40 results about "Injection site" patented technology

The invention discloses an administration agent in-vivo release and absorption visualization method based on a CFD-PBM coupling model. The method comprises the following steps: constructing a CFD model of a physiological environment of an injection site; establishing a population balance model (PBM) of the drug particles; the PBM is embedded into a CFD model solver, multi-scale coupling simulation is carried out, and a CFD-PBM coupling model is obtained; the three-dimensional visualization engine dynamically displays drug concentration distribution and particle behaviors; reversely adjusting preparation prescription parameters by using a multi-parameter optimization algorithm; and calibrating model parameters, and generating a key data report. According to the method, the prediction precision and the research and development efficiency can be remarkably improved, and the method is suitable for development of long-acting preparations such as microspheres and implants.

A method comprising validating a carbon dioxide injection operation plan at a carbon dioxide injection site, which comprises creating a first simulation model to simulate flow from the wellhead to a downhole environment and creating a second simulation model to simulate flow dynamics in a reservoir. The method further comprises conducting a carbon dioxide injection test operation based on the carbon dioxide injection plan at the carbon dioxide injection site and monitoring the carbon dioxide injection operation, which comprises measuring real-time data from the wellhead and the downhole, comparing the real-time data with the first simulation model, identifying risks from the comparison between the collected data in the first simulation model, and adjusting the carbon dioxide injection operation and based on the identified risks.

A method comprising validating a carbon dioxide injection operation plan at a carbon dioxide injection site, which comprises creating a first simulation model to simulate flow from the wellhead to a downhole environment and creating a second simulation model to simulate flow dynamics in a reservoir. The method further comprises conducting a carbon dioxide injection test operation based on the carbon dioxide injection plan at the carbon dioxide injection site and monitoring the carbon dioxide injection operation, which comprises measuring real-time data from the wellhead and the downhole, comparing the real-time data with the first simulation model, identifying risks from the comparison between the collected data in the first simulation model, and adjusting the carbon dioxide injection operation and based on the identified risks.

The invention relates to injectable cross-linked collagen gel and a preparation method thereof. Two crosslinking strategies of self-crosslinking and crosslinking agent crosslinking are fused together for the first time, and two types of amido bonds, namely amido bonds of a collagen-collagen structure (A) and amido bonds of a collagen-fatty amine-collagen structure (B), are respectively constructed through two crosslinking paths, namely catalysis of collagen polypeptide self-crosslinking and catalysis of fatty amine crosslinking, so that a hard / soft dual crosslinking network is obtained. The relative proportion of the structure A and the structure B in the final product is adjusted through a proper cross-linking process, so that the strength and the stability of the final product are adjusted and controlled, and the use requirements of different injection parts can be met.

1. The name of the design product: insulin injection simulation artificial skin. 2. The use of the design product: the product is mainly used to demonstrate injection site selection and injection process in subcutaneous injection education process. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: perspective view. 5. The design for which protection is sought contains color. 6. The back of the design product is a part that is not easy to see or cannot be seen during use, and the rear view is omitted.

The forming apparatus comprises a feed path for continuously feeding a continuous tow material along a transport direction, a forming device connected to a downstream end of the feed path and adapted to form the continuous tow material into a continuous tubular rod. The forming device comprises a tubular element adapted to allow the continuous tow material to pass through the tubular element to form the continuous tubular rod and a steam generator adapted to generate overheated steam. The steam generator is in fluid connection with the tubular element to provide overheated steam to the continuous tow material. The forming device further comprises several fluid conduits to provide overheated steam from the steam generator to several injection sites arranged along a length of the tubular element, wherein at least one fluid conduit of the several fluid conduits comprises a temperature control unit including a temperature sensor and a temperature influencer.

The utility model relates to the technical field of zipper production and processing, in particular to a zipper production and processing combination machine. The combined machine comprises a combined machine body, an injection molding opening is formed in the surface of the combined machine body, a protection device is arranged on the surface of the injection molding opening, the protection device comprises two square rods, the two square rods are fixedly connected with the surface of the injection molding opening, and the sides, close to each other, of the two square rods are rotationally connected with rotating rods; the arc surface of the rotating rod is fixedly connected with a protection plate, the surface of the protection plate is fixedly connected with a handle, and the surface of the square rod is fixedly connected with a square block. The problems that when the injection molding opening is not used for a long time, impurities such as dust in air are attached to the surface of the injection molding opening, the dust enters the injection molding portion of the zipper teeth, the shapes of the zipper teeth are possibly irregular, the zipper teeth are not tightly meshed, and therefore the zipper teeth are prone to being disengaged and the zipper is not smoothly zipped when the zipper is used are solved.

This invention relates to an artificial intelligence-based method and system for segmenting ultrasound-guided injection sites, belonging to the field of image processing technology. It includes the following steps: acquiring an image of the ultrasound-guided injection site and annotating the image with a segmentation mask; preprocessing the annotated image; constructing an ultrasound-guided injection site segmentation model, the model including a coarse segmentation module and a fine segmentation module; the coarse segmentation module adopts a U-Net network architecture, and the fine segmentation module includes an edge refinement unit and a second feature fusion unit; inputting the preprocessed image into the ultrasound-guided injection site segmentation model for training; optimizing the model using a loss function during training to obtain a trained model; inputting the image of the ultrasound-guided injection site to be detected into the trained model to obtain the ultrasound-guided injection site segmentation result. This invention can enhance the robustness of the ultrasound-guided injection site segmentation model and improve the accuracy of ultrasound-guided injection site segmentation.

The present invention relates to GIP / GLP1 agonist compositions. The present invention is a GIP / GLP1 co-agonist peptide pharmaceutical composition for subcutaneous injection. The composition comprises tirzepatide, NaCl, and disodium hydrogen phosphate. The composition provides commercially acceptable shelf-life stability, use-life stability, and an acceptable patient injection site experience. An alternative composition comprises tirzepatide, propylene glycol, and disodium hydrogen phosphate, which also provides acceptable shelf-life stability.

The present disclosure relates to an automatic injection device for automatically injecting a fluid in an injector to a target injection site. The syringe includes a barrel, a needle disposed at a first end of the barrel, and a movable element movable within the barrel, the movable element being drivable toward the first end of the barrel to inject fluid within the barrel into an injection site. The automatic injection device comprises an injector loading mechanism used for loading and fixing an injector; the injector driving mechanism comprises a first motor and a first actuating assembly, and the first actuating assembly can be driven by the first motor to enable the injector loading mechanism to move in the first translation direction towards the injection part so as to insert a needle of an injector fixed to the injector loading mechanism into the injection part; and a dose control mechanism comprising a second motor and a second actuation assembly capable of moving the movable element of the syringe towards the first end of the barrel under the drive of the second motor to expel a predetermined dose of fluid from the barrel of the syringe and inject it into the injection site.

The present invention discloses an injection molding machine for plastic processing, which relates to the technical field of injection molding machines and includes a frame, an injection component for extruding raw materials, the frame being sequentially provided with a driving component, an injection component, a hopper, and a molding component, and a control mechanism for removing bubbles present in the injection component, the driving component including a driving motor and a transmission gear set, the transmission gear set being connected to the driving motor. By improving the injection component in an existing injection molding machine, the injection molding machine does not need to be vented during use, so that the injection site is maintained in a relatively vacuum state, and bubbles generated during the subsequent addition of raw materials to melt, mix, stir, and promote the raw materials can be effectively removed, ensuring that the raw materials injected into the mold are bubble-free, effectively avoiding defects in the injection molded product caused by bubbles in the liquid.

The present invention relates to a combination of a first vaccine comprising a non-replicating immunogen of porcine erysipelothrix sp. And a non-replicating immunogen of porcine parvovirus and a second vaccine comprising a non-replicating immunogen of leptospira sp. And the first vaccine and the second vaccine are jointly injected into corium layers of a first injection part and a second injection part of the pig at different points to prophylactically treat the pig so as to resist swine erysipelothrix erysipelas infection, porcine parvovirus infection and leptospirosis infection.

A fluid handling system, method, and computer-readable storage medium are presented for controlling the flow and injection pressure of fluid injected into a subterranean void at an offshore injection site for long term storage. A subsea template receives fluid from a fluid storage is arranged on a seabed in connection with at least two well heads for at least two drill holes to the void. For each drill hole, a first pressure gauge at the bottom opening of the drill hole measures a bottom pressure, PB. The template comprises a utility system causing received fluid to be injected into the void and includes a valve system with a choke valve for each drill hole to control the injection of fluid into the void in response to control commands (Ccmd) based on a pre-set desired flow rate for each drill hole and a pre-set lowest allowable flow rate from the fluid storage.

An embodiment of a resettable injection training device is provided including a housing defining a receptacle having an opening, including a top side and a bottom side, a resettable, removable container receivable within the receptacle including a stopper that is movable within the container. The device also includes an actuation member configured to simulate actuation of an injection device, one or more sensors comprising a container sensor for detecting receipt of the container within the receptacle, a safety latch extending from the bottom side of the device, said safety latch for contacting an injection site, and a processor for detecting a condition of the one or more sensors, and optionally, providing feedback based on the condition detected. In a further embodiment, the device includes an adhesive associated with the housing for affixing the housing onto the injection site during use of the device.

The forming apparatus comprises a feed path for continuously feeding a continuous tow material along a transport direction, a forming device connected to a downstream end of the feed path and adapted to form the continuous tow material into a continuous tubular rod. The forming device comprises a tubular element adapted to allow the continuous tow material to pass through the tubular element to form the continuous tubular rod and a steam generator adapted to generate overheated steam. The steam generator is in fluid connection with the tubular element to provide overheated steam to the continuous tow material. The forming device further comprises several fluid conduits to provide overheated steam from the steam generator to several injection sites arranged along a length of the tubular element, wherein at least one fluid conduit of the several fluid conduits comprises a temperature control unit including a temperature sensor and a temperature influencer.

In accordance with an embodiment, a handheld intraoral scanner system is disclosed. A handheld intraoral scanner system includes a handheld intraoral scanner and a removable sleeve configured to be removably attached to a scanning tip of the handheld intraoral scanner. The removable sleeve includes a cover member and a window member. The window member includes a tapered portion. The window component may be injection molded. The removable sleeve may be formed by injection molding a dual assembly of a cover member and a window member. The window member includes an optical region having a lower birefringence than an unloading region located at the tapered portion, and includes an injection site at which a first molten polymer material is injected into the first core to form the window member. In accordance with an embodiment, there is provided a method for injection molding a window component for a removable sleeve, the removable sleeve further comprising a cover component and configured to be removably attached to a handheld intraoral scanner. The method may further include injection molding the lid member and the window member bi-assembly together to form a removable sleeve.

The application provides a fast-acting flunixin meglumine injection and a preparation method thereof, and belongs to the technical field of veterinary medicine, and contains the following components: flunixin meglumine 5-10 (w / v) %, alpha-pyrrolidone 10-30 (w / v) %, hydrophilic solvent 0.5-1 (w / v) %, antioxidant 0.1-0.3 (w / v) % and the balance of water for injection. The application takes flunixin meglumine as the main drug, matches alpha-pyrrolidone as a solvent and a targeting guide distribution component, uses a hydrophilic solvent to assist dissolution and promote absorption, and uses an antioxidant to inhibit the oxidative degradation of the main drug, so that the dissolution and absorption rate of the main drug and the target tissue distribution efficiency can be effectively improved, the storage stability can be ensured, the bacterial endotoxin and the injection site redness rate meet the requirements, the acute inflammation and pain of livestock and poultry can be quickly and efficiently relieved, and the demand for instant intervention in large-scale breeding can be met.

An apparatus for targeting an injection site using anatomical landmarks includes a first landmark identifier, a second landmark identifier, and a targeting band. The targeting band is connected with the first landmark identifier at a first end and a second landmark identifier at a second end. At least a portion of the targeting band is linearly deformable. In another embodiment, an apparatus for targeting an injection site using anatomical landmarks on a patient includes a targeting band having a first end and a second end, at least a portion of the targeting being linearly deformable, a first landmark identifier pivotably connected to the targeting band at the first end, a second landmark identifier configured to be connected with the second end of the targeting band; and a fastener configured to secure the first and second landmark identifiers to the patient.

The invention relates to an ultrasonic guided injection site segmentation method and system based on artificial intelligence, and belongs to the technical field of image processing. The method comprises the following steps: acquiring an ultrasonic guided injection site image, and marking a segmentation mask in the image; the annotated image is preprocessed; constructing an ultrasonic guided injection site segmentation model, wherein the model comprises a coarse segmentation module and a fine segmentation module; the coarse segmentation module adopts a U-Net network architecture, and the fine segmentation module comprises an edge refining unit and a second feature fusion unit; inputting the preprocessed image into an ultrasonic guided injection site segmentation model for training; optimizing the model by using the loss function in the training process to obtain a trained model; and inputting a to-be-detected ultrasound-guided injection site image into the trained model to obtain an ultrasound-guided injection site segmentation result. According to the invention, the robustness of the ultrasound-guided injection site segmentation model can be enhanced, and the accuracy of ultrasound-guided injection site segmentation is improved.

Disclosed herein are system and method embodiments for fluoroscopic image based analysis of in-vivo fluid injections. For example, the method includes: obtaining a fluoroscopic image of an injection site, the fluoroscopic image including a matrix including a plurality of elements, and each element of the matrix including an intensity value; processing the fluoroscopic image to generate a prediction score for each element including a prediction of whether that element includes a fluid delivery depot location; providing a total area of the fluid delivery depot location, the total area of the fluid delivery depot location being determined based on the prediction score for each element of the plurality of elements; generating, based on the total area, at least one predicted parameter associated with the injection; and providing the at least one predicted parameter associated with the injection as a delivery characteristic.

A device for drug delivery includes a casing for housing a drug storage container including a dose delivery member. At least a portion of the dose delivery member extends through an opening in the casing. A guard is movable relative to the casing between an extended position and a retracted position. An interference arrangement provides a selected threshold of resistance to movement of the guard from the extended position to the retracted position during insertion of the dose delivery member into body tissue at an injection site. The interference arrangement has a first member and a second member engaging one another to retain the guard in the extended position. One of the first member and the second member moving if the selected threshold of resistance is exceeded to allow the first member and second member to slide past one another to allow the guard to move into the retracted position.

An automatic injection device is disclosed. The syringe includes a barrel for containing the fluid, a needle arranged at a proximal end of the barrel, and a movable plunger rod movable within the barrel. The automatic injection device includes a syringe retaining assembly for retaining the syringe; and a syringe driving assembly including a housing and a driving mechanism releasably arranged in the housing. The driving mechanism includes a movable body moveable after the driving mechanism is released, a first driving spring and a second driving spring, wherein the second driving spring is configured to drive the barrel of the syringe to move proximally to insert the needle of the syringe into an injection site of a target, and the first driving spring is configured to drive the movable plunger rod to move proximally to carry out injection; and the first and second driving springs have different spring stiffnesses.

The invention provides an automatic needle inserting injection pen, and belongs to the technical field of automatic injectors. The automatic needle inserting injection pen comprises a front shell assembly and a rear shell assembly. The cap cover is installed at the front end of the front shell, the brake sleeve is inserted into the front shell, and a slope elastic step is arranged in the cap cover; the inner driving sleeve is sleeved with the outer driving sleeve, an elastic arm at the front end of the inner driving sleeve is sleeved with a chute of the fixing sleeve, injection is started as active needle insertion, liquid medicine injection is started after a needle head reaches a preset depth, the brake sleeve can automatically pop up to an initial position and is locked to carry out needle hiding action, and the needle is not synchronously and automatically withdrawn after injection is finished. And the sufficiency of injection dosage is effectively ensured. The active needle inserting and triggering protection functions are adopted, when a user starts triggering of the injector, the needle head can actively enter an injection part, manual insertion injection is not needed, the injection fear is eliminated, the needle hiding protection function is achieved when the injector is loosened after injection is completed, and the needle head does not need to be additionally covered or self-destroyed.

The utility model belongs to the technical field of flue gas purification, and relates to a device for improving calcium-based dry desulfurization efficiency by dynamically jetting nanofluid, which comprises a nanofluid supply facility, a nanofluid ejector and a control system, the nanofluid supply facility comprises a nanofluid generator, a nanofluid conveying switch valve, a fluid pump, a nanofluid spraying time control electromagnetic valve, a nanofluid spraying flow control regulating valve and a nanofluid spraying site switch valve which are sequentially connected in the flowing direction of nanofluid. An outlet of the nanofluid injection site switch valve is connected with the nanofluid injector; the nano-fluid generator, the nano-fluid conveying switch valve, the nano-fluid spraying time control electromagnetic valve, the nano-fluid spraying flow control regulating valve and the nano-fluid spraying site switch valve are all connected with a control system; the nano-fluid ejector is arranged in a flue gas pipeline, is a multi-fluid ejector and is at least provided with more than two groups of forward-spraying / reverse-spraying injection heads.

The invention discloses a treatment method for air leakage at the joint of a furnace bottom and a furnace wall of a roasting furnace, and belongs to the technical field of wet smelting. Comprising the following steps of air leakage judgment; and air leakage treatment is conducted, specifically, a repairing and plugging agent is selected, holes are drilled in a furnace body shell in a staggered mode, the hole diameter of the drilled holes is 10 mm, the distance between the drilled holes is 300-600 mm, the repairing and plugging agent is injected at the high pressure not higher than 0.1 MPa, it is guaranteed that each glue injection part is fully filled, after the glue solution reaches a certain pressure, air channeling gaps among a steel plate, heat preservation bricks and refractory bricks are fully filled, and an overall sealing layer is formed after the glue solution is solidified; repairing a leakage part; and repairing the internal annular groove. Through combination of roasting furnace parameter abnormal fluctuation and physical furnace detection, the air leakage point positioning problem at the joint of the hearth and the boiling layer furnace wall is solved, and the positioning accuracy is improved to 90% or above. The long-acting repairing effect can be achieved. The method is remarkable in economic benefit.

The invention relates to a control device (10) for open-loop and / or closed-loop control of an injection pressure of a fluid and of an intraocular pressure when injecting the fluid at an injection site between two tissue layers of the human eye (1). The control device (10) contains an open-loop or closed-loop control unit which is designed for open-loop or closed-loop control of the injection pressure and the intraocular pressure in such a way that the gradient between the injection pressure and the intraocular pressure assumes a predetermined value.

The invention discloses an egg cytoplasm single sperm injection method based on image recognition, and belongs to the technical field of assisted reproduction, the method comprises the following steps: constructing a high-quality sperm evaluation feature tag, screening high-quality sperms by using a convolutional neural network model, and meanwhile, carrying out image acquisition and processing on ovum cells; obtaining an ovum edge image and an internal organelle segmentation image; in the aspect of injection point selection, through image fusion and analysis, multiple parameters such as cytoplasm gray scale, mitochondrial quantity and distance from cell nucleus are comprehensively considered, potential injection points are evaluated, evaluation values are calculated, and finally the optimal injection point is determined; according to the invention, the precision of sperm screening and ovum injection site selection is realized, the success rate of ovum cytoplasm single sperm injection is obviously improved, the problem of fertilization failure caused by poor sperm quality or inaccurate injection site is reduced, and a powerful technical support is provided for the development of an assisted reproduction technology.

A refrigerator appliance includes a cabinet defining an insulation receiving space between an outer casing and an inner liner, a dividing wall positioned within the insulation receiving space to divide the insulation receiving space into a first portion and a second portion, a first injection site for a first foam, and a second injection site for a second foam. The dividing wall includes one or more apertures therethrough.

The invention belongs to the technical field of oil reservoir development, and discloses a gas injection well anti-explosion system and a using method thereof.The gas injection well anti-explosion system comprises a gas seal, a gas injection pipe, an anti-corrosion oil pipe, a safety valve and a temperature and voltage measuring galvane.The gas seal is used for sealing a wellhead, the wellhead is located on the ground, and the gas seal and the wellhead are both arranged in a well pipe; the anti-corrosion oil pipe is communicated with a well mouth and the gas injection pipe, the gas injection pipe is located at a gas injection layer at the well bottom and used for gas injection perforation, the safety valve is arranged in the anti-corrosion oil pipe to control on-off of the interior of the anti-corrosion oil pipe, the safety valve is located underground and can be remotely controlled to be opened and closed, and the temperature and voltage measuring thermocouple penetrates through the well mouth and is located in the anti-corrosion oil pipe. The output end of the temperature and pressure measuring couple is located in the gas injection pipe and used for monitoring the bottom hole temperature and pressure. According to the gas injection well explosion-proof system and the using method thereof, risk monitoring, identification and handling are conducted on an air injection well in time on a gas injection site.

The invention provides a method for rat or mouse intraperitoneal injection and determining that an injection needle enters the rat or mouse intraperitoneal state. The rat intraperitoneal injection method comprises the steps that a rat is fixed; at the injection position, the injection needle penetrates subcutaneously and penetrates through the abdominal muscle of the mouse to pierce into the abdominal cavity; determining that the injection needle enters an abdominal cavity state. Standardized operation procedures are carried out on a rat or mouse fixing method, injection position determination and judgment on whether an injection needle enters the abdominal cavity state, the success rate of intraperitoneal injection is effectively increased, the mechanical stimulation and bleeding risk of abdominal tissue are reduced, the cecum and small intestine puncture risk is reduced, stress response is reduced, and the safety of intraperitoneal injection is improved. And technical support is provided for drug research and development and disease model construction.