50 results about "Prefilled Syringe" patented technology

The invention discloses an auxiliary device for preventing an injector from needling. The auxiliary device aims to solve the problems that an existing passive protection device is prone to being started by mistake, a push rod is prone to inclining, protection is not achieved after injection, and adaptability is poor. The device comprises an outer shell, a compression spring, an inner shell, a disposable prefilled syringe and a push rod. The shell is an external support and is provided with a guide bone position, an elastic step, a guide channel, an elastic buckle and the like; the inner shell is assembled in the outer shell, bears the injector and is connected with the compression spring; the push rod is in threaded connection with the syringe piston, and the actuating rod is inserted into the shell guide channel. The device realizes single-hand operation and automatic protection, does not need an additional activation step, is adaptive to a medicine production process, effectively reduces the risk of pricking injury, and avoids waste of liquid medicine. And the clinical use safety and the operation convenience are improved.

The invention relates to the technical field of medicine packing materials, in particular to a filling process of a novel aripiprazole double-cavity pre-filling syringe, and a syringe barrel of the novel double-cavity pre-filling syringe is made of COP / COC materials; comprising the following steps of sterilization, middle plug placement, sterile filling, freeze drying, plug pressing and assembling, and a complete double-cavity pre-filled syringe is obtained.The filling process combines high strength and heat conduction uniformity of COP / COC materials, in-situ freeze-drying in the syringe is achieved, the step of powder transfer after freeze-drying of a traditional penicillin bottle is avoided, and the production efficiency is improved. According to the present invention, the sterile risk and the production cost are significantly reduced, the manufacturing process is simplified, the equipment complexity and the product loss are reduced, and the high dose accuracy and the yield are ensured.

A prefilled syringe safety device and injector for use with a syringe. The prefilled syringe safety device and injector includes a cartridge, a casing, a tube, a biasing member, a ring, and a plunger slider. The cartridge supports the syringe. The cartridge is supported within the casing. The tube includes a tube distal end. The tube is slidably engaged with the cartridge and can be in an extended state and in a retracted state. When in the retracted state, the needle of the syringe extends beyond the tube distal end and the casing distal opening. The biasing member is engaged with the cartridge and the tube to bias the tube in the extended state. The ring includes a protrusion and is engaged with the tube and the biasing member. The protrusion is positioned within the track. The plunger slider extends from the plunger of the syringe.

Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

The invention discloses a prefilled syringe glass needle cylinder flange width cutting device which comprises a base, an X-direction displacement mechanism is installed on the base, a Y-direction displacement mechanism is installed on the X-direction displacement mechanism, a motor support is installed on the Y-direction displacement mechanism, a servo motor, a speed reducer and a transmission shaft are installed on the motor support, and a double-face cam is installed at the tail end of the transmission shaft. The double-face cam comprises a disc-shaped wheel, cam-shaped grooves are formed in the two side faces of the disc-shaped wheel respectively, cam-shaped protrusions with different cam curves are arranged in the cam-shaped grooves respectively, cam curve grooves are formed between the outer contours of the cam-shaped grooves and the outer contours of the cam-shaped protrusions, a left cam curve groove is formed in the left side face of the disc-shaped wheel, and a right cam curve groove is formed in the right side face of the disc-shaped wheel. A right cam curve groove is formed in the right side face of the disc-shaped wheel, and a stroke difference exists between the left cam curve groove and the right cam curve groove. The end face and the two side faces of the glass needle cylinder are machined at the same time through the driving device through the design of the cam curve groove of a special structure and the compact sliding type design.

A medical container and a method for manufacturing the medical container. The medical container (1) includes a barrel defining a reservoir for containing a medical product and a needle (4) extending into a barrel channel (24) at a distal end (20) of the barrel to establish fluid communication between the reservoir and the needle (4). The medical container (1) further includes an on-metal RFID (ROM) tag (8), the on-metal RFID (ROM) tag (8) being at least partially disposed within the barrel channel (24) and having an antenna (82) extending along the needle (4).

Devices and methods are disclosed herein for a tamper evident and tamper resistant device for a syringe. The small size of the device reduces costs related to production as well as preserves space in medical carts or other medical storage areas. The device includes two ends connected via a shaft. The two ends are shaped to be complementary to each end of the syringe, particularly to cover the ends of a pre-filled syringe to prevent access for potential tampering. Also disclosed is a wrapper and method of wrapping the device and the syringe where removal of the wrapping or attempted access to the syringe provides evidence of tampering. The wrapping can also be perforated to allow for ease of removal during actual intended use of the pre-filled syringe.

A method of treating an eye disorder in a patient that may include administering a medicament to the patient with a prefilled syringe, wherein the administration of the medicament with the prefilled syringe is configured to treat the eye disorder and decrease a rate of likelihood of an ocular infection to the patient's eye.

The present invention relates to a silicone-oil-free prefilled syringe and a method for manufacturing same. The silicone-oil-free prefilled syringe of the present invention is in a form coated with an acrylate-based amphoteric material containing a phosphorylcholine group, which is a super-hydrophilic material having excellent biocompatibility, on a rubber gasket of a syringe plunger, and has the advantages of being simply manufactured and overcoming physical and biological problems of existing silicone-oil-coated prefilled syringes.

The present invention is concerned with an operating assembly (1) and with a computer implemented method for a prefilled syringe (7) comprising: - a fixture (2) to accommodate the prefilled syringe (7), - a plunger rod (6) operatively coupled to the fixture (2 - a data acquisition unit (20) accommodated either by the fixture (2) or the plunger rod (6), - at least two interaction structures (11, 12), whereby one of the interaction structures is provided by the fixture (2) and the other by the plunger rod (6), wherein the interaction structures (11, 12) are mutually shaped and arranged in such a way a frictional force may act between them which occurs repeatedly during an ejection stroke wherein the acceleration and the speed of both the fixture (2) and the plunger rod (6) are modulated accordingly, wherein the data acquisition unit (20) captures a signal (27) evoked by said modulated speed and acceleration.

The present invention relates to an RDID tag enabled needle shield assembly that provides a sterile enclosure of an injection needle and that can be fixedly attached to a pre-filled syringe for administering an injection of medicament to a patient after removal of the needle shield assembly. The RFID tag is fixedly attached to the needle shield through co-molding or another form of permanent attachment. The present invention also relates to a method of tracking the life cycle of a medicament injection device where the RFID tag enabled needle shield assembly is attached to an injection needle that is connected to a syringe barrel that is part of an injection device. Data is written to or read from the RFID tag during the entire life cycle of the injection device, including assembly, packaging, storing, distribution and use.

A system for measuring an air gap in a syringe having a plunger and containing a fluid of the present disclosure may include one or more processors configured to control a syringe imaging device to capture a first image of at least a portion of the syringe with the syringe imaging device oriented at a first rotational angle around a central syringe axis of the syringe with respect to a first central imaging axis of the syringe imaging device. The one or more processors may also be configured to control the syringe imaging device to capture a second image of at least a portion of the syringe with the syringe imaging device oriented at a second rotational angle around the central syringe axis with respect to a second central imaging axis. The one or more processors may be further configured to determine an air gap measurement between the plunger and fluid by analyzing at least the first image and the second image.

Provided herein is a system including an IV catheter assembly with a catheter having a distal end positionable intravenously within a patient and a port providing fluid access to the catheter. The system also includes a pre-filled syringe connectable to the port and that contains an aqueous catheter lock solution having magnetic particles suspended therein. The system further includes a probe module comprising a magnetic probe that includes a magnet element and a driver. The magnetic probe is operable in a first driving mode where the magnet element causes the magnetic nanoparticles to migrate towards the distal end of the catheter and is operable in a second driving mode where the magnet element causes a temperature of the magnetic nanoparticles to increase, generating a magnetically-induced hyperthermic condition at the distal end of the catheter that prevents and / or treats thrombus formation and biofilm accumulation in the catheter.

The utility model discloses a glass needle tube tray for a prefilled syringe, which belongs to the technical field of trays and comprises a tray body and a glass needle tube, reinforcing ribs are arranged in the tray body, a plurality of placing grooves are arranged at the center of the tray body, through holes are arranged above the placing grooves, and the glass needle tube is arranged in the tray body. The containing groove comprises a supporting part at the bottom, limiting parts on the two sides and a groove in the head, the shape of the supporting part is matched with the outline of the glass needle tube, a spiral head is arranged at the top of the glass needle tube, and a handle is arranged at the bottom of the glass needle tube. Through mutual cooperation of the placing groove, the tray body, the supporting part, the limiting part, the groove, the glass needle tube, the first limiting surface, the limiting block, the handle and the spiral head, the glass needle tube can be limited and protected, so that the glass needle tube is prevented from being damaged due to shaking and collision in the transferring process; and therefore, the safety in the transportation process is improved.

1. The name of the design product: pre-filled syringe. 2. The use of the design product: for medical injection. 3. The design points of the design product: the shape, and the transparent material of part A. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains colors.

The invention discloses a thermodynamic process control method for a glass needle tube for a pre-filled syringe, and particularly relates to the technical field of production of glass for medicine for the pre-filled syringe. Comprising the steps of multi-modal sensing configuration and calibration of a pre-filled glass product, multi-modal sensing fusion and thermodynamic state estimation of a glass needle tube for a pre-filled syringe, online correction and working condition identification of a digital twin model of the pre-filled glass product, and self-adaptive control decision of a thermodynamic process of the pre-filled glass product. Based on an execution and feedback step of a double-stage high-temperature regulation and control process of the pre-encapsulated glass product and a historical data archiving and self-learning optimization step of a thermodynamic process of the pre-encapsulated glass product, multi-source sensing data fusion and linkage of a digital twin model and a reinforcement learning control strategy are utilized; the whole-process refined and intelligent control of the double-stage high-temperature regulation and control process of the pre-encapsulated glass product is realized.

The present invention relates to a novel liquid pharmaceutical composition of Adalimumab comprising Adalimumab or its biosimilars, an acetate buffer / system such as sodium acetate / acetic acid and a sugar stabilizer such as trehalose. The combination of components results in a formulation with stability (e.g. upon storage and upon contact stress) comparable to those known in the art and with fewer ingredients. This advantage helps the availability of Adalimumab therapy to become more widespread at a minimum cost and extends the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary drug waste.

This invention provides a pre-filled syringe, including a barrel containing a piston and a push rod. A flange is located at the rear end of the barrel, and a push handle is mounted on the flange. The push handle engages with the flange via a slot with a side opening, and the upper and lower sides of the slot communicate with an upper through slot and a lower through slot, respectively. A push plate abuts against the piston at the front end of the push rod. The push rod is configured such that its shaft can pass through the upper through slot, but its push plate cannot. This eliminates the need for a complex connection between the push plate and the piston; they simply abut against each other, simplifying manufacturing and assembly and reducing costs. The push plate can push the piston forward but cannot pull it back, preventing repeated use of the syringe and the resulting medical waste contamination. Furthermore, the upper through slot of the push handle restricts the push plate's passage, ensuring the push rod does not detach from the barrel during transport, resulting in better performance.

Avacincaptad pegol, also known under the trademarks Izervay or Zimura, is a molecule comprising an aptamer sequence and a polyethylene glycol polymer (PEG) -moiety. The aptamer sequence binds to complement C5-protein, which C5 protein is known to be involved in many eye diseases. Avacincaptad pegol is approved to treat Age-related Macular Degeneration (AMD) secondary to Geographic Atrophy (GA) and is applied by intravitreal injection into the eye. The pharmaceutical product is currently only offered as a liquid in a vial. This patent application discloses Avacincaptad in a more stable presentation, namely in a pre-filled syringe, which surprisingly results in very significantly improved stability of the product.

The present invention relates to a buffered protein containing formulation comprising as stabilizing ingredient an amphiphilic surfactant. Said surfactant is formed by polyalkoxylating an a-tocopherol compound. The polyalkoxy residue is either a block copolymer or a statistical or random copolymer composed of a majority of ethylene oxide moieties and a smaller amount of propylene oxide and / or butylene oxide moieties. Said surfactant significantly improves stability, in particular aggregation stability of the protein formulation, while showing low hemolytic activity and good water solubility. Said surfactant is particularly suitable for preparing stabilized formulations of enzymes and immunoglobulin molecules as well as adducts and conjugates comprising such biomolecules. Said formulations may be provided in liquid or dry form and are suitable for the preparation of pharmaceutical compositions. According to another aspect of the invention the use of such formulations in medicine, in particular for diagnostic and / or therapeutic applications is provided. The present invention also relates to a method of preparing such formulations as well as a method for preparing such specific amphiphilic surfactants. According to a further aspect a method for preventing or suppressing protein aggregation of a liquid protein containing formulation in vitro by using an amphiphilic surfactant of the present invention as a stabilizer is provided. A prefilled syringe, comprising a reservoir prefilled with an amount of a formulation of the invention constitutes another aspect of the invention.

Automatic prefilled syringe inspection systems, apparatus and methods are provided. The automatic syringe inspection systems, apparatus and methods may determine a plunger depth within a syringe that has been pre-filled with a medication. The plunger depth may be based on digital image data that is representative of a silhouette of at least a portion of a tubular vessel and at least a portion of a plunger within the tubular vessel.

A prefilled syringe is provided with a fixation clip that, once applied, prevents longitudinal movement of a plunger within a syringe barrel, thereby providing for fixation of the stopper inside the barrel to assure preservation of container closure integrity and maintaining the sterility of the syringe content during conditions such as cold storage and transport, or transport with significant pressure change such as air transport. The fixation clip may include notches thereon accepting a corresponding number of ridges formed on the plunger rod, or alternatively may be formed with an internal cavity to allow sliding over a syringe barrel flange and snapping thereon, and presenting patterns such as protrusions or stops so as to lock the plunger rod, the stopper, and the syringe barrel together. Rotation of the plunger rod up to the desired location liberates the plunger and allows conventional dispensing of medical liquid from the syringe assembly.

The utility model discloses a safety device for a prefilled syringe and an injection device, and relates to the technical field of medical equipment, in order to solve the problem that an existing safety device is not high in safety, the safety device comprises an outer cylinder, a sliding groove extending in the axial direction of the outer cylinder is formed in the inner wall of the outer cylinder, and limiting holes are formed in the two ends of the sliding groove; the protective cover is arranged in the outer cylinder, a positioning pin is arranged at the end, movably connected with the outer cylinder, of the protective cover and matched with the limiting hole and the sliding groove, the outer cylinder is rotationally sleeved with the handle structure, a starting button used for enabling the positioning pin to be separated from the limiting hole is arranged on the handle structure, and the elastic piece is arranged between the outer cylinder and the protective cover. The elastic piece is used for providing pre-tightening force enabling the protective cover to move in the direction extending out of the outer cylinder, triggering is conducted in an active rotating and pressing mode, so that the safety device before triggering is not prone to triggering failure caused by collision, and meanwhile through cooperation of the limiting hole and the positioning pin, it can be guaranteed that the safety device after triggering is locked and not prone to failure.

According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

This medical container includes a barrel defining a reservoir for containing a medical product, and a needle extending in a barrel channel provided at a distal end of the barrel so as to establish a fluid communication between the reservoir and the needle. The medical container further includes a RFID on-metal (ROM) tag, said RFID on-metal tag being located at least partly inside the barrel channel and having an antenna extending along the needle.

The invention relates to the technical field of pre-filling syringe production, in particular to a novel aripiprazole double-cavity pre-filling syringe freeze-drying groove frame and a using method thereof.The novel aripiprazole double-cavity pre-filling syringe freeze-drying groove frame comprises a groove frame plate, the lower surface of the groove frame plate protrudes downwards to form a plurality of hollow nest barrels, and the groove frame plate is provided with containing openings matched with the nest barrels; according to the invention, the lower surface of the groove frame plate protrudes downwards to form a plurality of hollow nest cylinders, and the nest cylinders are matched with the placing ports on the groove frame plate, so that the structure creates a special and stable placing space for the aripiprazole double-cavity pre-filled injector; due to the fact that the inner hollow structure of the nest cylinder is matched with the appearance of the injector, the injector can be firmly fixed after being placed in the nest cylinder, the situation that the injector shakes or inclines is avoided, and therefore the phenomenon that in the transferring process, the injector is damaged due to collision or the adverse effect on the freeze-drying process is caused due to position deviation is effectively avoided.

An apparatus includes a housing, a carrier, a medicament container, and a flexible member. The housing defines an opening placing a gas chamber of the housing in fluid communication with an exterior volume. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container containing a medicament and includes an elastomeric member that seals the medicament therein. The flexible member has a distal end portion coupled to the elastomeric member and a proximal end portion coupled to a valve member. The flexible member transitions from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container. The flexible member moves the valve member relative to the opening when the flexible member transitions from the collapsed configuration to the expanded configuration.

What is disclosed is a medication delivery device and methods of use thereof to provide visual indication of a completion of an injection event. The device can have a container retraction mechanism coupled to a medication container, such as a prefilled syringe, by which when triggered the container is retracted distally within the housing after the medication is forced from the container outlet. The container retraction mechanism includes one or more retraction component(s) that facilitate the retraction process. The retraction component can stop at a start of retraction or start moving during retraction. One or more windows are provided along the housing, such as, being formed by a label. The container and / or the retraction component includes a visual indicator that is visual through the window as indication of a completion of injection. The window may be distal to the visual indicator prior to the retraction process.

A needle cylinder is formed by connecting a front cylinder body and a rear cylinder body in a sealed mode, a front end sealing cap is detachably installed on a Luer taper at the front end of the front cylinder body, and a push rod piston and a middle sealing piston are sequentially arranged in a needle cylinder cavity in a sliding mode. The middle sealing piston divides the needle cylinder cavity into a liquid medicine storage cavity and a powder storage cavity, a bypass structural surface with a bypass groove is formed on the inner wall of the needle cylinder cavity, an axial blocking convex rib is arranged in the middle of the bypass structural surface, and in the liquid medicine mixing stage, the middle sealing piston is blocked by the axial blocking convex rib and kept positioned; the middle sealing piston can respond to the thrust of the push rod piston, cross over the blocking convex rib and enter a medicine injection stage, the front end sealing cap comprises a shell, one end of an assembly shell part of the shell is provided with an insertion part, the other end of the assembly shell part is provided with an exhaust port opened and closed through a sealing end cover, and a filter element component for achieving liquid stopping and exhaust is arranged in an installation cavity of the assembly shell part. The medicine mixing operation is safe, reliable and convenient.