The present invention relates to an
osmotic pump controlled-release tablet of an
insoluble drug and a preparation method therefor. The
osmotic pump controlled-release tablet comprises a tablet core, a semi-permeable membrane
coating and a
drug-release hole, wherein the tablet core comprises a
solid dispersion of the
insoluble drug and a
penetration enhancer, the
solid dispersion of the
insoluble drug comprises the insoluble
drug and a carrier, the insoluble
drug is selected from nicardipine,
nifedipine and
felodipine and pharmaceutically acceptable salts thereof, and the carrier is selected from organic acids. Compared with the prior art, the drug
solubility of the
osmotic pump controlled-release tablet of the insoluble drug of the present invention is greatly improved, a large amount of penetration enhancers or other excipients do not need to be used in the tablet core, the drug-loading capacity is improved, and the tablet core is not too large; the degree of release
in vivo is greatly improved; and the preparation process is simple, has low requirements for equipment and a low cost, and facilitates industrialized production.