256 results about "Prefilled Syringe" patented technology

The utility model discloses a quantitative dosing prefilled syringe, which comprises a syringe filled with a preset amount of liquid medicine in advance, and further comprises an injection push rod capable of being inserted into the syringe in an axial moving manner, and a dosage adjusting mechanism capable of being arranged on the syringe in an axial moving manner, the injection push rod is used for pushing liquid medicine in the injection cylinder to flow out, and the dosage adjusting mechanism is used for abutting against the limiting piece so as to limit the pushing stroke of the injection push rod. Thus, when a medical worker needs to inject a small dose at a time, the medical worker only needs to adjust the axial position of the dose adjusting mechanism according to the target axial distance corresponding to the target injection dose, then the injection push rod is pressed to start injection till the limiting piece abuts against the dose adjusting mechanism, and the maximum pushing stroke is achieved; therefore, it can be ensured that the actual injection dosage is equal to the target injection dosage, accurate injection of any dosage can be achieved, the requirement for accurate injection of single-time tiny dosage is met, and the treatment effect of a multi-injection administration mode is ensured.

A spiral excitation assembly of a prefilled automatic injection pen and a prefilled automatic injection pen comprising the spiral excitation assembly. The spiral excitation assembly of the prefilled automatic injection pen comprises: a cavity (6) for changing a rotary motion of a threaded push rod (5) into an axial forward movement; a nut (9), which is capable of being rotatably mounted in the cavity (6) relative to the cavity (6), with a torsion spring (7) capable of driving the nut (9) to rotate being arranged between the nut (9) and the cavity (6); the threaded push rod (5), which is in threaded connection with the interior of the nut (9) and driven by the rotation of the nut (9) to move forward and then drive a prefilled syringe (4) to move to complete automatic needle insertion; a clutch member (10), which is sleeved outside the nut (9) and capable of being driven by an excitation sleeve (3) of the prefilled automatic injection pen to move from an engaged position to an excitation position, wherein the clutch member engages with the nut (9) to stop the nut (9) when in the engaged position, and the nut (9) can rotate when the clutch member is in the excitation position; and a clutch spring (8), which is mounted between the clutch member (10) and an end cover (11) and is used for driving the clutch member (10) from the excitation position into a limiting position to limit backward movement of the excitation sleeve (3) to achieve needle protection post-injection, and to cause the clutch member (10) to collide with the nut (9) to produce a sound.

Provided herein are pharmaceutical compositions and formulations of a conjugate comprising a first protein, such as an anti-VEGF antibody, conjugated to a phosphorylcholine-containing polymer, and a second protein that is not conjugated to a phosphorylcholine-containing polymer. The second protein can be the same as the first protein, or can be different. In some embodiments, the pH of the formulation is different from the isoelectric point (pI) of the second protein so as to prevent or reduce turbidity of the formulation. Also provided are methods of preparing the formulations, methods of use thereof, and kits with pre-filled syringes containing the formulations.

The invention discloses an auxiliary device for preventing an injector from needling. The auxiliary device aims to solve the problems that an existing passive protection device is prone to being started by mistake, a push rod is prone to inclining, protection is not achieved after injection, and adaptability is poor. The device comprises an outer shell, a compression spring, an inner shell, a disposable prefilled syringe and a push rod. The shell is an external support and is provided with a guide bone position, an elastic step, a guide channel, an elastic buckle and the like; the inner shell is assembled in the outer shell, bears the injector and is connected with the compression spring; the push rod is in threaded connection with the syringe piston, and the actuating rod is inserted into the shell guide channel. The device realizes single-hand operation and automatic protection, does not need an additional activation step, is adaptive to a medicine production process, effectively reduces the risk of pricking injury, and avoids waste of liquid medicine. And the clinical use safety and the operation convenience are improved.

The disposable injection pen comprises an upper pen shell assembly and a lower pen shell assembly which are assembled and matched, the lower pen shell assembly comprises a pen cap and a protective shell clamped in the pen cap, and a bracket for supporting a pre-filled syringe is arranged on the inner ring of the protective shell; a pen cap spring extending towards the bracket is arranged on the pen cap; and the pen cap spring is in pressing fit with the axial edge of the needle protecting cap. According to the lower pen shell assembly, a protective shell installed in a pen cap lifts and supports a bracket, a pre-filled syringe can be fixedly installed in the bracket, a pen cap spring is arranged in the pen cap, the axial edge of a needle protecting cap is pressed and matched through the pen cap spring, the pen cap of a spring structure is arranged, the spring is pressed on the circumferential edge of the needle protecting cap, and therefore the pre-filled syringe can be fixed to the bracket. Therefore, the needle protecting cap is subjected to axial pulling-out acting force, the clamping structure is stable, and smooth pulling out of the needle protecting cap is guaranteed.

According to the double-cavity prefilled syringe with the equal-diameter channels and the prefilling method, firstly, a middle piston is installed through mechanical plugging, then sterile powder in a first medicament cavity is filled, and after a rubber gasket, a Luer lock adapter and a protective cap assembly are assembled, sterile powder is filled in the first medicament cavity in a pressing mode; the Ruhr lock adapter annular buckle is guided by the auxiliary conical surface to be fixed to the limiting groove, at the moment, the rubber gasket is pressed by the mechanical sealing structure, meanwhile, the protective cap assembly seals the Ruhr lock medicine outlet, and a cavity close to the medicine outlet is well sealed. Then the double-cavity pre-filling syringe is turned over, the solvent is filled from a flange inlet, filling of the second medicament cavity is completed, a push rod piston is installed through mechanical plug adding, and a cavity far away from a medicament outlet is well sealed. According to the invention, the two ends of the needle cylinder are adopted to realize pre-encapsulation administration, so that the administration residue or pollution can be avoided, and the rubber gasket, the Luer lock adapter and the protective cap assembly are matched to realize high-precision sealing.

A disposable syringe unit for an injection device adapted for releasable attachment to a reusable drive unit of the injection device includes a prefilled syringe with a reservoir and an injection needle, a syringe holder for holding the prefilled syringe, a cover member guided by guiding means thereby movable along the longitudinal axis relative to the syringe holder between a covering position in which the injection needle is covered and a retracted position in which the injection needle protrudes from the cover member, and a cap releasably attached to a distal end of the cover member or the syringe holder. Apart from the prefilled syringe, the syringe unit includes in total not more than three separate parts.

The invention relates to a disposable syringe unit (2) for an injection device (1), which is adapted to be releasably attached to a reusable drive unit (3) of the injection device. The syringe unit (2) comprises: a pre-filled syringe comprising a reservoir and an injection needle (18); and a syringe holder (30) for holding the pre-filled syringe (15). The syringe unit further comprises: a cover member (20) guided by the guide means (31) thereby being movable along the longitudinal axis relative to the syringe holder (30) between a cover position in which the injection needle (18) is covered and a retracted position in which the injection needle (18) protrudes from the cover member (20); and a cap (10) releasably attached to the distal end of the cover member (20) or the syringe holder (30). In addition to the pre-filled syringe, the syringe unit (30) comprises no more than three separate components in total.

The invention relates to the technical field of pre-filled medicine bottles, in particular to a device for providing needle hiding and post-injection needle puncture-proof protection and a pre-filled syringe, the device comprises a needle hiding sleeve, a medicine bin shell, a locking sleeve, a medicine bottle support and a locking sleeve ejector rod, and the needle hiding sleeve is arranged in the medicine bin shell; a locking sleeve is arranged above the needle hiding sleeve, a medicine bottle support is arranged in the locking sleeve, and a pre-filled medicine bottle is arranged in the medicine bottle support; the bottom of the locking sleeve and the upper portion of the needle hiding sleeve are mutually embedded, and a locking sleeve ejector rod is arranged above the medicine bottle support. When injection is not carried out, the locking sleeve and the needle hiding sleeve can move freely; after injection is completed, the locking sleeve is locked by the locking sleeve ejector rod, so that the hidden needle in the pre-filled medicine bottle cannot be exposed. No matter whether the device is connected with a host or not, the needle head can be hidden when injection is not carried out, removal of the hidden needle protective cap is not affected, and friendly experience is provided for a user fear of needle fear; after injection, the hidden needle sleeve is locked, the hidden needle is prevented from being exposed, a needle head is prevented from stabbing related personnel, and the use safety is improved.

A polymer double-cavity prefilled syringe comprises a barrel with a bypass, the barrel is provided with a finger handle and an adapter, a needle seat is arranged on the adapter, a needle body is fixed on the needle seat, and a protective cap is arranged on the outer side of the needle body. A front plunger, a middle plunger and a rear plunger are arranged in the barrel, and the rear plunger abuts against a plunger rod. The cylinder is formed by integral injection molding of polymer, a group of ribs which are arranged side by side and protrude towards the interior of the cylinder are arranged on the inner wall of the cylinder, the axial length of each rib is larger than that of the middle plunger, the bypass is formed by a gap between every two adjacent ribs, and the outer diameter of the cylinder is larger than that of the adapter; the protective cap is tightly connected with the needle seat, a first anti-falling mechanism is arranged on the joint face of the protective cap and the needle seat, and an inner cavity of the protective cap is communicated with the outside through a bacteria-blocking, hydrophobic and breathable filter membrane. The bypass is formed in the mode that the protruding edges protrude inwards, demolding is convenient, integrated injection molding machining can be conducted through polymers, cost is low, damage is not prone to occurring, and the using effect is good. The outer surface of the cylinder is smooth, the heat conduction performance is good, and the vacuum freeze-drying efficiency is high.

The invention provides a disposable injection pen and an injection prompt structure thereof, the injection pen is characterized in that an upper pen shell assembly drives a pre-filled syringe in a lower pen shell assembly to realize an injection function, a rotary sleeve and a screw rod which are rotatably matched are arranged in the upper pen shell assembly, and the injection function of the syringe is completed by axially pushing the screw rod; according to the technical scheme, the sound part which synchronously rotates is arranged on the rotating sleeve, and at the tail end of injection work execution, the sound part axially slides relative to the rotating sleeve and collides with the rotating sleeve in the sliding process to make a prompt tone so as to prompt that injection is completed; the prompt tone of injection completion can be accurately prompted, and the user experience is improved.

An apparatus includes a housing, a medicament container and a movable member. The medicament container is movable within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member exerts the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member exerts a retraction force on the flange to move the medicament container from the second position towards the first position.

According to the high-molecular double-cavity pre-filled syringe, before injection is prepared, pushing force is applied to the push rod and transmitted to the liquid medicine sealing plug through the push rod, the push rod pushes liquid medicine and the middle sealing plug to move forwards together, and when the end face of the rear end of the middle sealing plug is separated from the plane where the rear end of the liquid medicine channel is located, the liquid medicine channel is closed. Liquid medicine flows into the medicine powder loading chamber from the liquid medicine loading chamber through the liquid medicine channel. After liquid medicine enters the medicine powder loading chamber from the liquid medicine loading chamber, the injector is slightly beaten and shaken left and right, so that the medicine powder and the liquid medicine are fully mixed. After blending is completed, the liquid medicine sealing plug continues to be pushed and injected, the space of the medicine powder loading chamber is compressed, the powder sealing plug is moved to the sealing lock cap, at the moment, the liquid medicine flows out of the liquid discharging groove to the injection needle, and the injection process is completed. Quick mixing of medicine powder and liquid medicine is achieved, and the powder and liquid medicine dispensing mode is more efficient and safer. The invention further provides a preparation method of the high-molecular double-cavity pre-filled syringe. The preparation method comprises the steps of burdening, injection molding, silicification of the blending tube and assembly of a finished product.

According to the disposable injection pen and the injection unlocking structure thereof, a pre-filled syringe is assembled in a lower pen shell assembly and is driven by a driving device in an upper pen shell assembly to conduct injection, in the injection process, the lower pen shell assembly drives a rotary sliding block in the upper pen shell assembly to move upwards so that an injection needle can be exposed, the rotary sliding block slides on a fixed sleeve, and therefore the injection needle can be unlocked. The driving device in the upper pen shell assembly is unlocked in the sliding process, the rotary sliding block which is rotatably arranged axially slides before reaching the unlocking position, and the rotary sliding block rotates after reaching the unlocking position and collides with the fixed sleeve to make an unlocking prompt tone, so that a user can accurately know the injection starting condition; and the subsequent injection action can be accurately carried out.

A syringe outer cylinder includes: an outer cylinder including: a nozzle part located at a distal end of the outer cylinder, and a locking cylindrical part covering the nozzle part; a cap attachable to and detachable from the outer cylinder; and an elastic sealing member for sealing a distal opening of the nozzle part, the elastic sealing member being housed in the cap.

The invention provides a freeze-drying material moving and taking mechanism, a double-cavity pre-filling injector production line, a production method, a control device and a storage medium. The freeze-drying material moving and taking mechanism is provided with a first feeding conveying assembly used for feeding medicinal containers, a second feeding conveying assembly used for feeding freeze-drying materials and a taking and placing assembly used for moving and taking the freeze-drying materials supplied by the second feeding conveying assembly into the medicinal containers supplied by the first feeding conveying assembly. The second feeding conveying assembly comprises a first screw and a second screw which are coaxially arranged, and the feeding state of the freeze-drying materials can be adjusted through different rotation frequencies of the first screw and the second screw. Therefore, the feeding of the freeze-drying material can be matched with the feeding of the medicinal container, so that the pre-filling and production effects of the double-cavity pre-filling injector are improved.

According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

The invention discloses a dexmedetomidine and propofol combined reagent and a combination method, and relates to the technical field of combined use of anesthetic drugs. According to the method, firstly, dexmedetomidine is subjected to intravenous pump injection within 5-15 minutes according to the dosage of 0.5-1.0 mu g / kg, propofol is given within 2 minutes after the dexmedetomidine is subjected to general anesthesia, and the dosage of the propofol can be reduced by 10%-50% compared with that of propofol which is independently used. Through pretreatment of dexmedetomidine, the anesthetic effect of propofol can be enhanced, adverse reactions such as blood pressure drop and respiratory depression can be effectively reduced, and anesthetic safety and controllability are improved. The combined reagent comprises independent containers for respectively loading the dexmedetomidine injection and the propofol emulsion, and can be packaged by adopting a double-cavity pre-filled injector, and sequential injection is realized through a controllable opening mechanism, so that unstable emulsification and titer change caused by physical mixing of medicines are avoided.

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

The invention relates to the field of injection devices, in particular to a puncture-proof protection device and a pre-filled syringe, the puncture-proof protection device comprises a medicine bin shell, a needle hiding sleeve, a needle hiding connecting rod, a connecting rod spring, a medicine bottle support, a medicine bottle gland, a needle hiding limiting piece and a pre-filled medicine bottle; the needle hiding sleeve and the needle hiding connecting rod are connected and arranged in the medicine bin shell, and the needle hiding limiting piece and the medicine bin gland are sequentially arranged at the end, away from the needle hiding sleeve, of the needle hiding connecting rod. A shifting block is arranged on the needle hiding limiting sheet; the shifting block drives the hidden needle limiting piece to rotate to limit or release the axial movement of the hidden needle connecting rod; the needle-hidden connecting rod and the pre-filled medicine bottle are sleeved in the medicine bottle bracket, and a connecting rod spring is arranged between the needle-hidden connecting rod and the medicine bottle bracket; the needle hiding sleeve is fixed by clamping the needle hiding connecting rod and the needle hiding limiting piece, so that the needle head is prevented from being exposed out of the needle hiding sleeve, and the needle head is prevented from being accidentally injured. Reset is achieved through device elasticity, the process is simple and convenient, the automation degree is high, and user operation difficulty is low.

An apparatus includes a housing, a medicament container and a movable member. The medicament container is movable within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member exerts the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member exerts a retraction force on the flange to move the medicament container from the second position towards the first position.

To efficiently manufacture a prefilled syringe.SOLUTION: In a bubble removal device 18, when a prefilled syringe 12 is positioned at the first position, an impact application unit 64 applies the first upward impact to a base end part 40 of a syringe body 22. When the prefilled syringe moves upward by receiving the first impact and a flange 32 of the syringe body contacts (collides) with a stopper 72 at the second position, the second impact is applied to the base end part of the syringe body.SELECTED DRAWING: Figure 4

1. The name of this design product: two-color prefilled syringe. 2. Purpose of this design product: for drug injection. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The utility model discloses a pre-filled syringe for sealing an infusion port tube, which can directly perform tube sealing operation after tube washing through an integrated injection structure, avoids many problems of syringe switching, avoids reverse flow of tube washing liquid or tube sealing liquid in the process, and can assist medical staff in automatically realizing a pulse type injection technique. According to the technical scheme, the catheter flushing device is characterized by comprising a pipe flushing cavity, a pipe sealing cavity and a butt joint opening, the pipe flushing cavity and the pipe sealing cavity are arranged side by side, scale marks are arranged on the outer wall of the pipe flushing cavity and the outer wall of the pipe sealing cavity, the butt joint opening is communicated with the interiors of the pipe flushing cavity and the pipe sealing cavity at the same time and can be connected to the tail end of an existing catheter, and a pipe flushing rod and a first piston are arranged at the pipe flushing cavity; a pipe sealing rod and a second piston are arranged at the position of the pipe sealing cavity, one-way valve structures are arranged between the pipe washing cavity and the butt joint opening, one-way valve structures are arranged between the pipe sealing cavity and the butt joint opening, the device further comprises a limiting piece used for limiting the displacement state of the pipe washing rod, and when the pipe washing rod moves by a specific distance, the limiting piece temporarily limits continuous movement of the pipe washing rod.

A liquid medicine administration device includes: a catheter configured to be inserted into and left in place in a living body; a tube configured to allow a liquid medicine to flow toward the catheter; a connector located at a proximal portion of the tube, the connector being selectively connectable to (i) a priming solution delivery tool configured to deliver a priming solution from a distal portion of the priming solution delivery tool, and (ii) a prefilled syringe filled with the liquid medicine; and a hollow needle located inside the connector and protruding in a proximal direction. The connector includes: a first connection portion connectable to the prefilled syringe, and a second connection portion located at a position different from the first connection portion and connectable to the priming solution delivery tool.

The present invention belongs to the technical field of medical instruments, and in particular, relates to a prefilled syringe with a protective cover, and its components, component assembly method, and drug filling method. The present invention includes a syringe, a mounting portion, and an injection needle, and also includes a protective cover unit sleeved on the syringe body, a syringe ridge arranged on the needle mounting tube and used to engage the protective cover unit, and a needle cover unit sleeved on the needle mounting tube and located in the protective cover unit, and used to release the protective cover unit from the syringe ridge in the opening direction. The needle cover unit has a technical effect of stably covering the needle to avoid exposure after the injection is completed. The advantage of the present invention is that the protective cover and the syringe are designed as an integrated unit, and the protective cover can be opened and the needle can be exposed by a one-step upward push operation. After unlocking the protective cover, the needle cover can be taken off, and the protective cover is locked with the syringe ridge when it returns to the initial position, and a ticking prompt sound is generated during the locking process of the protective cover and the syringe ridge.

An autoinjector includes a housing in which a pre-filled syringe is arranged, a drive chassis mounted in the housing, the drive chassis being biased with respect to the housing and being fixed with respect to the housing in a storage state of the autoinjector, a status indicator window and a syringe window both providing visible feedback to a user about a state of use of the autoinjector.

The disclosure relates to methods and compositions for the treatment of lupus nephritis (LN) with anti-type I IFN receptor inhibitor antibody Anifrolumab. Results of clinical trials with intravenous and subcutaneous administration of Anifrolumab. Identification of markers for LN and delivery devices and pre-filled syringe for administration of Anifrolumab.

The purpose of the present invention is to provide a pre-filled syringe formulation with staked needle, which contains an antibody at a high concentration and can be produced on an industrial scale in a simple manner without causing clogging. A pre-filled syringe formulation with staked needle, in which a protein solution is packed. The pre-filled syringe formulation is characterized in that a cap formed with a material having low water vapor permeability is provided at the needle.

The utility model relates to a needle length / depth of puncture adjusting mechanism, automatic injection device and automatic injection pen, wherein, the depth of puncture adjusting mechanism, including excitation sleeve, the bottom of excitation sleeve has the exposed end, the bottom surface of exposed end is excitation surface, and the middle of excitation surface is equipped with puncture hole, and the length of the exposed end of excitation sleeve has different length. Automatic injection device, including outer pen shell, excitation unlocking cylinder, needle retraction spring base and injection cylinder, and the length of the exposed end of excitation unlocking cylinder has different length. Automatic injection pen, including pre-filled syringe PFS, and PFS is installed in the automatic injection device as mentioned above. The utility model discloses through to the structure improvement of needle retraction spring base, in the process of pricking puncture, the needle head of PFS can move downward with the outer sleeve, and the depth of puncture pricking is controlled completely by the mechanical distance of the needle tip of needle head from excitation surface of excitation sleeve, and the depth of puncture pricking of needle head can be adjusted by selecting the excitation sleeve of different length.