965results about How to "Improve bioavailability" patented technology

The invention discloses pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles as well as preparation and application thereof, and relates to the technical field of pharmaceutical preparations. Inspired by compatibility and solubilization of traditional Chinese medicines, the pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles (AB4-OA NPs) are prepared by taking natural active components, namely micromolecular pulsatilla saponin B4 and oleanolic acid, as raw materials; the oleanolic acid has the effects of promoting dissolution and resisting inflammation, the water solubility of the oleanolic acid is improved, the bioavailability is improved, and the anti-inflammatory effect of the oleanolic acid is enhanced. Experimental results show that the AB4-OA NPs can effectively improve the dissolution rate of the oleanolic acid, so that the bioavailability of the oleanolic acid is effectively improved, meanwhile, the AB4-OA NPs has a better anti-inflammatory effect, and the effect is better than that of a single drug with the same dosage. In addition, the synthetic preparation method is simple and convenient, has the advantages of nano-scale drugs, realizes auxiliary-material-free pure drug self-delivery, and improves the delivery efficiency.

The invention discloses an atorvaquone enteric-coated tablet, the preparation comprises atorvaquone, glyceryl behenate, teloxpol, a filler, an adhesive, a disintegrating agent and an enteric coating, and the particle size D90 of the atorvaquone is 30-50 [mu] m. The atorvaquone enteric-coated tablet disclosed by the invention is stable and continuous in release and high in bioavailability, can be positioned and released in intestinal tracts and reduce liver circulation, so that the occurrence of phenomena such as liver injury is reduced, the phenomena such as sticking and cracking are avoided in a tabletting process, the quality is qualified and stable, and the dissolution performance and the stability of the atorvaquone enteric-coated tablet are also ensured.

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

The invention discloses a cationic polymer-based proteolysis targeting chimera as well as preparation and application thereof, and belongs to the fields of targeting protein degradation and nanotechnology. According to the chimera, a cationic polymer is used as a connecting arm to connect a target protein ligand and an E3 ubiquitin ligase ligand to form a ternary complex, so that efficient degradation of target protein is realized. By adjusting the ligand proportion, chimeras with different degradation efficiencies can be synthesized, and accurate regulation and control are realized. The pH-responsive nano-drug obtained by hydrolyzing the targeting chimera by using the targeting protein can respond to an acidic tumor microenvironment, specifically release the chimera, and improve the targeting property and the treatment effect of the drug. Compared with the traditional PROTACs, the compound has higher bioavailability and tumor permeation effect; the preparation method of the nano-drug is simple and easy to implement, provides possibility for preparation of high-performance nano-drugs, shows potential in preparation of anti-tumor cell drugs, provides new thoughts and methods for tumor treatment, and has important clinical application value.

The invention discloses biphase gel loaded with natural antioxidants as well as a preparation method and application of the biphase gel. The biphase gel is obtained by mixing oil gel and hydrogel in a mass ratio of (20: 80)-(80: 20) through a physical effect, wherein the hydrogel is composed of a water-soluble natural antioxidant and a polysaccharide aqueous solution; the oleogel is composed of an oleogel agent, a fat-soluble natural antioxidant, a small molecule emulsifier and edible oil. According to the present invention, the water-soluble nutrients are loaded in the hydrogel, and the fat-soluble nutrients are loaded in the oil gel to prepare different types of the two-phase gel nutrient delivery systems simultaneously loading the hydrophilic and hydrophobic natural antioxidants so as to effectively improve the steady-state protection effect and the bioavailability of the nutrients.

The invention relates to the technical field of pharmaceutical preparations, in particular to an upatinib oral solution as well as a preparation method and application thereof. The oral upatinib solution is prepared from the following components in percentage by weight: 0.1%-1.5% of upatinib, 1%-20% of hydroxypropyl beta-cyclodextrin, 0.5%-5% of a flavoring agent and the balance of water, wherein the oral upatinib solution is prepared from the following components in percentage by weight: 0.1%-1.5% of upatinib, 1%-20% of hydroxypropyl beta-cyclodextrin, 0.5%-5% of a flavoring agent and the balance of water; the degree of substitution of the hydroxypropyl beta-cyclodextrin is 4.0 to 5.5. The oral upatinib solution overcomes the problems of overlarge tablet diameter, poor oral compliance, low solubility in water and low bioavailability of upatinib tablets in the prior art, and has the advantages of simplicity in preparation and convenience in use.

The invention relates to the technical field of medicine, and discloses an artificial exosome and application thereof in drug delivery, the artificial exosome is prepared into an oil phase based on PLGA and DOTAP, and a water phase based on OCT4 protein and siTrim28; mixing the two phases to obtain a primary emulsion, and adding a PVA aqueous solution to obtain a double emulsion; stirring the double emulsion and volatilizing the solvent to form an emulsified solution, and centrifuging to obtain PLGA nanoparticles; the lipid mixture is prepared from lipid, DPPE-PEG2000, alpha-tocopherol and alpha-lactalbumin, and a lipid film is formed after a solvent is evaporated; the preparation method comprises the following steps: mixing PLGA nanoparticles, a lipid film and membrane protein, uniformly mixing and heating to obtain a film-coated solution, and finally extruding through a cellulose acetate film to obtain the artificial exosome. The artificial exosome disclosed by the invention combines the stability of the PLGA nanoparticles and the biocompatibility of the lipid membrane, and provides new possibility for a drug delivery system.

The invention belongs to the field of preparation of sedation maintaining agents, and particularly relates to a sedation maintaining agent administrated through oral mucosa and a preparation method of the sedation maintaining agent. Bamboo leaf polysaccharide and pigskin collagen peptide are heated and mixed with chlorogenic acid and butyl acetate under the catalytic action of lanthanum nitrate, and the obtained moisturizing adhesive has biocompatibility, can be stably adhered to oral mucosa and can promote salivary secretion of children; nanoparticles obtained through freeze spray drying are uniformly dispersed in a copolymer solution containing sodium salicylate and polyacrylate, and the obtained nervous system regulator can balance excitability of sympathetic nerves and parasympathetic nerves of children; the emotion relieving composition contains modified felwort powder obtained through esterification reaction, the modified felwort powder is mixed with a moisturizing adhesive and a nervous system regulator, and the prepared sedation maintaining medicament administrated through the oral mucosa protects oral health of children in the oral operation anesthesia process, is free of irritation, improves anxiety emotion and does not affect postoperative awakening.

The invention provides a preparation method and application of magnesium L-threonate, and belongs to the technical field of medicines. The preparation method comprises the following steps: dissolving L-ascorbic acid in water, adding magnesium hydroxide and alkaline magnesium carbonate, stirring, dropwise adding hydrogen peroxide, heating, stirring and reacting, filtering a product, purifying and concentrating by temperature-sensitive molecularly imprinted hydrogel while the product is hot, adding an ethanol water solution into a concentrated solution, standing, crystallizing, filtering, washing and drying to obtain the magnesium L-threonate. And cooling the temperature-sensitive molecularly imprinted hydrogel after adsorption to room temperature, washing and repeatedly using the temperature-sensitive molecularly imprinted hydrogel. The magnesium L-threonate is simple in preparation method, high in purity and high in yield, meanwhile, the slow-release magnesium L-threonate is prepared, and the magnesium L-threonate is low in toxicity, good in biocompatibility, large in drug loading capacity, low in economic cost and good in drug effect and has wide application prospects in preparation of anti-depression drugs.

The invention provides a complement factor B inhibitor compound, pharmaceutically acceptable salts thereof, a medicinal composition thereof and application of the complement factor B inhibitor compound in preparation of medicines related to complement factor B. The compound has a structural formula shown in a formula (I), and experimental results show that the compound has good complement factor B inhibitory activity, good in-vivo C3a level inhibition rate, bioavailability and safety. Particularly, the polypeptide has more remarkable binding capacity with target protein. # imgabs0 #

The invention discloses traditional Chinese medicine monomer self-assembled nanoparticles as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. According to the prepared traditional Chinese medicine monomer self-assembled nanoparticles, namely ginsenoside Rg1-oleanolic acid self-assembled nanoparticles, the self-assembled structural characteristics of ginsenoside Rg1 are ingeniously utilized, the superficial area of the medicine can be effectively increased, the solubility of oleanolic acid can be improved, and therefore the bioavailability of oleanolic acid is effectively improved, and the anti-inflammatory effect of the oleanolic acid is further enhanced. And compared with a physical mixed medicine with the same dosage, the effect is more remarkable. Besides, the preparation method is simple and easy to implement, not only has the advantages of nanoscale drugs, but also realizes self-delivery of pure drugs without auxiliary materials, and greatly improves the delivery efficiency of the drugs.

The invention provides a quick-release alfacalcidol soft capsule and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the preparation raw materials comprise a PLGA microsphere content containing vitamin D3 and a capsule shell liquid containing beta-cyclodextrin, the preparation method of the quick-release alfacalcidol soft capsule comprises the following steps: preparing the capsule content and the capsule shell liquid into the soft capsule by using a full-automatic soft capsule machine, shaping in cold air at the temperature of 20 DEG C and the humidity of 45%, washing pills, drying and packaging to obtain the alfacalcidol soft capsule.

The invention provides a preparation composition of a glucagon-like peptide-1 receptor agonist for nasal mucosa administration, and particularly relates to the technical field of biological medicine materials. The preparation composition mainly comprises a glucagon-like peptide-1 receptor stimulant, alkyl glycoside and phospholipid, wherein the ratio of the glucagon-like peptide-1 receptor stimulant to the alkyl glycoside to the phospholipid is (0.25-17.5): (0.25-10): (0.1-10) by mass. The active pharmaceutical ingredients in the preparation composition provided by the invention are delivered through nasal mucosa, directly enter blood circulation from an absorption part, can take effect quickly, have higher bioavailability, and improve the compliance of patients.

The invention discloses a Gegen Qinlian decoction vesicle-like nanoparticle as well as an extraction method and application thereof, and belongs to the technical field of biological medicines. The method comprises the following steps: preparing a radix puerariae qinlian decoction stock solution; placing at 4-8 DEG C for 12-15 hours to obtain a gelatinous substance; carrying out low-speed centrifugation at 4-8 DEG C, and taking supernate, so as to obtain crude extract of the vesicle-like nanoparticles of the radix puerariae, radix scutellariae and rhizoma coptidis decoction; carrying out ultracentrifugation at 4-8 DEG C, discarding the supernatant, and carrying out PBS resuspension precipitation to obtain a crude product of the vesicle-like nano-particles of the Gegen Qinlian decoction; and centrifuging 16000g at the temperature of 4-8 DEG C for 10-15 minutes, taking supernate, and filtering by using a 0.22 mu m filter membrane, so as to obtain the vesicle-like nanoparticles of the Gegen Qinlian decoction. According to the Gegen Qinlian decoction vesicle-like nanoparticles as well as the extraction method and the application thereof, the bioavailability and the targeting property of effective components in the Gegen Qinlian decoction are remarkably improved through a nanocrystallization technology, the concentration of the medicine at the ulcerative colitis part is enhanced, and the treatment effect is effectively improved.

The invention discloses a collagen microsphere ergothioneine compound, a multifunctional efficient broad-spectrum sunscreen composition containing the collagen microsphere ergothioneine compound and a preparation method, the collagen microsphere ergothioneine compound comprises III-type recombinant human collagen microspheres and ergothioneine, the mass ratio of the III-type recombinant human collagen microspheres to the ergothioneine is (0.5-2): (5-20); the compound further comprises Ectoine, and the content of the Ectoine is 15-140 times that of the III type recombinant human collagen microspheres. Through the use of the collagen microsphere ergothioneine compound, the light stability of the ergothioneine can be protected, quick and efficient permeation can be realized by carrying the ergothioneine by utilizing the extremely high permeability of the III type recombinant human collagen microspheres, and the bioavailability of the ergothioneine and the stability of the ergothioneine in a formula system of the sunscreen composition are improved; meanwhile, the sunscreen composition integrates multiple functions of high-power sunscreen, anti-inflammatory repair, blue light resistance and the like, and has very good market prospects and economic values.

The invention relates to application of an antioxidant liposome in preparation of a medicine for preventing and / or treating inner ear injury caused by active oxygen accumulation, and belongs to the field of medical technologies and biological medical materials. The antioxidant lipidosome is rutin-entrapped lipidosome, and the inner ear injury is preferably cis-platinum induced inner ear injury. The antioxidant liposome disclosed by the invention is used for inhibiting active oxygen accumulation, mitochondrial injury and cell apoptosis in cells; the compound is used for inhibiting auditory hair cell mitochondrial injury in cochlea. The antioxidant liposome disclosed by the invention can be used for effectively packaging medicines and improving the bioavailability and the stability of the medicines; the limitation of a tympanic membrane barrier and other biological barriers can be overcome, so that the medicine can effectively reach the inner ear part; precise targeted delivery of the medicine can be achieved, and it is ensured that the medicine is intensively released at the needed position.

The invention discloses an oleanolic acid / cyclodextrin metal organic framework compound and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: dissolving gamma-cyclodextrin and alkaline potassium salt in water to obtain crystallization mother liquor of a cyclodextrin metal organic framework; and then adding oleanolic acid into the crystallization mother liquor of the cyclodextrin metal organic framework for co-crystallization growth to obtain the oleanolic acid / cyclodextrin metal organic framework compound. According to the co-crystallization method provided by the invention, the oleanolic acid can be efficiently encapsulated in the cyclodextrin metal organic framework, and the solubility of the oleanolic acid is improved by 109.81 times by the prepared oleanolic acid / cyclodextrin metal organic framework compound, so that the lipid-lowering activity of the oleanolic acid is further enhanced; the compound provided by the invention has wide application potential in the aspects of preparing medicines for preventing / treating the non-alcoholic fatty liver disease and the like.

According to the nitrogen hydrochloride # imgabs0 # stine eye drops for treating allergic conjunctivitis and the preparation method of the nitrogen hydrochloride # imgabs0 # stine eye drops, the prepared eye drops can interact with the mucous layer on the surface of keratoconjunctiva by selecting specific solid lipid and a surfactant and controlling the dosage of the solid lipid and the surfactant; the retention capacity of the medicine in front of the cornea is prolonged, so that the medicine has good targeting property, the continuous release of the medicine is realized, the medication frequency can be reduced, the toxic and side effects of the medicine are reduced, the bioavailability is improved, the medication compliance of a patient is enhanced, and in the preparation and long-term storage processes, the medicine has better stability, and is suitable for popularization and application. Therefore, the problems of excessive drug due to multiple administration and poor stability of the active component nitrogen hydrochloride # imgabs1 # stine are solved.

The invention relates to the field of cosmetics, in particular to a berry composition for scalp care and a preparation method and application thereof, and the preparation method comprises the following steps: A, pretreating fruits to obtain berry freeze-dried powder; b, preparing a deep eutectic solvent; c, mixing the berry freeze-dried powder with the deep-eutectic solvent, and performing oscillation extraction to obtain a berry procyanidine crude extract; d, purifying the berry procyanidine crude extract with macroporous resin to obtain a first purified berry procyanidine product; e, removing the solvent from the first purified berry proanthocyanidins to obtain a second purified berry proanthocyanidins; and F, dissolving epicatechin, mixing the dissolved epicatechin with the second purified product of the berry procyanidine, uniformly heating in a vacuum environment, cooling after relieving the vacuum environment, mixing with amino acid hydrochloride, and preserving heat to obtain the berry extract.

The invention provides a preparation process of micromolecular cubilose peptide and a compound tablet thereof, and belongs to the technical field of protein and peptide. The preparation process of the micromolecular cubilose peptide comprises the following steps: freezing and crushing cubilose; and carrying out compound enzyme enzymolysis. The preparation method comprises the following steps: repeatedly freezing and crushing cubilose to prepare cubilose powder, adding the cubilose powder into deionized water, heating and stewing, and adding a compound enzyme formed by mixing neutral protease and flavourzyme for ultrasonic-assisted enzymolysis to obtain the micromolecular cubilose peptide, when the neutral protease and the flavourzyme are mixed according to the mass ratio of 1: (2.8-3.4) to conduct enzymolysis on the cubilose, hydrolysis can be conducted from multiple positions, smaller peptide fragments are formed, the hydrolysis degree is effectively improved, sialic acid originally combined with protein is also released along with hydrolysis of the protein, and therefore the content of sialic acid in the cubilose is increased. Therefore, the content of sialic acid in the prepared micromolecular cubilose peptide can be effectively improved.

The invention discloses an amorolfine hydrochloride liniment and a production process. The formula of the amorolfine hydrochloride liniment comprises amorolfine hydrochloride, ethanol, propylene glycol, polyethylene glycol, acrylic resin RL100, glyceryl triacetate, ethyl acetate and butyl acetate. The preparation method comprises the following steps: 1, selecting a solvent material; step 2, generation of an amorolfine raw material; step 3, synthesizing amorolfine hydrochloride; step 4, preparation of the liniment; step 5, quality control; and step 6, packaging and storing. The amorolfine hydrochloride liniment based on the acrylic resin RL100 as the coating and framework material is designed, the specific release requirement of the medicine can be effectively met, ultraviolet rays can be absorbed, erosion of the ultraviolet rays can be effectively resisted, and the service life of the medicine is prolonged; meanwhile, the propylene glycol component is added, so that the stability and solubility of the medicine and the permeability of the medicine are improved; the polyethylene glycol component is also added, so that the smearing property and the use experience of the medicine can be improved.

The invention discloses a salt-tolerant denitrifying bacterium and application of the salt-tolerant denitrifying bacterium, the salt-tolerant denitrifying bacterium is specifically Stutzerimonas degrandans and is named as Stutzerimonas degrandans BP, the preservation number of the salt-tolerant denitrifying bacterium is GDMCC No.64297, and the salt-tolerant denitrifying bacterium is preserved in the Guangdong Microbial Culture Collection Center on January 19, 2024. When the Stutzerimonas degrandans BP provided by the invention is used for biological nitrogen removal of high-salinity wastewater, the Stutzerimonas degrandans BP has relatively strong salt-tolerant denitrification capability, NO3 <->-N in a high-salinity water body can be effectively removed, no by-products such as NO2 <->-N and NH4 < + >-N are accumulated, and secondary pollution cannot be caused. Experimental results show that the Stutzerimonas degrandans BP provided by the invention is a facultative anaerobic bacterium, and is suitable for biological nitrogen removal in an anaerobic or anoxic environment. Under an anaerobic condition, high-efficiency salt-tolerant denitrification can be realized by virtue of relatively small biomass (OD600 = 0.15-0.25), so that the yield of sludge can be reduced while the operation cost of the process is reduced.

The invention provides an oral cavity soluble film solution based on a nano-carrier and a preparation method of an oral cavity soluble film. According to the method, a nano-carrier technology, microcapsule multilayer coating, a low-temperature electrochemical polymerization method and an ultrasonic dispersion technology are utilized, and uniform distribution and multi-stage slow release of a medicine in an oral instant film are achieved. According to the invention, active pharmaceutical ingredients are firstly wrapped by a nano-carrier, and then a multi-layer composite coating structure is formed by a microcapsule technology, so that drug release effects at different stages are realized. And then, uniformly mixing the microcapsule nano-drug particles with a film-forming substrate, depositing layer by layer to form a film through a low-temperature electrochemical polymerization method, and carrying out low-temperature drying treatment. The soluble film disclosed by the invention has good biocompatibility and mechanical strength, and can be gradually dissolved in an oral cavity, and the medicine is released according to a set stage, so that a long-acting oral care or treatment effect is realized. The method avoids the use of high temperature and organic solvents, is environment-friendly and safe, and is suitable for delivery systems of various oral drugs.

The invention discloses a lactam ring compound and application thereof, and belongs to the technical field of chemical medicines. The lactam ring compound as shown in the formula I provided by the invention can be used as a PARP1 inhibitor, has the advantages of high activity and high selectivity, and also has excellent pharmacokinetic properties and safety. # imgabs0 #

The invention provides a propolis soft capsule which comprises a soft capsule shell and a content wrapped in the soft capsule shell, and the content comprises 400-750 g of propolis extract, 2000-2400 g of vegetable oil, 1000-1400 g of modified starch, 75-100 g of tea seed oil, 50-100 g of natural antioxidant and 75-125 g of cellulose on the basis of 10000 propolis soft capsules. One of the purposes of the invention is to provide the propolis soft capsule and the production process thereof, and by optimizing the formula and the production process of the propolis soft capsule, the purposes of improving the bioavailability, enhancing the stability of the product, improving the mouth feel, improving the safety of the product and improving the environmental friendliness of the product can be achieved on the premise of not influencing the active ingredients of the propolis.

The invention belongs to the technical field of biological agriculture, and particularly relates to a method for promoting growth of natural calculus bovis by using a novel small molecule peptide combination, which comprises the following steps: selecting a plurality of small molecule peptides with specific functions, and mixing the small molecule peptides according to a specific proportion to form a small molecule peptide combination with a synergistic effect. The growth of the natural calculus bovis can be effectively promoted, and the yield and the quality of the natural calculus bovis are improved. Meanwhile, the method disclosed by the invention has relatively high safety and has a wide prospect in practical application. Animal experiment data further verifies the effectiveness and safety of the method.

The invention provides a lactobacillus rhamnosus Lr-Ca011 capable of promoting calcium absorption, a metagen, a calcium product and a nano emulsification and homogenization preparation method of the lactobacillus rhamnosus Lr-Ca011, and belongs to the technical field of probiotics. The lactobacillus rhamnosus Lr-Ca011 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32037, and the lactobacillus rhamnosus Lr-Ca011 can promote the absorption of calcium. According to the invention, the lactobacillus rhamnosus Lr-Ca011 is used for fermentation to prepare the metagen, and the metagen also has the effect of promoting calcium absorption. In addition, a water phase and an oil phase containing the metabiotics are mixed and dispersed to obtain a crude emulsion, and then a calcium product is obtained by adopting a nano-emulsification homogenization method. According to the nano emulsifying and homogenizing method, the crude emulsion forms more stable nano particles, release of functional components can be effectively controlled, a calcium product has the characteristic of high absorptivity, and the bioavailability of calcium is improved.

The invention discloses arthrobacter gandavensis N-15 with high selenium resistance and application of the arthrobacter gandavensis N-15, the arthrobacter gandavensis N-15 with high selenium resistance is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M20242146, and the preservation date is October 9, 2024. The arthrobacter gandavensis N-15 has the advantages that the arthrobacter gandavensis N-15 can be used for preparing the selenium-resistant arthrobacter gandavensis N-15; the selenium resistance of the arthrobacter dabarangensis N-15 reaches 128 mmol / L, and the arthrobacter dabarangensis N-15 has stable adaptability to high selenium concentration and is convenient for biological preparation of nano-selenium. The arthrobacter dawlini N-15 can be used for reducing sodium selenite to generate nano-selenium, and the generated nano-selenium has certain ABTS free radical scavenging capacity and DPPH free radical scavenging capacity, that is, the nano-selenium has relatively good antioxidant capacity. The arthrobacter dawlini N-15 and the nano-selenium produced by the arthrobacter dawlini N-15 can be widely applied to the fields of medicine, food and agriculture.

The invention relates to the technical field of food processing and functional drinks, and discloses a peptide-component-rich health-preserving liqueur which comprises the following components in percentage by weight: 50-65% of Maotai-flavor liquor, 10-20% of yellow wine, 3-7% of water, 10-20% of peptide components, 1-5% of plant extract and 5-10% of other components, the invention also discloses a preparation method of the health-preserving liqueur rich in peptide components, which comprises the following steps: S1, peptide treatment: carrying out directional enzymolysis on the peptide components, controlling the enzymolysis temperature at 40-50 DEG C and the enzymolysis time at 2-4 hours; and S2, microcapsule coating: coating the treated peptide components in cyclodextrin, gelatin or Arabic gum. By adopting a compound formula of multiple peptide components and combining technologies such as microcapsule coating, directional enzymolysis, low-temperature co-fermentation and nano-emulsification, the stability and bioavailability of the peptide components are remarkably improved, meanwhile, the flavor and taste of a wine body are optimized through a two-stage fermentation process, the wine body is more mellow and smoother, and the taste of the wine body is improved. The requirements of the market on the high-quality health-preserving liqueur are met.