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7246results about "Compound screening" patented technology
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Droplet Libraries
Owner:BIO RAD LAB INC
Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
InactiveUS20100137163A1Material nanotechnologyCompound screeningHigh-Throughput Screening AssaysEmulsion
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
Owner:BIO RAD LAB INC
Artificial antigen presenting cells and methods of use thereof
InactiveUS20020131960A1Palliating their conditionReduce riskBiocideCompound screeningEpitopeAccessory molecule
The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.
Owner:MEMORIAL SLOAN KETTERING CANCER CENT
c-Met kinase binding proteins
InactiveUS20060008844A1Stimulate and inhibit activityCompound screeningPeptide librariesKinase bindingC-Met
Owner:AMGEN MOUNTAIN VIEW
Compartmentalised screening by microfluidic control
InactiveUS20050221339A1Rapid and high-throughput screeningLow costCompound screeningSequential/parallel process reactionsCompound (substance)Drug development
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Polypeptide variants with altered effector function
InactiveUS20060067930A1High affinity bindingWeaker binding affinityCompound screeningNervous disorderEffector functionsMolecular biology
The invention provides polypeptides having IgG Fc regions with amino acid modifications that result in the polypeptides exhibiting altered Fc effector functions.
Owner:GENENTECH INC
Imide-based modulators of proteolysis and associated methods of use
The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and / or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation / inhibition of targeted polypeptides of nearly any type.
Owner:ARVINAS OPERATIONS INC
Compartmentalised screening by microfluidic control
InactiveUS20070092914A1Rapid and high-throughput screeningLow costCompound screeningSequential/parallel process reactionsCompound (substance)Drug development
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
InactiveUS20110111406A1Pharmacokinetics of the antigen-binding molecule can be improvedGood effectSsRNA viruses negative-senseCompound screeningHalf-lifeAntigen binding
Owner:CHUGAI PHARMA CO LTD
Cell flow apparatus and method for real-time of cellular responses
InactiveUS6280967B1Quick filterIncrease the number ofBioreactor/fermenter combinationsCompound screeningMeasurement testCell type
Owner:CAPLIPER LIFE SCI INC
EGFR mutations
Owner:GENENTECH INC
Cell flow apparatus and method for real-time measurements of patient cellular responses
InactiveUS6558916B2Quick filterIncrease the number ofCompound screeningBioreactor/fermenter combinationsTest agentBiology
Owner:CAPLIPER LIFE SCI INC
Plant extracts and dermatological uses thereof
InactiveUS20070122492A1Good for healthGood lookingBiocideCompound screeningMatrix metalloproteasesSkin lines
Owner:BIOPHARMACOPAE DESIGN INT
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
InactiveUS20070254295A1Eliminate side effectsCompound screeningApoptosis detectionAbnormal tissue growthSide effect
Owner:SOC DES PROD NESTLE SA
Methods for treating diabetic neuropathy
InactiveUS7030146B2Quick filterReduce the amount requiredCompound screeningBiocideInternal medicinePyridoxamine
Owner:UNIVERSITY OF SOUTH CAROLINA +1
Abeta 42 lowering agents
InactiveUS20020128319A1Prevent and delay and reverse progressionLower Level RequirementsCompounds screening/testingCompound screeningRegimenCholinesterase inhibition
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an A.beta..sub.42 lowering agent to a mammal under conditions in which levels of A.beta..sub.42 are selectively reduced, levels of A.beta..sub.38 are increased, and levels of A.beta..sub.40 are unchanged. The invention provides methods and materials for developing and identifying A.beta..sub.42 lowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of A.beta..sub.42 lowering agents and antioxidants, A.beta..sub.42 lowering agents and non-selective secretase inhibitors, as well as A.beta..sub.42 lowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing A.beta..sub.42 lowering agents, antioxidants, non-selective secretase inhibitors, and / or acetylcholinesterase inhibitors as well as instructions related to dose regimens for A.beta..sub.42 lowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.
Owner:RGT UNIV OF CALIFORNIA
Indole derivatives as CFTR modulators
Owner:VERTEX PHARMA INC
Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues
InactiveUS6881825B1Reduce deliveryFacilitating uptakeCompound screeningApoptosis detectionIn vivoCell type
The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of the peptides, and methods of use for the peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro.
Owner:UNIVERSITY OF PITTSBURGH
Advanced drug development and manufacturing
X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
Owner:RGT UNIV OF CALIFORNIA
Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators
InactiveUS20050095246A1Improve efficacyStrong specificityCompound screeningNervous disorderNervous systemNeurodegeneration
Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.
Owner:WARSAW ORTHOPEDIC INC +1
High throughput processing system and method of using
Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
Owner:NOVARTIS AG
Point-of-care fluidic systems and uses thereof
ActiveUS20060264782A1Simplify laborFacilitate high throughput point-of-care testingBioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careBiological fluid
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
Owner:LABRADOR DIAGNOSTICS LLC
Modulators of ATP-binding cassette transporters
Owner:VERTEX PHARMA INC
Methods and products for enhancing immune responses using imidazoquinoline compounds
InactiveUS20060188913A1Good curative effectReduce doseCompound screeningApoptosis detectionTime scheduleDisease
The invention involves administration of an imidazoquinoline agent in combination with another therapeutic agent. The combination of drugs may be administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs. The combinations can be used to enhance ADCC, stimulate immune responses and / or patient and treat certain disorders.
Owner:COLEY PHARM GRP INC +2
Anti-IL-6 Receptor Antibody
InactiveUS20110245473A1Enhanced antigen-neutralizing activity and pharmacokineticsGood treatment effectCompound screeningApoptosis detectionHigh concentrationHinge region
Owner:CHUGAI PHARMA CO LTD
Load-controlled device for a patterned skin incision
InactiveUS7160313B2Minimize traumaReduce introductionCompound screeningApoptosis detectionEngineeringSkin incision
Owner:HELENA LAB
Inhibitors of Human EZH2 and Methods of Use Thereof
Owner:EPIZYME
Indole derivatives as CFTR modulators
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Owner:VERTEX PHARMA INC
Antagonizing interleukin-21 receptor activity
InactiveUS20060039902A1Reduce riskSufficient amountCompounds screening/testingCompound screeningWhite blood cellFibrosis
Methods and compositions for inhibiting interleukin-21 (IL-21) / IL-21 receptor (MU-1) activity using antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed. IL-21 / IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating, ameliorating or preventing autoimmune or inflammatory disorders, including, e.g., inflammatory bowel disease (IBD), rheumatoid arthritis (RA), transplant / graft rejection, psoriasis, asthma, fibrosis, and systemic lupus erythematosus (SLE).
Owner:WYETH LLC
Prodrugs of modulators of ABC transporters
InactiveUS20090105272A1Good water solubilityImprove bioavailabilityAntibacterial agentsCompound screeningDiseaseStereochemistry
Owner:VERTEX PHARMA INC
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