatory system are disclosed. Interventions associated with those approaches can including shunting, restrictors, compliance devices, pharmacologic substances, etc.

The embodiment of the application discloses a kind of vein bionics microfluidic chip and its preparation and application method of simulating multi-organ interconnection.The chip includes a chip main body, and its microfluid channel system integrates at least three organ simulation units: a lung simulation chamber for culturing lung cells to simulate upstream organs that can produce systemic effects;An upstream colon cancer cell culture chamber for three-dimensional culture of colon cancer cells to simulate tumor primary lesions;And a downstream liver cell culture chamber for three-dimensional co-culture of liver cells and vascular endothelial cells to simulate the target organ of liver, and the three simulation chambers are communicated with each other by a vein bionics microfluid network, which simulates the complex blood circulation system of human body (including pulmonary circulation and systemic circulation), can realize the signal molecule transmission between organs, and simulate the invasion and metastasis process of colon cancer cells to the target organ of liver via the circulatory system after being affected by upstream lung signals.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

The disclosure relates to a system comprising a device that includes electrodes and a sensor operably connected in electrical communication with a controller housing a computer program product that calculates heart rate and mean arterial blood pressure in the circulatory system of a subject by the sensor being placed at or proximate to the cardiac tissue of the subject. Electrodes on the device stimulate the vagal nerve to restore heart rate and arterial blood pressure to normal levels if an abnormality is detected.

A method (200) for determining the total flow rate of exhaust gas exiting a gas exchange device (110) coupled to the circulatory system of a patient (10) is disclosed. The gas exchange device is configured to provide oxygen-rich blood to the circulatory system by exposing oxygen-deficient blood to oxygen provided by an incoming gas and to allow the passage of excess oxygen into the exhaust gas. The method involves the step of determining the total flow rate of exhaust gas from the concentration and flow rate of oxygen leaving the gas exchange device. The concentration is recovered from a sensor, while the flow rate is determined based on a mass equilibrium approach, and the amount of oxygen leaving the gas exchange device corresponds to the difference between the amount of oxygen supplied to the gas exchange device and the amount of oxygen absorbed by the blood during gas exchange.

A Windkessel simulation apparatus includes a flexible fluid container that cyclically fills with a perfusate fluid, such as blood, and helps deliver the perfusate fluid to a heart, by means of an elastic reactive squeezing mechanism that applies compressive force proportional to the pressure in the flexible fluid container. The apparatus acts as a hydraulic capacitor, similarly to how arteries act in the body-inflating during systole, and squeezing during diastole. In this way, the apparatus may help simulate a natural circulatory system for an organ, such as an ex vivo heart.

A system (100) is disclosed, comprising a fluid exchange module (110) configured to be coupled to an extracorporeal circuit (105), circulating blood of a circulatory system of a patient, to transfer a fluid component between the blood and an exchange medium flowing through the fluid exchange module. The system further comprises a gas exchange device (120) configured to be coupled to the extracorporeal circuit to transfer a gas component between the blood and a reference sweep gas passing through the gas exchange device, a reference gas circuit (130) configured to be operated as a closed circuit recirculating the reference sweep gas through the gas exchange device, and a sensor unit (140) configured to be coupled to the reference gas circuit to generate sensor data indicating a concentration or partial pressure of the gas component in the recirculated reference sweep gas.

The application discloses a diving decompression sickness dynamic prediction and risk assessment system of multi-tissue parallel computation, relates to the fields of diving medicine, high-pressure medicine and human physiology modeling, and comprises a tissue unit planning module, a central blood circulation and coupling module and a model calculation and risk assessment module. The system divides a human body into a plurality of core physiological tissue units, and plans each tissue unit as a hybrid model composed of three sub-units of "fast-middle-slow". Then, the system simulates a human circulatory system by defining cardiac output, arterial blood inert gas partial pressure and dynamically distributing blood flow according to the tissue type, so as to construct a simulation model. Finally, according to the environmental pressure-time profile corresponding to a diving plan and the breathing gas composition, the simulation model is used to parallelly calculate the inert gas tension of all tissue units and sub-units, so as to be used for dynamic prediction and risk assessment of decompression sickness. The application provides a higher safety margin for saturation diving and repeated diving.

Devices, systems, and methods provide measurements of continuous cardiac output (CCO). A pulmonary artery (PA) catheter—for example, a Swan-Ganz catheter—can be utilized to obtain multiple pressure measurements simultaneously from different locations within the circulatory system, such as in a pulmonary artery, right atrium, right ventricle, vena cava, etc. Continuous pressure measurements from multiple points can provide estimates of heart rate and stroke volume allowing computation of cardiac output along with each beat of the heart without the need for thermodilution.

An apparatus and method for estimating one or more hemodynamic parameters (e.g., cardiac output or stroke volume). Embodiments are based on the idea of incorporating information about vascular tone into hemodynamic parameter estimation to improve accuracy. More specifically, embodiments use measurements of the duration of travel of a blood pulse from the heart along a particular length of an arterial path as a proxy measure for vascular tone and incorporate it into hemodynamic parameter estimation. Embodiments also account for changes in vascular tone between different parts of the circulatory system based on incorporating vascular tone proxy measurements for multiple different arterial paths.

The invention relates to a monitoring instrument with a blood pressure analysis function, comprising: an acquisition module for continuously acquiring blood pressure and pulse oxygen in real time to obtain a blood pressure wave and a pulse oxygen wave; the data processing module is used for analyzing the characteristic parameters of the blood pressure waves and the pulse oxygen waves to obtain the heart rate, the pulse rate, the stroke volume, the cardiac output, the effective arterial elasticity, the arterial closure pressure, the tissue perfusion pressure and the arterial resistance; the display module is used for displaying the heart rate or the pulse rate, the stroke volume, the cardiac output, the effective artery elasticity, the artery closing pressure and the vascular resistance in real time. By analyzing the characteristic parameters of the blood pressure wave and the pulse oxygen wave and extracting multi-dimensional parameters reflecting the hemodynamic state, including stroke volume, cardiac output, effective arterial elasticity, closing pressure, tissue perfusion pressure and the like, medical staff can be helped to more comprehensively know the circulatory system state of a patient, and the circulatory system state is not limited to basic systolic pressure and diastolic pressure information, so that the medical staff can more comprehensively know the circulatory system state of the patient. And a treatment scheme is timely adjusted and a treatment effect is evaluated.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

1. The name of the design product: hemodynamic parameter display bar of display respiration and circulatory system parameter graphical user interface for electronic equipment. 2. The use of the design product: an electronic equipment. 3. The design points of the design product: in the graphical user interface. 4. The picture or photo that best shows the design points: front view. 5. The design contains colors. 6. The use of the graphical user interface: the design product displays the respiration and circulatory system parameter graphical user interface for displaying the respiration and circulatory system parameters of a patient, such as for a patient monitoring system; the hemodynamic parameter display bar is used for displaying the mean airway pressure (Paw), arterial blood pressure (ABP) and heart rate (HR) in the cardiopulmonary system, images of the lungs and heart and corresponding drawing lines. 7. The human-computer interaction mode of the graphical user interface: the front view is the main interface of the display respiration and circulatory system parameter graphical user interface, which is displayed according to the specific conditions of different patients.

A method (200) for determining a total flow rate of exhaust gas exiting a gas exchange device (110) coupled to a circulatory system of a patient (10) is disclosed. The gas exchange device is configured to provide oxygen-rich blood to the circulatory system by exposing oxygen-poor blood to oxygen provided by an inlet gas and to allow passage of excess oxygen to the exhaust gas. The method involves determining the total flow rate of exhaust gas from a concentration and flow rate of oxygen leaving the gas exchange device. The concentration is retrieved from a sensor, whereas the flow rate is determined based on a mass equilibrium approach, in which the amount of oxygen leaving the gas exchange device corresponds to a difference between the amount of oxygen supplied to the gas exchange device and the amount of oxygen taken up by the blood during the gas exchange.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

An electronic stethoscope with a method of listening to sounds made by a heart, a lung, or blood flow along with using soundwaves transmitted from a transducer to observe a person's circulatory system wirelessly displayed onto a nearby monitor without switching devices.

Nano-entity compositions composed of a plurality of self-associated compounds of Formula 1 and / or Formula 2, for example, 2-[(Z)-[l-(2-amino-l,3-thiazol-4-yl)-2-oxo-2-(2-oxoethylamino)ethylidene]amino]oxyacetic acid, where R1 is a carboxylic acid group and R2 is an amine group, have antifibrotic properties, effective for inhibiting type I collagen synthesis by inhibiting binding of LARP6 with a 5' stem-loop of a collagen mRNA. The described nano-entity compositions may be used in a method of treating a patient having a fibrotic condition, including but are not limited to a pulmonary fibrosis, a liver fibrosis, a heart fibrosis, a circulatory system fibrosis, a skin fibrosis, a renal fibrosis, and / or an intestinal fibrosis.

The present disclosure relates to a method for non-invasive determination of a hemodynamic parameter of a mechanically ventilated subject (3) based on a point in time (thb) of a heartbeat of the subject and an arrival point in time (tarr_pulm, tarr_sys) at which a blood pressure pulse caused by the heartbeat reaches a point of arrival in the circulatory system of the subject. The method comprises the steps of measuring (S41) a respiratory pressure and / or a respiratory flow, and determining (S43) the point in time (thb) of the heartbeat from a change in the measured respiratory pressure and / or the respiratory flow resulting from a physical impact of the heart on the lungs of the subject (3) during the heartbeat.

A method (200) for determining a total flow rate of exhaust gas leaving a gas exchange device (110) coupled to a circulatory system of a patient (10) is disclosed. The gas exchange device is configured to provide oxygen-rich blood to the circulatory system by exposing oxygen-poor blood to oxygen provided by an inlet gas and to allow excess oxygen to enter the exhaust gas. The method involves determining the total flow rate of the exhaust gas from a concentration and a flow rate of oxygen leaving the gas exchange device. The concentration is retrieved from a sensor, while the flow rate is determined based on a mass balance approach, wherein the amount of oxygen leaving the gas exchange device corresponds to the difference between the amount of oxygen supplied to the gas exchange device and the amount of oxygen taken up by the blood during gas exchange.

The present disclosure provides a pump housing having a blood flow inlet and a blood flow outlet connected by a passageway, a pump element disposed in the pump housing, and a set rate N set 1. A blood pump system comprising: a blood pump, in particular an intravascular blood pump, having a drive unit configured to drive a pump element at a set speed N ; a sensor array configured to at least intermittently sense at least one circulatory system related parameter CSRP; a controller configured to process the at least one circulatory system related parameter CSRP; and a storage device configured to continuously store the processed at least one circulatory system related parameter, wherein the controller performs a weaning procedure, in which: i) a first sequence of the processed at least one circulatory system related parameter CSRP is stored in the storage device over a first time interval; ii) a first average value AV1 for the first sequence is calculated; and iii) after the first average value AV1 has been calculated, the controller performs a weaning procedure, in which ... set is the deceleration value dN R iv) a second sequence of the processed at least one cardiovascular system related parameter CSRP is stored in a storage device over a second time interval; v) a second average value AV2 for the second sequence is calculated; and vi) a comparison value |Diff| of the difference between the first average value AV1 and the second average value AV2 is measured to be less than a predetermined threshold value TR. CSRP and vii) the controller is configured to repeat steps iv) to vi), and the comparison value |Diff| is compared with a predetermined threshold TR CSRP If it is within, the first counter C up is increased by 1, and the comparison value |Diff| is increased to a predetermined threshold TR CSRP If it is outside, the second counter C down The controller is further configured to perform a departure procedure, wherein the controller is configured to increase the first counter C by one. up is a predetermined first counter maximum value TR Cup When the first counter C reaches the first counter C, steps i) to vii) are repeated. upThe controller is configured to set a second counter C to zero. down is a predetermined second counter maximum value TR Cdown When it reaches the set speed N set is the acceleration value dN I and a second counter C down to zero and repeating steps iv) to vii).

The present disclosure relates to a blood pump system comprising a blood pump, in particular an intravascular blood pump, a sensor device, a controller and a storage device. The blood pump has a pump housing having a blood flow inlet and a blood flow outlet connected by a channel, a pump element disposed in the pump housing, and a drive unit configured to drive the pump element at a set speed (Nset) such that a flow is generated between the blood flow inlet and the blood flow outlet. The sensor device is configured to at least intermittently sense at least one circulatory system related parameter (CSRP); the controller is configured to process at least one circulatory system related parameter (CSRP); the storage device is configured to continuously store the processed at least one circulatory system related parameter; wherein the controller is further configured to execute a detachment procedure in which i) a first sequence of processed at least one circulatory system related parameter (CSRP) is stored in the storage device for a first time interval; ii) calculating a first average value (AV1) of the first sequence; iii) reducing the set speed (Nset) by a speed reduction value (dNR) after calculating the first average value (AV1); iv) storing a second sequence of processed at least one circulatory system related parameter (CSRP) in the storage device for a second time interval; v) calculating a second mean value (AV2) of the second sequence; vi) comparing a comparison value (Diff) of the difference between the first average value (AV1) and the second average value (AV2) with a predetermined threshold value (TRCSRP); vii) wherein the controller is configured to repeat steps iv) to vi) and to add 1 to the first counter (Cup) if the comparison value (Diff) is within a predetermined threshold value (TRCSRP) and to add 1 to the second counter (Cdown) if the comparison value (Diff) is outside the predetermined threshold value (TRCSRP); and wherein the controller is configured to repeat steps i) to vii) and to set the first counter (Cup) to zero when the first counter (Cup) reaches a predetermined first counter maximum value (TRCup), and wherein the controller is configured to increase the set speed (Nset) by a speed increase value (dNI) and to set the second counter (Cdown) to zero, and a controller configured to repeat steps iv) to vii) when the second counter (Cdown) reaches a predetermined second counter maximum value (TRCdown).

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

A method may include performing an echocardiogram procedure on a patient to generate a plurality of echocardiogram images; during the echocardiogram procedure, intravenously directing bubbles into a patient's venous circulatory system and to a right side of the patient's heart; identifying structures of the patient's heart and further identifying composite boundaries for the structures; after detecting presence of the bubbles on the right side of the patient's heart, comparing opacification of the right atrium to a threshold level of opacification to confirm sufficient opacification of the patient's right atrium; analyzing additional echocardiogram images relative to the composite boundaries to detect presence of the bubbles on a left side of the patient's heart; based on analyzing the additional echocardiogram images, calculating a score based on a nature of detected bubbles on the left side of the patient's heart; and based on the score initiating treatment in the patient.

A blood pump device with a leak-proof aortic adapter assembly includes a T-shaped flow connector comprising a catheter insertion portion, a collar portion, and a truss. The catheter insertion portion is connected to the collar portion and the truss is disposed in the catheter insertion portion. The inner wall of the catheter insertion portion is tapered at both ends of the catheter insertion portion and is compliantly matched to the implant site artery. The proximal end of the collar portion is configured to be connected to an inlet adapter of a blood pump. The aortic adapter assembly is provided with a quick connector type coupler and a method of installation to achieve insertable flow communication between a ventricular assist device and the human circulatory system.