Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

243 results about "Blood supply" patented technology

Cerebral apoplexy onset risk assessment and reminding method and cerebral apoplexy onset risk assessment and reminding system

The invention relates to the technical field of intelligent medical systems, and discloses a cerebral apoplexy onset risk assessment and reminding method and system.The method comprises the steps that continuous medical structured detection data are collected, and the data comprise carotid artery blood flow parameters, brain oxygen saturation, heart rate variability and metabolic indexes; inputting a bidirectional LSTM, a differential convolutional network, a wavelet residual network and a multi-layer perceptron to extract nonlinear features; constructing a neural function coupling structure diagram of four nodes of cerebral blood supply, oxygen supply, autonomous regulation and metabolic steady state; calculating inter-node time sequence offset correlation and a stable factor to obtain a coupling anomaly coefficient; and driving the embedded network by using a graph structure and a node feature input mechanism, and outputting a risk state assessment result. According to the method, the neural function coupling structure diagram is constructed and the mechanism is introduced to drive the embedded network, so that high-precision identification of the multi-system collaborative abnormal state and dynamic evaluation of the stroke risk level are realized.
Owner:SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)

Dynamic blood flow simulation system based on brain oxygen entropy

The invention relates to the technical field of medical signal processing, in particular to a brain oxygen entropy-based dynamic blood flow simulation system which comprises a data acquisition module, a structure modeling module, a state monitoring module, a simulation calculation module and an anomaly prediction module. According to the method, through synchronous utilization of brain oxygen saturation and blood flow velocity signals, accurate capture of brain oxygen supply and blood flow dynamic dynamic correlation is achieved, sensitivity of abnormal fluctuation recognition is enhanced, individualization and accuracy of blood flow simulation are improved by combining a brain blood vessel geometric structure and blood vessel elasticity and compliance parameters, and multi-point dynamic coupling is utilized to achieve the purpose of improving the accuracy of blood flow simulation. According to the method, abnormal blood supply state recognition is enhanced, brain blood supply stability evaluation is optimized, the local blood flow micro-dynamic feature reduction degree is improved through dynamic updating of the inertia coefficient and the shear stress, the oxygen entropy fluctuation, the shear stress and the flow velocity gradient are combined, the nonlinear coupling relation is extracted, the abnormal event prediction accuracy is improved, and the brain blood supply stability is improved. And the early warning capability of abnormal cerebral blood supply is enhanced.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Sleeve for smoothly feeding blood

PendingCN120957780AMedical devicesIntravenous devicesAscending aortaBlood flow
The invention provides a cannula capable of effectively and smoothly conveying blood from the ascending aorta while reducing the diameter of the cannula. And the front end part of the cannula is retained in the ascending aorta and is used for smoothly conveying blood supplied by the in-vitro artificial membrane lung from the ascending aorta. The cannula comprises a forward blood backflow part (2) and a blood delivery tube (4), wherein the forward blood backflow part (2) is arranged at the front end of the blood delivery tube (4). A guide wire tube (5) which longitudinally extends from a base end part to a front end part is arranged at a near-center position of the axial length in the smooth blood feeding sleeve (1). The blood delivery tube (4) is a catheter arranged on the base end side and used for being connected with the in-vitro artificial membrane lung. The forward blood return unit (2) reverses blood from a reverse direction to a forward direction and guides the blood to the base end side, and is provided with a first blood return tube (6) provided on the base end side and a second blood return tube (7) provided on the tip side. The second blood return tube (7) has side holes (7a, 7b), and a part of an approximately hemispherical bag body (8) is adhered to the inner portion of the tip of the second blood return tube (7).
Owner:KOBE UNIV

Self-adaptive inflatable medical protection restraint system and monitoring control method

PendingCN121265345ARestraining devicesCompression injuryDynamic monitoring
The invention relates to the field of medical instruments, in particular to a self-adaptive inflatable medical protection restraint system and a monitoring control method. The system comprises a restraint strap body, a pneumatic control module, a biological feedback module and a system control module. An air bag array consisting of a plurality of independent air chambers is arranged in the restraint strap body; the pneumatic control module is used for inflating and deflating each air chamber; the biological feedback module is integrated on the belt body, comprises a pressure sensing unit and a blood supply sensing unit, and is used for monitoring and constraining interface pressure and limb blood supply state in real time; and the system control module receives the monitoring data, generates an instruction based on a preset safety parameter, and drives the pneumatic control module to perform self-adaptive pressure adjustment on the specified air chamber. According to the system, through dynamic monitoring and accurate adjustment, the problem that a traditional restraining device is prone to causing compression injury and blood supply disorder is effectively solved, and safety and comfort are remarkably improved.
Owner:PEKING UNIV INT HOSPITAL

Tissue engineering trachea and manufacturing method thereof

ActiveCN121177051ATubular organ implantsVascular channelBlood vessel
The invention relates to a tissue engineering trachea, which combines an additive manufacturing technology with a biological material, simulates the form and the function of a natural gas pipe, designs a cartilage-fiber alternating ring structure and a bionic fiber band structure, and designs a unique blood supply channel in a fiber section. The trachea fiber section is composed of hydrogel with a hierarchical porous structure, and a circumferential blood vessel channel and a radial blood vessel pore channel are designed in the hydrogel so as to promote ingrowth and growth of new blood vessels and optimize the blood supply reconstruction process. The tracheal cartilage section is made into a C-shaped cartilage ring with cartilage cells through a biological printing technology, and necessary mechanical support is provided. The fiber segment and the cartilage segment are effectively integrated through chemical bonds of functional groups to ensure stable connection of the two. Partitioned construction of fibers and cartilage is achieved through the biological 3D printing technology, the bionic tissue engineering trachea is formed in a modular construction-integrated assembly mode, it is verified that repairing and reconstruction of multiple types of tissue bionic tracheas can be achieved, and an innovative solution is provided for tracheal injuries.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Systems and methods for processing electronic images to assess end-organ demand

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.
Owner:HEARTFLOW INC

Novel multifunctional intestinal bypass device for rectum operation

The invention relates to the field of medical apparatus and instruments in rectum surgery, and particularly provides a novel multifunctional intestinal bypass device for rectum surgery, which comprises a hollow sleeve, a film sleeve, a decompression air bag sleeved outside the hollow sleeve, and an inflation channel, wherein after being inflated, the decompression air bag protrudes in a corrugated or threaded mode in the axial direction of the hollow sleeve, the protruding part makes contact with the intestinal wall to provide friction force, and a decompression gap is formed between the sunken part and the intestinal wall; according to the invention, intestinal contents are discharged from the hollow sleeve and the film sleeve, so that excrement or intestinal juice is prevented from being in contact with an anastomotic stoma, the infection risk of the anastomotic stoma is reduced, and the healing rate of the anastomotic stoma is accelerated; the thin film sleeve is soft and deformable, so that discomfort such as anus falling expansion, pain and tenesmus of a patient can be effectively reduced, and the comfort of the patient is improved; the decompression air bag is expanded through the inflation channel, the hollow sleeve is positioned, meanwhile, blood supply of the intestinal wall is protected, and the reliable effect of replacing preventive fistulization is achieved.
Owner:SICHUAN CANCER HOSPITAL

Multi-omics data fusion analysis method for EDTA (Ethylene Diamine Tetraacetic Acid) induced cell differentiation in dental pulp blood supply reconstruction

The invention belongs to the technical field of dental pulp blood supply reconstruction, and relates to a multi-omics data fusion analysis method for EDTA (Ethylene Diamine Tetraacetic Acid) induced cell differentiation in dental pulp blood supply reconstruction. A space-time matched multi-level data basis is provided for analyzing a dynamic rule; then through standardization processing and difference analysis, screening out differential molecules which realize corresponding modes and are strongly related to phenotypes, focusing on core regulation and control candidate objects, and avoiding limitation of single omics; the method comprises the following steps: constructing a dynamic multi-layer regulation and control network comprising a transcription layer, a protein layer, a metabolism layer and interlayer connections thereof, finally identifying key nodes and modules through network topology analysis, tracking a time evolution rule in combination with dynamic trajectory analysis, and finally screening a core regulation and control module and predicting a cross-level key path. System analysis from multi-omics data to a hierarchical regulation and control mechanism and a dynamic rule is realized, and the limitation of single-dimension research is effectively broken through.
Owner:ZUNYI MEDICAL UNIVERSITY

A percutaneous lung puncture path planning method based on pulmonary segment level blood vessel structure constraint

The application discloses a percutaneous lung puncture path planning method and device based on lung segment level blood vessel structure constraint, and the method comprises the following steps: performing isotropic resampling, lung lobe segmentation and bronchial tree extraction on CT image data to generate a three-dimensional lung dissection model; inputting the three-dimensional lung dissection model into a lung segment semantic segmentation module to output a lung segment boundary; reconstructing the topological connection relationship between lung segment level blood supply arteries and drainage veins from the lung segment boundary to obtain a structured lung segment level blood vessel atlas; constructing a dynamic puncture risk field voxel map according to the structured lung segment level blood vessel atlas; sampling a plurality of candidate needle entry points in a surface feasible needle entry region to generate an initial path set in the three-dimensional lung dissection model; and weighting the path length, cumulative risk value, puncture angle penalty and high-density lung tissue volume according to a multi-objective optimization function to output a final puncture path. The application significantly improves the safety boundary and clinical applicability of percutaneous lung puncture.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Efficient bleeding stopping suite for broken limbs

PendingCN121465672APressure infusionTourniquetsIntra arterialControl valves
The invention relates to a medical first-aid instrument. The efficient bleeding stopping suite for the broken limb comprises an anastomosis cylinder and connecting assemblies arranged at the two ends of the anastomosis cylinder and used for being combined with the broken end. The center of the anastomosis cylinder is provided with a funnel-shaped center cone which is gradually shrunk towards the telecentric end, and the telecentric end of the center cone and the anastomosis cylinder are coaxially provided with a center cylinder; the central cylinder is communicated with the central cone, and a control valve is arranged on the central cylinder; an anastomosis needle used for being inserted into a broken limb artery is further arranged at the distal end of the center cylinder. Targeted rapid hemostasis can be effectively achieved on the whole, stable temporary blood supply is efficiently constructed, and the replanting survival rate of the fractured limbs is remarkably improved.
Owner:THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV

Oral implant bone splitting operation method

PendingCN121359995ADental implantsBone implantBone flapBone Marrow Stromal Cell
The invention discloses an operation method for splitting an oral implant bone, which comprises the following steps of: preparing an ultrathin bone sheet of which the buccal side is less than 1mm, reserving physiological connection between periosteum and the bone sheet, and constructing a periosteum bone flap. The periosteum flap is of a natural barrier membrane structure, and integrates the function of a bone sheet rigid support and the semi-permeable membrane characteristic of the periosteum. The buccal ultrathin bone sheet is connected with the basal bone, is a rigid support structure, supports an osteogenesis space, and can provide bone marrow stroma cells to participate in bone defect repair. Physiological attachment of periosteum is not only a blood supply source of an inner side bone sheet, but also exerts the characteristics of a semi-permeable membrane, replaces an artificial barrier membrane to stop fiber tissue from growing in, and follows the PASS principle of the GBR technology, so that the operation risk is reduced, the use of the artificial barrier membrane is reduced, the adaptation disease of bone splitting is widened, the absorption of buccal side bones is reduced, and the bone splitting effect is improved. And the clinical effect of bone defect repair is improved.
Owner:JINHUA MUNICIPAL CENT HOSPITAL

A patch kit with patient information

The application relates to the field of patient information labels, and provides a dressing kit with patient information, which comprises a transparent dressing layer, a printing layer and a release layer, the dressing layer has a sticking surface and is used for sticking to the skin of a patient, the sticking surface comprises an identification area and a sticking area, and the sticking area is arranged around the identification area; the printing layer is attached in the identification area, and the surface of the printing layer facing the sticking surface forms an identification surface, the identification surface is used for displaying patient information; and the release layer is annular in shape and covers the sticking area. According to the utility model, the printing layer is covered by the dressing layer and is attached to the skin of a patient, the problem that the printing layer can only be fixed to a limb is solved, the situation that a critical patient is easily pressed to cause skin damage or poor blood supply is avoided, and the printing layer is not exposed to the outside and is not easily affected by friction and stains.
Owner:SHENZHEN PEOPLES HOSPITAL

Macromolecular blood circulation blocking prevention elastic bandage

ActiveCN223615020UBandagesWound skinElastic bandage
The utility model designs a high-molecular blood circulation blocking prevention elastic bandage, which comprises a high-molecular elastic bandage and is characterized in that a plurality of elastic sheets are arranged on the front surface of the high-molecular elastic bandage. And a plurality of elastic sheets are arranged on the back surface of the macromolecular elastic bandage. And the elastic sheet is square or circular. The elastic sheet is made of a foam material, and the foam material is polyurethane foam. The high-molecular elastic bandage has the advantages that after a bound wound swells, due to the fact that the high-molecular elastic bandage is covered with the foam materials, a buffer area exists between the bandage and the skin of the wound, and the interval areas between the foam materials can relieve compression on the skin and reduce the influence on blood supply.
Owner:SHANGHAI KAIRONG MEDICAL TECH CO LTD

Temperature monitoring system and method based on temperature measurement type kirschner wire

The invention belongs to the technical field of medical instruments, and relates to a temperature monitoring system and method based on a temperature measurement type kirschner wire. The multi-point temperature measuring optical cable is arranged in the length direction of the kirschner wire, so that the multi-point temperature measuring optical cable can obtain temperature data of the healthy side and the affected side of the limb while the kirschner wire plays the original functions of fixing the skeleton of the broken limb and the like, and inconvenience and possible influence on the limb caused by additional arrangement of a temperature measuring device are avoided. The detection receiving unit serves as an intermediate link and is connected with the multi-point temperature measurement optical cable and the data acquisition and analysis system. And the data acquisition and analysis system is used for receiving the temperature data transmitted by the detection receiving unit and carrying out temperature monitoring and early warning according to the temperature data. Medical staff are reminded to take corresponding measures in time, real-time and accurate monitoring of the blood supply state after the amputated limb replantation operation can be achieved, and the medical staff can recognize and process vascular crisis in time.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Diabetic foot patient path management method and system based on lower limb vasculopathy grading

The invention belongs to the technical field of diabetic foot clinical path management, and discloses a diabetic foot patient path management method and system based on lower limb vasculopathy grading. Mapping the ulcer position to the corresponding perfusion area and the artery segment to generate ulcer space characteristics; calculating a blood supply risk score of the perfusion area and generating a space risk map by combining the blood vessel image detection data and the microcirculation detection data; then collecting time sequence data including an ulcer index, an infection index, a blood supply index and a space risk map, and predicting the progress speed and the risk level of the future ulcer course; and finally, according to the blood supply risk score and the disease course prediction result, generating an individualized path management scheme through a joint triggering rule. According to the invention, precise and dynamic management of the diabetic foot ulcer is realized, the healing rate is improved, and the recurrence rate and the medical cost are reduced.
Owner:HE BEI SHENG ZHONG YI YUAN (FIRST AFFILIATED HOSPITAL OF HEBEI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE HEBEI CENTER FOR PREVENTION & CONTROL OF SCOLIOSIS IN CHILDREN & ADOLESCENTS)

Aortic dissection rupture closure device

ActiveCN122423919BAorta aorticFalse lumen
The application provides an aortic dissection rupture sealing device, which comprises a body having a hollow flow channel extending along the axial direction of the body, the hollow flow channel penetrating the rupture for conducting the true lumen of the aorta and the branch blood vessel, and the body being used for connecting a stent located in the branch blood vessel; and an anchoring part arranged on the body and surrounding the hollow flow channel, and anchored to the surrounding intima at the rupture, so as to prevent the fluid from conducting between the true lumen and the false lumen formed at the rupture. By using the above scheme, the rupture sealing effect can be improved, the continuous expansion of the false lumen caused by the incomplete rupture sealing and the residual liquid leakage can be avoided, and the blood supply stability of the branch blood vessel can be ensured, so that the blood supply demand of the internal organs, the spinal cord and the like supplied by the branch blood vessel can be met.
Owner:SHANGHAI SHAPE MEMORY ALLOY

A thyroid nodule ablation control system based on ultrasound contrast parameters

PendingCN122320673AIntraoperative bleedingTarget tissue
The application relates to the field of medical image assisted ablation technology, and provides a thyroid nodule ablation control system based on ultrasound contrast parameters. The system comprises an ultrasound data acquisition module, a contrast parameter analysis module, a blood supply identification module, an ablation strategy generation module, an ablation execution module, a feedback evaluation module, a closed-loop control module and an energy optimization module. By acquiring an ultrasound contrast image of target tissue, perfusion time, perfusion intensity and perfusion sequence parameters are extracted, blood supply arteries or blood supply areas are identified, and a phased ablation strategy is generated, the blood supply area is preferentially ablated, and then main ablation is carried out on the target tissue; at the same time, residual active areas are detected based on contrast feedback, and supplementary ablation is carried out through a closed-loop control mechanism; and ablation parameters are dynamically optimized in combination with a unit volume energy model. The system can improve ablation integrity, reduce the heat sink effect and the risk of intraoperative bleeding, reduce the recurrence rate, and improve energy utilization efficiency.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL OF JILIN UNIV

Aortic dissection rupture closure device

ActiveCN122423920BAorta aorticFalse lumen
The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.
Owner:SHANGHAI SHAPE MEMORY ALLOY

Device for dynamically monitoring blood supply disorder after flap transplantation based on MEMS capacitive sensor and use method

The invention discloses a skin flap transplantation post-operation blood supply disorder dynamic monitoring device based on an MEMS capacitive sensor and a using method, the device comprises a fitting layer and a sensor layer, the fitting layer is of a three-layer structure, and stable fitting and biocompatibility of the device and a skin flap area are achieved; the sensor layer comprises a signal monitoring module and a signal transmission module, the signal monitoring module forms an array by a plurality of capacitive sensing units, and skin flap tissue swelling is converted into a capacitance signal with position identification through the MEMS parallel plate capacitance principle; after being processed and converted, the capacitance signal is wirelessly transmitted to external equipment through low-power-consumption Bluetooth. And medical personnel judge the blood supply disorder and the occurrence area after the skin flap operation based on the capacitance signal change trend. The device disclosed by the invention integrates miniaturization and integration, can monitor in real time, reduces manpower consumption, provides data support for early intervention of blood supply disorder, and is suitable for post-operation clinical monitoring of skin flap transplantation.
Owner:YICHANG CENT PEOPLES HOSPITAL +1

Magnetic nano-drug carrier

The invention belongs to the technical field of drug carriers, and particularly relates to a magnetic nano-drug carrier which is prepared by the following steps: selecting traditional Chinese medicine raw materials and auxiliary raw materials, and selecting corresponding equipment for treating the raw materials; traditional Chinese medicine raw materials are pretreated, effective components are extracted through ultrasonic and reflux combination, and finally an extracting solution is purified and concentrated; preparing through a coprecipitation method; the flexible traditional Chinese medicine dressing is prepared by taking anti-inflammatory, analgesic, blood-activating and blood-stasis-removing active ingredients of 19 traditional Chinese medicines as cores and combining with the local magnetic response enrichment characteristic of the magnetic nano-carrier, the flexible traditional Chinese medicine dressing is attached to a pressurized silica gel pad of a PCI postoperative wrist strap for use, local directional enrichment of the active ingredients of the traditional Chinese medicines in a wound is promoted through the magnetic carrier, and the wound healing effect is improved. The pressurizing silica gel pad has the synergistic effects of resisting inflammation, easing pain, improving microcirculation and dredging collaterals and restoring the pulse, solves clinical pain points such as inflammation edema, obvious pain and unsmooth local blood supply of a wrist puncture wound after the PCI operation, and meets the requirements of flexibility, ventilation and fitting of the pressurizing silica gel pad at the same time.
Owner:GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI

Handheld rapid three-dimensional fundus blood supply imaging system and method

PendingCN121606248AOthalmoscopesStimulate raman scatteringData acquisition
The invention discloses a handheld rapid three-dimensional fundus blood supply imaging system and method.The system comprises an upper computer, a laser excitation module, a probe, a data collection module and a space positioning module, the laser excitation module, the probe, the data collection module and the space positioning module are connected with the upper computer, and the laser excitation module conducts wavelength conversion on input pump laser through the stimulated Raman scattering principle to generate excitation light; the exciting light is then transmitted to the probe for high-speed scanning, the probe receives real-time pose feedback of the space positioning module at the same time so as to eliminate the influence of operation jitter, the data acquisition module pre-processes a photoacoustic signal acquired by the probe and then transmits the photoacoustic signal to the upper computer, and a distribution diagram is generated through an image reconstruction algorithm and analyzed. According to the invention, four clinical troubles of poor molecular specificity, depth-resolution imbalance, low clinical adaptability and deficiency of quantitative standards in the existing imaging technology are fundamentally solved, and a universal tool is provided for early screening of eye ground ischemic diseases.
Owner:BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIVERSITY +1

Balloon catheter

This invention provides a balloon catheter comprising a catheter, a balloon, and a limiting element. The balloon is positioned distal to or near the distal end of the catheter. The limiting element is located on the outer side of the balloon, and at least a portion of the limiting element is capable of radial movement or radial deformation to drive the balloon to move radially inward. The balloon catheter provided by this invention allows physicians to adjust the limiting element to contact the balloon and deform it, ensuring that a portion of the balloon remains firmly attached to the blood vessel. This reduces the risk of balloon displacement, prevents the balloon from losing its function of dilating blood vessels or blocking aneurysms due to displacement, and improves the stability and reliability of balloon implantation. Simultaneously, it allows another portion of the balloon to no longer be tightly attached to the blood vessel wall, creating a gap to form a fluid channel, allowing a small amount of blood to flow between the two ends of the balloon, ensuring blood supply to distal organs, reducing surgical complications, reducing pressure on patients and physicians, and increasing the success rate of surgery.
Owner:LIFETECH SCI (SHENZHEN) CO LTD

Sequential slow-release hydrogen sulfide nerve repair conduit and preparation method thereof

The invention provides a sequential slow-release hydrogen sulfide nerve repair conduit and a preparation method thereof, and belongs to the technical field of biological materials. The sequential slow-release hydrogen sulfide nerve repair conduit comprises degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel and a pH response hydrogen sulfide donor, wherein the degradable polymer conduit is filled with the degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, and the pH response hydrogen sulfide donor is loaded on the hydrogel. In the application, the pH response donor can respond to an acidic microenvironment of degradation of polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, release hydrogen sulfide and relieve the acidic environment generated by degradation of the hydrogel at the same time, and form a dual supply mechanism with cysteine (endogenous hydrogen sulfide precursor) obtained by degradation of the hydrogel; nerve regeneration and angiogenesis are synergistically promoted, and oxidative stress is regulated; and the hydrogel is accelerated to degrade during excessive oxidative stress, so that hydrogen sulfide is released as required, and the core problems of insufficient blood supply, unbalanced acidic microenvironment and slow nerve regeneration are synchronously solved.
Owner:湖北江夏实验室 +1

An intelligent probe patch for micro free skin flap blood supply monitoring

This invention relates to the field of medical device technology, and more particularly to an intelligent probe patch for monitoring blood circulation in microscopic free flaps, comprising: a disposable probe patch configured to be attached to the surface or edge of the free flap; a biocompatible adhesive layer is provided on the bottom surface of the flexible base of the disposable probe patch, and an auxiliary structure is provided on the top of the flexible base to resist postoperative tissue activity or secretions; the disposable probe patch integrates an optical sensing unit and a temperature sensing unit for collecting local blood oxygen saturation, pulse rate, and surface temperature of the flap, respectively; a repeater, establishing non-contact near-field coupling with the disposable probe patch, the repeater being configured to provide working power to the disposable probe patch through near-field coupling, enabling it to operate without a built-in battery; and synchronously receiving physiological parameter data reflecting the local microcirculation status of the flap collected by the disposable probe patch; and a terminal device, wirelessly connected to the repeater, receiving and processing the physiological parameter data.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

A traditional Chinese medicine composition for treating glaucoma and a preparation method thereof

PendingCN122321079ALicorice rootsOptic nerve atrophy
This invention relates to the field of traditional Chinese medicine (TCM) technology. The invention provides a TCM composition for treating glaucoma and its preparation method, comprising the following components in parts by weight: 18-28 parts of Cassia seed, 12-18 parts of Lycium fruit, 12-18 parts of Eriocaulon buergerianum, 10-15 parts of vinegar-processed Cyperus rotundus, 10-15 parts of mulberry leaf, 10-15 parts of Ligusticum chuanxiong, 8-12 parts of Polyporus umbellatus, 5-8 parts of Pueraria lobata, 5-8 parts of Akebia quinata, 3-5 parts of Curcuma longa, 3-5 parts of Indigo naturalis, and 2-4 parts of prepared licorice root. The TCM composition of this invention has a strong effect in lowering intraocular pressure, improving retinal blood supply, and preventing optic nerve atrophy caused by glaucoma; simultaneously, the processing method maximizes the retention of the active pharmaceutical ingredients. Furthermore, the technical solution of this invention achieves a dual improvement in efficacy and safety, and also reduces the recurrence rate and side effects.
Owner:孙礼华

Coronary heart disease echocardiogram pathological feature extraction method and system

The invention provides a coronary heart disease echocardiogram pathological feature extraction method and system. Static structure features and myocardial function features of the heart of a target coronary heart disease patient are determined through an ultrasonic video stream of the heart of the target coronary heart disease patient; determining a region mapping matrix of a relationship between a coronary artery blood supply region of the target coronary heart disease patient and a myocardial injury state according to the static structural characteristics and the myocardial functional characteristics, and determining boundary sharpening development of a pathological region in the heart of the target coronary heart disease patient according to the region mapping matrix; acquiring a myocardial movement track of the target coronary heart disease patient, and determining a longitudinal strain gradient of a basal segment and a cardiac apex segment of the heart of the target coronary heart disease patient according to the myocardial movement track; and based on the boundary sharpening development and the longitudinal strain gradient of the pathological area and in combination with the clinical pathological data of the target coronary heart disease patient, generating the cardiac physical characteristics of the target coronary heart disease patient. According to the scheme, the static structure and the dynamic function of the heart can be effectively associated and fused to extract the coronary heart disease echocardiogram features.
Owner:SUZHOU MUNICIPAL HOSPITAL

Blood oxygenation treatment methods and devices

ActiveUS12484903B2StentsHeart stimulatorsPulmonary vasculaturePharmacy medicine
Methods and devices for increasing oxygenation levels in the blood supply and thereby treating the condition of hypoxemia. Multiple approaches such as pressure reduction in the pulmonary circulatory system, reducing triggering mechanisms in the main pulmonary artery and restricting flow in the pulmonary circulatory system are disclosed. Interventions associated with those approaches can including shunting, restrictors, compliance devices, pharmacologic substances, etc.
Owner:EDWARDS LIFESCIENCES CORP

Method for screening heart failure oxidized lipid after AMI based on solid-phase extraction, LC-MS / MS and AI

PendingCN121830993AComponent separationLipid screeningHematological test
The invention discloses a post-AMI heart failure oxidized lipid screening method based on solid phase extraction, LC-MS / MS and AI. The method comprises the steps of blood sample pretreatment, solid phase extraction and purification, LC-MS / MS detection and AI model screening. According to the method, high-sensitivity qualitative and quantitative detection of oxidized lipid is realized through optimized LC-MS / MS parameters, and key oxidized lipid molecules and risk levels of heart failure after AMI emergency treatment blood supply reconstruction can be quickly and accurately screened in combination with a trained random forest AI model; the kit solves the problems that in the prior art, trace oxidized lipid detection sensitivity is low, specificity is poor, and heart failure risk screening lags, has the advantages of being high in detection efficiency, good in accuracy and high in practicability, can provide a scientific basis for early warning and intervention of clinical heart failure after AMI, and has high clinical application value.
Owner:NINGBO MEDICAL CENT LIHUILI HOSPITACL +1

Pelvic tumor resection incision construction system and pelvic tumor en bloc resection system

The application discloses a pelvic tumor resection surgical incision construction system and a pelvic tumor whole piece resection system. When a tumor does not affect a Ⅳ area, a projection point of a iliac crest on a body surface is taken as a starting point, and a projection point on the body surface is extended in a pubis direction of the iliac bone. According to different extension points, a single smooth virtual incision path one is constructed by bending downward in a thigh direction. When the tumor affects the Ⅳ area and other areas, the virtual incision path is two independent and non-intersecting first incision paths and second incision paths. The first incision path is extended from a body surface projection point of a longitudinal axis of a vertebral body to a sacrum direction, and is an incision path that is inclined to a tumor side in a sacrum area. The second incision path is a line connecting a body back projection point of the iliac crest to a body front projection point, and is combined with a corresponding smooth virtual incision path one to construct a complete smooth virtual incision path two. Through the above-mentioned method, incision intersection can be effectively avoided, and the incision path is beneficial to blood supply, and the healing effect is ensured.
Owner:PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)

Mulberry leaf tea with high active ingredient retention rate and preparation method thereof

The invention relates to the technical field of tea leaf processing, in particular to mulberry leaf tea with a high activity component retention rate and a preparation method of the mulberry leaf tea. Comprising the following steps: carrying out ultrasonic cleaning on fresh mulberry leaves, carrying out segmented temperature-controlled fixation, carrying out vacuum low-temperature rolling, adding Pankg ancient tree black tea, pseudo-ginseng, radix puerariae and waxy corn, carrying out stepped variable-temperature fermentation, carrying out freeze drying, and carrying out nitrogen-filled packaging. The mulberry leaf tea prepared by the preparation method disclosed by the invention is yellow-green and transparent in tea soup, free of grass smell, fresh and slightly sweet in taste and fresh in fragrance of waxy corn, and has certain effects of delaying aging and brown spots, reducing blood fat, blood pressure and blood sugar and improving myocardial blood supply and cerebral blood supply functions in cooperation with the Panku ancient tree black tea, the pseudo-ginseng and the radix puerariae, has an antimicrobial effect, can clear liver and improve eyesight, and has a good health care effect. Clearing lung and moistening dryness; the leaf integrity of the prepared mulberry leaf tea is larger than 90%, the reconstitution property is good, and it is detected that the total flavone content is larger than or equal to 86%, the 1-deoxynojirimycin content is larger than or equal to 91%, and the gamma-aminobutyric acid content is larger than or equal to 88%.
Owner:GUIZHOU ANGYANG ORIGINAL ECOLOGICAL DEVELOPMENT CO LTD