1395results about "Heating or cooling apparatus" patented technology

The application discloses a pollution-preventing detection device, method and application for rapid detection of nucleic acid amplification, which comprises a detection part and a mixed reaction cabin, and the mixed reaction cabin comprises a reaction cabin main body and a reaction cabin cover which is in sealed connection with the reaction cabin main body and can be detached; a channel for connecting a hybridization liquid containing part and a mixed reaction part is arranged between the reaction cabin cover and the reaction cabin main body; the detection part comprises a detection inner core and a detection box body containing the detection inner core; a transparent observation window is arranged on the detection box body and corresponds to the reaction area position of the detection inner core; a flow guide device matched with the mixed reaction cabin is further arranged on the detection box body; the flow guide device comprises a flow guide pipe and a flow guide part; one end of the flow guide part is connected with the flow guide pipe, and the other end is connected with the detection inner core; the hybridization liquid and the sample mixed liquid are guided to the detection inner core; and the detection inner core displays the final detection result in the area corresponding to the transparent observation window. The application realizes that the liquid in the reaction tube flows out to the designated detection card in a completely closed environment, and has the advantages of good sealing effect and prevention of primer aerosol pollution.

The invention relates to a temperature control method and device and nucleic acid amplification detection equipment. The method comprises the following steps: when a main heating element reaches a target working temperature and the temperature is stable, obtaining a current combination corresponding to each auxiliary heating element according to the target working temperature and a preset corresponding relation; wherein the preset corresponding relation is the relation between the temperature and the current of the auxiliary heating piece meeting the temperature uniformity requirement; each auxiliary heating element is arranged corresponding to each temperature compensation area; and according to the current combination, an auxiliary heating element is driven to carry out temperature compensation adjustment on the temperature compensation area. The temperature uniformity can be realized, and the temperature accuracy is ensured.

The invention relates to the technical field of oil product detection, in particular to a full-automatic condensation point determinator and a determination method.The full-automatic condensation point determinator comprises a base and a test tube, the top of the base is fixedly connected with a mounting base, the surface of the base and the surface of the mounting base are provided with a test bath mechanism and a supporting mechanism, and the test bath mechanism enables a motor to drive a test bath to rotate; the rotation angle of the motor is controlled through a preset program, precise positioning is achieved, the tedious operation of hole-by-hole adjustment of the original structure is avoided, the rotating shaft is locked through mechanical clamping, angle deviation in the testing process is prevented, then manual adjustment is replaced by the motor and the electric push rod, and the test efficiency is improved. The double locking effect is achieved, accidental displacement can be prevented, and precision and efficiency are improved; according to the clamping mechanism, the four arc-shaped clamping plates apply uniform radial pressure through the first springs to clamp the outer wall of the test tube, the inner diameters of the clamping plates are gradually increased from top to bottom, and the clamping mechanism is compatible with test tubes with different outer diameters.

The invention discloses a temperature control system and method of a micro-fluidic chip, and relates to the technical field of micro-fluidic temperature control, and the method comprises the following steps: in the manufacturing process of the micro-fluidic chip, embedding topological insulator nanowires into a substrate in a directional arrangement mode to form a pre-locking array, and meanwhile, generating an anisotropic heat conduction network under the continuous action of a sound-magnetic field, a topological vortex invariant is calculated, and a heat conduction weight coefficient is generated; arranging a fluorescent layer on the surface of a micro-reaction cavity of the anisotropic heat conduction network, collecting a fluorescence lifetime attenuation curve in real time, and calculating a transient temperature value and a temperature change rate according to a heat conduction constraint variation model and a heat conduction weight system; nonlinear feed-forward compensation power is calculated according to the transient temperature value and the temperature change rate, feedback compensation power is calculated in combination with a deviation field of the target temperature and the real-time temperature, and a compensation power instruction is generated; according to the method, the thermal pilot frequency domain filtering function is constructed through the compensation power instruction, so that the uniformity and response speed of thermal response are improved.

This disclosure provides for devices, methods, and systems for generating a plurality of droplets within a collecting container at an extremely high rate (e.g., of at least 1 million droplets per minute, etc.), each of the plurality of droplets comprising an aqueous mixture for a digital analysis, wherein upon generation, the plurality of droplets is stabilized in position within a region of the collecting container. The inventions enable partitioning of samples for digital analyses at unprecedented rates, where readout of signals from targets within such partitions can still be achieved in accordance with various assays.

The invention relates to an environmental test box for realizing high and low temperature rapid alternating circulation, which is mainly applied to the technical field of environmental test equipment. The test box is provided with a high-temperature chamber and a low-temperature chamber which are independent from each other, a thermal insulation layer is arranged between the two chambers, and the test box can respectively keep constant temperature environments at the highest temperature of + 75 DEG C and the lowest temperature of-50 DEG C; during a test, a sample is placed in the test bed, and the rotating shaft structure driven by the motor periodically rotates in a reciprocating manner or rotates in the same direction among different temperature zones, so that high-low temperature rapid alternating circulation is realized. The operation mode of the motor is controlled through the control system so as to simulate the accelerated aging process of the component in the temperature rapid alternating environment. According to the test box, through the design of the control system, the forced convection fan and the middle thermal insulation layer, it is guaranteed that the temperature switching process is rapid, uniform and stable. Compared with the prior art, high and low temperature circulation can be completed without overall heating and cooling of the interior of the test box, and the test box has the advantages of being high in test efficiency, capable of remarkably improving the reliability and accuracy of the high and low temperature alternating circulation test of the sample and the like.

The utility model belongs to the technical field of test boxes, and particularly relates to a high-low temperature test box with uniform heating. Comprising test cavities which are arranged in a test box at intervals left and right; a placement net plate is embedded in the bottom of the test cavity; the fans are arranged below the placing net plate in a bilateral symmetry manner; the air inlet end of the fan is communicated with the test cavity through the placing screen plate, and the air outlet end of the fan is communicated with the air duct cavity; the air duct cavities are distributed on the left side wall and the right side wall of the test cavity in a bilateral symmetry manner; a spoiler is vertically and obliquely arranged in the air duct cavity, and an air distribution plate is arranged at the air return end of the air duct cavity. According to the utility model, through the arrangement of the spoiler and the air distribution plate in the air duct cavity, high and low temperature airflow with uniform airflow distribution can be provided for the interior of the test cavity, so that the temperature rise rates of different areas are consistent, and the uniform heating effect during product testing is further improved.

The utility model discloses a temperature-controllable asphalt concrete non-contact slope flow instrument device, which comprises a temperature control box and an angle adjusting device, the angle adjusting device comprises a bottom support, an adjusting plate and a base, the left end of the adjusting plate is rotatably connected with the bottom support, the base is arranged below the adjusting plate, a sample table is arranged on the upper surface of the base, and the sample table is connected with the temperature control box. The sample table penetrates to the position above the surface of the adjusting plate, a sample is arranged on the sample table, an adjusting screw is arranged on the upper surface of the base and penetrates to the position above the adjusting plate, an adjusting nut is arranged on the adjusting screw, and a heat insulation glass box is arranged on one side of the upper surface of the adjusting plate. A rechargeable battery, an angle display and a laser displacement sensor are arranged in the heat insulation glass box; according to the structure, an independent heat insulation glass box is adopted, a laser hole and a heat insulation film are arranged, and the heat insulation film is used for reducing errors, caused by refraction, of a laser beam penetrating through the high-temperature-resistant heat insulation glass box on the sample placement position and deformation data of the sample.

Provided herein are kits, systems and methods for analyzing analytes from a biological sample. The system includes an upper housing configured to receive a sample substrate and a thermal element configured to control a temperature of the sample substrate. The system includes a lower housing and an alignment mechanism coupling the upper housing to the lower housing. The alignment mechanism is configured to move the upper housing, the lower housing, or both into an arrangement having an open configuration, a closed configuration, or an intermediate configuration therebetween. The thermal element is configured to cool the sample substrate.

The utility model discloses a comprehensive test box which comprises a foundation, a downwards-sunken foundation pit is arranged in the foundation, a concrete bearing base body is poured in the foundation pit, and a first buffer layer, a framework layer and a second buffer layer are arranged between the concrete bearing base body and the foundation pit. The first buffer layer, the framework layer and the second buffer layer are all of a cylindrical structure and wrap the circumferential direction and the bottom of the concrete bearing base body, and the framework layer is provided with a supporting part extending upwards in the vertical direction to form a foundation pit; the vibration table is fixedly mounted at the upper end of the concrete bearing base body through a metal base; the bottom of the test box body is provided with a butt joint window, and the butt joint window is fixedly connected to the supporting part in a sealed mode. The utility model has the beneficial effect of solving the technical problem that the connection sealing difficulty of the large-scale vibration table and the box body is large.

The present document describes methods and systems for amplifying and quantifying amplification of a nucleic acid molecule, with a polymerase chain reaction (PCR) or a loop-mediated isothermal amplification (LAMP), by irradiating, with a heating activation light beam from a continuous wave laser a biological enzymatic reaction mixture in solution comprising a nucleic acid template, a polymerase enzyme, and chemically modified nanoparticles. Quantification of the amplification is achieved by irradiating the biological enzymatic reaction mixture during an annealing and / or elongation steps with an ultraviolet (UV) light source and measuring with a photodetector a transmission change in UV light transmission.

The invention relates to a nucleic acid amplification detection module and device. The nucleic acid amplification detection module comprises a temperature adjusting mechanism and a fluorescence detection mechanism. The temperature adjusting mechanism is used for adjusting the temperature of the carrier, so that nucleic acid of a reaction sample in the carrier is amplified; the fluorescence detection mechanism and the temperature adjusting mechanism are oppositely arranged at an interval, and the fluorescence detection mechanism is used for detecting a reaction sample after nucleic acid amplification. When in use, a carrier to be subjected to fluorescence detection is placed at the interval between the temperature adjusting mechanism and the fluorescence detection mechanism, and the temperature adjusting mechanism increases and decreases the temperature of the carrier, so that a reaction sample in the carrier is heated, cooled and subjected to other reciprocating cycle operations, and nucleic acid amplification is realized. And the fluorescence detection mechanism is used for performing fluorescence detection on the nucleic acid amplification product in the carrier.

The invention discloses an optical thermostat with comprehensive vibration reduction and low-temperature in-situ displacement functions, which adopts upper and lower opposite vibration absorbers and a large-mass base to realize first-order to second-order inertial vibration absorption, and further realizes thorough decoupling with an optical platform in a suspension type non-contact manner, and the vibration transmissibility can be reduced to be less than 10%. Resonant frequencies of two systems (a sample table system and a cold head system) are designed to achieve vibration decoupling. The technical problems that in the prior art, the high-grade vibration isolation capacity is insufficient, refrigerator noise is easily coupled to a measuring light path, the low-temperature in-situ precision displacement capacity is lacked, and the contradiction between heat isolation, convenience and cost is difficult to balance can be solved. Under the support of a conventional GM refrigerator, the comprehensive requirements of ultralow basic vibration, strong decoupling of a measurement light path, low-temperature in-situ micron-sized displacement, convenient sample replacement and efficient refrigeration / thermal control are met at the same time.

The utility model discloses a high and low temperature test box, which relates to the technical field of test boxes and comprises a test box, a box cover is arranged on one side of the test box, a movable plate is arranged on the inner side of the test box, and a motor rotating component is arranged at the bottom of the test box. A movable buckle is arranged at the top of the box cover; two pull rods are symmetrically arranged at two ends of one side, close to the test box, of the box cover; a rotating disc part is arranged on the upper surface of the movable plate; the rotating disc part comprises a placement disc; the bottom of the placement disc penetrates through the movable plate to be fixedly connected with a triangular clamping pin. And the vertical projection of the triangular bayonet lock is an isosceles triangle. By means of the structure, parts of different sizes and materials can be driven to rotate, better heating is facilitated, inaccurate test results caused by uneven heating are avoided, the movable plate can be pulled out, then the rotating disc part is pulled out, the parts can be taken out conveniently, and the test efficiency is improved.

The utility model discloses a combined high and low temperature test box, which relates to the technical field of high and low temperature test boxes and comprises a box body and an electromagnet. A box door is hinged to the front side face of the box body, air inlet pipes are installed at the front end and the rear end of the left side face of the box body, exhaust grooves are evenly formed in the rear side face of the box body, two machine bases corresponding to each other left and right are arranged at the bottom end of the rear side face of the box body, the machine bases correspond to the exhaust grooves in position, and fans are placed in the machine bases. A sealing ring adheres to the front side face of the box body, the number of the electromagnets is two, the electromagnets are installed on the right side face of the interior of the box body, and a combination unit is arranged in the box body. According to the combined type high and low temperature test box, to-be-detected pieces of different specifications can be placed by adopting the placement plate which can be adjustably mounted, and meanwhile, the to-be-detected pieces can be dynamically tested by virtue of the rotatable rotating disc, so that the to-be-detected pieces can be combined and mounted according to different to-be-detected pieces, and the practicability of the test box is further improved.

This disclosure provides for devices, methods, and systems for generating a plurality of droplets within a collecting container at an extremely high rate (e.g., of at least 1 million droplets per minute, etc.), each of the plurality of droplets comprising an aqueous mixture for a digital analysis, wherein upon generation, the plurality of droplets is stabilized in position within a region of the collecting container. The inventions enable partitioning of samples for digital analyses at unprecedented rates, where readout of signals from targets within such partitions can still be achieved in accordance with various assays.

A system for clinical analysis by an analytical chip with an actuator device which, in turn, includes a computer module integrating all the signals received by the system and transforming them into analytical results, connectable through a connectivity module with a data processing module connected to an external large-scale clinical data system to generate patterns of diagnoses. A fluid drive module for the impulsion of fluids inside the analytical chip. A thermal module distinguishes thermal areas of the analytical chip. An artificial vision module of the processes is inside the analytical chip. An electronic interface communicates the sensors and actuators integrated in the analytical chip and the actuators of the actuator device with the computer module. A power management module to autonomously power the portable system inside an external container that protects all the previous modules of the actuator device and where the analytical chip is inserted.

The invention belongs to the technical field of microfluidic detection, and relates to microfluidic analysis equipment which comprises a lower shell, an outer shell, an inner lower shell, an inner upper shell, a kit mounting seat, a driving device, a magnet moving structure, a pressing structure and other core components. A kit mounting seat in the inner lower shell can be driven by a driving device to slide, a magnet moving structure drives a magnet to move along a magnet slideway of the kit to promote a micro-flow reaction, and a pressing structure presses a pressing part of the kit to assist the reaction; meanwhile, structures such as slide rail and slide block matching, motor lead screw transmission, two-dimensional code scanning, light path adjustment and temperature control are integrated, so that accurate positioning, intelligent adaptation and stable reaction environment of the kit are realized, and the detection accuracy is improved. The problems that an existing device is single in driving mode and insufficient in detection precision are solved, and the device is compact in structure, high in universality and capable of being widely applied to the fields of medical diagnosis, environment monitoring and the like.

The invention discloses an amplification chip and an amplification analysis device, and belongs to the field of nucleic acid detection, the amplification chip comprises a chip main body provided with a flow channel, the amplification chip also comprises a temperature control assembly, the temperature control assembly comprises at least one heating member, the at least one heating member heats a part of the flow channel, so that the flow channel forms at least two areas with different temperatures, and the heating member is used for heating the flow channel. The reagent reciprocates in two regions with different temperatures, so that the reaction time of the reagent is shortened, and the detection sensitivity of the amplification chip is improved.

A detection chip, a method for manufacturing a detection chip, a method for operating a detection chip, and a reaction system are disclosed. The detection chip includes a first substrate, a micro-cavity definition layer, and a heating electrode. The micro-cavity definition layer defines a plurality of micro-reaction chambers. The heating electrode is configured to release heat after being energized. The heating electrode includes a first electrode portion and at least one second electrode portion. Orthographic projections of the plurality of micro-reaction chambers on the first substrate are within an orthographic projection of the first electrode portion on the first substrate, the orthographic projections of the plurality of micro-reaction chambers on the first substrate do not overlap with an orthographic projection of the second electrode portion on the first substrate, and a resistance value of the first electrode portion is greater than a resistance value of the second electrode portion.

A thermopneumatic interface includes one or more pneumatic inlet ports in fluid communication with one or more pneumatic outlet ports and a cooling loop extending through the thermopneumatic interface. The cooling loop is configured to maintain the thermopneumatic interface at a baseline temperature. The one or more pneumatic outlet ports are configured to contact a surface of a microfluidic chip. Each pneumatic inlet port is configured to receive a change in pressure and provide the change in pressure to a corresponding pneumatic outlet port. The thermopneumatic interface is configured to maintain the microfluidic chip at the baseline temperature.

The utility model discloses an explosion-proof high and low temperature test chamber, which comprises a fresh air fan, a stirring fan and a strong exhaust fan, and further comprises a temperature control module used for controlling the temperature in the chamber of the test chamber; the humidity control module is used for controlling the humidity in the cabin; and the sampling module is used for sampling and detecting gas in the cabin. The oil temperature heat exchange mode is adopted, and a heat source is arranged outside the anti-explosion area, so that the temperature can be accurately controlled, the anti-explosion effect can be ensured, and the application of an anti-explosion scene is realized; by adopting a sampling mode of condensing and then analyzing, not only is the real-time monitoring of the state of the gas in the cabin in a high-temperature state realized, but also the safety is greatly improved.

The invention relates to the field of constant-temperature simulation boxes, in particular to a constant-temperature simulation box with circulating airflow, which comprises an outer box body and an inner box body, the inner box body is arranged in the outer box body, a mounting box and a speed regulation part are arranged in the inner box body, a fan is arranged in the mounting box, and the mounting box and the speed regulation part are connected through a communicating pipe. Wind power is provided for the speed regulating part through the mounting box; the speed adjusting piece comprises a fixing plate and a nozzle, and a plurality of ventilation holes are formed in the fixing plate. By designing a multi-stage adjustable speed regulation part structure and cooperating with the first adjusting head and the second adjusting head which are driven by the electric telescopic rod, automatic grading regulation and control of the airflow velocity are achieved, the air outlet hole diameter can be flexibly switched according to the characteristics of a test sample, high-speed direct blowing airflow can be provided for impact-resistant and non-thermosensitive samples, the heat exchange efficiency is improved, and the heat exchange efficiency is improved. The impact damage to fragile and thermosensitive samples caused by high-speed airflow can be avoided, and the test adaptation capability of equipment to samples with different characteristics is improved.

The utility model provides an electric heating jacket of avoiding corrosion, relates to the electric heating jacket field, including: heating base, heating cavity sleeve and flask, the lower end and outer side surface of flask attach heating base and heating cavity sleeve, the upper end of heating cavity sleeve is screwed with adjusting stud through fixed plate, the adjusting stud is connected with the hydraulic block of resistance through linking plate; a liquid guide cavity is formed in the upper end of the liquid blocking pressing block, an adsorption cotton block is bonded to the inner groove face of the liquid blocking pressing block, and the liquid blocking pressing block is in threaded connection with a liquid storage bottle through a mounting ring. The electric heating jacket solves the problem that power transmission is easily affected if a power supply connecting wire of the electric heating jacket is corroded by overflowing liquid in the prior art.

The present disclosure relates to a system for a test. More particularly, the present disclosure relates to a continuous loadable module-typed system for a test, a computer readable storage medium containing instructions to configure a processor to enable a continuous loadable module-typed system for a test, and a method for testing a sample. The exemplary embodiment of the presently disclosed system may be configured to support (i) single tests, (ii) batch tests, (iii) syndromic tests and / or (iv) combination tests. In addition, the exemplary embodiment of the presently disclosed system automatically processes and tests samples based on identification information, without requiring the user to classify and load the samples according to test type.

The utility model relates to the technical field of blood preservation, in particular to a stable preservation liquid device for preserving plasma free DNA for a long time, which comprises a preservation liquid device main body, the upper surface of the preservation liquid device main body is fixedly connected with a supporting material receiving shell, and the inner ring surface of the supporting material receiving shell is fixedly connected with a mounting block. And an extended threaded rod is inserted into the surface of the inner ring of the mounting block in a limiting manner. According to the stable preserving fluid equipment for preserving plasma free DNA for a long time, a preserving test tube can be clamped through a fixing plate, the temperature can be adjusted after ice blocks are added into a supporting material collecting shell, and after the temperature is adjusted, a pull handle needs to be pulled, so that the preserving fluid equipment can be used for preserving plasma free DNA stably. And then a user can take down the piston from the supporting material collecting shell, so that ice blocks in the supporting material collecting shell can be replaced, and the preserving fluid equipment can be conveniently transferred to a site through a plurality of universal wheels fixedly connected to the surface of the bottom of the preserving fluid equipment main body and an operation handrail.

The PCR plate according to the present invention includes: a body portion having one or more reaction wells; an insertion portion extending from the body portion, inserted into a nucleic acid extraction cartridge, and having an injection port into which a nucleic acid solution is injected; a flow path portion allowing the nucleic acid solution to flow from the injection port to the reaction wells; and a blocking portion attached to the body portion for blocking backflow of the nucleic acid solution from the reaction wells to the flow path portion side.

The invention discloses a simulated ultralow temperature environment experiment system, and belongs to the technical field of environment simulation and low temperature experiments, the simulated ultralow temperature environment experiment system comprises an environment simulation tank body, a heat exchange unit and a liquid nitrogen supply unit, the interior of the environment simulation tank body is an experiment space needing refrigeration, and the heat exchange unit is located in the environment simulation tank body; the liquid nitrogen supply unit is used for providing liquid nitrogen, and the output end of the liquid nitrogen supply unit is used for communicating with a refrigerant inlet of the heat exchange unit. The experiment system runs only by depending on a single cold source of liquid nitrogen, the running energy consumption is remarkably reduced, the size and shape of the environment simulation tank body can be flexibly designed and selected according to experiment requirements, the application scene is greatly expanded, the cold source is continuously supplied to the heat exchange unit arranged in the environment simulation tank body through the liquid nitrogen supply unit, and the experiment efficiency is improved. A stable and uniform ultralow-temperature gas phase environment can be created and maintained in the tank body, and a reliable guarantee is provided for an experiment.

The present disclosure relates to an optical signal detection device for analyzing a sample in a reaction vessel provided in a thermal cycler. The optical signal detection device comprises: a light source unit including a light source for generating an excitation light; a body portion coupled to the light source unit and having a plurality of passages formed therethrough; and an emission light detector provided at a side of the body portion and detects emission light emitted from the sample. According to the present disclosure, crosstalk of an optical signal generated in a sample is minimized to accurately and quickly detect the optical signal, maintenance and replacement of a beamsplitter are facilitated, and a plurality of lenses and filters may be accurately and easily arranged, fixed, or replaced.