418 results about "Blood supply" patented technology

The invention is a delivery catheter, e.g., a guide catheter, having an imaging element in proximity to the distal end of the catheter. Catheters of the invention are able to placement of the catheter in proximity to an ostium, thereby increasing the efficiency of contrast delivery while reducing the risk of ischemia due to blocked blood supply. The invention additionally assists in maintaining catheter position during delivery of a fluid from the catheter, resulting in better performance with less fluid. For example, a catheter of the invention can be used to produce improved fluoroscopic images with less overall contrast. This improvement reduces the risk of an allergic reaction to the contrast while decreasing the length of time for a procedure, i.e., because of a need to re-contrast.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

Systems and methods are disclosed for diagnosis, risk assessment, and / or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel.

The invention relates to the technical field of intelligent medical systems, and discloses a cerebral apoplexy onset risk assessment and reminding method and system.The method comprises the steps that continuous medical structured detection data are collected, and the data comprise carotid artery blood flow parameters, brain oxygen saturation, heart rate variability and metabolic indexes; inputting a bidirectional LSTM, a differential convolutional network, a wavelet residual network and a multi-layer perceptron to extract nonlinear features; constructing a neural function coupling structure diagram of four nodes of cerebral blood supply, oxygen supply, autonomous regulation and metabolic steady state; calculating inter-node time sequence offset correlation and a stable factor to obtain a coupling anomaly coefficient; and driving the embedded network by using a graph structure and a node feature input mechanism, and outputting a risk state assessment result. According to the method, the neural function coupling structure diagram is constructed and the mechanism is introduced to drive the embedded network, so that high-precision identification of the multi-system collaborative abnormal state and dynamic evaluation of the stroke risk level are realized.

The invention provides a balloon dilatation catheter, and belongs to the technical field of balloon dilatation catheters. The balloon dilatation catheter comprises a catheter body, the far end of the catheter body is provided with a balloon body used for dilating a narrow part, and the near end of the catheter body is provided with an operating handle used for charging and discharging a filling medium into the balloon body. A flow channel allowing blood to penetrate through is formed in the balloon body and / or between the balloon body and the outer side wall of the catheter body in the axial extending direction of the catheter body, in the working process, after the balloon body is filled, a narrow part is treated, and the blood in the narrow part penetrates through the flow channel to continue to be circulated. The balloon is mainly used for solving the technical problems that in the prior art, when a balloon dilates, blood flow is blocked, consequently, far-end blood supply is insufficient, and the drug transfer effect is affected due to insufficient contact time of the balloon and the blood vessel wall.

The invention provides a clinical diagnosis and treatment path generation method and system for tracking a chest pain patient. Wherein a dynamic spatio-temporal data atlas is constructed by synchronously collecting respiratory rhythm phase difference, coronary artery calcification integral and hypersensitive troponin curve slope, and risk degree transition signals are generated by coupling analysis of ST segment elevation amplitude asymmetric growth, left ventricular ejection fraction attenuation gradient and B-type natriuretic peptide release rate. In the acute stage, the constraint relation between a vascular recanalization time window and thrombolysis taboo is dynamically bound, in the subacute stage, a phase synchronization rule for enhancing CT scanning and anticoagulant drug dosage is established through a multidisciplinary interface, intravascular ultrasonic plaque morphological mutation characteristics and extracorporeal circulation parameters are fused, the blood supply reconstruction time sequence is dynamically adjusted based on a myocardial oxygen consumption balance equation, and the thrombolysis time sequence is determined. And path self-optimization is realized through space-time superposition of an interventional therapy delay parameter and a drug metabolism curve. According to the technical scheme provided by the invention, chest pain diagnosis and treatment path dynamic optimization and multi-modal parameter collaborative decision-making are realized, and the risk layering precision and the treatment timeliness are improved.

The invention discloses a brain health monitoring and cerebral infarction early warning method and system for old people. The method comprises the steps that electroencephalogram, electrocardio, blood oxygen and cerebral blood flow velocity multi-mode physiological signal data are collected; adopting a characteristic mode decomposition method to decompose the multi-mode physiological signal data; the method comprises the following steps: introducing a KAN network into an MATE structure, carrying out nonlinear mapping and feature reconstruction, and constructing a KAMATE model; an improved Bayesian optimization algorithm is obtained based on the Bayesian optimization algorithm in combination with a dynamic balance strategy; the improved Bayesian optimization algorithm is combined with the characteristic mode decomposition method to achieve characteristic decomposition of the multi-mode physiological signals, and parameters of the KAMATE model are optimized; dividing the brain health state into four grades according to a prediction result output by the KAMATE model; according to the invention, real-time early warning of abnormal cerebral blood supply, cognitive decline and cerebral infarction high-risk states of the elderly can be realized, intelligent support is provided for health management of the elderly, and the method has important application value.

The invention discloses a blood component separation system and a control method, and belongs to the field of blood separation.The system comprises a centrifugal device, a blood supply pipeline, an air detector valve and a blood pump, a liquid outlet of the centrifugal device is connected with a separation pipeline, and the separation pipeline is sequentially connected with a first plasma bag and a second plasma bag; a centrifugal pressure sensor, a centrifugal high-speed camera and a red blood cell sensor; and the control center comprises a data acquisition module, a data analysis module and a centrifugal control module. The control method comprises steps S1 to S4. Dynamic intelligent regulation and control and automatic control of the blood component centrifugal separation system are achieved, the centrifugal effect is optimized through the image recognition technology, the image recognition technology is superior to the photoelectric recognition technology in the prior art, excessive centrifugation is avoided, meanwhile, the centrifugal quality is guaranteed, and the quality and activity of separated blood components are effectively guaranteed.

The invention discloses a method for controlling the compaction degree of a left heart and a right heart in an extracorporeal circulation operation, which comprises the following steps of: in an in-vitro environment, mounting a peristaltic pump at a left heart inlet and a right heart inlet of an extracorporeal circulation device; a liquid inlet of the peristaltic pump is connected with a liquid inlet pump, and a liquid outlet of the peristaltic pump is connected with a liquid outlet pump; and finally, a first pressure measuring structure and a second pressure measuring structure are arranged on the sides, away from the peristaltic pump, of the liquid inlet pump and the liquid outlet pump correspondingly, and the pressure of the liquid inlet pump and the pressure of the liquid outlet pump are adjusted to be-20 mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so that the purpose of quantifying the adjusting mode is achieved, and the adjusting mode is accurate, rapid and high in reliability; the peristaltic pump can effectively avoid the occurrence of risks such as blood component damage, hemolysis, gas embolism and the like caused by reduction of the amount of blood conveyed by the pump, insufficient blood supply or direct interruption of blood circulation due to the condition that a pipe body connected with the peristaltic pump is shrunken or cannot be sucked during an operation.

The invention discloses application of MUC12 gene in preparation of drugs for reducing rectal cancer liver metastasis, and belongs to the technical field of medical biology. According to the invention, the clear relation between colorectal cancer liver metastasis and fructose metabolism reprogramming is revealed from a molecular mechanism for the first time. The invention provides a brand-new therapeutic target and strategy by determining the brand-new transfer promoting factor MUC12 and the mediated fructose metabolism regulation effect thereof. Different from the traditional therapy only aiming at the strategies of tumor cell proliferation, blood supply and the like, the method disclosed by the invention intervenes aiming at a tumor nutrition metabolic pathway, and can weaken the metabolic adaptation and proliferation capacity of metastatic tumor cells in the liver more specifically. Experimental results show that the functions of targeted inhibition of MUC12 or downstream fructose metabolism key enzymes KHK and ALDOB thereof can significantly reduce the invasion and metastasis ability of tumor cells, and at the same time, normal growth of primary tumors cannot be significantly affected.

The invention belongs to the field of biological medicines, and discloses an application of Akkermansia muciniphila or an extracellular vesicle of the Akkermansia muciniphila in preparation of a medicine for alleviating the ischemic necrosis of the alcoholic femoral head. Based on the pathogenesis characteristics of the AIONFH, the Akk bacteria and the extracellular vesicles thereof are used for treating the AIONFH for the first time, the molecular mechanism of the Akk bacteria and the extracellular vesicles thereof for regulating and controlling the intestinal tract-skeleton axis function, inhibiting bone cell apoptosis and improving the bone trabecula microstructure is deeply researched, the anti-pressure ability of bone tissue is improved, and the research blank in the field is filled. Compared with a traditional treatment method, the osteonecrosis pathological change is improved through a single way, and a novel multi-target treatment strategy is provided from multiple aspects of regulating inflammatory response, recovering bone metabolism balance, promoting intraosseous blood supply and the like.

The invention relates to the technical field of medical instruments, in particular to a tissue tray assembly used in an abdominal surgery, which comprises a tray and a traction device, and is characterized in that the tray comprises a tray body and a plurality of support pieces, and the plurality of support pieces are of a scattered structure distributed on the tray body; the supporting pieces are divided into first supporting pieces and second supporting pieces, and the first supporting pieces and the second supporting pieces are distributed in a staggered mode. The supporting piece comprises a sleeve body and a telescopic rod, the telescopic rod is connected with an air pipe, and the amount of air in the telescopic rod is changed by injecting air into or exhausting air from the air pipe, so that the telescopic rod is extended or shortened; the telescopic rod corresponding to the first supporting piece and the telescopic rod corresponding to the second supporting piece are independent in motion form. According to the tissue tray assembly used in the abdominal cavity operation, the situation that tissue in the abdominal cavity is pressed for a long time can be avoided, the situation that blood vessels in the tissue are pressed for a long time is avoided, and the situation that the supported part on the tissue is insufficient in blood supply or ischemia or hypoxia occurs is avoided.

The invention relates to the technical field of medical instruments, and provides a steep pulse-based ablation system and method for liver cancer cells, and the system comprises a tumor feature recognition module which is used for obtaining imaging images of the liver cancer cells and recognizing tumor features, blood supply conditions and tumor centers of the liver cancer cells; the electrode inlet setting module is used for setting a safety boundary of liver cancer cells and setting an ablation area and a focus skin surface of the liver cancer cells based on the safety boundary and tumor characteristics; the ablation effect analysis module is used for calculating the electrode depth and the electrode angle of the liver cancer cells and analyzing the coverage effect of an ablation area; the electric field intensity identification module is used for analyzing cell membrane characteristics of the hepatoma cells, identifying the electroporation effect of the hepatoma cells and identifying the electric field intensity of the hepatoma cells; and the steep pulse ablation module is used for performing ablation treatment on the liver cancer cells in combination with the electric field intensity and a pulse generator to obtain an ablation result. The invention aims to avoid heat injury of surrounding tissues and improve the ablation effect of liver cancer cells.

A patella fracture fixation system includes a peripheral rim bone plate that is configured to be implanted along a parapatellar lateral approach. The bone plate can configured to minimize disruption of blood supply to the patella. The bone plate can be augmented with a Krackow suture pattern to assist in stabilization of a comminuted inferior pole.

The invention provides application of active decapeptide in preparation of a medicine for preventing or treating cerebral apoplexy, and belongs to the technical field of biological medicine, the active decapeptide with the amino acid sequence as shown in SEQ ID NO.1 is applied to prevention or treatment of cerebral apoplexy for the first time, the active decapeptide can effectively inhibit formation of cerebral thrombosis of zebra fish with ischemic cerebral apoplexy, and the active decapeptide can be used for preventing or treating cerebral apoplexy. The brain blood flow supply is recovered; meanwhile, the active decapeptide can significantly reduce the hemorrhagic area and hemorrhagic rate of the zebra fish brain with hemorrhagic stroke, repair brain vascular injury and inhibit the occurrence and development of hemorrhagic stroke. In addition, the active decapeptide has small toxic and side effects, and is of great significance for improving the clinical curative effect of cerebral apoplexy and reducing the medication risk when being used for research and development of novel drugs for resisting cerebral apoplexy.

The invention relates to the technical field of medical image processing, in particular to a pulmonary blood vessel perfusion analysis method based on drainage basin dynamics, which comprises the following steps: acquiring a pulmonary artery blood vessel tree and a pulmonary artery CT film; extracting the pulmonary artery blood vessel tree based on the pulmonary artery blood vessel tree and the pulmonary artery CT film; based on the pulmonary artery blood vessel tree, pressure gradient fields in the pulmonary artery blood vessel tree and on the wall of the pulmonary artery blood vessel tree are calculated; extracting a pulmonary vein basin based on the pressure gradient field; based on the pulmonary vein drainage basin, perfusion analysis is achieved in combination with dynamic hemodynamic simulation; on the basis of perfusion analysis results, lung tissue blood supply conditions are evaluated, a multi-stage connected domain detection method is adopted, the method can more accurately extract a complex pulmonary artery blood vessel tree structure, the actual distribution condition of blood flow can be more truly reflected on the basis of a pressure gradient field drainage basin division method, and dynamic blood flow simulation is introduced, so that the dynamic blood flow simulation effect is improved. By means of the method, perfusion changes in the breathing process can be comprehensively captured, and more comprehensive diagnosis information is provided.

The utility model relates to an intravascular stent, a stent system and a windowing area adjusting method, a stent body section is provided with a stent body inner cavity with two through ends, a branch window penetrating through the stent body inner cavity is formed in the side wall of the stent body section, and the branch window is located on the side wall of the first end of the stent body section and formed to the end side of the first end of the stent body section; the pipe body section is provided with a pipe body inner cavity with two through ends, and one end part of the pipe body section is connected with the second end part of the frame body section, so that the pipe body inner cavity is communicated with the frame body inner cavity. The branch windows of the two intravascular stents can be spliced into a complete closed window, and the overlapped length of the two intravascular stents can be adjusted to adapt to the actual sizes of the three branches on the arch to construct a windowing area with a proper size, so that the blood supply of the three branches on the arch is ensured. When the stent is used for interventional operation, in-vitro windowing or in-situ windowing is not needed, and when the stent is used for open operation, the number of anastomotic stomas can be reduced, the circulation stopping time can be shortened, and meanwhile the three-branch anatomical structure on the arch can be reserved. Therefore, the existing operation requirements are met.

The invention discloses an application of nitro fatty acid in preparation of a product for predicting, preventing and improving adverse cardiovascular events of patients with acute coronary syndrome. The invention provides application of nitro fatty acid in preparation of products for preventing and improving adverse cardiovascular events of ACS patients. According to the application, for the ACS patient, when the concentration of the 12-nitro conjugated linoleic acid in the body is larger than 0.196 ng / ml and the concentration of the 9-nitro conjugated linoleic acid is larger than 0.296 ng / ml, it is judged that the risk that the ACS patient is re-hospitalized and dead due to non-fatal myocardial infarction / unstable angina pectoris / blood supply reconstruction is low. By detecting the content of nitro fatty acid in a biological sample and supplementing nitro fatty acid, the occurrence rate of adverse events can be greatly reduced. Meanwhile, the invention further provides a detection method of nitro fatty acid, and the accuracy of biological sample detection is improved.

The invention relates to a blood protein peptide for promoting hair follicle reconstruction and application thereof, and belongs to the technical field of bioactive peptides. The blood protein peptide disclosed by the invention is selected from one or more of an MLL peptide fragment and a WDL peptide fragment; the amino acid sequence of the MLL peptide fragment is as follows: methionine-leucine-leucine; the amino acid sequence of the WDL peptide fragment is as follows: tryptophan-aspartic acid-leucine. The invention also provides a preparation method of the blood protein peptide and application of the blood protein peptide in hair follicle reconstruction. The blood protein peptide prepared by the technical scheme of the invention can obviously improve local blood supply around hair follicles, and has a wide application prospect in the field of treatment of alopecia.

The invention discloses an enhanced Swinin-Unet liver tumor segmentation method fusing blood vessel guidance and adaptive deformation attention. Through combination of elastic B-spline registration and affine transformation, nonlinear deformation is compensated, a multi-modal image space alignment error is reduced, and tumor boundary blur and feature dislocation are reduced. Topological features are extracted in combination with a blood vessel reconstruction module, and model attention is effectively guided. The encoder adopts a convolution pool and a deformable attention SADR down-sampling, and a lightweight deformable attention module is integrated through jump connection, so that effective multi-scale feature fusion and space alignment are realized, and the model perceptibility is enhanced. The graph theory model is embedded into liver lobe partition and blood vessel curvature constraint, and it is ensured that the segmentation result is strictly matched with blood vessel blood supply topology. In order to solve the class imbalance problem, an FA loss function is provided and combined with a structure correction algorithm (SGDR), so that incomplete segmentation and false positive artifacts are effectively reduced. Experimental verification on a LiTS data set shows that the method is superior to an existing method in liver and tumor segmentation, and Dice coefficients reach 93.38% and 91.39% respectively.

The embodiment of the invention discloses an acute ischemic stroke collateral circulation noninvasive assessment method and device. The method comprises the steps of obtaining a CTP data set and a DSA data set of different collateral circulation levels, constructing an image segmentation model based on a space-modal attention network and an intracranial artery blood supply partition model based on an atlas, subdividing and extracting different areas of the ischemic side from the angles of perfusion function and vascular structure, and taking a DSA score as a gold standard, combining perfusion function quantitative information and vascular structure quantitative information in each region after ischemic side subdivision to construct a collateral circulation scoring model; and taking perfusion function quantitative information and vascular structure quantitative information of each artery blood supply region, the lateral split region, the infarction core region and the penumbra on the ischemic side as input and model training, and predicting to obtain an individual collateral circulation scoring result. According to the method, the non-invasive evaluation accuracy of collateral circulation can be improved by jointly analyzing the perfusion function and the blood vessel structure information provided by the CTP.

The invention relates to the technical field of medical signal processing, in particular to a brain oxygen entropy-based dynamic blood flow simulation system which comprises a data acquisition module, a structure modeling module, a state monitoring module, a simulation calculation module and an anomaly prediction module. According to the method, through synchronous utilization of brain oxygen saturation and blood flow velocity signals, accurate capture of brain oxygen supply and blood flow dynamic dynamic correlation is achieved, sensitivity of abnormal fluctuation recognition is enhanced, individualization and accuracy of blood flow simulation are improved by combining a brain blood vessel geometric structure and blood vessel elasticity and compliance parameters, and multi-point dynamic coupling is utilized to achieve the purpose of improving the accuracy of blood flow simulation. According to the method, abnormal blood supply state recognition is enhanced, brain blood supply stability evaluation is optimized, the local blood flow micro-dynamic feature reduction degree is improved through dynamic updating of the inertia coefficient and the shear stress, the oxygen entropy fluctuation, the shear stress and the flow velocity gradient are combined, the nonlinear coupling relation is extracted, the abnormal event prediction accuracy is improved, and the brain blood supply stability is improved. And the early warning capability of abnormal cerebral blood supply is enhanced.

The invention provides a cannula capable of effectively and smoothly conveying blood from the ascending aorta while reducing the diameter of the cannula. And the front end part of the cannula is retained in the ascending aorta and is used for smoothly conveying blood supplied by the in-vitro artificial membrane lung from the ascending aorta. The cannula comprises a forward blood backflow part (2) and a blood delivery tube (4), wherein the forward blood backflow part (2) is arranged at the front end of the blood delivery tube (4). A guide wire tube (5) which longitudinally extends from a base end part to a front end part is arranged at a near-center position of the axial length in the smooth blood feeding sleeve (1). The blood delivery tube (4) is a catheter arranged on the base end side and used for being connected with the in-vitro artificial membrane lung. The forward blood return unit (2) reverses blood from a reverse direction to a forward direction and guides the blood to the base end side, and is provided with a first blood return tube (6) provided on the base end side and a second blood return tube (7) provided on the tip side. The second blood return tube (7) has side holes (7a, 7b), and a part of an approximately hemispherical bag body (8) is adhered to the inner portion of the tip of the second blood return tube (7).

The invention is suitable for the field of medical technology, and provides a cerebral apoplexy monitoring method and system based on a multi-modal brain-computer interface, and the system comprises a multi-modal physiological data acquisition module, a data denoising and feature extraction module, a multi-modal data fusion module, an abnormal mode recognition module, and a risk signal alarm module. The system can be combined with different types of physiological signals to provide a comprehensive and real-time monitoring platform so as to support early recognition and timely intervention of cerebral apoplexy. The system can effectively capture the electrical activity and blood flow change of the brain of a patient by monitoring electroencephalogram and near infrared spectrum data in real time, so that deep physiological state analysis is provided for doctors; by simultaneously acquiring the electroencephalogram signal and the blood flow change data, the system not only can analyze the neural activity of the brain, but also can evaluate the blood supply condition of the brain. By means of the comprehensive monitoring, a doctor can judge the health condition of the patient more accurately on the basis of comprehensively considering the brain function and the blood flow state.

The invention relates to the field of medical instruments, in particular to a self-adaptive inflatable medical protection restraint system and a monitoring control method. The system comprises a restraint strap body, a pneumatic control module, a biological feedback module and a system control module. An air bag array consisting of a plurality of independent air chambers is arranged in the restraint strap body; the pneumatic control module is used for inflating and deflating each air chamber; the biological feedback module is integrated on the belt body, comprises a pressure sensing unit and a blood supply sensing unit, and is used for monitoring and constraining interface pressure and limb blood supply state in real time; and the system control module receives the monitoring data, generates an instruction based on a preset safety parameter, and drives the pneumatic control module to perform self-adaptive pressure adjustment on the specified air chamber. According to the system, through dynamic monitoring and accurate adjustment, the problem that a traditional restraining device is prone to causing compression injury and blood supply disorder is effectively solved, and safety and comfort are remarkably improved.

The invention relates to a tissue engineering trachea, which combines an additive manufacturing technology with a biological material, simulates the form and the function of a natural gas pipe, designs a cartilage-fiber alternating ring structure and a bionic fiber band structure, and designs a unique blood supply channel in a fiber section. The trachea fiber section is composed of hydrogel with a hierarchical porous structure, and a circumferential blood vessel channel and a radial blood vessel pore channel are designed in the hydrogel so as to promote ingrowth and growth of new blood vessels and optimize the blood supply reconstruction process. The tracheal cartilage section is made into a C-shaped cartilage ring with cartilage cells through a biological printing technology, and necessary mechanical support is provided. The fiber segment and the cartilage segment are effectively integrated through chemical bonds of functional groups to ensure stable connection of the two. Partitioned construction of fibers and cartilage is achieved through the biological 3D printing technology, the bionic tissue engineering trachea is formed in a modular construction-integrated assembly mode, it is verified that repairing and reconstruction of multiple types of tissue bionic tracheas can be achieved, and an innovative solution is provided for tracheal injuries.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

The invention relates to the field of medical apparatus and instruments in rectum surgery, and particularly provides a novel multifunctional intestinal bypass device for rectum surgery, which comprises a hollow sleeve, a film sleeve, a decompression air bag sleeved outside the hollow sleeve, and an inflation channel, wherein after being inflated, the decompression air bag protrudes in a corrugated or threaded mode in the axial direction of the hollow sleeve, the protruding part makes contact with the intestinal wall to provide friction force, and a decompression gap is formed between the sunken part and the intestinal wall; according to the invention, intestinal contents are discharged from the hollow sleeve and the film sleeve, so that excrement or intestinal juice is prevented from being in contact with an anastomotic stoma, the infection risk of the anastomotic stoma is reduced, and the healing rate of the anastomotic stoma is accelerated; the thin film sleeve is soft and deformable, so that discomfort such as anus falling expansion, pain and tenesmus of a patient can be effectively reduced, and the comfort of the patient is improved; the decompression air bag is expanded through the inflation channel, the hollow sleeve is positioned, meanwhile, blood supply of the intestinal wall is protected, and the reliable effect of replacing preventive fistulization is achieved.

The invention belongs to the technical field of dental pulp blood supply reconstruction, and relates to a multi-omics data fusion analysis method for EDTA (Ethylene Diamine Tetraacetic Acid) induced cell differentiation in dental pulp blood supply reconstruction. A space-time matched multi-level data basis is provided for analyzing a dynamic rule; then through standardization processing and difference analysis, screening out differential molecules which realize corresponding modes and are strongly related to phenotypes, focusing on core regulation and control candidate objects, and avoiding limitation of single omics; the method comprises the following steps: constructing a dynamic multi-layer regulation and control network comprising a transcription layer, a protein layer, a metabolism layer and interlayer connections thereof, finally identifying key nodes and modules through network topology analysis, tracking a time evolution rule in combination with dynamic trajectory analysis, and finally screening a core regulation and control module and predicting a cross-level key path. System analysis from multi-omics data to a hierarchical regulation and control mechanism and a dynamic rule is realized, and the limitation of single-dimension research is effectively broken through.

The application discloses a percutaneous lung puncture path planning method and device based on lung segment level blood vessel structure constraint, and the method comprises the following steps: performing isotropic resampling, lung lobe segmentation and bronchial tree extraction on CT image data to generate a three-dimensional lung dissection model; inputting the three-dimensional lung dissection model into a lung segment semantic segmentation module to output a lung segment boundary; reconstructing the topological connection relationship between lung segment level blood supply arteries and drainage veins from the lung segment boundary to obtain a structured lung segment level blood vessel atlas; constructing a dynamic puncture risk field voxel map according to the structured lung segment level blood vessel atlas; sampling a plurality of candidate needle entry points in a surface feasible needle entry region to generate an initial path set in the three-dimensional lung dissection model; and weighting the path length, cumulative risk value, puncture angle penalty and high-density lung tissue volume according to a multi-objective optimization function to output a final puncture path. The application significantly improves the safety boundary and clinical applicability of percutaneous lung puncture.