The invention relates to an industrial synthesis method of tris(butoxyethyl)phosphate (TBEP) and a device thereof. Specifically, the method consists of: in the presence of a water absorbent and a catalyst, reacting ethylene glycol monobutyl ether with phosphorus oxychloride to generate a TBEP crude product, letting the TBEP crude product enter a washing tower to conduct multistage countercurrent extraction washing, then bringing the crude product into a stratification pot to conduct standing stratification, removing a saponification and aqueous layer from an upper material layer, then subjecting the obtained material layer to a distillation kettle, carrying out reduced pressure water vapor dealcoholization, introducing water vapor to the kettle bottom, conducting water vapor distillation for 0.9-1.2h, removing residual ethylene glycol monobutyl ether, and then carrying out reduced pressure dehydration and filtering to obtain a TBEP finished product. The product obtained by the method has low sodium ion content, and the tris(butoxyethyl)phosphate purity is high, the method reduces the probability of tris(butoxyethyl)phosphate degradation or loss, improves the yield, also reduces the environmental pressure, and can lower the content of sodium ions in the product without harsh distillation conditions, thereby greatly reducing the production cost, improving product quality, and increasing the economic benefits of enterprises.