278results about How to "Improvement of side effects" patented technology

The present invention is directed to improved formulations for dihydroergotamine in which the drug is present at a concentration of at least 2.9 mM. The invention encompasses methods for using these formulations in treating patients for migraine headaches and the packaging of formulation into prefilled syringes for self-administration by patients.

The invention discloses a human immunodeficiency virus (HIV) affinity adsorption column, comprising a column body and at least one activated affinity microsphere located in the column body, wherein the activated affinity microsphere is connected with a human immunodeficiency virus affinity protein, and the affinity protein can be bound with human immunodeficiency virus. The affinity protein comprises a main receptor CD4 molecule, a gp120 antibody, an auxiliary receptor CXC chemokine receptor 4 (CXCR-4) and a CC chemokine receptor 5 (CCR-5). The affinity microsphere may be a glass microsphere with the size of 1mm, a chitosan crosslinking microsphere with the diameter more than 500 microns, or a gluosan microsphere. The human immunodeficiency virus affinity adsorption column disclosed by the invention is applicable for eliminating the human immunodeficiency virus in the blood of HIV patients, and relieving and treating the immunodeficiency syndrome of HIV patients; and compared with the traditional treatment methods, the immunoadsorption column has high safety, good specificity, small toxic or side effects and good operation simplicity.

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

The invention belongs to a liposome, in particular relates to a compound liposome preparation with high targeting property of tumor tissues and efficient penetrability of tumor cells. The invention is characterized in that hyaluronic acid or sodium hyaluronate, tumor cell selective penetrating peptides and a liposome are used for together constructing a compound liposome. The compound liposome is characterized by utilizing the dual-tumor cell targeting property of the hyaluronic acid and tumor cell selective penetrating peptides to effectively solve the problem that because a conventional liposome and traditional cell penetrating peptides have no selectivity on normal cells and tumor cells, the toxicity is increased when the drug effect is increased in the therapeutic process, thereby fully meeting the clinical requirements of high efficiency and low toxicity when anti-tumor drugs are prepared into preparations for treating diseases.

The invention relates to a green premixed feedstuff for pigs, which is prepared from the following raw materials by a predetermined proportion: astragalus root, haw, malt, rhizoma dioscoreae, grape seeds, purple perilla seed, spine date seed, licorice root, medicated leaven, prepared rhizome of rehmannia, dandelion, matrimony vine, carrot powder, oxyneurine powder, green bean powder, acanthopanax root powder, bitter gourd powder, radish seeds, powder of Chinese scholar tree leaves, clove, cardamom, iodine salt, cane sugar, gourmet powder, Chinese anise, ginger powder, cassia bark, zeolite powder, medical stone powder, sepiolite powder, soya bean waste flour, barley powder and groundnut meal.

The invention discloses Lactobacillus plantarum ZN-3 and application thereof. The Lactobacillus plantarum ZN-3 provided herein is collected in CCTCC (China Center for Type Culture Collection) under CCTCC NO: M 2017286. The Lactobacillus plantarum ZN-3 provided herein features acid tolerance and cholate tolerance, can be implanted to intestines via the stomach to inhibit zoonotic pathogens, including gram-negative bacteria that includes Escherichia coli, salmonella, Pasteurella multocida, Erysipelothrix rhuriopathiae, Haemophilus parasuis and porcine infectious pleuropneumonia, as well as gram-positive bacteria that include Streptococcus suis, Staphylococcus aureus, and Staphylococcus epidermidis. Compared with antibiotics, the Lactobacillus plantarum ZN-3 has good antibacterial effect for pathogenic bacteria having high drug tolerance.

The invention provides a morphinan derivative of the Formula (I): (wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(═O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like) or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.

The invention provides a novel skin anti-allergy and repair composition, and also provides skin repair cream containing the skin anti-allergy and repair composition, and a preparation method of the skin repair cream. An anti-allergy and anti-inflammatory traditional Chinese medicine composition extract aiming at sensitive or damaged skin multi-dermatitis is adopted, meanwhile, other component rawmaterials are supplemented, and after compounding, the skin repair cream has synergetic effects of clearing heat, detoxifying and cooling blood, and can be beneficial to diminishing inflammation, sterilizing, astringing, repairing, improving skin resistance, eliminating scytitis, astringing, moistening, lustring skins, repairing damaged parts, and recovering elasticity and luster of the skins. Theskin repair cream can be used for eliminating carbuncle swell, cleansing, lustring, nourishing and protecting the skins, and is suitable for skin types with skin allergy, pruritus, desquamation, inflammation and the like caused by misusing cosmetics.

The present invention relates to compositions containing unconjugated estrogens and methods of their use in the treatment of conditions associated with hypoestrogenism or reduced estrogen levels in females.

The invention provides a collagen-based dura on the basis of a process-friendly type ion liquid on-site spinning technology, and a preparation method thereof. The preparation method comprises the steps of: dissolving I type collagen by a novel process-friendly solvent system-ion liquid and sodium salt composite system, fully soaking by taking decellularized pig dermis as a substrate through an electrolyte solution, carrying out electrostatic spinning by taking air as a medium, and regulating the pore structure of collagen fibers by adjusting the electrospinning conditions; removing residual ion liquid with a proper eluent, and carrying out freeze-drying, sterilization and packaging to obtain the collagen-based dura. The collagen-based dura has two or more layers of structures: the aperture of collagen fibers at one side close to brain tissue is controlled to be 3mu m and below, and the aperture of collagen fibers at one side far away from brain tissue is controlled to be 20mu m and above. Compared with the traditional solvent spinning, the preparation method is process-friendly, the toxic and side effects are reduced, and the triple-helical structure of the collagen can be furthest retained.

A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure and having the function of diminishing lymphocytes circulating through the periphery; and an immunosuppressant and / or an anti-inflammatory agent.

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

The invention provides a fully human monoclonal antibody against tetanus toxin. The amino acid sequences of a heavy-chain variable region and a light-chain variable region of the monoclonal antibody are SEQ ID No. 3 and SEQ ID No. 4, respectively; preferably, the amino acid sequences of a heavy chain and a light chain of the monoclonal antibody are SEQ ID No. 1 and SEQ ID No. 2, respectively. The invention further provides a preparation method and application of the fully human monoclonal antibody against tetanus toxin and a derivative thereof. The fully human monoclonal antibody against tetanus toxin provided by the invention can eliminate the biological risks of anaphylactic reaction and virus contamination, has a sufficiently long half life and high titer and in-vivo activity, can be applied to large-scale industrial production.

A nutritive cordyceps additive of forage for promoting growth of fowls and animals, and improving the taste of egg and meat is prepared from Paecilomyces Guni, through slant culture, liquid seed culture, liquid fermenting, culturing in solid medium, etc.

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

A Chinese medicine in the form of granules for treating chronic atrophic gastritis and lesion before stomach cancer is prepared from 8 Chinese medicinal materials including astragalus root, white atractylodes rhizome, coix seed, scutellaria root, etc. through pretreating, extracting effective components, concentrating, pulverizing, coating, mixing, granulating and packaging. Its advantages are high curative effect and no toxic by-effect.

The invention discloses a composite traditional Chinese medicine composition which can stimulate the appetite and tonify the spleen, can effectively strengthen the physique of cultured animals and promote the rapid growth of the cultured animals, as well as belongs to the field of veterinary medicines. The composite traditional Chinese medicine composition comprises the ingredients of fructus crataegi cuneatae, pine needle, dried orange peel, garlic, radix astragali and sodium sulfate. The composite traditional Chinese medicine composition can be directly added into feeds of livestock and aquatic products, can promote the rapid growth of the cultured animals, and can also be processed into powdered drug, granules, tablets, pills and the like for treating diseases of poor growth of the livestock and the aquatic products and the rehabilitation of recovered cultured animals. The raw materials of the composite traditional Chinese medicine composition are Chinese medicinal plants, are convenient to obtain, and low in cost. The composite traditional Chinese medicine composition has remarkable treatment effect and medicine effect, little dosage, convenient use and rich means. In addition,the composite traditional Chinese medicine composition is environmental-friendly without containing antibiotics, and has no residue and little toxic and side effects.

The invention discloses a solid beverage containing Radix Puerariae. The solid beverage is prepared by using 50-80 parts by weight of a Radix Puerariae extract, 30-50 parts by weight of dark plum, 5-10 parts by weight of soya lecithin, 5-10 parts by weight of Chinese magnoliavine and 5-10 parts by weight of turmeric. The solid beverage solves the problem of the single efficacy of anti-alcoholic products, is prepared through using the essences of purely natural green plants, and can accelerate the liver metabolism, reduce the liver loss, improve the liver immunity and promote the absorption and decomposition of alcohol.

The invention discloses a traditional Chinese medicine formulation for curing senile dementia and a preparation method thereof. The traditional Chinese medicine formulation is made of ginseng, milk veteh, epimedium, fumitory, rhizoma gastrodiae, angelica, radid polygoni multflori preparata, sealwort and grassleaf sweelflag rhizome which are performed by an ethanol extracting technology and a poach technology. The traditional Chinese medicine formulation is ground by the theory of traditional Chinese medicine and adopts a scientific theory and an advanced technology to develop the traditional Chinese medicine formulation with good curative effect and fewer side effects and being used for curing the senile dementia. The experimental research shows that the traditional Chinese medicine formulation can improve the learning memory ability of an AD rat model. Meanwhile, the traditional Chinese medicine formulation can improve the antifatigue and anti-stress ability of an organism and has good curative effect on the kidney empty. In addition, the invention also provides an optimized preparation method suitable for the industrial production.

The invention relates to an anti-wrinkle compact composition, an emulsion and a preparation method and application thereof. The anti-wrinkle compact composition comprises the following active ingredients: angelica sinensis, panax notoginseng, astragalus membranaceus, saposhnicovia divaricata, gastrodia elata, glossy privet fruits, glycyrrhiza, calendula, albizzia julibrissin, okra, acetyl hexapeptide-8, acetyl octapeptide-3, oligopeptides-3 and dipalmitoyl hydroxyproline. The anti-wrinkle compact composition taking Chinese herbal medicines as main materials and biological small molecular substances as auxiliary materials is safe and free of toxic and side effects. The anti-wrinkle compact composition not only has a strong anti-ageing effect, but also can alleviate various uncomfortable symptoms of skin, improve sensitive skin, smoothen the nutritional channel and the energy channel of the skin and recover elasticity of the skin and improve the brightness of the skin, so that the skin is young, healthy and active. Therefore, the anti-wrinkle compact composition is suitable for preparing skincare products.

The invention provides a chitosan-chitosan derivative nanosphere product for loading an indissoluble medicament. The product has a porous structure with controllable aperture, thus being capable of controlling the medicament to be released relatively quickly and stably. When the nanosphere product is taken as an oral preparation, as a large number of positive charges exist on the surface of the nanosphere product, the adhesiveness and membrane permeability of the preparation on a small intestine part are improved greatly, and the oral bioavailability of the medicament is enhanced. Simultaneously, the product can be jointly loaded with medicaments with electronegativity or coupling targeting ligands to achieve the aim of coordinating administration or targeting administration. The chitosan-chitosan derivative nanosphere product not only can be used for improving the tolerance of a patient, but also has relatively low toxic and side effects. The invention also provides a preparation method of the chitosan-chitosan derivative nanosphere product for loading the indissoluble medicament. The grain size of the product prepared from the method is uniform. The preparation method is applicable to medicaments which are insoluble in water but soluble in fat, and can be used for controlling nanocrystallines of the indissoluble medicament to be uniformly distributed in the nanosphere in an in-situ crystallization way so as to improve the medicament loading efficiency.

The invention discloses a traditional Chinese medicine composition for promoting pig growth and improving pork quality. The composition is prepared from the following components in parts by weight: 15-60 parts of rhizoma dryopteris crassirhizomae, 15-60 parts of polygonum multiflorum, 30-60 parts of malt, 9-30 parts of semen arecae, 60-180 parts of fried soybeans, 15-24 parts of pericarpium citri reticulatae, 9-24 parts of rhizoma atractylodis macrocephalae, 9-24 parts of astragalus membranaceus, 9-24 parts of poria cocos, 9-24 parts of codonopsis pilosula, 6-18 parts of hawthorn, 6-12 parts of rhizoma alismatis, 6-18 parts of glossy privet fruit, 6-9 parts of fructus amomi, 6-9 parts of semen myristicae, 6-9 parts of fennel, 6-9 parts of clove and 9-15 parts of cinnamon. The traditional Chinese medicine composition is obtained by compounding multiple traditional Chinese medicinal components, and has the functions of tonifying middle-jiao and qi, strengthening spleen, inducing diuresis, promoting digestion, regulating qi circulation, appetizing, killing parasite and fattening, and can be used for promoting pig growth, improving feed utilization and improving pork quality. The composition is a pure traditional Chinese medicine preparation, does not have medicine residue, does not have toxic or side effect, is convenient to use, and is safe and reliable.

The present invention relates to a gastrodine powder injection preparation. It is made up by using gastrodine as main component, its content is 30-99.9%, and water soluble medicinal auxiliary or water or their mixture. Said powder injection is good in stability, less in toxic side effect and extensive application range, and possesses the function of sedation, analgesia, hypnotic action, resisting vertigo, resisting convulsion, resisting epilepsy, improving cardio-carebral vascular function and resisting senility, etc.

The present invention discloses an amorphous hydrocolloid dressing containing liposome, and a preparation method thereof. The amorphous hydrocolloid dressing comprises the following raw materials by mass: 10-40% of a liposome solution, 2-10% of polyethylene glycol (PEG) having a molecular weight of more than 1000, 10-35% of propylene glycol, 0.1-2% of polyvinyl alcohol (PVA), 10-35% of glycerol, 15-50% of a high water-absorbing substance, 0.1-2% of an antibacterial agent, 0.1-2% of an antioxidant, and 0.1-2% of an anti-inflammatory and anti-seepage material. According to the present invention, the three-step operation comprising liposome solution modification and hydrocolloid matrix preparation, hydrocolloid water-absorbing base particle dispersion and hydrocolloid dressing forming is performed to prepare the amorphous hydrocolloid dressing; and the amorphous hydrocolloid dressing has characteristics of good effect, rapid effect, no toxic-side effect, active anti-seepage effect, active antibacterial function, and healing promoting.

The invention discloses new application of Japanese climbing fern spore in preparing lead excretion medicines or health products. The Japanese climbing fern spore can be prepared into medicines or health products for people with high lead.

Provided are a pancreas perfusion apparatus capable of administering a drug only to the pancreas and strictly suppressing a leakage of the drug outside the pancreas and a method for controlling the same. The apparatus includes: a first vein occlusion section occluding a vein through which a venous blood from the pancreas flows; a second vein occlusion section occluding a vein into which a venous blood from collateral pathways outside the pancreas flows; an artery occlusion section occluding sites where an artery that nourishes the pancreas is connected to arteries that nourish other tissues; a drug administration section recovering a liquid upstream of the first vein occlusion section and supplying the recovered liquid to the artery; a systemic circulation section recovering a liquid upstream of the second vein occlusion section and feeding the recovered liquid into a systemic circulation; and a control device controlling the systemic circulation pump.

A disclosed soil sterilizing agent is prepared from the following raw materials in parts by weight: 5-10 parts of gleditsia sinensis Lam, 8-12 parts of fructus cnidii, 10-15 part of ulmus macrocarpa Hance, 8-13 part of cortex pseudolaricis, 10-16 part of sulfur, 5-10 part of pumpkin seed, 5-10 part of radix agrimoniae pilodae, and 8-12 part of chaulmoogratree seed. The soil sterilizing agent employs modern science and technology and biological technology, the selected raw materials are scientifically matched, and the agent is a pollution-free wide-spectrum soil special-purpose pesticide which is extracted through supercritical carbon dioxide. Compared with a water decoction process in the prior art, the effective compositions are relatively easily extracted, the traditional Chinese medicine utilization rate is high, the insecticidal effect and the sterilizing effect are relatively good, and the drug property is mild. The agent is capable of effectively killing insects, bacteria and ova in soil without polluting environment, is basically free of toxic and side effect on human and animals, is long in persistent period, low in usage amount and high in safety.

The invention discloses a blue-light luminous capsule capable of being used for killing helicobacter pylori, which comprises a sealed shell. A control circuit board is arranged in the shell and is successively serially connected with a power source, a switch and an LED bulb emitting blue light, at least one portion in the shell is transparent, and accordingly the light emitted from the LED bulb is transmitted outwards. A blue-light bactericidal principle is adopted to realize the purpose of killing the helicobacter pylori of the gastrointestinal tract of a patient. The blue-light luminous capsule has the advantages of small volume, light weight, independent structure and the like, is applicable to realizing blue-light illumination in severe special environments such as gastrointestinal tracts and the like, can be integrally swallowed by the patient in a medicine taking manner, is used for realizing blue-light illumination for the inner wall of the gastrointestinal tract of the patient, kills the helicobacter pylori, is a pollution-free disposable miniature medical instrument, does not cause any wounds on gastrointestinal tissues and other organs of the patient, is fine in sterilization effect and free of poison and side effects, and excellently resolves problems that traditionally orally administrated medicine is poor in helicobacter pylori killing effect and high in side effects.

The invention relates to a release speed-controllable type silk fibroin nanometer microsphere loading methylprednisolone and dexamethasone. The release speed-controllable type silk fibroin nanometer microsphere comprises silk fibroin with lower and higher release speeds; after the silk fibroin with lower and higher release speeds are dissolved, the molecular weight cutoff of the silk fibroin with lower drug release speed after dialysis is 12000 to 14000; the molecular weight cutoff of the silk fibroin with higher drug release speed is 100 to 500; the average particle size of the silk fibroin nanometer microsphere loading methylprednisolone and dexamethasone is 35 to 125nm. The release speed-controllable type silk fibroin nanometer microsphere loading methylprednisolone and dexamethasone has the advantages that the action times of methylprednisolone and dexamethasone at certain dosages can be effectively controlled according to the administration time after injury, the half-life period is controlled, the medicine effect is effectively realized under the condition of joint administration, the therapy effect is improved, and the toxic or side effect and poor reaction during single administration is reduced.