317 results about "Prefilled Syringe" patented technology

There can be provided a sealing stopper for a syringe, having very high sealing property and sliding property, and a prefilled syringe using this sealing stopper and capable of preserving a medicament for a long time and operating in easy and precise manner during injecting. This syringe is also excellent in sanitary and operating property during a step of formulation or preservation of a medicament. In this sealing stopper for a syringe, a surface of the rubber body is laminated with a tetrafluoroethylene resin film or ultra-high molecular weight polyethylene film having an average roughness Ra on the central line of the surface in a range of at most 0.05 mu m and a kinematic friction coefficient of at most 0.2.

A contrast media injection system includes detects the absolute position of the syringe ram using a non-contact sensor. A series of magnets and Hall-Effect sensors may be used or an opto-reflective system. Illuminated knobs that are connected to the drive mechanism for the syringe ram rotate with the drive and provide visual feedback on operation through the illumination. Analog Hall-Effect sensors are used to determine the presence or absence of magnets that identify the type of faceplate being used. The faceplates include control electronics, connected to the powerhead through connectors, which may be interchangeably used by the two faceplates. The faceplate electronics include detectors for automatically detecting the capacity of pre-filled syringes. Additional features include using historical data to provide optimum pressure limit values during an injection protocol, a removable memory device for storing and transferring information such as injection protocols and injector statistics, and password protection of such protocols.

An automatic injection and retraction device having a longitudinal axis is provided that includes an injection assembly, a retraction assembly, and a pre-filled syringe cartridge. The injection assembly has an activation-prevention feature moveable between an on position and an off position. The retraction assembly has a needle guard that is removable in a direction along the longitudinal axis upon application of a removal force. The pre-filled syringe cartridge has a hypodermic needle with a needle sheath thereon. The retraction and injection assemblies are secured to one another so that the pre-filled syringe cartridge is in the retraction assembly with the needle sheath secured to the needle guard. The retraction and injection assemblies are configured so that, upon application of a twisting torque to the injection and retraction assemblies, the activation-prevention feature moves from the on position to the off position simultaneous with applying the removal force to the needle guard.

A prefilled syringe and syringe assembly having a syringe and a tip cap are produced from materials that do not interfere with the substance contained in the syringe and enable long term storage. The tip cap is made from a blend of a cyclic olefin polymer or copolymer and a thermoplastic elastomer. The thermoplastic elastomer is blended with the cyclic olefin copolymer in an amount so that the normally stiff and hard cyclic olefin copolymer is flexible and resilient to effectively seal and couple to the tip of a prefilled syringe.

The present invention is directed to improved formulations for dihydroergotamine in which the drug is present at a concentration of at least 2.9 mM. The invention encompasses methods for using these formulations in treating patients for migraine headaches and the packaging of formulation into prefilled syringes for self-administration by patients.

To provide a drug solution preparing kit which can be handled with ease in a substantially aseptic manner, and has no risk that a leakage of a drug solution such as a splash and a dispersion of an aerosol to an ambient environment occurs upon preparation of the drug solution There is provided a drug solution preparing kit including a pre-filled syringe and a transfusing tool, wherein the pre-filled syringe includes a sealing member which seals the tip end and can not be removed from the tip end, and that the transfusing tool includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to the second communication channel with respect to the one-way valve.

A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with said main body adjacent the closed front end. The core member includes a nose portion having a profile adapted to create a positive seal with an outlet opening of such syringe barrel.

The invention provides a syringe or autoinjector for dispensing a drug comprising a rigid syringe body containing the drug, an oxygen absorbing material, a separating element between the drug and oxygen absorbing material to prevent the drug from contacting the oxygen absorbing material but which allows oxygen to pass from the drug to the oxygen absorbing material, and an oxygen impermeable container enclosing both the drug and the oxygen absorbing material, wherein the oxygen impermeable container partially or fully forms the rigid syringe body or is held within the rigid syringe body.

A lockable safety shield assembly for a prefillable syringe is provided. The design of the lockable safety shield assembly enhances pharmaceutical manufacturers' ease of assembling the various components as part of its filling or processing of the prefillable syringes in normal practice, while at the same time minimizes difficulties in mating parts made from different materials. A tube is placed around the outside surface of the syringe barrel and affixed thereto. A collar is provided on the tube adjacent the distal end of the syringe barrel. A safety shield is axially slidable over the tube between a retracted position, wherein the distal end of the piercing element associated with the prefillable syringe is exposed, and an extended position, wherein the safety shield is locked to the collar to protectively cover the distal end of the piercing element. The safety shield includes locking structure configured so that the shield can be easily fitted over the tube. The locking structure includes at least one deflectable arm provided on the body of the shield. The deflectable arm includes a proximal end deflectable towards the interior of the shield. A stop member is provided on the interior of a shield in spaced relation to the proximal end of the deflectable arm. A ring is axially slidable over the shield to deflect the arm towards the interior of the shield to activate the locking structure. The safety shield is slid distally by an end user such that the collar is lockingly retained between the stop member and the proximal end of the deflectable arm. The collar, the stop member, and the deflectable arm may be configured to provide tactile as well as audible indication of locking to the end user.

A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.

A two-chamber type pre-filled syringe (1) includes an outer cylinder (2) having a projected portion (14b) for breaking use provided inside the outer cylinder (2); an inner cylinder assemblage (20) having an inner cylinder (5), an annular first gasket (6) provided in the vicinity of a front-end portion of the inner cylinder (5), and a sealing member (13) which airtightly seals a front-end portion of the inner cylinder (5) and can be broken by the projected portion (14b) for breaking use; a second gasket (7) accommodated inside the inner cylinder (5); a plunger (8) mounted at a rear-end portion of the second gasket (7); a first accommodation portion (9); a second accommodation portion (11); a medicine-dissolving liquid (10) accommodated in the first accommodation portion (9); and a powdery or frozen dry medicine (12) accommodated inside the second accommodation portion (11).

A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.

A single-use injection device, includes a pre-filled syringe (1), a syringe body (5) which is integral with the said syringe, and a protective case (10), the syringe body and protective case being provided with elements (9, 14, 15, 21) for relative locking in translation, which permit their relative displacement between a position of injection and a position of protection after use. The injection device includes a locking ring (23), which is provided with digital support elements (24), and locking units (25), which can lock the syringe body (5) and the protective case (10), in their position of injection, during injection, and can be displaced axially, such as to permit relative displacement of the syringe body and protective case, towards their position of protection after use, under the effect of the action of resilient member (27), only when the plunger (4) has reached its end of travel.

A plastic prefilled syringe (10) including a syringe body (11) and a plunger assembly (12), the syringe body (11) having opposed first (13) and second (14) ends and an inner wall (16) defining a cylindrical chamber (15) which contains an injectable solution (100), the first end (13) of the syringe body (11) being sealed by a closure and the second end (14) incorporating an opening (18), the plunger assembly (12) including a plunger shaft (22) extending through said opening (18) and a stopper (24) secured at an end of said shaft (22) within said chamber, the plunger assembly (12) being movable within the chamber with the stopper (24) being operable to seal the opening (18) wherein the plunger assembly (12) includes barrier means (26 and 29) on said shaft (22) the barrier means (26 and 29) being adapted, in conjunction with a part of the syringe body (16 and 19), to inhibit access to the injectable solution (100) through the opening (18).

A retractable syringe (11) and plunger (20) therefore are provided, whereby the plunger comprises a controlling means (62) which facilitates control of the rate of retraction of the retractable needle. By controlling the rate of needle retraction, the likelihood of blood spattering is reduced, thereby improving the user-friendliness and appeal of the retractable syringe. Typically, the syringe is a prefilled syringe. Following plunger depression, a symmetrical ejector member (92) releases the retractable needle (40) from a retaining member (30) to thereby allow retraction of the retractable needle. Needle retraction is facilitated by a biasing means (70), such as a spring or other compressible and/or de-compressible device. The plunger comprises a plunger housing (21), in which is located the controlling means. The controlling means may be a pneumatic air space (324) inside the plunger housing which automatically acts against the retracting needle to thereby control or regulate the rate of retraction.

A high silica glass composition comprising about 82 to about 99.9999 wt. % SiO₂ and from about 0.0001 to about 18 wt. % of at least one dopant selected from Al₂O₃, CeO₂, TiO₂, La₂O₃, Y₂O₃, Nd₂O₃, other rare earth oxides, and mixtures of two or more thereof. The glass composition has a working point temperature ranging from 600 to 2,000° C. These compositions exhibit stability similar to pure fused quartz, but have a moderate working temperature to enable cost effective fabrication of pharmaceutical packages. The glass is particularly useful as a packaging material for pharmaceutical applications, such as, for example pre-filled syringes, ampoules and vials.

The present invention provides apparatus and systems for enabling and monitoring injection of medicinal fluids into a subject. The invention includes a housing for a prefilled syringe, the housing incorporating means for generating and sending signals as parts of the syringe cooperate to deliver the fluids. The signals may be transmitted from a transmitter on the housing as radiowaves to a receiver, which may be conveniently located on a spaced device, such as a mobile phone. The mobile phone or other receiving device incorporates computer software to receive, store the signals from the transmitter as a record of the injection process. The computer software may include information about the medicine, the injection process, and other information relevant to a treatment regime. In some cases, the receiving device may transmit information stored by the computer software for storage and analysis.