150 results about "Heart muscle extract" patented technology

A system for diagnosing and monitoring myocardial ischemia for automated remote patient care is presented. A database stores monitoring sets containing recorded measures relating to patient information recorded on a substantially continuous basis. A server retrieving and processing the monitoring sets includes a comparison module determining a patient status change by comparing recorded measures and time from each of the monitoring sets to other recorded measures and time from another monitoring set with both recorded measures relating to a same type of patient information recorded at different times, and an analysis module testing each patient status change for, an onset, a progression, a regression, and a status quo of myocardial ischemia against a predetermined indicator threshold, including hysteresis threshold, corresponding to same type of patient information as the compared recorded measures.

Techniques are described for detecting and distinguishing among ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one technique, these conditions are detected and distinguished based on an analysis of: the interval between the QRS complex and the peak of a T-wave (QTmax), the interval between the QRS complex and the end of a T-wave (QTend), alone or in combination with a change in ST segment elevation. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo / hyperglycemia can be properly distinguished from changes caused by cardiac ischemia. In another technique, hyperglycemia and hypoglycemia are predicted, detected and / or distinguished from one another based on an analysis of the amplitudes of P-waves, QRS-complexes and T-waves within the IEGM. Appropriate warning signals are delivered and therapy is automatically adjusted.

Techniques are described for detecting and distinguishing among ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one technique, these conditions are detected and distinguished based on an analysis of: the interval between the QRS complex and the peak of a T-wave (QTmax), the interval between the QRS complex and the end of a T-wave (QTend), alone or in combination with a change in ST segment elevation. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo / hyperglycemia can be properly distinguished from changes caused by cardiac ischemia. In another technique, hyperglycemia and hypoglycemia are predicted, detected and / or distinguished from one another based on an analysis of the amplitudes of P-waves, QRS-complexes and T-waves within the IEGM. Appropriate warning signals are delivered and therapy is automatically adjusted.

An apparatus and method for creating drug-filled pockets within muscle tissue, such as myocardium of the heart for increasing angiogenesis. More particularly, the apparatus has an excising assembly with a dilator tip for penetrating and advancing through the surface and body of a muscle or organ, such as the heart. Preferably, the dilator tip has a low level laser optical fiber emission to ease the passage of the excising assembly and provide thermal damage which also stimulates angiogenesis. More preferably, the dilator tip also disperses a pharmacologically active substance as the apparatus is passed through the tissue and / or creates pockets. The excising assembly is connected to a hand-held control device from which the operator pushes a switch to activate a punching mechanism within the excising assembly. The punching mechanism cuts a discrete piece of muscle tissue and traps it within the excising assembly leaving a pocket in the remaining muscle tissue. The excising assembly may also optionally release a bolus of the pharmacologically active substance into the pocket so created. Most preferably, there is a timing mechanism to measure the contraction of the heart, and the timing mechanism is synchronized with the operator's switch on the hand-held device to ensure that the punching occurs at maximum contraction of systole. A measurement guide determines how much excised tissue is trapped in the reservoir of the excising assembly. At a threshold level of filling, the surgeon will remove the excising assembly from the hand-held control device and open the punching mechanism for release of tissue. More preferably, the threshold level of filling will automatically turn off the switch to the punching mechanism to indicate to the surgeon the need to empty the excising assembly of tissue.

An X-ray CT apparatus 1 comprises a blood-flow information acquisition unit, a correction value calculating unit and a blood-flow image generating unit 24 e. The blood-flow information acquisition unit obtains information of a relative blood flow rate in the myocardium of the subject P based on the CT image. The correction value calculating unit obtains a correction value based on the CT image in a concentration transition period defined to be a period from immediately after starting of a continuously injection of a contrast medium into the subject P until the contrast medium injected reaches to the myocardium, increases, and will be in a state where it can be considered that the contrast medium is saturated in a constant value. The blood-flow image generating unit 24 e generating a blood flow value image in the myocardium by correcting the information of the relative blood flow rate with the correction value.

A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as left bundle branch block beats and normal sinus beats. The processor applies different ischemia tests to the two different beat types, and generates alert when it detects ischemia.

A Chinese medicine for treating hypertension, hyperlipemia and hyperglycemia is prepared from 22 Chinese-medicinal materials including chrysanthemum flower, astragalus root, red sage root, haw, etc.

The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.

A heart function analysis apparatus adapted to analyze a motion of a heart by using time-series image data representing an image of the heart. The heart function analysis apparatus includes a strain-value acquisition unit configured to acquire time-series strain values in thickness of a heart muscle from the time-series image data, a normalized strain value calculation unit configured to normalize the time-series strain values, and an output unit configured to output the time-series normalized strain values.

A system and method for providing a dark-blood technique for contrast-enhanced cardiac magnetic resonance, improving visualization of subendocardial infarcts or perfusion abnormalities that may otherwise be difficult to distinguish from the bright blood pool. In one technique the dark-blood preparation is performed using a driven-equilibrium fourier transform (DEFT) preparation with motion sensitizing gradients which attenuate the signal in the ventricular cavities related to incoherent phase losses resulting from non-steady flow within the heart. This dark-blood preparation preserves the underlying contrast characteristics of the pulse sequence causing a myocardial infarction to be bright while rendering the blood pool dark. When applied to perfusion imaging, this dark-blood preparation will help eliminate artifacts resulting from the juxtaposition of a bright ventricular cavity and relatively dark myocardium.

An apparatus includes a transformation table acquiring unit, a blood-flow information acquisition unit and a blood-flow image generating unit. The transformation table acquiring unit obtains a transformation table for transforming unspecified information representing a concentration of a contrast medium in a myocardium into an unspecified blood flow value image based on a CT image acquired in a concentration transition period. The blood-flow information acquisition unit obtains information representing the concentration of the contrast medium based on a CT image acquired during a constant concentration period. The blood-flow image generating unit generates a blood flow value image based on the information representing the concentration of the contrast medium according to the transformation table.

The invention discloses an extract of agrimony total flavonoids and an extraction and preparation method thereof; the total amount of ketosteroid compounds accounts for 25 percent to 100 percent of the total extraction matter. The invention takes agrimony as raw material and organic solvent whether containing or not containing water as extraction solvent. The extraction procedure is as following: extracting, leaching with solvent and adsorbing resin column to make purification process or using inorganic acid to regulate the PH value of concentrated solution to be no higher than 3, and then obtaining the extraction matter of agrimony after processing. Experiments prove that the extraction matter of agrimony total flavonoids has functions of antioxidation, anti-myocardial ischemia and reducing blood lipid. The extraction matter of agrimony total flavonoids can be used as food preservative and health product additive; the extraction matter of agrimony total flavonoids, carriers acceptable in pharmacy or excipient are made into various pharmaceutical dosage forms for anti-myocardial ischemia and reducing blood lipid. The invention has the advantages of simple technics and good treatment effect and can be widely used for curing or preventing coronary heart disease, hyperlipoidemia, high blood pressure or preventing cardio-cerebrovascular diseases such as atherosclerosis, etc.

The invention discloses a medicine combination of snakegourd peel extract and allium macrostemon extract. The medicine combination is composed of 50-90 parts of snakegourd peel extract and 10-50 parts of allium macrostemon extract by weight; wherein, the total amino acid content in the snakegourd peel extract is not less than 50 percent, if calculated according to arginine, and the total saponin content in the allium macrostemon extract is not less than 50 percent, if calculated according to dioscin. The combination has stable quality, and high content of effective ingredients; the technique of the preparation method of the invention is stable, and has good reproduction quality. Proved by pharmacological tests, the combination has better protective effect on acute myocardial ischemia caused by rat hypophysin and canine myocardial ischemia due to coronary artery ligation. The medicine combination of the invention has promising application prospect in the respect of treating cardiovascular system diseases.

A method and system for predicting the onset of heart arrhythmias more accurately observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and the baseline measurement is subtracted from the second set of ECG signals on a beat-to-beat basis. Afterwards, a residuum signal is generated for each lead based on the subtraction. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals.

The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatogical conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

The invention discloses Niugu health dried noodles. The Niugu health dried noodles comprise 100-110 parts of wheat flour, 20-30 parts of oat flour, 10-15 parts of ground peanut flour, 2-4 parts of rehmannia leaf, 3-4 parts of root of Kirilow Rhodiola, 13-20 parts of ox bone, 2-3 parts of glossy privet fruit, 2-3 parts of turmeric, 3-4 parts of garlic, 2-3 parts of peach leaf, 2-3 parts of boxthorn leaf, 1-2 parts of Chinese hawthorn seed, 2-4 parts of pomelo peel, 2-3 parts of lotus leaf, 1-2 parts of lingzhi mushroom, salt, and the proper amount of water. The Niugu health dried noodles are smooth to taste and can be eaten without causing burning up and damp increase to human body. The Niugu health dried noodles contain nutrients, and resources are saved and production cost is lowered by adding the ox bone. A making method of the Niugu health dried noodles is slightly destructive to nutrients in the ox bone, and the nutrients of the ox bone are fully retained in the product and protect human cell tissue. The root of Kirilow Rhodiola is anti-aging, anti-hypoxic, anti-fatigue, radiation-proof, anti-tumor and anti-viral, enhances brain function, and improves myocardial function.

An intervention type aorta blood pump for ischemic heart diseases and an installation method thereof belong to the technical field of bioengineering. The intervention type aorta blood pump is composed of an aorta blood pump (2) and an aorta blood pump outer support (1), wherein the aorta blood pump (2) is in a cylinder shape and can penetrate through the aorta blood pump outer support (1). When the intervention type aorta blood pump is installed, thoracic surgery is avoided, the intervention type aorta blood pump can be pushed between an aortic root and an arcus aortae from the far end through a cathode, the intervention type aorta blood pump can be fixed in an aorta vessel though vessel outer ligation technology, and the intervention type aorta blood pump can be transplanted matched with coronary artery bypass grafting. The intervention type aorta blood pump can obviously improve coronary artery infusion amount and myocardium blood supply conditions.

A caffeoylquinic acid-rich extract obtained from Erigeron multiradiatus and a method for producing the same. A caffeoylquinic acid-rich extract includes at least 15% by weight of a mixture of certain caffeoylquinic acids. The extract with the mixture of caffeoylquinic acids is highly efficacious in treating and preventing myocardial ischemia or myocardial ischemia reperfusion injuries. A method for treating or preventing a disease caused by myocardial ischemia or myocardial ischemia reperfusion includes administering a therapeutically effective amount of the caffeoylquinic acid-rich extract to a subject. Pharmaceutical compositions including the caffeoylquinic acid-rich extract are also disclosed.

The invention discloses a miocardial infarction automatic detection method based on multimodality fused neural network. The method comprises the steps of (1) cutting off single heart beat, and generating 12 linked electrocardiosignal samples; (2) building a convolution neural network model of the 12 linked electrocardiosignal; (3) training parameters of the convolution neural network; and (4) automatically identifying the tested samples, inputting the divided test samples into the convolution neural network, performing operating to obtain a two-dimensional predicted value vector correspondingto the test samples, performing outputting, generating two-dimensional label vectors for the label of the test samples by a one-hot coding method, comparing the output predicted value with the label of the test samples to inspect whether classification is right or not, and identifying the performance of the model through the classification result y_pred. The method can obtain high accuracy rate for multiple linking electrocardiosignal, wherein the distinguishing accuracy rate of miocardial infarction heart beat can achieve 99.51%.

Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

The present invention discloses a medicine composition containing rhodiola root extract and ginkgo leaf extract for curing angiocardiopathy and cerebrovascular diseases of cerebral apoplexy, coronary heart disease and angina pectoris, etc. Said medicine composition can be made into oral tablet, capsule, granules and injection preparation.

The invention relates to a method for extracting Yulang block to obtain Yulang water extractive, alcohol extractive, polysaccharide and chromocor. Researches have proved that the Yulang water extractive, alcohol extractive, polysaccharide and chromocor can stably reduce hypertension, restrain heart muscle retraction, reduce heart muscle oxygen consumption, improve coronary flux and reduce myocardial ischemia refill hurt, while it can release breath, release the asthma caused by acetylcholine simulation, and resist the retraction of acetylcholine or ergamine on bronchi. And the Yulang water extractive and polysaccharide can resist senile dementia and hepatitis or the like. The invention supplies a novel Chinese drug for treating hypertension, coronary disease, or the like, without side effect.

The present invention relates to a gastrodine powder injection preparation. It is made up by using gastrodine as main component, its content is 30-99.9%, and water soluble medicinal auxiliary or water or their mixture. Said powder injection is good in stability, less in toxic side effect and extensive application range, and possesses the function of sedation, analgesia, hypnotic action, resisting vertigo, resisting convulsion, resisting epilepsy, improving cardio-carebral vascular function and resisting senility, etc.

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

The invention relates to a dynamic monitoring system and a warning method for a myocardial blood oxygen supply and demand state based on heart rate and pulses. The dynamic monitoring system is characterized by comprising a signal acquisition unit and a display terminal, wherein the signal acquisition unit comprises an initial blood pressure setting module, a signal acquisition module and a communication module, and the signal acquisition module is used for acquiring heart rate signals via a heart rate sensor, acquiring radial artery pulse signals via a pulse pressure sensor and sending acquired signals to the display terminal; the display terminal comprises a data transmission unit, a pulse signal processing unit, an exercise intensity detecting unit and a warning unit and is used for calculating subendocardial myocardial viability by means of analyzing the radial artery pulse signals in real time and assessing the myocardial blood oxygen supply and demand state according to the current exercise intensity of a user. The invention further provides the warning method of the dynamic monitoring system. The dynamic monitoring system and the warning method have the advantages that corresponding prompts and warnings can be provided for the user according to measurement results of the subendocardial myocardial viability rate, and dynamic monitoring on myocardial blood oxygen supply and demand state of a human body can be achieved.

A late potential detecting system has an implantable medical device connected to at least one cardiac lead having implantable electrodes positioned at different sites of a ventricle myocardium. A sampling unit of the implantable medical device records electrogram samples for the different implantable electrodes to get different sample sets. The electrogram samples of the sample sets are time synchronized and magnitude potential representations of the potential data of the electrogram samples are determined. The magnitude potential representations of the time synchronized electrogram samples are then co-processed and used for determining a parameter that is indicative of any late potentials of the monitored ventricle.

Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electro-mechanical stability, and responding to the same. One or more signal indicative of electrical functioning of a patient's heart is obtained, as is one or more signal indicative of mechanical functioning of the patient's heart. The patient's myocardial electrical stability is monitored based on the one or more signal indicative of electrical functioning of the patient's heart, and the patient's myocardial mechanical stability is monitored based on the one or more signal indicative of mechanical functioning of the patient's heart. Based on both the myocardial electrical stability and myocardial mechanical stability, the patient's risk of an adverse cardiac event is monitored. Further, when the patient is at risk of an adverse cardiac event, a response is triggered that is specific to both the myocardial electrical stability and the myocardial mechanical stability. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

The invention discloses a health food with an anti-tumor effect and a preparation process of the health food. The health food is prepared from the following components in percentage by weight: 10-65 percent of grifola frondosa polysaccharide, 10-50 percent of coriolus versicolor polysaccharide, 5-40 percent of lentinan, 10-30 percent of ganoderma applanatum polysaccharide and 5-10 percent of coprinus comatus polysaccharide. The health food is prepared by culturing, filtering, purifying, drying, grinding, compounding and filling, has a remarkable anti-tumor effect, also has the effects of improving immunity, protecting liver, resisting radiation and ulcer, protecting heart, resisting myocardial ischemia, resisting mutation, resisting oxidation, resisting fatigue and senescence, improving memory and the like, and is suitable for people with cancers, chronic hepatitis B, phthisis, trachitis, neurasthenia and the like.