The invention relates to the technical field of rhinitis
medicine preparation, in particular to
zirconium-doped
cerium oxide nano-
enzyme for preparing allergic rhinitis drops and a preparation method of the
zirconium-doped
cerium oxide nano-
enzyme. The preparation method comprises the following steps: step 1, weighing a
cerium acetylacetonate (III)
hydrate and a
zirconium acetylacetonate (IV)
hydrate, adding into
oleylamine, magnetically stirring and uniformly mixing, and carrying out ultrasonic treatment on the mixture; step 2, putting the
mixed solution in the step 1 into a
drying oven, heating, preserving heat, and aging to obtain a dark brown
colloidal solution; step 3, naturally cooling the
colloidal solution to
room temperature, adding
acetone, centrifuging, discarding supernate, and repeating centrifugal washing for several times; and 4, carrying out
vacuum drying on the precipitate obtained in the step 3, and fully
grinding to obtain the zirconium-doped
cerium oxide nano-
enzyme. The prepared zirconium-doped
cerium oxide nano-enzyme is applied to preparation of allergic rhinitis drops. The zirconium-doped
cerium oxide nano enzyme reduces the inflammatory
factor level of the AR mouse and inhibits
degranulation of nasal mucosa MCs, so that the
pathological state and
allergic symptoms of the AR mouse are improved.