92 results about "Prefilled Syringe" patented technology

The invention discloses an auxiliary device for preventing an injector from needling. The auxiliary device aims to solve the problems that an existing passive protection device is prone to being started by mistake, a push rod is prone to inclining, protection is not achieved after injection, and adaptability is poor. The device comprises an outer shell, a compression spring, an inner shell, a disposable prefilled syringe and a push rod. The shell is an external support and is provided with a guide bone position, an elastic step, a guide channel, an elastic buckle and the like; the inner shell is assembled in the outer shell, bears the injector and is connected with the compression spring; the push rod is in threaded connection with the syringe piston, and the actuating rod is inserted into the shell guide channel. The device realizes single-hand operation and automatic protection, does not need an additional activation step, is adaptive to a medicine production process, effectively reduces the risk of pricking injury, and avoids waste of liquid medicine. And the clinical use safety and the operation convenience are improved.

The invention relates to the technical field of medicine packing materials, in particular to a filling process of a novel aripiprazole double-cavity pre-filling syringe, and a syringe barrel of the novel double-cavity pre-filling syringe is made of COP / COC materials; comprising the following steps of sterilization, middle plug placement, sterile filling, freeze drying, plug pressing and assembling, and a complete double-cavity pre-filled syringe is obtained.The filling process combines high strength and heat conduction uniformity of COP / COC materials, in-situ freeze-drying in the syringe is achieved, the step of powder transfer after freeze-drying of a traditional penicillin bottle is avoided, and the production efficiency is improved. According to the present invention, the sterile risk and the production cost are significantly reduced, the manufacturing process is simplified, the equipment complexity and the product loss are reduced, and the high dose accuracy and the yield are ensured.

The device includes a housing, a gas container, a drug container assembly, and a movable seal member, the housing defining a gas chamber and an equalization bypass. The gas container is disposed within the housing and configured to generate pressurized gas in the gas chamber when the device is activated. The movable seal member is configured to move from a first sealing position to a second sealing position. When the movable seal member is in the first sealing position, the gas chamber is in fluid communication with an external volume surrounding the device via the equalization bypass. When the movable seal member is in the second sealing position, the gas chamber is fluidly isolated from the external volume by the movable seal member.

A prefilled syringe safety device and injector for use with a syringe. The prefilled syringe safety device and injector includes a cartridge, a casing, a tube, a biasing member, a ring, and a plunger slider. The cartridge supports the syringe. The cartridge is supported within the casing. The tube includes a tube distal end. The tube is slidably engaged with the cartridge and can be in an extended state and in a retracted state. When in the retracted state, the needle of the syringe extends beyond the tube distal end and the casing distal opening. The biasing member is engaged with the cartridge and the tube to bias the tube in the extended state. The ring includes a protrusion and is engaged with the tube and the biasing member. The protrusion is positioned within the track. The plunger slider extends from the plunger of the syringe.

Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

The invention discloses a prefilled syringe glass needle cylinder flange width cutting device which comprises a base, an X-direction displacement mechanism is installed on the base, a Y-direction displacement mechanism is installed on the X-direction displacement mechanism, a motor support is installed on the Y-direction displacement mechanism, a servo motor, a speed reducer and a transmission shaft are installed on the motor support, and a double-face cam is installed at the tail end of the transmission shaft. The double-face cam comprises a disc-shaped wheel, cam-shaped grooves are formed in the two side faces of the disc-shaped wheel respectively, cam-shaped protrusions with different cam curves are arranged in the cam-shaped grooves respectively, cam curve grooves are formed between the outer contours of the cam-shaped grooves and the outer contours of the cam-shaped protrusions, a left cam curve groove is formed in the left side face of the disc-shaped wheel, and a right cam curve groove is formed in the right side face of the disc-shaped wheel. A right cam curve groove is formed in the right side face of the disc-shaped wheel, and a stroke difference exists between the left cam curve groove and the right cam curve groove. The end face and the two side faces of the glass needle cylinder are machined at the same time through the driving device through the design of the cam curve groove of a special structure and the compact sliding type design.

A medical container and a method for manufacturing the medical container. The medical container (1) includes a barrel defining a reservoir for containing a medical product and a needle (4) extending into a barrel channel (24) at a distal end (20) of the barrel to establish fluid communication between the reservoir and the needle (4). The medical container (1) further includes an on-metal RFID (ROM) tag (8), the on-metal RFID (ROM) tag (8) being at least partially disposed within the barrel channel (24) and having an antenna (82) extending along the needle (4).

Devices and methods are disclosed herein for a tamper evident and tamper resistant device for a syringe. The small size of the device reduces costs related to production as well as preserves space in medical carts or other medical storage areas. The device includes two ends connected via a shaft. The two ends are shaped to be complementary to each end of the syringe, particularly to cover the ends of a pre-filled syringe to prevent access for potential tampering. Also disclosed is a wrapper and method of wrapping the device and the syringe where removal of the wrapping or attempted access to the syringe provides evidence of tampering. The wrapping can also be perforated to allow for ease of removal during actual intended use of the pre-filled syringe.

A method of treating an eye disorder in a patient that may include administering a medicament to the patient with a prefilled syringe, wherein the administration of the medicament with the prefilled syringe is configured to treat the eye disorder and decrease a rate of likelihood of an ocular infection to the patient's eye.

A method is used to manufacture a prefilled glass syringe containing a sterile pharmaceutical composition of rocuronium bromide. The prefilled syringe containing the sterile pharmaceutical composition of rocuronium bromide can be part of a kit. The sterile pharmaceutical composition of rocuronium bromide can include at least one stabilizer, a buffer system, a tonicity agent, and water. Prefilled syringes containing the sterile pharmaceutical composition of rocuronium bromide can be storage-stable for extended periods of time at room temperature.

The present invention relates to a silicone-oil-free prefilled syringe and a method for manufacturing same. The silicone-oil-free prefilled syringe of the present invention is in a form coated with an acrylate-based amphoteric material containing a phosphorylcholine group, which is a super-hydrophilic material having excellent biocompatibility, on a rubber gasket of a syringe plunger, and has the advantages of being simply manufactured and overcoming physical and biological problems of existing silicone-oil-coated prefilled syringes.

The present invention is concerned with an operating assembly (1) and with a computer implemented method for a prefilled syringe (7) comprising: - a fixture (2) to accommodate the prefilled syringe (7), - a plunger rod (6) operatively coupled to the fixture (2 - a data acquisition unit (20) accommodated either by the fixture (2) or the plunger rod (6), - at least two interaction structures (11, 12), whereby one of the interaction structures is provided by the fixture (2) and the other by the plunger rod (6), wherein the interaction structures (11, 12) are mutually shaped and arranged in such a way a frictional force may act between them which occurs repeatedly during an ejection stroke wherein the acceleration and the speed of both the fixture (2) and the plunger rod (6) are modulated accordingly, wherein the data acquisition unit (20) captures a signal (27) evoked by said modulated speed and acceleration.

The present invention relates to an RDID tag enabled needle shield assembly that provides a sterile enclosure of an injection needle and that can be fixedly attached to a pre-filled syringe for administering an injection of medicament to a patient after removal of the needle shield assembly. The RFID tag is fixedly attached to the needle shield through co-molding or another form of permanent attachment. The present invention also relates to a method of tracking the life cycle of a medicament injection device where the RFID tag enabled needle shield assembly is attached to an injection needle that is connected to a syringe barrel that is part of an injection device. Data is written to or read from the RFID tag during the entire life cycle of the injection device, including assembly, packaging, storing, distribution and use.

A system for measuring an air gap in a syringe having a plunger and containing a fluid of the present disclosure may include one or more processors configured to control a syringe imaging device to capture a first image of at least a portion of the syringe with the syringe imaging device oriented at a first rotational angle around a central syringe axis of the syringe with respect to a first central imaging axis of the syringe imaging device. The one or more processors may also be configured to control the syringe imaging device to capture a second image of at least a portion of the syringe with the syringe imaging device oriented at a second rotational angle around the central syringe axis with respect to a second central imaging axis. The one or more processors may be further configured to determine an air gap measurement between the plunger and fluid by analyzing at least the first image and the second image.

Provided herein is a system including an IV catheter assembly with a catheter having a distal end positionable intravenously within a patient and a port providing fluid access to the catheter. The system also includes a pre-filled syringe connectable to the port and that contains an aqueous catheter lock solution having magnetic particles suspended therein. The system further includes a probe module comprising a magnetic probe that includes a magnet element and a driver. The magnetic probe is operable in a first driving mode where the magnet element causes the magnetic nanoparticles to migrate towards the distal end of the catheter and is operable in a second driving mode where the magnet element causes a temperature of the magnetic nanoparticles to increase, generating a magnetically-induced hyperthermic condition at the distal end of the catheter that prevents and / or treats thrombus formation and biofilm accumulation in the catheter.

A prefilled syringe is disclosed that includes a barrel, a stopper displaceable within and defining a sealed chamber in an interior of the barrel, a liquid filled in the chamber of the barrel, and a plunger extending within the barrel. The stopper expels the liquid out of the barrel via an orifice when being forwarded towards the orifice by the plunger such that a volume of the chamber is reduced. The plunger includes a proximal portion, a distal portion and a rod portion extending between the proximal portion and the distal portion. The plunger is shaped to form a pathway between an opening of the barrel and a segment where the proximal portion of the plunger is neighboring the stopper such that a sterilizing agent can be provided through the opening of the barrel to the segment where the proximal portion of the plunger is neighboring the stopper.

Kits and methods may be for treatments with olanzapine or a pharmaceutically acceptable salt thereof. The kit may include a container; at least one tray disposed in the container; a pre-filled syringe containing a diluent comprising a biodegradable polymer excipient, the pre-filled syringe being disposed in a first compartment of the tray; a vial containing a medicament comprising olanzapine, the vial being disposed in a second compartment of the tray; a dosing syringe configured to administer the medicament, the dosing syringe being disposed in a third compartment of the tray; a dosing needle configured to be attached to the dosing syringe, the dosing needle being disposed in a fourth compartment of the tray; a first indicia on the tray corresponding to the first compartment; and a second indicia on the tray corresponding to the second compartment, wherein the second indicia is different than the first indicia. The kit may include a warming pack, and methods of use may include warming the diluent from a substantially solid state using the warming pack. The diluent may further comprise an organic solvent such as dimethyl sulfoxide. The diluent may be transferred to the vial to reconstitute the medicament, and the reconstituted medicament may be stored for up to 24 hours before use.

To provide a technique capable of detecting an assembly failure of a pre-filled syringe to be attached to a syringe pump.SOLUTION: A syringe pump comprises: a potentiometer 170 that detects a position of a slider 120; an arithmetic unit 151 that controls movement of the slider 120; and a memory 152 that stores a reference position of a pre-filled syringe 10 when the pre-filled syringe 10 is properly attached. The arithmetic unit 151 determines an assembly failure of a barrel 20 and a plunger rod 30 based on a position of the slider 120 detected by the potentiometer 170 when the pre-filled syringe 10 is attached, and the reference position stored in the memory 152.SELECTED DRAWING: Figure 8

The prefilled syringe is provided with a locking clip, which, when attached, prevents longitudinal movement of the plunger within the syringe barrel, thereby securing the stopper within the barrel to ensure the integrity of the container closure and maintain the sterility of the syringe contents during conditions such as refrigeration and transportation, or transportation involving large pressure changes, such as air transportation. The locking clip may include notches on the locking clip that receive a corresponding number of bumps formed on the plunger rod, or may be formed with an internal cavity to allow it to slide over and snap onto the flange of the syringe barrel, displaying a pattern of bumps or stoppers to secure the plunger rod, stopper, and syringe barrel together. Rotation of the plunger rod to the desired position releases the plunger, allowing normal administration of the medical liquid from the syringe assembly.

The utility model discloses a glass needle tube tray for a prefilled syringe, which belongs to the technical field of trays and comprises a tray body and a glass needle tube, reinforcing ribs are arranged in the tray body, a plurality of placing grooves are arranged at the center of the tray body, through holes are arranged above the placing grooves, and the glass needle tube is arranged in the tray body. The containing groove comprises a supporting part at the bottom, limiting parts on the two sides and a groove in the head, the shape of the supporting part is matched with the outline of the glass needle tube, a spiral head is arranged at the top of the glass needle tube, and a handle is arranged at the bottom of the glass needle tube. Through mutual cooperation of the placing groove, the tray body, the supporting part, the limiting part, the groove, the glass needle tube, the first limiting surface, the limiting block, the handle and the spiral head, the glass needle tube can be limited and protected, so that the glass needle tube is prevented from being damaged due to shaking and collision in the transferring process; and therefore, the safety in the transportation process is improved.

The utility model provides a tool for sterilizing pre-filled injectors, which belongs to the technical field of sterilization of pre-filled injectors and comprises a horizontally arranged tool box body with an upward opening, and the interior of the tool box body is sequentially divided into three placing areas from front to back through horizontally arranged partition plates. The tool comprises a tool box body, a placing area is arranged on the upper side of the tool box body, a supporting plate for placing a pre-filled syringe is horizontally arranged on the upper side of the placing area, the left end and the right end of the supporting plate are fixedly connected with the left side and the right side of the upper surface of the tool box body respectively, a clamping assembly is arranged on the supporting plate, and a driving assembly is arranged in the tool box body. The problems that other tools are inconvenient to take and low in efficiency are solved; other tools cannot be adjusted and are not suitable for pre-filling and sealing injectors of different models and specifications; other tools are high in height, large in size and large in occupied space, and when a prefilled syringe is placed in a general vertical type, the prefilled syringe is prone to falling down and breaking due to misalignment.

1. The name of the design product: pre-filled syringe. 2. The use of the design product: for medical injection. 3. The design points of the design product: the shape, and the transparent material of part A. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains colors.

The invention discloses a thermodynamic process control method for a glass needle tube for a pre-filled syringe, and particularly relates to the technical field of production of glass for medicine for the pre-filled syringe. Comprising the steps of multi-modal sensing configuration and calibration of a pre-filled glass product, multi-modal sensing fusion and thermodynamic state estimation of a glass needle tube for a pre-filled syringe, online correction and working condition identification of a digital twin model of the pre-filled glass product, and self-adaptive control decision of a thermodynamic process of the pre-filled glass product. Based on an execution and feedback step of a double-stage high-temperature regulation and control process of the pre-encapsulated glass product and a historical data archiving and self-learning optimization step of a thermodynamic process of the pre-encapsulated glass product, multi-source sensing data fusion and linkage of a digital twin model and a reinforcement learning control strategy are utilized; the whole-process refined and intelligent control of the double-stage high-temperature regulation and control process of the pre-encapsulated glass product is realized.

The present invention relates to a novel liquid pharmaceutical composition of Adalimumab comprising Adalimumab or its biosimilars, an acetate buffer / system such as sodium acetate / acetic acid and a sugar stabilizer such as trehalose. The combination of components results in a formulation with stability (e.g. upon storage and upon contact stress) comparable to those known in the art and with fewer ingredients. This advantage helps the availability of Adalimumab therapy to become more widespread at a minimum cost and extends the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary drug waste.

Provided is a pre-filled syringe that can inhibit protein aggregation in a protein solution formulation while also reducing the produced amount of a decomposition product of a non-ionic surfactant after long-term storage. The pre-filled syringe includes: a barrel formed of a resin containing a hydrogenated cycloolefin ring-opened polymer and / or a copolymer of a cycloolefin and a chain olefin; a sealing member sealing a nozzle of the barrel; a gasket housed inside the barrel; and a plunger performing a movement operation of the gasket, and contains a protein solution formulation in a space defined by the sealing member, the gasket, and a region that is part of an inner wall surface of the barrel. The protein solution formulation has a non-ionic surfactant concentration of more than 0 mg / mL and less than 0.05 mg / mL.

This invention provides a pre-filled syringe, including a barrel containing a piston and a push rod. A flange is located at the rear end of the barrel, and a push handle is mounted on the flange. The push handle engages with the flange via a slot with a side opening, and the upper and lower sides of the slot communicate with an upper through slot and a lower through slot, respectively. A push plate abuts against the piston at the front end of the push rod. The push rod is configured such that its shaft can pass through the upper through slot, but its push plate cannot. This eliminates the need for a complex connection between the push plate and the piston; they simply abut against each other, simplifying manufacturing and assembly and reducing costs. The push plate can push the piston forward but cannot pull it back, preventing repeated use of the syringe and the resulting medical waste contamination. Furthermore, the upper through slot of the push handle restricts the push plate's passage, ensuring the push rod does not detach from the barrel during transport, resulting in better performance.

Avacincaptad pegol, also known under the trademarks Izervay or Zimura, is a molecule comprising an aptamer sequence and a polyethylene glycol polymer (PEG) -moiety. The aptamer sequence binds to complement C5-protein, which C5 protein is known to be involved in many eye diseases. Avacincaptad pegol is approved to treat Age-related Macular Degeneration (AMD) secondary to Geographic Atrophy (GA) and is applied by intravitreal injection into the eye. The pharmaceutical product is currently only offered as a liquid in a vial. This patent application discloses Avacincaptad in a more stable presentation, namely in a pre-filled syringe, which surprisingly results in very significantly improved stability of the product.

1. Name of the product under this design: Prefilled syringe (1‑20ml cut edge). 2. Purpose of this design product: This design product is used for medical injections, cosmetic containers, hyaluronic acid injection containers, etc. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The present invention relates to a buffered protein containing formulation comprising as stabilizing ingredient an amphiphilic surfactant. Said surfactant is formed by polyalkoxylating an a-tocopherol compound. The polyalkoxy residue is either a block copolymer or a statistical or random copolymer composed of a majority of ethylene oxide moieties and a smaller amount of propylene oxide and / or butylene oxide moieties. Said surfactant significantly improves stability, in particular aggregation stability of the protein formulation, while showing low hemolytic activity and good water solubility. Said surfactant is particularly suitable for preparing stabilized formulations of enzymes and immunoglobulin molecules as well as adducts and conjugates comprising such biomolecules. Said formulations may be provided in liquid or dry form and are suitable for the preparation of pharmaceutical compositions. According to another aspect of the invention the use of such formulations in medicine, in particular for diagnostic and / or therapeutic applications is provided. The present invention also relates to a method of preparing such formulations as well as a method for preparing such specific amphiphilic surfactants. According to a further aspect a method for preventing or suppressing protein aggregation of a liquid protein containing formulation in vitro by using an amphiphilic surfactant of the present invention as a stabilizer is provided. A prefilled syringe, comprising a reservoir prefilled with an amount of a formulation of the invention constitutes another aspect of the invention.