101results about How to "Improve bioavailability" patented technology

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

The application provides a cold-dissolved liver-protecting medicinal tea and a preparation method and application thereof. The preparation raw materials of the cold-dissolved liver-protecting medicinal tea include green tea, rattan tea, ginseng, lotus leaves, mulberries and hawthorn. The preparation method comprises the steps of grouping extraction and spray drying of the preparation raw materials. The air inlet temperature of the spray drying is 130-150 DEG C, and the air outlet temperature is 75-85 DEG C. The grouping extraction comprises jointly extracting the ginseng, mulberries and hawthorn, and jointly extracting the green tea, rattan tea and lotus leaves in the presence of cyclodextrin. The cyclodextrin comprises one or more of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. The cold-dissolved liver-protecting medicinal tea is derived from natural plants, has a simple formula, is safe and effective, is convenient to use, and can retain active ingredients to the greatest extent.

This invention relates to the fields of pesticide formulations and pesticide pest control, specifically to a composite nano-slow-release suspension of emamectin benzoate and chlorantraniliprole, its preparation, and application. The nano-slow-release suspension comprises emamectin benzoate, chlorantraniliprole, a nanocarrier, a wetting agent, a dispersant, a synergist, a thickener, an antifoaming agent, an antifreeze, a preservative, and water. The nanocarrier is an NX-CMCS & MOF composite nanocarrier. Spraying this composite nano-pesticide onto crops improves the adhesion and penetration of the pesticide on leaves, enhances its resistance to rain washout, and effectively kills major crop pests such as bollworms, diamondback moths, cowpea thrips, and rice planthoppers. Compared with traditional pesticide formulations, it has a significant effect of reducing dosage and increasing efficacy, and has broad application prospects in the field of agricultural pest control and promoting green agriculture.

The present application relates to a crystal form of a compound of formula (I) and a preparation method and application thereof. Specifically, the present application provides a crystal form of a compound of formula (I), which has good stability, good drug efficacy, and good safety, and can be used for preparing a drug for treating or preventing feline transmissible enteric disease virus infection or coronavirus infection caused diseases.

The present invention provides a high-protein bio-fermented aquatic feed and a preparation method thereof. The aquatic feed comprises the following raw materials in parts by weight: 20-30 parts of imported fish meal, 10-15 parts of compound minerals, 5-10 parts of bioactive peptides, 5-10 parts of lysine, 5-10 parts of compound trace elements, 3-8 parts of compound vitamins, 3-6 parts of herbal extracts, 2-5 parts of compound probiotics, 2-4 parts of immune polysaccharides, and 1-3 parts of compound enzymes; the herbal extracts are prepared by fermenting astragalus membranaceus, isatis root, liquorice root, calotropis gigantea, ventilago leiocarpa benth, clove, rhizoma chuanxiong, and galangal officinale. By organically integrating imported fish meal, astaxanthin-peptide chelate, herbal extracts, compound immune polysaccharides, compound probiotics and various nutrients, the present invention realizes the synergistic effect of "promoting feeding - enhancing digestion - strengthening liver and gall - enhancing immunity - resisting stress - inhibiting bacteria - stabilizing water quality", significantly improves the growth rate, survival rate and comprehensive breeding benefit of crustacean aquatic animals, and has good economic value and application prospect.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present application relates to the technical field of feed additive, and discloses a lactation-promoting functional feed for lactating sows containing high-efficiency plant lactogenic factors, which is made of the following raw materials: sodium-based montmorillonite, fenugreek extract, motherwort extract, ion intensity regulator, lysophosphatidylcholine, tributyl citrate and high-purity silicon dioxide, and is prepared through the following steps: mixing and drying sodium-based montmorillonite with the ion intensity regulator to prepare a regulation carrier; adding fenugreek and motherwort extract and mixing them by strong shearing to form an active core; atomizing and spraying a mixture of lysophosphatidylcholine and tributyl citrate on the surface of the core to form a functional layer; and finally adding high-purity silicon dioxide and mixing uniformly to obtain the feed. Through the construction of the structure with ion-pretreated montmorillonite as the core and the functional layer as the shell, the present application realizes the protection, sustained release and efficient absorption of the active ingredients, and improves the bioavailability.

This invention discloses a Tibetan bath composition compound and its preparation method, relating to the field of daily chemical products technology. The Tibetan bath composition compound consists of a ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder, Bacillus subtilis, Tibetan medicine composition, starch, anhydrous citric acid, sodium bicarbonate, calcium citrate, crospovidone, and magnesium stearate. Bacillus subtilis is used to ferment the ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder to obtain a fermentation-modified porous carrier, which is then loaded with the Tibetan medicine composition to form a Tibetan medicine inclusion powder. This not only achieves efficient drug delivery through a triple mechanism of biomodification, metabolite synergy, and structural optimization, but also forms a quaternary system with Terminalia chebula. The effervescent effect also enhances the penetration of Tibetan medicine components, which is beneficial for better exerting the antibacterial and anti-inflammatory effects of active substances, and significantly improving fungal infections and eczema-related skin problems.

The present application relates to the field of pharmaceutical preparations, in particular to a long-acting eye composite preparation for improving the symptoms of blepharitis. The preparation comprises a combination of two active ingredients in a therapeutically effective amount, and one or more ion-sensitive polymers or their complex systems, which are used to treat the symptoms of blepharitis caused by Demodex through a special double-cavity drug delivery bottle. By using a specific ion gel matrix concentration and regulating the viscosity of the drug solution before it reaches the eye, the limitations of traditional eye preparations are overcome, the retention time of the drug in the eye is prolonged, the bioavailability is improved, the probability of adverse events is reduced, and the medication compliance is increased.

The present application relates to a rare ginsenoside composition and a method and application thereof, wherein the ginsenoside composition comprises 0.02-0.1 mg / mL of S-Rg3, 0.009-0.029 mg / mL of R-Rg3, 0.087-0.245 mg / mL of Rg5 and 0.013-0.044 mg / mL of CK. The rare ginsenoside is prepared by fermentation, which comprises the following steps: step-by-step fermentation with yeast and lactic acid bacteria. Through the step-by-step fermentation method, the inherent ginsenoside is converted into rare ginsenoside, and 17 kinds of rare ginsenosides, including S-Rg2, R-Rg2, F1, F4, Rk3, F2, Rh4, S-Rg3, R-Rg3, PPT, Rg5, CK, S-Rh2, R-Rh2, Rk2, Rh3 and PPD, are obtained. The bioactivity of the fermented ginseng is higher, and the fermented ginseng can be applied to the food, medicine, health food and skin care product industries.

This invention discloses a strain of *Lactobacillus plantarum* CCFM1487 and its prepared metagener for lowering lipids and alleviating fatty liver, as well as its application in converting cassiaside. It belongs to the fields of microbial technology and food and health product technology. This strain can efficiently convert cassiaside into cassiaside aglycone. The core of this invention lies in providing a metagener prepared from this strain through fermentation and inactivation treatment. Experiments in a high-fat diet mouse model have demonstrated that it significantly reduces serum total cholesterol and triglyceride levels, and can alleviate hepatic lipid deposition and improve hepatic steatosis. Based on this metagener, foods, medicines, or health products can be developed for the prevention and / or adjuvant treatment of metabolic disorders such as hyperlipidemia and non-alcoholic fatty liver disease, possessing significant application value.

The present application relates to the field of feed additive, and discloses a feed additive, a preparation method and application thereof.The feed additive contains astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and a carrier.The preparation method comprises the following steps: mixing astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and the carrier.The feed additive can significantly improve the stress resistance, immunity, antioxidant capacity and disease resistance of aquatic animals, and has significant economic benefits.

The application provides a sulfur-oxidizing bacteria-mediated carbon-free autotrophic denitrification water treatment method, and the high-performance sulfur-oxidizing bacteria with a polysulfide yield of 35%-42% is prepared through the dual-stress gradient domestication of the mass proportion of elemental sulfur in the sulfur source and the pH of the system; the high-activity bacterial suspension is prepared through centrifugal washing and buffer resuspension; the partitioned fluidized bed reactor is used, the compound sulfur source of elemental sulfur and sodium sulfide with nine waters is proportionally controlled in stages, and under the condition of no organic carbon source, the efficient autotrophic denitrification of the nitrogen-containing wastewater is realized. The denitrification efficiency is high, the operation stability is strong, no organic carbon source needs to be added, the simultaneous removal of multiple pollutants such as total phosphorus and suspended solids can be realized, the effluent quality can stably meet the high-standard discharge requirements, and the application is suitable for the advanced denitrification treatment of tail water of urban sewage treatment plants and industrial low-carbon-nitrogen-ratio wastewater.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

This invention discloses a method for enhancing the antibacterial activity of Propionibacterium freudenreichii subsp. shermanii metabolites by adding a surfactant to a culture medium. The method uses Propionibacterium freudenreichii subsp. shermanii NBRC No. 12426 as the experimental strain and Pichia anomala SICC 2.894 as the indicator strain. A surfactant is added to the fermentation medium to enhance the antibacterial activity of the metabolites of Propionibacterium freudenreichii subsp. shermanii against the indicator strain Pichia anomala. Based on the culture conditions and method of Propionibacterium freudenreichii subsp. shermanii in this invention, the optimal concentration of the surfactant Tween-80 is selected as 0.3%, which significantly enhances the antibacterial activity of the metabolites of Propionibacterium freudenreichii subsp. shermanii.

This invention discloses a method for the biological drying of sludge, comprising the following steps: baking biomass materials, mixing the resulting baked product with sludge, biochar materials, and a conditioner for biological drying, thereby completing the sludge drying process. In this invention, by biologically drying the mixture of baked product, sludge, biochar materials, and conditioner, not only can the self-generated heat within the system be used to effectively dewater the sludge in a very short time, but the bioavailability of the microbial carbon source can also be improved, effectively reducing the generation of polluting gases. This method can effectively reduce the emission of polluting gases while achieving rapid dewatering. It has advantages such as simple process, low treatment cost, low energy consumption, high drying efficiency, good dewatering effect, low polluting gas production, and low content of toxic and harmful components in the dried product. It can solve the problems of biomass resource waste and pollution, achieve sludge reduction and resource utilization, and has high returns and good application prospects.

The application discloses an olmesartan medoxomil and amlodipine besylate pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines. The olmesartan medoxomil and amlodipine besylate pharmaceutical composition takes olmesartan medoxomil and amlodipine besylate as active ingredients, and is prepared into antihypertensive tablets by being matched with a disintegrant, a filler and a lubricant; wherein the filler is a mixture of pre-gelatinized starch and a co-processed product of microcrystalline cellulose and colloidal silicon dioxide. The preparation method adopts a direct compression process, and sequentially comprises the steps of mixing, whole-granulating, twice mixing, lubricating, tabletting and stomach-soluble film coating, and is simple in process and suitable for industrialized scale-up production. The application effectively solves the problem of low dissolution rate of the existing olmesartan medoxomil and amlodipine besylate tablets, and the prepared tablets have the advantages of high dissolution rate, similar dissolution curve to commercial preparations, high bioavailability, stable quality and good clinical application value.

The application belongs to the technical field of biological medicine, and more particularly relates to nanoparticles TK-PSBs / CBD@Met, a preparation method therefor and application thereof. The nanoparticles TK-PSBs / CBD@Met are nanoparticles formed by wrapping cannabidiol and metformin with thione-modified lung surfactant biomimetic liposomes. In vitro experiments have confirmed that the nanoparticles TK-PSBs / CBD@Met can effectively inhibit the fibrosis process of BEAS-2B cells induced by silicon dioxide. Animal experiments have shown that the nanoparticles TK-PSBs / CBD@Met can significantly improve the damage to the lung tissue structure and abnormal deposition of collagen caused by SiO2 exposure, and alleviate the pathological progression of silicosis fibrosis.

The application discloses a compound for targeting IRAK4 protein degradation and application thereof. The compound is a compound shown in formula I, and formula I is T-L-E. In formula I, T is selected from groups shown in formulae T-1 and T-2; E is selected from groups shown in formulae E-1, E-2 and E-3; and L is a linking group with a length of 0-15 atoms. The compound adopts a double-target molecule structure, wherein one end of the molecule is targeted to combine with E3 ligase, and the other end of the molecule is targeted to combine with a target protein (IRAK4 protein) to be degraded. The two ends of the structure are connected through a chain (linker) to form a complete compound molecule. The molecule can reduce the IRAK4 protein level, so that the kinase catalytic function and the scaffold function of the IRAK4 protein are lost at the same time, and a new direction is provided for the treatment of IRAK4 related diseases.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

This invention provides a microemulsion gel of traditional Chinese medicine (TCM) compound essential oils, its preparation method, and its application, relating to the technical field of TCM compound essential oil preparations. Following TCM theory and based on the principle of syndrome differentiation and treatment, this invention yields a microemulsion gel of TCM compound essential oils composed of Bupleurum chinense essential oil, Citrus reticulata peel essential oil, Ligusticum chuanxiong essential oil, Murraya paniculata essential oil, and Nardostachys chinensis essential oil, which has the functions of soothing the liver and regulating qi, promoting blood circulation and relieving pain. Based on single-factor experiments, this invention uses response surface methodology to optimize the formulation of the TCM compound essential oil microemulsion gel, ultimately obtaining a uniform, stable, and easily spreadable microemulsion gel. The TCM compound essential oil microemulsion gel of this invention can effectively improve depressive-like behavior in mice under chronic unpredictable stress and reduce the levels of inflammatory factors in the CUMS mouse model, effectively improving the bioavailability of active ingredients in plant essential oils. This invention provides reference and guidance for the development of new dosage forms for the prevention and treatment of depression and the application of TCM essential oils.

This invention belongs to the field of pharmaceutical technology for the treatment and prevention of oral diseases, and particularly relates to a porphyrin and ferrocene derivative, nanoparticles, preparation methods, and applications of synergistic photothermal and acoustic therapy for oral diseases. The porphyrin and ferrocene derivative are formed by organically combining tetraaminophenylporphyrin and diformaldehyde ferrocene through imine dynamic covalent bonds. This invention, through innovative raw material coupling methods and functional integration design, synergistically achieves PTT-SDT dual therapy, providing a new and superior technical solution for precise, efficient, and low-drug-resistance treatment of deep oral bacterial-fungal biofilm infections.

This invention discloses an apple pomace ESP-Zein-lutein composite nanoparticle delivery system and its preparation method, belonging to the field of functional food carrier and bioactive substance delivery technology. ESP is purified from apple pomace through hot water extraction, TCA deproteinization, and dialysis decolorization. Combined with antisolvent precipitation and electrostatic adsorption technology, composite nanoparticles with uniform particle size and high stability are prepared. The optimized ratio is Zein:ESP:lutein = 1:0.4:0.08. In this system, Zein and lutein form a hydrophobic core, and ESP forms a shell through hydrogen bonding and electrostatic interactions. The lutein encapsulation rate reaches 90.5%, significantly higher than the 54.7% of the single Zein system, making it suitable for targeted delivery of functional food additives, antioxidants, and eye health-related products.

The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

This invention relates to the field of edible leaf grass powder processing technology, specifically to an edible leaf grass powder and processing technology, including the following steps: S100: Fresh tender stems and leaves of edible leaf grass are washed and sterilized, and then subjected to blanching, enzyme inactivation, drying, and pulverization to obtain fresh edible leaf grass powder; S200: The fresh edible leaf grass powder is mixed with water according to a set material-liquid ratio, alkali solution is added for purification, and a first solid-liquid separation is performed to obtain the supernatant; then acid solution is added to the supernatant to adjust to the isoelectric point for precipitation, and a second solid-liquid separation is performed to obtain protein precipitate, which is then washed with water to remove acid. This invention effectively overcomes the problems of enzymatic browning and protein thermal denaturation that are prone to occur in traditional edible leaf grass processing by constructing a technical system of precise blanching and enzyme inactivation combined with gentle extraction and purification; combined with microfiltration membrane physical impurity removal and a specific anti-sticking spray drying formula, the purity of the target product and the industrial powder collection rate are greatly improved.

The present application relates to a kind of tetrahydroxy bile acid pharmaceutical composition and its preparation method and application.The present application provides a kind of pharmaceutical composition, it includes 100 weight parts of compound shown in formula I and 300~900 weight parts of saccharide.The present application also provides the use of the pharmaceutical composition in the preparation of drug for treating PFIC.The pharmaceutical composition of the present application can improve dose accuracy, solve the problem of poor taste of bile acid compound, easy to swallow, can improve the compliance of children drug.The pharmaceutical composition of the present application has good stability, easy to transport and store.In addition, the pharmaceutical composition of the present application realizes the stability of treatment effect under different doses, easy to accurately dose children according to body weight, while having good bioavailability, can realize good absorption and utilization in vivo.

This invention discloses a method for preparing Polygonatum sibiricum enzyme liquid, belonging to the field of bio-fermentation technology. The method includes: gradient permeation activation treatment of Polygonatum sibiricum, including negative pressure pulsating permeation and reduced pressure concentration under inert gas protection; preparation and co-inoculation of a composite strain of Lactobacillus plantarum and Saccharomyces cerevisiae propagated in a stepwise sequential manner; multi-stage temperature and pressure-coupled fermentation, including pressurized microaerobic primary fermentation and high-temperature static incubation for enhanced conversion; targeted induction of enzymatic hydrolysis and low-temperature maturation; and in-situ aseptic filling. This invention does not add any other ingredients throughout the entire process. Through a series of original, interrelated process steps and precise parameter control, it solves the technical problem of efficiently converting a single Polygonatum sibiricum raw material into a high-quality enzyme liquid, ultimately producing a pure Polygonatum sibiricum enzyme liquid with high active substance content, mellow taste, and excellent stability.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

This invention, entitled "A Low-Loss β-Carotene Microcapsule and Its Preparation Method," belongs to the field of microcapsule preparation technology. The technical problem to be solved is that during high-temperature melting, particulate all-trans β-carotene transforms into a molecular state, but this process generates a large number of cis isomers and results in significant content loss. Furthermore, the particle size and dispersibility of the particulate β-carotene prepared by grinding are still unsatisfactory, leading to low bioavailability and poor application effects. The key point of this technical solution is to prepare high all-trans molecular β-carotene microcapsules through a specific combination of treatments. This reduces content loss and cis-trans isomerization during the transformation of β-carotene from particulate to molecular state, thereby significantly improving the bioavailability of β-carotene microcapsules. Moreover, the preparation process is simple, cost-controllable, and suitable for large-scale industrial production.

The invention belongs to the field of biological medicine, and particularly relates to a 5 'UTR sequence and application thereof. The technical problem to be solved by the invention is to improve the expression efficiency of mRNA drugs. The main technical scheme of the invention is as follows: two 5 'UTR sequences, which are SEQ ID NO: 1 and SEQ ID NO: 2, are provided; and a nucleic acid molecule comprising the 5 'UTR sequence. Compared with a 5 'UTR sequence optimized in the nature, the mRNA constructed by the 5' UTR has the advantages that the expression efficiency of a target gene is obviously improved; the preparation method is beneficial to reducing the administration dosage and administration frequency of the mRNA drug, reducing the cost of the mRNA drug and reducing the risk of adverse reaction after administration, and has a good application prospect in the industrial production of the mRNA drug.